ANO7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.77748561
2cellular response to type I interferon (GO:0071357)4.28255320
3type I interferon signaling pathway (GO:0060337)4.28255320
4response to type I interferon (GO:0034340)4.22293037
5regulation of T-helper 1 cell differentiation (GO:0045625)4.08016562
6fusion of sperm to egg plasma membrane (GO:0007342)4.02404046
7regulation of T-helper 2 cell differentiation (GO:0045628)3.79255569
8cellular response to virus (GO:0098586)3.69384071
9positive regulation of Cdc42 GTPase activity (GO:0043089)3.55543197
10positive regulation of type 2 immune response (GO:0002830)3.54915187
11lipoxygenase pathway (GO:0019372)3.54333642
12germinal center formation (GO:0002467)3.32185246
13regulation of interferon-alpha production (GO:0032647)3.31571819
14regulation of vitamin D biosynthetic process (GO:0060556)3.27862719
15regulation of RIG-I signaling pathway (GO:0039535)3.26851122
16regulation of type 2 immune response (GO:0002828)3.17478301
17regulation of platelet aggregation (GO:0090330)3.15511488
18adenosine receptor signaling pathway (GO:0001973)3.12096105
19response to peptidoglycan (GO:0032494)3.08798228
20regulation of chronic inflammatory response (GO:0002676)3.08062825
21cellular response to interferon-alpha (GO:0035457)3.06116397
22regulation of platelet activation (GO:0010543)2.99046675
23regulation of interferon-beta biosynthetic process (GO:0045357)2.96185923
24lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93642118
25positive regulation of interferon-alpha production (GO:0032727)2.92938098
26granulocyte activation (GO:0036230)2.92936430
27macrophage activation involved in immune response (GO:0002281)2.92662087
28negative regulation of viral genome replication (GO:0045071)2.88224999
29negative regulation of homotypic cell-cell adhesion (GO:0034111)2.88061328
30negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.83118467
31negative regulation of erythrocyte differentiation (GO:0045647)2.83106162
32modulation by symbiont of host cellular process (GO:0044068)2.80959624
33regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78769583
34negative regulation of cytokine production involved in immune response (GO:0002719)2.78104078
35peptide catabolic process (GO:0043171)2.76840873
36immunoglobulin mediated immune response (GO:0016064)2.76651673
37regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.75491501
38plasma membrane fusion (GO:0045026)2.73730627
39negative regulation of platelet activation (GO:0010544)2.70895421
40NIK/NF-kappaB signaling (GO:0038061)2.67518384
41activation of MAPKKK activity (GO:0000185)2.66413569
42interferon-gamma-mediated signaling pathway (GO:0060333)2.65870975
43neutrophil activation (GO:0042119)2.65755720
44hemoglobin metabolic process (GO:0020027)2.65246867
45positive regulation of cAMP-mediated signaling (GO:0043950)2.64196650
46positive regulation of chemokine biosynthetic process (GO:0045080)2.62831768
47regulation of vitamin metabolic process (GO:0030656)2.62661637
48cellular response to exogenous dsRNA (GO:0071360)2.61325087
49myeloid cell activation involved in immune response (GO:0002275)2.58473978
50negative regulation of interleukin-12 production (GO:0032695)2.58424593
51regulation of integrin-mediated signaling pathway (GO:2001044)2.56858755
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56784312
53modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56784312
54positive regulation by organism of defense response of other organism involved in symbiotic interact2.56784312
55modulation by symbiont of host immune response (GO:0052553)2.56784312
56positive regulation by symbiont of host defense response (GO:0052509)2.56784312
57modulation by symbiont of host defense response (GO:0052031)2.56784312
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.56558288
59positive regulation of cellular amide metabolic process (GO:0034250)2.55732780
60decidualization (GO:0046697)2.54074013
61regulation of membrane protein ectodomain proteolysis (GO:0051043)2.53167768
62cellular response to thyroid hormone stimulus (GO:0097067)2.52192232
63regulation of integrin activation (GO:0033623)2.50504755
64regulation of chemokine biosynthetic process (GO:0045073)2.49729686
