ANKS4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.97087483
2L-phenylalanine catabolic process (GO:0006559)6.97087483
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69440231
4L-phenylalanine metabolic process (GO:0006558)6.69440231
5aromatic amino acid family catabolic process (GO:0009074)6.51944170
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22670839
7tryptophan catabolic process (GO:0006569)6.11373501
8indole-containing compound catabolic process (GO:0042436)6.11373501
9indolalkylamine catabolic process (GO:0046218)6.11373501
10kynurenine metabolic process (GO:0070189)5.81692741
11tryptophan metabolic process (GO:0006568)5.74757633
12urea cycle (GO:0000050)5.48562844
13urea metabolic process (GO:0019627)5.48562844
14bile acid biosynthetic process (GO:0006699)5.46236773
15high-density lipoprotein particle remodeling (GO:0034375)5.36953097
16glyoxylate metabolic process (GO:0046487)5.33635122
17sulfur amino acid catabolic process (GO:0000098)5.23342143
18cysteine metabolic process (GO:0006534)5.14101074
19alpha-linolenic acid metabolic process (GO:0036109)5.04837189
20nitrogen cycle metabolic process (GO:0071941)5.03109081
21regulation of cholesterol esterification (GO:0010872)4.96299923
22bile acid metabolic process (GO:0008206)4.96196050
23homocysteine metabolic process (GO:0050667)4.94058115
24phospholipid efflux (GO:0033700)4.90571089
25regulation of triglyceride catabolic process (GO:0010896)4.83725705
26negative regulation of fibrinolysis (GO:0051918)4.82046184
27bile acid and bile salt transport (GO:0015721)4.81951419
28reverse cholesterol transport (GO:0043691)4.79837350
29protein carboxylation (GO:0018214)4.77332127
30peptidyl-glutamic acid carboxylation (GO:0017187)4.77332127
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76191640
32behavioral response to nicotine (GO:0035095)4.74751566
33aromatic amino acid family metabolic process (GO:0009072)4.74449442
34cellular ketone body metabolic process (GO:0046950)4.72718161
35complement activation, alternative pathway (GO:0006957)4.72390773
36serine family amino acid catabolic process (GO:0009071)4.72304385
37regulation of fibrinolysis (GO:0051917)4.72192343
38drug catabolic process (GO:0042737)4.71512785
39regulation of protein activation cascade (GO:2000257)4.70342870
40plasma lipoprotein particle remodeling (GO:0034369)4.67400180
41protein-lipid complex remodeling (GO:0034368)4.67400180
42macromolecular complex remodeling (GO:0034367)4.67400180
43epoxygenase P450 pathway (GO:0019373)4.56686554
44triglyceride homeostasis (GO:0070328)4.53829935
45acylglycerol homeostasis (GO:0055090)4.53829935
46negative regulation of cholesterol transport (GO:0032375)4.53497116
47negative regulation of sterol transport (GO:0032372)4.53497116
48lysine metabolic process (GO:0006553)4.52877737
49lysine catabolic process (GO:0006554)4.52877737
50cellular glucuronidation (GO:0052695)4.51299400
51intestinal cholesterol absorption (GO:0030299)4.50010913
52L-fucose catabolic process (GO:0042355)4.46856920
53fucose catabolic process (GO:0019317)4.46856920
54L-fucose metabolic process (GO:0042354)4.46856920
55amino-acid betaine metabolic process (GO:0006577)4.46404746
56indolalkylamine metabolic process (GO:0006586)4.40009029
57regulation of complement activation (GO:0030449)4.38256054
58tyrosine metabolic process (GO:0006570)4.36546266
59cholesterol efflux (GO:0033344)4.35240209
60alpha-amino acid catabolic process (GO:1901606)4.33043637
61cellular biogenic amine catabolic process (GO:0042402)4.24808817
62amine catabolic process (GO:0009310)4.24808817
63regulation of bile acid biosynthetic process (GO:0070857)4.24334546
64plasma lipoprotein particle assembly (GO:0034377)4.16458576
65coenzyme catabolic process (GO:0009109)4.08321897
66ketone body metabolic process (GO:1902224)4.07715623
67sulfation (GO:0051923)4.06904279
68plasma lipoprotein particle clearance (GO:0034381)4.04758840
69benzene-containing compound metabolic process (GO:0042537)4.04688098
70uronic acid metabolic process (GO:0006063)4.04534853
71glucuronate metabolic process (GO:0019585)4.04534853
72cellular amino acid catabolic process (GO:0009063)4.02086273
73flavonoid metabolic process (GO:0009812)4.00508689
74imidazole-containing compound metabolic process (GO:0052803)3.97854585
75positive regulation of triglyceride lipase activity (GO:0061365)3.96582275
76positive regulation of lipoprotein lipase activity (GO:0051006)3.96582275
77regulation of guanylate cyclase activity (GO:0031282)3.95043096
78very-low-density lipoprotein particle assembly (GO:0034379)3.92897023
79glutamate metabolic process (GO:0006536)3.91133040
80drug transmembrane transport (GO:0006855)3.91004699
81low-density lipoprotein particle remodeling (GO:0034374)3.86808218
82exogenous drug catabolic process (GO:0042738)3.86166929
83cholesterol homeostasis (GO:0042632)3.84146400
84cellular modified amino acid catabolic process (GO:0042219)3.83337480
85serine family amino acid metabolic process (GO:0009069)3.83239555
86glycine metabolic process (GO:0006544)3.82954966
87phospholipid homeostasis (GO:0055091)3.81178198
88sterol homeostasis (GO:0055092)3.80260149
893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.78857927
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.78857927
91arginine metabolic process (GO:0006525)3.77934214
92intestinal absorption (GO:0050892)3.76966917
93water-soluble vitamin biosynthetic process (GO:0042364)3.76355384
94lipoprotein metabolic process (GO:0042157)3.73419535
95protein-lipid complex assembly (GO:0065005)3.73205356
96ethanol oxidation (GO:0006069)3.72623695
97angiotensin maturation (GO:0002003)3.70536685
98regulation of cholesterol homeostasis (GO:2000188)3.67823884
