

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 5.29204910 |
| 2 | locomotory exploration behavior (GO:0035641) | 5.24560206 |
| 3 | layer formation in cerebral cortex (GO:0021819) | 4.90654329 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.77006879 |
| 5 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.71208207 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.54797413 |
| 7 | regulation of synapse structural plasticity (GO:0051823) | 4.33756653 |
| 8 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.28532651 |
| 9 | establishment of mitochondrion localization (GO:0051654) | 4.21013605 |
| 10 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.11660388 |
| 11 | cell-cell junction maintenance (GO:0045217) | 4.11544944 |
| 12 | vocalization behavior (GO:0071625) | 4.05526510 |
| 13 | mitochondrion transport along microtubule (GO:0047497) | 4.03666136 |
| 14 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 4.03666136 |
| 15 | dendritic spine morphogenesis (GO:0060997) | 4.02878898 |
| 16 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.97580577 |
| 17 | presynaptic membrane organization (GO:0097090) | 3.88011052 |
| 18 | presynaptic membrane assembly (GO:0097105) | 3.82029771 |
| 19 | semaphorin-plexin signaling pathway (GO:0071526) | 3.78848226 |
| 20 | sodium ion export (GO:0071436) | 3.74663430 |
| 21 | axon ensheathment in central nervous system (GO:0032291) | 3.72515458 |
| 22 | central nervous system myelination (GO:0022010) | 3.72515458 |
| 23 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.71911278 |
| 24 | glutamate secretion (GO:0014047) | 3.71230418 |
| 25 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.69159533 |
| 26 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.67742087 |
| 27 | exploration behavior (GO:0035640) | 3.64640227 |
| 28 | activation of protein kinase A activity (GO:0034199) | 3.61566605 |
| 29 | cell migration in hindbrain (GO:0021535) | 3.60538800 |
| 30 | dendrite morphogenesis (GO:0048813) | 3.58534163 |
| 31 | nucleobase catabolic process (GO:0046113) | 3.58114146 |
| 32 | establishment of nucleus localization (GO:0040023) | 3.57939261 |
| 33 | synaptic vesicle exocytosis (GO:0016079) | 3.49624132 |
| 34 | cerebellar Purkinje cell layer development (GO:0021680) | 3.45557434 |
| 35 | plasma membrane repair (GO:0001778) | 3.44537878 |
| 36 | neuromuscular process controlling balance (GO:0050885) | 3.41735756 |
| 37 | cell communication by electrical coupling (GO:0010644) | 3.39098709 |
| 38 | cell junction maintenance (GO:0034331) | 3.36818725 |
| 39 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.34965892 |
| 40 | positive regulation of synapse maturation (GO:0090129) | 3.34252885 |
| 41 | protein localization to synapse (GO:0035418) | 3.27420989 |
| 42 | camera-type eye morphogenesis (GO:0048593) | 3.25892670 |
| 43 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.25593522 |
| 44 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.25526242 |
| 45 | neurotransmitter secretion (GO:0007269) | 3.25189385 |
| 46 | proline transport (GO:0015824) | 3.24097404 |
| 47 | regulation of synapse maturation (GO:0090128) | 3.20577634 |
| 48 | regulation of ARF protein signal transduction (GO:0032012) | 3.19831948 |
| 49 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.18642890 |
| 50 | cellular potassium ion homeostasis (GO:0030007) | 3.17115139 |
| 51 | regulation of synaptic vesicle transport (GO:1902803) | 3.15252701 |
| 52 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.12701955 |
| 53 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.10159686 |
| 54 | axonal fasciculation (GO:0007413) | 3.09728219 |
| 55 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.07193520 |
| 56 | neuron projection extension (GO:1990138) | 3.06790498 |
| 57 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.03873850 |
| 58 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.03172149 |
| 59 | prepulse inhibition (GO:0060134) | 3.01784766 |
| 60 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.99952586 |
| 61 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.95365884 |
| 62 | regulation of ARF GTPase activity (GO:0032312) | 2.94680759 |
| 63 | negative regulation of axonogenesis (GO:0050771) | 2.92723309 |
| 64 | neuron recognition (GO:0008038) | 2.90965652 |
| 65 | gamma-aminobutyric acid transport (GO:0015812) | 2.89253940 |
| 66 | glycine transport (GO:0015816) | 2.87680278 |
| 67 | clathrin coat assembly (GO:0048268) | 2.86891069 |
| 68 | spinal cord development (GO:0021510) | 2.84998000 |
| 69 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.83098880 |
| 70 | neuron cell-cell adhesion (GO:0007158) | 2.81290621 |
| 71 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.80389749 |
| 72 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.78462894 |