65oxygen transport (GO:0015671)2.48618870
66detection of bacterium (GO:0016045)2.48496409
67myeloid dendritic cell differentiation (GO:0043011)2.47898994
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47234966
69negative regulation of viral entry into host cell (GO:0046597)2.47031442
70response to interferon-alpha (GO:0035455)2.46363870
71detection of other organism (GO:0098543)2.44489705
72JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44376645
73fibril organization (GO:0097435)2.42000113
74positive regulation of receptor recycling (GO:0001921)2.41051944
75hyaluronan catabolic process (GO:0030214)2.39513842
76regulation of early endosome to late endosome transport (GO:2000641)2.39483741
77regulation of podosome assembly (GO:0071801)2.37352461
78modulation by virus of host process (GO:0019054)2.36081306
79positive regulation of natural killer cell differentiation (GO:0032825)2.36031333
80regulation of T-helper cell differentiation (GO:0045622)2.35975462
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.34918497
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34692796
83gas transport (GO:0015669)2.34383394
84positive regulation of T-helper cell differentiation (GO:0045624)2.30548784
85regulation of immunoglobulin secretion (GO:0051023)2.29945405
86regulation of mast cell degranulation (GO:0043304)2.29686562
87antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29462920
88negative regulation of type 2 immune response (GO:0002829)2.28196324
89positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.27793011
90protoporphyrinogen IX metabolic process (GO:0046501)2.27772122
91leukocyte degranulation (GO:0043299)2.27297267
92regulation of interferon-gamma biosynthetic process (GO:0045072)2.26450497
93positive regulation of tumor necrosis factor production (GO:0032760)2.24634418
94glycosphingolipid catabolic process (GO:0046479)2.22866576
95positive regulation of interleukin-6 production (GO:0032755)2.22028858
96negative regulation of nitric oxide biosynthetic process (GO:0045019)2.21509661
97cellular response to arsenic-containing substance (GO:0071243)2.20781611
98virion attachment to host cell (GO:0019062)2.20336210
99adhesion of symbiont to host cell (GO:0044650)2.20336210
100negative regulation of viral process (GO:0048525)2.20107472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.53893186
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86483626
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.81525081
4GATA1_19941826_ChIP-Seq_K562_Human2.73392606
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.49673226
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47492483
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39845774
8NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23951622
9LXR_22292898_ChIP-Seq_THP-1_Human2.20080847
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19560623
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16290127
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.14926749
13SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.09605703
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06495764
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98970538
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97677777
17GATA1_22025678_ChIP-Seq_K562_Human1.96575368
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.96263190
19GATA1_19941827_ChIP-Seq_MEL_Mouse1.94353023
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88936861
21SPI1_23127762_ChIP-Seq_K562_Human1.88141811
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85926420
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84402941
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.83835037
25SCL_19346495_ChIP-Seq_HPC-7_Human1.83306373
26GATA2_19941826_ChIP-Seq_K562_Human1.77955049
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.77602888
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75572373
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73580275
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72688647
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.68761953
32VDR_24763502_ChIP-Seq_THP-1_Human1.64765328
33RACK7_27058665_Chip-Seq_MCF-7_Human1.63131312
