ANO10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.95570421
2COPI coating of Golgi vesicle (GO:0048205)4.95570421
3cell adhesion mediated by integrin (GO:0033627)4.19779632
4regulation of sequestering of triglyceride (GO:0010889)3.96345651
5low-density lipoprotein particle clearance (GO:0034383)3.96245283
6type B pancreatic cell proliferation (GO:0044342)3.82918837
7sequestering of extracellular ligand from receptor (GO:0035581)3.79095471
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.77164214
9negative regulation of potassium ion transmembrane transport (GO:1901380)3.64416833
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55282764
11COPII vesicle coating (GO:0048208)3.54016733
12UDP-N-acetylglucosamine metabolic process (GO:0006047)3.38674259
13barbed-end actin filament capping (GO:0051016)3.37913147
14protein maturation by protein folding (GO:0022417)3.24666531
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21567619
16protein retention in ER lumen (GO:0006621)3.21404865
17angiotensin maturation (GO:0002003)3.19608302
18cellular response to vitamin D (GO:0071305)3.17811932
19long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.17698465
20creatine metabolic process (GO:0006600)3.16898845
21sarcomere organization (GO:0045214)3.14738226
22fatty-acyl-CoA biosynthetic process (GO:0046949)3.13430907
23nucleotide-sugar biosynthetic process (GO:0009226)3.12329822
24long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.12199751
25desmosome organization (GO:0002934)3.11761458
26regulation of cholesterol esterification (GO:0010872)3.11609416
27carnitine shuttle (GO:0006853)3.10021681
28proline biosynthetic process (GO:0006561)3.08709001
29thioester biosynthetic process (GO:0035384)3.08434520
30acyl-CoA biosynthetic process (GO:0071616)3.08434520
31fatty-acyl-CoA metabolic process (GO:0035337)3.07073081
32heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.06144261
33ventricular cardiac muscle cell action potential (GO:0086005)3.04187947
34plasma membrane repair (GO:0001778)2.99752679
35negative regulation of protein localization to cell surface (GO:2000009)2.99023509
36glomerular filtration (GO:0003094)2.98941778
37substrate-dependent cell migration (GO:0006929)2.98217296
38carnitine transmembrane transport (GO:1902603)2.97891531
39fatty acid transmembrane transport (GO:1902001)2.96844401
40vesicle coating (GO:0006901)2.92955662
41renal filtration (GO:0097205)2.88199913
42lipid particle organization (GO:0034389)2.86665519
43protein localization to endosome (GO:0036010)2.86533877
44carnitine transport (GO:0015879)2.86082541
45amino-acid betaine transport (GO:0015838)2.86082541
46regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.85956721
47hemidesmosome assembly (GO:0031581)2.84267140
48fatty acid elongation (GO:0030497)2.84051978
49paraxial mesoderm development (GO:0048339)2.81437939
50regulation of integrin-mediated signaling pathway (GO:2001044)2.80233186
51blood vessel maturation (GO:0001955)2.78152177
52virion attachment to host cell (GO:0019062)2.77974313
53adhesion of symbiont to host cell (GO:0044650)2.77974313
544-hydroxyproline metabolic process (GO:0019471)2.77568099
55tricarboxylic acid cycle (GO:0006099)2.76485646
56basement membrane organization (GO:0071711)2.75927807
57positive regulation of fatty acid beta-oxidation (GO:0032000)2.75494684
58L-serine transport (GO:0015825)2.75193380
59endothelial cell proliferation (GO:0001935)2.74129540
60collagen fibril organization (GO:0030199)2.73856160
61fatty acid beta-oxidation (GO:0006635)2.72062887
62skin morphogenesis (GO:0043589)2.71036292
63bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70884815
64positive regulation of fatty acid oxidation (GO:0046321)2.70571587
65neuron projection extension involved in neuron projection guidance (GO:1902284)2.69975051
66axon extension involved in axon guidance (GO:0048846)2.69975051
67bone trabecula formation (GO:0060346)2.69815047
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.69763831
69positive regulation of Rho protein signal transduction (GO:0035025)2.69713070
70myelin maintenance (GO:0043217)2.68894436
71L-ascorbic acid metabolic process (GO:0019852)2.67825209
72negative regulation of smooth muscle cell migration (GO:0014912)2.67765062
73phospholipid efflux (GO:0033700)2.67118394
74growth hormone receptor signaling pathway (GO:0060396)2.66725441
75sphingolipid catabolic process (GO:0030149)2.64735536
76intestinal absorption (GO:0050892)2.64653171
77cardiac myofibril assembly (GO:0055003)2.64629517
78protein targeting to plasma membrane (GO:0072661)2.64005404
79protein hydroxylation (GO:0018126)2.62544006
80cell migration involved in sprouting angiogenesis (GO:0002042)2.61987115
81plasma lipoprotein particle assembly (GO:0034377)2.61441999
82epithelial cell-cell adhesion (GO:0090136)2.61263441
83triglyceride biosynthetic process (GO:0019432)2.61089822
84regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60813150
85substrate adhesion-dependent cell spreading (GO:0034446)2.60164757
86extracellular fibril organization (GO:0043206)2.59237585
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57798202
88endocardial cushion development (GO:0003197)2.57096832
89hyaluronan catabolic process (GO:0030214)2.56065311
90adhesion of symbiont to host (GO:0044406)2.56038670
91negative regulation of keratinocyte proliferation (GO:0010839)2.54319356
92regulation of fatty acid oxidation (GO:0046320)2.54116411
93acylglycerol biosynthetic process (GO:0046463)2.52908811
94neutral lipid biosynthetic process (GO:0046460)2.52908811
95glycosphingolipid catabolic process (GO:0046479)2.52748736
96protein heterotrimerization (GO:0070208)2.52294521
97membrane raft organization (GO:0031579)2.52157175
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.51767365
99membrane lipid catabolic process (GO:0046466)2.49970560
