ANKZF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.69538403
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.69538403
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.40223420
4L-phenylalanine catabolic process (GO:0006559)5.40223420
5indole-containing compound catabolic process (GO:0042436)5.39729560
6indolalkylamine catabolic process (GO:0046218)5.39729560
7tryptophan catabolic process (GO:0006569)5.39729560
8L-phenylalanine metabolic process (GO:0006558)5.27837447
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.27837447
10aromatic amino acid family catabolic process (GO:0009074)5.24276316
11valine metabolic process (GO:0006573)5.16167019
12negative thymic T cell selection (GO:0045060)5.10113776
13kynurenine metabolic process (GO:0070189)5.03053797
14tryptophan metabolic process (GO:0006568)5.01676114
15negative T cell selection (GO:0043383)4.98773529
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94608460
17regulation of gamma-delta T cell differentiation (GO:0045586)4.90691522
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78081193
19response to interleukin-15 (GO:0070672)4.78023377
20glyoxylate metabolic process (GO:0046487)4.75228638
21regulation of gamma-delta T cell activation (GO:0046643)4.74983313
22antigen processing and presentation of endogenous antigen (GO:0019883)4.68340565
23amino-acid betaine metabolic process (GO:0006577)4.61359953
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.43277361
25protein carboxylation (GO:0018214)4.33711973
26peptidyl-glutamic acid carboxylation (GO:0017187)4.33711973
27positive thymic T cell selection (GO:0045059)4.29641253
28histone H3-K36 demethylation (GO:0070544)4.29376874
29activated T cell proliferation (GO:0050798)4.27305781
30alpha-linolenic acid metabolic process (GO:0036109)4.24918004
31bile acid biosynthetic process (GO:0006699)4.23185858
32phospholipid efflux (GO:0033700)4.22856120
33dicarboxylic acid biosynthetic process (GO:0043650)4.18947991
34positive regulation of granulocyte differentiation (GO:0030854)4.18094593
35lysine metabolic process (GO:0006553)4.16696757
36lysine catabolic process (GO:0006554)4.16696757
37positive T cell selection (GO:0043368)4.15877789
38urea cycle (GO:0000050)4.15050189
39urea metabolic process (GO:0019627)4.15050189
40thymic T cell selection (GO:0045061)4.13720383
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.07657527
42cellular response to interleukin-15 (GO:0071350)4.05703310
43B cell receptor signaling pathway (GO:0050853)4.00041625
44regulation of B cell receptor signaling pathway (GO:0050855)3.98647341
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.97574572
46alpha-amino acid catabolic process (GO:1901606)3.94339312
472-oxoglutarate metabolic process (GO:0006103)3.94067373
48tricarboxylic acid metabolic process (GO:0072350)3.91106834
49T cell selection (GO:0045058)3.90936580
50carnitine metabolic process (GO:0009437)3.87562808
51tolerance induction (GO:0002507)3.85247376
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.78017961
53aromatic amino acid family metabolic process (GO:0009072)3.77111777
54nitrogen cycle metabolic process (GO:0071941)3.76162811
55cysteine metabolic process (GO:0006534)3.75248739
56glycine metabolic process (GO:0006544)3.73685848
57histone H4 deacetylation (GO:0070933)3.71696262
58plasma lipoprotein particle assembly (GO:0034377)3.71264094
59serine family amino acid catabolic process (GO:0009071)3.70778919
60sulfur amino acid catabolic process (GO:0000098)3.68677887
61high-density lipoprotein particle remodeling (GO:0034375)3.66051930
62positive regulation of CREB transcription factor activity (GO:0032793)3.65150981
63cellular amino acid catabolic process (GO:0009063)3.57591784
64interferon-gamma production (GO:0032609)3.53935606
65indolalkylamine metabolic process (GO:0006586)3.53365840
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52508704
67antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52508704
68bile acid metabolic process (GO:0008206)3.49689326
69oxaloacetate metabolic process (GO:0006107)3.48557587
70cellular modified amino acid catabolic process (GO:0042219)3.42446944
71aspartate family amino acid catabolic process (GO:0009068)3.40419591
72positive regulation by symbiont of host defense response (GO:0052509)3.39254164
73modulation by symbiont of host defense response (GO:0052031)3.39254164
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.39254164
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.39254164
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.39254164
77modulation by symbiont of host immune response (GO:0052553)3.39254164
78glutamate metabolic process (GO:0006536)3.37462838
79serine family amino acid biosynthetic process (GO:0009070)3.36707386
80mannose metabolic process (GO:0006013)3.36420160
81serine family amino acid metabolic process (GO:0009069)3.35599426
82cellular biogenic amine catabolic process (GO:0042402)3.34650773
83amine catabolic process (GO:0009310)3.34650773
84fructose metabolic process (GO:0006000)3.34392567
85regulation of cholesterol homeostasis (GO:2000188)3.34122382
86negative regulation of T cell mediated immunity (GO:0002710)3.34098493
87histone H3 deacetylation (GO:0070932)3.32525153
88protein-lipid complex assembly (GO:0065005)3.31442011
89negative regulation of cholesterol transport (GO:0032375)3.29315450
90negative regulation of sterol transport (GO:0032372)3.29315450
91branched-chain amino acid metabolic process (GO:0009081)3.28687288
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.28604687
93branched-chain amino acid catabolic process (GO:0009083)3.28601084
94regulation of protein activation cascade (GO:2000257)3.27986782
95poly(A)+ mRNA export from nucleus (GO:0016973)3.27417833
96histone H3-K9 modification (GO:0061647)3.26951415
97NAD biosynthetic process (GO:0009435)3.26835190
98pentose-phosphate shunt (GO:0006098)3.26393025
99complement activation, alternative pathway (GO:0006957)3.25911039
100pyridine nucleotide biosynthetic process (GO:0019363)3.25730072
101nicotinamide nucleotide biosynthetic process (GO:0019359)3.25730072
102histone H3-K9 demethylation (GO:0033169)3.24835514
103negative regulation of leukocyte mediated immunity (GO:0002704)3.24277337