34GATA1_22383799_ChIP-Seq_G1ME_Mouse1.61956058
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.61101442
36TCF7_22412390_ChIP-Seq_EML_Mouse1.61099132
37MAF_26560356_Chip-Seq_TH1_Human1.60976488
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59703109
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57833328
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.56661988
41VDR_21846776_ChIP-Seq_THP-1_Human1.56059297
42BCOR_27268052_Chip-Seq_Bcells_Human1.55906098
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52755984
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52565305
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52186381
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51748693
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50464121
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50020298
49NCOR1_26117541_ChIP-Seq_K562_Human1.49240643
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48364620
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48132886
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.46636487
53BCL6_27268052_Chip-Seq_Bcells_Human1.46619367
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.43526364
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42773535
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42699539
57KDM2B_26808549_Chip-Seq_DND41_Human1.39858507
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39679265
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37987331
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34139446
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33982929
62P68_20966046_ChIP-Seq_HELA_Human1.33245382
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32650233
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29999760
65UTX_26944678_Chip-Seq_JUKART_Human1.28071440
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.26888860
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.23362501
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22757887
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20861000
70MAF_26560356_Chip-Seq_TH2_Human1.20186701
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20127255
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17200915
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17168781
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16944458
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.14737021
76ATF3_27146783_Chip-Seq_COLON_Human1.13985921
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12867417
78SMC4_20622854_ChIP-Seq_HELA_Human1.11203867
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10895926
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10489911
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09170667
82KDM2B_26808549_Chip-Seq_K562_Human1.09054533
83TP63_22573176_ChIP-Seq_HFKS_Human1.08018897
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07767171
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07505267
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06506645
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06262796
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05707801
89STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05589844
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04797739
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04370519
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03991613
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02992325
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01665341
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01017708
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00972445
97SA1_27219007_Chip-Seq_Bcells_Human1.00717899
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00683570
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99459550
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.99163822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.50658114
2MP0005464_abnormal_platelet_physiology3.61651060
3MP0003724_increased_susceptibility_to3.38329390
4MP0005058_abnormal_lysosome_morphology3.01835951
5MP0003436_decreased_susceptibility_to2.69277580
6MP0001835_abnormal_antigen_presentation2.61565630
7MP0004510_myositis2.61336585
