ANO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96488460
2cell adhesion mediated by integrin (GO:0033627)3.63820211
3low-density lipoprotein particle clearance (GO:0034383)3.63325173
4regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.49428387
5hypotonic response (GO:0006971)3.39941517
6vascular endothelial growth factor signaling pathway (GO:0038084)3.39652840
7hemidesmosome assembly (GO:0031581)3.37208708
8pinocytosis (GO:0006907)3.26826313
9protein localization to endosome (GO:0036010)3.23668222
10platelet degranulation (GO:0002576)3.11804087
11positive regulation of receptor recycling (GO:0001921)3.07572678
12angiogenesis involved in wound healing (GO:0060055)2.99568341
13negative regulation of fatty acid transport (GO:2000192)2.98109741
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97871443
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97871443
16negative regulation of protein localization to plasma membrane (GO:1903077)2.97511586
17stress fiber assembly (GO:0043149)2.96870179
18apoptotic cell clearance (GO:0043277)2.96377106
19regulation of transforming growth factor beta2 production (GO:0032909)2.93964726
20protein heterotrimerization (GO:0070208)2.93288921
21positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88820030
22barbed-end actin filament capping (GO:0051016)2.86477758
23axon extension involved in axon guidance (GO:0048846)2.85690445
24neuron projection extension involved in neuron projection guidance (GO:1902284)2.85690445
25definitive hemopoiesis (GO:0060216)2.83597468
26skin morphogenesis (GO:0043589)2.82890360
27endodermal cell differentiation (GO:0035987)2.82272313
28adherens junction assembly (GO:0034333)2.80495647
29cellular response to vitamin D (GO:0071305)2.80146514
30negative regulation of homotypic cell-cell adhesion (GO:0034111)2.80127821
31fibrinolysis (GO:0042730)2.79761736
32focal adhesion assembly (GO:0048041)2.79523687
33cell-substrate adherens junction assembly (GO:0007045)2.79523687
34wound healing, spreading of epidermal cells (GO:0035313)2.78760297
35negative regulation of fibrinolysis (GO:0051918)2.77805232
36collagen fibril organization (GO:0030199)2.77526307
37chondrocyte proliferation (GO:0035988)2.76250096
38regulation of early endosome to late endosome transport (GO:2000641)2.75817956
39basement membrane organization (GO:0071711)2.75770462
40blood coagulation, intrinsic pathway (GO:0007597)2.74565761
41cellular response to vitamin (GO:0071295)2.74155233
42alpha-linolenic acid metabolic process (GO:0036109)2.70335322
43Golgi transport vesicle coating (GO:0048200)2.69072990
44COPI coating of Golgi vesicle (GO:0048205)2.69072990
45embryonic process involved in female pregnancy (GO:0060136)2.68032840
46negative regulation of platelet activation (GO:0010544)2.64794531
47thrombin receptor signaling pathway (GO:0070493)2.63919921
48regulation of integrin-mediated signaling pathway (GO:2001044)2.63682139
49cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61897627
50positive regulation of macrophage differentiation (GO:0045651)2.61728146
51negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.59584895
52platelet aggregation (GO:0070527)2.57384599
53retina vasculature morphogenesis in camera-type eye (GO:0061299)2.57380773
54mRNA transcription (GO:0009299)2.57308696
55* positive regulation of blood coagulation (GO:0030194)2.56258631
56* positive regulation of hemostasis (GO:1900048)2.56258631
57germ cell migration (GO:0008354)2.55817344
58negative regulation of lipid transport (GO:0032369)2.55727099
59extracellular fibril organization (GO:0043206)2.55453444
60regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.54999760
61positive regulation of extracellular matrix organization (GO:1903055)2.53793754
62positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.52266467
63fibril organization (GO:0097435)2.52038603
64renal filtration (GO:0097205)2.51719502
65response to interferon-alpha (GO:0035455)2.50639520
66negative regulation of blood coagulation (GO:0030195)2.50116144
67negative regulation of hemostasis (GO:1900047)2.50116144
68positive regulation of keratinocyte differentiation (GO:0045618)2.48613320
69substrate-dependent cell migration (GO:0006929)2.48299578
70antigen processing and presentation of endogenous antigen (GO:0019883)2.47675293
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46613607
72positive regulation of natural killer cell differentiation (GO:0032825)2.46495507
73* positive regulation of coagulation (GO:0050820)2.46472639
74mesodermal cell differentiation (GO:0048333)2.44692383
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.44670244
76hepatocyte apoptotic process (GO:0097284)2.44154189
77glomerular basement membrane development (GO:0032836)2.43606065
78protein carboxylation (GO:0018214)2.43329180
79peptidyl-glutamic acid carboxylation (GO:0017187)2.43329180
80epithelial cell-cell adhesion (GO:0090136)2.40863768
81negative regulation of coagulation (GO:0050819)2.40051349
82positive regulation of gamma-delta T cell activation (GO:0046645)2.39227378
83regulation of platelet activation (GO:0010543)2.39018923
84regulation of lipoprotein metabolic process (GO:0050746)2.38117636
85regulation of membrane protein ectodomain proteolysis (GO:0051043)2.37697935
86cell-substrate junction assembly (GO:0007044)2.37635357
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37280715
88positive regulation of histone deacetylation (GO:0031065)2.37135430
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.36643144
