ANO7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of gastrointestinal epithelium (GO:0030277)9.65480541
2intestinal absorption (GO:0050892)9.02700408
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.64288890
4epithelial structure maintenance (GO:0010669)7.46537425
5intestinal cholesterol absorption (GO:0030299)7.15185329
6endothelial cell chemotaxis (GO:0035767)6.77432154
7desmosome organization (GO:0002934)6.62305156
8angiotensin maturation (GO:0002003)6.53602590
9digestion (GO:0007586)6.46843701
10digestive system process (GO:0022600)6.22188996
11iron ion import (GO:0097286)6.08398356
12branching involved in prostate gland morphogenesis (GO:0060442)5.62596169
13O-glycan processing (GO:0016266)5.52164855
143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.18139415
15purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.18139415
16virion attachment to host cell (GO:0019062)5.10500271
17adhesion of symbiont to host cell (GO:0044650)5.10500271
18intestinal epithelial cell development (GO:0060576)5.04295410
19sulfation (GO:0051923)4.81812997
20UDP-N-acetylglucosamine metabolic process (GO:0006047)4.79256005
21actin filament depolymerization (GO:0030042)4.55830421
22diol metabolic process (GO:0034311)4.53752832
23vitamin A metabolic process (GO:0006776)4.40202317
24sphingosine metabolic process (GO:0006670)4.39878128
25hemidesmosome assembly (GO:0031581)4.27730283
26prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.26178433
27regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.24007009
28negative regulation of B cell apoptotic process (GO:0002903)4.21993171
29sphingoid metabolic process (GO:0046519)4.20502278
30artery development (GO:0060840)4.14842306
31import into cell (GO:0098657)4.11291722
32diacylglycerol metabolic process (GO:0046339)4.10188053
33regulation of proton transport (GO:0010155)4.09306064
34lung lobe morphogenesis (GO:0060463)3.98255210
35adhesion of symbiont to host (GO:0044406)3.97798618
36lung vasculature development (GO:0060426)3.96220349
37negative regulation of protein localization to cell surface (GO:2000009)3.96115710
38biotin metabolic process (GO:0006768)3.94305766
39glandular epithelial cell differentiation (GO:0002067)3.90613706
40negative regulation of digestive system process (GO:0060457)3.86589476
41ventricular cardiac muscle cell action potential (GO:0086005)3.84492532
42protein O-linked glycosylation (GO:0006493)3.83783021
43sulfate transmembrane transport (GO:1902358)3.77770430
44flavonoid metabolic process (GO:0009812)3.77267247
45negative regulation of B cell mediated immunity (GO:0002713)3.76273587
46negative regulation of immunoglobulin mediated immune response (GO:0002890)3.76273587
47protein autoprocessing (GO:0016540)3.75450560
48thyroid hormone metabolic process (GO:0042403)3.73166520
49fibroblast migration (GO:0010761)3.69910142
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68583570
51positive regulation of protein kinase C signaling (GO:0090037)3.67766605
52regulation of guanylate cyclase activity (GO:0031282)3.65564385
53regulation of T-helper 2 cell differentiation (GO:0045628)3.63185084
54carnitine transmembrane transport (GO:1902603)3.53913021
55phosphatidylinositol acyl-chain remodeling (GO:0036149)3.52794252
56antibacterial humoral response (GO:0019731)3.49719020
57lung secretory cell differentiation (GO:0061140)3.46302232
58extracellular matrix assembly (GO:0085029)3.46000411
59negative regulation of sodium ion transport (GO:0010766)3.45038429
60peptide hormone processing (GO:0016486)3.44620123
61L-fucose metabolic process (GO:0042354)3.43779351
62L-fucose catabolic process (GO:0042355)3.43779351
63fucose catabolic process (GO:0019317)3.43779351
64carnitine transport (GO:0015879)3.43227884
65amino-acid betaine transport (GO:0015838)3.43227884
66endocardial cushion development (GO:0003197)3.41666855
67antimicrobial humoral response (GO:0019730)3.37473669
68toxin transport (GO:1901998)3.37303196
69regulation of memory T cell differentiation (GO:0043380)3.35630963
70positive regulation of fatty acid oxidation (GO:0046321)3.35294183
71exocrine pancreas development (GO:0031017)3.34795149
72positive regulation of steroid hormone secretion (GO:2000833)3.34680709
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.32845773
74regulation of water loss via skin (GO:0033561)3.30340419
75regulation of germinal center formation (GO:0002634)3.28314969
76phosphatidylserine acyl-chain remodeling (GO:0036150)3.20349586
77positive regulation of glycogen biosynthetic process (GO:0045725)3.19841411
78regulation of hippo signaling (GO:0035330)3.19695110
79quaternary ammonium group transport (GO:0015697)3.19385789
80regulation of fatty acid oxidation (GO:0046320)3.18715194
81very-low-density lipoprotein particle assembly (GO:0034379)3.18136994
82nucleotide-sugar biosynthetic process (GO:0009226)3.17172022
83regulation of phospholipase A2 activity (GO:0032429)3.15124552
84peptide catabolic process (GO:0043171)3.15079287
85glycerol metabolic process (GO:0006071)3.14091009
86epoxygenase P450 pathway (GO:0019373)3.13800365
87regulation of fatty acid beta-oxidation (GO:0031998)3.12112182
88glucose 6-phosphate metabolic process (GO:0051156)3.11968889
89cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11543499
90response to hepatocyte growth factor (GO:0035728)3.11543499
91extracellular fibril organization (GO:0043206)3.11527765
92regulation of heart rate by cardiac conduction (GO:0086091)3.11526902
93positive regulation of glycolytic process (GO:0045821)3.09922700
94negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08960618
95negative regulation of T-helper cell differentiation (GO:0045623)3.08960618
96phospholipid efflux (GO:0033700)3.07632344
97cell communication involved in cardiac conduction (GO:0086065)3.05586858
