ANO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.77710517
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48282286
3L-amino acid import (GO:0043092)5.45486043
4locomotory exploration behavior (GO:0035641)5.37155488
5sodium ion export (GO:0071436)5.33197353
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.14978836
7synaptic vesicle maturation (GO:0016188)5.13946398
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12748803
9synaptic vesicle exocytosis (GO:0016079)5.11339952
10vocalization behavior (GO:0071625)5.04467484
11neuronal action potential propagation (GO:0019227)4.98741132
12regulation of glutamate receptor signaling pathway (GO:1900449)4.79881641
13regulation of synapse structural plasticity (GO:0051823)4.79462970
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77985000
15glutamate secretion (GO:0014047)4.70899119
16protein localization to synapse (GO:0035418)4.69855277
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.69531901
18amino acid import (GO:0043090)4.65873869
19regulation of synaptic vesicle exocytosis (GO:2000300)4.65611612
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.56496730
21neurotransmitter-gated ion channel clustering (GO:0072578)4.49465617
22regulation of neuronal synaptic plasticity (GO:0048168)4.45197351
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.43469373
24neuron-neuron synaptic transmission (GO:0007270)4.40795741
25synaptic transmission, glutamatergic (GO:0035249)4.30150795
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24313431
27glutamate receptor signaling pathway (GO:0007215)4.22258570
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.18873216
29regulation of synaptic vesicle transport (GO:1902803)4.18497028
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.15506958
31exploration behavior (GO:0035640)4.11996400
32neuron cell-cell adhesion (GO:0007158)4.11152706
33negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.11084577
34axon ensheathment in central nervous system (GO:0032291)4.10811327
35central nervous system myelination (GO:0022010)4.10811327
36synaptic transmission, dopaminergic (GO:0001963)4.01838606
37prepulse inhibition (GO:0060134)4.00989545
38positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.98171189
39cerebellar granule cell differentiation (GO:0021707)3.97996242
40neurotransmitter secretion (GO:0007269)3.94270148
41regulation of dendritic spine morphogenesis (GO:0061001)3.92043807
42regulation of postsynaptic membrane potential (GO:0060078)3.91556051
43striatum development (GO:0021756)3.88449827
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.86095697
45regulation of synaptic plasticity (GO:0048167)3.86083593
46positive regulation of membrane potential (GO:0045838)3.85989037
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.85681144
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84136027
49long-term synaptic potentiation (GO:0060291)3.82011029
50positive regulation of neurotransmitter transport (GO:0051590)3.77049463
51behavioral response to cocaine (GO:0048148)3.76903824
52negative regulation of dendrite morphogenesis (GO:0050774)3.76327964
53long-term memory (GO:0007616)3.73634183
54positive regulation of neurotransmitter secretion (GO:0001956)3.73412918
55potassium ion homeostasis (GO:0055075)3.72118571
56regulation of neurotransmitter levels (GO:0001505)3.70490509
57serotonin metabolic process (GO:0042428)3.67877830
58postsynaptic membrane organization (GO:0001941)3.67847809
59positive regulation of dendritic spine development (GO:0060999)3.66918443
60potassium ion import (GO:0010107)3.66228572
61neuromuscular process controlling balance (GO:0050885)3.65616585
62response to histamine (GO:0034776)3.65411388
63negative regulation of dendrite development (GO:2000171)3.64835860
64auditory behavior (GO:0031223)3.61797617
65synaptic vesicle endocytosis (GO:0048488)3.58600594
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.57744188
67cell communication by electrical coupling (GO:0010644)3.56643354
68membrane depolarization during action potential (GO:0086010)3.56112042
69cellular sodium ion homeostasis (GO:0006883)3.52312380
70behavioral defense response (GO:0002209)3.51618222
71behavioral fear response (GO:0001662)3.51618222
72adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.51017679
73regulation of glutamate secretion (GO:0014048)3.49621085