90plasma lipoprotein particle clearance (GO:0034381)2.36500246
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.36418583
92establishment of endothelial barrier (GO:0061028)2.36393383
93negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.35800257
94angiotensin maturation (GO:0002003)2.35018834
95antigen processing and presentation via MHC class Ib (GO:0002475)2.34494725
96negative regulation of wound healing (GO:0061045)2.33821784
97response to laminar fluid shear stress (GO:0034616)2.33716576
98multicellular organismal catabolic process (GO:0044243)2.33611677
99muscle cell migration (GO:0014812)2.32957140
100multicellular organismal macromolecule metabolic process (GO:0044259)2.32344360
101virion attachment to host cell (GO:0019062)2.31880887
102adhesion of symbiont to host cell (GO:0044650)2.31880887
103negative regulation of erythrocyte differentiation (GO:0045647)2.31510148
104desmosome organization (GO:0002934)2.31248547
105negative regulation of anoikis (GO:2000811)2.30960764
106regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.30388466
107response to muramyl dipeptide (GO:0032495)2.29850142
108modulation by symbiont of host defense response (GO:0052031)2.29656257
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.29656257
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.29656257
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.29656257
112modulation by symbiont of host immune response (GO:0052553)2.29656257
113positive regulation by symbiont of host defense response (GO:0052509)2.29656257
114fibroblast migration (GO:0010761)2.29551263
115regulation of platelet aggregation (GO:0090330)2.29351113
116lymph vessel development (GO:0001945)2.28867096
117pattern specification involved in kidney development (GO:0061004)2.28708387
118collagen metabolic process (GO:0032963)2.28518878
119mRNA transcription from RNA polymerase II promoter (GO:0042789)2.28179216
120regulation of apoptotic process involved in morphogenesis (GO:1902337)2.27622143
121multicellular organismal metabolic process (GO:0044236)2.26835089
122wound healing, spreading of cells (GO:0044319)2.26543931
123sequestering of extracellular ligand from receptor (GO:0035581)2.26512050
124triglyceride catabolic process (GO:0019433)2.26294532
125positive regulation of Rho protein signal transduction (GO:0035025)2.25275695
126response to fluid shear stress (GO:0034405)2.25258632
127blood vessel maturation (GO:0001955)2.25188981
128hyaluronan catabolic process (GO:0030214)2.25024908
129mesenchymal-epithelial cell signaling (GO:0060638)2.22437536
130surfactant homeostasis (GO:0043129)2.20937614
131substrate adhesion-dependent cell spreading (GO:0034446)2.20836234
132protein localization to cell surface (GO:0034394)2.20817031
133adhesion of symbiont to host (GO:0044406)2.20670374
134collagen catabolic process (GO:0030574)2.19789694
135positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.19641868
136glomerular visceral epithelial cell development (GO:0072015)2.19627205
137cell-matrix adhesion (GO:0007160)2.19567948
138positive regulation of osteoblast proliferation (GO:0033690)2.19170391
139regulation of extracellular matrix disassembly (GO:0010715)2.18604928
140endothelium development (GO:0003158)2.18556582
141neutrophil activation involved in immune response (GO:0002283)2.18555438
142regulation of protein activation cascade (GO:2000257)2.18422377
143positive regulation of adherens junction organization (GO:1903393)2.18416342
144positive regulation of epithelial to mesenchymal transition (GO:0010718)2.18205244
145glomerular filtration (GO:0003094)2.17965851
146regulation of complement activation (GO:0030449)2.17825103
147membrane raft organization (GO:0031579)2.17725867
148cortical actin cytoskeleton organization (GO:0030866)2.17706108
149regulation of cholesterol homeostasis (GO:2000188)2.17393734
150neutral lipid catabolic process (GO:0046461)2.17284625
151acylglycerol catabolic process (GO:0046464)2.17284625
152regulation of macrophage derived foam cell differentiation (GO:0010743)2.17182347
153negative regulation of smooth muscle cell migration (GO:0014912)2.17174573
154low-density lipoprotein particle remodeling (GO:0034374)2.16963100
155regulation of interferon-beta biosynthetic process (GO:0045357)2.16812199
156peptide catabolic process (GO:0043171)2.16737594
157membrane protein ectodomain proteolysis (GO:0006509)2.16682264
158regulation of integrin activation (GO:0033623)2.16642997
159fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.16622876
160positive regulation of cell junction assembly (GO:1901890)2.16134422
161positive regulation of focal adhesion assembly (GO:0051894)2.16134422
162phospholipid homeostasis (GO:0055091)2.15842360
163endothelial tube morphogenesis (GO:0061154)2.15719908
164morphogenesis of an endothelium (GO:0003159)2.15719908
165pathway-restricted SMAD protein phosphorylation (GO:0060389)2.14551218
166regulation of cholesterol storage (GO:0010885)2.14522370
167regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.13761593
168leukocyte cell-cell adhesion (GO:0007159)2.12598407
169regulation of monocyte chemotaxis (GO:0090025)2.11716149
170Arp2/3 complex-mediated actin nucleation (GO:0034314)2.10878993
171radial glial cell differentiation (GO:0060019)2.10833888
172positive regulation of hormone biosynthetic process (GO:0046886)2.10748277
173integrin-mediated signaling pathway (GO:0007229)2.10508827
174negative regulation of phagocytosis (GO:0050765)2.10292793
175positive regulation of p38MAPK cascade (GO:1900745)2.09807670