99serine family amino acid biosynthetic process (GO:0009070)3.65595067
100plasma lipoprotein particle organization (GO:0071827)3.63493434
101positive regulation of lipid catabolic process (GO:0050996)3.61761104
102short-chain fatty acid metabolic process (GO:0046459)3.61386404
103negative regulation of lipase activity (GO:0060192)3.58438927
104aldehyde catabolic process (GO:0046185)3.57710986
105urate metabolic process (GO:0046415)3.57667367
106drug metabolic process (GO:0017144)3.57481585
107dicarboxylic acid biosynthetic process (GO:0043650)3.57237882
108organic acid catabolic process (GO:0016054)3.56031949
109carboxylic acid catabolic process (GO:0046395)3.56031949
110NAD biosynthetic process (GO:0009435)3.53788719
111regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51400788
112alkaloid metabolic process (GO:0009820)3.50844952
113fibrinolysis (GO:0042730)3.49978157
114sulfate transmembrane transport (GO:1902358)3.49255483
115vitamin biosynthetic process (GO:0009110)3.44037132
116transepithelial transport (GO:0070633)3.42225873
117positive regulation of guanylate cyclase activity (GO:0031284)3.35519257
118positive regulation of fatty acid transport (GO:2000193)3.26236121
119oxidative demethylation (GO:0070989)3.21726462
120fat-soluble vitamin biosynthetic process (GO:0042362)3.11718880
121positive regulation of icosanoid secretion (GO:0032305)3.03756464
122positive regulation of fatty acid beta-oxidation (GO:0032000)3.03360970
123detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98337515
124nephron epithelium morphogenesis (GO:0072088)2.96540108
125nephron tubule morphogenesis (GO:0072078)2.96540108
126indole-containing compound metabolic process (GO:0042430)2.92007676
127primary amino compound metabolic process (GO:1901160)2.90499251
128sulfate transport (GO:0008272)2.89896873
129positive regulation of fatty acid oxidation (GO:0046321)2.88782220
130phenylpropanoid metabolic process (GO:0009698)2.88775855
131heme transport (GO:0015886)2.86599622
132fucosylation (GO:0036065)2.85735594
133kidney morphogenesis (GO:0060993)2.85207309
134glycerol metabolic process (GO:0006071)2.84110054
135detection of light stimulus involved in visual perception (GO:0050908)2.75874887
136detection of light stimulus involved in sensory perception (GO:0050962)2.75874887
137omega-hydroxylase P450 pathway (GO:0097267)2.73207298
138quinone biosynthetic process (GO:1901663)2.72945537
139L-ascorbic acid metabolic process (GO:0019852)2.72264511
140regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.72194050
141endocrine process (GO:0050886)2.72194050
142regulation of systemic arterial blood pressure by hormone (GO:0001990)2.72194050
143lipoprotein transport (GO:0042953)2.70522161
144nucleobase catabolic process (GO:0046113)2.65817249
145digestion (GO:0007586)2.64968717
146regulation of cGMP biosynthetic process (GO:0030826)2.54886345
147phosphatidylinositol acyl-chain remodeling (GO:0036149)2.53502965
148vitamin transmembrane transport (GO:0035461)2.53338360
149endocrine pancreas development (GO:0031018)2.53049651
150serotonin metabolic process (GO:0042428)2.52818321
151proline transport (GO:0015824)2.52646947
152S-adenosylmethionine metabolic process (GO:0046500)2.49368218
153auditory receptor cell differentiation (GO:0042491)2.48388524
154alditol metabolic process (GO:0019400)2.48280871
155regulation of systemic arterial blood pressure (GO:0003073)2.47905384
156sulfur compound transport (GO:0072348)2.47221208
157diacylglycerol metabolic process (GO:0046339)2.45087215
158cytidine deamination (GO:0009972)2.44913225
159cytidine metabolic process (GO:0046087)2.44913225
160cytidine catabolic process (GO:0006216)2.44913225
161vitamin transport (GO:0051180)2.44611493
162peptide hormone processing (GO:0016486)2.43857139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.80485941
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.81527794
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.75606128
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.17530546
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.88992787
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.65582048
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.90554267
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81548133
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67726842
10ZNF274_21170338_ChIP-Seq_K562_Hela3.26502172
11VDR_22108803_ChIP-Seq_LS180_Human3.06144313
12EZH2_22144423_ChIP-Seq_EOC_Human2.50339437
13GBX2_23144817_ChIP-Seq_PC3_Human2.33205299
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21698061
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16255350
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03520210
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.00031136
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7543971
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90753464
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88255348
21IGF1R_20145208_ChIP-Seq_DFB_Human1.86976399
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78104862
23P300_19829295_ChIP-Seq_ESCs_Human1.76509904
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74642086
25ER_23166858_ChIP-Seq_MCF-7_Human1.71193171
26* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69531841
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.65486581
28FUS_26573619_Chip-Seq_HEK293_Human1.64728846
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63554733
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63281005
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.59237334
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56664858
33HTT_18923047_ChIP-ChIP_STHdh_Human1.56353373