98icosanoid transport (GO:0071715)3.05505648
99fatty acid derivative transport (GO:1901571)3.05505648
100regulation of bile acid biosynthetic process (GO:0070857)3.05149161
101regulation of cholesterol homeostasis (GO:2000188)3.03721701
102fructose metabolic process (GO:0006000)3.02888293
103lung epithelial cell differentiation (GO:0060487)3.02525210
104hormone catabolic process (GO:0042447)3.02034282
105sperm capacitation (GO:0048240)3.01285244
106positive regulation of chemokine secretion (GO:0090197)3.00756070
107cardiac conduction (GO:0061337)3.00147860
108carnitine shuttle (GO:0006853)2.99661134
109regulation of pH (GO:0006885)2.99487939
110filopodium assembly (GO:0046847)2.99353393
111epithelial cell-cell adhesion (GO:0090136)2.96815634
112drug transport (GO:0015893)2.93729184
113prostate gland epithelium morphogenesis (GO:0060740)2.93453452
114regulation of glycogen (starch) synthase activity (GO:2000465)2.93036232
115drug transmembrane transport (GO:0006855)2.92381628
116regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.92236570
117steroid hormone mediated signaling pathway (GO:0043401)2.91383814
118copper ion transport (GO:0006825)2.91340675
119arachidonic acid secretion (GO:0050482)2.90311593
120icosanoid secretion (GO:0032309)2.90311593
121intermediate filament organization (GO:0045109)2.90174950
122fatty acid transmembrane transport (GO:1902001)2.89601465
123drug catabolic process (GO:0042737)2.89497852
124mitotic cell cycle arrest (GO:0071850)2.88752217
125negative regulation of fatty acid transport (GO:2000192)2.88447363
126negative regulation of hormone metabolic process (GO:0032351)2.88170746
127negative regulation of hormone biosynthetic process (GO:0032353)2.88170746
128bicarbonate transport (GO:0015701)2.88082475
129sulfur compound transport (GO:0072348)2.88054348
130lung cell differentiation (GO:0060479)2.87877940
131cell migration involved in sprouting angiogenesis (GO:0002042)2.87639820
132regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.87584137
133drinking behavior (GO:0042756)2.87250188
134smooth muscle contraction (GO:0006939)2.86801390
135urinary tract smooth muscle contraction (GO:0014848)2.85551565
136N-glycan processing (GO:0006491)2.85440762
137sulfate transport (GO:0008272)2.84631972
138GDP-mannose metabolic process (GO:0019673)2.83812980
139keratinocyte proliferation (GO:0043616)2.83231533
140negative regulation of translation, ncRNA-mediated (GO:0040033)2.83215485
141regulation of translation, ncRNA-mediated (GO:0045974)2.83215485
142negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83215485
143glutathione derivative biosynthetic process (GO:1901687)2.82167493
144glutathione derivative metabolic process (GO:1901685)2.82167493
145positive regulation of glycogen metabolic process (GO:0070875)2.81856707
146sphingomyelin metabolic process (GO:0006684)2.80022069
147regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.79372535
148membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79276430
149epithelial cell maturation (GO:0002070)2.78670005
150vitamin transmembrane transport (GO:0035461)2.78314938
151columnar/cuboidal epithelial cell development (GO:0002066)2.77917832
152homocysteine metabolic process (GO:0050667)2.77819101
153phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.76291563
154innate immune response in mucosa (GO:0002227)2.76052667
155fibril organization (GO:0097435)2.75533949
156regulation of viral entry into host cell (GO:0046596)2.75281652
157regulation of chemokine secretion (GO:0090196)2.74618153
158negative regulation of cholesterol transport (GO:0032375)2.73552230
159negative regulation of sterol transport (GO:0032372)2.73552230
160retina homeostasis (GO:0001895)2.73264462
161regulation of cholesterol metabolic process (GO:0090181)2.72137523
162linoleic acid metabolic process (GO:0043651)2.71966651
163antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71654069
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71654069
165alditol metabolic process (GO:0019400)2.70971740
166growth hormone secretion (GO:0030252)2.69182597
167post-embryonic morphogenesis (GO:0009886)2.68954224
168cGMP-mediated signaling (GO:0019934)2.67819010
169regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.67517474
170endocrine process (GO:0050886)2.67517474
171regulation of systemic arterial blood pressure by hormone (GO:0001990)2.67517474
172positive regulation of guanylate cyclase activity (GO:0031284)2.65830874
173establishment of protein localization to Golgi (GO:0072600)2.65566822
174transepithelial transport (GO:0070633)2.65211144
175interkinetic nuclear migration (GO:0022027)2.63922946
176regulation of pigment cell differentiation (GO:0050932)2.59947184
177glycine transport (GO:0015816)2.59228893
178negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.58491899
179tonic smooth muscle contraction (GO:0014820)2.58089136
180acetyl-CoA metabolic process (GO:0006084)2.54762400
181regulation of establishment or maintenance of cell polarity (GO:0032878)2.54420719
182receptor catabolic process (GO:0032801)2.54325441
183phosphate ion transmembrane transport (GO:0035435)2.52932019
184sequestering of extracellular ligand from receptor (GO:0035581)2.52065494
185negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.50513228
186nephron tubule morphogenesis (GO:0072078)2.50092671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.48462452
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.63910709
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.22756359
4* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.86788878
5GATA4_25053715_ChIP-Seq_YYC3_Human3.03984554
6AR_21909140_ChIP-Seq_LNCAP_Human2.81279687
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71066971
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70393131
