ANO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.44898990
2central nervous system myelination (GO:0022010)8.44898990
3myelination (GO:0042552)5.60658103
4ensheathment of neurons (GO:0007272)5.56512206
5axon ensheathment (GO:0008366)5.56512206
6fatty acid elongation (GO:0030497)5.51633010
7long-chain fatty acid biosynthetic process (GO:0042759)5.21689949
8presynaptic membrane assembly (GO:0097105)5.14145435
9presynaptic membrane organization (GO:0097090)5.01149467
10negative regulation of neurotransmitter secretion (GO:0046929)4.69484157
11glycerophospholipid catabolic process (GO:0046475)4.36161124
12neuron cell-cell adhesion (GO:0007158)4.25828079
13negative regulation of neurotransmitter transport (GO:0051589)4.18738078
14response to redox state (GO:0051775)4.18628265
15L-amino acid import (GO:0043092)4.16687761
16oligodendrocyte differentiation (GO:0048709)4.08032994
17short-term memory (GO:0007614)4.02724210
18positive regulation of dendritic spine morphogenesis (GO:0061003)3.95621902
19positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.93806284
20neuronal action potential propagation (GO:0019227)3.90383288
21photoreceptor cell differentiation (GO:0046530)3.79389038
22eye photoreceptor cell differentiation (GO:0001754)3.79389038
23negative regulation of protein localization to cell surface (GO:2000009)3.74769490
24transmission of nerve impulse (GO:0019226)3.73224903
25C4-dicarboxylate transport (GO:0015740)3.65240334
26positive regulation of action potential (GO:0045760)3.63531028
27cerebral cortex radially oriented cell migration (GO:0021799)3.58141681
28adult walking behavior (GO:0007628)3.54040666
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47215061
30establishment of mitochondrion localization (GO:0051654)3.45199816
31regulation of collateral sprouting (GO:0048670)3.42003992
32cerebellar Purkinje cell differentiation (GO:0021702)3.38496044
33negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.36089521
34apical protein localization (GO:0045176)3.27020231
35myelin maintenance (GO:0043217)3.25955703
36cholesterol biosynthetic process (GO:0006695)3.23931479
37astrocyte development (GO:0014002)3.23230397
38cellular response to epinephrine stimulus (GO:0071872)3.21611101
39myelination in peripheral nervous system (GO:0022011)3.21426497
40peripheral nervous system axon ensheathment (GO:0032292)3.21426497
41peptidyl-tyrosine autophosphorylation (GO:0038083)3.19133195
42glutamate secretion (GO:0014047)3.18630745
43asymmetric protein localization (GO:0008105)3.14524997
44positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.13867334
45import into cell (GO:0098657)3.11171986
46retinal cone cell development (GO:0046549)3.10369972
47neuronal ion channel clustering (GO:0045161)3.09902080
48substantia nigra development (GO:0021762)3.09401917
49cellular potassium ion homeostasis (GO:0030007)3.09353015
50membrane assembly (GO:0071709)3.07626898
51cerebellar Purkinje cell layer development (GO:0021680)3.07257526
52amino acid import (GO:0043090)3.07235588
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05907447
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.99313350
55cyclic nucleotide catabolic process (GO:0009214)2.98445916
56regulation of dendritic spine morphogenesis (GO:0061001)2.95806808
57positive regulation of dendritic spine development (GO:0060999)2.94876531
58axon extension (GO:0048675)2.94777335
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.93751639
60response to epinephrine (GO:0071871)2.89436914
61adhesion of symbiont to host cell (GO:0044650)2.87833558
62virion attachment to host cell (GO:0019062)2.87833558
63synaptic vesicle maturation (GO:0016188)2.87632968
64negative regulation of axonogenesis (GO:0050771)2.87224063
65negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87085045
66urinary tract smooth muscle contraction (GO:0014848)2.86827201
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86409290
68limb bud formation (GO:0060174)2.84823728
69behavioral response to cocaine (GO:0048148)2.83946599
70sterol biosynthetic process (GO:0016126)2.81418122
71regulation of synaptic transmission, GABAergic (GO:0032228)2.78774732
72cerebellar granule cell differentiation (GO:0021707)2.78289258
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.77855353
74layer formation in cerebral cortex (GO:0021819)2.76954070
75synaptic transmission, glutamatergic (GO:0035249)2.75649384
76isoprenoid biosynthetic process (GO:0008299)2.74712360
77neurotransmitter-gated ion channel clustering (GO:0072578)2.73894397
78neuron projection extension (GO:1990138)2.73867207
79gamma-aminobutyric acid transport (GO:0015812)2.73758534
80gamma-aminobutyric acid signaling pathway (GO:0007214)2.73057522
81cellular response to monoamine stimulus (GO:0071868)2.72753836
82cellular response to catecholamine stimulus (GO:0071870)2.72753836
83dendrite morphogenesis (GO:0048813)2.72746014
84positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.72368194
85prepulse inhibition (GO:0060134)2.71457488
86cell differentiation in hindbrain (GO:0021533)2.71000088
87magnesium ion transport (GO:0015693)2.70007034
88peripheral nervous system development (GO:0007422)2.69941038
89postsynaptic membrane organization (GO:0001941)2.69741222