| 73 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.78383629 |
| 74 | neuronal action potential propagation (GO:0019227) | 2.77801866 |
| 75 | regulation of axonogenesis (GO:0050770) | 2.77116872 |
| 76 | dendritic spine organization (GO:0097061) | 2.76466214 |
| 77 | positive regulation of synapse assembly (GO:0051965) | 2.76325433 |
| 78 | collecting duct development (GO:0072044) | 2.74882871 |
| 79 | auditory behavior (GO:0031223) | 2.74045141 |
| 80 | neuronal ion channel clustering (GO:0045161) | 2.73921629 |
| 81 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.73398755 |
| 82 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.73325825 |
| 83 | mechanosensory behavior (GO:0007638) | 2.72835247 |
| 84 | synapse assembly (GO:0007416) | 2.69992300 |
| 85 | cellular response to monoamine stimulus (GO:0071868) | 2.69822825 |
| 86 | cellular response to catecholamine stimulus (GO:0071870) | 2.69822825 |
| 87 | vesicle transport along microtubule (GO:0047496) | 2.69013408 |
| 88 | neural tube development (GO:0021915) | 2.66936194 |
| 89 | positive regulation of axon extension (GO:0045773) | 2.64753668 |
| 90 | innervation (GO:0060384) | 2.64445827 |
| 91 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.64278608 |
| 92 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.64250838 |
| 93 | positive regulation of fibroblast migration (GO:0010763) | 2.64234499 |
| 94 | long-term memory (GO:0007616) | 2.63932841 |
| 95 | dopamine receptor signaling pathway (GO:0007212) | 2.62563730 |
| 96 | transmission of nerve impulse (GO:0019226) | 2.62389541 |
| 97 | mannose metabolic process (GO:0006013) | 2.61997886 |
| 98 | cell differentiation in hindbrain (GO:0021533) | 2.61980274 |
| 99 | negative regulation of catenin import into nucleus (GO:0035414) | 2.61345853 |
| 100 | nerve growth factor signaling pathway (GO:0038180) | 2.59981139 |
| 101 | negative regulation of cell size (GO:0045792) | 2.59788339 |
| 102 | synaptic transmission, glutamatergic (GO:0035249) | 2.59206147 |
| 103 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.58688466 |
| 104 | axon extension (GO:0048675) | 2.58286604 |
| 105 | positive regulation of membrane potential (GO:0045838) | 2.58249999 |
| 106 | membrane depolarization during action potential (GO:0086010) | 2.56618038 |
| 107 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.56028947 |
| 108 | axon extension involved in axon guidance (GO:0048846) | 2.56028947 |
| 109 | respiratory system process (GO:0003016) | 2.55722872 |
| 110 | organelle transport along microtubule (GO:0072384) | 2.55628738 |
| 111 | response to parathyroid hormone (GO:0071107) | 2.55451834 |
| 112 | stress fiber assembly (GO:0043149) | 2.55277112 |
| 113 | glutamate receptor signaling pathway (GO:0007215) | 2.55250863 |
| 114 | convergent extension (GO:0060026) | 2.54973853 |
| 115 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.54493791 |
| 116 | regulation of respiratory system process (GO:0044065) | 2.54319459 |
| 117 | potassium ion import (GO:0010107) | 2.53183361 |
| 118 | regulation of axon guidance (GO:1902667) | 2.53141814 |
| 119 | cell communication involved in cardiac conduction (GO:0086065) | 2.52693902 |
| 120 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.52679681 |
| 121 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.51868210 |
| 122 | regulation of synaptic plasticity (GO:0048167) | 2.51182595 |
| 123 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.50617748 |
| 124 | regulation of vesicle fusion (GO:0031338) | 2.50164853 |
| 125 | regulation of postsynaptic membrane potential (GO:0060078) | 2.49254181 |
| 126 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316 | 2.49158973 |
| 127 | positive regulation of dendritic spine development (GO:0060999) | 2.48323658 |
| 128 | axon cargo transport (GO:0008088) | 2.47505811 |
| 129 | potassium ion homeostasis (GO:0055075) | 2.46524294 |
| 130 | postsynaptic membrane organization (GO:0001941) | 2.45647017 |
| 131 | glial cell proliferation (GO:0014009) | 2.45135068 |
| 132 | regulation of dendritic spine development (GO:0060998) | 2.45002102 |
| 133 | alanine transport (GO:0032328) | 2.44250536 |
| 134 | response to auditory stimulus (GO:0010996) | 2.43665301 |
| 135 | suckling behavior (GO:0001967) | 2.43111334 |
| 136 | positive regulation of dendrite development (GO:1900006) | 2.40486271 |
| 137 | peptidyl-lysine dimethylation (GO:0018027) | 2.40292317 |
| 138 | negative regulation of microtubule polymerization (GO:0031115) | 2.39572882 |
| 139 | neuromuscular process (GO:0050905) | 2.38952807 |
| 140 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.38359182 |
| 141 | cerebellar granule cell differentiation (GO:0021707) | 2.37937279 |
| 142 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.37670408 |
| 143 | protein localization to endosome (GO:0036010) | 2.36990925 |