176myoblast migration (GO:0051451)2.09627573
177coronary vasculature morphogenesis (GO:0060977)2.08862869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.14134210
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.80766607
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.65076021
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.49514223
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32464804
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.24923558
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05750153
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.92489212
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.86996756
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44441833
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42404457
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40067138
13GATA2_21666600_ChIP-Seq_HMVEC_Human2.28388074
14CLOCK_20551151_ChIP-Seq_293T_Human2.27717693
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.26408437
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24798688
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23363063
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22955350
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22795418
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.22057772
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.11661361
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10284135
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.08898890
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04630620
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.02995814
26SALL4_18804426_ChIP-ChIP_XEN_Mouse2.02180556
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01079113
28SCL_19346495_ChIP-Seq_HPC-7_Human2.00257755
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.94744980
30* LXR_22158963_ChIP-Seq_LIVER_Mouse1.94019615
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93239813
32RUNX_20019798_ChIP-Seq_JUKART_Human1.92480953
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.90473301
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89702691
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88752164
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88752164
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.86664589
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81394794
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81044037
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78324763
41VDR_24763502_ChIP-Seq_THP-1_Human1.72187232
42CJUN_26792858_Chip-Seq_BT549_Human1.72098682
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.71898797
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.70014272
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68535192
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68120107
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67948444
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.67236960
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61467371
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59796901
51* MAF_26560356_Chip-Seq_TH1_Human1.58644413
52MYB_26560356_Chip-Seq_TH2_Human1.58623198
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57631763
54SOX2_20726797_ChIP-Seq_SW620_Human1.55965536
55* SPI1_23127762_ChIP-Seq_K562_Human1.55494634
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.51352717
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.51352717
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50741463
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50287743
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49270841
61TCF7_22412390_ChIP-Seq_EML_Mouse1.49052755
62MYC_22102868_ChIP-Seq_BL_Human1.48349862
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47305017
64VDR_21846776_ChIP-Seq_THP-1_Human1.46768191
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46633656
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43817795
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43817795
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40367178
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40103960
70BRD4_25478319_ChIP-Seq_HGPS_Human1.39324401
71FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37738345
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37506897
73VDR_24787735_ChIP-Seq_THP-1_Human1.37504147
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36691847
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36341131
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.35365828
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.35271385
78* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34907629
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34068545
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.33512792
81* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33214352
82UTX_26944678_Chip-Seq_JUKART_Human1.32823946
83GATA1_22025678_ChIP-Seq_K562_Human1.32526123
84ZNF263_19887448_ChIP-Seq_K562_Human1.32110827
85* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.31738493
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29893132
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.29446165
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29356997
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29226966
90GATA1_19941826_ChIP-Seq_K562_Human1.24527283
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.24451618
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.23550792