74response to amphetamine (GO:0001975)3.48043449
75membrane depolarization (GO:0051899)3.46486294
76transmission of nerve impulse (GO:0019226)3.45442172
77neurotransmitter uptake (GO:0001504)3.44297141
78dendritic spine morphogenesis (GO:0060997)3.43014027
79acidic amino acid transport (GO:0015800)3.37215549
80detection of calcium ion (GO:0005513)3.35292353
81regulation of voltage-gated calcium channel activity (GO:1901385)3.35045167
82cellular potassium ion homeostasis (GO:0030007)3.34694595
83activation of protein kinase A activity (GO:0034199)3.31995289
84presynaptic membrane assembly (GO:0097105)3.31401638
85positive regulation of synapse maturation (GO:0090129)3.30329153
86regulation of neurotransmitter secretion (GO:0046928)3.29711724
87response to auditory stimulus (GO:0010996)3.29232482
88gamma-aminobutyric acid transport (GO:0015812)3.28343522
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27814079
90membrane hyperpolarization (GO:0060081)3.26506171
91positive regulation of dendritic spine morphogenesis (GO:0061003)3.26398585
92regulation of dendritic spine development (GO:0060998)3.25698801
93regulation of protein kinase A signaling (GO:0010738)3.23151373
94layer formation in cerebral cortex (GO:0021819)3.22924487
95primary amino compound metabolic process (GO:1901160)3.22869488
96neuronal action potential (GO:0019228)3.22656961
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.21493144
98positive regulation of synaptic transmission (GO:0050806)3.21252872
99fear response (GO:0042596)3.21050478
100gamma-aminobutyric acid signaling pathway (GO:0007214)3.20870089
101regulation of neurotransmitter transport (GO:0051588)3.19343444
102dopamine receptor signaling pathway (GO:0007212)3.18361750
103adenosine receptor signaling pathway (GO:0001973)3.17820606
104startle response (GO:0001964)3.17743390
105learning (GO:0007612)3.14855883
106regulation of synaptic transmission (GO:0050804)3.14566073
107negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14137458
108regulation of female receptivity (GO:0045924)3.13565554
109cAMP catabolic process (GO:0006198)3.12893068
110synaptic transmission (GO:0007268)3.12740089
111proline transport (GO:0015824)3.10973705
112presynaptic membrane organization (GO:0097090)3.10952369
113neuromuscular process (GO:0050905)3.10945485
114neurotransmitter transport (GO:0006836)3.10760520
115cerebellar Purkinje cell differentiation (GO:0021702)3.10720462
116visual learning (GO:0008542)3.10377227
117regulation of vesicle fusion (GO:0031338)3.08983935
118long term synaptic depression (GO:0060292)3.08645945
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08286510
120vesicle transport along microtubule (GO:0047496)3.08081721
121regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.06780274
122regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.06780274
123vesicle docking involved in exocytosis (GO:0006904)3.06137108
124L-glutamate transport (GO:0015813)3.05857176
125mechanosensory behavior (GO:0007638)3.05085919
126neuronal ion channel clustering (GO:0045161)3.04755339
127cell communication involved in cardiac conduction (GO:0086065)3.04283678
128regulation of ARF protein signal transduction (GO:0032012)3.04042911
129regulation of synapse maturation (GO:0090128)3.03616670
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03541498
131phosphorelay signal transduction system (GO:0000160)2.96783360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.68140736
2GBX2_23144817_ChIP-Seq_PC3_Human4.00258575
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24760215
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14397397
5RARB_27405468_Chip-Seq_BRAIN_Mouse3.14160074
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07733176
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75594957
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75594957
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73637043
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67671559
11REST_21632747_ChIP-Seq_MESCs_Mouse2.63247538
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55221890
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52899213
14DROSHA_22980978_ChIP-Seq_HELA_Human2.50495533
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47935631
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.45627108
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41955354