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55274085
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54610005
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53332305
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.52596861
38IRF1_19129219_ChIP-ChIP_H3396_Human1.51707504
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49289612
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47312125
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46652893
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44208967
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.44208967
44EWS_26573619_Chip-Seq_HEK293_Human1.42795728
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41335961
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40113063
47TCF4_22108803_ChIP-Seq_LS180_Human1.36358785
48STAT3_23295773_ChIP-Seq_U87_Human1.35967532
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35848083
50NANOG_19829295_ChIP-Seq_ESCs_Human1.35591917
51SOX2_19829295_ChIP-Seq_ESCs_Human1.35591917
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34237696
53GATA4_25053715_ChIP-Seq_YYC3_Human1.33892454
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.33551744
55GATA1_22025678_ChIP-Seq_K562_Human1.31569060
56CBP_20019798_ChIP-Seq_JUKART_Human1.30836436
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30836436
58AR_25329375_ChIP-Seq_VCAP_Human1.29720407
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29483315
60TP53_22573176_ChIP-Seq_HFKS_Human1.29203632
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28376981
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26847598
63REST_21632747_ChIP-Seq_MESCs_Mouse1.26024848
64TCF4_23295773_ChIP-Seq_U87_Human1.25612416
65NCOR_22424771_ChIP-Seq_293T_Human1.24747936
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24119418
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23403179
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.19605260
69SMAD4_21799915_ChIP-Seq_A2780_Human1.18313957
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16974626
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.16966880
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16744597
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16371538
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.15725372
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14074219
76KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12828772
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12152943
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11757058
79CLOCK_20551151_ChIP-Seq_293T_Human1.10372727
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.09815844
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08274214
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.07905975
83RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07561223
84MYC_19829295_ChIP-Seq_ESCs_Human1.07236157
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.06608809
86HOXB7_26014856_ChIP-Seq_BT474_Human1.05501617
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05351174
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05125594
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04226361
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02739378
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02633747
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02562777
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02382150
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02321158
95NANOG_20526341_ChIP-Seq_ESCs_Human1.02316288
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01697112
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01342702
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00946392
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00421070
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00421070
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.99893398
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97642191
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93894080
104AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87952635
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85246198
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83399620
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80052195
108SOX2_20726797_ChIP-Seq_SW620_Human0.79829319
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77108965
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76671734
111* GATA6_25053715_ChIP-Seq_YYC3_Human0.76461270
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75851264
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.75822470
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.75196606
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75124589
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73070287
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72597505
118* STAT1_17558387_ChIP-Seq_HELA_Human0.72436605
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72149370
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72149370
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72086585
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.71358503
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70745514
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70333104
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.69211277
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.68448637
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68081614
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.67078675
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.66875970
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.65701737
