ANO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.16482430
2pattern specification involved in kidney development (GO:0061004)5.48233996
3desmosome organization (GO:0002934)4.97697077
4mesodermal cell differentiation (GO:0048333)4.58241945
5bundle of His cell to Purkinje myocyte communication (GO:0086069)4.45736184
6atrioventricular valve morphogenesis (GO:0003181)4.45675442
7establishment of skin barrier (GO:0061436)4.37681930
8sexual reproduction (GO:0019953)4.27923555
9endocardial cushion morphogenesis (GO:0003203)3.89365101
10epithelial cell-cell adhesion (GO:0090136)3.88013551
11hypotonic response (GO:0006971)3.87116849
12type B pancreatic cell proliferation (GO:0044342)3.80671358
13cell adhesion mediated by integrin (GO:0033627)3.79076397
14renal filtration (GO:0097205)3.76988404
15ectoderm development (GO:0007398)3.74341841
16endothelial cell chemotaxis (GO:0035767)3.69000525
17cell-substrate junction assembly (GO:0007044)3.64816202
18dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.57542951
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.57529111
20interferon-gamma secretion (GO:0072643)3.54600736
21negative regulation of cell fate specification (GO:0009996)3.53264798
22growth hormone receptor signaling pathway (GO:0060396)3.50980783
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.50538461
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.43495271
25regulation of cell fate specification (GO:0042659)3.35816536
26fibrinolysis (GO:0042730)3.28016935
27glomerular visceral epithelial cell development (GO:0072015)3.27901044
28mesenchyme morphogenesis (GO:0072132)3.25894499
29heart valve morphogenesis (GO:0003179)3.22355922
30epithelial cell differentiation involved in prostate gland development (GO:0060742)3.22279647
31regulation of protein activation cascade (GO:2000257)3.21567083
32skin morphogenesis (GO:0043589)3.20778109
33glomerular basement membrane development (GO:0032836)3.19858562
34epoxygenase P450 pathway (GO:0019373)3.19361742
35complement activation, alternative pathway (GO:0006957)3.19304684
36hippo signaling (GO:0035329)3.15376090
37regulation of cardioblast differentiation (GO:0051890)3.11966514
38omega-hydroxylase P450 pathway (GO:0097267)3.11954714
39regulation of complement activation (GO:0030449)3.11075906
40lung lobe morphogenesis (GO:0060463)3.10105076
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.09331542
42water homeostasis (GO:0030104)3.08493158
43drug catabolic process (GO:0042737)3.06208824
44regulation of hippo signaling (GO:0035330)3.06088837
45cellular response to growth hormone stimulus (GO:0071378)3.04768724
46glomerular epithelial cell development (GO:0072310)3.03787264
47regulation of transforming growth factor beta1 production (GO:0032908)3.02261744
48surfactant homeostasis (GO:0043129)3.01281222
49polarized epithelial cell differentiation (GO:0030859)3.00700347
50tight junction assembly (GO:0070830)2.97954331
51regulation of fibrinolysis (GO:0051917)2.94469403
52branching involved in salivary gland morphogenesis (GO:0060445)2.93912565
53exogenous drug catabolic process (GO:0042738)2.93724980
54renal system development (GO:0072001)2.93270226
55L-phenylalanine metabolic process (GO:0006558)2.91893949
56erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.91893949
57regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.91273845
58negative regulation of fatty acid transport (GO:2000192)2.91178214
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89114852
60urea metabolic process (GO:0019627)2.88826916
61regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.86780843
62negative regulation of smooth muscle cell migration (GO:0014912)2.86541262
63mammary gland epithelial cell proliferation (GO:0033598)2.86086713
64focal adhesion assembly (GO:0048041)2.85285456
65cell-substrate adherens junction assembly (GO:0007045)2.85285456
66branching involved in mammary gland duct morphogenesis (GO:0060444)2.85022063
67ethanol oxidation (GO:0006069)2.84234897
68metanephric nephron epithelium development (GO:0072243)2.84164059
69regulation of water loss via skin (GO:0033561)2.83044550
70plasma membrane repair (GO:0001778)2.82700351
71endothelial cell morphogenesis (GO:0001886)2.82536143
72face development (GO:0060324)2.80651373
73cell volume homeostasis (GO:0006884)2.79985088
74extracellular matrix assembly (GO:0085029)2.79709615
75glomerular filtration (GO:0003094)2.79621623
76positive regulation of osteoblast proliferation (GO:0033690)2.77797285
77cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77588780
78establishment of apical/basal cell polarity (GO:0035089)2.77455106
79regulation of phospholipase A2 activity (GO:0032429)2.77121576
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.77098896
81negative regulation of fibrinolysis (GO:0051918)2.76840475
82glial cell proliferation (GO:0014009)2.76683886
83regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.76178259
84gland morphogenesis (GO:0022612)2.75998691
85ethanol metabolic process (GO:0006067)2.75236976
86peptidyl-glutamic acid carboxylation (GO:0017187)2.74095136
87protein carboxylation (GO:0018214)2.74095136
88positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.73094183