8MP0008004_abnormal_stomach_pH2.54146690
9MP0005410_abnormal_fertilization2.53064597
10MP0005451_abnormal_body_composition2.43145839
11MP0009785_altered_susceptibility_to2.39256920
12MP0006082_CNS_inflammation2.39172992
13MP0002148_abnormal_hypersensitivity_rea2.36423607
14MP0004947_skin_inflammation2.28378619
15MP0003300_gastrointestinal_ulcer2.16496549
16MP0003656_abnormal_erythrocyte_physiolo2.14896963
17MP0003453_abnormal_keratinocyte_physiol2.06419098
18MP0005000_abnormal_immune_tolerance1.97934139
19MP0005025_abnormal_response_to1.96483465
20MP0005083_abnormal_biliary_tract1.95067206
21MP0001545_abnormal_hematopoietic_system1.90301190
22MP0005397_hematopoietic_system_phenotyp1.90301190
23MP0009840_abnormal_foam_cell1.87616199
24MP0000343_altered_response_to1.85014246
25MP0005387_immune_system_phenotype1.84676892
26MP0001790_abnormal_immune_system1.84676892
27MP0001533_abnormal_skeleton_physiology1.79084689
28MP0005310_abnormal_salivary_gland1.73813495
29MP0010155_abnormal_intestine_physiology1.72382819
30MP0003566_abnormal_cell_adhesion1.69788159
31MP0002419_abnormal_innate_immunity1.69642527
32MP0003191_abnormal_cellular_cholesterol1.63033445
33MP0009333_abnormal_splenocyte_physiolog1.62853793
34MP0002132_abnormal_respiratory_system1.62682343
35MP0009764_decreased_sensitivity_to1.57880504
36MP0003828_pulmonary_edema1.55611303
37MP0002723_abnormal_immune_serum1.54062795
38MP0005671_abnormal_response_to1.47750831
39MP0002452_abnormal_antigen_presenting1.47387189
40MP0003879_abnormal_hair_cell1.46329977
41MP0000858_altered_metastatic_potential1.45990240
42MP0009278_abnormal_bone_marrow1.45764876
43MP0000685_abnormal_immune_system1.42315606
44MP0001800_abnormal_humoral_immune1.41857551
45MP0001853_heart_inflammation1.40608938
46MP0002332_abnormal_exercise_endurance1.37769096
47MP0003075_altered_response_to1.37402277
48MP0001845_abnormal_inflammatory_respons1.36747587
49MP0003705_abnormal_hypodermis_morpholog1.36276969
50MP0002139_abnormal_hepatobiliary_system1.29557014
51MP0003091_abnormal_cell_migration1.29527582
52MP0002796_impaired_skin_barrier1.29455051
53MP0003172_abnormal_lysosome_physiology1.25107746
54MP0005666_abnormal_adipose_tissue1.22872245
55MP0001819_abnormal_immune_cell1.18312360
56MP0008469_abnormal_protein_level1.17389772
57MP0002420_abnormal_adaptive_immunity1.17035251
58MP0005167_abnormal_blood-brain_barrier1.13688948
59MP0002405_respiratory_system_inflammati1.12156365
60MP0005377_hearing/vestibular/ear_phenot1.12089827
61MP0003878_abnormal_ear_physiology1.12089827
62MP0005023_abnormal_wound_healing1.09691690
63MP0005501_abnormal_skin_physiology1.09441922
64MP0008874_decreased_physiological_sensi1.08239975
65MP0005164_abnormal_response_to1.06930007
66MP0002998_abnormal_bone_remodeling1.05255352
67MP0009763_increased_sensitivity_to1.03550562
68MP0003448_altered_tumor_morphology1.02519143
69MP0002398_abnormal_bone_marrow1.00905749
70MP0008260_abnormal_autophagy0.98190617
71MP0002254_reproductive_system_inflammat0.97571626
72MP0005165_increased_susceptibility_to0.97353751
73MP0002138_abnormal_hepatobiliary_system0.95498396
74MP0001542_abnormal_bone_strength0.95055627
75MP0001851_eye_inflammation0.90100191
76MP0000249_abnormal_blood_vessel0.89711199
77MP0003806_abnormal_nucleotide_metabolis0.89599207
78MP0005275_abnormal_skin_tensile0.88860754
79MP0000716_abnormal_immune_system0.88208928
80MP0000465_gastrointestinal_hemorrhage0.88166610
81MP0002429_abnormal_blood_cell0.87520236
82MP0004883_abnormal_blood_vessel0.85919442
83MP0005166_decreased_susceptibility_to0.85660174
84MP0001849_ear_inflammation0.84635372
85MP0001663_abnormal_digestive_system0.82034201
86MP0005390_skeleton_phenotype0.81997100
87MP0000678_abnormal_parathyroid_gland0.81151328
88MP0001216_abnormal_epidermal_layer0.80674493
89MP0002877_abnormal_melanocyte_morpholog0.80459754
90MP0002722_abnormal_immune_system0.80382307
91MP0009765_abnormal_xenobiotic_induced0.77936081
92MP0003045_fibrosis0.77624184
93MP0000689_abnormal_spleen_morphology0.74071079
94MP0010234_abnormal_vibrissa_follicle0.72435350
95MP0009643_abnormal_urine_homeostasis0.71032605
96MP0006054_spinal_hemorrhage0.70345353
97MP0005535_abnormal_body_temperature0.69890534
98MP0009931_abnormal_skin_appearance0.69425585