93AR_21909140_ChIP-Seq_LNCAP_Human1.23180405
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21740490
95EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20539077
96MYB_26560356_Chip-Seq_TH1_Human1.20381903
97CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19773395
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19557312
99KDM2B_26808549_Chip-Seq_DND41_Human1.19480548
100* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18974950
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17875039
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17129082
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15955285
104* SPI1_23547873_ChIP-Seq_NB4_Human1.15518511
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14474713
106STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14170898
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13635615
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13486194
109P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12957028
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12926716
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12559806
112* PU_27001747_Chip-Seq_BMDM_Mouse1.12024932
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.11415608
114RACK7_27058665_Chip-Seq_MCF-7_Human1.10168700
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.09470559
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09230913
117ATF3_27146783_Chip-Seq_COLON_Human1.09227617
118NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08927848
119* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08879590
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06656865
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06316819
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04734382
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.03994171
124* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03875800
125GATA2_19941826_ChIP-Seq_K562_Human1.03326706
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01190938
127TP53_16413492_ChIP-PET_HCT116_Human1.00250274
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.99604118
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98026190
130* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96502911
131GATA6_25053715_ChIP-Seq_YYC3_Human0.95910604
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95710389
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94822720
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91675761
135GATA4_25053715_ChIP-Seq_YYC3_Human0.91034807
136NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90799426
137TP63_23658742_ChIP-Seq_EP156T_Human0.90736658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.34538307
2MP0006054_spinal_hemorrhage3.16653591
3MP0003300_gastrointestinal_ulcer2.85885160
4MP0005275_abnormal_skin_tensile2.73314702
5MP0004272_abnormal_basement_membrane2.57420918
6MP0003705_abnormal_hypodermis_morpholog2.50547934
7MP0003279_aneurysm2.42234395
8MP0001958_emphysema2.37115259
9MP0003566_abnormal_cell_adhesion2.21822849
10MP0005503_abnormal_tendon_morphology2.16741056
11MP0003950_abnormal_plasma_membrane2.13214287
12MP0003724_increased_susceptibility_to2.07275780
13MP0008004_abnormal_stomach_pH2.06633297
14MP0010352_gastrointestinal_tract_polyps2.01915371
15MP0001879_abnormal_lymphatic_vessel1.96717831
16MP0003191_abnormal_cellular_cholesterol1.94710817
17MP0002166_altered_tumor_susceptibility1.73773057
18MP0005666_abnormal_adipose_tissue1.72830972
19MP0009278_abnormal_bone_marrow1.71329787
20MP0004084_abnormal_cardiac_muscle1.70647213
21MP0003091_abnormal_cell_migration1.67664163
22MP0005023_abnormal_wound_healing1.66322997
23MP0003436_decreased_susceptibility_to1.62467906
24MP0010368_abnormal_lymphatic_system1.62392515
25MP0002877_abnormal_melanocyte_morpholog1.61392343
26MP0005451_abnormal_body_composition1.59206482
27MP0000767_abnormal_smooth_muscle1.57893607
28MP0009840_abnormal_foam_cell1.56469996
29MP0003941_abnormal_skin_development1.54694249
30MP0002060_abnormal_skin_morphology1.53598270
31MP0004130_abnormal_muscle_cell1.50728767
32MP0006138_congestive_heart_failure1.50687363
33MP0001533_abnormal_skeleton_physiology1.45554438
34MP0003045_fibrosis1.45410448
35MP0005623_abnormal_meninges_morphology1.44495244
36MP0002139_abnormal_hepatobiliary_system1.43084158
37MP0010155_abnormal_intestine_physiology1.42010611
38MP0004510_myositis1.41247508
39MP0002933_joint_inflammation1.40694593
40MP0004808_abnormal_hematopoietic_stem1.39732164
41MP0005670_abnormal_white_adipose1.39617489
42MP0004036_abnormal_muscle_relaxation1.39255127
43MP0002396_abnormal_hematopoietic_system1.37895959
44MP0004947_skin_inflammation1.37517573
45MP0000858_altered_metastatic_potential1.35988471
46MP0003828_pulmonary_edema1.33913363
47MP0003303_peritoneal_inflammation1.33399423
48MP0000751_myopathy1.31817250
49MP0005257_abnormal_intraocular_pressure1.31221487
50MP0002998_abnormal_bone_remodeling1.28832509
51MP0001835_abnormal_antigen_presentation1.28528054
52MP0005375_adipose_tissue_phenotype1.28455462
53MP0002006_tumorigenesis1.28401596
54MP0003868_abnormal_feces_composition1.28312809
55MP0000685_abnormal_immune_system1.27698539
56MP0005360_urolithiasis1.26749148
57MP0009384_cardiac_valve_regurgitation1.26322425
58MP0003448_altered_tumor_morphology1.25411597
59MP0000733_abnormal_muscle_development1.22538540
60MP0001661_extended_life_span1.22278655
61MP0000490_abnormal_crypts_of1.22152044
62MP0005076_abnormal_cell_differentiation1.21150222
63MP0004233_abnormal_muscle_weight1.18783311