89positive regulation of p38MAPK cascade (GO:1900745)2.73073741
90regulation of glucose import in response to insulin stimulus (GO:2001273)2.72323959
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71782776
92L-phenylalanine catabolic process (GO:0006559)2.71782776
93pathway-restricted SMAD protein phosphorylation (GO:0060389)2.71754233
94regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.71401053
95negative regulation of cell fate commitment (GO:0010454)2.70892998
96regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69977399
97endodermal cell differentiation (GO:0035987)2.68168804
98negative regulation of keratinocyte proliferation (GO:0010839)2.67220942
99hepatocyte apoptotic process (GO:0097284)2.67206642
100intestinal epithelial cell development (GO:0060576)2.66525344
101Golgi transport vesicle coating (GO:0048200)2.66041297
102COPI coating of Golgi vesicle (GO:0048205)2.66041297
103semaphorin-plexin signaling pathway (GO:0071526)2.65430872
104positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.62214598
105apoptotic cell clearance (GO:0043277)2.61518002
106urea cycle (GO:0000050)2.60744994
107positive regulation of endothelial cell apoptotic process (GO:2000353)2.60570280
108mammary gland epithelial cell differentiation (GO:0060644)2.59237752
109apical protein localization (GO:0045176)2.58670924
110negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.57599153
111cell-cell junction assembly (GO:0007043)2.57589795
112lung vasculature development (GO:0060426)2.57354673
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.56615492
114negative regulation of lipase activity (GO:0060192)2.56255208
115positive regulation of protein localization to plasma membrane (GO:1903078)2.56184584
116regulation of somitogenesis (GO:0014807)2.55996507
117metanephric tubule development (GO:0072170)2.55749315
118metanephric nephron tubule development (GO:0072234)2.55749315
119G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.55068173
120metanephric epithelium development (GO:0072207)2.54046004
121keratinocyte proliferation (GO:0043616)2.53376136
122mammary gland development (GO:0030879)2.53268424
123morphogenesis of embryonic epithelium (GO:0016331)2.53053190
124extracellular matrix disassembly (GO:0022617)2.52791228
125endocardial cushion development (GO:0003197)2.51706698
126cell junction assembly (GO:0034329)2.51697424
127regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.51691181
128keratinocyte differentiation (GO:0030216)2.51554974
129establishment of tissue polarity (GO:0007164)2.51378798
130establishment of planar polarity (GO:0001736)2.51378798
131chemical homeostasis within a tissue (GO:0048875)2.51339394
132protein localization to cell surface (GO:0034394)2.50419040
133lung-associated mesenchyme development (GO:0060484)2.50262206
134regulation of SMAD protein import into nucleus (GO:0060390)2.50174770
135cellular glucuronidation (GO:0052695)2.49858001
136cell migration involved in sprouting angiogenesis (GO:0002042)2.49028838
137mesonephros development (GO:0001823)2.48870510
138renal system process involved in regulation of blood volume (GO:0001977)2.48381342
139gap junction assembly (GO:0016264)2.48010518
140response to water (GO:0009415)2.47674907
141nitrogen cycle metabolic process (GO:0071941)2.47490110
142regulation of glomerular filtration (GO:0003093)2.45844584
143negative regulation of chondrocyte differentiation (GO:0032331)2.45381633
144hair cycle (GO:0042633)2.45290905
145molting cycle (GO:0042303)2.45290905
146positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.44522687
147heart valve formation (GO:0003188)2.43511085
148cell junction organization (GO:0034330)2.43393863
149substrate adhesion-dependent cell spreading (GO:0034446)2.41793654
150Notch signaling involved in heart development (GO:0061314)2.41487949
151segment specification (GO:0007379)2.40468585
152ear development (GO:0043583)2.38962003
153protein localization to endosome (GO:0036010)2.37994868
154epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.37715525
155negative regulation of blood coagulation (GO:0030195)2.37131443
156negative regulation of hemostasis (GO:1900047)2.37131443
157cardiac right ventricle morphogenesis (GO:0003215)2.36684472
158glomerulus development (GO:0032835)2.36588626
159regulation of plasminogen activation (GO:0010755)2.36035001
160membrane budding (GO:0006900)2.35857362
161collecting duct development (GO:0072044)2.35813678
162adherens junction assembly (GO:0034333)2.35093965
163multicellular organismal water homeostasis (GO:0050891)2.34908379
164peptide cross-linking (GO:0018149)2.34248585
165flavonoid metabolic process (GO:0009812)2.33987964
166basement membrane organization (GO:0071711)2.33651212
167epidermis development (GO:0008544)2.31741502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.31195345
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.74178826
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.52236581
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.38163487
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.32599937
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.30468905