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22381070
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.20574171
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.15218098
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14628338
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.14112556
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11392264
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.09946739
25TAF15_26573619_Chip-Seq_HEK293_Human1.99579357
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98557471
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87061483
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81284297
29SMAD4_21799915_ChIP-Seq_A2780_Human1.78185205
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74961595
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69837084
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68392111
33* AR_21572438_ChIP-Seq_LNCaP_Human1.58298410
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57949155
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.56697272
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50646682
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50545541
38P300_19829295_ChIP-Seq_ESCs_Human1.50150550
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48539266
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45432994
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41484212
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.40837537
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38430210
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.36016395
45SOX2_21211035_ChIP-Seq_LN229_Gbm1.35660941
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34429100
47* STAT3_23295773_ChIP-Seq_U87_Human1.31452789
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29915429
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28850904
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27051822
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26290330
52* AR_25329375_ChIP-Seq_VCAP_Human1.25419616
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23803016
54AR_19668381_ChIP-Seq_PC3_Human1.23323083
55P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22906728
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20697709
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19838277
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.19616315
59TP53_16413492_ChIP-PET_HCT116_Human1.19453381
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19192737
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18255981
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.17831582
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16727074
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15106253
65ZNF274_21170338_ChIP-Seq_K562_Hela1.15005302
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14719878
67* TCF4_23295773_ChIP-Seq_U87_Human1.14439652
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14037083
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.12825986
70AHR_22903824_ChIP-Seq_MCF-7_Human1.12376836
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.10311897
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08553869
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08382006
74* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07618070
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.07345073
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06411740
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.06367184
78YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05985570
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04618925
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.04592464
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04456715
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.04326199
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04074344
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02717828
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02129515
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02077424
87RXR_22108803_ChIP-Seq_LS180_Human1.01588040
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00723007
89RUNX2_22187159_ChIP-Seq_PCA_Human1.00700109
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00665063