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.67464432
10GATA6_25053715_ChIP-Seq_YYC3_Human2.60622977
11SOX2_20726797_ChIP-Seq_SW620_Human2.42143440
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.28472867
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.25504608
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.12815122
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10810634
16* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.09070987
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99312242
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.96660946
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94297442
20PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94008013
21RUNX1_27514584_Chip-Seq_MCF-7_Human1.90342002
22KLF5_25053715_ChIP-Seq_YYC3_Human1.86960978
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86105530
24P63_26484246_Chip-Seq_KERATINOCYTES_Human1.85434863
25RACK7_27058665_Chip-Seq_MCF-7_Human1.82989162
26FOXA1_25552417_ChIP-Seq_VCAP_Human1.82646413
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.81442606
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75101201
29AR_21572438_ChIP-Seq_LNCaP_Human1.74183146
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72237753
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.71866968
32ZNF263_19887448_ChIP-Seq_K562_Human1.71719080
33ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69032542
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.68867362
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67197501
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65358787
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64670254
38* LXR_22292898_ChIP-Seq_THP-1_Human1.63822026
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.61070261
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58530605
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55317457
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54833260
43VDR_22108803_ChIP-Seq_LS180_Human1.52458209
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51696015
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49473890
46DROSHA_22980978_ChIP-Seq_HELA_Human1.48455470
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46061032
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.44474993
49ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42895232
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42578837
51ATF3_27146783_Chip-Seq_COLON_Human1.41829986
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35853430
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.33656787
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25452186
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25183252
56TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.24652245
57TP63_22573176_ChIP-Seq_HFKS_Human1.23444783
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23179924
59ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.21706697
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18213565
61ERA_21632823_ChIP-Seq_H3396_Human1.15946017
62CREB1_26743006_Chip-Seq_LNCaP_Human1.15919757
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15527425
64EGR1_19032775_ChIP-ChIP_M12_Human1.14972225
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14890771
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12944529
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12806482
68CHD1_26751641_Chip-Seq_LNCaP_Human1.12664504
69SMC4_20622854_ChIP-Seq_HELA_Human1.11285103
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10861165
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10327111
72GATA3_24758297_ChIP-Seq_MCF-7_Human1.09260131
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07779106
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07653618
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.07612456
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06647636
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05399789
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04454404
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04454404
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03414684
81BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02802248
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01787138
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.01408163
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01274183
85RXR_22108803_ChIP-Seq_LS180_Human1.01187444
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00305516
87P68_20966046_ChIP-Seq_HELA_Human0.99778209
88SMAD3_21741376_ChIP-Seq_HESCs_Human0.99354901
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.98979970
90ZNF274_21170338_ChIP-Seq_K562_Hela0.98962330
91RXR_22158963_ChIP-Seq_LIVER_Mouse0.98605339
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.98469616
93BCL6_27268052_Chip-Seq_Bcells_Human0.98155465
94OCT4_20526341_ChIP-Seq_ESCs_Human0.97694516
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96897919
96STAT1_20625510_ChIP-Seq_HELA_Human0.95305412
97BCOR_27268052_Chip-Seq_Bcells_Human0.95107440
98* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94192244
99* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93909675
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93882246
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93366679
102CTCF_27219007_Chip-Seq_Bcells_Human0.92644088
103PHF8_20622854_ChIP-Seq_HELA_Human0.92474713
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91276058
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91016537
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90852318
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.90266241
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89915228