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.93741937
8ZNF263_19887448_ChIP-Seq_K562_Human2.92597410
9CLOCK_20551151_ChIP-Seq_293T_Human2.63853712
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.58043332
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55138048
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38959591
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.34557496
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.23075773
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20172156
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.19874276
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19740757
18SOX9_24532713_ChIP-Seq_HFSC_Mouse2.17337030
19FOXO3_23340844_ChIP-Seq_DLD1_Human2.12560958
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.10196796
21* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.06515997
22SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98579100
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98579100
24SOX2_20726797_ChIP-Seq_SW620_Human1.97406220
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95407135
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89806996
27* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.84110502
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82335312
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82084276
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79685122
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77757194
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76870559
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.75828711
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.71200657
35LXR_22292898_ChIP-Seq_THP-1_Human1.70920950
36CJUN_26792858_Chip-Seq_BT549_Human1.69543324
37* AHR_22903824_ChIP-Seq_MCF-7_Human1.68438420
38* RUNX1_27514584_Chip-Seq_MCF-7_Human1.66869745
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65446727
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61897175
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60898434
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59694620
43GATA4_25053715_ChIP-Seq_YYC3_Human1.55752407
44RACK7_27058665_Chip-Seq_MCF-7_Human1.46327576
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43374374
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.42014944
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39574749
48* KLF5_25053715_ChIP-Seq_YYC3_Human1.39181488
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.38281466
50GATA6_25053715_ChIP-Seq_YYC3_Human1.35321626
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34386833
52ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34166313
53GATA3_24758297_ChIP-Seq_MCF-7_Human1.33647788
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32962687
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32833182
56* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32345713
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30283313
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29729369
59TBX20_22080862_ChIP-Seq_HEART_Mouse1.26040737
60TBX20_22328084_ChIP-Seq_HEART_Mouse1.26040737
61TP63_22573176_ChIP-Seq_HFKS_Human1.25671838
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24448797
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23069822
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22678664
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21643304
66GATA1_22025678_ChIP-Seq_K562_Human1.21288932
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18666394
68ATF3_27146783_Chip-Seq_COLON_Human1.17946878
69UBF1/2_26484160_Chip-Seq_HMECs_Human1.17574328
70SMC4_20622854_ChIP-Seq_HELA_Human1.15513017
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14042528
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12707145
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12520749
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12211739
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10765725
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10016887
77TP53_18474530_ChIP-ChIP_U2OS_Human1.08234354
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08222256
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08222256
80BRD4_25478319_ChIP-Seq_HGPS_Human1.07716231
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04327731
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03846923
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03018651
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.02531160
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.02038272
86FOXA2_19822575_ChIP-Seq_HepG2_Human1.01639512
87CTCF_27219007_Chip-Seq_Bcells_Human1.00539996
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00056399
89P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98914272
90LXR_22158963_ChIP-Seq_LIVER_Mouse0.98285807
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98053700
92TP53_16413492_ChIP-PET_HCT116_Human0.97398408
93TCF7_22412390_ChIP-Seq_EML_Mouse0.97246223
94* TP63_23658742_ChIP-Seq_EP156T_Human0.97184907
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97176774
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97126475
