ANO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ANO2 belongs to a family of calcium-activated chloride channels (CaCCs) (reviewed by Hartzell et al., 2009 [PubMed 19015192]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.43493728
2fusion of sperm to egg plasma membrane (GO:0007342)9.24619893
3regulation of rhodopsin mediated signaling pathway (GO:0022400)9.12929581
4rhodopsin mediated signaling pathway (GO:0016056)9.02660645
5acrosome reaction (GO:0007340)8.65007520
6microtubule depolymerization (GO:0007019)8.11246656
7photoreceptor cell maintenance (GO:0045494)7.86949659
8retinal rod cell development (GO:0046548)7.70310564
9retinal cone cell development (GO:0046549)7.61757366
10plasma membrane fusion (GO:0045026)7.36282777
11sensory perception of chemical stimulus (GO:0007606)7.25235755
12chromosome condensation (GO:0030261)7.18396546
13photoreceptor cell development (GO:0042461)7.05776455
14DNA packaging (GO:0006323)6.93934199
15microtubule polymerization or depolymerization (GO:0031109)6.51008011
16detection of light stimulus involved in visual perception (GO:0050908)6.42248743
17detection of light stimulus involved in sensory perception (GO:0050962)6.42248743
18eye photoreceptor cell development (GO:0042462)6.29026183
19phototransduction (GO:0007602)6.24660446
20sperm capacitation (GO:0048240)6.16726145
21protein targeting to Golgi (GO:0000042)6.13136081
22establishment of protein localization to Golgi (GO:0072600)6.03194775
23retrograde transport, vesicle recycling within Golgi (GO:0000301)6.01227872
24detection of light stimulus (GO:0009583)5.99248748
25phototransduction, visible light (GO:0007603)5.97619719
26spermatid development (GO:0007286)5.95884075
27protein localization to cilium (GO:0061512)5.94638892
28detection of visible light (GO:0009584)5.76947852
29sperm-egg recognition (GO:0035036)5.71609172
30spermatid nucleus differentiation (GO:0007289)5.68662786
31single strand break repair (GO:0000012)5.67532383
32GMP metabolic process (GO:0046037)5.39164446
33multicellular organism reproduction (GO:0032504)5.37217405
34visual perception (GO:0007601)5.25859050
35sensory perception of light stimulus (GO:0050953)5.22083976
36binding of sperm to zona pellucida (GO:0007339)5.20537452
37regulation of centriole replication (GO:0046599)5.15513104
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.04675116
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98235786
40spermatogenesis (GO:0007283)4.97906033
41protein insertion into membrane (GO:0051205)4.96240109
42male gamete generation (GO:0048232)4.96215305
43centriole replication (GO:0007099)4.91076618
44negative regulation of cytosolic calcium ion concentration (GO:0051481)4.88283845
45negative regulation of inclusion body assembly (GO:0090084)4.87859370
46eye photoreceptor cell differentiation (GO:0001754)4.85829407
47photoreceptor cell differentiation (GO:0046530)4.85829407
48reproduction (GO:0000003)4.80715255
49rRNA methylation (GO:0031167)4.80593350
50response to pheromone (GO:0019236)4.77729777
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.71417704
52calcium ion-dependent exocytosis (GO:0017156)4.71329665
53motile cilium assembly (GO:0044458)4.64766401
54protein-chromophore linkage (GO:0018298)4.63543653
55cell-cell recognition (GO:0009988)4.55881271
56gamete generation (GO:0007276)4.55142390
57positive regulation of endothelial cell differentiation (GO:0045603)4.52045417
58axonemal dynein complex assembly (GO:0070286)4.50038323
59regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39013907
60positive regulation of guanylate cyclase activity (GO:0031284)4.35755004
61cellular potassium ion homeostasis (GO:0030007)4.33301317
62protein localization to Golgi apparatus (GO:0034067)4.33234623
63cilium or flagellum-dependent cell motility (GO:0001539)4.30027584
64centriole assembly (GO:0098534)4.25808505
65detection of external stimulus (GO:0009581)4.24345593
66dopamine receptor signaling pathway (GO:0007212)4.21531455
67retina development in camera-type eye (GO:0060041)4.20370336
68detection of abiotic stimulus (GO:0009582)4.18489647
69striatum development (GO:0021756)4.17358309
70regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.13928864
71regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.13928864
72nuclear pore complex assembly (GO:0051292)4.13212589
73behavioral response to cocaine (GO:0048148)4.11791860
74single fertilization (GO:0007338)4.10402683
75positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.09505253
76synaptic vesicle maturation (GO:0016188)4.05994612
77sexual reproduction (GO:0019953)4.03623276
78axoneme assembly (GO:0035082)3.99800969
79positive regulation of Rab GTPase activity (GO:0032851)3.96976478
80regulation of Rab GTPase activity (GO:0032313)3.96976478
81seminiferous tubule development (GO:0072520)3.96144662
82synaptic transmission, dopaminergic (GO:0001963)3.94559102
83regulation of voltage-gated calcium channel activity (GO:1901385)3.93386487
84synaptic vesicle docking involved in exocytosis (GO:0016081)3.92622630
85regulation of guanylate cyclase activity (GO:0031282)3.90664193
86phosphatidylethanolamine biosynthetic process (GO:0006646)3.85836967
87regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.85331016
88rRNA modification (GO:0000154)3.82853077
89glomerular visceral epithelial cell development (GO:0072015)3.82749481
90protein localization to synapse (GO:0035418)3.79222124
91regulation of endothelial cell differentiation (GO:0045601)3.78393050
92cellular response to light stimulus (GO:0071482)3.77831773
93potassium ion homeostasis (GO:0055075)3.73438872
94fertilization (GO:0009566)3.71345461
95layer formation in cerebral cortex (GO:0021819)3.68039575
96peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.67160592
97regulation of cilium movement (GO:0003352)3.63149044
98positive regulation of neurotransmitter transport (GO:0051590)3.61704057
99multicellular organismal reproductive process (GO:0048609)3.60848946
100nonmotile primary cilium assembly (GO:0035058)3.58558896
101regulation of synaptic vesicle exocytosis (GO:2000300)3.53343844