100cholesterol biosynthetic process (GO:0006695)2.49873031
101negative regulation of chondrocyte differentiation (GO:0032331)2.49517809
102apoptotic cell clearance (GO:0043277)2.49491240
103wound healing, spreading of epidermal cells (GO:0035313)2.47843305
104central nervous system myelination (GO:0022010)2.46737056
105axon ensheathment in central nervous system (GO:0032291)2.46737056
106positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.45575574
107alpha-linolenic acid metabolic process (GO:0036109)2.45198447
108negative chemotaxis (GO:0050919)2.44087259
109protein-lipid complex assembly (GO:0065005)2.42936357
110keratan sulfate catabolic process (GO:0042340)2.42114944
111actin filament depolymerization (GO:0030042)2.41779481
112sphingomyelin metabolic process (GO:0006684)2.41270349
113lymphangiogenesis (GO:0001946)2.40963308
114cardiolipin metabolic process (GO:0032048)2.40891337
115sterol biosynthetic process (GO:0016126)2.40625790
116regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.39116174
117glycolipid catabolic process (GO:0019377)2.38028006
118fatty acid catabolic process (GO:0009062)2.37020150
119regulation of gastrulation (GO:0010470)2.36721871
120brown fat cell differentiation (GO:0050873)2.36686786
121regulation of lipoprotein metabolic process (GO:0050746)2.36593173
122regulation of tight junction assembly (GO:2000810)2.36360466
123serine transport (GO:0032329)2.35601330
124high-density lipoprotein particle remodeling (GO:0034375)2.34941018
125cellular response to growth hormone stimulus (GO:0071378)2.34572529
126NADPH regeneration (GO:0006740)2.34534998
127extracellular matrix disassembly (GO:0022617)2.34208229
128cellular copper ion homeostasis (GO:0006878)2.32922730
129fatty acid oxidation (GO:0019395)2.32701674
130triglyceride catabolic process (GO:0019433)2.32543853
131fibril organization (GO:0097435)2.30046271
132regulation of cytokine secretion involved in immune response (GO:0002739)2.29830507
133lipid oxidation (GO:0034440)2.29741944
134endodermal cell differentiation (GO:0035987)2.28492649
135fusion of sperm to egg plasma membrane (GO:0007342)2.28266005
136regulation of transforming growth factor beta1 production (GO:0032908)2.28241199
137cellular response to vitamin (GO:0071295)2.28147829
138myofibril assembly (GO:0030239)2.28079568
139actin-myosin filament sliding (GO:0033275)2.27997944
140muscle filament sliding (GO:0030049)2.27997944
141very-low-density lipoprotein particle assembly (GO:0034379)2.27942663
142acetyl-CoA metabolic process (GO:0006084)2.27848887
143vascular endothelial growth factor signaling pathway (GO:0038084)2.27279732
144negative regulation of protein localization to plasma membrane (GO:1903077)2.26872755
145NADH metabolic process (GO:0006734)2.26593425
146extracellular matrix assembly (GO:0085029)2.26434642
147oligosaccharide catabolic process (GO:0009313)2.26275729
148regulation of fatty acid beta-oxidation (GO:0031998)2.26163987
149extracellular regulation of signal transduction (GO:1900115)2.25417135
150glycerol metabolic process (GO:0006071)2.21872014
151collagen metabolic process (GO:0032963)2.20417132
152positive regulation of glycogen biosynthetic process (GO:0045725)2.19908472
153actomyosin structure organization (GO:0031032)2.19039599
154regulation of p38MAPK cascade (GO:1900744)2.18363698
155multicellular organismal macromolecule metabolic process (GO:0044259)2.17970314
156peptidyl-proline hydroxylation (GO:0019511)2.16441892
157collagen catabolic process (GO:0030574)2.16174114
158regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.15039874
159quaternary ammonium group transport (GO:0015697)2.14973386
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.14734996
161actin-mediated cell contraction (GO:0070252)2.13993492
162positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.12612421
163multicellular organismal metabolic process (GO:0044236)2.12450333
164regulation of chemokine-mediated signaling pathway (GO:0070099)2.11987813
165thioester metabolic process (GO:0035383)2.11742529
166acyl-CoA metabolic process (GO:0006637)2.11742529
167long-chain fatty acid biosynthetic process (GO:0042759)2.10803328
168white fat cell differentiation (GO:0050872)2.09794114
169multicellular organismal catabolic process (GO:0044243)2.08960322
170positive regulation of fatty acid metabolic process (GO:0045923)2.08715687
171stress fiber assembly (GO:0043149)2.08409590
172regulation of skeletal muscle contraction (GO:0014819)2.06989047
173endocytic recycling (GO:0032456)2.06286478
174chondrocyte proliferation (GO:0035988)2.05482369
175regulation of triglyceride catabolic process (GO:0010896)2.05335396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72552345
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.45267443
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.27140518
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74355514
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.47282891
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39738353
7BRD4_25478319_ChIP-Seq_HGPS_Human2.38540488
8CLOCK_20551151_ChIP-Seq_293T_Human2.36174148
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23098895
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.22323238
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.19385162
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18592660
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.12494508
14TCF3_18692474_ChIP-Seq_MEFs_Mouse1.96465909
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89912240
16SALL4_18804426_ChIP-ChIP_XEN_Mouse1.80049623
17EOMES_21245162_ChIP-Seq_HESCs_Human1.76770758
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.76721037
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75825035
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.75234518