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96593703
98* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96581605
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.96519164
100* ISL1_27105846_Chip-Seq_CPCs_Mouse0.95848363
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95443926
102WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95368570
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92281452
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91561632
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89712408
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.89712245
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89092742
108* KDM2B_26808549_Chip-Seq_K562_Human0.88693604
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88205355
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.87891102
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86535458
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86185324
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85649974
114PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85313017
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84179750
116CREB1_26743006_Chip-Seq_LNCaP_Human0.84079332
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82610806
118* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82488605
119NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82249753
120ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81872850
121RXR_22108803_ChIP-Seq_LS180_Human0.81812716
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81574954
123TP53_22127205_ChIP-Seq_IMR90_Human0.81062242
124* TP53_23651856_ChIP-Seq_MEFs_Mouse0.80863843
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79037817
126* DROSHA_22980978_ChIP-Seq_HELA_Human0.78728387
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78256036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.93555265
2MP0005275_abnormal_skin_tensile3.34615508
3MP0004272_abnormal_basement_membrane3.15452982
4MP0003705_abnormal_hypodermis_morpholog2.93969202
5MP0001881_abnormal_mammary_gland2.91207819
6MP0000537_abnormal_urethra_morphology2.83516919
7MP0002796_impaired_skin_barrier2.65496234
8MP0003566_abnormal_cell_adhesion2.63769536
9MP0008438_abnormal_cutaneous_collagen2.41215707
10MP0002254_reproductive_system_inflammat2.35614950
11MP0004264_abnormal_extraembryonic_tissu2.28426299
12MP0003300_gastrointestinal_ulcer2.28040890
13MP0010678_abnormal_skin_adnexa2.26022779
14MP0001849_ear_inflammation2.22369116
15MP0002060_abnormal_skin_morphology2.17987612
16MP0005360_urolithiasis2.12869089
17MP0002009_preneoplasia2.12431079
18MP0010352_gastrointestinal_tract_polyps2.11618867
19MP0006054_spinal_hemorrhage2.07268317
20MP0009384_cardiac_valve_regurgitation2.00517762
21MP0000566_synostosis1.98874501
22MP0005409_darkened_coat_color1.94588534
23MP0003453_abnormal_keratinocyte_physiol1.87733438
24MP0003941_abnormal_skin_development1.84894225
25MP0002098_abnormal_vibrissa_morphology1.80288022
26MP0005501_abnormal_skin_physiology1.77796819
27MP0001958_emphysema1.70120563
28MP0002139_abnormal_hepatobiliary_system1.67870814
29MP0000627_abnormal_mammary_gland1.62273481
30MP0005085_abnormal_gallbladder_physiolo1.59688032
31MP0004381_abnormal_hair_follicle1.58577139
32MP0000762_abnormal_tongue_morphology1.57834213
33MP0005623_abnormal_meninges_morphology1.57525926
34MP0008875_abnormal_xenobiotic_pharmacok1.53084904
35MP0003878_abnormal_ear_physiology1.52206621
36MP0005377_hearing/vestibular/ear_phenot1.52206621
37MP0000751_myopathy1.52169682
38MP0003045_fibrosis1.50126590
39MP0004185_abnormal_adipocyte_glucose1.49496925
40MP0005023_abnormal_wound_healing1.46840849
41MP0003191_abnormal_cellular_cholesterol1.40905456
42MP0001216_abnormal_epidermal_layer1.40539009
43MP0005248_abnormal_Harderian_gland1.39182944
44MP0005365_abnormal_bile_salt1.38906983
45MP0000467_abnormal_esophagus_morphology1.36521042
46MP0000579_abnormal_nail_morphology1.36151224
47MP0000383_abnormal_hair_follicle1.34139142
48MP0002108_abnormal_muscle_morphology1.33255813
49MP0002166_altered_tumor_susceptibility1.31253489
50MP0002896_abnormal_bone_mineralization1.27301038
51MP0005666_abnormal_adipose_tissue1.26012068
52MP0000534_abnormal_ureter_morphology1.25256893
53MP0000377_abnormal_hair_follicle1.23690017
54MP0010771_integument_phenotype1.22373961
55MP0005257_abnormal_intraocular_pressure1.19776550
56MP0005076_abnormal_cell_differentiation1.19150187
57MP0006138_congestive_heart_failure1.18305234
58MP0002249_abnormal_larynx_morphology1.18159482
59MP0001346_abnormal_lacrimal_gland1.17892418
60MP0003868_abnormal_feces_composition1.17815112
61MP0004782_abnormal_surfactant_physiolog1.17141453
62MP0003279_aneurysm1.15679530
63MP0003091_abnormal_cell_migration1.13424287
64MP0000462_abnormal_digestive_system1.11866003
65MP0010030_abnormal_orbit_morphology1.11396186
66MP0005375_adipose_tissue_phenotype1.10557332
67MP0003115_abnormal_respiratory_system1.09441239
68MP0009780_abnormal_chondrocyte_physiolo1.05009706
69MP0003942_abnormal_urinary_system1.03993772
70MP0009053_abnormal_anal_canal1.00105486
71MP0000538_abnormal_urinary_bladder1.00065458
72MP0002295_abnormal_pulmonary_circulatio0.99854323