91RNF2_27304074_Chip-Seq_NSC_Mouse0.98009559
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96054711
93FUS_26573619_Chip-Seq_HEK293_Human0.95010866
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94750658
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94685693
96KDM2B_26808549_Chip-Seq_K562_Human0.93542189
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92954340
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.92936224
99TP53_18474530_ChIP-ChIP_U2OS_Human0.92862407
100JUN_21703547_ChIP-Seq_K562_Human0.92858265
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.92407272
102SOX9_26525672_Chip-Seq_HEART_Mouse0.91764820
103* BCAT_22108803_ChIP-Seq_LS180_Human0.91122439
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90896639
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.90547805
106GATA1_26923725_Chip-Seq_HPCs_Mouse0.89764896
107ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89601316
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89515570
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89047139
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88256644
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87455150
112* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87177492
113KDM2B_26808549_Chip-Seq_REH_Human0.86782024
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.86651047
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86057429
116* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84300415
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83137359

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.62280509
2MP0002822_catalepsy5.34139004
3MP0003880_abnormal_central_pattern5.10891820
4MP0003635_abnormal_synaptic_transmissio4.20056067
5MP0004270_analgesia3.86601140
6MP0001968_abnormal_touch/_nociception3.84042390
7MP0009745_abnormal_behavioral_response3.63343151
8MP0002063_abnormal_learning/memory/cond3.46934682
9MP0002064_seizures3.18873781
10MP0002736_abnormal_nociception_after3.15757899
11MP0009046_muscle_twitch3.04457090
12MP0002572_abnormal_emotion/affect_behav2.86927942
13MP0002735_abnormal_chemical_nociception2.83910364
14MP0002272_abnormal_nervous_system2.72813978
15MP0002734_abnormal_mechanical_nocicepti2.68530326
16MP0001486_abnormal_startle_reflex2.57480217
17MP0002733_abnormal_thermal_nociception2.25067369
18MP0001501_abnormal_sleep_pattern2.17739776
19MP0001970_abnormal_pain_threshold2.16316560
20MP0005423_abnormal_somatic_nervous2.11243554
21MP0002067_abnormal_sensory_capabilities1.99386025
22MP0001440_abnormal_grooming_behavior1.89401829
23MP0002909_abnormal_adrenal_gland1.80497013
24MP0001529_abnormal_vocalization1.79227674
25MP0004924_abnormal_behavior1.77519383
26MP0005386_behavior/neurological_phenoty1.77519383
27MP0008569_lethality_at_weaning1.75394138
28MP0004811_abnormal_neuron_physiology1.75108948
29MP0005646_abnormal_pituitary_gland1.73196690
30MP0009780_abnormal_chondrocyte_physiolo1.72466570
31MP0003879_abnormal_hair_cell1.68626272
32MP0004858_abnormal_nervous_system1.65314954
33MP0002184_abnormal_innervation1.59573655
34MP0001984_abnormal_olfaction1.59067005
35MP0002557_abnormal_social/conspecific_i1.57206522
36MP0003329_amyloid_beta_deposits1.50968982
37MP0001188_hyperpigmentation1.44900718
38MP0000955_abnormal_spinal_cord1.41081494
39MP0000778_abnormal_nervous_system1.39520980
40MP0003633_abnormal_nervous_system1.38286496
41MP0002066_abnormal_motor_capabilities/c1.35091902
42MP0006276_abnormal_autonomic_nervous1.33791030
43MP0002882_abnormal_neuron_morphology1.26613901
44MP0008874_decreased_physiological_sensi1.21400230
45MP0001905_abnormal_dopamine_level1.18628587
46MP0003787_abnormal_imprinting1.14364612
47MP0003631_nervous_system_phenotype1.10920857
48MP0000569_abnormal_digit_pigmentation1.10744028
49MP0004885_abnormal_endolymph1.09691058
50MP0008872_abnormal_physiological_respon1.08117754
51MP0005409_darkened_coat_color1.05247073
52MP0010234_abnormal_vibrissa_follicle1.03344677
53MP0002638_abnormal_pupillary_reflex1.01865231
54MP0003075_altered_response_to0.99809574
55MP0004142_abnormal_muscle_tone0.98800716
56MP0001502_abnormal_circadian_rhythm0.96115317
57MP0001177_atelectasis0.94015520
58MP0000751_myopathy0.93768907
59MP0001348_abnormal_lacrimal_gland0.92690614
60MP0002152_abnormal_brain_morphology0.92493362
61MP0004130_abnormal_muscle_cell0.92324322
62MP0004085_abnormal_heartbeat0.90899782