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74070866
22CJUN_26792858_Chip-Seq_BT549_Human1.67081154
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66030115
24AR_21909140_ChIP-Seq_LNCAP_Human1.65107515
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62356389
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62145657
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.59483671
28TBX20_22080862_ChIP-Seq_HEART_Mouse1.59483671
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.51640196
30SOX17_20123909_ChIP-Seq_XEN_Mouse1.50915737
31EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.49920268
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.49566022
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49506852
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.47677927
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47283502
36GATA4_25053715_ChIP-Seq_YYC3_Human1.46869701
37CDX2_20551321_ChIP-Seq_CACO-2_Human1.46131305
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.42774411
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41936012
40* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40037907
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.33580502
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32761896
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32761896
44ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32428386
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32025160
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28970390
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27279585
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.26835531
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25549978
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24707909
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.24305979
52AR_21572438_ChIP-Seq_LNCaP_Human1.23917002
53* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23182977
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22434464
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22051548
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21791455
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.21634536
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20445559
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20445559
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18447243
61SOX2_20726797_ChIP-Seq_SW620_Human1.18254589
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16978450
63PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16465182
64TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14204958
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13625523
66DROSHA_22980978_ChIP-Seq_HELA_Human1.13309076
67TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13202348
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.12448752
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10887264
70SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10721268
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.09351735
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09219061
73GBX2_23144817_ChIP-Seq_PC3_Human1.08926277
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07271175
75NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06808112
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06619732
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06496814
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05805051
79ELK1_19687146_ChIP-ChIP_HELA_Human1.05419709
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05272621
81GATA6_25053715_ChIP-Seq_YYC3_Human1.04526435
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04502559
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04439353
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04278516
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03814306
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.03557449
87JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03135660
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02719324
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02632329
90TP53_16413492_ChIP-PET_HCT116_Human1.01897622
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01744196
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.01590785
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01483410
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01322164
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00819351
96AHR_22903824_ChIP-Seq_MCF-7_Human0.99921414
97TFEB_21752829_ChIP-Seq_HELA_Human0.99394594
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99250926
99* CDX2_22108803_ChIP-Seq_LS180_Human0.99064359
100GABP_17652178_ChIP-ChIP_JURKAT_Human0.99054486
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98563290
102PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98075077
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96916596
104ZNF263_19887448_ChIP-Seq_K562_Human0.95584308
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95064330
106SMAD_19615063_ChIP-ChIP_OVARY_Human0.94369506
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94283185
108KLF5_25053715_ChIP-Seq_YYC3_Human0.94074557
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92972858
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92487912
111JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92412809
112PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92221170
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92218805
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92145906
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91925649
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.91632463
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91421567
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91406293
119TP63_23658742_ChIP-Seq_EP156T_Human0.91365050