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89914966
110GATA2_19941826_ChIP-Seq_K562_Human0.89833109
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89659493
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89602351
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89069009
114P53_21459846_ChIP-Seq_SAOS-2_Human0.88275842
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.87282383
116IRF1_19129219_ChIP-ChIP_H3396_Human0.87217197
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86549806
118* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86526199
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86218787
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85983678
121EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85936480
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.84972198
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.84187834
124VDR_21846776_ChIP-Seq_THP-1_Human0.83316586
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.82369585
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81473712
127E2F1_17053090_ChIP-ChIP_MCF-7_Human0.81387065
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81371089
129SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.81308765
130* OCT1_27270436_Chip-Seq_PROSTATE_Human0.81015136
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.80820408
132AHR_22903824_ChIP-Seq_MCF-7_Human0.80334637
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.79313561
134* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79187453
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.79024335
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78094128
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.76610121
138* HNF4A_19822575_ChIP-Seq_HepG2_Human0.76187605
139FOXA2_19822575_ChIP-Seq_HepG2_Human0.75522731
140CTCF_27219007_Chip-Seq_ERYTHROID_Human0.75475609
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75228033
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74908640
143KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.74861286
144RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71072046
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.69347811
146KDM2B_26808549_Chip-Seq_K562_Human0.68798736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.69741333
2MP0001873_stomach_inflammation4.80072814
3MP0005670_abnormal_white_adipose4.78843469
4MP0001666_abnormal_nutrient_absorption4.58495910
5MP0005360_urolithiasis4.47538906
6MP0010234_abnormal_vibrissa_follicle4.38628080
7MP0001664_abnormal_digestion3.75526428
8MP0004264_abnormal_extraembryonic_tissu3.69709986
9MP0000462_abnormal_digestive_system3.65106001
10MP0000470_abnormal_stomach_morphology2.84436314
11MP0003866_abnormal_defecation2.79865814
12MP0001756_abnormal_urination2.73563417
13MP0005381_digestive/alimentary_phenotyp2.66227482
14MP0001663_abnormal_digestive_system2.56312230
15MP0002796_impaired_skin_barrier2.42615183
16MP0004858_abnormal_nervous_system2.28931063
17MP0005409_darkened_coat_color2.19404254
18MP0000490_abnormal_crypts_of2.15148644
19MP0003183_abnormal_peptide_metabolism2.14664327
20MP0001986_abnormal_taste_sensitivity2.01625133
21MP0010155_abnormal_intestine_physiology1.98051408
22MP0002254_reproductive_system_inflammat1.97430079
23MP0000477_abnormal_intestine_morphology1.90872852
24MP0000230_abnormal_systemic_arterial1.84536144
25MP0002166_altered_tumor_susceptibility1.84141140
26MP0001188_hyperpigmentation1.83811901
27MP0003045_fibrosis1.79292696
28MP0010386_abnormal_urinary_bladder1.77045047
29MP0005085_abnormal_gallbladder_physiolo1.69293749
30MP0003806_abnormal_nucleotide_metabolis1.66157763
31MP0003879_abnormal_hair_cell1.64835649
32MP0003283_abnormal_digestive_organ1.62404931
33MP0005501_abnormal_skin_physiology1.61917102
34MP0003252_abnormal_bile_duct1.60038080
35MP0010678_abnormal_skin_adnexa1.55535433
36MP0003195_calcinosis1.48242778
37MP0002735_abnormal_chemical_nociception1.47551603
38MP0010352_gastrointestinal_tract_polyps1.45110369
39MP0005647_abnormal_sex_gland1.43862942
40MP0008875_abnormal_xenobiotic_pharmacok1.43633291
41MP0004947_skin_inflammation1.42156984
42MP0002138_abnormal_hepatobiliary_system1.40949296
43MP0002876_abnormal_thyroid_physiology1.37576439
44MP0004510_myositis1.35570918
45MP0010329_abnormal_lipoprotein_level1.35011774
46MP0005220_abnormal_exocrine_pancreas1.31450716
47MP0001216_abnormal_epidermal_layer1.31174180
48MP0000538_abnormal_urinary_bladder1.30624468
49MP0000613_abnormal_salivary_gland1.28174473
50MP0005332_abnormal_amino_acid1.27797777
51MP0006054_spinal_hemorrhage1.26379605
52MP0002006_tumorigenesis1.23839656
53MP0002098_abnormal_vibrissa_morphology1.23360115
54MP0005379_endocrine/exocrine_gland_phen1.21373488
55MP0001764_abnormal_homeostasis1.20451840
56MP0005451_abnormal_body_composition1.20420403
57MP0003941_abnormal_skin_development1.19801037
58MP0000678_abnormal_parathyroid_gland1.17853410
59MP0000467_abnormal_esophagus_morphology1.17665530
60MP0009840_abnormal_foam_cell1.17132915
61MP0003718_maternal_effect1.17123326
62MP0005365_abnormal_bile_salt1.16994986
63MP0003705_abnormal_hypodermis_morpholog1.16379736
64MP0003011_delayed_dark_adaptation1.16121314
65MP0001849_ear_inflammation1.15700861
66MP0002060_abnormal_skin_morphology1.10891497
67MP0003136_yellow_coat_color1.10140451
68MP0004019_abnormal_vitamin_homeostasis1.09769966
69MP0001501_abnormal_sleep_pattern1.09483523
70MP0002168_other_aberrant_phenotype1.07122527
71MP0005395_other_phenotype1.06393163
72MP0000383_abnormal_hair_follicle1.06291964
73MP0005330_cardiomyopathy1.05837792
74MP0002736_abnormal_nociception_after1.02100767
75MP0009384_cardiac_valve_regurgitation1.01646617
76MP0001968_abnormal_touch/_nociception1.00528494
77MP0000537_abnormal_urethra_morphology0.99215214