90positive regulation of muscle hypertrophy (GO:0014742)2.69050425
91positive regulation of cardiac muscle hypertrophy (GO:0010613)2.69050425
92protein palmitoylation (GO:0018345)2.67363767
93positive regulation of synapse assembly (GO:0051965)2.67248985
94neuron-neuron synaptic transmission (GO:0007270)2.67042601
95innervation (GO:0060384)2.66578544
96sodium ion export (GO:0071436)2.65541760
97vocalization behavior (GO:0071625)2.65221852
98neuron recognition (GO:0008038)2.64142203
99negative chemotaxis (GO:0050919)2.62430938
100central nervous system projection neuron axonogenesis (GO:0021952)2.61609689
101regulation of synaptic transmission, glutamatergic (GO:0051966)2.61329762
102regulation of dendritic spine development (GO:0060998)2.61233143
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60778477
104startle response (GO:0001964)2.60435436
105positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59352229
106adult locomotory behavior (GO:0008344)2.59300474
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.58488765
108response to monoamine (GO:0071867)2.57171543
109response to catecholamine (GO:0071869)2.57171543
110glycine transport (GO:0015816)2.57040264
111retina layer formation (GO:0010842)2.57028839
112positive regulation of oligodendrocyte differentiation (GO:0048714)2.56561365
113Golgi to endosome transport (GO:0006895)2.56490708
114preassembly of GPI anchor in ER membrane (GO:0016254)2.56050553
115glutamate receptor signaling pathway (GO:0007215)2.55639581
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.55597109
117exploration behavior (GO:0035640)2.55496809
118GPI anchor metabolic process (GO:0006505)2.55463963
119negative regulation of execution phase of apoptosis (GO:1900118)2.55431510
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55039581
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54538485
122GPI anchor biosynthetic process (GO:0006506)2.54054268
123response to methylmercury (GO:0051597)2.54014863
124synapse assembly (GO:0007416)2.53954938
125negative regulation of axon extension (GO:0030517)2.52687156
126membrane depolarization during action potential (GO:0086010)2.51651450
127positive regulation of potassium ion transport (GO:0043268)2.50370093
128heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.49286685
129acidic amino acid transport (GO:0015800)2.47848139
130glycosylceramide metabolic process (GO:0006677)2.46877707
131neurotransmitter uptake (GO:0001504)2.46706062
132positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.46555304
133regulation of voltage-gated calcium channel activity (GO:1901385)2.46060635
134creatine metabolic process (GO:0006600)2.46049761
135glycosphingolipid biosynthetic process (GO:0006688)2.45928205
136regulation of postsynaptic membrane potential (GO:0060078)2.45162709
137response to histamine (GO:0034776)2.44983255
138inner ear receptor cell development (GO:0060119)2.44846803
139long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.44499252
140positive regulation of dendrite morphogenesis (GO:0050775)2.43102949
141retinal ganglion cell axon guidance (GO:0031290)2.42986016
142striatum development (GO:0021756)2.42170010
143protein localization to synapse (GO:0035418)2.41044990
144regulation of potassium ion transmembrane transporter activity (GO:1901016)2.40983983
145synapse organization (GO:0050808)2.40351803
146dendrite development (GO:0016358)2.40203141
147synaptic vesicle exocytosis (GO:0016079)2.39533402
148neuromuscular synaptic transmission (GO:0007274)2.39332223
149membrane tubulation (GO:0097320)2.38813554
150regulation of short-term neuronal synaptic plasticity (GO:0048172)2.38700259
151neurofilament cytoskeleton organization (GO:0060052)2.38643573
152regulation of cell communication by electrical coupling (GO:0010649)2.38254100
153axonal fasciculation (GO:0007413)2.37138685
154neuronal action potential (GO:0019228)2.37089550
155neuron remodeling (GO:0016322)2.36900340
156long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.35588728
157nucleotide transmembrane transport (GO:1901679)2.35388956
158regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35365051
159regulation of synapse assembly (GO:0051963)2.35267333
160ER overload response (GO:0006983)2.35034163
161membrane hyperpolarization (GO:0060081)2.33832948
162synaptic vesicle endocytosis (GO:0048488)2.33128849
163regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33124785
164nerve growth factor signaling pathway (GO:0038180)2.32799369
165regulation of synaptic vesicle exocytosis (GO:2000300)2.32789346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.07611049
2EZH2_22144423_ChIP-Seq_EOC_Human3.15466696
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55619282
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50889172
5TAF15_26573619_Chip-Seq_HEK293_Human2.47921947
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45026316
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37204987
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32348984
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.26382020
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.17855841
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13211570