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90852585
121NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90801132
122KDM2B_26808549_Chip-Seq_K562_Human0.90726560
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90627080
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90167805
125* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89850853
126KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89744218
127TP63_22573176_ChIP-Seq_HFKS_Human0.89560928
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89033333
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88648121
130LXR_22292898_ChIP-Seq_THP-1_Human0.88622711
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88530005
132Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88256659
133SA1_22415368_ChIP-Seq_MEFs_Mouse0.88145720
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88000102
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.87888047
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87841377
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87226187
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87122326
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87122326
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87122326
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.86981785
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86850732
143P300_19829295_ChIP-Seq_ESCs_Human0.86791118
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.86557196
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85862835
146VDR_24787735_ChIP-Seq_THP-1_Human0.85700398
147SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85281311
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85281311
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84708638
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84252486
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.82345194
152TP53_18474530_ChIP-ChIP_U2OS_Human0.82189031
153RXR_22108803_ChIP-Seq_LS180_Human0.81987180
154SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81390426
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.80956343
156ISL1_27105846_Chip-Seq_CPCs_Mouse0.80606904
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.79795774
158ELK3_25401928_ChIP-Seq_HUVEC_Human0.78945656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.90091186
2MP0002837_dystrophic_cardiac_calcinosis4.08782288
3MP0003941_abnormal_skin_development3.73769380
4MP0005670_abnormal_white_adipose3.45133177
5MP0005275_abnormal_skin_tensile3.44810815
6MP0000751_myopathy3.16044661
7MP0010030_abnormal_orbit_morphology2.83457918
8MP0002254_reproductive_system_inflammat2.66531660
9MP0004130_abnormal_muscle_cell2.60796473
10MP0005257_abnormal_intraocular_pressure2.57923298
11MP0005666_abnormal_adipose_tissue2.51340752
12MP0004272_abnormal_basement_membrane2.48603849
13MP0004084_abnormal_cardiac_muscle2.46797424
14MP0003705_abnormal_hypodermis_morpholog2.37358396
15MP0004185_abnormal_adipocyte_glucose2.28711280
16MP0005360_urolithiasis2.26501324
17MP0003279_aneurysm2.25116254
18MP0005623_abnormal_meninges_morphology2.24272833
19MP0004036_abnormal_muscle_relaxation2.23426083
20MP0001958_emphysema2.11661888
21MP0003646_muscle_fatigue2.10617294
22MP0010368_abnormal_lymphatic_system2.03879146
23MP0000749_muscle_degeneration1.95900924
24MP0005375_adipose_tissue_phenotype1.91164552
25MP0005503_abnormal_tendon_morphology1.85749470
26MP0010352_gastrointestinal_tract_polyps1.84039001
27MP0000013_abnormal_adipose_tissue1.82396224
28MP0001542_abnormal_bone_strength1.79062710
29MP0004087_abnormal_muscle_fiber1.75284670
30MP0002972_abnormal_cardiac_muscle1.72594596
31MP0009384_cardiac_valve_regurgitation1.72207864
32MP0003950_abnormal_plasma_membrane1.65362395
33MP0000750_abnormal_muscle_regeneration1.65263951
34MP0004215_abnormal_myocardial_fiber1.64133259
35MP0005620_abnormal_muscle_contractility1.63987032
36MP0003329_amyloid_beta_deposits1.62258176
37MP0008775_abnormal_heart_ventricle1.57158550
38MP0003566_abnormal_cell_adhesion1.56532950
39MP0004147_increased_porphyrin_level1.52815782
40MP0003718_maternal_effect1.51955391
41MP0004233_abnormal_muscle_weight1.51654881
42MP0000767_abnormal_smooth_muscle1.51205201
43MP0000747_muscle_weakness1.51201651
44MP0004858_abnormal_nervous_system1.50465029
45MP0005330_cardiomyopathy1.47337522
46MP0010234_abnormal_vibrissa_follicle1.44457293
47MP0006138_congestive_heart_failure1.41146217
48MP0005408_hypopigmentation1.39620302
49MP0000759_abnormal_skeletal_muscle1.38388884
50MP0004264_abnormal_extraembryonic_tissu1.36124341
51MP0005385_cardiovascular_system_phenoty1.31721187
52MP0001544_abnormal_cardiovascular_syste1.31721187
53MP0006054_spinal_hemorrhage1.30921675
54MP0005085_abnormal_gallbladder_physiolo1.30425571
55MP0002796_impaired_skin_barrier1.30327221
56MP0000003_abnormal_adipose_tissue1.30011653
57MP0001666_abnormal_nutrient_absorption1.27758363
58MP0003186_abnormal_redox_activity1.27702442
59MP0002269_muscular_atrophy1.24890214
60MP0001243_abnormal_dermal_layer1.24060149
61MP0002971_abnormal_brown_adipose1.24029988
62MP0005595_abnormal_vascular_smooth1.23982311
63MP0000920_abnormal_myelination1.20150320
64MP0004019_abnormal_vitamin_homeostasis1.19170131
65MP0010386_abnormal_urinary_bladder1.17750223
66MP0002060_abnormal_skin_morphology1.16548008
67MP0002108_abnormal_muscle_morphology1.15656745
68MP0010630_abnormal_cardiac_muscle1.15624872
69MP0000343_altered_response_to1.15336479
70MP0002938_white_spotting1.13764019
71MP0005365_abnormal_bile_salt1.13718589
72MP0003690_abnormal_glial_cell1.10232956
73MP0002106_abnormal_muscle_physiology1.09147806
74MP0002933_joint_inflammation1.07778262
75MP0001881_abnormal_mammary_gland1.06741945
76MP0002295_abnormal_pulmonary_circulatio1.06423539
77MP0005410_abnormal_fertilization1.06403996