| 144 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.36190943 |
| 145 | synaptic vesicle endocytosis (GO:0048488) | 2.35593553 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.90169885 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.44903971 |
| 3 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 3.14818386 |
| 4 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.66537736 |
| 5 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.57998597 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.42171355 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.42171355 |
| 8 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.36095646 |
| 9 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.35691495 |
| 10 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.30747643 |
| 11 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.26370588 |
| 12 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.24166127 |
| 13 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.22524427 |
| 14 | KDM2B_26808549_Chip-Seq_K562_Human | 2.22064215 |
| 15 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.19992481 |
| 16 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 2.17493939 |
| 17 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.12386061 |
| 18 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.06027397 |
| 19 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.01250117 |
| 20 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.99558919 |
| 21 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.98167278 |
| 22 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.96761009 |
| 23 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.96378434 |
| 24 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.93494701 |
| 25 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.90653119 |
| 26 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.88087035 |
| 27 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.87586422 |
| 28 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.86832791 |
| 29 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.85624757 |
| 30 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.83517536 |
| 31 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.83272236 |
| 32 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.82854280 |
| 33 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.81955975 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.76025017 |
| 35 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.75221701 |
| 36 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.72917220 |
| 37 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.72827021 |
| 38 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.71756166 |
| 39 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.68360281 |
| 40 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.68249453 |
| 41 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.62450579 |
| 42 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.62326865 |
| 43 | P68_20966046_ChIP-Seq_HELA_Human | 1.62275761 |
| 44 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.62086866 |
| 45 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.61982209 |
| 46 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.52425285 |
| 47 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.47691985 |
| 48 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.47668723 |
| 49 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.45425876 |
| 50 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.44281072 |
| 51 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.44032317 |
| 52 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.43888930 |
| 53 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.42056695 |
| 54 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.41631044 |
| 55 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.39585964 |
| 56 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.38907203 |
| 57 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.33669474 |
| 58 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.33650437 |
| 59 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.33184311 |
| 60 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.33139283 |
| 61 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.33060062 |
| 62 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.30097859 |
| 63 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.29557671 |
| 64 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.29537645 |
| 65 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.23081201 |
| 66 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.23036097 |
| 67 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.21863020 |
| 68 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.21372158 |
| 69 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.21069308 |