104negative regulation of fibrinolysis (GO:0051918)3.24247508
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.23788881
106benzene-containing compound metabolic process (GO:0042537)3.23728505
107fatty acid beta-oxidation (GO:0006635)3.23536959
108regulation of ARF protein signal transduction (GO:0032012)3.22447150
109disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.22052616
110killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.22052616
111histone H3-K4 trimethylation (GO:0080182)3.21974114
112coenzyme catabolic process (GO:0009109)3.21562235
113cilium or flagellum-dependent cell motility (GO:0001539)3.21100459
114phospholipid homeostasis (GO:0055091)3.20047059
115imidazole-containing compound metabolic process (GO:0052803)3.19503612
116carboxylic acid catabolic process (GO:0046395)3.19078559
117organic acid catabolic process (GO:0016054)3.19078559
118plasma lipoprotein particle remodeling (GO:0034369)3.18862737
119protein-lipid complex remodeling (GO:0034368)3.18862737
120macromolecular complex remodeling (GO:0034367)3.18862737
121homocysteine metabolic process (GO:0050667)3.18012308
122NAD metabolic process (GO:0019674)3.17590224
123fatty acid oxidation (GO:0019395)3.17360560
124detection of bacterium (GO:0016045)3.15529560
125negative regulation of B cell mediated immunity (GO:0002713)3.15084806
126negative regulation of immunoglobulin mediated immune response (GO:0002890)3.15084806
127ethanol oxidation (GO:0006069)3.13871826
128regulation of B cell differentiation (GO:0045577)3.12949981
129urate metabolic process (GO:0046415)3.12821088
130negative regulation of bone resorption (GO:0045779)3.12747083
131carnitine shuttle (GO:0006853)3.12043285
132lipid oxidation (GO:0034440)3.11733982
133reverse cholesterol transport (GO:0043691)3.11316887
134regulation of triglyceride catabolic process (GO:0010896)3.09445351
135antigen receptor-mediated signaling pathway (GO:0050851)3.09422965
136cholesterol efflux (GO:0033344)3.09208238
137fatty acid transmembrane transport (GO:1902001)3.08665489
138regulation of fibrinolysis (GO:0051917)3.08170246
139acylglycerol homeostasis (GO:0055090)3.07253137
140triglyceride homeostasis (GO:0070328)3.07253137
141tyrosine metabolic process (GO:0006570)3.06982040
142fatty acid catabolic process (GO:0009062)3.06843044
143leukocyte aggregation (GO:0070486)3.04231244
144positive regulation of tolerance induction (GO:0002645)3.03641034
145regulation of complement activation (GO:0030449)3.02507636
146monocarboxylic acid catabolic process (GO:0072329)3.01979415
147misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.00290630
148mast cell activation (GO:0045576)2.99168314
149nucleotide salvage (GO:0043173)2.98540764
150drug catabolic process (GO:0042737)2.97521180
151positive regulation of respiratory burst (GO:0060267)2.97121603
152regulation of histone H3-K27 methylation (GO:0061085)2.95784723
153regulation of regulatory T cell differentiation (GO:0045589)2.95733718
154positive regulation of gamma-delta T cell activation (GO:0046645)2.95181504
155drug transmembrane transport (GO:0006855)2.93499153
156dicarboxylic acid metabolic process (GO:0043648)2.92526896
157negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.90749193
158very-low-density lipoprotein particle assembly (GO:0034379)2.87223891
159regulation of granulocyte differentiation (GO:0030852)2.86180185
160histone lysine demethylation (GO:0070076)2.84766036
161response to muramyl dipeptide (GO:0032495)2.83565867
162detection of other organism (GO:0098543)2.82529931
163regulation of tolerance induction (GO:0002643)2.81006999
164positive regulation of B cell differentiation (GO:0045579)2.80747298
165regulation of T cell tolerance induction (GO:0002664)2.80746113
166histone demethylation (GO:0016577)2.79930465
167histone H3-K9 methylation (GO:0051567)2.77718937
168T cell receptor signaling pathway (GO:0050852)2.76040149
169negative regulation of adaptive immune response (GO:0002820)2.75231393
170mucosal-associated lymphoid tissue development (GO:0048537)2.74584514
171Peyers patch development (GO:0048541)2.74584514
172regulation of T cell mediated cytotoxicity (GO:0001914)2.67937988
173regulation of alpha-beta T cell proliferation (GO:0046640)2.67092181
174T cell migration (GO:0072678)2.65172773
175regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64554838
176regulation of natural killer cell mediated immunity (GO:0002715)2.64554838
177positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64100815
178positive regulation of Rap GTPase activity (GO:0032854)2.63161925
179mast cell degranulation (GO:0043303)2.61828716
180mast cell activation involved in immune response (GO:0002279)2.61828716
181immunoglobulin mediated immune response (GO:0016064)2.61680262
182negative regulation of innate immune response (GO:0045824)2.60156471
183positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60108573
184axonemal dynein complex assembly (GO:0070286)2.59968338
185epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58575033
186natural killer cell differentiation (GO:0001779)2.57319253
187negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57024369
188positive regulation of histone deacetylation (GO:0031065)2.55317791
189modulation by virus of host process (GO:0019054)2.51474602
190protein demethylation (GO:0006482)2.50933928
191protein dealkylation (GO:0008214)2.50933928
192macroautophagy (GO:0016236)2.49777642
193negative regulation of cAMP-mediated signaling (GO:0043951)2.49437344
194regulation of beta-amyloid formation (GO:1902003)2.49234226
195energy homeostasis (GO:0097009)2.48644722
196lung epithelium development (GO:0060428)2.47886077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.71464009
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.52664244
3GATA1_22025678_ChIP-Seq_K562_Human4.44208227
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.27945400
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.60935242
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.31389021
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20309648
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.95533289