131CDX2_22108803_ChIP-Seq_LS180_Human0.65369684
132AR_20517297_ChIP-Seq_VCAP_Human0.64524945
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.64034937
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.63489224
135CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63239643
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63225252
137BCAT_22108803_ChIP-Seq_LS180_Human0.62954987
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.62713204
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62592212
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.62585176
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62527215
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.62152380
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.61391589
144EGR1_19032775_ChIP-ChIP_M12_Human0.61150172
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60732411
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.57917574
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.57370155
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.56939692
149CBP_21632823_ChIP-Seq_H3396_Human0.56771055
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.55695661
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.55193734
152GATA2_19941826_ChIP-Seq_K562_Human0.55173304
153MYC_19915707_ChIP-ChIP_AK7_Human0.55076435
154RARB_24833708_ChIP-Seq_LIVER_Mouse0.54515089
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54426810
156CEBPB_22108803_ChIP-Seq_LS180_Human0.53807447
157CRX_20693478_ChIP-Seq_RETINA_Mouse0.53740574
158ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.51292706
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.50058760
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.47814351
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.47528361
162RARG_19884340_ChIP-ChIP_MEFs_Mouse0.45524001
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.45416024
164ERG_20517297_ChIP-Seq_VCAP_Human0.45346890
165ESRRB_18555785_Chip-Seq_ESCs_Mouse0.45032788
166TAF15_26573619_Chip-Seq_HEK293_Human0.44975794
167GATA2_21666600_ChIP-Seq_HMVEC_Human0.44452515
168PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44437549
169P53_21459846_ChIP-Seq_SAOS-2_Human0.44206165
170TAF2_19829295_ChIP-Seq_ESCs_Human0.43996005
171SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.43559577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.05181468
2MP0005360_urolithiasis8.03747068
3MP0005085_abnormal_gallbladder_physiolo6.35820242
4MP0005365_abnormal_bile_salt6.00774713
5MP0008875_abnormal_xenobiotic_pharmacok5.04592208
6MP0003252_abnormal_bile_duct4.21571153
7MP0003806_abnormal_nucleotide_metabolis3.80658039
8MP0010329_abnormal_lipoprotein_level3.43808036
9MP0001666_abnormal_nutrient_absorption3.21652961
10MP0009840_abnormal_foam_cell3.10435326
11MP0004147_increased_porphyrin_level3.00953241
12MP0003195_calcinosis2.78993608
13MP0005332_abnormal_amino_acid2.72293976
14MP0005083_abnormal_biliary_tract2.53315847
15MP0004019_abnormal_vitamin_homeostasis2.49323499
16MP0003191_abnormal_cellular_cholesterol2.16988629
17MP0002138_abnormal_hepatobiliary_system2.13722323
18MP0003868_abnormal_feces_composition2.06882989
19MP0000609_abnormal_liver_physiology2.02372398
20MP0002118_abnormal_lipid_homeostasis1.99481250
21MP0005551_abnormal_eye_electrophysiolog1.98836536
22MP0003183_abnormal_peptide_metabolism1.91640766
23MP0009697_abnormal_copulation1.79633625
24MP0001501_abnormal_sleep_pattern1.74580466
25MP0005319_abnormal_enzyme/_coenzyme1.69374871
26MP0001485_abnormal_pinna_reflex1.64209677
27MP0001764_abnormal_homeostasis1.62340291
28MP0009643_abnormal_urine_homeostasis1.45784662
29MP0001664_abnormal_digestion1.45240940
30MP0005645_abnormal_hypothalamus_physiol1.44828154
31MP0005451_abnormal_body_composition1.44719655
32MP0002938_white_spotting1.42926467
33MP0002102_abnormal_ear_morphology1.42434568
34MP0005646_abnormal_pituitary_gland1.41245055
35MP0005584_abnormal_enzyme/coenzyme_acti1.40686612
36MP0002638_abnormal_pupillary_reflex1.39822101
37MP0009379_abnormal_foot_pigmentation1.36873424
38MP0004885_abnormal_endolymph1.34344704
39MP0001986_abnormal_taste_sensitivity1.34233634
40MP0006292_abnormal_olfactory_placode1.30984743
41MP0003122_maternal_imprinting1.29209877
42MP0008877_abnormal_DNA_methylation1.21561414
43MP0004142_abnormal_muscle_tone1.21160301
44MP0005084_abnormal_gallbladder_morpholo1.16520318
45MP0003879_abnormal_hair_cell1.16134804
46MP0009745_abnormal_behavioral_response1.15966049
47MP0002876_abnormal_thyroid_physiology1.14169926
48MP0002837_dystrophic_cardiac_calcinosis1.13639832
49MP0002272_abnormal_nervous_system1.12935575
50MP0003186_abnormal_redox_activity1.12619998
51MP0005636_abnormal_mineral_homeostasis1.12412932
52MP0002254_reproductive_system_inflammat1.07891163
53MP0003136_yellow_coat_color1.07793838
54MP0009764_decreased_sensitivity_to1.04144960
55MP0005647_abnormal_sex_gland1.03697196
56MP0006072_abnormal_retinal_apoptosis1.02491448
57MP0000598_abnormal_liver_morphology1.02129219
58MP0001968_abnormal_touch/_nociception1.01053129
59MP0000631_abnormal_neuroendocrine_gland1.00595759
60MP0003011_delayed_dark_adaptation0.99491786
61MP0004264_abnormal_extraembryonic_tissu0.99455638
62MP0002733_abnormal_thermal_nociception0.98690191
63MP0004742_abnormal_vestibular_system0.98532611
64MP0004043_abnormal_pH_regulation0.93668734
65MP0002909_abnormal_adrenal_gland0.92384079
66MP0005253_abnormal_eye_physiology0.91842812
67MP0004270_analgesia0.91839090
68MP0002064_seizures0.91345686
69MP0003656_abnormal_erythrocyte_physiolo0.91343782
70MP0002557_abnormal_social/conspecific_i0.90388266
71MP0000427_abnormal_hair_cycle0.89803893
72MP0009642_abnormal_blood_homeostasis0.89150151
73MP0005174_abnormal_tail_pigmentation0.88529933