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12820803
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12820803
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10668681
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10609589
16* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06691205
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05507734
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.03138381
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00098273
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.96636865
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91370033
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88837740
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.87170443
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.81957481
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80614253
26* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80297864
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79696007
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78220994
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76596578
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72660118
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72290795
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.70583000
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69400302
34AR_21572438_ChIP-Seq_LNCaP_Human1.69273874
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.69057423
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68843471
37EWS_26573619_Chip-Seq_HEK293_Human1.67641083
38ER_23166858_ChIP-Seq_MCF-7_Human1.65632123
39* P300_19829295_ChIP-Seq_ESCs_Human1.64949640
40VDR_22108803_ChIP-Seq_LS180_Human1.64267365
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.63369016
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62737655
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62733992
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62696579
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61319091
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59845285
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.57924429
48* DROSHA_22980978_ChIP-Seq_HELA_Human1.57876716
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55981838
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55911477
51SMAD4_21799915_ChIP-Seq_A2780_Human1.54698167
52REST_21632747_ChIP-Seq_MESCs_Mouse1.49895982
53FUS_26573619_Chip-Seq_HEK293_Human1.46083135
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45741347
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43417306
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.42356272
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41133809
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41059793
59RNF2_27304074_Chip-Seq_NSC_Mouse1.40892707
60* STAT3_23295773_ChIP-Seq_U87_Human1.40776377
61TP53_16413492_ChIP-PET_HCT116_Human1.39145294
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38263840
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36316269
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35085499
65IGF1R_20145208_ChIP-Seq_DFB_Human1.34362330
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32981532
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32981532
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.32353374
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31967685
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31806827
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.31369563
72SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31083107
73* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29066399
74SOX9_26525672_Chip-Seq_HEART_Mouse1.27055587
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.26003904
76* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25372336
77TCF4_23295773_ChIP-Seq_U87_Human1.25046155
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.24974272
79P53_22387025_ChIP-Seq_ESCs_Mouse1.24682665
80BCAT_22108803_ChIP-Seq_LS180_Human1.24364836
81P300_18555785_Chip-Seq_ESCs_Mouse1.21634853
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21458583
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20360458
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20236907
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.19346069
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18452386
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18226085
88JUN_21703547_ChIP-Seq_K562_Human1.16209385
89TAL1_26923725_Chip-Seq_HPCs_Mouse1.15826246
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15307370
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.15075249
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14802225
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14556053
94SMAD3_21741376_ChIP-Seq_HESCs_Human1.14499919
95ZNF274_21170338_ChIP-Seq_K562_Hela1.14395194
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13342015
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12770079
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11057245
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10713711
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09819465