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.94219445
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.68506085
11E2F7_22180533_ChIP-Seq_HELA_Human2.67154602
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.65811319
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51926448
14MYC_22102868_ChIP-Seq_BL_Human2.48531260
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.33559042
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25600865
17* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.24046454
18VDR_21846776_ChIP-Seq_THP-1_Human2.20627163
19SCL_19346495_ChIP-Seq_HPC-7_Human2.19128867
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13010196
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10663760
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.97853083
23MYB_26560356_Chip-Seq_TH2_Human1.96433318
24DROSHA_22980978_ChIP-Seq_HELA_Human1.93349697
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90195709
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86119207
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83488011
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75823249
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74818752
30GATA3_27048872_Chip-Seq_THYMUS_Human1.70089290
31SMC4_20622854_ChIP-Seq_HELA_Human1.69091555
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.69068675
33CIITA_25753668_ChIP-Seq_RAJI_Human1.68538009
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.68445280
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67691802
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.66923253
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64287820
38GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60408463
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59484055
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58202232
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54475453
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50777104
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50625260
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49024954
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46825234
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43367274
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.43331988
48MAF_26560356_Chip-Seq_TH1_Human1.43313791
49TCF7_22412390_ChIP-Seq_EML_Mouse1.43073093
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40524579
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38289062
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37683547
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37098803
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35476613
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33839826
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33676606
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33521153
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32874948
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31874787
60OCT4_19829295_ChIP-Seq_ESCs_Human1.31674134
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31023301
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.30957339
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.29260326
64UTX_26944678_Chip-Seq_JUKART_Human1.28218459
65* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27357280
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26871268
67* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26382451
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.26006203
69CREB1_26743006_Chip-Seq_LNCaP_Human1.24262942
70* RARB_24833708_ChIP-Seq_LIVER_Mouse1.23718381
71SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.23460401
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20403791
73* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19551837
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.18989846
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18839450
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.18752824
77* NCOR1_26117541_ChIP-Seq_K562_Human1.18382961
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17296973
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17127791
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.16026980
81* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15670602
82GATA3_26560356_Chip-Seq_TH2_Human1.15438298
83SA1_27219007_Chip-Seq_Bcells_Human1.14452790
84MYB_26560356_Chip-Seq_TH1_Human1.14135512
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13290220
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13120623
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12247302
88ERA_21632823_ChIP-Seq_H3396_Human1.12237252
89ELF1_20517297_ChIP-Seq_JURKAT_Human1.12099738
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.10563835
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10103904
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09585008
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07621072
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07121903
95OCT4_20526341_ChIP-Seq_ESCs_Human1.06882500
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06813858
97ETS1_21867929_ChIP-Seq_TH2_Mouse1.06316735
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06099404
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05834701
100MYC_18555785_ChIP-Seq_MESCs_Mouse1.05070660
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04993567
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04907740
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.04672690
104P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04329785
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03987841
106BCL6_27268052_Chip-Seq_Bcells_Human1.02967556
107* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02828346
108* RUNX1_22412390_ChIP-Seq_EML_Mouse1.02765157
109RAC3_21632823_ChIP-Seq_H3396_Human1.02360468
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02200700
111KDM2B_26808549_Chip-Seq_K562_Human1.01718604
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01618901
113LXR_22292898_ChIP-Seq_THP-1_Human1.01105589
114BCOR_27268052_Chip-Seq_Bcells_Human1.01059609
115CLOCK_20551151_ChIP-Seq_293T_Human1.00675162