74MP0004133_heterotaxia0.88436674
75MP0001529_abnormal_vocalization0.86994247
76MP0003283_abnormal_digestive_organ0.86571511
77MP0006276_abnormal_autonomic_nervous0.84963230
78MP0002078_abnormal_glucose_homeostasis0.84938519
79MP0005408_hypopigmentation0.84223232
80MP0005220_abnormal_exocrine_pancreas0.84023623
81MP0008469_abnormal_protein_level0.83815249
82MP0009763_increased_sensitivity_to0.83441486
83MP0009046_muscle_twitch0.82868287
84MP0002277_abnormal_respiratory_mucosa0.82801541
85MP0001486_abnormal_startle_reflex0.81340018
86MP0001970_abnormal_pain_threshold0.81167320
87MP0004924_abnormal_behavior0.78889835
88MP0005386_behavior/neurological_phenoty0.78889835
89MP0002734_abnormal_mechanical_nocicepti0.77375994
90MP0005389_reproductive_system_phenotype0.75219207
91MP0003866_abnormal_defecation0.74166157
92MP0005379_endocrine/exocrine_gland_phen0.74072073
93MP0003646_muscle_fatigue0.73444163
94MP0010386_abnormal_urinary_bladder0.73036906
95MP0002736_abnormal_nociception_after0.72740647
96MP0000604_amyloidosis0.72264118
97MP0001905_abnormal_dopamine_level0.72206790
98MP0005410_abnormal_fertilization0.71547822
99MP0005448_abnormal_energy_balance0.71361991
100MP0002572_abnormal_emotion/affect_behav0.71107536
101MP0001188_hyperpigmentation0.70775621
102MP0001756_abnormal_urination0.70603485
103MP0005376_homeostasis/metabolism_phenot0.70443879
104MP0002160_abnormal_reproductive_system0.70151335
105MP0000569_abnormal_digit_pigmentation0.70049403
106MP0009765_abnormal_xenobiotic_induced0.69546791
107MP0004782_abnormal_surfactant_physiolog0.68751197
108MP0005334_abnormal_fat_pad0.68208413
109MP0004145_abnormal_muscle_electrophysio0.67897015
110MP0000026_abnormal_inner_ear0.67839264
111MP0003705_abnormal_hypodermis_morpholog0.66620098
112MP0002822_catalepsy0.66286636
113MP0003718_maternal_effect0.65605721
114MP0010234_abnormal_vibrissa_follicle0.65043736
115MP0002928_abnormal_bile_duct0.64733452
116MP0005535_abnormal_body_temperature0.64208774
117MP0006036_abnormal_mitochondrial_physio0.63473494
118MP0010368_abnormal_lymphatic_system0.62613506
119MP0002971_abnormal_brown_adipose0.62245915
120MP0002136_abnormal_kidney_physiology0.61104824
121MP0005266_abnormal_metabolism0.59723194
122MP0005670_abnormal_white_adipose0.58689805
123MP0009053_abnormal_anal_canal0.56844667
124MP0000538_abnormal_urinary_bladder0.56773668
125MP0001765_abnormal_ion_homeostasis0.53634421
126MP0005395_other_phenotype0.53069622
127MP0003953_abnormal_hormone_level0.52328559
128MP0002132_abnormal_respiratory_system0.48886737
129MP0005248_abnormal_Harderian_gland0.47517314
130MP0001661_extended_life_span0.46502259
131MP0000579_abnormal_nail_morphology0.46444508
132MP0000639_abnormal_adrenal_gland0.46081116
133MP0005166_decreased_susceptibility_to0.45603936
134MP0005464_abnormal_platelet_physiology0.43445034
135MP0000462_abnormal_digestive_system0.43106409
136MP0003638_abnormal_response/metabolism_0.42766027
137MP0001944_abnormal_pancreas_morphology0.39814811
138MP0010155_abnormal_intestine_physiology0.39169315
139MP0000230_abnormal_systemic_arterial0.38698140
140MP0002796_impaired_skin_barrier0.37733929
141MP0008872_abnormal_physiological_respon0.37509863
142MP0003724_increased_susceptibility_to0.37317549
143MP0006035_abnormal_mitochondrial_morpho0.37116460
144MP0000566_synostosis0.35976452
145MP0008873_increased_physiological_sensi0.35786258
146MP0001663_abnormal_digestive_system0.35606382
147MP0001845_abnormal_inflammatory_respons0.35509328
148MP0003690_abnormal_glial_cell0.35205727
149MP0003300_gastrointestinal_ulcer0.34940287
150MP0005381_digestive/alimentary_phenotyp0.33626775
151MP0006082_CNS_inflammation0.32813432
152MP0001881_abnormal_mammary_gland0.32392002
153MP0002693_abnormal_pancreas_physiology0.32095609
154MP0009115_abnormal_fat_cell0.30995290
155MP0003436_decreased_susceptibility_to0.30788574
156MP0002168_other_aberrant_phenotype0.29923163
157MP0009384_cardiac_valve_regurgitation0.29753778
158MP0004130_abnormal_muscle_cell0.29691039
159MP0008874_decreased_physiological_sensi0.28455100
160MP0005666_abnormal_adipose_tissue0.27587251

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.23649241
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.98313586
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.47896983
4Deep venous thrombosis (HP:0002625)6.42384777
5Hypobetalipoproteinemia (HP:0003563)6.36176341
6Prolonged partial thromboplastin time (HP:0003645)6.05886801
7Xanthomatosis (HP:0000991)5.87663734
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.88756853
9Conjugated hyperbilirubinemia (HP:0002908)4.78844080
10Hyperlipoproteinemia (HP:0010980)4.66761770
11Complement deficiency (HP:0004431)4.64697031
12Hypolipoproteinemia (HP:0010981)4.59858477
13Fat malabsorption (HP:0002630)4.49163347
14Joint hemorrhage (HP:0005261)4.44594499
15Hyperammonemia (HP:0001987)4.38287947
16Epidermoid cyst (HP:0200040)4.36659126
17Hyperglycinemia (HP:0002154)4.22438663
18Hyperglycinuria (HP:0003108)4.16124651
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15465914
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.13612958
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11830855
22Hypoglycemic coma (HP:0001325)4.10602737
23Ketosis (HP:0001946)4.09677465
24Abnormality of the common coagulation pathway (HP:0010990)4.06579778
25Abnormality of glycine metabolism (HP:0010895)3.92841771
26Abnormality of serine family amino acid metabolism (HP:0010894)3.92841771
27Abnormality of methionine metabolism (HP:0010901)3.79729537
28Hypoalphalipoproteinemia (HP:0003233)3.73840440
29Abnormality of pyrimidine metabolism (HP:0004353)3.68781441
30Abnormality of the intrinsic pathway (HP:0010989)3.66144786