73MP0005508_abnormal_skeleton_morphology0.97842029
74MP0000678_abnormal_parathyroid_gland0.97266102
75MP0002877_abnormal_melanocyte_morpholog0.93543640
76MP0000003_abnormal_adipose_tissue0.93175700
77MP0004130_abnormal_muscle_cell0.92924971
78MP0002006_tumorigenesis0.92874534
79MP0002138_abnormal_hepatobiliary_system0.91116195
80MP0000516_abnormal_urinary_system0.89523822
81MP0005367_renal/urinary_system_phenotyp0.89523822
82MP0000750_abnormal_muscle_regeneration0.88575105
83MP0002168_other_aberrant_phenotype0.88040924
84MP0005330_cardiomyopathy0.86924978
85MP0001666_abnormal_nutrient_absorption0.86027930
86MP0000858_altered_metastatic_potential0.85722614
87MP0004036_abnormal_muscle_relaxation0.83205111
88MP0010368_abnormal_lymphatic_system0.82288179
89MP0001348_abnormal_lacrimal_gland0.82157645
90MP0001879_abnormal_lymphatic_vessel0.81649832
91MP0009278_abnormal_bone_marrow0.80504046
92MP0004084_abnormal_cardiac_muscle0.79926085
93MP0000733_abnormal_muscle_development0.79838779
94MP0001243_abnormal_dermal_layer0.79632925
95MP0002925_abnormal_cardiovascular_devel0.79133038
96MP0005165_increased_susceptibility_to0.79110461
97* MP0000163_abnormal_cartilage_morphology0.78132714
98MP0005670_abnormal_white_adipose0.77587007
99MP0003252_abnormal_bile_duct0.77433893
100MP0005408_hypopigmentation0.76323120
101MP0005187_abnormal_penis_morphology0.76178959
102MP0010329_abnormal_lipoprotein_level0.75872668
103MP0008004_abnormal_stomach_pH0.75387370
104MP0003936_abnormal_reproductive_system0.74372462
105MP0010630_abnormal_cardiac_muscle0.73679123
106MP0005164_abnormal_response_to0.71948373
107MP0002234_abnormal_pharynx_morphology0.71810657
108MP0004947_skin_inflammation0.71674150
109MP0005220_abnormal_exocrine_pancreas0.71291429
110MP0002089_abnormal_postnatal_growth/wei0.71280731
111MP0001614_abnormal_blood_vessel0.68719879
112MP0003950_abnormal_plasma_membrane0.67922359
113MP0000613_abnormal_salivary_gland0.67399084
114MP0004087_abnormal_muscle_fiber0.67339971
115MP0000427_abnormal_hair_cycle0.66466102
116* MP0000767_abnormal_smooth_muscle0.66144390
117MP0005083_abnormal_biliary_tract0.66048022
118MP0005167_abnormal_blood-brain_barrier0.65982616
119* MP0002282_abnormal_trachea_morphology0.65955040
120MP0003638_abnormal_response/metabolism_0.65921242
121MP0000647_abnormal_sebaceous_gland0.65757248
122MP0005503_abnormal_tendon_morphology0.64647789
123MP0005451_abnormal_body_composition0.63816161
124MP0002115_abnormal_skeleton_extremities0.63794792
125MP0009931_abnormal_skin_appearance0.63272403
126MP0001299_abnormal_eye_distance/0.63208231
127MP0000367_abnormal_coat/_hair0.62895267
128MP0000013_abnormal_adipose_tissue0.62727480
129MP0003448_altered_tumor_morphology0.61922042
130MP0005595_abnormal_vascular_smooth0.61361304
131MP0004858_abnormal_nervous_system0.60017484
132MP0002233_abnormal_nose_morphology0.60006046

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.63837685
2Onycholysis (HP:0001806)5.52871200
3Atrophic scars (HP:0001075)5.34343823
4Milia (HP:0001056)4.94574818
5Fragile nails (HP:0001808)4.36874333
6Aortic aneurysm (HP:0004942)3.94751671
7Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76897457
8Deep venous thrombosis (HP:0002625)3.75750272
9Aortic dissection (HP:0002647)3.44791775
10Plantar hyperkeratosis (HP:0007556)3.23149528
11Complement deficiency (HP:0004431)3.15769987
12Focal segmental glomerulosclerosis (HP:0000097)3.15220149
13Hypotrichosis (HP:0001006)3.13579257
14Shallow orbits (HP:0000586)3.10247013
15Fragile skin (HP:0001030)3.09615110
16Abnormality of complement system (HP:0005339)2.97685615
17Broad face (HP:0000283)2.91398516
18Selective tooth agenesis (HP:0001592)2.83469413
19Broad metatarsal (HP:0001783)2.82536611
20Glomerulosclerosis (HP:0000096)2.80450994
21Abnormality of nail color (HP:0100643)2.80358130
22Ankle contracture (HP:0006466)2.80109528
23Thick nail (HP:0001805)2.78539566
24Pili torti (HP:0003777)2.76857616
25Cerebral aneurysm (HP:0004944)2.76256583
26Abnormal hair laboratory examination (HP:0003328)2.74055178
27Interstitial pulmonary disease (HP:0006530)2.71482220
28Premature rupture of membranes (HP:0001788)2.66927189
29Alopecia of scalp (HP:0002293)2.65636452
30Arterial tortuosity (HP:0005116)2.59394465
31Rectal prolapse (HP:0002035)2.58355623
32Hypoplasia of dental enamel (HP:0006297)2.56830374
33Palmoplantar hyperkeratosis (HP:0000972)2.56602458
34Nail dystrophy (HP:0008404)2.52847787
35Hypoplastic ischia (HP:0003175)2.52208142
36Short hallux (HP:0010109)2.52119497
37Curly hair (HP:0002212)2.48068151
38Natal tooth (HP:0000695)2.48002259
39Germ cell neoplasia (HP:0100728)2.46244045
40Conjugated hyperbilirubinemia (HP:0002908)2.46212236
41Vascular tortuosity (HP:0004948)2.43135316
42Aplasia cutis congenita (HP:0001057)2.42399067
43Abnormality of the axillary hair (HP:0100134)2.42243279
44Abnormality of secondary sexual hair (HP:0009888)2.42243279
45Aneurysm (HP:0002617)2.42230685
46Ridged nail (HP:0001807)2.40760395
47Subacute progressive viral hepatitis (HP:0006572)2.39331705
48Woolly hair (HP:0002224)2.39295037
49Prolonged partial thromboplastin time (HP:0003645)2.37841026
50Abnormal vertebral ossification (HP:0100569)2.37702472
51Epiphyseal dysplasia (HP:0002656)2.37645999