78MP0003453_abnormal_keratinocyte_physiol0.98100571
79MP0003300_gastrointestinal_ulcer0.96729417
80MP0010771_integument_phenotype0.95752396
81MP0008961_abnormal_basal_metabolism0.94726704
82MP0002234_abnormal_pharynx_morphology0.94331453
83MP0005666_abnormal_adipose_tissue0.93221359
84MP0001765_abnormal_ion_homeostasis0.93061967
85MP0004043_abnormal_pH_regulation0.92114884
86MP0005084_abnormal_gallbladder_morpholo0.91604667
87MP0005448_abnormal_energy_balance0.90406933
88MP0005319_abnormal_enzyme/_coenzyme0.90092402
89MP0000465_gastrointestinal_hemorrhage0.89762621
90MP0002822_catalepsy0.88482487
91MP0005174_abnormal_tail_pigmentation0.87656543
92MP0005076_abnormal_cell_differentiation0.86902860
93MP0004147_increased_porphyrin_level0.86813930
94MP0002139_abnormal_hepatobiliary_system0.85821282
95MP0000579_abnormal_nail_morphology0.85508586
96MP0005377_hearing/vestibular/ear_phenot0.84740756
97MP0003878_abnormal_ear_physiology0.84740756
98MP0001485_abnormal_pinna_reflex0.83926450
99MP0009643_abnormal_urine_homeostasis0.82873508
100MP0008057_abnormal_DNA_replication0.82822106
101MP0000432_abnormal_head_morphology0.81370401
102MP0003868_abnormal_feces_composition0.80713075
103MP0005310_abnormal_salivary_gland0.78725694
104MP0001191_abnormal_skin_condition0.78088743
105MP0003315_abnormal_perineum_morphology0.77673668
106MP0002249_abnormal_larynx_morphology0.76522979
107MP0009379_abnormal_foot_pigmentation0.74634551
108MP0005165_increased_susceptibility_to0.74174382
109MP0002909_abnormal_adrenal_gland0.73941972
110MP0005636_abnormal_mineral_homeostasis0.73897637
111MP0005551_abnormal_eye_electrophysiolog0.73400017
112MP0002896_abnormal_bone_mineralization0.72844456
113MP0005167_abnormal_blood-brain_barrier0.71488882
114MP0001845_abnormal_inflammatory_respons0.68880343
115MP0005646_abnormal_pituitary_gland0.67763535
116MP0002160_abnormal_reproductive_system0.66830794
117MP0005275_abnormal_skin_tensile0.66571174
118MP0000427_abnormal_hair_cycle0.65716065
119MP0009115_abnormal_fat_cell0.64664266
120MP0003566_abnormal_cell_adhesion0.64177545
121MP0002078_abnormal_glucose_homeostasis0.64079522
122MP0001270_distended_abdomen0.63133851
123MP0001502_abnormal_circadian_rhythm0.62259393
124MP0005367_renal/urinary_system_phenotyp0.61710667
125MP0000516_abnormal_urinary_system0.61710667
126MP0005375_adipose_tissue_phenotype0.61675629
127MP0002115_abnormal_skeleton_extremities0.61603058
128MP0002148_abnormal_hypersensitivity_rea0.60730972
129MP0009931_abnormal_skin_appearance0.60598549
130MP0000013_abnormal_adipose_tissue0.59086827
131MP0000609_abnormal_liver_physiology0.58500975
132MP0000377_abnormal_hair_follicle0.58369740
133MP0006082_CNS_inflammation0.57148034
134MP0002118_abnormal_lipid_homeostasis0.56845350
135MP0006072_abnormal_retinal_apoptosis0.56497455
136MP0000566_synostosis0.56233483
137MP0001853_heart_inflammation0.55742272
138MP0005166_decreased_susceptibility_to0.55206681
139MP0005266_abnormal_metabolism0.53585186
140MP0002693_abnormal_pancreas_physiology0.51960141
141MP0003123_paternal_imprinting0.50812641
142MP0005464_abnormal_platelet_physiology0.48754465
143MP0003953_abnormal_hormone_level0.42869640
144MP0005083_abnormal_biliary_tract0.42774682
145MP0003436_decreased_susceptibility_to0.42116838
146MP0002089_abnormal_postnatal_growth/wei0.41978992
147MP0000685_abnormal_immune_system0.41892190
148MP0003693_abnormal_embryo_hatching0.41034388
149MP0002136_abnormal_kidney_physiology0.41030793

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)8.67604564
2Ileus (HP:0002595)5.53683292
3Aortic aneurysm (HP:0004942)5.49314501
4Malnutrition (HP:0004395)4.90093941
5Autoimmune thrombocytopenia (HP:0001973)4.39908809
6Abnormal number of erythroid precursors (HP:0012131)4.27557486
7Abnormality of cells of the erythroid lineage (HP:0012130)4.04246958
8Hyperparathyroidism (HP:0000843)4.02851566
9Bronchomalacia (HP:0002780)3.93584461
10Milia (HP:0001056)3.92905683
11Woolly hair (HP:0002224)3.90974796
12Abdominal distention (HP:0003270)3.88806316
13Aortic dissection (HP:0002647)3.87397945
14Atrophic scars (HP:0001075)3.72665798
15Abnormal tarsal ossification (HP:0008369)3.66294540
16Chronic diarrhea (HP:0002028)3.64327166
17Palpitations (HP:0001962)3.62818568
18Neoplasm of the heart (HP:0100544)3.61406515
19Pili torti (HP:0003777)3.56128432
20Upper limb muscle weakness (HP:0003484)3.49690234
21Increased IgE level (HP:0003212)3.45915135
22Plantar hyperkeratosis (HP:0007556)3.44391470
23Hyperventilation (HP:0002883)3.44089513
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38577615
25Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.36995814
26Syncope (HP:0001279)3.34344615
27Hyperglycinuria (HP:0003108)3.29072962
28Genetic anticipation (HP:0003743)3.26897859
29Onycholysis (HP:0001806)3.26841939
30Acanthocytosis (HP:0001927)3.26231636
31Congenital sensorineural hearing impairment (HP:0008527)3.22093456
32Aplasia of the musculature (HP:0100854)3.20105126
33Aortic regurgitation (HP:0001659)3.17241484
34Abnormality of vitamin B metabolism (HP:0004340)3.13200113
35Abnormality of carpal bone ossification (HP:0006257)3.11755107
36Congenital stationary night blindness (HP:0007642)3.10515469
37Conjugated hyperbilirubinemia (HP:0002908)3.10036167
38Intrahepatic cholestasis (HP:0001406)3.08427451
39Ventricular fibrillation (HP:0001663)2.99847852
40Fragile nails (HP:0001808)2.95284123
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.94272152
42Abnormality of the gastric mucosa (HP:0004295)2.93520975
43Hyperactive renin-angiotensin system (HP:0000841)2.88493116
44Fragile skin (HP:0001030)2.86595415
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.86182526
46Abnormal foot bone ossification (HP:0010675)2.85947670
47Abnormality of small intestinal villus morphology (HP:0011472)2.85365383
48Villous atrophy (HP:0011473)2.85365383