63MP0000013_abnormal_adipose_tissue0.87369723
64MP0001346_abnormal_lacrimal_gland0.87137125
65MP0002069_abnormal_eating/drinking_beha0.86247434
66MP0004147_increased_porphyrin_level0.85123418
67MP0002229_neurodegeneration0.82935109
68MP0005171_absent_coat_pigmentation0.82843011
69MP0004145_abnormal_muscle_electrophysio0.78077779
70MP0003123_paternal_imprinting0.77887699
71MP0003283_abnormal_digestive_organ0.75991259
72MP0005645_abnormal_hypothalamus_physiol0.75452712
73MP0005535_abnormal_body_temperature0.74829427
74MP0000920_abnormal_myelination0.72616670
75MP0005670_abnormal_white_adipose0.70096526
76MP0004742_abnormal_vestibular_system0.69981711
77MP0003868_abnormal_feces_composition0.66532073
78MP0008961_abnormal_basal_metabolism0.66205801
79MP0003634_abnormal_glial_cell0.66112532
80MP0010030_abnormal_orbit_morphology0.66092751
81MP0001963_abnormal_hearing_physiology0.66009501
82MP0005167_abnormal_blood-brain_barrier0.65037938
83MP0000604_amyloidosis0.64879184
84MP0001664_abnormal_digestion0.64839781
85MP0010386_abnormal_urinary_bladder0.64789688
86MP0001485_abnormal_pinna_reflex0.64550007
87MP0002090_abnormal_vision0.63494280
88MP0003690_abnormal_glial_cell0.63269694
89MP0003632_abnormal_nervous_system0.62388677
90MP0002837_dystrophic_cardiac_calcinosis0.61370427
91MP0004215_abnormal_myocardial_fiber0.61306013
92MP0005551_abnormal_eye_electrophysiolog0.59756972
93MP0003122_maternal_imprinting0.59732518
94MP0002752_abnormal_somatic_nervous0.58754673
95MP0004484_altered_response_of0.57511402
96MP0003137_abnormal_impulse_conducting0.56678440
97MP0005499_abnormal_olfactory_system0.56140135
98MP0005394_taste/olfaction_phenotype0.56140135
99MP0005623_abnormal_meninges_morphology0.54303714
100MP0000631_abnormal_neuroendocrine_gland0.53738699
101MP0002876_abnormal_thyroid_physiology0.53477379
102MP0000026_abnormal_inner_ear0.50953806
103MP0001943_abnormal_respiration0.50333901
104MP0003045_fibrosis0.50333630
105MP0001299_abnormal_eye_distance/0.49780850
106MP0010769_abnormal_survival0.49386338
107MP0003183_abnormal_peptide_metabolism0.49041463
108MP0001958_emphysema0.48803062
109MP0004043_abnormal_pH_regulation0.48332863
110MP0005595_abnormal_vascular_smooth0.48297049
111MP0004510_myositis0.48196923
112MP0004233_abnormal_muscle_weight0.47591617
113MP0010770_preweaning_lethality0.46132243
114MP0002082_postnatal_lethality0.46132243
115MP0003956_abnormal_body_size0.45829308
116MP0010768_mortality/aging0.45398356
117MP0008877_abnormal_DNA_methylation0.45026156
118MP0000579_abnormal_nail_morphology0.44086246
119MP0001765_abnormal_ion_homeostasis0.43926815
120MP0002295_abnormal_pulmonary_circulatio0.43493182

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.05256729
2Myokymia (HP:0002411)8.33150213
3Focal seizures (HP:0007359)6.50089280
4Epileptic encephalopathy (HP:0200134)4.96750525
5Atonic seizures (HP:0010819)4.96173988
6Febrile seizures (HP:0002373)4.91970802
7Visual hallucinations (HP:0002367)4.51991890
8Absence seizures (HP:0002121)4.42748884
9Action tremor (HP:0002345)4.35231042
10Dialeptic seizures (HP:0011146)4.23792148
11Neurofibrillary tangles (HP:0002185)4.05741610
12Generalized tonic-clonic seizures (HP:0002069)4.04888654
13Progressive cerebellar ataxia (HP:0002073)3.91421868
14Gaze-evoked nystagmus (HP:0000640)3.88740271
15Poor eye contact (HP:0000817)3.81830168
16Impaired vibration sensation in the lower limbs (HP:0002166)3.76976996
17Broad-based gait (HP:0002136)3.76096036
18Hyperventilation (HP:0002883)3.58889502
19Impaired social interactions (HP:0000735)3.40215834
20Abnormal social behavior (HP:0012433)3.40215834
21Dysdiadochokinesis (HP:0002075)3.39526373
22Truncal ataxia (HP:0002078)3.32233242
23Resting tremor (HP:0002322)3.27998288
24Depression (HP:0000716)3.26714528
25Dysmetric saccades (HP:0000641)3.25331943
26Annular pancreas (HP:0001734)3.23884714
27Ankle clonus (HP:0011448)3.22447981
28Urinary bladder sphincter dysfunction (HP:0002839)3.17423944
29Anxiety (HP:0000739)3.15954896
30Scanning speech (HP:0002168)3.15942187
31Dysmetria (HP:0001310)3.15614017
32Amblyopia (HP:0000646)3.14459308
33Insidious onset (HP:0003587)2.95028388
34Termporal pattern (HP:0011008)2.95028388
35Urinary urgency (HP:0000012)2.93014338
36Impaired smooth pursuit (HP:0007772)2.88041339
37Postural instability (HP:0002172)2.79886292
38Supranuclear gaze palsy (HP:0000605)2.79507044
39Stereotypic behavior (HP:0000733)2.78181686