102regulation of clathrin-mediated endocytosis (GO:2000369)3.52482311
103multicellular organismal movement (GO:0050879)3.52465347
104musculoskeletal movement (GO:0050881)3.52465347
105mating behavior (GO:0007617)3.49845028
106phosphatidylethanolamine metabolic process (GO:0046337)3.49000694
107glomerular epithelial cell development (GO:0072310)3.48818644
108microtubule nucleation (GO:0007020)3.48086752
109sensory perception (GO:0007600)3.48023903
110neurotransmitter-gated ion channel clustering (GO:0072578)3.46332628
111chemosensory behavior (GO:0007635)3.44925806
112germ cell development (GO:0007281)3.44415512
113glutamate secretion (GO:0014047)3.44288744
114synaptic vesicle exocytosis (GO:0016079)3.43998445
115cellular process involved in reproduction in multicellular organism (GO:0022412)3.42073758
116polyamine biosynthetic process (GO:0006596)3.41982605
117regulation of inclusion body assembly (GO:0090083)3.40161081
118protein polyglutamylation (GO:0018095)3.35695870
119epithelial cilium movement (GO:0003351)3.34647194
120nucleus organization (GO:0006997)3.33779646
121regulation of synapse structural plasticity (GO:0051823)3.33399157
122estrogen biosynthetic process (GO:0006703)3.28000408
123positive regulation of synapse maturation (GO:0090129)3.27169514
124potassium ion export (GO:0071435)3.23130903
125behavioral response to ethanol (GO:0048149)3.20659170
126cellular ketone body metabolic process (GO:0046950)3.19675817
127membrane hyperpolarization (GO:0060081)3.18730877
128nuclear pore organization (GO:0006999)3.14394329
129regulation of neurotransmitter uptake (GO:0051580)3.14327747
130potassium ion transmembrane transport (GO:0071805)3.13243250
131cellular potassium ion transport (GO:0071804)3.13243250
132response to amphetamine (GO:0001975)3.12743958
133activation of protein kinase A activity (GO:0034199)3.12169323
134cilium movement (GO:0003341)3.11519907
135regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.10752370
136regulation of synaptic vesicle transport (GO:1902803)3.07914292
137prepulse inhibition (GO:0060134)3.07659835
138pore complex assembly (GO:0046931)3.05695537
139response to histamine (GO:0034776)3.05280369
140phosphorelay signal transduction system (GO:0000160)3.04991285
141peptidyl-lysine dimethylation (GO:0018027)3.03185051
142regulation of centrosome duplication (GO:0010824)3.00584826
143regulation of female gonad development (GO:2000194)3.00361166
144regulation of somitogenesis (GO:0014807)2.98844544
145centrosome duplication (GO:0051298)2.97140006
146regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.95958673
147cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.95835932
148ketone body metabolic process (GO:1902224)2.94702223
149peristalsis (GO:0030432)2.94531242
150neuron cell-cell adhesion (GO:0007158)2.94295284
151paraxial mesoderm development (GO:0048339)2.93767181
152positive regulation of dendritic spine morphogenesis (GO:0061003)2.92633319
153microtubule severing (GO:0051013)2.90483670
154termination of G-protein coupled receptor signaling pathway (GO:0038032)2.89648435
155cilium morphogenesis (GO:0060271)2.85815435
156male meiosis (GO:0007140)2.84937989
157regulation of cGMP metabolic process (GO:0030823)2.83718319
158negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.82718612
159regulation of neurotransmitter secretion (GO:0046928)2.82351695
160CDP-diacylglycerol biosynthetic process (GO:0016024)2.82320311
161potassium ion transport (GO:0006813)2.79609406
162negative regulation of vascular permeability (GO:0043116)2.79408381
163positive regulation of membrane potential (GO:0045838)2.79013869
164negative regulation of cation channel activity (GO:2001258)2.78712873
165regulation of transcription involved in cell fate commitment (GO:0060850)2.78516005
166glycerol ether metabolic process (GO:0006662)2.76883667
167cell wall macromolecule metabolic process (GO:0044036)2.76547769
168cellular response to glucagon stimulus (GO:0071377)2.76084623
169intraciliary transport (GO:0042073)2.75732971
170RNA destabilization (GO:0050779)2.74970569
171response to auditory stimulus (GO:0010996)2.74120855
172regulation of neurotransmitter transport (GO:0051588)2.73502885
173histone H3-K9 demethylation (GO:0033169)2.73127763
174artery development (GO:0060840)2.71762407
175regulation of sodium ion transmembrane transporter activity (GO:2000649)2.69639219
176homeostasis of number of cells within a tissue (GO:0048873)2.69011806
177left/right axis specification (GO:0070986)2.68979298
178regulation of heart rate by cardiac conduction (GO:0086091)2.68608357
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68292825
180melanosome transport (GO:0032402)2.67886564
181mitochondrial fission (GO:0000266)2.65708088
182termination of signal transduction (GO:0023021)2.64683716
183peptidyl-glutamic acid modification (GO:0018200)2.61611895
184receptor recycling (GO:0001881)2.60577297
185myoblast fusion (GO:0007520)2.59883033
186cell wall macromolecule catabolic process (GO:0016998)2.59837376
187synaptonemal complex assembly (GO:0007130)2.59657198
188ether metabolic process (GO:0018904)2.57265860
189protein neddylation (GO:0045116)2.56793847
190negative regulation of Rho protein signal transduction (GO:0035024)2.56255358
191sensory perception of smell (GO:0007608)11.8660616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.77015895
2GBX2_23144817_ChIP-Seq_PC3_Human3.01397951
3DROSHA_22980978_ChIP-Seq_HELA_Human2.86779348
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68420091
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62585924
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.52400428
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51448053
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51448053
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30384209
10SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.27996694
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21380046
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21027318
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.17250754