101RUNX2_22187159_ChIP-Seq_PCA_Human1.09743002
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09708790
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09687195
104RARB_27405468_Chip-Seq_BRAIN_Mouse1.09017689
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.08794581
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.08365071
107* EZH2_27294783_Chip-Seq_NPCs_Mouse1.08142929
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07527559
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.05802069
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05791467
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05113727
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04927976
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.04816361
114CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04489532
115AR_25329375_ChIP-Seq_VCAP_Human1.04370135
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03943002
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.03782751
118TP53_18474530_ChIP-ChIP_U2OS_Human1.03733530
119* ARNT_22903824_ChIP-Seq_MCF-7_Human1.03704082
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02897225
121KDM2B_26808549_Chip-Seq_REH_Human1.02468212
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.01660514
123NMYC_18555785_Chip-Seq_ESCs_Mouse1.01321730
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.00678162
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99228655
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99228655

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.38996537
2MP0000920_abnormal_myelination4.05741361
3MP0004270_analgesia3.52075013
4MP0004859_abnormal_synaptic_plasticity3.28098205
5MP0005171_absent_coat_pigmentation2.81400454
6MP0001486_abnormal_startle_reflex2.79216072
7MP0002272_abnormal_nervous_system2.74906496
8MP0002064_seizures2.59186833
9MP0009046_muscle_twitch2.48961284
10MP0003635_abnormal_synaptic_transmissio2.44739396
11MP0003950_abnormal_plasma_membrane2.43818243
12MP0003690_abnormal_glial_cell2.42483524
13MP0001529_abnormal_vocalization2.41432366
14MP0008438_abnormal_cutaneous_collagen2.40113364
15MP0003136_yellow_coat_color2.37560225
16MP0009745_abnormal_behavioral_response2.37245519
17MP0005409_darkened_coat_color2.26608687
18MP0000778_abnormal_nervous_system2.26428630
19MP0002734_abnormal_mechanical_nocicepti2.14695973
20MP0004142_abnormal_muscle_tone2.14461416
21MP0004885_abnormal_endolymph2.13604297
22MP0004742_abnormal_vestibular_system2.11324476
23MP0005423_abnormal_somatic_nervous2.08758183
24MP0001905_abnormal_dopamine_level2.05225498
25MP0002735_abnormal_chemical_nociception2.04474934
26MP0001485_abnormal_pinna_reflex1.91707573
27MP0002063_abnormal_learning/memory/cond1.88755402
28MP0010386_abnormal_urinary_bladder1.87668029
29MP0003122_maternal_imprinting1.87505513
30MP0002572_abnormal_emotion/affect_behav1.84581360
31MP0003634_abnormal_glial_cell1.83432804
32MP0001968_abnormal_touch/_nociception1.77703347
33MP0003329_amyloid_beta_deposits1.74292469
34MP0002067_abnormal_sensory_capabilities1.66832568
35MP0010030_abnormal_orbit_morphology1.64996722
36MP0002736_abnormal_nociception_after1.64747787
37MP0005646_abnormal_pituitary_gland1.64036315
38MP0002229_neurodegeneration1.63951149
39MP0001440_abnormal_grooming_behavior1.59615381
40MP0000955_abnormal_spinal_cord1.57686406
41MP0004147_increased_porphyrin_level1.51478098
42MP0003632_abnormal_nervous_system1.46132491
43MP0002882_abnormal_neuron_morphology1.44484504
44MP0008877_abnormal_DNA_methylation1.43830132
45MP0000566_synostosis1.43663908
46MP0008260_abnormal_autophagy1.42532124
47MP0000534_abnormal_ureter_morphology1.40077227
48MP0001970_abnormal_pain_threshold1.39931629
49MP0008569_lethality_at_weaning1.37324593
50MP0005551_abnormal_eye_electrophysiolog1.37196980
51MP0001986_abnormal_taste_sensitivity1.36809954
52MP0004924_abnormal_behavior1.36432328
53MP0005386_behavior/neurological_phenoty1.36432328
54MP0002751_abnormal_autonomic_nervous1.36392462
55MP0005503_abnormal_tendon_morphology1.35332737
56MP0005645_abnormal_hypothalamus_physiol1.34038392
57MP0001963_abnormal_hearing_physiology1.33719507
58MP0006054_spinal_hemorrhage1.33688781
59MP0004272_abnormal_basement_membrane1.32848769
60MP0005451_abnormal_body_composition1.31798851
61MP0001188_hyperpigmentation1.31356246
62MP0004134_abnormal_chest_morphology1.30117187
63MP0002066_abnormal_motor_capabilities/c1.29664289
64MP0005410_abnormal_fertilization1.27607326
65MP0002733_abnormal_thermal_nociception1.27406163
66MP0005275_abnormal_skin_tensile1.25032272
67MP0003385_abnormal_body_wall1.23563383
68MP0002184_abnormal_innervation1.23403680
69MP0001501_abnormal_sleep_pattern1.20726637
70MP0002752_abnormal_somatic_nervous1.19946366
71MP0006276_abnormal_autonomic_nervous1.19038276
72MP0000569_abnormal_digit_pigmentation1.17796844
73MP0003631_nervous_system_phenotype1.16561793
74MP0001984_abnormal_olfaction1.16405206
75MP0003121_genomic_imprinting1.16052904
76MP0000049_abnormal_middle_ear1.15993502
77MP0000383_abnormal_hair_follicle1.13119515
78MP0003942_abnormal_urinary_system1.10779021
79MP0001502_abnormal_circadian_rhythm1.08748414
80MP0002557_abnormal_social/conspecific_i1.07988773
81MP0001299_abnormal_eye_distance/1.07961021