99MP0005365_abnormal_bile_salt0.66000992
100MP0003763_abnormal_thymus_physiology0.65885653

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.82878863
2Purpura (HP:0000979)4.73909467
3Petechiae (HP:0000967)4.56955338
4Menorrhagia (HP:0000132)4.11604492
5Nasal polyposis (HP:0100582)3.97631638
6Abnormality of macrophages (HP:0004311)3.69639407
7Abnormality of the nasal mucosa (HP:0000433)3.63075027
8Increased mean platelet volume (HP:0011877)3.59968417
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.59923774
10Epistaxis (HP:0000421)3.59838115
11Abnormal platelet volume (HP:0011876)3.58035063
12Systemic lupus erythematosus (HP:0002725)3.41878444
13Abnormality of glycolipid metabolism (HP:0010969)3.41384534
14Abnormality of liposaccharide metabolism (HP:0010968)3.41384534
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.41384534
16Hyperlipoproteinemia (HP:0010980)3.20290974
17Male infertility (HP:0003251)3.18443013
18Dysostosis multiplex (HP:0000943)3.11890463
19Poikilocytosis (HP:0004447)3.04037505
20Gingival bleeding (HP:0000225)2.96349125
21Eczematoid dermatitis (HP:0000976)2.93068236
22Testicular neoplasm (HP:0010788)2.81774244
23Polycythemia (HP:0001901)2.77530240
24Orchitis (HP:0100796)2.70387123
25Increased IgE level (HP:0003212)2.70057784
26Abnormal platelet function (HP:0011869)2.69479676
27Impaired platelet aggregation (HP:0003540)2.69479676
28Vacuolated lymphocytes (HP:0001922)2.65410355
29Increased serum ferritin (HP:0003281)2.59926963
30Gonadal dysgenesis (HP:0000133)2.57323119
31Retrobulbar optic neuritis (HP:0100654)2.54828701
32Optic neuritis (HP:0100653)2.54828701
33Paralysis (HP:0003470)2.51920729
34Cholecystitis (HP:0001082)2.51847061
35Abnormal gallbladder physiology (HP:0012438)2.51847061
36Loss of speech (HP:0002371)2.50242111
37Stomatitis (HP:0010280)2.50027870
38Interstitial pulmonary disease (HP:0006530)2.48504364
39Recurrent bacterial skin infections (HP:0005406)2.42202329
40Myositis (HP:0100614)2.41273226
41Asymmetric septal hypertrophy (HP:0001670)2.40099464
42Increased IgM level (HP:0003496)2.40071879
43Hepatosplenomegaly (HP:0001433)2.35012824
44Abnormality of iron homeostasis (HP:0011031)2.27785350
45Reticulocytosis (HP:0001923)2.26609168
46Thin bony cortex (HP:0002753)2.25605914
47Recurrent abscess formation (HP:0002722)2.25158507
48Mesangial abnormality (HP:0001966)2.23828605
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23128328
50Increased cerebral lipofuscin (HP:0011813)2.21260094
51Hypertriglyceridemia (HP:0002155)2.19921945
52Mediastinal lymphadenopathy (HP:0100721)2.18334498
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18184230
54Abnormality of polysaccharide metabolism (HP:0011012)2.18184230
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18184230
56Myocardial infarction (HP:0001658)2.16345077
57Hypergammaglobulinemia (HP:0010702)2.16193651
58Elevated erythrocyte sedimentation rate (HP:0003565)2.15583122
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11513997
60Hypochromic microcytic anemia (HP:0004840)2.09133231
61Spontaneous hematomas (HP:0007420)2.09063197
62Hemorrhage of the eye (HP:0011885)2.07898986
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.07745758
64Absent/shortened dynein arms (HP:0200106)2.07745758
65Axonal loss (HP:0003447)2.05196642
66Urinary glycosaminoglycan excretion (HP:0003541)2.04134715
67Mucopolysacchariduria (HP:0008155)2.04134715
68Cholelithiasis (HP:0001081)2.03695922
69Acanthocytosis (HP:0001927)2.03510311
70Gingivitis (HP:0000230)2.02158172
71Basal ganglia calcification (HP:0002135)2.01554324
72Keratoconjunctivitis sicca (HP:0001097)2.01358364
73Abnormality of lateral ventricle (HP:0030047)1.99030488
74Joint swelling (HP:0001386)1.98547908
75Arterial thrombosis (HP:0004420)1.97277362
76Generalized aminoaciduria (HP:0002909)1.96509272
77Abnormality of transition element cation homeostasis (HP:0011030)1.95909137
78Autoimmune thrombocytopenia (HP:0001973)1.95362010
79Glomerulopathy (HP:0100820)1.94876061
80Glomerulonephritis (HP:0000099)1.94749096
81Vertebral compression fractures (HP:0002953)1.94076304
82Hyperparathyroidism (HP:0000843)1.94008723
83Abnormality of the common coagulation pathway (HP:0010990)1.92776174
84Bruising susceptibility (HP:0000978)1.91283195