52Osteolytic defects of the hand bones (HP:0009699)2.37515053
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.37515053
54Palmar hyperkeratosis (HP:0010765)2.36868001
55Protrusio acetabuli (HP:0003179)2.35802839
56Obstructive sleep apnea (HP:0002870)2.33652878
57Bronchomalacia (HP:0002780)2.33090633
58Aplasia/Hypoplasia of the hallux (HP:0008362)2.32005184
59Micronodular cirrhosis (HP:0001413)2.31781162
60Increased connective tissue (HP:0009025)2.31733457
61Hypoplasia of the iris (HP:0007676)2.30897743
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.30177924
63Pterygium (HP:0001059)2.28696820
64Distal lower limb amyotrophy (HP:0008944)2.26798569
65Cervical subluxation (HP:0003308)2.24019862
66Abnormality of the 2nd finger (HP:0004100)2.22227286
67Abnormality of the ischium (HP:0003174)2.19832446
68Aplasia involving bones of the extremities (HP:0009825)2.19086691
69Aplasia involving bones of the upper limbs (HP:0009823)2.19086691
70Aplasia of the phalanges of the hand (HP:0009802)2.19086691
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.16663837
72Ventricular tachycardia (HP:0004756)2.15611205
73Long toe (HP:0010511)2.14381744
74Humeroradial synostosis (HP:0003041)2.12651490
75Synostosis involving the elbow (HP:0003938)2.12651490
76Fused cervical vertebrae (HP:0002949)2.10054090
77Hypoalphalipoproteinemia (HP:0003233)2.09866595
78Esophageal atresia (HP:0002032)2.08883498
79Neoplasm of the heart (HP:0100544)2.08517255
80Nephritis (HP:0000123)2.06471369
81Muscle fiber splitting (HP:0003555)2.06264108
82Duplicated collecting system (HP:0000081)2.05733692
83Distal lower limb muscle weakness (HP:0009053)2.05456742
84Abnormality of molar (HP:0011077)2.05394753
85Abnormality of molar morphology (HP:0011070)2.05394753
86Mixed hearing impairment (HP:0000410)2.05056424
87Ureteral stenosis (HP:0000071)2.04395158
88Taurodontia (HP:0000679)2.04009919
89Abnormality of permanent molar morphology (HP:0011071)2.04009919
90Abnormality of the dental root (HP:0006486)2.04009919
91Mesangial abnormality (HP:0001966)2.03480051
92Abnormality of the gastric mucosa (HP:0004295)2.02869183
93Oligodontia (HP:0000677)2.02702903
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.99006506
95Severe Myopia (HP:0011003)1.97556460
96Mitral valve prolapse (HP:0001634)1.96603842
97Esophageal varix (HP:0002040)1.96385389
98Radial bowing (HP:0002986)1.94657382
99Biliary tract neoplasm (HP:0100574)1.94123260
100Soft skin (HP:0000977)1.93627559
101Abnormality of the dental pulp (HP:0006479)1.93516313
102Flat acetabular roof (HP:0003180)1.93466832
103Ureteral obstruction (HP:0006000)1.92872510
104Neonatal short-limb short stature (HP:0008921)1.91868461
105Acanthosis nigricans (HP:0000956)1.91816013
106Cardiovascular calcification (HP:0011915)1.91804869
107Abdominal distention (HP:0003270)1.90394759
108Abnormality of the distal phalanges of the toes (HP:0010182)1.90202065
109Malnutrition (HP:0004395)1.89617060
110Potter facies (HP:0002009)1.88867745
111Facial shape deformation (HP:0011334)1.88867745
112Lip pit (HP:0100267)1.87052843
113Intrahepatic cholestasis (HP:0001406)1.86077125
114Neonatal death (HP:0003811)1.85851346
115Hematochezia (HP:0002573)1.85511203
116Exostoses (HP:0100777)1.83150386
117Advanced eruption of teeth (HP:0006288)1.82959137
118Hyporeflexia of lower limbs (HP:0002600)1.81615498
119Erythema (HP:0010783)1.81055922
120Hypoplastic labia majora (HP:0000059)1.80986385
121Ureteral duplication (HP:0000073)1.79787546
122Abnormal blistering of the skin (HP:0008066)1.79036804
123Unilateral renal agenesis (HP:0000122)1.78664248
124Abnormal hemoglobin (HP:0011902)1.78109151
125Mildly elevated creatine phosphokinase (HP:0008180)1.78078543
126Amelogenesis imperfecta (HP:0000705)1.77997398
127Buphthalmos (HP:0000557)1.77910882
128Laryngomalacia (HP:0001601)1.77114371
129Follicular hyperkeratosis (HP:0007502)1.76814896
130Abnormality of the salivary glands (HP:0010286)1.76149287
131Scapular winging (HP:0003691)1.76024342
132Spinal cord compression (HP:0002176)1.75285446
133Vascular calcification (HP:0004934)1.74030271
134Down-sloping shoulders (HP:0200021)1.73881928
135Sparse scalp hair (HP:0002209)1.73701752
136Tarsal synostosis (HP:0008368)1.73591920
137Glomerulonephritis (HP:0000099)1.72664162
138Spinal rigidity (HP:0003306)1.72632950
139Short nail (HP:0001799)1.72215409
140Blepharitis (HP:0000498)1.71881917
141Subcapsular cataract (HP:0000523)1.71872677
142Reduced subcutaneous adipose tissue (HP:0003758)1.70699460
143Ankyloglossia (HP:0010296)1.70194036
144Abnormality of the nasal septum (HP:0000419)1.69963184
145Overgrowth (HP:0001548)1.69411344
146Dry hair (HP:0011359)1.69130909
147Turricephaly (HP:0000262)1.69053114
148Hemorrhage of the eye (HP:0011885)1.67821810
149Abnormality of the middle phalanges of the toes (HP:0010183)1.67777813
150Dilatation of the ascending aorta (HP:0005111)1.67485069
151Sparse lateral eyebrow (HP:0005338)1.66886312
152Bowing of the arm (HP:0006488)1.65536994
153Bowed forearm bones (HP:0003956)1.65536994
154Bell-shaped thorax (HP:0001591)1.64443208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.57524957
2SIK13.85125849
3LATS13.39928867
4DDR23.27550830