78MP0008004_abnormal_stomach_pH1.04273978
79MP0001299_abnormal_eye_distance/1.03744432
80MP0003868_abnormal_feces_composition1.03616112
81MP0000604_amyloidosis1.02925623
82MP0004134_abnormal_chest_morphology1.02579088
83MP0008260_abnormal_autophagy1.02519338
84MP0005197_abnormal_uvea_morphology1.01996846
85MP0001849_ear_inflammation1.01849449
86MP0005369_muscle_phenotype1.01493253
87MP0003755_abnormal_palate_morphology1.00970807
88MP0003045_fibrosis1.00701089
89MP0004484_altered_response_of1.00146183
90MP0000579_abnormal_nail_morphology0.99655671
91MP0003385_abnormal_body_wall0.96716333
92MP0008932_abnormal_embryonic_tissue0.95026729
93MP0000762_abnormal_tongue_morphology0.94857558
94MP0005409_darkened_coat_color0.94003793
95MP0002118_abnormal_lipid_homeostasis0.93716483
96MP0000428_abnormal_craniofacial_morphol0.93141642
97MP0003091_abnormal_cell_migration0.92766271
98MP0005508_abnormal_skeleton_morphology0.90914384
99MP0000467_abnormal_esophagus_morphology0.90126606
100MP0003937_abnormal_limbs/digits/tail_de0.89470383
101MP0003137_abnormal_impulse_conducting0.88797733
102MP0004145_abnormal_muscle_electrophysio0.86534036
103MP0000733_abnormal_muscle_development0.86219648
104MP0003828_pulmonary_edema0.86121907
105MP0009840_abnormal_foam_cell0.85446420
106MP0002896_abnormal_bone_mineralization0.84966889
107MP0005023_abnormal_wound_healing0.84824854
108MP0002139_abnormal_hepatobiliary_system0.84497836
109MP0002909_abnormal_adrenal_gland0.84467590
110MP0005395_other_phenotype0.84134543
111MP0010329_abnormal_lipoprotein_level0.84013976
112MP0003959_abnormal_lean_body0.82825894
113MP0003300_gastrointestinal_ulcer0.80842642
114MP0000537_abnormal_urethra_morphology0.80645279
115MP0000462_abnormal_digestive_system0.80446586
116MP0003890_abnormal_embryonic-extraembry0.80182817
117MP0003183_abnormal_peptide_metabolism0.79937825
118MP0000534_abnormal_ureter_morphology0.79563778
119MP0000538_abnormal_urinary_bladder0.79156414
120MP0003634_abnormal_glial_cell0.78955356
121MP0001614_abnormal_blood_vessel0.77892490
122MP0002697_abnormal_eye_size0.77479042
123MP0002282_abnormal_trachea_morphology0.77171059
124MP0004085_abnormal_heartbeat0.76624225
125MP0009780_abnormal_chondrocyte_physiolo0.76180307
126MP0009115_abnormal_fat_cell0.76156370
127MP0005058_abnormal_lysosome_morphology0.75978043
128MP0009250_abnormal_appendicular_skeleto0.75216644
129MP0010678_abnormal_skin_adnexa0.74689043
130MP0003191_abnormal_cellular_cholesterol0.73389817
131MP0005165_increased_susceptibility_to0.73094801
132MP0001879_abnormal_lymphatic_vessel0.72098665
133MP0000230_abnormal_systemic_arterial0.71924014
134MP0001533_abnormal_skeleton_physiology0.71845855
135MP0005334_abnormal_fat_pad0.71471251
136MP0000647_abnormal_sebaceous_gland0.70159858
137MP0002233_abnormal_nose_morphology0.70013232
138MP0000427_abnormal_hair_cycle0.69436834
139MP0002111_abnormal_tail_morphology0.69404065
140MP0004957_abnormal_blastocyst_morpholog0.69379292
141MP0005501_abnormal_skin_physiology0.68791693
142MP0000163_abnormal_cartilage_morphology0.68725353
143MP0003221_abnormal_cardiomyocyte_apopto0.68716324
144MP0005164_abnormal_response_to0.68584056
145MP0000432_abnormal_head_morphology0.67975494
146MP0002090_abnormal_vision0.67553555
147MP0005248_abnormal_Harderian_gland0.66317481
148MP0003283_abnormal_digestive_organ0.65506177
149MP0003453_abnormal_keratinocyte_physiol0.65243366
150MP0002084_abnormal_developmental_patter0.64075456
151MP0009379_abnormal_foot_pigmentation0.63671089
152MP0001216_abnormal_epidermal_layer0.62426556
153MP0001915_intracranial_hemorrhage0.60811593
154MP0003448_altered_tumor_morphology0.59828104
155MP0000358_abnormal_cell_content/0.59420105
156MP0000516_abnormal_urinary_system0.59123182
157MP0005367_renal/urinary_system_phenotyp0.59123182
158MP0002085_abnormal_embryonic_tissue0.58462256

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.27262255
2Muscle fiber splitting (HP:0003555)4.26359061
3Hyporeflexia of lower limbs (HP:0002600)4.26109658
4Right ventricular cardiomyopathy (HP:0011663)4.16252942
5Difficulty running (HP:0009046)3.88459110
6Protrusio acetabuli (HP:0003179)3.75881326
7Cervical subluxation (HP:0003308)3.64711356
8Ventricular tachycardia (HP:0004756)3.56088028
9Broad metatarsal (HP:0001783)3.43601236
10Increased connective tissue (HP:0009025)3.36821434
11Increased variability in muscle fiber diameter (HP:0003557)3.07107925
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06670586
13Sudden death (HP:0001699)3.05836370
14Aortic dissection (HP:0002647)3.04400680
15Neurofibrillary tangles (HP:0002185)2.98957589
16Exercise-induced muscle cramps (HP:0003710)2.97891685
17Genu recurvatum (HP:0002816)2.97118872
18Slender build (HP:0001533)2.97004721
19Exercise-induced myalgia (HP:0003738)2.96515246
20Intrahepatic cholestasis (HP:0001406)2.96045391
21Ileus (HP:0002595)2.95987509
22Type 1 muscle fiber predominance (HP:0003803)2.92231988
23Calf muscle hypertrophy (HP:0008981)2.80532031
24Muscle hypertrophy of the lower extremities (HP:0008968)2.78963679
25Ankle contracture (HP:0006466)2.76891034
26Myoglobinuria (HP:0002913)2.76682455
27Cardiovascular calcification (HP:0011915)2.72442114
28Abnormal delivery (HP:0001787)2.71933929
29Lipoatrophy (HP:0100578)2.66654737
30Abnormality of skeletal muscle fiber size (HP:0012084)2.64686109
31Abnormality of the calf musculature (HP:0001430)2.60440212
32Hypoplastic ischia (HP:0003175)2.59032124
33Spinal rigidity (HP:0003306)2.58266463
34Stridor (HP:0010307)2.58019785
35Aortic aneurysm (HP:0004942)2.57139514
36Arterial tortuosity (HP:0005116)2.55374307
37Vascular tortuosity (HP:0004948)2.54644929
38Hand muscle atrophy (HP:0009130)2.54340976
39Cerebral inclusion bodies (HP:0100314)2.50885243
40Vertebral compression fractures (HP:0002953)2.44638898
41EMG: myopathic abnormalities (HP:0003458)2.41119049
42Asymmetric septal hypertrophy (HP:0001670)2.39130164