40Abnormal eating behavior (HP:0100738)2.73405014
41Tetraplegia (HP:0002445)2.71215860
42Impaired vibratory sensation (HP:0002495)2.70123506
43Abnormality of the lower motor neuron (HP:0002366)2.65075156
44Neuronal loss in central nervous system (HP:0002529)2.57062524
45Spastic tetraparesis (HP:0001285)2.56111926
46Spastic gait (HP:0002064)2.49750748
47Cerebral hypomyelination (HP:0006808)2.47373361
48Epileptiform EEG discharges (HP:0011182)2.45836035
49* Torticollis (HP:0000473)2.45016206
50Abnormality of ocular smooth pursuit (HP:0000617)2.43531911
51Bradykinesia (HP:0002067)2.42413470
52Delusions (HP:0000746)2.42298355
53Excessive salivation (HP:0003781)2.40490407
54Drooling (HP:0002307)2.40490407
55Lower limb amyotrophy (HP:0007210)2.39804277
56Papilledema (HP:0001085)2.36451669
57Ankyloglossia (HP:0010296)2.36195726
58Pointed chin (HP:0000307)2.31666694
59Status epilepticus (HP:0002133)2.31577303
60Pheochromocytoma (HP:0002666)2.30283590
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.29597137
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29597137
63* Focal dystonia (HP:0004373)2.29106703
64Fetal akinesia sequence (HP:0001989)2.27190416
65Absent speech (HP:0001344)2.22279773
66Intention tremor (HP:0002080)2.21812249
67Apathy (HP:0000741)2.21623015
68EEG with generalized epileptiform discharges (HP:0011198)2.21431949
69Blue irides (HP:0000635)2.18407011
70Genetic anticipation (HP:0003743)2.14981005
71Akinesia (HP:0002304)2.14668413
72Bronchomalacia (HP:0002780)2.09122520
73Inability to walk (HP:0002540)2.08542250
74Lower limb muscle weakness (HP:0007340)2.07731950
75Ventricular fibrillation (HP:0001663)2.07069611
76Hemiparesis (HP:0001269)2.06700880
77Progressive inability to walk (HP:0002505)2.06681427
78Hypsarrhythmia (HP:0002521)2.05941153
79Lower limb asymmetry (HP:0100559)2.05665792
80Gait ataxia (HP:0002066)2.05226198
81Sleep apnea (HP:0010535)2.02589165
82Prolonged QT interval (HP:0001657)2.02577264
83Abnormal EKG (HP:0003115)2.02315558
84Abnormality of pain sensation (HP:0010832)2.01782449
85Impaired pain sensation (HP:0007328)2.01782449
86Neuroendocrine neoplasm (HP:0100634)2.01430466
87* Craniofacial dystonia (HP:0012179)2.01269571
88* Incomplete penetrance (HP:0003829)1.99352756
89Peripheral hypomyelination (HP:0007182)1.99134677
90Aplasia involving bones of the upper limbs (HP:0009823)1.98990283
91Aplasia of the phalanges of the hand (HP:0009802)1.98990283
92Aplasia involving bones of the extremities (HP:0009825)1.98990283
93Distal lower limb amyotrophy (HP:0008944)1.98783299
94Split foot (HP:0001839)1.98709368
95Protruding tongue (HP:0010808)1.94533729
96Megalencephaly (HP:0001355)1.94206120
97Polyphagia (HP:0002591)1.93943426
98Generalized myoclonic seizures (HP:0002123)1.93372866
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92735247
100Mutism (HP:0002300)1.92473080
101Diminished motivation (HP:0000745)1.90990118
102Morphological abnormality of the pyramidal tract (HP:0002062)1.90823650
103Abnormality of the corticospinal tract (HP:0002492)1.90804258
104Rapidly progressive (HP:0003678)1.89393008
105CNS hypomyelination (HP:0003429)1.88633768
106Insomnia (HP:0100785)1.88568843
107Hammertoe (HP:0001765)1.88429973
108Hemiplegia (HP:0002301)1.88353393
109Increased circulating renin level (HP:0000848)1.87420371
110Bundle branch block (HP:0011710)1.84728442
111Spinal canal stenosis (HP:0003416)1.83530617
112Abnormality of saccadic eye movements (HP:0000570)1.82995862
113Deeply set eye (HP:0000490)1.82074193
114Cerebral inclusion bodies (HP:0100314)1.82006871
115Diplopia (HP:0000651)1.80700290
116Abnormality of binocular vision (HP:0011514)1.80700290
117Limb dystonia (HP:0002451)1.79873177
118Clonus (HP:0002169)1.79030139
119Generalized hypopigmentation of hair (HP:0011358)1.77868832
120Atrioventricular block (HP:0001678)1.76364116
121Obstructive sleep apnea (HP:0002870)1.75038375
122Ulnar claw (HP:0001178)1.73428309
123Heart block (HP:0012722)1.72951031
124Neoplasm of the peripheral nervous system (HP:0100007)1.71951951
125Abnormality of oral frenula (HP:0000190)1.70914718
126Rigidity (HP:0002063)1.70141064
127Coronal craniosynostosis (HP:0004440)1.66926184
128Memory impairment (HP:0002354)1.64020854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.15909326
2NTRK34.88557557
3MAP3K93.49579128
4RIPK43.03736247
5DAPK22.88726028
6MAP3K42.61099545