64MP0002148_abnormal_hypersensitivity_rea1.15433087
65MP0005390_skeleton_phenotype1.14446680
66MP0002419_abnormal_innate_immunity1.14387910
67MP0005000_abnormal_immune_tolerance1.12692247
68MP0002452_abnormal_antigen_presenting1.10633635
69MP0002971_abnormal_brown_adipose1.10167189
70MP0001790_abnormal_immune_system1.08826229
71MP0005387_immune_system_phenotype1.08826229
72MP0005365_abnormal_bile_salt1.07411232
73MP0005397_hematopoietic_system_phenotyp1.07183131
74MP0001545_abnormal_hematopoietic_system1.07183131
75MP0005174_abnormal_tail_pigmentation1.06835031
76MP0004087_abnormal_muscle_fiber1.05964999
77MP0005058_abnormal_lysosome_morphology1.05500002
78MP0000343_altered_response_to1.05218913
79MP0002405_respiratory_system_inflammati1.05155105
80MP0005165_increased_susceptibility_to1.04570955
81MP0005464_abnormal_platelet_physiology1.04547564
82MP0010234_abnormal_vibrissa_follicle1.03328040
83MP0009785_altered_susceptibility_to1.02990858
84MP0000465_gastrointestinal_hemorrhage1.01823676
85MP0002896_abnormal_bone_mineralization1.01796674
86MP0005508_abnormal_skeleton_morphology1.01507654
87MP0008260_abnormal_autophagy0.99498350
88MP0005025_abnormal_response_to0.99143304
89MP0000249_abnormal_blood_vessel0.98024567
90MP0009379_abnormal_foot_pigmentation0.94256177
91MP0002420_abnormal_adaptive_immunity0.93689286
92MP0001819_abnormal_immune_cell0.93319046
93MP0003795_abnormal_bone_structure0.93301117
94MP0004264_abnormal_extraembryonic_tissu0.93011327
95MP0001800_abnormal_humoral_immune0.92808632
96MP0000569_abnormal_digit_pigmentation0.91647082
97MP0005164_abnormal_response_to0.89329694
98MP0010329_abnormal_lipoprotein_level0.88830807
99MP0002972_abnormal_cardiac_muscle0.88405341
100MP0010630_abnormal_cardiac_muscle0.88009120
101MP0002723_abnormal_immune_serum0.86638827
102MP0001873_stomach_inflammation0.86389872
103MP0000013_abnormal_adipose_tissue0.86335135
104MP0000537_abnormal_urethra_morphology0.85782645
105MP0001845_abnormal_inflammatory_respons0.85206970
106MP0003183_abnormal_peptide_metabolism0.84811670
107MP0001849_ear_inflammation0.84754897
108MP0000759_abnormal_skeletal_muscle0.84680203
109MP0002796_impaired_skin_barrier0.84496360
110MP0009780_abnormal_chondrocyte_physiolo0.83184191
111MP0001614_abnormal_blood_vessel0.82828153
112MP0008775_abnormal_heart_ventricle0.82393579
113MP0002332_abnormal_exercise_endurance0.82088729
114MP0001243_abnormal_dermal_layer0.81862119
115MP0001666_abnormal_nutrient_absorption0.81683452
116MP0003656_abnormal_erythrocyte_physiolo0.80618213
117MP0003453_abnormal_keratinocyte_physiol0.80096630
118MP0005595_abnormal_vascular_smooth0.79806525
119MP0003866_abnormal_defecation0.79700965
120MP0002009_preneoplasia0.79219711
121MP0002295_abnormal_pulmonary_circulatio0.79081139
122MP0002925_abnormal_cardiovascular_devel0.78344144
123MP0001851_eye_inflammation0.76583962
124MP0002113_abnormal_skeleton_development0.76542409
125MP0003763_abnormal_thymus_physiology0.76239691
126MP0009333_abnormal_splenocyte_physiolog0.74882629
127MP0002168_other_aberrant_phenotype0.74530541
128MP0002398_abnormal_bone_marrow0.74252817
129MP0000477_abnormal_intestine_morphology0.73718757
130MP0009115_abnormal_fat_cell0.72921954
131MP0000747_muscle_weakness0.72219549
132MP0005085_abnormal_gallbladder_physiolo0.72062240
133MP0002128_abnormal_blood_circulation0.71949655
134MP0005620_abnormal_muscle_contractility0.71927613
135MP0005385_cardiovascular_system_phenoty0.71581864
136MP0001544_abnormal_cardiovascular_syste0.71581864
137MP0000538_abnormal_urinary_bladder0.71019647
138MP0004185_abnormal_adipocyte_glucose0.70553434
139MP0005621_abnormal_cell_physiology0.70422023
140MP0000716_abnormal_immune_system0.70189804
141MP0005330_cardiomyopathy0.70138871
142MP0005409_darkened_coat_color0.68851959
143MP0005501_abnormal_skin_physiology0.67940327
144MP0000749_muscle_degeneration0.67657306
145MP0001915_intracranial_hemorrhage0.66463121
146MP0004883_abnormal_blood_vessel0.65605890
147MP0000003_abnormal_adipose_tissue0.65478103

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.77994827
2Premature rupture of membranes (HP:0001788)4.45341814
3Menorrhagia (HP:0000132)4.18662839
4Ankle contracture (HP:0006466)4.01260647
5Atrophic scars (HP:0001075)3.66479735
6Aortic dissection (HP:0002647)3.63557297
7Aortic aneurysm (HP:0004942)3.59392998
8Cerebral aneurysm (HP:0004944)3.55211577
9Cervical subluxation (HP:0003308)3.48697654
10Prolonged bleeding time (HP:0003010)3.31635159
11Purpura (HP:0000979)3.09559836
12Gingival bleeding (HP:0000225)3.03556333
13Fragile skin (HP:0001030)3.02123064
14Myocardial infarction (HP:0001658)2.99978206
15Hematochezia (HP:0002573)2.98807702
16Shallow orbits (HP:0000586)2.95658715
17Broad metatarsal (HP:0001783)2.78333246
18Increased connective tissue (HP:0009025)2.75916017
19Epistaxis (HP:0000421)2.68658839
20Dilatation of the ascending aorta (HP:0005111)2.68331302
21Vascular tortuosity (HP:0004948)2.67307227
22Increased variability in muscle fiber diameter (HP:0003557)2.61555932
23Peritonitis (HP:0002586)2.60320418
24Mitral stenosis (HP:0001718)2.58764112
25Soft skin (HP:0000977)2.56885625
26Spondylolisthesis (HP:0003302)2.54779797
27Deep venous thrombosis (HP:0002625)2.52663573
28Osteolytic defects of the hand bones (HP:0009699)2.49562273
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.49562273
30Interstitial pulmonary disease (HP:0006530)2.45910537
31Vertebral compression fractures (HP:0002953)2.43677131
32Arterial tortuosity (HP:0005116)2.40978933
33Spinal rigidity (HP:0003306)2.40775160
34Bladder diverticulum (HP:0000015)2.38282111