82MP0003937_abnormal_limbs/digits/tail_de1.07694187
83MP0009250_abnormal_appendicular_skeleto1.07591767
84MP0008789_abnormal_olfactory_epithelium1.06722241
85MP0000462_abnormal_digestive_system1.06418059
86MP0004381_abnormal_hair_follicle1.05252021
87MP0002233_abnormal_nose_morphology1.03361884
88MP0000015_abnormal_ear_pigmentation1.02489619
89MP0005187_abnormal_penis_morphology1.02026443
90MP0005394_taste/olfaction_phenotype1.00820927
91MP0005499_abnormal_olfactory_system1.00820927
92MP0000026_abnormal_inner_ear1.00353324
93MP0003633_abnormal_nervous_system0.99733960
94MP0006072_abnormal_retinal_apoptosis0.98841093
95MP0001346_abnormal_lacrimal_gland0.96804639
96MP0004043_abnormal_pH_regulation0.94527442
97MP0010678_abnormal_skin_adnexa0.93956249
98MP0003861_abnormal_nervous_system0.93677778
99MP0001177_atelectasis0.93631148
100MP0003119_abnormal_digestive_system0.92751216
101MP0003938_abnormal_ear_development0.92653816
102MP0002822_catalepsy0.91855398
103MP0003755_abnormal_palate_morphology0.91407570
104MP0009384_cardiac_valve_regurgitation0.87603542
105MP0004811_abnormal_neuron_physiology0.87408454
106MP0002152_abnormal_brain_morphology0.85491279
107MP0002638_abnormal_pupillary_reflex0.84876878
108MP0000537_abnormal_urethra_morphology0.83802304
109MP0000538_abnormal_urinary_bladder0.82946708
110MP0003137_abnormal_impulse_conducting0.82921307
111MP0003787_abnormal_imprinting0.81425093
112MP0000428_abnormal_craniofacial_morphol0.81225724
113MP0002160_abnormal_reproductive_system0.80357139
114MP0000631_abnormal_neuroendocrine_gland0.80027512
115MP0000751_myopathy0.79963542
116MP0005248_abnormal_Harderian_gland0.79485417
117MP0009780_abnormal_chondrocyte_physiolo0.77841918
118MP0004133_heterotaxia0.76578513
119MP0009053_abnormal_anal_canal0.75124044
120MP0004145_abnormal_muscle_electrophysio0.74362371
121MP0003890_abnormal_embryonic-extraembry0.74032815
122MP0002234_abnormal_pharynx_morphology0.73695815
123MP0005623_abnormal_meninges_morphology0.73239550
124MP0005253_abnormal_eye_physiology0.72898964
125MP0000372_irregular_coat_pigmentation0.72477091
126MP0003879_abnormal_hair_cell0.72179955
127MP0005620_abnormal_muscle_contractility0.71705842
128MP0003935_abnormal_craniofacial_develop0.71629111
129MP0002876_abnormal_thyroid_physiology0.70347790
130MP0002295_abnormal_pulmonary_circulatio0.70273987
131MP0001661_extended_life_span0.70178498
132MP0000604_amyloidosis0.69712085
133MP0000579_abnormal_nail_morphology0.69609588
134MP0005195_abnormal_posterior_eye0.68251959
135MP0001348_abnormal_lacrimal_gland0.65457453
136MP0002102_abnormal_ear_morphology0.61113452
137MP0004085_abnormal_heartbeat0.60882743
138MP0001664_abnormal_digestion0.60313829
139MP0002108_abnormal_muscle_morphology0.59454661
140MP0005058_abnormal_lysosome_morphology0.58168024
141MP0000762_abnormal_tongue_morphology0.56300350

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.37921502
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.37921502
3Sensory axonal neuropathy (HP:0003390)5.11236579
4Neurofibrillary tangles (HP:0002185)4.54573541
5Focal motor seizures (HP:0011153)4.13555879
6Abnormality of the corticospinal tract (HP:0002492)4.12636333
7Parakeratosis (HP:0001036)3.87187981
8Atonic seizures (HP:0010819)3.68334669
9Peripheral hypomyelination (HP:0007182)3.64406533
10Follicular hyperkeratosis (HP:0007502)3.37197364
11Supranuclear gaze palsy (HP:0000605)3.34183672
12Myokymia (HP:0002411)3.32957100
13Spastic gait (HP:0002064)3.26583711
14Akinesia (HP:0002304)3.24305477
15Febrile seizures (HP:0002373)3.11007123
16Onion bulb formation (HP:0003383)3.09103615
17Abnormality of dentin (HP:0010299)3.06358025
18Premature rupture of membranes (HP:0001788)3.02129336
19Dysdiadochokinesis (HP:0002075)3.02028836
20Dysmetria (HP:0001310)2.93734712
21Impaired vibration sensation in the lower limbs (HP:0002166)2.92164621
22Cerebral inclusion bodies (HP:0100314)2.91679645
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.83694288
24Retinal dysplasia (HP:0007973)2.83541017
25Epileptic encephalopathy (HP:0200134)2.82322772
26Hyperventilation (HP:0002883)2.80588984
27Focal seizures (HP:0007359)2.80144017
28Intention tremor (HP:0002080)2.76615740
29Scanning speech (HP:0002168)2.72299104
30Absent septum pellucidum (HP:0001331)2.71246947
31Alacrima (HP:0000522)2.67794917
32Cerebral hypomyelination (HP:0006808)2.65312182
33Clumsiness (HP:0002312)2.57740231
34Thickened helices (HP:0000391)2.54033950
35Slow saccadic eye movements (HP:0000514)2.53400021
36Drooling (HP:0002307)2.52006591
37Abnormal auditory evoked potentials (HP:0006958)2.50269601
38Septo-optic dysplasia (HP:0100842)2.50211565
39Aplasia of the phalanges of the hand (HP:0009802)2.50090625
40Aplasia involving bones of the extremities (HP:0009825)2.50090625
41Aplasia involving bones of the upper limbs (HP:0009823)2.50090625
42Ankle clonus (HP:0011448)2.48661456
43Pheochromocytoma (HP:0002666)2.40473050
44Gait imbalance (HP:0002141)2.39621557
45Neonatal short-limb short stature (HP:0008921)2.39146775
46Split foot (HP:0001839)2.38273203
47Limb dystonia (HP:0002451)2.36331785
48Abnormality of the septum pellucidum (HP:0007375)2.33149834
49Abnormality of glycolysis (HP:0004366)2.32534288
50Increased serum pyruvate (HP:0003542)2.32534288