43Atrial fibrillation (HP:0005110)2.38675804
44Cerebral aneurysm (HP:0004944)2.33251327
45Abnormality of the ischium (HP:0003174)2.32495177
46Abnormality of the acetabulum (HP:0003170)2.31890420
47Difficulty climbing stairs (HP:0003551)2.28688942
48Hypoalphalipoproteinemia (HP:0003233)2.28167974
49Shallow orbits (HP:0000586)2.28160649
50Scapular winging (HP:0003691)2.27982781
51Coronal craniosynostosis (HP:0004440)2.27732076
52Peritonitis (HP:0002586)2.27515520
53Primary atrial arrhythmia (HP:0001692)2.24771429
54Pheochromocytoma (HP:0002666)2.23043255
55Atrophic scars (HP:0001075)2.22649275
56Soft skin (HP:0000977)2.22179365
57Vacuolated lymphocytes (HP:0001922)2.21725936
58Vascular calcification (HP:0004934)2.19099605
59Cortical dysplasia (HP:0002539)2.15789494
60Short nail (HP:0001799)2.15615100
61Hypolipoproteinemia (HP:0010981)2.14339366
62Flat acetabular roof (HP:0003180)2.12870532
63Breech presentation (HP:0001623)2.12131051
64Mildly elevated creatine phosphokinase (HP:0008180)2.12089253
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12076716
66Muscle stiffness (HP:0003552)2.11941810
67Palpitations (HP:0001962)2.11423773
68Nonimmune hydrops fetalis (HP:0001790)2.10364612
69Natal tooth (HP:0000695)2.10115073
70Cupped ribs (HP:0000887)2.09901136
71Supraventricular arrhythmia (HP:0005115)2.09201411
72Rhabdomyolysis (HP:0003201)2.07598731
73Abnormality of carpal bone ossification (HP:0006257)2.07355688
74Neonatal short-limb short stature (HP:0008921)2.07038015
75Bladder diverticulum (HP:0000015)2.05850657
76Supraventricular tachycardia (HP:0004755)2.05292585
77Follicular hyperkeratosis (HP:0007502)2.04748613
78Acanthosis nigricans (HP:0000956)2.04266517
79Spondylolisthesis (HP:0003302)2.04141480
80Ventricular arrhythmia (HP:0004308)2.03525150
81Joint laxity (HP:0001388)2.03448832
82Gowers sign (HP:0003391)2.02869891
83Syncope (HP:0001279)2.02447461
84Abnormality of dentin (HP:0010299)2.02104817
85Ventricular fibrillation (HP:0001663)2.00698023
86Bell-shaped thorax (HP:0001591)2.00050025
87Prolonged QT interval (HP:0001657)1.99938590
88Hypoplasia of the iris (HP:0007676)1.99286487
89Delayed gross motor development (HP:0002194)1.99116870
90Wormian bones (HP:0002645)1.99077394
91Redundant skin (HP:0001582)1.98234795
92Fat malabsorption (HP:0002630)1.97973229
93Limb-girdle muscle weakness (HP:0003325)1.97536956
94Bifid tongue (HP:0010297)1.97405032
95Oligomenorrhea (HP:0000876)1.97295757
96Hyperextensible skin (HP:0000974)1.94626041
97Protuberant abdomen (HP:0001538)1.92479963
98Foot dorsiflexor weakness (HP:0009027)1.92194831
99Increased serum pyruvate (HP:0003542)1.91612663
100Malnutrition (HP:0004395)1.90819543
101Infantile muscular hypotonia (HP:0008947)1.90506035
102Wrist flexion contracture (HP:0001239)1.90226287
103Abnormality of fatty-acid metabolism (HP:0004359)1.90193948
104Neuroendocrine neoplasm (HP:0100634)1.90179024
105Bowel diverticulosis (HP:0005222)1.89840036
106Fragile skin (HP:0001030)1.89828931
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89666337
108Osteolytic defects of the phalanges of the hand (HP:0009771)1.88065854
109Osteolytic defects of the hand bones (HP:0009699)1.88065854
110Dilated cardiomyopathy (HP:0001644)1.87567175
111Cholecystitis (HP:0001082)1.87543346
112Abnormal gallbladder physiology (HP:0012438)1.87543346
113Microglossia (HP:0000171)1.87164825
114Myotonia (HP:0002486)1.86958056
115Visceral angiomatosis (HP:0100761)1.84176755
116Elbow flexion contracture (HP:0002987)1.83525780
117Cerebral hemorrhage (HP:0001342)1.82836168
118Abnormal umbilical cord blood vessels (HP:0011403)1.82044495
119Single umbilical artery (HP:0001195)1.82044495
120Abnormality of the fetal cardiovascular system (HP:0010948)1.82044495
121Bundle branch block (HP:0011710)1.81983870
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81938703
123Aneurysm (HP:0002617)1.81819735
124Abnormality of the umbilical cord (HP:0010881)1.81559698
125Lymphangioma (HP:0100764)1.80215236
126Proximal tubulopathy (HP:0000114)1.79690492
127Abnormality of glycolysis (HP:0004366)1.78533801
128Abnormality of liposaccharide metabolism (HP:0010968)1.75929128
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.75929128
130Abnormality of glycolipid metabolism (HP:0010969)1.75929128
131Limb-girdle muscle atrophy (HP:0003797)1.75061534
132Hypoventilation (HP:0002791)1.73972492
133Mitral valve prolapse (HP:0001634)1.73868884
134Blue sclerae (HP:0000592)1.73549284
135Dilatation of the ascending aorta (HP:0005111)1.73482277
136Hamartoma of the eye (HP:0010568)1.73175156
137Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72886346
138Hypoplastic pelvis (HP:0008839)1.72055539
139Neonatal death (HP:0003811)1.71466372
140Generalized amyotrophy (HP:0003700)1.71057512
141Inguinal hernia (HP:0000023)1.70222364
142Abnormality of the foot musculature (HP:0001436)1.69773901
143Hammertoe (HP:0001765)1.69728184
144Ovoid vertebral bodies (HP:0003300)1.69612279
145Axonal loss (HP:0003447)1.69547932
146Skin nodule (HP:0200036)1.69507641
147Tetraparesis (HP:0002273)1.68715036
148Hydroxyprolinuria (HP:0003080)1.68564722
149Abnormality of proline metabolism (HP:0010907)1.68564722
150Aortic valve stenosis (HP:0001650)1.67461247
151Hemangiomatosis (HP:0007461)1.67283919
152Upper limb amyotrophy (HP:0009129)1.67277187
153Distal upper limb amyotrophy (HP:0007149)1.67277187
154Round ear (HP:0100830)1.66444390
155Neck muscle weakness (HP:0000467)1.66392474
156Femoral bowing (HP:0002980)1.65971972
157Epiphyseal dysplasia (HP:0002656)1.65390889
158Achilles tendon contracture (HP:0001771)1.65150766
159Wide anterior fontanel (HP:0000260)1.64763698
160Vertebral hypoplasia (HP:0008417)1.64412657
161Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64412657
162Nausea (HP:0002018)1.64112249
163Osteopenia (HP:0000938)1.63466960