35Petechiae (HP:0000967)2.36316901
36Distal lower limb amyotrophy (HP:0008944)2.35538854
37Thin bony cortex (HP:0002753)2.31658783
38Syringomyelia (HP:0003396)2.29302352
39Spinal cord lesions (HP:0100561)2.29302352
40Nemaline bodies (HP:0003798)2.26924563
41Wormian bones (HP:0002645)2.26648598
42Abnormal platelet function (HP:0011869)2.25003902
43Impaired platelet aggregation (HP:0003540)2.25003902
44Mitral valve prolapse (HP:0001634)2.24132351
45Autoimmune thrombocytopenia (HP:0001973)2.21541728
46* Abnormality of the common coagulation pathway (HP:0010990)2.18617066
47Right ventricular cardiomyopathy (HP:0011663)2.18017615
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17924164
49Recurrent abscess formation (HP:0002722)2.17489555
50Broad face (HP:0000283)2.16198193
51Distal lower limb muscle weakness (HP:0009053)2.15336632
52Spontaneous hematomas (HP:0007420)2.14905939
53Type 1 muscle fiber predominance (HP:0003803)2.14293305
54Muscle fiber inclusion bodies (HP:0100299)2.11788691
55Mildly elevated creatine phosphokinase (HP:0008180)2.11533018
56Mitral regurgitation (HP:0001653)2.11334628
57Abnormality of complement system (HP:0005339)2.09701112
58Increased density of long bones (HP:0006392)2.07563230
59Wrist flexion contracture (HP:0001239)2.06247707
60Complement deficiency (HP:0004431)2.05706202
61Exercise-induced myalgia (HP:0003738)2.02884663
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00118649
63Cardiovascular calcification (HP:0011915)1.99250330
64Striae distensae (HP:0001065)1.99076850
65Aneurysm (HP:0002617)1.98610778
66Flat acetabular roof (HP:0003180)1.98423270
67Xanthomatosis (HP:0000991)1.97988494
68Joint hemorrhage (HP:0005261)1.97055139
69Esophageal varix (HP:0002040)1.95862020
70Conjunctival telangiectasia (HP:0000524)1.93327076
71Vacuolated lymphocytes (HP:0001922)1.92393405
72Hemorrhage of the eye (HP:0011885)1.92030295
73Milia (HP:0001056)1.91972685
74Follicular hyperkeratosis (HP:0007502)1.91647734
75Hyperlipoproteinemia (HP:0010980)1.91201990
76Eczematoid dermatitis (HP:0000976)1.91026154
77Asymmetric septal hypertrophy (HP:0001670)1.90762142
78Aplasia cutis congenita (HP:0001057)1.90554924
79Back pain (HP:0003418)1.89856154
80Ankyloglossia (HP:0010296)1.89509728
81Blue sclerae (HP:0000592)1.89502530
82Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89037418
83Short nail (HP:0001799)1.87038233
84Mucopolysacchariduria (HP:0008155)1.86583231
85Urinary glycosaminoglycan excretion (HP:0003541)1.86583231
86Bicuspid aortic valve (HP:0001647)1.86540213
87Abnormal delivery (HP:0001787)1.85474818
88Asymmetry of the thorax (HP:0001555)1.85181976
89Cellulitis (HP:0100658)1.84373640
90Polycythemia (HP:0001901)1.83371143
91Hyporeflexia of lower limbs (HP:0002600)1.83123677
92Systemic lupus erythematosus (HP:0002725)1.82880798
93Mesangial abnormality (HP:0001966)1.82368967
94Radial bowing (HP:0002986)1.81444019
95Subacute progressive viral hepatitis (HP:0006572)1.81334932
96Abnormality of the nasal mucosa (HP:0000433)1.80555893
97Increased cerebral lipofuscin (HP:0011813)1.80279024
98Myositis (HP:0100614)1.79878317
99Bruising susceptibility (HP:0000978)1.79774018
100Rectal prolapse (HP:0002035)1.79033833
101Round ear (HP:0100830)1.76580360
102Elbow flexion contracture (HP:0002987)1.76407402
103Amyloidosis (HP:0011034)1.75650708
104Ureteral obstruction (HP:0006000)1.75515437
105Abnormality of oral frenula (HP:0000190)1.74767933
106Knee flexion contracture (HP:0006380)1.74151684
107Abnormality of the peritoneum (HP:0002585)1.73968166
108Centrally nucleated skeletal muscle fibers (HP:0003687)1.73520324
109Hypoplasia of the iris (HP:0007676)1.73275286
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73052345
111Abnormality of carpal bone ossification (HP:0006257)1.72865238
112Papillary thyroid carcinoma (HP:0002895)1.72740235
113Dysostosis multiplex (HP:0000943)1.72733442
114Abnormality of the neuromuscular junction (HP:0003398)1.71381434
115Fatigable weakness (HP:0003473)1.71381434
116Vascular calcification (HP:0004934)1.70575678
117Abnormality of the Achilles tendon (HP:0005109)1.70495480
118Genu recurvatum (HP:0002816)1.70234369
119Tetraparesis (HP:0002273)1.69865997
120Elevated erythrocyte sedimentation rate (HP:0003565)1.68655327
121Abnormal ossification of hand bones (HP:0005921)1.68492968
122Hypercholesterolemia (HP:0003124)1.68371648
123Skin nodule (HP:0200036)1.68330901
124Abnormality of polysaccharide metabolism (HP:0011012)1.68006737
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68006737
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68006737
127Muscle fiber splitting (HP:0003555)1.67547038
128Camptodactyly of toe (HP:0001836)1.66770790
129Abnormality of the acetabulum (HP:0003170)1.66042144
130Hypoalphalipoproteinemia (HP:0003233)1.65992911
131Ureteral stenosis (HP:0000071)1.64764565
132Persistence of primary teeth (HP:0006335)1.64520565
133Thoracolumbar scoliosis (HP:0002944)1.64403078
134Aortic regurgitation (HP:0001659)1.63893780
135Bowel diverticulosis (HP:0005222)1.63768718
136Neonatal short-limb short stature (HP:0008921)1.63556110
137Nonimmune hydrops fetalis (HP:0001790)1.63049392
138Abnormality of the calcaneus (HP:0008364)1.62853058
139Abnormality of skeletal muscle fiber size (HP:0012084)1.62819979
140Abnormal platelet volume (HP:0011876)1.61496436
141Lower limb amyotrophy (HP:0007210)1.61239281
142Increased IgE level (HP:0003212)1.59876098
143Easy fatigability (HP:0003388)1.59449469
144Biconcave vertebral bodies (HP:0004586)1.59058626