51Termporal pattern (HP:0011008)2.30795105
52Insidious onset (HP:0003587)2.30795105
53Gaze-evoked nystagmus (HP:0000640)2.30420398
54Truncal ataxia (HP:0002078)2.29410037
55Decreased lacrimation (HP:0000633)2.29358360
56Broad-based gait (HP:0002136)2.27597409
57Anteriorly placed anus (HP:0001545)2.25954938
58Aortic aneurysm (HP:0004942)2.25609350
59Horizontal nystagmus (HP:0000666)2.22610712
60Dialeptic seizures (HP:0011146)2.22354899
61Excessive salivation (HP:0003781)2.22169331
62Vascular tortuosity (HP:0004948)2.21319100
63Abnormal hair whorl (HP:0010721)2.18175628
64Fetal akinesia sequence (HP:0001989)2.17536469
65Leukodystrophy (HP:0002415)2.16724391
66Hypoplastic pelvis (HP:0008839)2.16643388
67Urinary urgency (HP:0000012)2.16415282
68Cupped ear (HP:0000378)2.15688030
69White forelock (HP:0002211)2.14895353
70Atrophic scars (HP:0001075)2.14398185
71Lower limb muscle weakness (HP:0007340)2.13908662
72Partial agenesis of the corpus callosum (HP:0001338)2.13167453
73Anomalous pulmonary venous return (HP:0010772)2.12574263
74Autoamputation (HP:0001218)2.11804949
75Neuroendocrine neoplasm (HP:0100634)2.11669555
76Synostosis involving the elbow (HP:0003938)2.11155473
77Humeroradial synostosis (HP:0003041)2.11155473
78Soft skin (HP:0000977)2.09047410
79Aortic dissection (HP:0002647)2.08577659
80Delayed gross motor development (HP:0002194)2.08091087
81Blue irides (HP:0000635)2.08018646
82Patchy hypopigmentation of hair (HP:0011365)2.06693603
83Absent speech (HP:0001344)2.06611498
84Dysmetric saccades (HP:0000641)2.06011964
85Congenital primary aphakia (HP:0007707)2.05769094
86Cutaneous finger syndactyly (HP:0010554)2.04106863
87Poor speech (HP:0002465)2.04063180
88Increased circulating renin level (HP:0000848)1.99130225
89Steppage gait (HP:0003376)1.99121737
90Nephrogenic diabetes insipidus (HP:0009806)1.98783415
91Arterial tortuosity (HP:0005116)1.97642891
92Abnormality of incisor morphology (HP:0011063)1.97280556
93Vaginal atresia (HP:0000148)1.96069745
94Postural tremor (HP:0002174)1.94751747
95Hemiparesis (HP:0001269)1.94548542
96Hypomagnesemia (HP:0002917)1.94431647
97Action tremor (HP:0002345)1.93712307
98Genital tract atresia (HP:0001827)1.93541186
99Hypoventilation (HP:0002791)1.93518897
100Conical tooth (HP:0000698)1.92646616
101Polyphagia (HP:0002591)1.92579497
102Optic nerve hypoplasia (HP:0000609)1.90920503
103Torticollis (HP:0000473)1.90671809
104Mild short stature (HP:0003502)1.87656825
105Duplicated collecting system (HP:0000081)1.87256863
106Protrusio acetabuli (HP:0003179)1.86877396
107Adrenal hypoplasia (HP:0000835)1.85898708
108Diminished movement (HP:0002374)1.85598212
109Congenital ichthyosiform erythroderma (HP:0007431)1.85548012
110Generalized tonic-clonic seizures (HP:0002069)1.85376655
111Decreased motor nerve conduction velocity (HP:0003431)1.84798226
112Morphological abnormality of the inner ear (HP:0011390)1.84608669
113Vitreoretinal degeneration (HP:0000655)1.83660333
114Progressive cerebellar ataxia (HP:0002073)1.83003638
115Abnormality of the lower motor neuron (HP:0002366)1.82960108
116Widely spaced teeth (HP:0000687)1.81877661
117Shallow orbits (HP:0000586)1.81793588
118Progressive inability to walk (HP:0002505)1.80740039
119Premature skin wrinkling (HP:0100678)1.80573769
120Absence seizures (HP:0002121)1.78929487
121Methylmalonic acidemia (HP:0002912)1.78214016
122Spastic paraparesis (HP:0002313)1.77441416
123Turricephaly (HP:0000262)1.76305374
124Metabolic alkalosis (HP:0200114)1.75968685
125Abnormality of the pulmonary veins (HP:0011718)1.75732228
126Congenital sensorineural hearing impairment (HP:0008527)1.75200719
127Broad metatarsal (HP:0001783)1.74483031
128Ankle contracture (HP:0006466)1.73632847
129Abnormality of the labia minora (HP:0012880)1.73407989
130Bladder diverticulum (HP:0000015)1.73085917
131Abnormal eating behavior (HP:0100738)1.72711326
132Barrel-shaped chest (HP:0001552)1.72703455
133Generalized myoclonic seizures (HP:0002123)1.71526602
134Morphological abnormality of the pyramidal tract (HP:0002062)1.71107620
135Stridor (HP:0010307)1.70179832
136Relative macrocephaly (HP:0004482)1.70064952
137Megalencephaly (HP:0001355)1.69941654
138Hypoplasia of the iris (HP:0007676)1.69925870
139Medial flaring of the eyebrow (HP:0010747)1.69509129
140Amblyopia (HP:0000646)1.69300782
141Amyotrophic lateral sclerosis (HP:0007354)1.69139960
142Keratoconus (HP:0000563)1.67843734
143Increased corneal curvature (HP:0100692)1.67843734
144Focal dystonia (HP:0004373)1.67088614
145Cutaneous syndactyly (HP:0012725)1.66964345
146Abnormal ciliary motility (HP:0012262)1.60010120
147Impaired smooth pursuit (HP:0007772)1.56491088
148Epileptiform EEG discharges (HP:0011182)1.56316180
149Bifid tongue (HP:0010297)1.55965558
150Bowel diverticulosis (HP:0005222)1.54980731
151Volvulus (HP:0002580)1.54110627
152Coronal craniosynostosis (HP:0004440)1.53040584
153Impaired vibratory sensation (HP:0002495)1.52280912
154Short foot (HP:0001773)1.51532437
155Morphological abnormality of the middle ear (HP:0008609)1.50351333
156Wormian bones (HP:0002645)1.49373337
157Abnormality of ocular smooth pursuit (HP:0000617)1.48256742
158Gait ataxia (HP:0002066)1.47392314
159Postaxial hand polydactyly (HP:0001162)1.45957089