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00591236
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00477713
118SPI1_23547873_ChIP-Seq_NB4_Human0.99897834
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.99038329
120TFEB_21752829_ChIP-Seq_HELA_Human0.98713409
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97716340
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97291154
123PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96984945
124VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96174385
125* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96035116
126VDR_24763502_ChIP-Seq_THP-1_Human0.95829570
127P68_20966046_ChIP-Seq_HELA_Human0.95676853
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95658989
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95520392
130HNF4A_19822575_ChIP-Seq_HepG2_Human0.95312949
131MAF_26560356_Chip-Seq_TH2_Human0.95216485
132* FOXP3_21729870_ChIP-Seq_TREG_Human0.93203678
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92588834
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91693239
135RUNX_20019798_ChIP-Seq_JUKART_Human0.91650958
136RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89750894
137PHF8_20622854_ChIP-Seq_HELA_Human0.89199989
138P300_27268052_Chip-Seq_Bcells_Human0.88448391
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86411360
140KDM5A_27292631_Chip-Seq_BREAST_Human0.85919013
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84974420
142E2F1_20622854_ChIP-Seq_HELA_Human0.84560219
143KDM2B_26808549_Chip-Seq_DND41_Human0.84432446
144ETS1_20019798_ChIP-Seq_JURKAT_Human0.83168711
145* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83046043
146GATA1_19941826_ChIP-Seq_K562_Human0.82272350
147SPI1_23127762_ChIP-Seq_K562_Human0.82256102
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81379605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.87040637
2MP0002139_abnormal_hepatobiliary_system4.99956001
3MP0005365_abnormal_bile_salt4.88834212
4MP0005085_abnormal_gallbladder_physiolo4.28570578
5MP0010329_abnormal_lipoprotein_level3.32038008
6MP0008875_abnormal_xenobiotic_pharmacok3.09544701
7MP0003787_abnormal_imprinting3.04502442
8MP0003763_abnormal_thymus_physiology2.97885338
9MP0003806_abnormal_nucleotide_metabolis2.95616357
10MP0003252_abnormal_bile_duct2.68802853
11MP0003122_maternal_imprinting2.60185262
12MP0009840_abnormal_foam_cell2.47120512
13MP0001986_abnormal_taste_sensitivity2.38381875
14MP0001790_abnormal_immune_system2.37742761
15MP0005387_immune_system_phenotype2.37742761
16MP0005332_abnormal_amino_acid2.34222991
17MP0002653_abnormal_ependyma_morphology2.28779659
18MP0008995_early_reproductive_senescence2.21760879
19MP0003191_abnormal_cellular_cholesterol2.15207884
20MP0001666_abnormal_nutrient_absorption2.11828326
21MP0001764_abnormal_homeostasis2.10899029
22MP0004381_abnormal_hair_follicle2.06592583
23MP0005000_abnormal_immune_tolerance1.98503408
24MP0002132_abnormal_respiratory_system1.98074808
25MP0000609_abnormal_liver_physiology1.97385329
26MP0006036_abnormal_mitochondrial_physio1.95755180
27MP0002118_abnormal_lipid_homeostasis1.93031612
28MP0005377_hearing/vestibular/ear_phenot1.87746120
29MP0003878_abnormal_ear_physiology1.87746120
30MP0003724_increased_susceptibility_to1.82907597
31MP0004019_abnormal_vitamin_homeostasis1.76313348
32MP0005319_abnormal_enzyme/_coenzyme1.73039793
33MP0005584_abnormal_enzyme/coenzyme_acti1.72783942
34MP0003172_abnormal_lysosome_physiology1.72665008
35MP0000703_abnormal_thymus_morphology1.70220877
36MP0009333_abnormal_splenocyte_physiolog1.63834552
37MP0004145_abnormal_muscle_electrophysio1.62830428
38MP0008260_abnormal_autophagy1.62301015
39MP0005645_abnormal_hypothalamus_physiol1.60866101
40MP0005464_abnormal_platelet_physiology1.60129225
41MP0005083_abnormal_biliary_tract1.55725332
42MP0004084_abnormal_cardiac_muscle1.54540943
43MP0002405_respiratory_system_inflammati1.50773076
44MP0003866_abnormal_defecation1.47353837
45MP0004130_abnormal_muscle_cell1.46886912
46MP0004043_abnormal_pH_regulation1.45890928
47MP0003123_paternal_imprinting1.45175356
48MP0009697_abnormal_copulation1.44921527
49MP0003303_peritoneal_inflammation1.42738299
50MP0005310_abnormal_salivary_gland1.40296121
51MP0001661_extended_life_span1.38185531
52MP0003121_genomic_imprinting1.36122900
53MP0009643_abnormal_urine_homeostasis1.36060541
54MP0001835_abnormal_antigen_presentation1.35655683
55MP0002254_reproductive_system_inflammat1.34373922
56MP0005423_abnormal_somatic_nervous1.34233243
57MP0001873_stomach_inflammation1.32487961
58MP0002396_abnormal_hematopoietic_system1.29853407
59MP0004036_abnormal_muscle_relaxation1.29704893
60MP0005551_abnormal_eye_electrophysiolog1.29154764
61MP0008877_abnormal_DNA_methylation1.28910160
62MP0008961_abnormal_basal_metabolism1.27218737
63MP0002933_joint_inflammation1.23914995
64MP0001800_abnormal_humoral_immune1.23884841
65MP0005670_abnormal_white_adipose1.23703941
66MP0000598_abnormal_liver_morphology1.21737695
67MP0001502_abnormal_circadian_rhythm1.20713636
68MP0004147_increased_porphyrin_level1.17901339
69MP0000685_abnormal_immune_system1.17512634
70MP0006035_abnormal_mitochondrial_morpho1.16514149
71MP0001968_abnormal_touch/_nociception1.12375740
72MP0009785_altered_susceptibility_to1.12283409
73MP0006054_spinal_hemorrhage1.10954743
74MP0000689_abnormal_spleen_morphology1.10621042
75MP0008469_abnormal_protein_level1.08599312
76MP0004264_abnormal_extraembryonic_tissu1.08043180
77MP0003656_abnormal_erythrocyte_physiolo1.07060770
78MP0002166_altered_tumor_susceptibility1.04956373
79MP0002928_abnormal_bile_duct1.04017232
80MP0005671_abnormal_response_to1.03390692
81MP0002971_abnormal_brown_adipose1.03044888
82MP0005174_abnormal_tail_pigmentation1.02967294
83MP0009672_abnormal_birth_weight1.02004476
84MP0003436_decreased_susceptibility_to1.01535058
85MP0005266_abnormal_metabolism1.00213674
86MP0009642_abnormal_blood_homeostasis0.99454371
87MP0001984_abnormal_olfaction0.99444658
88MP0001348_abnormal_lacrimal_gland0.98466115
89MP0000569_abnormal_digit_pigmentation0.95438243
90MP0002136_abnormal_kidney_physiology0.94846661
91MP0002722_abnormal_immune_system0.92442657
92MP0005451_abnormal_body_composition0.92346053