145Abnormality of skull ossification (HP:0002703)1.58056807
146Tibial bowing (HP:0002982)1.57430662
147Recurrent viral infections (HP:0004429)1.57222368
148Ulnar bowing (HP:0003031)1.56969837
149Overgrowth (HP:0001548)1.56932909
150Insidious onset (HP:0003587)1.56652479
151Termporal pattern (HP:0011008)1.56652479
152Joint stiffness (HP:0001387)1.56290246
153Joint laxity (HP:0001388)1.56184185
154Delayed closure of the anterior fontanelle (HP:0001476)1.55092245
155Increased mean platelet volume (HP:0011877)1.54630013
156Craniofacial hyperostosis (HP:0004493)1.53829611
157Hypothermia (HP:0002045)1.53759308
158Slender build (HP:0001533)1.53161516
159Increased neuronal autofluorescent lipopigment (HP:0002074)1.52816520
160Reduced subcutaneous adipose tissue (HP:0003758)1.52728368

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB32.81735653
2ERN12.79079481
3TGFBR22.64426484
4TTN2.58553895
5MST42.36891266
6DMPK2.19263642
7NLK2.15410522
8LRRK22.03282770
9PDGFRA1.98659766
10LATS21.92618603
11STK101.87771465
12PRPF4B1.80029942
13PTK61.79585109
14EPHB21.72955960
15CDK121.70430749
16RIPK11.68898969
17TIE11.67438624
18FRK1.64061672
19KIT1.60984387
20PKN21.60421010
21PAK41.58281940
22DDR21.56246626
23TGFBR11.50500023
24TRPM71.47742446
25EEF2K1.46141640
26ICK1.43483357
27EPHA21.41867936
28ZAP701.40715799
29MAP3K101.38038922
30EPHB11.37209440
31EPHA31.35355426
32FLT31.35309123
33MST1R1.35297788
34KDR1.30927688
35JAK31.30264368
36TYK21.28417368
37PIM21.28310683
38TBK11.26989094
39MAP4K11.25455724
40OBSCN1.25241191
41PRKG21.22875529
42PAK21.22854326
43FER1.20183521
44PDGFRB1.18199483
45MAP2K31.17606829
46BLK1.15988337
47STK241.14951417
48MOS1.13283352
49KSR21.12715031
50CDK61.09651344
51CAMKK21.09508493
52RPS6KA41.08727482
53TEC1.07842816
54AKT31.07823271
55IRAK31.06571037
56NME21.06152887
57CDC42BPA1.05465317
58NEK91.04603964
59PTK21.03187677
60FGFR41.01799319
61RIPK41.01539198
62FGFR31.00693281
63ITK0.99822669
64CAMK1D0.99693575
65RET0.97961652
66SIK10.96615875
67MAP3K60.96613768
68CSK0.96519128
69TNIK0.96117216
70JAK10.95312528
71MAP3K20.95033450
72MATK0.94271971
73MELK0.94088365
74MAP3K130.93613770
75MAP3K140.93480897
76NUAK10.93372561
77CDK90.90707360
78PDPK10.89015690
79BMPR20.87614224
80NTRK10.87346504
81IKBKB0.86099247
82CSF1R0.85696056
83BMX0.84373178
84LATS10.80745276
85IRAK40.80734727
86MAP3K70.79794268
87ERBB40.79056676
88CHUK0.78124282
89PRKAA20.77625583
90FGR0.77090532
91EIF2AK10.76494601
92SGK30.76381221
93HCK0.75206782
94BTK0.73468623
95MAP2K20.73026478
96PRKD20.71995662
97ILK0.67322604
98ARAF0.66511083
99PTK2B0.66503044
100STK30.66376544
101MAP3K30.64342801
102STK380.64321419
103PIK3CG0.64063046
104MAPKAPK30.64010348
105TAOK20.62451409
106HIPK20.62361821
107STK38L0.62341826
108SMG10.62246305
109PIM10.61976367
110MET0.61634222
111TAOK30.61213535
112IKBKE0.61204594
113MAP3K10.60880434
114GSK3A0.59716841
115SCYL20.57853261
116RPS6KB20.57154483
117BRSK20.56221271
118LCK0.53663759
119PDK10.52683552
120MTOR0.52376086
121MAPK110.51022662
122CLK10.50782662
123JAK20.49345314
124PRKD10.49154379
125CAMK1G0.48992152
126BRD40.48544613
127MAPK70.48296836
128TESK10.47756778
129MAP2K10.47495815
130YES10.47187288
131LMTK20.47055382
132IGF1R0.46638501
133KSR10.45556010
134MAPKAPK20.44107554
135GRK60.43938127
136MYLK0.42704808
137ABL20.42605342
138DYRK1B0.42466308

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.13411057
2Complement and coagulation cascades_Homo sapiens_hsa046102.11313566
3Leishmaniasis_Homo sapiens_hsa051401.86976840
4Renin-angiotensin system_Homo sapiens_hsa046141.82457223
5Leukocyte transendothelial migration_Homo sapiens_hsa046701.82342168
6Focal adhesion_Homo sapiens_hsa045101.82305615
7Adherens junction_Homo sapiens_hsa045201.81439175
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.81358101
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78144141
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.72786119
11Protein digestion and absorption_Homo sapiens_hsa049741.68650228
12Small cell lung cancer_Homo sapiens_hsa052221.65573425
13PPAR signaling pathway_Homo sapiens_hsa033201.63089759
14Malaria_Homo sapiens_hsa051441.58662648
15Toxoplasmosis_Homo sapiens_hsa051451.56188781
16Thyroid cancer_Homo sapiens_hsa052161.54936442
17Osteoclast differentiation_Homo sapiens_hsa043801.54228802
18Proteoglycans in cancer_Homo sapiens_hsa052051.49674952
19Chronic myeloid leukemia_Homo sapiens_hsa052201.48988030
20Hematopoietic cell lineage_Homo sapiens_hsa046401.48306973
21Other glycan degradation_Homo sapiens_hsa005111.43606117
22Amoebiasis_Homo sapiens_hsa051461.43412563
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.42443363
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36094877
25Shigellosis_Homo sapiens_hsa051311.35963091
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33390441
27TNF signaling pathway_Homo sapiens_hsa046681.31680279
28Antigen processing and presentation_Homo sapiens_hsa046121.30860708
29Pancreatic cancer_Homo sapiens_hsa052121.28733863
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25161058
31Measles_Homo sapiens_hsa051621.24848875
32Platelet activation_Homo sapiens_hsa046111.24221528
33Pertussis_Homo sapiens_hsa051331.22715001
34MicroRNAs in cancer_Homo sapiens_hsa052061.21237294
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20849287
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18283617
37Viral myocarditis_Homo sapiens_hsa054161.18072147
38Acute myeloid leukemia_Homo sapiens_hsa052211.15306171
39Apoptosis_Homo sapiens_hsa042101.15052961
40Bladder cancer_Homo sapiens_hsa052191.14107289