| 70 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.20097121 |
| 71 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.20095895 |
| 72 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.18550504 |
| 73 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.15864279 |
| 74 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.15164738 |
| 75 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 1.14324176 |
| 76 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.14067782 |
| 77 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.12766457 |
| 78 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.12047710 |
| 79 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.11330876 |
| 80 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.10479332 |
| 81 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.09685459 |
| 82 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.09247689 |
| 83 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08896707 |
| 84 | AR_19668381_ChIP-Seq_PC3_Human | 1.08584793 |
| 85 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.06483310 |
| 86 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.06370974 |
| 87 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.06126540 |
| 88 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.06093522 |
| 89 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.05705377 |
| 90 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.02957422 |
| 91 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.02334918 |
| 92 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.01516971 |
| 93 | * SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.01351045 |
| 94 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.01134337 |
| 95 | MYC_22102868_ChIP-Seq_BL_Human | 1.00252770 |
| 96 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.99452149 |
| 97 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.98019684 |
| 98 | TP63_22573176_ChIP-Seq_HFKS_Human | 0.97611781 |
| 99 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.97223523 |
| 100 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.96725851 |
| 101 | * RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.96644038 |
| 102 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.96247217 |
| 103 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.95319299 |
| 104 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.93660330 |
| 105 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.93383552 |
| 106 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.92860147 |
| 107 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.92608265 |
| 108 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.91792636 |
| 109 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.90592346 |
| 110 | SA1_27219007_Chip-Seq_Bcells_Human | 0.90555379 |
| 111 | * NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.89919702 |
| 112 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.89572601 |
| 113 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.89315622 |
| 114 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.89021187 |
| 115 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.88223330 |
| 116 | TP53_16413492_ChIP-PET_HCT116_Human | 0.87001417 |
| 117 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.86241431 |
| 118 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.86230046 |
| 119 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.85983537 |
| 120 | * TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.85917664 |
| 121 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.85535486 |
| 122 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.85521828 |
| 123 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.85482245 |
| 124 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.84250042 |
| 125 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.83797749 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.15449773 |
| 2 | MP0003635_abnormal_synaptic_transmissio | 3.31854748 |
| 3 | MP0004270_analgesia | 2.97252097 |
| 4 | MP0009780_abnormal_chondrocyte_physiolo | 2.78767821 |
| 5 | MP0004858_abnormal_nervous_system | 2.70777944 |
| 6 | MP0003283_abnormal_digestive_organ | 2.56144215 |
| 7 | MP0002063_abnormal_learning/memory/cond | 2.53814025 |
| 8 | MP0003123_paternal_imprinting | 2.45011174 |
| 9 | MP0000751_myopathy | 2.39676864 |
| 10 | MP0005423_abnormal_somatic_nervous | 2.32838066 |
| 11 | MP0003705_abnormal_hypodermis_morpholog | 2.28718754 |
| 12 | MP0009745_abnormal_behavioral_response | 2.26632663 |
| 13 | MP0003880_abnormal_central_pattern | 2.19397983 |
| 14 | MP0002909_abnormal_adrenal_gland | 2.16594159 |
| 15 | MP0002064_seizures | 2.10573936 |
| 16 | MP0005623_abnormal_meninges_morphology | 2.07104122 |
| 17 | MP0008961_abnormal_basal_metabolism | 2.05368950 |