31Decreased circulating renin level (HP:0003351)3.56581748
32Congenital stationary night blindness (HP:0007642)3.51982143
33Hypercholesterolemia (HP:0003124)3.50489546
34Pancreatic cysts (HP:0001737)3.42274559
35Abnormality of complement system (HP:0005339)3.35052799
36Hyperbilirubinemia (HP:0002904)3.34266167
37Hypothermia (HP:0002045)3.34205547
38Abnormality of fatty-acid metabolism (HP:0004359)3.27924502
39Abnormality of nucleobase metabolism (HP:0010932)3.27013035
40Ketoacidosis (HP:0001993)3.24579925
41Abnormality of vitamin B metabolism (HP:0004340)3.22672488
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17428843
43Acanthocytosis (HP:0001927)3.14271696
44Abolished electroretinogram (ERG) (HP:0000550)3.13366632
45Congenital sensorineural hearing impairment (HP:0008527)3.10670029
46Abnormality of the vitamin B12 metabolism (HP:0004341)3.08712657
47Hypoglycemic seizures (HP:0002173)3.07779579
48Steatorrhea (HP:0002570)3.07448605
49Abnormality of purine metabolism (HP:0004352)3.06128832
50Abnormality of the renal cortex (HP:0011035)3.02327179
51Pancreatic fibrosis (HP:0100732)3.01542734
52True hermaphroditism (HP:0010459)3.00277883
53Metabolic alkalosis (HP:0200114)2.97965658
54Metabolic acidosis (HP:0001942)2.93849736
55Confusion (HP:0001289)2.88943401
56Molar tooth sign on MRI (HP:0002419)2.88537277
57Abnormality of midbrain morphology (HP:0002418)2.88537277
58Abnormality of serum amino acid levels (HP:0003112)2.85172454
59Pendular nystagmus (HP:0012043)2.83102518
60Malnutrition (HP:0004395)2.82468435
61Type II lissencephaly (HP:0007260)2.82088766
62Hepatocellular carcinoma (HP:0001402)2.79888475
63Delayed CNS myelination (HP:0002188)2.76108870
64Vascular calcification (HP:0004934)2.74273535
65Hyperventilation (HP:0002883)2.71279716
66Myocardial infarction (HP:0001658)2.70439881
67Hypochromic microcytic anemia (HP:0004840)2.70396781
68Abnormality of renin-angiotensin system (HP:0000847)2.66377865
69Spontaneous abortion (HP:0005268)2.65552185
70Pigmentary retinal degeneration (HP:0001146)2.63426083
71Dicarboxylic aciduria (HP:0003215)2.63256964
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63256964
73Lethargy (HP:0001254)2.63139202
74Gout (HP:0001997)2.58934908
75Hydroxyprolinuria (HP:0003080)2.58716532
76Abnormality of proline metabolism (HP:0010907)2.58716532
77Nephronophthisis (HP:0000090)2.54865777
78Skin nodule (HP:0200036)2.52215417
79Generalized aminoaciduria (HP:0002909)2.49764352
80Systemic lupus erythematosus (HP:0002725)2.49502709
81Hyperinsulinemic hypoglycemia (HP:0000825)2.46451915
82Decreased electroretinogram (ERG) amplitude (HP:0000654)2.46024182
83Attenuation of retinal blood vessels (HP:0007843)2.44578619
84Late onset (HP:0003584)2.42693201
85Symptomatic seizures (HP:0011145)2.39313030
86Cardiovascular calcification (HP:0011915)2.38789143
87Irritability (HP:0000737)2.38652006
88Decreased central vision (HP:0007663)2.36243450
89Methylmalonic aciduria (HP:0012120)2.33520636
90Pancreatitis (HP:0001733)2.32251060
91Chorioretinal atrophy (HP:0000533)2.32055638
92Renal cortical cysts (HP:0000803)2.31214949
93Abnormality of urine glucose concentration (HP:0011016)2.30709347
94Glycosuria (HP:0003076)2.30709347
95Proximal tubulopathy (HP:0000114)2.28910207
96Abnormal gallbladder morphology (HP:0012437)2.28402303
97Abnormality of the renal medulla (HP:0100957)2.28162889
98Cerebral edema (HP:0002181)2.26873477
99Congenital, generalized hypertrichosis (HP:0004540)2.26733717
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25575305
101Abnormality of alanine metabolism (HP:0010916)2.25575305
102Hyperalaninemia (HP:0003348)2.25575305
103Alkalosis (HP:0001948)2.25547811
104Glomerulonephritis (HP:0000099)2.23300274
105Poikilocytosis (HP:0004447)2.22539221
106Enlarged kidneys (HP:0000105)2.21853405
107Abnormal gallbladder physiology (HP:0012438)2.20823083
108Cholecystitis (HP:0001082)2.20823083
109Cystic liver disease (HP:0006706)2.20731212
110Rickets (HP:0002748)2.19307661
111Abnormal rod and cone electroretinograms (HP:0008323)2.17262977
112Cholelithiasis (HP:0001081)2.17100592
113Mitral stenosis (HP:0001718)2.16448630
114Tubular atrophy (HP:0000092)2.15067818
115Sensorimotor neuropathy (HP:0007141)2.13102123
116Abnormal enzyme/coenzyme activity (HP:0012379)2.12570860
117Chronic hepatic failure (HP:0100626)2.11970542
118Menorrhagia (HP:0000132)2.11925502
119Hyperglycemia (HP:0003074)2.09529103
120Esophageal varix (HP:0002040)2.07630703
121Potter facies (HP:0002009)2.07486560
122Facial shape deformation (HP:0011334)2.07486560
123Gingival bleeding (HP:0000225)2.07318183
124Recurrent gram-negative bacterial infections (HP:0005420)2.06778388
125Vomiting (HP:0002013)2.06434073
126Methylmalonic acidemia (HP:0002912)2.06393514
127Abnormality of vitamin metabolism (HP:0100508)2.06388216
128Hyperactive renin-angiotensin system (HP:0000841)2.06275309
129Progressive cerebellar ataxia (HP:0002073)2.05094453
130Cerebellar dysplasia (HP:0007033)2.04638702
131Keratoconus (HP:0000563)2.02691858
132Increased corneal curvature (HP:0100692)2.02691858
133Large for gestational age (HP:0001520)2.02483562
134Neonatal onset (HP:0003623)1.99473476
135Hyperphosphaturia (HP:0003109)1.98399039
136Medial flaring of the eyebrow (HP:0010747)1.97754127
137Spastic diplegia (HP:0001264)1.96649074
138Amyloidosis (HP:0011034)1.95585232
139Hypophosphatemic rickets (HP:0004912)1.95148385
140Brushfield spots (HP:0001088)1.94033028
141Acute encephalopathy (HP:0006846)1.93609216
142Hepatic necrosis (HP:0002605)1.93460158
143Opisthotonus (HP:0002179)1.92218910
144Inability to walk (HP:0002540)1.91744070
145Chronic diarrhea (HP:0002028)1.91529775
146Abnormality of alkaline phosphatase activity (HP:0004379)1.91086336