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16990270
15REST_21632747_ChIP-Seq_MESCs_Mouse2.15348457
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13504674
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.06396884
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05713070
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01273388
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00257191
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97585226
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96814598
23* FUS_26573619_Chip-Seq_HEK293_Human1.93319234
24CBP_20019798_ChIP-Seq_JUKART_Human1.89740913
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.89740913
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.89413073
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.88686639
28CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.88675194
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86907292
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.84754220
31TAF15_26573619_Chip-Seq_HEK293_Human1.81235771
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.79893714
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74111728
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.73254706
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72108175
36KDM2B_26808549_Chip-Seq_K562_Human1.67793091
37* TBL1_22424771_ChIP-Seq_293T_Human1.65011344
38CBX2_22325352_ChIP-Seq_293T-Rex_Human1.60455939
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59042905
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57667184
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55640074
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54936530
43ER_23166858_ChIP-Seq_MCF-7_Human1.54884361
44HNFA_21074721_ChIP-Seq_CACO-2_Human1.54726616
45* NFYB_21822215_ChIP-Seq_K562_Human1.53892464
46AR_25329375_ChIP-Seq_VCAP_Human1.52454224
47ETV1_20927104_ChIP-Seq_GIST48_Human1.51517131
48RBPJ_21746931_ChIP-Seq_IB4_Human1.50868825
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49249811
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48600226
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46987167
52CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.44938752
53PHF8_20622853_ChIP-Seq_HELA_Human1.42370640
54SMAD4_21799915_ChIP-Seq_A2780_Human1.41466955
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40915986
56TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40047512
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.39985281
58CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39358642
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38627653
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38381024
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.36968667
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36315686
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.36279003
64RUNX1_26923725_Chip-Seq_HPCs_Mouse1.35376043
65PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.35371449
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34333366
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33928333
68* NFYA_21822215_ChIP-Seq_K562_Human1.32306761
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29960467
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26491635
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26156385
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25826954
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25647866
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25427332
75VDR_22108803_ChIP-Seq_LS180_Human1.25181676
76SMAD3_21741376_ChIP-Seq_HESCs_Human1.24927387
77WDR5_24793694_ChIP-Seq_LNCAP_Human1.24924607
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22806777
79CJUN_26792858_Chip-Seq_BT549_Human1.22800295
80* STAT3_23295773_ChIP-Seq_U87_Human1.22018437
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21517333
82AHR_22903824_ChIP-Seq_MCF-7_Human1.21474859
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21095744
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18370515
85TP53_18474530_ChIP-ChIP_U2OS_Human1.18280799
86AR_19668381_ChIP-Seq_PC3_Human1.18254108
87* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16631941
88RNF2_27304074_Chip-Seq_NSC_Mouse1.16577949
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.15517366
90EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14970619
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.14946965
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12417260
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12417260
94E2F7_22180533_ChIP-Seq_HELA_Human1.11901166
95MYC_19829295_ChIP-Seq_ESCs_Human1.11461317
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11092279
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10422124
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.09713340
99* KDM2B_26808549_Chip-Seq_REH_Human1.09594558
100ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09421598
101SMAD4_21741376_ChIP-Seq_HESCs_Human1.09378379
102TAF2_19829295_ChIP-Seq_ESCs_Human1.08716938
103* CTCF_27219007_Chip-Seq_Bcells_Human1.08387679
104ERA_21632823_ChIP-Seq_H3396_Human1.08373856
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08368380
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.08324086
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08205551
108AR_21572438_ChIP-Seq_LNCaP_Human1.07447461
109NANOG_20526341_ChIP-Seq_ESCs_Human1.07063741
110ERG_20517297_ChIP-Seq_VCAP_Human1.06066705
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.05857437
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04165955
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03692356
114RAC3_21632823_ChIP-Seq_H3396_Human1.03369031
115OCT1_27270436_Chip-Seq_PROSTATE_Human1.03183937
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02704101
117GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02062580
118* GATA3_21878914_ChIP-Seq_MCF-7_Human1.01898808
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.01550640
120TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01533198
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01387382
122NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01322063
123* P300_19829295_ChIP-Seq_ESCs_Human1.01162709
124TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00846741
125* GF1_26923725_Chip-Seq_HPCs_Mouse1.00702190
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00095411
127SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00006171
128* SOX2_19829295_ChIP-Seq_ESCs_Human0.98849359
129* NANOG_19829295_ChIP-Seq_ESCs_Human0.98849359
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.98460936
131TP63_22573176_ChIP-Seq_HFKS_Human0.97831247
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97217564
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.96822516
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96706923
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96667612
136SOX2_21211035_ChIP-Seq_LN229_Gbm0.96107185
137BCAT_22108803_ChIP-Seq_LS180_Human0.95922559
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93860313
139* CBP_21632823_ChIP-Seq_H3396_Human0.93321210
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93101152
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92626383
142SMC4_20622854_ChIP-Seq_HELA_Human0.92304154
143SMAD4_21741376_ChIP-Seq_ESCs_Human0.91719450
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.90626090
145RUNX2_22187159_ChIP-Seq_PCA_Human0.90278662
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89588934
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89191781
148* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88849103
149POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88455287
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87768602
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87564483
152NCOR_22424771_ChIP-Seq_293T_Human0.85493860
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.85299263
154TCF4_23295773_ChIP-Seq_U87_Human0.85259776
155SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84603818
156ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84396686
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.84220891
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83992136
159* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83981985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction8.77438805
2MP0005551_abnormal_eye_electrophysiolog6.48960682
3MP0003011_delayed_dark_adaptation5.73594508
4MP0005670_abnormal_white_adipose4.26680598
5MP0005253_abnormal_eye_physiology4.05795078
6MP0005499_abnormal_olfactory_system3.98551262
7MP0005394_taste/olfaction_phenotype3.98551262
8MP0006072_abnormal_retinal_apoptosis3.98264563
9MP0008789_abnormal_olfactory_epithelium3.83028984
10MP0002822_catalepsy3.42022824
11MP0003698_abnormal_male_reproductive3.02906002
12MP0003646_muscle_fatigue3.00455093
13MP0005195_abnormal_posterior_eye2.80480680
14MP0009697_abnormal_copulation2.76848871
15MP0004859_abnormal_synaptic_plasticity2.66374570
16MP0001929_abnormal_gametogenesis2.64428121
17MP0005167_abnormal_blood-brain_barrier2.63295329
18MP0004084_abnormal_cardiac_muscle2.34845161
19MP0002653_abnormal_ependyma_morphology2.29292042
20MP0010368_abnormal_lymphatic_system2.22087974
21MP0001324_abnormal_eye_pigmentation2.18958843
22MP0002229_neurodegeneration2.12714622
23MP0005391_vision/eye_phenotype2.10406336
24MP0002752_abnormal_somatic_nervous2.07939376
25MP0004036_abnormal_muscle_relaxation2.05976755
26MP0005423_abnormal_somatic_nervous1.98964796
27MP0003635_abnormal_synaptic_transmissio1.95129024
28MP0001486_abnormal_startle_reflex1.93629934
29MP0001879_abnormal_lymphatic_vessel1.93393687
30MP0002090_abnormal_vision1.93066652
31MP0003880_abnormal_central_pattern1.85850258
32MP0004270_analgesia1.81180149
33MP0006138_congestive_heart_failure1.77223324
34MP0002882_abnormal_neuron_morphology1.72440874
35MP0002638_abnormal_pupillary_reflex1.72419292
36MP0002184_abnormal_innervation1.70901768
37MP0003136_yellow_coat_color1.69255440
38MP0001348_abnormal_lacrimal_gland1.68129196
39MP0002161_abnormal_fertility/fecundity1.64089402
40MP0002272_abnormal_nervous_system1.61337353
41MP0002063_abnormal_learning/memory/cond1.60910913
42MP0002734_abnormal_mechanical_nocicepti1.55576113
43MP0001502_abnormal_circadian_rhythm1.51233800
44MP0003718_maternal_effect1.49689975
45MP0005379_endocrine/exocrine_gland_phen1.48422611
46MP0006292_abnormal_olfactory_placode1.47377395
47MP0005666_abnormal_adipose_tissue1.46335100
48MP0002210_abnormal_sex_determination1.41966212
49MP0009745_abnormal_behavioral_response1.36932024
50MP0008004_abnormal_stomach_pH1.35190086
51MP0001485_abnormal_pinna_reflex1.33808107
52MP0002064_seizures1.31343864
53MP0009046_muscle_twitch1.30725116
54MP0004510_myositis1.29042431
55MP0005464_abnormal_platelet_physiology1.28452621
56MP0002572_abnormal_emotion/affect_behav1.25713588
57MP0004885_abnormal_endolymph1.21302401
58MP0005187_abnormal_penis_morphology1.21274649
59MP0000230_abnormal_systemic_arterial1.20713761
60MP0000749_muscle_degeneration1.20710813
61MP0010386_abnormal_urinary_bladder1.20120193
62MP0004484_altered_response_of1.18118206
63MP0008775_abnormal_heart_ventricle1.18093247
64MP0000049_abnormal_middle_ear1.15321745
65MP0002909_abnormal_adrenal_gland1.14554246
66MP0009115_abnormal_fat_cell1.12857275
67MP0002067_abnormal_sensory_capabilities1.12618888
68MP0003137_abnormal_impulse_conducting1.08022580
69MP0005451_abnormal_body_composition1.07676171
70MP0000751_myopathy1.07151338
71MP0003828_pulmonary_edema1.05919955
72MP0002557_abnormal_social/conspecific_i1.05860492
73MP0005375_adipose_tissue_phenotype1.05331318
74MP0003787_abnormal_imprinting1.05311839
75MP0010030_abnormal_orbit_morphology1.03402999
76MP0002102_abnormal_ear_morphology1.02441914
77MP0005620_abnormal_muscle_contractility1.01886363
78MP0004272_abnormal_basement_membrane1.01457561
79MP0000013_abnormal_adipose_tissue1.00188244
80MP0000653_abnormal_sex_gland0.99841858
81MP0002163_abnormal_gland_morphology0.98901358
82MP0002837_dystrophic_cardiac_calcinosis0.98899454