7KSR22.60452711
8MINK12.38689794
9CASK2.30265039
10MAP2K72.23859382
11CAMKK12.04040195
12DAPK11.98202510
13MAP3K121.94431431
14PRKD31.85420187
15TNIK1.84662925
16PAK61.83310850
17ARAF1.81466155
18CAMKK21.80731566
19KSR11.78538325
20NTRK11.77578589
21PRPF4B1.72000612
22MAP2K41.69084873
23CDK191.62655754
24MAP3K21.54009059
25CDK51.44716227
26MAP3K131.44175599
27NTRK21.37663014
28PLK21.34932774
29FES1.30981487
30MARK11.28284738
31GRK51.24058186
32TAOK11.17813760
33PTK2B1.17668996
34BMPR21.12782529
35RAF11.11641752
36SGK2231.07853838
37SGK4941.07853838
38SGK21.06988817
39STK381.05774728
40PRKCG1.05121748
41SIK21.03122568
42MAPK131.01856797
43CAMK2A0.97138625
44RET0.93950016
45RIPK10.90360761
46CAMK2B0.88055940
47TYRO30.85988789
48CDK180.85680855
49SIK30.84657183
50SGK30.84448440
51OXSR10.84201908
52CDK140.81612528
53CDK150.80365259
54CAMK10.79060568
55PDK10.78525377
56PDPK10.76658433
57MAP3K10.74982694
58SGK10.74795427
59LMTK20.72274465
60PINK10.72052148
61STK110.71861152
62PRKCH0.71359923
63CCNB10.70569485
64AKT30.69346540
65MAP2K10.68902546
66CDK11A0.68575520
67UHMK10.67290282
68MAPK120.65829065
69PKN10.62774364
70BRAF0.58746333
71MARK20.57454116
72DAPK30.55424117
73PNCK0.53272811
74NEK10.52106778
75TNK20.51474281
76CAMK40.48649254
77FER0.48285634
78MAP3K110.46542315
79WNK10.46021410
80FGR0.45706558
81LATS20.44507339
82CAMK2D0.44494884
83RPS6KA30.44344266
84NEK60.43721949
85PRKCE0.41993635
86PAK30.40706746
87CAMK2G0.40035825
88ROCK20.39323199
89PRKG10.39187212
90PRKCZ0.38836869
91FGFR20.38778077
92SCYL20.38666482
93FYN0.38482810
94MAPK100.37179261
95CAMK1G0.37168422
96PDGFRA0.36820851
97MOS0.34272250
98DDR20.33898686
99PHKG10.32558908
100PHKG20.32558908
101LIMK10.32535826
102CDC42BPA0.31145204
103PRKCB0.30968939
104DYRK1A0.30279243
105CSNK1D0.28873302
106ALK0.28867967
107BCR0.28764073
108STK390.28505447
109BRSK10.27408664
110CSNK1A10.26949496
111CSNK1E0.26607199
112PRKCA0.26240583
113PRKACA0.25908070
114CSNK1G20.25473972

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.45583414
2Olfactory transduction_Homo sapiens_hsa047403.24658916
3Synaptic vesicle cycle_Homo sapiens_hsa047213.11824839
4Long-term potentiation_Homo sapiens_hsa047202.91395162
5Amphetamine addiction_Homo sapiens_hsa050312.79071925
6Circadian entrainment_Homo sapiens_hsa047132.77130344
7Morphine addiction_Homo sapiens_hsa050322.66281516
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59294861
9Glutamatergic synapse_Homo sapiens_hsa047242.58125875
10GABAergic synapse_Homo sapiens_hsa047272.45972278
11Dopaminergic synapse_Homo sapiens_hsa047282.31643548
12Salivary secretion_Homo sapiens_hsa049702.22858356
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04748603
14Cholinergic synapse_Homo sapiens_hsa047251.97685881
15Insulin secretion_Homo sapiens_hsa049111.92526583
16Renin secretion_Homo sapiens_hsa049241.91455608
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86315189
18Cocaine addiction_Homo sapiens_hsa050301.85512989
19Gastric acid secretion_Homo sapiens_hsa049711.82838106
20Taste transduction_Homo sapiens_hsa047421.78954095
21Oxytocin signaling pathway_Homo sapiens_hsa049211.76582352
22Calcium signaling pathway_Homo sapiens_hsa040201.75804032
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68541257
24Long-term depression_Homo sapiens_hsa047301.65231096
25Serotonergic synapse_Homo sapiens_hsa047261.61932239
26GnRH signaling pathway_Homo sapiens_hsa049121.50549827
27Collecting duct acid secretion_Homo sapiens_hsa049661.48648260
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44014673
29Vitamin B6 metabolism_Homo sapiens_hsa007501.43482291
30Gap junction_Homo sapiens_hsa045401.42975127
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41004242
32cAMP signaling pathway_Homo sapiens_hsa040241.34142471
33Glioma_Homo sapiens_hsa052141.26670487
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26048218
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23627248
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08070387
37Estrogen signaling pathway_Homo sapiens_hsa049151.06646505
38ErbB signaling pathway_Homo sapiens_hsa040121.06137327
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05763573
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05046672
41Type II diabetes mellitus_Homo sapiens_hsa049301.04786956
42Melanogenesis_Homo sapiens_hsa049161.04116664
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.02729529