164Delayed cranial suture closure (HP:0000270)1.62857727
165Disproportionate tall stature (HP:0001519)1.61738308
166Myocardial infarction (HP:0001658)1.60537784
167Overgrowth (HP:0001548)1.59741798
168Amyloidosis (HP:0011034)1.55664246
169Pectus carinatum (HP:0000768)1.53405583
170Ankyloglossia (HP:0010296)1.51566470
171Abnormality of oral frenula (HP:0000190)1.51268302

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.82082460
2TRIB33.50386675
3PBK3.42847701
4ACVR1B2.88115786
5LMTK22.79610679
6EPHB12.27312353
7PAK42.26910691
8STK392.24841800
9PDK32.21112287
10PDK42.21112287
11WNK41.94475993
12ERN11.94168161
13EPHB21.93140497
14MYLK1.90871501
15TSSK61.88832542
16TTK1.87590035
17RIPK11.86401167
18PHKG21.80683172
19PHKG11.80683172
20PIK3CA1.80260075
21DDR21.79438438
22MET1.74887393
23FLT31.73149976
24SIK11.71366860
25PDGFRA1.71053659
26EPHA21.61271595
27ICK1.60000755
28PAK31.59624691
29EIF2AK11.57046261
30EPHA31.54585210
31FGFR21.53105609
32BCKDK1.52350028
33NEK11.51258390
34MAP3K121.47854497
35ERBB41.45124498
36NTRK11.43507511
37MST1R1.43442142
38PTK2B1.43282500
39PLK31.42648594
40TGFBR11.42215136
41FGFR41.41572883
42PKN21.39706337
43CAMK1D1.39041402
44DMPK1.38675908
45TESK11.38325189
46TESK21.35391066
47PTK21.33371489
48PDK21.31316048
49PTK61.28903955
50FER1.28501967
51CAMK1G1.22314666
52AKT31.22250987
53LIMK11.22110079
54PNCK1.17495581
55BCR1.16227154
56ROCK21.15205975
57LRRK21.15154979
58TRPM71.14867062
59TNIK1.13095976
60EIF2AK31.10616835
61GRK11.09504205
62ABL21.08736135
63RET1.05250852
64PRKD31.05203928
65ROCK11.00427796
66NEK90.99851688
67TRIM280.99067621
68PIM20.98883395
69PRKD10.95843538
70TGFBR20.95019552
71PDGFRB0.92352114
72BMX0.91293714
73PAK60.88218427
74MAP2K10.87258132
75PKN10.85819522
76ILK0.84523296
77OBSCN0.82637015
78STK30.81173907
79WNK10.80990017
80WNK30.80644313
81MAP3K80.80307900
82PAK20.78564724
83BRAF0.77030873
84KSR10.75512453
85SGK4940.74392324
86SGK2230.74392324
87PLK20.72698113
88PAK10.72212667
89CASK0.71203494
90BRSK20.70913585
91MKNK20.69238983
92CAMK2D0.66063758
93KSR20.65708609
94MAP3K30.64881288
95PRKG20.64631578
96ADRBK10.64591974
97DYRK20.64450519
98FGR0.63392012
99MAPKAPK50.63063242
100BUB10.63016543
101STK240.62430619
102LATS20.59551243
103ITK0.58705095
104WEE10.58250789
105FGFR10.58178214
106EEF2K0.56890434
107MAP2K20.56640171
108CLK10.56224915
109MARK10.56103543
110DAPK30.56019708
111GSK3A0.55786916
112NTRK20.55329683
113MOS0.54796684
114PRKD20.54068994
115FGFR30.53362254
116STK160.53314879
117PLK10.53002910
118ARAF0.51803286
119PRKCE0.50956174
120DYRK30.50347891
121PRKCH0.49214535
122OXSR10.47365612
123MST40.46751217
124STK380.46625619
125STK100.45765773
126MAPK120.44945582
127SRC0.44546634
128RPS6KA20.44411135
129MAPKAPK30.43280166
130PRKAA20.43027923
131CDC42BPA0.41754016
132TIE10.40725318
133BMPR1B0.39307169
134LATS10.39095847
135IRAK30.37704755
136KDR0.37267619
137MAP2K30.36870210
138PIK3CG0.36022228
139STK38L0.35020757
140TBK10.34998540
141MKNK10.34924885
142RAF10.34326595
143MAPKAPK20.33969233
144GRK70.33763589
145PRKCI0.32944147
146PRKACG0.32856684
147ADRBK20.32685477
148PDPK10.32523200
149JAK10.32478818
150CAMK2G0.31651798
151IRAK10.31121645
152FYN0.30130733
153MAP3K20.30086628

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58808003
2Propanoate metabolism_Homo sapiens_hsa006402.55835888
3Fatty acid metabolism_Homo sapiens_hsa012122.54254035
4Vitamin digestion and absorption_Homo sapiens_hsa049772.47957168
5Fatty acid elongation_Homo sapiens_hsa000622.34515862
6Fatty acid degradation_Homo sapiens_hsa000712.25558325
7PPAR signaling pathway_Homo sapiens_hsa033202.15125399
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05542661
9Glutathione metabolism_Homo sapiens_hsa004802.00218525
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96137552
11Galactose metabolism_Homo sapiens_hsa000521.92889105
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88430712
13Fatty acid biosynthesis_Homo sapiens_hsa000611.87094808
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.78647467
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77091051
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.76423564
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.75733489
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74861312
19Other glycan degradation_Homo sapiens_hsa005111.71743872
20ECM-receptor interaction_Homo sapiens_hsa045121.70368154
21Pyruvate metabolism_Homo sapiens_hsa006201.65605115
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.61468895
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59247818
24Steroid biosynthesis_Homo sapiens_hsa001001.55109243
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49058315
26Dilated cardiomyopathy_Homo sapiens_hsa054141.48821298
27Protein export_Homo sapiens_hsa030601.48166377
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39022064
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.34814429
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34108690
31Sulfur metabolism_Homo sapiens_hsa009201.31292586
32Focal adhesion_Homo sapiens_hsa045101.30068879
33Fructose and mannose metabolism_Homo sapiens_hsa000511.29249629
34Butanoate metabolism_Homo sapiens_hsa006501.26155836
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23656794
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21568701
37Carbon metabolism_Homo sapiens_hsa012001.19707145
38Fat digestion and absorption_Homo sapiens_hsa049751.15060311
39N-Glycan biosynthesis_Homo sapiens_hsa005101.13714965
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.12478288
41Biosynthesis of amino acids_Homo sapiens_hsa012301.12265441
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12102148
43Glycerolipid metabolism_Homo sapiens_hsa005611.11201610
44Cardiac muscle contraction_Homo sapiens_hsa042601.10626314
45Protein digestion and absorption_Homo sapiens_hsa049741.07805484