83MP0005645_abnormal_hypothalamus_physiol0.98312549
84MP0001145_abnormal_male_reproductive0.97492703
85MP0001529_abnormal_vocalization0.95884227
86MP0004811_abnormal_neuron_physiology0.95401302
87MP0000778_abnormal_nervous_system0.94855361
88MP0001968_abnormal_touch/_nociception0.94094141
89MP0003879_abnormal_hair_cell0.90140248
90MP0004742_abnormal_vestibular_system0.88854844
91MP0002233_abnormal_nose_morphology0.84570852
92MP0003634_abnormal_glial_cell0.83261572
93MP0002152_abnormal_brain_morphology0.82413510
94MP0005646_abnormal_pituitary_gland0.82263290
95MP0005647_abnormal_sex_gland0.82051386
96MP0005395_other_phenotype0.81160040
97MP0001963_abnormal_hearing_physiology0.81126161
98MP0000631_abnormal_neuroendocrine_gland0.81062853
99MP0001544_abnormal_cardiovascular_syste0.80140534
100MP0005385_cardiovascular_system_phenoty0.80140534
101MP0001970_abnormal_pain_threshold0.79663109
102MP0005595_abnormal_vascular_smooth0.79558658
103MP0000003_abnormal_adipose_tissue0.79542861
104MP0002972_abnormal_cardiac_muscle0.77567069
105MP0005197_abnormal_uvea_morphology0.77424724
106MP0001501_abnormal_sleep_pattern0.77181309
107MP0004924_abnormal_behavior0.76631947
108MP0005386_behavior/neurological_phenoty0.76631947
109MP0002697_abnormal_eye_size0.75887318
110MP0003950_abnormal_plasma_membrane0.74831113
111MP0002269_muscular_atrophy0.74762639
112MP0004087_abnormal_muscle_fiber0.73999511
113MP0005623_abnormal_meninges_morphology0.73673986
114MP0010234_abnormal_vibrissa_follicle0.73050105
115MP0001661_extended_life_span0.72443739
116MP0008569_lethality_at_weaning0.67721577
117MP0002106_abnormal_muscle_physiology0.66814094
118MP0005171_absent_coat_pigmentation0.66307308
119MP0010630_abnormal_cardiac_muscle0.65832574
120MP0001293_anophthalmia0.65118488
121MP0001188_hyperpigmentation0.64294190
122MP0002066_abnormal_motor_capabilities/c0.64293905
123MP0002128_abnormal_blood_circulation0.60400446
124MP0004233_abnormal_muscle_weight0.60184858
125MP0003077_abnormal_cell_cycle0.60065060
126MP0000733_abnormal_muscle_development0.59952942
127MP0002234_abnormal_pharynx_morphology0.59149462
128MP0002108_abnormal_muscle_morphology0.58775487
129MP0003878_abnormal_ear_physiology0.58020599
130MP0005377_hearing/vestibular/ear_phenot0.58020599
131MP0005369_muscle_phenotype0.57645478
132MP0003633_abnormal_nervous_system0.56962625
133MP0009053_abnormal_anal_canal0.56852251
134MP0004130_abnormal_muscle_cell0.56491821
135MP0001764_abnormal_homeostasis0.56397630
136MP0000343_altered_response_to0.56120248
137MP0003861_abnormal_nervous_system0.54843688
138MP0000026_abnormal_inner_ear0.54644015
139MP0000955_abnormal_spinal_cord0.54379685
140MP0008961_abnormal_basal_metabolism0.54221282
141MP0001905_abnormal_dopamine_level0.54142889
142MP0002735_abnormal_chemical_nociception0.52848875
143MP0000249_abnormal_blood_vessel0.52606086
144MP0001614_abnormal_blood_vessel0.51985888
145MP0001286_abnormal_eye_development0.51757128
146MP0002928_abnormal_bile_duct0.51459621
147MP0004085_abnormal_heartbeat0.50519443
148MP0004215_abnormal_myocardial_fiber0.50109849
149MP0006276_abnormal_autonomic_nervous0.49034556
150MP0008875_abnormal_xenobiotic_pharmacok0.48397573
151MP0002332_abnormal_exercise_endurance0.46750610
152MP0004019_abnormal_vitamin_homeostasis0.44051257
153MP0008874_decreased_physiological_sensi0.43649612
154MP0003075_altered_response_to0.42634117
155MP0001177_atelectasis0.41971148
156MP0002127_abnormal_cardiovascular_syste0.40554713
157MP0003631_nervous_system_phenotype0.39379814
158MP0005410_abnormal_fertilization0.39291335
159MP0002733_abnormal_thermal_nociception0.38912384
160MP0008872_abnormal_physiological_respon0.38717509
161MP0000534_abnormal_ureter_morphology0.38088458
162MP0003890_abnormal_embryonic-extraembry0.37969234
163MP0002160_abnormal_reproductive_system0.37768417
164MP0005248_abnormal_Harderian_gland0.36995171
165MP0002069_abnormal_eating/drinking_beha0.36039660
166MP0005084_abnormal_gallbladder_morpholo0.35870486

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.91973648
2Absent rod-and cone-mediated responses on ERG (HP:0007688)9.10527325
3Abnormal rod and cone electroretinograms (HP:0008323)8.51907925
4Abnormality of macular pigmentation (HP:0008002)7.87032361
5Central scotoma (HP:0000603)7.52176732
6Chorioretinal atrophy (HP:0000533)7.39075397
7Abolished electroretinogram (ERG) (HP:0000550)7.18910433
8Pigmentary retinal degeneration (HP:0001146)6.81743416
9Scotoma (HP:0000575)6.34533576
10Pendular nystagmus (HP:0012043)5.89758255
11Dyschromatopsia (HP:0007641)5.65037187
12Posterior subcapsular cataract (HP:0007787)5.06407764
13Tubulointerstitial nephritis (HP:0001970)5.06355788
14Type II diabetes mellitus (HP:0005978)4.92602907
15Attenuation of retinal blood vessels (HP:0007843)4.90055872
16Constricted visual fields (HP:0001133)4.70706294
17Decreased central vision (HP:0007663)4.58923101
18Photophobia (HP:0000613)4.48073782
19Severe visual impairment (HP:0001141)4.29278571
20Absent/shortened dynein arms (HP:0200106)4.25859480
21Dynein arm defect of respiratory motile cilia (HP:0012255)4.25859480
22Increased corneal curvature (HP:0100692)4.14639166
23Keratoconus (HP:0000563)4.14639166
24Retinitis pigmentosa (HP:0000510)4.06843815
25Vitreoretinal degeneration (HP:0000655)4.06811974
26Cone-rod dystrophy (HP:0000548)3.84588701
27Macular degeneration (HP:0000608)3.73523521
28Asymmetric septal hypertrophy (HP:0001670)3.60318649
29Menorrhagia (HP:0000132)3.60077490
30Abnormality of the ischium (HP:0003174)3.56002016
31Menstrual irregularities (HP:0000858)3.41820603
32Portal hypertension (HP:0001409)3.31907008
33Gait imbalance (HP:0002141)3.28262135
34Hypoalphalipoproteinemia (HP:0003233)3.26959793
35Hyperkalemia (HP:0002153)3.23538399
36Congenital primary aphakia (HP:0007707)3.20235633
37Subcapsular cataract (HP:0000523)3.14676617
38Infertility (HP:0000789)3.09599400
39Prolonged bleeding time (HP:0003010)3.08329575
40Male infertility (HP:0003251)3.08007437
41Abnormality of the hepatic vasculature (HP:0006707)3.06363397
42Choroideremia (HP:0001139)3.05482836