160Aplasia/Hypoplasia of the lens (HP:0008063)1.44985673
161Poor coordination (HP:0002370)1.42209731
162Incomplete penetrance (HP:0003829)1.42050744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.95266617
2OXSR13.78520908
3TNIK3.66235343
4PRPF4B3.57057547
5CASK3.51002171
6BCR2.87936289
7MAP3K92.71487785
8EPHB12.36873503
9CDK192.12312205
10PKN12.09285126
11WNK42.08203899
12WNK12.05347975
13EPHA42.04866396
14NTRK32.03745431
15NEK62.01921161
16MYLK1.81750017
17MAP3K121.75054318
18MET1.53575406
19LATS21.49771367
20MAP2K71.48823630
21CSNK1A1L1.46807837
22PAK61.44868300
23UHMK11.40207054
24ICK1.37353753
25WNK31.35846780
26EPHB21.34593359
27CSNK1G31.32015810
28FGFR21.31907957
29SGK2231.31096832
30SGK4941.31096832
31PBK1.31093879
32MARK11.30892926
33CAMK2B1.27052926
34PDGFRA1.26311341
35ERBB31.25317636
36CLK11.24519721
37CCNB11.24024622
38CAMKK21.20798867
39MAPK131.18732840
40LIMK11.18511214
41ROCK21.13693640
42CSNK1G21.11860408
43LATS11.11667904
44CAMK2D1.08530592
45PNCK1.06296004
46MAP3K41.05760249
47MAPKAPK51.05540172
48FGR1.05464431
49MOS1.04606964
50BMPR1B1.03495231
51NTRK11.01982196
52CSNK1G11.01015881
53PRKCE1.00139579
54CAMK1G0.97466275
55CDK50.97061809
56FRK0.95621671
57CAMK2A0.94332507
58BMPR20.92328994
59MUSK0.90057923
60CAMK2G0.89056344
61MAP3K60.88730049
62PRKCQ0.86608740
63TRIM280.85084006
64PAK30.82530795
65NTRK20.79778152
66CAMK10.79584866
67STK38L0.79389319
68MST40.78535235
69PAK20.78115432
70ERBB40.74910626
71PHKG10.74853150
72PHKG20.74853150
73ARAF0.73370238
74ADRBK20.73361049
75MAP3K130.73025639
76MAP2K40.72472272
77PTK20.70023999
78MINK10.69993098
79INSRR0.69310012
80GRK70.67913066
81PLK20.66800585
82DDR20.65868364
83DYRK20.63307665
84CDK140.62964029
85NEK90.60877048
86BRAF0.60014212
87TRPM70.58545922
88PRKCH0.58341993
89CDK180.58327770
90CDK150.57054096
91IRAK10.56103797
92OBSCN0.55864321
93PRKG10.55359779
94STK380.53288850
95PINK10.52959759
96MARK20.52919866
97PRKD30.52270349
98ADRBK10.51970221
99PTK2B0.49934987
100CDK11A0.49244104
101IRAK20.49206594
102FYN0.49029434
103TTK0.48035350
104DYRK30.47381753
105CAMKK10.47079837
106PRKCG0.46621991
107RAF10.46282494
108NUAK10.46238735
109FES0.45964622
110AKT30.45657767
111MAP3K50.45134742
112CSNK1A10.45118770
113WEE10.43407893
114CAMK40.43339985
115GRK50.42680523
116PDPK10.41930550
117CDK30.41634982
118SRPK10.41617511
119TIE10.41020231
120TYRO30.41010293
121TNK20.40238955
122RPS6KA30.40148475
123SGK10.39629081
124EPHA30.39464202
125DYRK1A0.38760340
126DAPK10.38503345
127MAP3K140.37378528
128SGK20.36712705
129PRKACA0.36087386
130PIK3CA0.35552057
131STK110.35067485
132ROCK10.34839819
133STK160.34420918
134CSNK1D0.34153053
135PRKACB0.34056870
136KSR20.33357660
137GRK10.32747566
138KSR10.32694012

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.83895366
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.58986474
3Fatty acid elongation_Homo sapiens_hsa000623.03080907
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76699736
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.73375257
6Ether lipid metabolism_Homo sapiens_hsa005652.52825146
7Nicotine addiction_Homo sapiens_hsa050332.42130430
8Axon guidance_Homo sapiens_hsa043602.01475501
9Glutamatergic synapse_Homo sapiens_hsa047241.97996425
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96645076
11Morphine addiction_Homo sapiens_hsa050321.96484059
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90292810
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85885257
14GABAergic synapse_Homo sapiens_hsa047271.84679632
15Oxidative phosphorylation_Homo sapiens_hsa001901.80032022
16Serotonergic synapse_Homo sapiens_hsa047261.79629097
17Sphingolipid metabolism_Homo sapiens_hsa006001.78566800
18Synaptic vesicle cycle_Homo sapiens_hsa047211.68585540
19Collecting duct acid secretion_Homo sapiens_hsa049661.65757937
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59558903
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57518062
22Nitrogen metabolism_Homo sapiens_hsa009101.54955544
23Circadian entrainment_Homo sapiens_hsa047131.53243363
24Long-term depression_Homo sapiens_hsa047301.38535987
25ECM-receptor interaction_Homo sapiens_hsa045121.36702222
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33462021
27Olfactory transduction_Homo sapiens_hsa047401.30704745
28Taste transduction_Homo sapiens_hsa047421.29920106
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.24687600
30Salivary secretion_Homo sapiens_hsa049701.24047500
31Alzheimers disease_Homo sapiens_hsa050101.23750729
32Hippo signaling pathway_Homo sapiens_hsa043901.23071527
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19355248
34Vibrio cholerae infection_Homo sapiens_hsa051101.19055491
35Rheumatoid arthritis_Homo sapiens_hsa053231.15554618
36Linoleic acid metabolism_Homo sapiens_hsa005911.12611261
37Cardiac muscle contraction_Homo sapiens_hsa042601.12542209
38Oocyte meiosis_Homo sapiens_hsa041141.12035589
39Phototransduction_Homo sapiens_hsa047441.10679501
40Cholinergic synapse_Homo sapiens_hsa047251.10500825
41Parkinsons disease_Homo sapiens_hsa050121.08270751
42Basal cell carcinoma_Homo sapiens_hsa052171.07799823
43Dopaminergic synapse_Homo sapiens_hsa047281.04126289
44ErbB signaling pathway_Homo sapiens_hsa040121.01112449