93MP0002398_abnormal_bone_marrow0.90602070
94MP0004742_abnormal_vestibular_system0.90096376
95MP0005058_abnormal_lysosome_morphology0.88673701
96MP0003868_abnormal_feces_composition0.88356273
97MP0002452_abnormal_antigen_presenting0.87521682
98MP0004808_abnormal_hematopoietic_stem0.87322577
99MP0009763_increased_sensitivity_to0.87274599
100MP0002138_abnormal_hepatobiliary_system0.86738077
101MP0003329_amyloid_beta_deposits0.86196852
102MP0002723_abnormal_immune_serum0.85998126
103MP0003011_delayed_dark_adaptation0.85931323
104MP0002009_preneoplasia0.85581030
105MP0005376_homeostasis/metabolism_phenot0.85354140
106MP0010155_abnormal_intestine_physiology0.84176060
107MP0000716_abnormal_immune_system0.83668198
108MP0003566_abnormal_cell_adhesion0.83029673
109MP0008775_abnormal_heart_ventricle0.83027111
110MP0001765_abnormal_ion_homeostasis0.82428816
111MP0005636_abnormal_mineral_homeostasis0.82299647
112MP0002429_abnormal_blood_cell0.82220286
113MP0002419_abnormal_innate_immunity0.81906274
114MP0002089_abnormal_postnatal_growth/wei0.81374478
115MP0008569_lethality_at_weaning0.81033568
116MP0002420_abnormal_adaptive_immunity0.80349542
117MP0009764_decreased_sensitivity_to0.79000170
118MP0001533_abnormal_skeleton_physiology0.78498663
119MP0002078_abnormal_glucose_homeostasis0.77980672
120MP0001819_abnormal_immune_cell0.77348659
121MP0002557_abnormal_social/conspecific_i0.77030090
122MP0002970_abnormal_white_adipose0.76768336
123MP0004947_skin_inflammation0.75448019
124MP0001663_abnormal_digestive_system0.73525269
125MP0003183_abnormal_peptide_metabolism0.73007541
126MP0003943_abnormal_hepatobiliary_system0.72969586
127MP0005025_abnormal_response_to0.72968814
128MP0001845_abnormal_inflammatory_respons0.72677926
129MP0003195_calcinosis0.72507346
130MP0005535_abnormal_body_temperature0.72477837
131MP0005075_abnormal_melanosome_morpholog0.71811335
132MP0008874_decreased_physiological_sensi0.71020902
133MP0001324_abnormal_eye_pigmentation0.70260967
134MP0000749_muscle_degeneration0.70157434
135MP0003705_abnormal_hypodermis_morpholog0.69980184
136MP0010307_abnormal_tumor_latency0.69627195
137MP0005330_cardiomyopathy0.69407588
138MP0005666_abnormal_adipose_tissue0.69208258
139MP0002693_abnormal_pancreas_physiology0.69089791
140MP0008872_abnormal_physiological_respon0.68764038
141MP0003567_abnormal_fetal_cardiomyocyte0.67580669
142MP0000566_synostosis0.67059439
143MP0000230_abnormal_systemic_arterial0.66313720
144MP0000604_amyloidosis0.65615081
145MP0002277_abnormal_respiratory_mucosa0.65563065
146MP0005499_abnormal_olfactory_system0.64274368
147MP0005394_taste/olfaction_phenotype0.64274368
148MP0009115_abnormal_fat_cell0.63995446
149MP0010630_abnormal_cardiac_muscle0.63779739
150MP0001756_abnormal_urination0.63468414
151MP0001851_eye_inflammation0.63172009
152MP0004133_heterotaxia0.62639767
153MP0002063_abnormal_learning/memory/cond0.61537769
154MP0003880_abnormal_central_pattern0.60152808
155MP0002064_seizures0.57417871

Predicted human phenotypes

RankGene SetZ-score
1Hyperlipoproteinemia (HP:0010980)4.86739800
2Prolonged partial thromboplastin time (HP:0003645)4.65880839
3Intrahepatic cholestasis (HP:0001406)4.31069456
4Xanthomatosis (HP:0000991)4.16072095
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.09163362
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.05206627
7Ketosis (HP:0001946)4.01621974
8Deep venous thrombosis (HP:0002625)3.95013685
9Congenital stationary night blindness (HP:0007642)3.73350681
10Abnormality of the common coagulation pathway (HP:0010990)3.72582020
11Eczematoid dermatitis (HP:0000976)3.69960358
12Joint hemorrhage (HP:0005261)3.69433447
13Hypobetalipoproteinemia (HP:0003563)3.65889609
14Myositis (HP:0100614)3.48539338
15Pustule (HP:0200039)3.47861528
16Hyperammonemia (HP:0001987)3.39116776
17Elevated erythrocyte sedimentation rate (HP:0003565)3.36162086
18Recurrent fungal infections (HP:0002841)3.25597395
19Panhypogammaglobulinemia (HP:0003139)3.25145108
20Gastrointestinal infarctions (HP:0005244)3.20872657
21Hyperglycinuria (HP:0003108)3.20824881
22Papilledema (HP:0001085)3.20525669
23Abnormality of the intrinsic pathway (HP:0010989)3.20312196
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.20249563
25Abnormal respiratory motile cilium morphology (HP:0005938)3.17895226
26Abnormal respiratory epithelium morphology (HP:0012253)3.17895226
27Chronic mucocutaneous candidiasis (HP:0002728)3.16036516
28Recurrent cutaneous fungal infections (HP:0011370)3.16036516
29Absent/shortened dynein arms (HP:0200106)3.09868886
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.09868886
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.08260213
32Ragged-red muscle fibers (HP:0003200)3.02620017
33Encephalitis (HP:0002383)3.01747313
34Abnormality of serine family amino acid metabolism (HP:0010894)3.00946520
35Abnormality of glycine metabolism (HP:0010895)3.00946520
36Hypercholesterolemia (HP:0003124)2.99096565
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.98298457
38Retrobulbar optic neuritis (HP:0100654)2.98045063
39Optic neuritis (HP:0100653)2.98045063
40Agammaglobulinemia (HP:0004432)2.96793824
41Asplenia (HP:0001746)2.92911468
42Hyperbilirubinemia (HP:0002904)2.92763563
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.92149389
44Gout (HP:0001997)2.87809279
45Meningitis (HP:0001287)2.87233017
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.86786270
47Ketoacidosis (HP:0001993)2.85657498
48Orchitis (HP:0100796)2.84557029
49Recurrent bacterial skin infections (HP:0005406)2.81926620
50Hypoglycemic coma (HP:0001325)2.80830207
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79769188
52Abnormality of fatty-acid metabolism (HP:0004359)2.79625267
53Abnormality of pyrimidine metabolism (HP:0004353)2.77521304
54Lymphopenia (HP:0001888)2.74599081
55Delayed CNS myelination (HP:0002188)2.74490977
56Hyperglycinemia (HP:0002154)2.73737557
57Increased IgE level (HP:0003212)2.71599783
58Abnormal gallbladder physiology (HP:0012438)2.71090184
59Cholecystitis (HP:0001082)2.71090184
60Chronic otitis media (HP:0000389)2.69558485
61Recurrent gram-negative bacterial infections (HP:0005420)2.68084390
62Hypolipoproteinemia (HP:0010981)2.67967547
63Complement deficiency (HP:0004431)2.67334330
64Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67275776
65Vasculitis (HP:0002633)2.66463817
66Abnormality of methionine metabolism (HP:0010901)2.65418582
67Hepatocellular carcinoma (HP:0001402)2.64472248
68Colitis (HP:0002583)2.63592156
69Bronchiectasis (HP:0002110)2.63077366
70Abnormality of T cells (HP:0002843)2.62790763
71Recurrent abscess formation (HP:0002722)2.55850776
72Myoglobinuria (HP:0002913)2.54456685
73Hypochromic anemia (HP:0001931)2.54369712
74Prolonged bleeding time (HP:0003010)2.54127212
75Severe combined immunodeficiency (HP:0004430)2.52406382
76Recurrent skin infections (HP:0001581)2.51565053
77Abnormality of nucleobase metabolism (HP:0010932)2.48043233
78Epistaxis (HP:0000421)2.45719123
79Mediastinal lymphadenopathy (HP:0100721)2.44296616
80Late onset (HP:0003584)2.44293252
81Fat malabsorption (HP:0002630)2.43088972
82T lymphocytopenia (HP:0005403)2.42371491
83Reticulocytosis (HP:0001923)2.38776779
84Abnormal ciliary motility (HP:0012262)2.37524375
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37252681
86Dicarboxylic aciduria (HP:0003215)2.37252681
87Abnormality of purine metabolism (HP:0004352)2.33304198
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.33268025
89Bronchitis (HP:0012387)2.31913040
90Hypoalphalipoproteinemia (HP:0003233)2.31699653
91Recurrent otitis media (HP:0000403)2.31669678
92Type II lissencephaly (HP:0007260)2.30273767
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.28563943
94Abnormal respiratory motile cilium physiology (HP:0012261)2.28490672
95IgM deficiency (HP:0002850)2.26434563
96Chronic sinusitis (HP:0011109)2.25618699
97Abnormal platelet function (HP:0011869)2.20982578
98Impaired platelet aggregation (HP:0003540)2.20982578
99Conjugated hyperbilirubinemia (HP:0002908)2.20319140
100Seborrheic dermatitis (HP:0001051)2.19699710
101Cholelithiasis (HP:0001081)2.18892947
102Gastrointestinal inflammation (HP:0004386)2.18831217
103Metabolic acidosis (HP:0001942)2.18782338
104Generalized aminoaciduria (HP:0002909)2.17806954
105Chronic obstructive pulmonary disease (HP:0006510)2.17023202
106Obstructive lung disease (HP:0006536)2.17023202
107Abnormality of T cell number (HP:0011839)2.15549191
108Keratoconjunctivitis (HP:0001096)2.15329376
109Bile duct proliferation (HP:0001408)2.15290714
110Abnormal biliary tract physiology (HP:0012439)2.15290714
111Status epilepticus (HP:0002133)2.14626953
112Cerebral edema (HP:0002181)2.13893844
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12054489
114Basal cell carcinoma (HP:0002671)2.11323869
115Vascular calcification (HP:0004934)2.10507528
116Thrombocytosis (HP:0001894)2.10325671
117Abnormal gallbladder morphology (HP:0012437)2.10074815
118Neonatal onset (HP:0003623)2.09058156
119Cerebellar dysplasia (HP:0007033)2.08422399
120Upper motor neuron abnormality (HP:0002127)2.08106240
121Inflammation of the large intestine (HP:0002037)2.07588920
122Increased IgM level (HP:0003496)2.06826987
123Global brain atrophy (HP:0002283)2.05844165
124Spontaneous abortion (HP:0005268)2.04804829
125Abnormality of macrophages (HP:0004311)2.03886616
126Hemorrhage of the eye (HP:0011885)2.03684268
127Poikilocytosis (HP:0004447)2.03472529
128Hypoglycemic seizures (HP:0002173)2.03006652
129Abnormality of the fingertips (HP:0001211)2.02734787
130Stomatitis (HP:0010280)2.00210569
131Abnormality of the lower motor neuron (HP:0002366)1.99573261
132Chronic hepatic failure (HP:0100626)1.98814228
133Pigmentary retinal degeneration (HP:0001146)1.98239192
134Epidermoid cyst (HP:0200040)1.97986144
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.97100222
136Pulmonary infiltrates (HP:0002113)1.96688925
137IgG deficiency (HP:0004315)1.95302922
138Cerebral palsy (HP:0100021)1.94521993
139Recurrent bronchitis (HP:0002837)1.93886432
140Elevated hepatic transaminases (HP:0002910)1.93699273
141Broad alveolar ridges (HP:0000187)1.92118561
142Verrucae (HP:0200043)1.92038510
143Papilloma (HP:0012740)1.92038510
144Spastic diplegia (HP:0001264)1.91312410
145Rhabdomyolysis (HP:0003201)1.90763977
146Abnormality of the peritoneum (HP:0002585)1.90588172
147Abnormality of T cell physiology (HP:0011840)1.90360101
148Pancreatic islet-cell hyperplasia (HP:0004510)1.89971859
149Gingival bleeding (HP:0000225)1.89943666
150Urticaria (HP:0001025)1.89267858
151Abnormality of the pleura (HP:0002103)1.87249916
152Asymmetric septal hypertrophy (HP:0001670)1.87066957
153Acute hepatic failure (HP:0006554)1.86366884
154Broad palm (HP:0001169)1.85601154
155Keratoconjunctivitis sicca (HP:0001097)1.84807567
156Abnormality of the heme biosynthetic pathway (HP:0010472)1.84682894
157Abnormality of complement system (HP:0005339)1.83911056
158Deep palmar crease (HP:0006191)1.82070403
159Lethargy (HP:0001254)1.81450136
160Gastrointestinal stroma tumor (HP:0100723)1.80538461
161Exercise-induced muscle cramps (HP:0003710)1.80274819
162Abnormality of the pancreatic islet cells (HP:0006476)1.79757178
163Abnormality of endocrine pancreas physiology (HP:0012093)1.79757178
164Recurrent sinusitis (HP:0011108)1.79263843
165Rhinitis (HP:0012384)1.79084837
166Pulmonary embolism (HP:0002204)1.78262267
167Recurrent viral infections (HP:0004429)1.78034852
168Epileptic encephalopathy (HP:0200134)1.77710769
169Atrioventricular block (HP:0001678)1.77556520
170Opisthotonus (HP:0002179)1.77432535
171Vomiting (HP:0002013)1.77421676
172Tubulointerstitial nephritis (HP:0001970)1.76663476
173Abnormality of reticulocytes (HP:0004312)1.75985141
174Nasal polyposis (HP:0100582)1.75762270
175Abnormality of serum amino acid levels (HP:0003112)1.75013855
176Chronic diarrhea (HP:0002028)1.74848864
177Progressive cerebellar ataxia (HP:0002073)1.74108177
178Cystic liver disease (HP:0006706)1.73987874
179Tented upper lip vermilion (HP:0010804)1.73846801
180Thrombophlebitis (HP:0004418)1.73739861
181Abnormal rod and cone electroretinograms (HP:0008323)1.73419339
182Steatorrhea (HP:0002570)1.73046552
183Albinism (HP:0001022)1.71000112
184Lissencephaly (HP:0001339)1.70746775
185Chronic bronchitis (HP:0004469)1.68673823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.00317416
2BCKDK3.75685475
3MAP4K13.10841023
4SRPK13.09436831
5FLT32.80941697
6ERN12.77215241