85Erythema (HP:0010783)1.90805601
86Nuclear cataract (HP:0100018)1.88723260
87Chronic obstructive pulmonary disease (HP:0006510)1.87969574
88Obstructive lung disease (HP:0006536)1.87969574
89Nephritis (HP:0000123)1.87864382
90Distal lower limb muscle weakness (HP:0009053)1.86294494
91Rickets (HP:0002748)1.85333088
92Gangrene (HP:0100758)1.85283993
93Abnormality of the Achilles tendon (HP:0005109)1.81825316
94Ileus (HP:0002595)1.80273222
95Abnormal ciliary motility (HP:0012262)1.80026838
96Microcytic anemia (HP:0001935)1.78697759
97Abnormality of complement system (HP:0005339)1.77171011
98Abnormality of the costochondral junction (HP:0000919)1.76947156
99Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75714601
100Recurrent gram-negative bacterial infections (HP:0005420)1.75561210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.24101025
2RIPK42.97171783
3TAOK22.90542059
4RIPK12.84458281
5PRPF4B2.65218409
6MAP3K32.60059545
7ERN12.40616251
8BMX2.22876049
9TRIB32.15520057
10TBK12.07387452
11PIM22.05306537
12TESK12.00135142
13DDR21.86477091
14MAP3K111.82457874
15TAOK11.80493331
16SIK11.77906053
17NME21.67771639
18EPHB11.66517744
19IKBKB1.64156206
20MAP2K31.63703354
21BLK1.58818385
22IKBKE1.57035739
23JAK31.54518010
24ZAP701.52329006
25MAP3K11.47628469
26TYK21.44886365
27MAP3K141.40168980
28MYLK1.37162634
29GRK71.34731417
30TESK21.33895534
31MAPKAPK31.33097889
32BMPR21.30579154
33IRAK41.27607706
34MST41.27335545
35FGR1.24651910
36PTK2B1.24034939
37PLK41.23487013
38GRK61.22856493
39MST1R1.20685540
40ICK1.19026482
41EIF2AK11.18403936
42BTK1.16771168
43MATK1.14927009
44ARAF1.14845600
45SIK31.13321297
46EPHA21.12885291
47CDK120.99106012
48PDPK10.98773091
49MAP4K10.98304010
50CSK0.94699948
51PIK3CG0.93962893
52FGFR40.93760276
53BRD40.91560026
54MOS0.88343487
55JAK10.87293416
56TNK20.86960002
57CDC42BPA0.85572366
58KSR20.84791410
59MARK30.84125697
60PAK10.82953707
61SYK0.82845104
62CHUK0.81370780
63CSF1R0.80875743
64ILK0.80502486
65JAK20.80195822
66MAP3K50.80166373
67STK380.77956260
68HIPK20.75480071
69PDK10.75300519
70PKN20.74523392
71DYRK1B0.72682066
72IRAK10.70834127
73HCK0.69085886
74GRK50.68163776
75MAPK150.63873320
76ABL20.63144028
77LYN0.60973798
78RPS6KA20.56761900
79EPHB20.55147602
80DAPK30.54725420
81PAK40.54475591
82TGFBR20.52585937
83IRAK20.50223007
84MARK20.48763944
85EPHA30.48639372
86MAPK110.48454216
87MAP3K80.47987892
88MAP3K20.47510552
89BRAF0.47209185
90CLK10.43574949
91SIK20.43482428
92PIM10.43231649
93STK100.42967433
94SMG10.41933185
95MAP3K60.41239270
96MAPKAPK20.40602512
97PRKG20.38640445
98LATS20.37588885
99DYRK30.37167740
100PKN10.36711395

Predicted pathways (KEGG)

RankGene SetZ-score
1Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62609176
2Malaria_Homo sapiens_hsa051442.52549887
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.29041079
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21297232
5Other glycan degradation_Homo sapiens_hsa005112.16878729
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.07646536
7Osteoclast differentiation_Homo sapiens_hsa043802.01025623
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.87193626
9Influenza A_Homo sapiens_hsa051641.84066681
10Staphylococcus aureus infection_Homo sapiens_hsa051501.81996824
11Allograft rejection_Homo sapiens_hsa053301.70397128
12Leishmaniasis_Homo sapiens_hsa051401.67026229
13TNF signaling pathway_Homo sapiens_hsa046681.64364065
14Lysosome_Homo sapiens_hsa041421.64242231
15African trypanosomiasis_Homo sapiens_hsa051431.57414304
16Hepatitis C_Homo sapiens_hsa051601.54622467
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48150743
18Pertussis_Homo sapiens_hsa051331.48128698
19Platelet activation_Homo sapiens_hsa046111.47790602
20Autoimmune thyroid disease_Homo sapiens_hsa053201.47590189
21Hematopoietic cell lineage_Homo sapiens_hsa046401.47043243
22Tuberculosis_Homo sapiens_hsa051521.46682064
23Measles_Homo sapiens_hsa051621.44929880
24Toxoplasmosis_Homo sapiens_hsa051451.37767480
25Acute myeloid leukemia_Homo sapiens_hsa052211.35772158
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.27825962
27Herpes simplex infection_Homo sapiens_hsa051681.27684092
28Asthma_Homo sapiens_hsa053101.26992702
29Graft-versus-host disease_Homo sapiens_hsa053321.26067384