45Circadian rhythm_Homo sapiens_hsa047101.01001710
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00322755
47Ovarian steroidogenesis_Homo sapiens_hsa049130.99985625
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99357043
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98708867
50Amphetamine addiction_Homo sapiens_hsa050310.96723512
51Calcium signaling pathway_Homo sapiens_hsa040200.96400555
52Cocaine addiction_Homo sapiens_hsa050300.94941061
53Sulfur metabolism_Homo sapiens_hsa009200.94280837
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.93269831
55Autoimmune thyroid disease_Homo sapiens_hsa053200.92273847
56Ras signaling pathway_Homo sapiens_hsa040140.91346395
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.91130766
58Focal adhesion_Homo sapiens_hsa045100.89731018
59Protein export_Homo sapiens_hsa030600.89460415
60Estrogen signaling pathway_Homo sapiens_hsa049150.88668781
61Butanoate metabolism_Homo sapiens_hsa006500.86764533
62Long-term potentiation_Homo sapiens_hsa047200.86392657
63Vitamin B6 metabolism_Homo sapiens_hsa007500.85620047
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85423189
65Insulin secretion_Homo sapiens_hsa049110.83883083
66Thyroid hormone synthesis_Homo sapiens_hsa049180.83493377
67Gastric acid secretion_Homo sapiens_hsa049710.81718992
68Protein digestion and absorption_Homo sapiens_hsa049740.79779397
69Arachidonic acid metabolism_Homo sapiens_hsa005900.79055360
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77611796
71cAMP signaling pathway_Homo sapiens_hsa040240.76850217
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.76330914
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76138956
74Renin secretion_Homo sapiens_hsa049240.75207018
75TGF-beta signaling pathway_Homo sapiens_hsa043500.75077237
76Dorso-ventral axis formation_Homo sapiens_hsa043200.75035078
77Histidine metabolism_Homo sapiens_hsa003400.73689176
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71803788
79Glioma_Homo sapiens_hsa052140.71738749
80Rap1 signaling pathway_Homo sapiens_hsa040150.71429747
81Melanoma_Homo sapiens_hsa052180.70435435
82Arginine and proline metabolism_Homo sapiens_hsa003300.69289936
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67870457
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67744421
85Phagosome_Homo sapiens_hsa041450.67340275
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66891974
87Tight junction_Homo sapiens_hsa045300.66588640
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66407358
89Oxytocin signaling pathway_Homo sapiens_hsa049210.64038418
90Renal cell carcinoma_Homo sapiens_hsa052110.63371733
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63045584
92Endocytosis_Homo sapiens_hsa041440.62730811
93Choline metabolism in cancer_Homo sapiens_hsa052310.62560513
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59357342
95Dilated cardiomyopathy_Homo sapiens_hsa054140.57125141
96Huntingtons disease_Homo sapiens_hsa050160.55538505
97Gap junction_Homo sapiens_hsa045400.55363431
98Proteoglycans in cancer_Homo sapiens_hsa052050.54960376
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54792967
100Inositol phosphate metabolism_Homo sapiens_hsa005620.54257782
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.53656114
102Pancreatic secretion_Homo sapiens_hsa049720.53544947
103Propanoate metabolism_Homo sapiens_hsa006400.53378415
104Alcoholism_Homo sapiens_hsa050340.52694366
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51459166
106Adherens junction_Homo sapiens_hsa045200.51196066
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50776058
108MAPK signaling pathway_Homo sapiens_hsa040100.50683612
109Mineral absorption_Homo sapiens_hsa049780.49199762
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.49138562
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48648644
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48092692
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47015943
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45561160
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45064172
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44531078
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44309369
118Malaria_Homo sapiens_hsa051440.44182885
119Hedgehog signaling pathway_Homo sapiens_hsa043400.43520362
120GnRH signaling pathway_Homo sapiens_hsa049120.42605889
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42321162
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42029827
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41851680
124Basal transcription factors_Homo sapiens_hsa030220.40606779
125Melanogenesis_Homo sapiens_hsa049160.40458138
126Chemokine signaling pathway_Homo sapiens_hsa040620.40306645
127Lysosome_Homo sapiens_hsa041420.40197412
128Regulation of autophagy_Homo sapiens_hsa041400.39382371
129Wnt signaling pathway_Homo sapiens_hsa043100.39129195
130Type II diabetes mellitus_Homo sapiens_hsa049300.38000737
131Pathways in cancer_Homo sapiens_hsa052000.32633256
132Prion diseases_Homo sapiens_hsa050200.31987536
133Amoebiasis_Homo sapiens_hsa051460.31472393
134Glucagon signaling pathway_Homo sapiens_hsa049220.27096565

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