49Broad face (HP:0000283)2.83002903
50Pigmentary retinal degeneration (HP:0001146)2.80728889
51Mildly elevated creatine phosphokinase (HP:0008180)2.76831489
52Dehydration (HP:0001944)2.73662382
53Abnormality of the parathyroid morphology (HP:0011766)2.71108096
54Abnormality of the axillary hair (HP:0100134)2.69480007
55Abnormality of secondary sexual hair (HP:0009888)2.69480007
56Hypobetalipoproteinemia (HP:0003563)2.69431858
57Abnormality of vitamin metabolism (HP:0100508)2.69291717
58Hemorrhage of the eye (HP:0011885)2.68631923
59Autoimmune hemolytic anemia (HP:0001890)2.67205617
60Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.66919472
61Abnormal ossification of hand bones (HP:0005921)2.66830989
62Posterior subcapsular cataract (HP:0007787)2.64328741
63Myopathic facies (HP:0002058)2.62079832
64Hydroxyprolinuria (HP:0003080)2.59225085
65Abnormality of proline metabolism (HP:0010907)2.59225085
66Congenital malformation of the right heart (HP:0011723)2.58349494
67Double outlet right ventricle (HP:0001719)2.58349494
68Abnormal hand bone ossification (HP:0010660)2.58144995
69Abnormality of abdominal situs (HP:0011620)2.54819498
70Abdominal situs inversus (HP:0003363)2.54819498
71Gastrointestinal dysmotility (HP:0002579)2.53076395
72Abnormality of glycine metabolism (HP:0010895)2.49879155
73Abnormality of serine family amino acid metabolism (HP:0010894)2.49879155
74Fat malabsorption (HP:0002630)2.49466628
75Dysmetric saccades (HP:0000641)2.46344325
76Abnormality of the nasal septum (HP:0000419)2.46186236
77Flat acetabular roof (HP:0003180)2.44247269
78Palmar hyperkeratosis (HP:0010765)2.43611031
79Decreased circulating renin level (HP:0003351)2.41350974
80Cupped ribs (HP:0000887)2.41068801
81Late onset (HP:0003584)2.40781156
82Abnormality of renin-angiotensin system (HP:0000847)2.40738679
83Symptomatic seizures (HP:0011145)2.38436894
84Palmoplantar hyperkeratosis (HP:0000972)2.35466431
85Abnormality of chloride homeostasis (HP:0011422)2.34763465
86Abnormality of the fingertips (HP:0001211)2.27622123
87Breast hypoplasia (HP:0003187)2.25955141
88Laryngomalacia (HP:0001601)2.25930129
89Hyperglycemia (HP:0003074)2.25693870
90Megaloblastic anemia (HP:0001889)2.25665721
91Clumsiness (HP:0002312)2.24209804
92Hypoplastic nipples (HP:0002557)2.21746430
93Ventricular arrhythmia (HP:0004308)2.21612258
94Abnormality of calcium-phosphate metabolism (HP:0100530)2.20968736
95Rectal prolapse (HP:0002035)2.19492139
96Abnormality of the 1st metacarpal (HP:0010009)2.19412703
97Abnormal hair laboratory examination (HP:0003328)2.19069009
98Sensorimotor neuropathy (HP:0007141)2.18153585
99Ventricular tachycardia (HP:0004756)2.16018170
100Lip pit (HP:0100267)2.15870050
101Potter facies (HP:0002009)2.15667227
102Facial shape deformation (HP:0011334)2.15667227
103Pustule (HP:0200039)2.15453747
104Testicular atrophy (HP:0000029)2.15026932
105Sparse lateral eyebrow (HP:0005338)2.14765949
106Colitis (HP:0002583)2.14177481
107Micronodular cirrhosis (HP:0001413)2.13216763
108Persistence of primary teeth (HP:0006335)2.12603773
109Prolonged QT interval (HP:0001657)2.12560636
110Abnormality of the phalanges of the hallux (HP:0010057)2.11199795
111Thin bony cortex (HP:0002753)2.10897510
112Absent radius (HP:0003974)2.10853458
113Nephrolithiasis (HP:0000787)2.10585524
114Advanced eruption of teeth (HP:0006288)2.08159566
115Ureteral stenosis (HP:0000071)2.07555044
116Aneurysm (HP:0002617)2.07146766
117Abnormal glucose tolerance (HP:0001952)2.06891371
118Fatigable weakness (HP:0003473)2.05895482
119Abnormality of the neuromuscular junction (HP:0003398)2.05895482
120Abnormal blistering of the skin (HP:0008066)2.05717646
121Broad metatarsal (HP:0001783)2.05538856
122Hypoplasia of dental enamel (HP:0006297)2.05254790
123Short humerus (HP:0005792)2.04511571
124Ureteral obstruction (HP:0006000)2.04105965
125Aplasia/Hypoplasia of the tibia (HP:0005772)2.02274148
126Tented upper lip vermilion (HP:0010804)2.01101815
127Ankyloglossia (HP:0010296)1.99699930
128Flattened epiphyses (HP:0003071)1.98724457
129Goiter (HP:0000853)1.98127405
130Gaze-evoked nystagmus (HP:0000640)1.97162373
131Hyperphosphatemia (HP:0002905)1.96675573
132Choanal stenosis (HP:0000452)1.96535765
133Renal tubular acidosis (HP:0001947)1.95733328
134Metabolic alkalosis (HP:0200114)1.95128578
135Tracheomalacia (HP:0002779)1.94608384
136Poikilocytosis (HP:0004447)1.93316766
137Curly hair (HP:0002212)1.92192115
138Prolonged partial thromboplastin time (HP:0003645)1.91381861
139Confusion (HP:0001289)1.91238191
140IgM deficiency (HP:0002850)1.90773311
141Aplasia involving forearm bones (HP:0009822)1.90701872
142Absent forearm bone (HP:0003953)1.90701872
143Conjunctival hamartoma (HP:0100780)1.90509919
144Cheilitis (HP:0100825)1.90402621
145Microretrognathia (HP:0000308)1.90046487
146Anal stenosis (HP:0002025)1.89915567
147Urethral obstruction (HP:0000796)1.85537158
148Short 1st metacarpal (HP:0010034)1.85121172
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85121172
150Hyperinsulinemic hypoglycemia (HP:0000825)1.84966280
151Petechiae (HP:0000967)1.84873165
152Amelogenesis imperfecta (HP:0000705)1.84699123
153Nail dystrophy (HP:0008404)1.83769264
154Intestinal fistula (HP:0100819)1.83657590
155Hypoplasia of the ulna (HP:0003022)1.81637647
156Shawl scrotum (HP:0000049)1.79952982
157Abnormality of purine metabolism (HP:0004352)1.79907510
158Hypercortisolism (HP:0001578)1.79334070
159Agitation (HP:0000713)1.78455526
160Widely patent fontanelles and sutures (HP:0004492)1.77654571
161Aplasia/hypoplasia of the femur (HP:0005613)1.77165137
162Short phalanx of the thumb (HP:0009660)1.75692238
163Truncus arteriosus (HP:0001660)1.74988209
164Insulin-resistant diabetes mellitus (HP:0000831)1.74764604
165Aplasia/hypoplasia of the humerus (HP:0006507)1.74579481