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00658213
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00582500
46Axon guidance_Homo sapiens_hsa043600.93600157
47Histidine metabolism_Homo sapiens_hsa003400.92982837
48Oocyte meiosis_Homo sapiens_hsa041140.90580201
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.88207057
50Vibrio cholerae infection_Homo sapiens_hsa051100.86950645
51Pancreatic secretion_Homo sapiens_hsa049720.85317051
52Cardiac muscle contraction_Homo sapiens_hsa042600.84926665
53Phototransduction_Homo sapiens_hsa047440.83427807
54Fatty acid biosynthesis_Homo sapiens_hsa000610.81972727
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81293152
56VEGF signaling pathway_Homo sapiens_hsa043700.77729864
57Nitrogen metabolism_Homo sapiens_hsa009100.75547597
58Thyroid hormone synthesis_Homo sapiens_hsa049180.75370136
59Choline metabolism in cancer_Homo sapiens_hsa052310.73745473
60Dilated cardiomyopathy_Homo sapiens_hsa054140.72351770
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71102577
62MAPK signaling pathway_Homo sapiens_hsa040100.70379377
63Rap1 signaling pathway_Homo sapiens_hsa040150.69768591
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.69237658
65beta-Alanine metabolism_Homo sapiens_hsa004100.67884225
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66438496
67Arginine biosynthesis_Homo sapiens_hsa002200.63576108
68Non-small cell lung cancer_Homo sapiens_hsa052230.61226129
69Ras signaling pathway_Homo sapiens_hsa040140.59194041
70Glucagon signaling pathway_Homo sapiens_hsa049220.58136188
71Alcoholism_Homo sapiens_hsa050340.57737642
72mTOR signaling pathway_Homo sapiens_hsa041500.57256438
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54129140
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.53584800
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53459012
76African trypanosomiasis_Homo sapiens_hsa051430.52162284
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51930267
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50439159
79Inositol phosphate metabolism_Homo sapiens_hsa005620.47937086
80Arginine and proline metabolism_Homo sapiens_hsa003300.47095877
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46367806
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45406555
83Circadian rhythm_Homo sapiens_hsa047100.43937509
84Endocytosis_Homo sapiens_hsa041440.42737474
85Mineral absorption_Homo sapiens_hsa049780.42452707
86Endometrial cancer_Homo sapiens_hsa052130.42373430
87Chemokine signaling pathway_Homo sapiens_hsa040620.39279463
88Bile secretion_Homo sapiens_hsa049760.39245041
89Prion diseases_Homo sapiens_hsa050200.38528329
90Glycerolipid metabolism_Homo sapiens_hsa005610.38143834
91Insulin signaling pathway_Homo sapiens_hsa049100.37635627
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37378939
93Type I diabetes mellitus_Homo sapiens_hsa049400.36492269
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36487895
95PPAR signaling pathway_Homo sapiens_hsa033200.35936399
96Wnt signaling pathway_Homo sapiens_hsa043100.35649509
97Ovarian steroidogenesis_Homo sapiens_hsa049130.35254059
98Hippo signaling pathway_Homo sapiens_hsa043900.33324004
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32988076
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32475324
101Tight junction_Homo sapiens_hsa045300.32312935
102Renal cell carcinoma_Homo sapiens_hsa052110.31189596
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30802177
104Alzheimers disease_Homo sapiens_hsa050100.30795575
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30667824
106Platelet activation_Homo sapiens_hsa046110.28951527
107Thyroid cancer_Homo sapiens_hsa052160.28659585
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28199555
109ABC transporters_Homo sapiens_hsa020100.27403130
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26965940
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26838517
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25512246
113Phenylalanine metabolism_Homo sapiens_hsa003600.24849693
114Melanoma_Homo sapiens_hsa052180.24567363
115Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21050551
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20026257

Most similar genes based on co-expression Upload to Enrichr

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