41Renal cell carcinoma_Homo sapiens_hsa052111.13040516
42Salmonella infection_Homo sapiens_hsa051321.12162691
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.11593765
44Lysosome_Homo sapiens_hsa041421.11348289
45Caffeine metabolism_Homo sapiens_hsa002321.09043581
46Starch and sucrose metabolism_Homo sapiens_hsa005001.08830091
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.06855130
48B cell receptor signaling pathway_Homo sapiens_hsa046621.05381073
49Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05321588
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04786230
51Hepatitis B_Homo sapiens_hsa051611.04347662
52Tuberculosis_Homo sapiens_hsa051521.02229776
53Prostate cancer_Homo sapiens_hsa052151.00869894
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99485641
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98140797
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.96636557
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96128534
58Primary immunodeficiency_Homo sapiens_hsa053400.95807568
59Notch signaling pathway_Homo sapiens_hsa043300.95277996
60Legionellosis_Homo sapiens_hsa051340.95145922
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94907515
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93970769
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93878378
64PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93358034
65Mineral absorption_Homo sapiens_hsa049780.93078979
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92165573
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.91693117
68Insulin signaling pathway_Homo sapiens_hsa049100.91256349
69N-Glycan biosynthesis_Homo sapiens_hsa005100.89718589
70Pathways in cancer_Homo sapiens_hsa052000.88765257
71Influenza A_Homo sapiens_hsa051640.88730687
72Pentose phosphate pathway_Homo sapiens_hsa000300.85533616
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84927905
74Colorectal cancer_Homo sapiens_hsa052100.84335752
75Phenylalanine metabolism_Homo sapiens_hsa003600.84186331
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82766702
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.82518071
78Phagosome_Homo sapiens_hsa041450.81876413
79Vitamin digestion and absorption_Homo sapiens_hsa049770.81576800
80Prion diseases_Homo sapiens_hsa050200.81349886
81TGF-beta signaling pathway_Homo sapiens_hsa043500.80844712
82Fatty acid biosynthesis_Homo sapiens_hsa000610.80808377
83Sphingolipid metabolism_Homo sapiens_hsa006000.80503539
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80247818
85Endometrial cancer_Homo sapiens_hsa052130.79914440
86HTLV-I infection_Homo sapiens_hsa051660.79796786
87Hepatitis C_Homo sapiens_hsa051600.77279293
88Glioma_Homo sapiens_hsa052140.77250765
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77180127
90p53 signaling pathway_Homo sapiens_hsa041150.77142115
91T cell receptor signaling pathway_Homo sapiens_hsa046600.77111171
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75785739
93Herpes simplex infection_Homo sapiens_hsa051680.75730338
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75674715
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75187453
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75088259
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74747455
98Fat digestion and absorption_Homo sapiens_hsa049750.74311824
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.73100703
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73008423
101Hippo signaling pathway_Homo sapiens_hsa043900.71971762
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70323598
103Viral carcinogenesis_Homo sapiens_hsa052030.69181253
104Rap1 signaling pathway_Homo sapiens_hsa040150.68624132
105Fatty acid degradation_Homo sapiens_hsa000710.68009390
106Melanoma_Homo sapiens_hsa052180.66878327
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66057841
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66003220
109Chemokine signaling pathway_Homo sapiens_hsa040620.65844045
110Bile secretion_Homo sapiens_hsa049760.64842141
111AMPK signaling pathway_Homo sapiens_hsa041520.64274148
112Basal cell carcinoma_Homo sapiens_hsa052170.63378602
113Prolactin signaling pathway_Homo sapiens_hsa049170.63162853
114Endocytosis_Homo sapiens_hsa041440.62257885
115Gap junction_Homo sapiens_hsa045400.61269496
116HIF-1 signaling pathway_Homo sapiens_hsa040660.60866906
117Dilated cardiomyopathy_Homo sapiens_hsa054140.59790908
118Insulin resistance_Homo sapiens_hsa049310.59246897
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59076969
120Galactose metabolism_Homo sapiens_hsa000520.58326752
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.57033562
122Choline metabolism in cancer_Homo sapiens_hsa052310.56900758
123VEGF signaling pathway_Homo sapiens_hsa043700.56512078
124Arginine biosynthesis_Homo sapiens_hsa002200.56502450
125ErbB signaling pathway_Homo sapiens_hsa040120.55636557
126Glycerolipid metabolism_Homo sapiens_hsa005610.53535098
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52654983
128Inositol phosphate metabolism_Homo sapiens_hsa005620.51558735
129Staphylococcus aureus infection_Homo sapiens_hsa051500.51051955
130Non-small cell lung cancer_Homo sapiens_hsa052230.50628741
131FoxO signaling pathway_Homo sapiens_hsa040680.50231313
132Tight junction_Homo sapiens_hsa045300.49467773
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49056583
134mTOR signaling pathway_Homo sapiens_hsa041500.49048528

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