30Rheumatoid arthritis_Homo sapiens_hsa053231.23806901
31Legionellosis_Homo sapiens_hsa051341.22805587
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22077248
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21156323
34Chemokine signaling pathway_Homo sapiens_hsa040621.19079621
35B cell receptor signaling pathway_Homo sapiens_hsa046621.17337308
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16528478
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.16068533
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15811544
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.14994221
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11424881
41Apoptosis_Homo sapiens_hsa042101.09794696
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09624773
43Hepatitis B_Homo sapiens_hsa051611.09085358
44Salmonella infection_Homo sapiens_hsa051321.08552423
45Prion diseases_Homo sapiens_hsa050201.06907132
46Shigellosis_Homo sapiens_hsa051311.05752437
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05651234
48Complement and coagulation cascades_Homo sapiens_hsa046101.01771734
49Bladder cancer_Homo sapiens_hsa052191.01262020
50VEGF signaling pathway_Homo sapiens_hsa043700.98953925
51Galactose metabolism_Homo sapiens_hsa000520.98809615
52Endocytosis_Homo sapiens_hsa041440.98529791
53Phagosome_Homo sapiens_hsa041450.93692452
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93628670
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92307546
56Viral myocarditis_Homo sapiens_hsa054160.90017446
57Pancreatic cancer_Homo sapiens_hsa052120.88745064
58Amoebiasis_Homo sapiens_hsa051460.88205029
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86965806
60Sphingolipid metabolism_Homo sapiens_hsa006000.86031743
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83086825
62Fatty acid biosynthesis_Homo sapiens_hsa000610.82406676
63Chronic myeloid leukemia_Homo sapiens_hsa052200.78605681
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75493628
65Glutathione metabolism_Homo sapiens_hsa004800.75210925
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74718506
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74217155
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73906832
69Sulfur metabolism_Homo sapiens_hsa009200.73138260
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72765995
71Antigen processing and presentation_Homo sapiens_hsa046120.72530344
72Prolactin signaling pathway_Homo sapiens_hsa049170.70611897
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.69976064
74Systemic lupus erythematosus_Homo sapiens_hsa053220.69366619
75Fructose and mannose metabolism_Homo sapiens_hsa000510.67389774
76Pentose phosphate pathway_Homo sapiens_hsa000300.66722383
77Notch signaling pathway_Homo sapiens_hsa043300.66450131
78Viral carcinogenesis_Homo sapiens_hsa052030.66112142
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65846292
80ECM-receptor interaction_Homo sapiens_hsa045120.63849816
81Phenylalanine metabolism_Homo sapiens_hsa003600.63724017
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.61476873
83T cell receptor signaling pathway_Homo sapiens_hsa046600.61174394
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60699439
85Type I diabetes mellitus_Homo sapiens_hsa049400.60301217
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59063015
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57108716
88PPAR signaling pathway_Homo sapiens_hsa033200.52240864
89Collecting duct acid secretion_Homo sapiens_hsa049660.51897251
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51677480
91Non-small cell lung cancer_Homo sapiens_hsa052230.51094679
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.49215455
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48351439
94Insulin resistance_Homo sapiens_hsa049310.45467511
95ABC transporters_Homo sapiens_hsa020100.43956998
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43888063
97Tyrosine metabolism_Homo sapiens_hsa003500.43277550
98Renal cell carcinoma_Homo sapiens_hsa052110.42357276
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.41429245
100Endometrial cancer_Homo sapiens_hsa052130.41315520

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