147Hyperuricemia (HP:0002149)1.90810860
148Increased purine levels (HP:0004368)1.90810860
149Furrowed tongue (HP:0000221)1.88230230
150Polydipsia (HP:0001959)1.87958691
151Abnormal drinking behavior (HP:0030082)1.87958691
152Ileus (HP:0002595)1.87541549
153Gaze-evoked nystagmus (HP:0000640)1.86743384
154Elevated alkaline phosphatase (HP:0003155)1.85986255
155Hypoalbuminemia (HP:0003073)1.84681608
156Abnormal albumin level (HP:0012116)1.84681608
157Abnormal urine output (HP:0012590)1.81042201
158Hyperaldosteronism (HP:0000859)1.79566896
159Abnormality of the pons (HP:0007361)1.78206119
160Stomach cancer (HP:0012126)1.77785005
161Severe muscular hypotonia (HP:0006829)1.76461071
162Fair hair (HP:0002286)1.76431595
163Hypoplasia of the pons (HP:0012110)1.75932349
164Widely patent fontanelles and sutures (HP:0004492)1.75803259
165Mitochondrial inheritance (HP:0001427)1.75405495
1663-Methylglutaconic aciduria (HP:0003535)1.74577806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.35355338
2TAOK35.27672815
3ACVR1B4.92291513
4INSRR4.17315826
5SIK13.80601997
6FRK3.77438202
7FGFR43.48190892
8ADRBK23.38793687
9ERN13.34906736
10BMPR1B3.00921169
11ERBB42.88293427
12MST1R2.79962885
13STK392.56825657
14ZAK2.45348282
15LATS12.34756581
16CASK2.32508389
17TLK12.14775151
18MAP4K22.12824962
19TNIK1.90269526
20STK38L1.83025950
21MAP3K141.77024712
22PIK3CG1.76435548
23MAPK111.72462539
24MAP2K41.61335856
25IRAK31.57529043
26FLT31.55270444
27PTK61.46093960
28PIK3CA1.45412626
29PRKAA21.38322295
30TXK1.36558838
31MAPK131.32892565
32TYK21.31730851
33NEK91.30359274
34MAP3K41.24164142
35GRK61.23827136
36NUAK11.20007387
37ABL21.17715637
38DYRK21.15711858
39PRKG21.15358342
40PAK31.15119013
41CAMKK21.08851585
42ERBB21.07991288
43AKT31.07512211
44MAP3K71.01412408
45EPHA20.98951186
46JAK20.98188449
47BRSK20.97630050
48PRKCE0.97272321
49MAPK150.92713260
50ADRBK10.90540354
51EPHA30.89678767
52PRKCG0.88652235
53JAK10.88367899
54TBK10.87918232
55MST40.86780862
56PRKAA10.86359381
57DAPK20.85860301
58NTRK30.85785728
59SGK30.84860424
60MET0.83605913
61MAP2K20.83566633
62MAP2K60.83137371
63SGK20.82523187
64TAF10.81904543
65LMTK20.77615696
66PKN20.77188440
67VRK10.76656341
68PINK10.75491163
69FGFR20.74938261
70PRKCZ0.72171265
71IKBKE0.71752832
72PHKG20.70072858
73PHKG10.70072858
74PRKCI0.69458751
75RIPK10.69283120
76MAP3K20.67645902
77PRKACG0.66584130
78CAMK2G0.66386977
79EPHB20.65941926
80IKBKB0.65699483
81MUSK0.65566497
82MAP3K30.65382853
83GRK10.64735300
84NME10.64674574
85KDR0.64151911
86MAP2K70.63130049
87PTK20.62667940
88CSK0.62569459
89CSNK1G20.61328619
90CAMK1D0.61314235
91MAPK40.59776520
92DYRK1B0.58721739
93MAP3K100.58372110
94MAP3K60.57934214
95SGK2230.57262473
96SGK4940.57262473
97NEK20.56766194
98MAP3K130.56640204
99CSNK1A10.56612124
100MARK10.56005227
101GSK3A0.54670700
102PTK2B0.53829784
103STK240.53827218
104MKNK20.53002962
105VRK20.52582946
106MAPKAPK30.52547353
107IRAK10.51984635
108TIE10.51929340
109CAMK2A0.50479380
110WNK40.50473266
111WNK30.49799286
112MAP3K10.48763092
113MAPKAPK50.47966040
114PRKCQ0.47844610
115CSNK1G30.47419786
116CDK60.46543802
117CHUK0.46539456
118SIK30.46161799
119BCR0.44332133
120TRIM280.43275758
121STK110.42995327
122GRK50.42119869
123MAP3K110.40905316
124MAP2K10.40536125
125IGF1R0.40305505
126FGFR30.39242377
127PRKG10.39196096
128NTRK20.39123391
129TGFBR10.39018681
130IRAK20.38837534
131CSNK1A1L0.38051280
132PRKCA0.37858310
133EPHB10.37777069
134CAMK2D0.37360710
135STK30.36875635
136MAP2K30.35368804
137ERBB30.35080358
138PDPK10.34884042
139TEC0.34795211
140NLK0.34669851
141TAOK20.32911881
142PBK0.32564607
143MATK0.31519151
144ITK0.30768288
145MAPK70.30709872
146MAP3K50.30331225
147IRAK40.30054948
148RPS6KA50.29436399
149CSNK1G10.29398435
150CAMK40.26420586
151FER0.23765392
152STK160.22910247
153MYLK0.22890002
154EPHA40.21464221
155OXSR10.21298796
156PRKACA0.19745650

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.11331669
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50482606
3Nitrogen metabolism_Homo sapiens_hsa009103.16047789
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86708167
5Arginine biosynthesis_Homo sapiens_hsa002202.83123720
6Tryptophan metabolism_Homo sapiens_hsa003802.79692432
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42641039
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41598203
9Complement and coagulation cascades_Homo sapiens_hsa046102.41063126
10Fatty acid degradation_Homo sapiens_hsa000712.40532743
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39764186
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30389417
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29347896
14Butanoate metabolism_Homo sapiens_hsa006502.23281185
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.23192033
16Histidine metabolism_Homo sapiens_hsa003402.11960869
17Peroxisome_Homo sapiens_hsa041462.05233475
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.99428049
19Sulfur metabolism_Homo sapiens_hsa009201.98874765
20Chemical carcinogenesis_Homo sapiens_hsa052041.93538235
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93367669
22Caffeine metabolism_Homo sapiens_hsa002321.83420162
23PPAR signaling pathway_Homo sapiens_hsa033201.81908539
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.81863071
25Propanoate metabolism_Homo sapiens_hsa006401.81787712
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80896420
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.79207657
28beta-Alanine metabolism_Homo sapiens_hsa004101.72336338
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71178860
30Retinol metabolism_Homo sapiens_hsa008301.71035888
31Fat digestion and absorption_Homo sapiens_hsa049751.70583539
32Fatty acid metabolism_Homo sapiens_hsa012121.64893841