43Hypoplastic ischia (HP:0003175)3.02028996
44Myokymia (HP:0002411)2.99047493
45Nephrogenic diabetes insipidus (HP:0009806)2.98047746
46Abnormal auditory evoked potentials (HP:0006958)2.96570338
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.93328499
48Febrile seizures (HP:0002373)2.92156249
49Medial flaring of the eyebrow (HP:0010747)2.90385762
50Increased mean platelet volume (HP:0011877)2.88856018
51Progressive sensorineural hearing impairment (HP:0000408)2.75948407
52Molar tooth sign on MRI (HP:0002419)2.74674231
53Abnormality of midbrain morphology (HP:0002418)2.74674231
54Truncal obesity (HP:0001956)2.68889421
55Bell-shaped thorax (HP:0001591)2.64790370
56Renovascular hypertension (HP:0100817)2.58123353
57Optic nerve hypoplasia (HP:0000609)2.43961485
58True hermaphroditism (HP:0010459)2.43918941
59Pancreatic fibrosis (HP:0100732)2.43344514
60Vaginal atresia (HP:0000148)2.40909187
61Poor coordination (HP:0002370)2.40450456
62Abnormal platelet volume (HP:0011876)2.40137742
63Tubulointerstitial abnormality (HP:0001969)2.40059811
64Progressive visual loss (HP:0000529)2.38253961
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.38251210
66Genital tract atresia (HP:0001827)2.37051273
67Resting tremor (HP:0002322)2.36372999
68Ventricular tachycardia (HP:0004756)2.36241004
69Upper limb muscle weakness (HP:0003484)2.28766395
70Aplasia/Hypoplasia of the earlobes (HP:0009906)2.28621618
71Retinal dysplasia (HP:0007973)2.25717235
72Absence seizures (HP:0002121)2.22443956
73Abnormal respiratory motile cilium physiology (HP:0012261)2.21525728
74Impulsivity (HP:0100710)2.21075973
75Prolonged QT interval (HP:0001657)2.17070754
76Insulin-resistant diabetes mellitus (HP:0000831)2.15706584
77Bundle branch block (HP:0011710)2.13980672
78Abnormality of the nasal mucosa (HP:0000433)2.13658343
79Atonic seizures (HP:0010819)2.10717515
80Atrial fibrillation (HP:0005110)2.10531122
81Wide nasal bridge (HP:0000431)2.10260225
82Bifid tongue (HP:0010297)2.09960593
83Focal motor seizures (HP:0011153)2.09384891
84Retinal atrophy (HP:0001105)2.07926562
85Absent epiphyses (HP:0010577)2.07481845
86Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.07481845
87Epileptic encephalopathy (HP:0200134)2.07269912
88Stage 5 chronic kidney disease (HP:0003774)2.06234567
89Torticollis (HP:0000473)2.05203371
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04268660
91Limb dystonia (HP:0002451)2.01358335
92Focal seizures (HP:0007359)2.00592199
93Congenital stationary night blindness (HP:0007642)10.0325643
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98102669
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.97699644
96Hyperlipoproteinemia (HP:0010980)1.94277355
97Pancreatic cysts (HP:0001737)1.93180805
98Cerebellar dysplasia (HP:0007033)1.92507382
99Abnormal spermatogenesis (HP:0008669)1.91772187
100Cystic liver disease (HP:0006706)1.90592564
101Syncope (HP:0001279)1.87407367
102Primary atrial arrhythmia (HP:0001692)1.86709187
103Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86607338
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86168723
105Generalized aminoaciduria (HP:0002909)1.85885647
106Dysdiadochokinesis (HP:0002075)1.85852050
107Optic disc pallor (HP:0000543)1.84741584
108Aplasia/Hypoplasia of the lens (HP:0008063)1.84653392
109Abnormality of the renal medulla (HP:0100957)1.84525327
110Hypergonadotropic hypogonadism (HP:0000815)1.84505268
111Vertebral clefting (HP:0008428)1.84479909
112Esophageal varix (HP:0002040)1.84234392
113Facial shape deformation (HP:0011334)1.83663142
114Potter facies (HP:0002009)1.83663142
115Nasal polyposis (HP:0100582)1.83604491
116Visual hallucinations (HP:0002367)1.83575098
117Short palpebral fissure (HP:0012745)1.83548020
118Abnormal ciliary motility (HP:0012262)1.81745794
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81475469
120Myoglobinuria (HP:0002913)1.80930650
121Abnormality of the neuromuscular junction (HP:0003398)1.80740193
122Fatigable weakness (HP:0003473)1.80740193
123Dialeptic seizures (HP:0011146)1.80587053
124Esophageal atresia (HP:0002032)1.79001430
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78995642
126Postaxial hand polydactyly (HP:0001162)1.78040265
127Generalized tonic-clonic seizures (HP:0002069)1.77202723
128Abnormality of dental color (HP:0011073)1.76739066
129Distal lower limb muscle weakness (HP:0009053)1.76557410
130Postural instability (HP:0002172)1.75625011
131Abnormal EKG (HP:0003115)1.75557602
132Supraventricular tachycardia (HP:0004755)1.75295915
133Abdominal situs inversus (HP:0003363)1.75085028
134Abnormality of abdominal situs (HP:0011620)1.75085028
135Rhinitis (HP:0012384)1.74706903
136Sandal gap (HP:0001852)1.73449111
137Growth hormone deficiency (HP:0000824)1.72886643
138Supraventricular arrhythmia (HP:0005115)1.72605996
139Congenital sensorineural hearing impairment (HP:0008527)1.71824935
140Accelerated skeletal maturation (HP:0005616)1.69551000
141Progressive hearing impairment (HP:0001730)1.68612933
142Abnormality of potassium homeostasis (HP:0011042)1.68005285
143Exercise-induced muscle cramps (HP:0003710)1.67818772
144Anosmia (HP:0000458)1.67394707
145Nephronophthisis (HP:0000090)1.67223392
146Septo-optic dysplasia (HP:0100842)1.64940832
147Craniofacial dystonia (HP:0012179)1.64168491
148Abnormality of the lower motor neuron (HP:0002366)1.61289572
149Depression (HP:0000716)1.57111611
150Sclerocornea (HP:0000647)1.56361116
151Megalencephaly (HP:0001355)1.55637103
152Focal dystonia (HP:0004373)1.55294414
153Polar cataract (HP:0010696)1.52924857
154Chronic bronchitis (HP:0004469)1.52838491
155Horizontal nystagmus (HP:0000666)1.50580753
156Left ventricular hypertrophy (HP:0001712)1.48984080
157Abnormal respiratory motile cilium morphology (HP:0005938)1.48874386
158Abnormal respiratory epithelium morphology (HP:0012253)1.48874386
159Progressive cerebellar ataxia (HP:0002073)1.48321184
160Truncal ataxia (HP:0002078)1.47606789
161Optic atrophy (HP:0000648)1.45675394
162Furrowed tongue (HP:0000221)1.45117726
163Astigmatism (HP:0000483)1.44259392
164Specific learning disability (HP:0001328)1.43149077