5FER3.18272563
6MST43.02038098
7TRIB32.56834790
8FRK2.36366512
9STK392.35668190
10TTN2.25382650
11ERN12.16372913
12MYLK2.11568139
13EEF2K1.98788093
14RIPK11.96283557
15PTK61.95257360
16EPHB11.94048967
17CAMK1D1.88273063
18EPHB21.81792380
19LRRK21.77834174
20MST1R1.77180154
21PKN21.72382602
22PDGFRA1.67497158
23CDK121.62008763
24EPHA31.57932898
25MAP3K21.57199628
26WNK41.52558897
27SCYL21.50129010
28CAMK1G1.47948093
29TGFBR21.47810747
30PIK3CA1.47588924
31TRPM71.46849761
32PAK41.43832273
33MAP3K31.42098175
34MET1.40665674
35RPS6KB21.37273557
36MATK1.37249587
37PTK21.33497530
38PAK21.32858629
39ICK1.29907769
40LMTK21.25194703
41CDK61.21975471
42MAPKAPK31.19085888
43MAP3K61.17127468
44DMPK1.14683299
45STK101.13829081
46STK31.10872571
47NME21.08082872
48PDGFRB1.04377694
49TESK11.02641507
50BMX1.02269918
51IRAK30.97351444
52STK38L0.96438978
53DYRK1B0.95814907
54MAP2K20.95359246
55NME10.93549741
56FGFR40.93026937
57PDK20.91994691
58ERBB20.87612441
59PAK30.81906153
60SMG10.79672509
61FGFR30.78094038
62NEK90.75913853
63PDK40.75154436
64PDK30.75154436
65NUAK10.73456058
66RET0.73385296
67PRKD30.67100013
68MAP2K10.65843514
69PBK0.65698633
70TIE10.65293589
71MARK20.63353364
72FGFR10.62980239
73FGFR20.61236089
74MTOR0.57760679
75GSK3A0.56513531
76LATS20.55508397
77MAP3K130.55185756
78ROCK10.54027638
79BCKDK0.53549096
80NEK60.53397924
81ILK0.52735735
82CHUK0.52494737
83PHKG10.52367353
84PHKG20.52367353
85ARAF0.52045653
86PRKD20.50042995
87WNK10.50017136
88MAP3K70.47795753
89PRKCI0.47223198
90PRKD10.44606095
91MAP3K90.44328548
92PIM20.43981315
93MAPK150.42540972
94PIK3CG0.41929533
95MAPK70.39384788
96NTRK10.39068227
97BCR0.38966079
98CDK70.37584596
99NLK0.36441449
100RPS6KA20.36053970
101STK380.35722029
102ROCK20.34815562
103MAPKAPK20.34682950
104PRKG20.34638377
105OXSR10.34245365
106RPS6KA60.33100919
107CAMK2G0.32409187
108PTK2B0.32233063
109MAP3K10.32036099
110EGFR0.31401603
111INSRR0.30492270
112AKT20.30364089
113INSR0.29204319
114SRC0.29091346
115PRKCE0.28180908
116TGFBR10.27874610
117RPS6KA10.27622726
118HIPK20.27125190
119MAPK10.26605132
120PRKAA20.26146497
121IGF1R0.25813508
122SGK30.25197028
123MAPKAPK50.24691325
124AKT30.24575608
125TAOK10.23723187
126CDC42BPA0.22956220
127TYRO30.22065464
128STK240.20740023
129RPS6KC10.20515917
130RPS6KL10.20515917

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.45906964
2Fatty acid biosynthesis_Homo sapiens_hsa000613.28557022
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.11205943
4Adherens junction_Homo sapiens_hsa045202.86568224
5Complement and coagulation cascades_Homo sapiens_hsa046102.66640495
6Focal adhesion_Homo sapiens_hsa045102.42126093
7Retinol metabolism_Homo sapiens_hsa008302.34376927
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32500991
9Histidine metabolism_Homo sapiens_hsa003402.29292897
10Small cell lung cancer_Homo sapiens_hsa052222.26577378
11Tyrosine metabolism_Homo sapiens_hsa003502.19793578
12Hippo signaling pathway_Homo sapiens_hsa043902.15511004
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.15217355
14Tight junction_Homo sapiens_hsa045302.12462513
15Bladder cancer_Homo sapiens_hsa052192.07621334
16Arginine biosynthesis_Homo sapiens_hsa002202.05851657
17Caffeine metabolism_Homo sapiens_hsa002322.03256766
18Proteoglycans in cancer_Homo sapiens_hsa052051.95737267
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.92531656
20Protein digestion and absorption_Homo sapiens_hsa049741.89950215
21Amoebiasis_Homo sapiens_hsa051461.83366479
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.81453433
23TGF-beta signaling pathway_Homo sapiens_hsa043501.77685645
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71080545
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.69275720
26Basal cell carcinoma_Homo sapiens_hsa052171.68971542
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.61629180
28Bile secretion_Homo sapiens_hsa049761.60669564
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50892336
30Endometrial cancer_Homo sapiens_hsa052131.45477080
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.44372298
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44126141
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42442640
34Thyroid cancer_Homo sapiens_hsa052161.41551427
35Sulfur metabolism_Homo sapiens_hsa009201.40182502
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35710677
37Pancreatic cancer_Homo sapiens_hsa052121.34890742
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34860026
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31865275
40Chronic myeloid leukemia_Homo sapiens_hsa052201.29886785
41Toxoplasmosis_Homo sapiens_hsa051451.29810710
42Fatty acid metabolism_Homo sapiens_hsa012121.23488968
43Dilated cardiomyopathy_Homo sapiens_hsa054141.22626731
44MicroRNAs in cancer_Homo sapiens_hsa052061.20023098
45Notch signaling pathway_Homo sapiens_hsa043301.19227303
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18723412
47Fatty acid degradation_Homo sapiens_hsa000711.18327791
48Starch and sucrose metabolism_Homo sapiens_hsa005001.17674305
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17557661
50Arachidonic acid metabolism_Homo sapiens_hsa005901.17365198