7TXK2.53072618
8NEK12.35637392
9TYK22.28643811
10EEF2K2.28611252
11GRK62.25971782
12INSRR2.03841577
13FGFR42.02010661
14EPHA32.00647461
15WNK41.95429060
16MAP3K131.92294928
17FGFR21.79904109
18BRD41.72347461
19FGFR31.70788931
20TGFBR21.61840527
21CSF1R1.57397455
22TAOK31.54425307
23MAP3K71.50389573
24TYRO31.48583879
25TRIB31.46002921
26SIK11.44243556
27SIK31.42762689
28IRAK41.42376923
29MARK21.37270312
30MAP2K31.36399530
31KIT1.32482681
32IRAK31.32374479
33SIK21.32133241
34CDK191.30096575
35BLK1.29931799
36NTRK21.29554939
37BTK1.28433557
38PRPF4B1.26984990
39CDC42BPA1.25317065
40MAPK111.22858358
41CDK121.21419568
42IKBKE1.11375562
43MUSK1.10571703
44RIPK41.10140318
45EPHB11.10032650
46STK101.09099558
47SYK1.08971088
48NEK21.03351181
49MYLK1.01554139
50JAK11.00842851
51TEC1.00579160
52SGK31.00521216
53MAP3K100.99401383
54MAPK150.98787925
55MST1R0.98089606
56SGK2230.97682648
57SGK4940.97682648
58FES0.96991293
59CAMKK20.96721392
60WNK10.94420419
61TTN0.93941976
62RET0.91658441
63PDK10.91516983
64PDK40.90996055
65PDK30.90996055
66MAPK70.89830470
67TNIK0.89539448
68DYRK1B0.88225294
69TBK10.87317155
70MAP3K110.86484336
71ICK0.85673626
72HIPK20.83686124
73TNK20.80859001
74MAP2K20.80749252
75JAK20.77778881
76STK40.76888693
77PRKAA20.76797643
78CDK40.76346190
79LMTK20.75342521
80MAPK120.74731865
81PIK3CA0.72127801
82JAK30.71052347
83LRRK20.70443503
84ATR0.70282968
85FGR0.69584114
86CCNB10.67747038
87NLK0.67529334
88STK110.67201385
89MAP2K60.64143736
90CAMK40.64027874
91PIM10.63421901
92OBSCN0.63396840
93OXSR10.62792696
94RPS6KB20.62422114
95HCK0.61769733
96DAPK20.61719495
97ACVR1B0.61246434
98ITK0.60790930
99PRKCI0.60476724
100PRKD20.60415626
101LCK0.60156407
102GRK10.59782612
103RPS6KC10.59176216
104RPS6KL10.59176216
105PRKCZ0.58582886
106MAP3K10.57986000
107NEK60.57731467
108MATK0.56897810
109PRKCH0.56859975
110MAP2K40.55698797
111ZAP700.55605798
112RPS6KA60.55151150
113LYN0.54821204
114PINK10.54516928
115MTOR0.53973589
116FYN0.53759792
117CDC70.52488267
118DYRK1A0.50866772
119SGK20.50388632
120TRPM70.50109074
121DAPK10.49986120
122ERBB20.48411858
123MAP3K140.48271340
124TSSK60.47891788
125PDPK10.47094818
126CHUK0.45232005
127MARK30.44874298
128PDK20.44030721
129TGFBR10.43076428
130PASK0.41753926
131GRK70.41181321
132PRKCQ0.37453161
133CDK60.36880756
134PTK60.36730458
135CAMK10.36389790
136ARAF0.34742303
137ALK0.34149324
138CAMKK10.34121953
139AKT20.34003572
140RPS6KA20.32967573
141CSK0.32404874
142MAPK40.30641543
143PRKAA10.30295613
144IKBKB0.29918091
145PTK2B0.29444231

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.62316167
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09187745
3Fatty acid degradation_Homo sapiens_hsa000712.79562749
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.73174701
5Allograft rejection_Homo sapiens_hsa053302.72740118
6Graft-versus-host disease_Homo sapiens_hsa053322.69875969
7Autoimmune thyroid disease_Homo sapiens_hsa053202.69705304
8Caffeine metabolism_Homo sapiens_hsa002322.66341796
9Arginine biosynthesis_Homo sapiens_hsa002202.59176562
10Nitrogen metabolism_Homo sapiens_hsa009102.58187938
11Tryptophan metabolism_Homo sapiens_hsa003802.51525355
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50570994
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.41271089
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39385694
15Propanoate metabolism_Homo sapiens_hsa006402.33854517
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29942426
17Fatty acid metabolism_Homo sapiens_hsa012122.23885068
18Type I diabetes mellitus_Homo sapiens_hsa049402.18124007
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14833230
20Biosynthesis of amino acids_Homo sapiens_hsa012302.14551224
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13710120
22T cell receptor signaling pathway_Homo sapiens_hsa046602.05908442
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.95079244
24Carbon metabolism_Homo sapiens_hsa012001.91433969
25Peroxisome_Homo sapiens_hsa041461.89459154
26Leishmaniasis_Homo sapiens_hsa051401.86973953
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.85004932
28Lysine degradation_Homo sapiens_hsa003101.84225822
29Pyruvate metabolism_Homo sapiens_hsa006201.78056925
30Complement and coagulation cascades_Homo sapiens_hsa046101.77650337
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77615826
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75560748
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73265448
34Antigen processing and presentation_Homo sapiens_hsa046121.70952443
35ABC transporters_Homo sapiens_hsa020101.70053245
36PPAR signaling pathway_Homo sapiens_hsa033201.69926165
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62633296
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62351411
39Selenocompound metabolism_Homo sapiens_hsa004501.60270341
40Fatty acid elongation_Homo sapiens_hsa000621.56242720
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55272967
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55023886
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.53675316
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51985083
45Asthma_Homo sapiens_hsa053101.49351926
46Fructose and mannose metabolism_Homo sapiens_hsa000511.47497998
47Butanoate metabolism_Homo sapiens_hsa006501.46842268
48Pentose phosphate pathway_Homo sapiens_hsa000301.44770840
49beta-Alanine metabolism_Homo sapiens_hsa004101.44608037
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44448248
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42936070
52Bile secretion_Homo sapiens_hsa049761.42270690
53Osteoclast differentiation_Homo sapiens_hsa043801.38493616
54Linoleic acid metabolism_Homo sapiens_hsa005911.38383602
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36443263
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.33423961
57Measles_Homo sapiens_hsa051621.31664156
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.31651535
59Glycerolipid metabolism_Homo sapiens_hsa005611.29411367
60Staphylococcus aureus infection_Homo sapiens_hsa051501.27518096
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26506709
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24012816
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23205847