165Occipital encephalocele (HP:0002085)1.40703974
166Dysphonia (HP:0001618)1.40515405
167Chronic hepatic failure (HP:0100626)1.38645483
168Abnormality of dentin (HP:0010299)1.36405042
169Congenital hepatic fibrosis (HP:0002612)1.36313320
170Insomnia (HP:0100785)1.34972847
171Anxiety (HP:0000739)1.34196962
172Oculomotor apraxia (HP:0000657)1.33449333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.19944919
2PBK6.77385215
3TIE14.25809606
4MAP4K23.87297488
5GRK13.57708766
6PNCK3.50148349
7INSRR3.43471427
8ERBB33.29698450
9EPHA43.11467632
10BRD42.79789359
11PHKG22.77948671
12PHKG12.77948671
13DDR22.73793917
14TESK12.57849757
15BMPR22.53247407
16PTK2B2.41121365
17PIK3CG2.38133103
18ARAF2.22877870
19MST1R2.17610574
20SIK22.06471572
21IRAK21.94970380
22PRKD31.88533649
23MAP3K91.85978943
24DAPK21.82330336
25CAMK2D1.81474578
26MAP3K41.73181753
27OBSCN1.72743954
28PINK11.66649141
29NEK11.66091982
30MYLK1.64279370
31MET1.58887827
32PAK61.54601863
33KSR21.52106697
34RIPK11.49581714
35BMX1.44630602
36MINK11.44404820
37NTRK21.42360311
38STK381.40376992
39PAK31.36999855
40KDR1.31980498
41SGK4941.31951786
42SGK2231.31951786
43NTRK31.31194145
44CAMKK11.31188959
45PRPF4B1.31067525
46MARK11.28641331
47MAP2K71.28159476
48TTN1.24031507
49CAMK2B1.17470191
50DYRK1A1.14400895
51ICK1.13862625
52CDK121.11889086
53PDPK11.11612388
54STK38L1.10122381
55MAP3K61.08767773
56MAP3K21.05045480
57KSR11.04538328
58CAMK1G0.99801100
59NEK60.98317667
60STK30.98153272
61HIPK20.96189637
62CDK70.94272751
63MAP3K130.94098184
64PDK10.93610963
65CDK190.92588119
66CSNK1G20.91530602
67DYRK1B0.90747426
68CDK50.90437865
69FES0.90262049
70CDK30.90168156
71GRK50.89775356
72MAPK150.89725897
73AKT30.89375358
74CAMK2G0.88225391
75PRKCG0.87663464
76CAMK1D0.86794493
77MAP2K40.83900628
78CAMK2A0.82836262
79MARK20.81227522
80PRKD20.80341501
81LMTK20.79131600
82STK110.77166424
83TEC0.77002096
84SGK20.76271444
85CSNK1A1L0.75484302
86MKNK10.70806316
87CDC70.70324930
88ROCK10.70010472
89PRKG20.69668209
90PRKAA10.69202611
91TRIB30.68585548
92TAOK10.68133355
93DAPK10.67111409
94CAMKK20.66551435
95ERBB20.66506119
96ADRBK20.66248400
97ZAK0.65005558
98PRKAA20.64446764
99NUAK10.63739955
100EPHB20.63443771
101PRKG10.62803004
102SGK30.61834426
103BMPR1B0.61613889
104STK390.60404033
105MAPK70.60397062
106BRAF0.59927133
107MUSK0.59784413
108TYRO30.59739091
109PRKCZ0.59670341
110RAF10.57263819
111PRKCH0.56982429
112CSNK1G30.56313895
113MAP3K100.55884391
114MTOR0.55422803
115MAP3K70.53258428
116CAMK10.52269267
117MAPK130.51783660
118BRSK20.50903959
119CDK140.50092775
120CAMK40.49550791
121TNIK0.48339449
122CSNK1G10.46677602
123OXSR10.46107869
124CDK90.45763719
125RPS6KA20.45421189
126LATS10.44952789
127AKT20.44650840
128MOS0.44491020
129TTK0.42816624
130PKN10.42374695
131TLK10.41535443
132CDK150.41113136
133LATS20.40165619
134MAPK100.39844692
135PRKCB0.39594255
136PRKACB0.39041876
137CDK180.38419090
138WNK10.38373136
139RET0.38246071
140CSNK1D0.37832522
141AURKA0.37677376
142CDK20.37316614
143NEK20.36666871
144DAPK30.36456509
145SGK10.35950523
146RPS6KA30.35504176
147CDK10.35479670
148PLK20.35258777
149GSK3B0.35161798
150CHEK20.35036714
151CHEK10.34918391
152ILK0.34909152
153FER0.34782113
154RPS6KA10.34464146
155PKN20.34255181
156FRK0.34187257
157WEE10.34121712
158PDGFRB0.34073855
159MAP2K10.34011219
160TGFBR10.33758702
161MAPK10.32247082
162BTK0.31419850
163WNK40.29862450
164BRSK10.27206350
165MKNK20.26135193
166TGFBR20.25082419
167MAPK140.25035728
168PRKACA0.24562507
169PAK10.24536587
170PRKCE0.23778965
171AURKB0.23052655

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.71689432
2* Olfactory transduction_Homo sapiens_hsa047406.23028252
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.49642223
4ECM-receptor interaction_Homo sapiens_hsa045122.79088772
5Synaptic vesicle cycle_Homo sapiens_hsa047212.49522159
6Morphine addiction_Homo sapiens_hsa050322.36483116
7GABAergic synapse_Homo sapiens_hsa047272.36224849
8Circadian entrainment_Homo sapiens_hsa047132.14163420
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99497315
10Butanoate metabolism_Homo sapiens_hsa006501.98614650
11Cholinergic synapse_Homo sapiens_hsa047251.98437017
12Platelet activation_Homo sapiens_hsa046111.96238562
13Dopaminergic synapse_Homo sapiens_hsa047281.93499851
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92592370
15Glutamatergic synapse_Homo sapiens_hsa047241.88118650
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74448242
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74101904
18Insulin secretion_Homo sapiens_hsa049111.58287277
19Adherens junction_Homo sapiens_hsa045201.57085847
20Taste transduction_Homo sapiens_hsa047421.52004435
21Fatty acid degradation_Homo sapiens_hsa000711.45544845
22Nicotine addiction_Homo sapiens_hsa050331.44189017
23Hedgehog signaling pathway_Homo sapiens_hsa043401.44011629
24Focal adhesion_Homo sapiens_hsa045101.38720461
25Salivary secretion_Homo sapiens_hsa049701.38033866
26Arginine and proline metabolism_Homo sapiens_hsa003301.35346096
27Systemic lupus erythematosus_Homo sapiens_hsa053221.31011374
28Serotonergic synapse_Homo sapiens_hsa047261.25724604
29Amphetamine addiction_Homo sapiens_hsa050311.24394795
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24327975
31cAMP signaling pathway_Homo sapiens_hsa040241.24186588
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22685953
33Adipocytokine signaling pathway_Homo sapiens_hsa049201.17671795
34Cocaine addiction_Homo sapiens_hsa050301.15610411
35RNA transport_Homo sapiens_hsa030131.14911760
36Gastric acid secretion_Homo sapiens_hsa049711.12528776
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12357096
38PPAR signaling pathway_Homo sapiens_hsa033201.11987578
39Oxytocin signaling pathway_Homo sapiens_hsa049211.06507990
40Renin secretion_Homo sapiens_hsa049241.05865170
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05731185
42Long-term potentiation_Homo sapiens_hsa047201.01367311
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00567763
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96830614