51Circadian rhythm_Homo sapiens_hsa047101.14868431
52Prostate cancer_Homo sapiens_hsa052151.13123954
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09590156
54Pathways in cancer_Homo sapiens_hsa052001.08115679
55Melanoma_Homo sapiens_hsa052181.05324183
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05035562
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03164682
58PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02895676
59Dorso-ventral axis formation_Homo sapiens_hsa043201.02642215
60PPAR signaling pathway_Homo sapiens_hsa033201.01668446
61beta-Alanine metabolism_Homo sapiens_hsa004101.00151874
62ABC transporters_Homo sapiens_hsa020100.99722562
63Insulin resistance_Homo sapiens_hsa049310.97110377
64Prolactin signaling pathway_Homo sapiens_hsa049170.94110254
65Linoleic acid metabolism_Homo sapiens_hsa005910.92970920
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.90947861
67Prion diseases_Homo sapiens_hsa050200.88219133
68Propanoate metabolism_Homo sapiens_hsa006400.85444310
69Viral myocarditis_Homo sapiens_hsa054160.83291687
70Mineral absorption_Homo sapiens_hsa049780.82898848
71Renal cell carcinoma_Homo sapiens_hsa052110.82460327
72Pancreatic secretion_Homo sapiens_hsa049720.82004859
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.80687135
74Platelet activation_Homo sapiens_hsa046110.80649328
75Wnt signaling pathway_Homo sapiens_hsa043100.79691529
76Rap1 signaling pathway_Homo sapiens_hsa040150.78130012
77AMPK signaling pathway_Homo sapiens_hsa041520.77131560
78Colorectal cancer_Homo sapiens_hsa052100.76843750
79Lysine degradation_Homo sapiens_hsa003100.76449076
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76087984
81Hedgehog signaling pathway_Homo sapiens_hsa043400.75974964
82Melanogenesis_Homo sapiens_hsa049160.75741912
83Vibrio cholerae infection_Homo sapiens_hsa051100.75684611
84Acute myeloid leukemia_Homo sapiens_hsa052210.74825446
85Glucagon signaling pathway_Homo sapiens_hsa049220.73931790
86Fructose and mannose metabolism_Homo sapiens_hsa000510.73523501
87ErbB signaling pathway_Homo sapiens_hsa040120.67787761
88Arginine and proline metabolism_Homo sapiens_hsa003300.66528727
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66392209
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64657015
91Axon guidance_Homo sapiens_hsa043600.63501605
92Hepatitis C_Homo sapiens_hsa051600.63206363
93Renin-angiotensin system_Homo sapiens_hsa046140.62062693
94HIF-1 signaling pathway_Homo sapiens_hsa040660.61813660
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61520215
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61357716
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59975426
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59805593
99Tryptophan metabolism_Homo sapiens_hsa003800.59268735
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58982397
101Non-small cell lung cancer_Homo sapiens_hsa052230.58296890
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.57871374
103Glioma_Homo sapiens_hsa052140.57507099
104VEGF signaling pathway_Homo sapiens_hsa043700.56989632
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56719080
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54632091
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54308210
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54263737
109Phenylalanine metabolism_Homo sapiens_hsa003600.53741633
110Biosynthesis of amino acids_Homo sapiens_hsa012300.52484872
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52346374
112Gastric acid secretion_Homo sapiens_hsa049710.50956008
113Insulin signaling pathway_Homo sapiens_hsa049100.50692309
114Fat digestion and absorption_Homo sapiens_hsa049750.49629238
115Chemical carcinogenesis_Homo sapiens_hsa052040.49507424
116Endocytosis_Homo sapiens_hsa041440.48783568
117Thyroid hormone synthesis_Homo sapiens_hsa049180.48667938
118mTOR signaling pathway_Homo sapiens_hsa041500.48073149
119N-Glycan biosynthesis_Homo sapiens_hsa005100.47069965
120Inositol phosphate metabolism_Homo sapiens_hsa005620.46516849
121Salivary secretion_Homo sapiens_hsa049700.45946149
122Estrogen signaling pathway_Homo sapiens_hsa049150.45502735
123Renin secretion_Homo sapiens_hsa049240.45468883
124Vitamin B6 metabolism_Homo sapiens_hsa007500.45112164
125HTLV-I infection_Homo sapiens_hsa051660.44734972
126Pyruvate metabolism_Homo sapiens_hsa006200.44466769
127TNF signaling pathway_Homo sapiens_hsa046680.42987250
128FoxO signaling pathway_Homo sapiens_hsa040680.41197004
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40049251
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40024782
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39393253
132Malaria_Homo sapiens_hsa051440.39126863
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39020002
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38570012
135Choline metabolism in cancer_Homo sapiens_hsa052310.38524052
136Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38037799
137Sphingolipid metabolism_Homo sapiens_hsa006000.37746617
138Glycerolipid metabolism_Homo sapiens_hsa005610.37622584
139Ovarian steroidogenesis_Homo sapiens_hsa049130.37614148

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