166Insulin resistance (HP:0000855)1.74483660
167Generalized hypopigmentation of hair (HP:0011358)1.73418220
16811 pairs of ribs (HP:0000878)1.73358049
169Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73264371
170Cervical subluxation (HP:0003308)1.72005994
171Hyperkalemia (HP:0002153)1.71298571
172Alkalosis (HP:0001948)1.71074477
173Shallow orbits (HP:0000586)1.69797381
174Skin nodule (HP:0200036)1.69777685
175Proximal tubulopathy (HP:0000114)1.69576020
176Abnormality of potassium homeostasis (HP:0011042)1.68641623
177Abnormality of the fibula (HP:0002991)1.67142888

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.44648788
2MST44.10661479
3FRK3.91527796
4MAP3K93.53617125
5ERBB43.36331443
6ACVR1B3.32035792
7MAPK153.13083675
8GRK13.09107916
9CAMK1D3.05014711
10MAP3K133.03804596
11NME12.73265828
12EPHA32.67068818
13LMTK22.66518730
14ERN12.44631374
15MAP3K22.41892329
16TAOK12.27905225
17CDK122.20067051
18CAMK1G2.16648639
19KSR22.15671865
20PRKG22.09397584
21STK392.02457308
22TAOK31.99624475
23PIK3CG1.98441114
24TNIK1.97304053
25CDC42BPA1.80004091
26MAP2K21.78589441
27EPHA21.76048789
28TNK21.71015091
29MET1.68989060
30GRK61.56259373
31FGFR41.54589775
32PTK61.35653521
33RIPK11.34013373
34LATS11.33679230
35STK38L1.30078458
36PRKCI1.28626635
37TESK11.26545056
38MAP3K31.25732854
39NME21.23275921
40PRKAA21.17222386
41MAP3K71.16914057
42PIK3CA1.16306683
43DAPK21.13668301
44OXSR11.10983065
45STK101.10841431
46RIPK41.09899944
47MAPKAPK51.06982933
48MAPKAPK31.06130443
49MTOR1.02391057
50MATK1.00290968
51EPHB20.98142384
52TRIB30.98039572
53MAP2K10.96225988
54MAP3K10.95988680
55SIK10.90589642
56ARAF0.87093285
57EEF2K0.86328339
58BLK0.85646619
59WNK10.84858919
60SGK4940.84323119
61SGK2230.84323119
62LRRK20.83726504
63PKN20.82847220
64MYLK0.82528129
65MAP3K100.82095800
66NTRK30.82004363
67TBK10.81338516
68BMPR1B0.78757030
69RPS6KB20.78263618
70RAF10.76512858
71MAP2K60.76426875
72FER0.75460461
73PAK30.75261317
74RPS6KA20.73730163
75STK380.71763696
76MAP3K140.71713191
77DYRK1B0.70352895
78PAK40.69767399
79ZAP700.69064662
80PTK20.68869188
81PRKD30.66491876
82SGK20.64401743
83NUAK10.63428226
84WNK40.62829809
85HIPK20.62446563
86MAP3K80.59863991
87WNK30.58999166
88PIM20.58152891
89RET0.56880286
90PAK20.55628829
91INSRR0.54265299
92DMPK0.49938543
93SMG10.46853383
94GSK3A0.46438930
95CSK0.43222525
96CAMK10.42610354
97SGK10.40802878
98STK30.39529600
99NLK0.39382650
100MAPKAPK20.38124778
101PRKD20.37972408
102AKT30.37862994
103ERBB20.36916083
104MAPK80.36444219
105SGK30.35150003
106FGFR30.34887345
107CHUK0.34836839
108TTN0.34200752
109MAPK10.33801214
110RPS6KA60.33567572
111PDGFRA0.33367949
112BTK0.32548777
113PBK0.31655510
114MELK0.31312961
115MAP4K10.30594637
116RPS6KA50.29553429
117MARK20.29406475
118CDK190.28571194
119PRKCZ0.27690588
120DDR20.27689154
121SRC0.27264119
122GSK3B0.25519795
123AKT10.25068377
124CSNK1A10.25016911
125ITK0.23278630
126BMX0.22987740
127RPS6KL10.22906961
128RPS6KC10.22906961
129FYN0.22883318
130PAK10.22343621
131ICK0.22164874
132TYK20.21818659
133TEC0.20531346
134PDPK10.20479151
135IRAK10.20436723
136IKBKB0.20286307
137CDK70.20035516
138DAPK30.19401624
139EPHB10.18925722
140PRKACG0.18094771
141KIT0.18071716
142PRKAA10.18061164
143MAPK130.18040589
144KSR10.17862520
145PRKCD0.16847559
146PASK0.16783200
147PRKCA0.14561829
148MAPK110.14288993
149TRPM70.13255144

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.96799087
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.95120296
3Mineral absorption_Homo sapiens_hsa049783.83215589
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.68887188
5Sulfur metabolism_Homo sapiens_hsa009203.32048251
6Vitamin digestion and absorption_Homo sapiens_hsa049773.29766899
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.23392237
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.95996893
9Caffeine metabolism_Homo sapiens_hsa002322.82116786
10Renin-angiotensin system_Homo sapiens_hsa046142.79440411
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.65276640
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60166864
13Galactose metabolism_Homo sapiens_hsa000522.21314249
14Gastric acid secretion_Homo sapiens_hsa049712.17854908
15Fatty acid biosynthesis_Homo sapiens_hsa000612.07834472
16Sphingolipid metabolism_Homo sapiens_hsa006001.98366436
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96376357
18Arginine biosynthesis_Homo sapiens_hsa002201.87314321
19Linoleic acid metabolism_Homo sapiens_hsa005911.78554524
20Protein digestion and absorption_Homo sapiens_hsa049741.77458907
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73643206
22Bile secretion_Homo sapiens_hsa049761.69962444
23Folate biosynthesis_Homo sapiens_hsa007901.69851172
24Starch and sucrose metabolism_Homo sapiens_hsa005001.64233342
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58340013
26Histidine metabolism_Homo sapiens_hsa003401.56449160
27Arginine and proline metabolism_Homo sapiens_hsa003301.55291463
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52321779
29Propanoate metabolism_Homo sapiens_hsa006401.52075480
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49320944
31Fructose and mannose metabolism_Homo sapiens_hsa000511.46773740
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.43870431
33Glutathione metabolism_Homo sapiens_hsa004801.43721701
34Lysine degradation_Homo sapiens_hsa003101.41100195
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.39885640
36Collecting duct acid secretion_Homo sapiens_hsa049661.32522579
37Pancreatic secretion_Homo sapiens_hsa049721.31940891
38Fatty acid metabolism_Homo sapiens_hsa012121.31773267
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30692657
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.30207784
41ABC transporters_Homo sapiens_hsa020101.23580473
42Prostate cancer_Homo sapiens_hsa052151.23477990