33Bile secretion_Homo sapiens_hsa049761.64755133
34Starch and sucrose metabolism_Homo sapiens_hsa005001.60399242
35Selenocompound metabolism_Homo sapiens_hsa004501.57868355
36Phenylalanine metabolism_Homo sapiens_hsa003601.52423987
37Staphylococcus aureus infection_Homo sapiens_hsa051501.50835951
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.50297758
39Folate biosynthesis_Homo sapiens_hsa007901.49281448
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44247429
41Vitamin digestion and absorption_Homo sapiens_hsa049771.36320084
42ABC transporters_Homo sapiens_hsa020101.33909061
43Tyrosine metabolism_Homo sapiens_hsa003501.33812236
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31347773
45Phototransduction_Homo sapiens_hsa047441.31157520
46Pyruvate metabolism_Homo sapiens_hsa006201.30458868
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27232148
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15365076
49Steroid biosynthesis_Homo sapiens_hsa001001.12993359
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12610246
51Fatty acid elongation_Homo sapiens_hsa000621.11923748
52Oxidative phosphorylation_Homo sapiens_hsa001901.11874299
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.10676326
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09040941
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.07686443
56Arginine and proline metabolism_Homo sapiens_hsa003301.03643724
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02936874
58Carbon metabolism_Homo sapiens_hsa012001.00778270
59Biosynthesis of amino acids_Homo sapiens_hsa012300.96261422
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95899044
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94831351
62Nicotine addiction_Homo sapiens_hsa050330.84152326
63Lysine degradation_Homo sapiens_hsa003100.82734199
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82125108
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80730398
66Glutathione metabolism_Homo sapiens_hsa004800.78579752
67Glycerolipid metabolism_Homo sapiens_hsa005610.74290494
68Sulfur relay system_Homo sapiens_hsa041220.73512341
69Vitamin B6 metabolism_Homo sapiens_hsa007500.72137401
70Parkinsons disease_Homo sapiens_hsa050120.69389822
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68571120
72Protein export_Homo sapiens_hsa030600.65721394
73Insulin secretion_Homo sapiens_hsa049110.63311148
74Serotonergic synapse_Homo sapiens_hsa047260.60914422
75Galactose metabolism_Homo sapiens_hsa000520.60585705
76One carbon pool by folate_Homo sapiens_hsa006700.59322316
77Taste transduction_Homo sapiens_hsa047420.54408685
78Sphingolipid metabolism_Homo sapiens_hsa006000.51463816
79Pentose phosphate pathway_Homo sapiens_hsa000300.50596760
80Asthma_Homo sapiens_hsa053100.49536025
81Metabolic pathways_Homo sapiens_hsa011000.49192219
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47748881
83Fructose and mannose metabolism_Homo sapiens_hsa000510.46056882
84Cardiac muscle contraction_Homo sapiens_hsa042600.43146817
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43046737
86Alzheimers disease_Homo sapiens_hsa050100.42878449
87Fatty acid biosynthesis_Homo sapiens_hsa000610.39446778
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38392937
89Pancreatic secretion_Homo sapiens_hsa049720.38033062
90Linoleic acid metabolism_Homo sapiens_hsa005910.35380831
91Mineral absorption_Homo sapiens_hsa049780.34408498
92Huntingtons disease_Homo sapiens_hsa050160.34108421
93Morphine addiction_Homo sapiens_hsa050320.34003263
94Olfactory transduction_Homo sapiens_hsa047400.33950860
95Homologous recombination_Homo sapiens_hsa034400.33844003
96Type I diabetes mellitus_Homo sapiens_hsa049400.30488620
97Renin-angiotensin system_Homo sapiens_hsa046140.28610886
98Basal transcription factors_Homo sapiens_hsa030220.27511471
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26854312
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26526591
101Salivary secretion_Homo sapiens_hsa049700.24778076
102Glutamatergic synapse_Homo sapiens_hsa047240.24112210
103Insulin resistance_Homo sapiens_hsa049310.23112355
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.20884706
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20677081
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.20661516
107Prion diseases_Homo sapiens_hsa050200.18060128
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.15542119
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05608605
110Glucagon signaling pathway_Homo sapiens_hsa049220.05418373
111Arachidonic acid metabolism_Homo sapiens_hsa005900.01640765
112Protein digestion and absorption_Homo sapiens_hsa049740.00398854
113Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1725107
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1644396
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1605803
116Ether lipid metabolism_Homo sapiens_hsa00565-0.1505270
117Insulin signaling pathway_Homo sapiens_hsa04910-0.1448851
118Circadian rhythm_Homo sapiens_hsa04710-0.1435172
119Regulation of autophagy_Homo sapiens_hsa04140-0.1245933
120Type II diabetes mellitus_Homo sapiens_hsa04930-0.1037894
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1010732
122Hepatitis C_Homo sapiens_hsa05160-0.0967232
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0919047
124Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0897768
125AMPK signaling pathway_Homo sapiens_hsa04152-0.0523647
126African trypanosomiasis_Homo sapiens_hsa05143-0.0293587
127Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0214079
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0153948

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