46Pentose phosphate pathway_Homo sapiens_hsa000301.07427712
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05496613
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01823539
49Arginine biosynthesis_Homo sapiens_hsa002200.99382631
50AMPK signaling pathway_Homo sapiens_hsa041520.91820130
51Amoebiasis_Homo sapiens_hsa051460.89488578
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.88606456
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.88050060
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87596354
55Insulin resistance_Homo sapiens_hsa049310.86735356
56Renal cell carcinoma_Homo sapiens_hsa052110.85346818
57Axon guidance_Homo sapiens_hsa043600.84849320
58TGF-beta signaling pathway_Homo sapiens_hsa043500.84776574
59Selenocompound metabolism_Homo sapiens_hsa004500.83706407
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83530393
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82692536
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82557070
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81335896
64Viral myocarditis_Homo sapiens_hsa054160.80582026
65Tight junction_Homo sapiens_hsa045300.77398647
66Proteasome_Homo sapiens_hsa030500.76951543
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75918627
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75523917
69Lysosome_Homo sapiens_hsa041420.75269878
70Adherens junction_Homo sapiens_hsa045200.74002630
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73625125
72Chemical carcinogenesis_Homo sapiens_hsa052040.73071645
73Caffeine metabolism_Homo sapiens_hsa002320.73043135
74Histidine metabolism_Homo sapiens_hsa003400.72835110
75Peroxisome_Homo sapiens_hsa041460.72470440
76beta-Alanine metabolism_Homo sapiens_hsa004100.72374890
77Tryptophan metabolism_Homo sapiens_hsa003800.71822912
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71817338
79Folate biosynthesis_Homo sapiens_hsa007900.70070903
80Proteoglycans in cancer_Homo sapiens_hsa052050.70065502
81Hippo signaling pathway_Homo sapiens_hsa043900.69334571
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67935871
83Phagosome_Homo sapiens_hsa041450.67869893
84Ether lipid metabolism_Homo sapiens_hsa005650.67848996
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67538438
86Phenylalanine metabolism_Homo sapiens_hsa003600.67457800
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66203347
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64491116
89VEGF signaling pathway_Homo sapiens_hsa043700.64463385
90Insulin signaling pathway_Homo sapiens_hsa049100.62639882
91Vitamin B6 metabolism_Homo sapiens_hsa007500.62557715
92Metabolic pathways_Homo sapiens_hsa011000.62457289
93Renin secretion_Homo sapiens_hsa049240.62043057
94Retinol metabolism_Homo sapiens_hsa008300.62010184
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61736081
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61237947
97Oxidative phosphorylation_Homo sapiens_hsa001900.60351593
98Malaria_Homo sapiens_hsa051440.59059438
99Bile secretion_Homo sapiens_hsa049760.58452415
100Dorso-ventral axis formation_Homo sapiens_hsa043200.57703579
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57436267
102Sphingolipid metabolism_Homo sapiens_hsa006000.55947784
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55944313
104Endocytosis_Homo sapiens_hsa041440.55618802
105Alzheimers disease_Homo sapiens_hsa050100.55440311
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.54255820
107Parkinsons disease_Homo sapiens_hsa050120.53789677
108Starch and sucrose metabolism_Homo sapiens_hsa005000.53522355
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52774171
110Mineral absorption_Homo sapiens_hsa049780.52671577
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.52301325
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.51668405
113Sulfur relay system_Homo sapiens_hsa041220.49048452
114Bladder cancer_Homo sapiens_hsa052190.48571035
115Tyrosine metabolism_Homo sapiens_hsa003500.48416930
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48412177
117Linoleic acid metabolism_Homo sapiens_hsa005910.46819426
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46764500
119Vibrio cholerae infection_Homo sapiens_hsa051100.46722548
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.46621492
121Arginine and proline metabolism_Homo sapiens_hsa003300.46105949
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.45354981
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.45335879
124Toxoplasmosis_Homo sapiens_hsa051450.44702375
125Glucagon signaling pathway_Homo sapiens_hsa049220.44243743
126Shigellosis_Homo sapiens_hsa051310.44234828
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43618128
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43330370
129Pancreatic cancer_Homo sapiens_hsa052120.43191413
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42214217
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41110306
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40271894
133Renin-angiotensin system_Homo sapiens_hsa046140.38869044
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38178481
135Gastric acid secretion_Homo sapiens_hsa049710.37569374
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37558866
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37496921
138Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36837249
139Thyroid hormone synthesis_Homo sapiens_hsa049180.36628597
140Arachidonic acid metabolism_Homo sapiens_hsa005900.36289392
141Platelet activation_Homo sapiens_hsa046110.35926200
142HIF-1 signaling pathway_Homo sapiens_hsa040660.32766390
143Complement and coagulation cascades_Homo sapiens_hsa046100.32053203
144Type II diabetes mellitus_Homo sapiens_hsa049300.31421533
145Rap1 signaling pathway_Homo sapiens_hsa040150.30768887

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