45Hippo signaling pathway_Homo sapiens_hsa043900.95311850
46Alcoholism_Homo sapiens_hsa050340.93766874
47Circadian rhythm_Homo sapiens_hsa047100.93186552
48Fatty acid metabolism_Homo sapiens_hsa012120.92820985
49Fanconi anemia pathway_Homo sapiens_hsa034600.92442117
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91857475
51GnRH signaling pathway_Homo sapiens_hsa049120.90887356
52Calcium signaling pathway_Homo sapiens_hsa040200.87152223
53Arginine biosynthesis_Homo sapiens_hsa002200.86901176
54Mismatch repair_Homo sapiens_hsa034300.84846706
55Basal cell carcinoma_Homo sapiens_hsa052170.82693907
56Phenylalanine metabolism_Homo sapiens_hsa003600.82576142
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82272816
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81994526
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79627084
60Ovarian steroidogenesis_Homo sapiens_hsa049130.79488697
61Thyroid hormone synthesis_Homo sapiens_hsa049180.77501289
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75845029
63Small cell lung cancer_Homo sapiens_hsa052220.72834652
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71525173
65Gap junction_Homo sapiens_hsa045400.71281407
66Protein digestion and absorption_Homo sapiens_hsa049740.70218199
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69739252
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.69607842
69Nitrogen metabolism_Homo sapiens_hsa009100.69016368
70Estrogen signaling pathway_Homo sapiens_hsa049150.68775152
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68186083
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67210931
73Endocytosis_Homo sapiens_hsa041440.66869362
74Biosynthesis of amino acids_Homo sapiens_hsa012300.66383720
75Retinol metabolism_Homo sapiens_hsa008300.66313799
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66268656
77Linoleic acid metabolism_Homo sapiens_hsa005910.65133455
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64917217
79Sulfur relay system_Homo sapiens_hsa041220.62721103
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.62657890
81Collecting duct acid secretion_Homo sapiens_hsa049660.62128148
82Bile secretion_Homo sapiens_hsa049760.61917287
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61821909
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59690089
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59229517
86Renin-angiotensin system_Homo sapiens_hsa046140.58909546
87Glioma_Homo sapiens_hsa052140.58405210
88Type II diabetes mellitus_Homo sapiens_hsa049300.58318842
89Tyrosine metabolism_Homo sapiens_hsa003500.57495487
90Selenocompound metabolism_Homo sapiens_hsa004500.56914372
91Lysine degradation_Homo sapiens_hsa003100.56497024
92Dilated cardiomyopathy_Homo sapiens_hsa054140.54917487
93TGF-beta signaling pathway_Homo sapiens_hsa043500.54469722
94Vibrio cholerae infection_Homo sapiens_hsa051100.54229288
95ABC transporters_Homo sapiens_hsa020100.54087624
96mTOR signaling pathway_Homo sapiens_hsa041500.53569950
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.53506096
98beta-Alanine metabolism_Homo sapiens_hsa004100.53248401
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52340707
100Oocyte meiosis_Homo sapiens_hsa041140.51609829
101Arachidonic acid metabolism_Homo sapiens_hsa005900.50913487
102Glucagon signaling pathway_Homo sapiens_hsa049220.50908863
103Fatty acid biosynthesis_Homo sapiens_hsa000610.50696700
104Cardiac muscle contraction_Homo sapiens_hsa042600.49657527
105Melanogenesis_Homo sapiens_hsa049160.48362307
106Pancreatic secretion_Homo sapiens_hsa049720.47492830
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.47208839
108Ras signaling pathway_Homo sapiens_hsa040140.46999231
109Fat digestion and absorption_Homo sapiens_hsa049750.46564434
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45779489
111Pathways in cancer_Homo sapiens_hsa052000.44202981
112Chemokine signaling pathway_Homo sapiens_hsa040620.44146064
113Inositol phosphate metabolism_Homo sapiens_hsa005620.43089839
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41458897
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.41159321
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41052580
117Endometrial cancer_Homo sapiens_hsa052130.40754888
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39278169
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39076905
120Axon guidance_Homo sapiens_hsa043600.37893086
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.37083133
122VEGF signaling pathway_Homo sapiens_hsa043700.36468443
123Choline metabolism in cancer_Homo sapiens_hsa052310.35914007
124Purine metabolism_Homo sapiens_hsa002300.35692776
125Colorectal cancer_Homo sapiens_hsa052100.34949345
126Non-small cell lung cancer_Homo sapiens_hsa052230.34949029
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33828490
128ErbB signaling pathway_Homo sapiens_hsa040120.31006281
129MAPK signaling pathway_Homo sapiens_hsa040100.26826996
130Rap1 signaling pathway_Homo sapiens_hsa040150.26821601
131Glycerolipid metabolism_Homo sapiens_hsa005610.26741459
132Renal cell carcinoma_Homo sapiens_hsa052110.26195510
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23639171
134Insulin signaling pathway_Homo sapiens_hsa049100.22651665
135Tight junction_Homo sapiens_hsa045300.21289092
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20232071
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18764722
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.18525150
139Chronic myeloid leukemia_Homo sapiens_hsa052200.18489424
140Regulation of autophagy_Homo sapiens_hsa041400.18036421
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18021629
142Pancreatic cancer_Homo sapiens_hsa052120.16788484
143Long-term depression_Homo sapiens_hsa047300.16526857
144Notch signaling pathway_Homo sapiens_hsa043300.15299710
145AMPK signaling pathway_Homo sapiens_hsa041520.13760594
146Dorso-ventral axis formation_Homo sapiens_hsa043200.13418473
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13014576

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