43Ovarian steroidogenesis_Homo sapiens_hsa049131.22674416
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20277000
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16221106
46Chemical carcinogenesis_Homo sapiens_hsa052041.15568546
47Arachidonic acid metabolism_Homo sapiens_hsa005901.14589861
48Type II diabetes mellitus_Homo sapiens_hsa049301.06974844
49Glycerophospholipid metabolism_Homo sapiens_hsa005641.05949352
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03669645
51Thyroid hormone synthesis_Homo sapiens_hsa049181.02581789
52Ether lipid metabolism_Homo sapiens_hsa005651.00122988
53Glycerolipid metabolism_Homo sapiens_hsa005610.97220716
54Insulin resistance_Homo sapiens_hsa049310.93518065
55Nitrogen metabolism_Homo sapiens_hsa009100.90037168
56Glucagon signaling pathway_Homo sapiens_hsa049220.87676199
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86445936
58Sulfur relay system_Homo sapiens_hsa041220.86059982
59Tight junction_Homo sapiens_hsa045300.81248151
60Tryptophan metabolism_Homo sapiens_hsa003800.79043081
61Peroxisome_Homo sapiens_hsa041460.77806406
62AMPK signaling pathway_Homo sapiens_hsa041520.77012463
63Circadian rhythm_Homo sapiens_hsa047100.74777897
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73894092
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72291400
66Vibrio cholerae infection_Homo sapiens_hsa051100.70278428
67Tyrosine metabolism_Homo sapiens_hsa003500.69854955
68Insulin secretion_Homo sapiens_hsa049110.67018676
69Thyroid cancer_Homo sapiens_hsa052160.66417763
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65525125
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62729167
72Fatty acid degradation_Homo sapiens_hsa000710.62463616
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60688239
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59415404
75Other glycan degradation_Homo sapiens_hsa005110.57646791
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56237936
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54904809
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53178057
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.53028094
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52057863
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51783019
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51096791
83Salmonella infection_Homo sapiens_hsa051320.50572725
84Retinol metabolism_Homo sapiens_hsa008300.47925617
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46953365
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.46839085
87Phenylalanine metabolism_Homo sapiens_hsa003600.46753843
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44739921
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43945207
90Dorso-ventral axis formation_Homo sapiens_hsa043200.43206153
91mTOR signaling pathway_Homo sapiens_hsa041500.43150849
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.42256666
93Phototransduction_Homo sapiens_hsa047440.42106263
94GnRH signaling pathway_Homo sapiens_hsa049120.41773508
95VEGF signaling pathway_Homo sapiens_hsa043700.39127230
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.38965539
97Metabolic pathways_Homo sapiens_hsa011000.38298235
98Amphetamine addiction_Homo sapiens_hsa050310.37999921
99Cholinergic synapse_Homo sapiens_hsa047250.37168862
100Legionellosis_Homo sapiens_hsa051340.34643501
101Calcium signaling pathway_Homo sapiens_hsa040200.34283957
102PPAR signaling pathway_Homo sapiens_hsa033200.34001497
103Notch signaling pathway_Homo sapiens_hsa043300.33281015
104Hepatitis C_Homo sapiens_hsa051600.32980695
105beta-Alanine metabolism_Homo sapiens_hsa004100.30916349
106Platelet activation_Homo sapiens_hsa046110.27298645
107Influenza A_Homo sapiens_hsa051640.26832495
108Acute myeloid leukemia_Homo sapiens_hsa052210.25876517
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25599249
110Selenocompound metabolism_Homo sapiens_hsa004500.25532033
111Taste transduction_Homo sapiens_hsa047420.25377411
112Lysosome_Homo sapiens_hsa041420.25207079
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.24967132
114Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24767443
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24341249
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24229565
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23660163
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23261166
119cAMP signaling pathway_Homo sapiens_hsa040240.23014939
120Adherens junction_Homo sapiens_hsa045200.22969147
121Choline metabolism in cancer_Homo sapiens_hsa052310.22721487
122Pyruvate metabolism_Homo sapiens_hsa006200.22553073
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21998009
124Pentose phosphate pathway_Homo sapiens_hsa000300.21922697
125Bladder cancer_Homo sapiens_hsa052190.20523762
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19501532
127Cocaine addiction_Homo sapiens_hsa050300.19501235
128Estrogen signaling pathway_Homo sapiens_hsa049150.19419387
129N-Glycan biosynthesis_Homo sapiens_hsa005100.18946481
130Salivary secretion_Homo sapiens_hsa049700.17409334
131Toxoplasmosis_Homo sapiens_hsa051450.16039037
132Pertussis_Homo sapiens_hsa051330.15693102
133Renin secretion_Homo sapiens_hsa049240.15421637
134Long-term depression_Homo sapiens_hsa047300.14421532
135Insulin signaling pathway_Homo sapiens_hsa049100.12973606
136Drug metabolism - other enzymes_Homo sapiens_hsa009830.12025401
137Butanoate metabolism_Homo sapiens_hsa006500.11472982
138Prolactin signaling pathway_Homo sapiens_hsa049170.10010444
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09616589
140Serotonergic synapse_Homo sapiens_hsa047260.09225144
141Apoptosis_Homo sapiens_hsa042100.08517133

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