64Starch and sucrose metabolism_Homo sapiens_hsa005001.22376770
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22055394
66Chemical carcinogenesis_Homo sapiens_hsa052041.17872613
67Hematopoietic cell lineage_Homo sapiens_hsa046401.17473324
68Notch signaling pathway_Homo sapiens_hsa043301.17442121
69Inositol phosphate metabolism_Homo sapiens_hsa005621.15960434
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09149202
71Viral myocarditis_Homo sapiens_hsa054161.09022027
72mTOR signaling pathway_Homo sapiens_hsa041501.08911873
73One carbon pool by folate_Homo sapiens_hsa006701.07964297
74Jak-STAT signaling pathway_Homo sapiens_hsa046301.05011539
75Histidine metabolism_Homo sapiens_hsa003401.04932916
76Tuberculosis_Homo sapiens_hsa051521.04734542
77Phenylalanine metabolism_Homo sapiens_hsa003601.04332802
78Choline metabolism in cancer_Homo sapiens_hsa052311.03964085
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03261062
80Ether lipid metabolism_Homo sapiens_hsa005651.03009240
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01241333
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00844875
83VEGF signaling pathway_Homo sapiens_hsa043700.98822809
84Folate biosynthesis_Homo sapiens_hsa007900.96060085
85Phototransduction_Homo sapiens_hsa047440.95428705
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95134526
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95118138
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93344071
89Vitamin B6 metabolism_Homo sapiens_hsa007500.93243336
90Influenza A_Homo sapiens_hsa051640.91656017
91Chemokine signaling pathway_Homo sapiens_hsa040620.90519375
92Galactose metabolism_Homo sapiens_hsa000520.86927304
93Retinol metabolism_Homo sapiens_hsa008300.84616596
94Regulation of autophagy_Homo sapiens_hsa041400.82559766
95Tyrosine metabolism_Homo sapiens_hsa003500.80808149
96Fat digestion and absorption_Homo sapiens_hsa049750.78844596
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78181958
98Hepatitis C_Homo sapiens_hsa051600.77556365
99Vitamin digestion and absorption_Homo sapiens_hsa049770.75185401
100Toxoplasmosis_Homo sapiens_hsa051450.74827435
101Sulfur relay system_Homo sapiens_hsa041220.72255350
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.68894491
103Primary immunodeficiency_Homo sapiens_hsa053400.64966533
104FoxO signaling pathway_Homo sapiens_hsa040680.63781335
105Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63295540
106Type II diabetes mellitus_Homo sapiens_hsa049300.62817361
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.62586544
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.61079174
109DNA replication_Homo sapiens_hsa030300.60261537
110Nicotine addiction_Homo sapiens_hsa050330.60042789
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.58522892
112Glucagon signaling pathway_Homo sapiens_hsa049220.57642550
113Prolactin signaling pathway_Homo sapiens_hsa049170.57513035
114Insulin resistance_Homo sapiens_hsa049310.57273045
115Morphine addiction_Homo sapiens_hsa050320.55143949
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54801523
117Hepatitis B_Homo sapiens_hsa051610.54137889
118ErbB signaling pathway_Homo sapiens_hsa040120.53836144
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.53532329
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52072515
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51455310
122Endometrial cancer_Homo sapiens_hsa052130.51196725
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.50682138
124B cell receptor signaling pathway_Homo sapiens_hsa046620.49301324
125Base excision repair_Homo sapiens_hsa034100.49193971
126Endocytosis_Homo sapiens_hsa041440.48852859
127Epstein-Barr virus infection_Homo sapiens_hsa051690.47056740
128GnRH signaling pathway_Homo sapiens_hsa049120.46324059
129Viral carcinogenesis_Homo sapiens_hsa052030.46227122
130Metabolic pathways_Homo sapiens_hsa011000.46088978
131Non-homologous end-joining_Homo sapiens_hsa034500.44623722
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40850082
133MAPK signaling pathway_Homo sapiens_hsa040100.40725822
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.40444165
135Colorectal cancer_Homo sapiens_hsa052100.39079744
136Maturity onset diabetes of the young_Homo sapiens_hsa049500.38624124
137Ovarian steroidogenesis_Homo sapiens_hsa049130.36172087
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.35550465
139Arginine and proline metabolism_Homo sapiens_hsa003300.35052239
140Platelet activation_Homo sapiens_hsa046110.34509861
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33578278
142Arachidonic acid metabolism_Homo sapiens_hsa005900.33136035
143Glutathione metabolism_Homo sapiens_hsa004800.32795353
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30992829
145Insulin secretion_Homo sapiens_hsa049110.30922246
146Chronic myeloid leukemia_Homo sapiens_hsa052200.30030194
147Ras signaling pathway_Homo sapiens_hsa040140.29979425
148Apoptosis_Homo sapiens_hsa042100.29565049
149Fatty acid biosynthesis_Homo sapiens_hsa000610.27762802
150Circadian rhythm_Homo sapiens_hsa047100.27260871
151Mismatch repair_Homo sapiens_hsa034300.23054748
152Other glycan degradation_Homo sapiens_hsa005110.13585755
153Non-small cell lung cancer_Homo sapiens_hsa052230.12069074
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10150624
155Insulin signaling pathway_Homo sapiens_hsa049100.09833988
156Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08538610
157Intestinal immune network for IgA production_Homo sapiens_hsa046720.08104273
158HIF-1 signaling pathway_Homo sapiens_hsa040660.07575997
159Herpes simplex infection_Homo sapiens_hsa051680.07513291
160AMPK signaling pathway_Homo sapiens_hsa041520.07021177
161Thyroid hormone synthesis_Homo sapiens_hsa049180.06734103
162N-Glycan biosynthesis_Homo sapiens_hsa005100.05929654
163Sulfur metabolism_Homo sapiens_hsa009200.05898092
164Acute myeloid leukemia_Homo sapiens_hsa052210.03479732
165Purine metabolism_Homo sapiens_hsa002300.01810896
166Nucleotide excision repair_Homo sapiens_hsa034200.01596259
167Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0043685

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