| 18 | MP0002822_catalepsy | 2.04028241 |
| 19 | MP0002249_abnormal_larynx_morphology | 1.99053823 |
| 20 | MP0000569_abnormal_digit_pigmentation | 1.94535042 |
| 21 | MP0001502_abnormal_circadian_rhythm | 1.92061121 |
| 22 | MP0003329_amyloid_beta_deposits | 1.89506770 |
| 23 | MP0009046_muscle_twitch | 1.88267586 |
| 24 | MP0008569_lethality_at_weaning | 1.87877742 |
| 25 | MP0004811_abnormal_neuron_physiology | 1.85402773 |
| 26 | MP0000778_abnormal_nervous_system | 1.83865979 |
| 27 | MP0001188_hyperpigmentation | 1.78142741 |
| 28 | MP0000566_synostosis | 1.76953875 |
| 29 | MP0002734_abnormal_mechanical_nocicepti | 1.76419055 |
| 30 | MP0002572_abnormal_emotion/affect_behav | 1.74228499 |
| 31 | MP0001968_abnormal_touch/_nociception | 1.73431870 |
| 32 | MP0005409_darkened_coat_color | 1.66114572 |
| 33 | MP0006276_abnormal_autonomic_nervous | 1.65536544 |
| 34 | MP0003121_genomic_imprinting | 1.62936252 |
| 35 | MP0004130_abnormal_muscle_cell | 1.61793488 |
| 36 | MP0000955_abnormal_spinal_cord | 1.60301595 |
| 37 | MP0004233_abnormal_muscle_weight | 1.58422840 |
| 38 | MP0005076_abnormal_cell_differentiation | 1.58281090 |
| 39 | MP0002184_abnormal_innervation | 1.55588715 |
| 40 | MP0001486_abnormal_startle_reflex | 1.50537426 |
| 41 | MP0006292_abnormal_olfactory_placode | 1.50069050 |
| 42 | MP0002234_abnormal_pharynx_morphology | 1.47455547 |
| 43 | MP0002733_abnormal_thermal_nociception | 1.45647011 |
| 44 | MP0005499_abnormal_olfactory_system | 1.44443371 |
| 45 | MP0005394_taste/olfaction_phenotype | 1.44443371 |
| 46 | MP0001299_abnormal_eye_distance/ | 1.44215718 |
| 47 | MP0010234_abnormal_vibrissa_follicle | 1.44106530 |
| 48 | MP0009379_abnormal_foot_pigmentation | 1.43882307 |
| 49 | MP0004145_abnormal_muscle_electrophysio | 1.43138460 |
| 50 | MP0001984_abnormal_olfaction | 1.40096672 |
| 51 | MP0002272_abnormal_nervous_system | 1.38679713 |
| 52 | MP0000013_abnormal_adipose_tissue | 1.38023133 |
| 53 | MP0003878_abnormal_ear_physiology | 1.33938549 |
| 54 | MP0005377_hearing/vestibular/ear_phenot | 1.33938549 |
| 55 | MP0008438_abnormal_cutaneous_collagen | 1.32499944 |
| 56 | MP0004885_abnormal_endolymph | 1.30273700 |
| 57 | MP0001348_abnormal_lacrimal_gland | 1.29851010 |
| 58 | MP0001440_abnormal_grooming_behavior | 1.26332818 |
| 59 | MP0003942_abnormal_urinary_system | 1.25361628 |
| 60 | MP0001970_abnormal_pain_threshold | 1.24871905 |
| 61 | MP0004133_heterotaxia | 1.23731950 |
| 62 | MP0000579_abnormal_nail_morphology | 1.23421496 |
| 63 | MP0002557_abnormal_social/conspecific_i | 1.22105763 |
| 64 | MP0003045_fibrosis | 1.22037589 |
| 65 | MP0000747_muscle_weakness | 1.20302949 |
| 66 | MP0002067_abnormal_sensory_capabilities | 1.19933898 |
| 67 | MP0002882_abnormal_neuron_morphology | 1.19356933 |
| 68 | MP0004510_myositis | 1.17876325 |
| 69 | MP0004087_abnormal_muscle_fiber | 1.17670622 |
| 70 | MP0002735_abnormal_chemical_nociception | 1.16209985 |
| 71 | MP0000049_abnormal_middle_ear | 1.16146978 |
| 72 | MP0002752_abnormal_somatic_nervous | 1.15183707 |
| 73 | MP0002089_abnormal_postnatal_growth/wei | 1.15114207 |
| 74 | MP0000003_abnormal_adipose_tissue | 1.14889794 |
| 75 | MP0004924_abnormal_behavior | 1.14798017 |
| 76 | MP0005386_behavior/neurological_phenoty | 1.14798017 |
| 77 | MP0001501_abnormal_sleep_pattern | 1.13030135 |
| 78 | MP0003303_peritoneal_inflammation | 1.12567632 |
| 79 | MP0003136_yellow_coat_color | 1.12475143 |
| 80 | MP0003938_abnormal_ear_development | 1.11682288 |
| 81 | MP0002066_abnormal_motor_capabilities/c | 1.11155558 |
| 82 | MP0000537_abnormal_urethra_morphology | 1.10513382 |
| 83 | MP0000733_abnormal_muscle_development | 1.09871179 |
| 84 | MP0002736_abnormal_nociception_after | 1.09378390 |
| 85 | MP0000026_abnormal_inner_ear | 1.08590934 |
| 86 | MP0002152_abnormal_brain_morphology | 1.08525168 |
| 87 | MP0002116_abnormal_craniofacial_bone | 1.07162431 |
| 88 | MP0000631_abnormal_neuroendocrine_gland | 1.07144608 |
| 89 | MP0008789_abnormal_olfactory_epithelium | 1.06137550 |
| 90 | MP0003172_abnormal_lysosome_physiology | 1.05915737 |
| 91 | MP0003633_abnormal_nervous_system | 1.05867886 |
| 92 | MP0003690_abnormal_glial_cell | 1.05603968 |
| 93 | MP0000759_abnormal_skeletal_muscle | 1.02699419 |
| 94 | MP0002837_dystrophic_cardiac_calcinosis | 0.99005443 |
| 95 | MP0003075_altered_response_to | 0.98658979 |
| 96 | MP0002653_abnormal_ependyma_morphology | 0.98582122 |
| 97 | MP0003787_abnormal_imprinting | 0.97934061 |
| 98 | MP0000678_abnormal_parathyroid_gland | 0.97030065 |
| 99 | MP0000534_abnormal_ureter_morphology | 0.95930122 |
| 100 | MP0002877_abnormal_melanocyte_morpholog | 0.95555514 |
| 101 | MP0003634_abnormal_glial_cell | 0.95490834 |
| 102 | MP0003879_abnormal_hair_cell | 0.95198562 |
| 103 | MP0001849_ear_inflammation | 0.95016714 |
| 104 | MP0010030_abnormal_orbit_morphology | 0.94676618 |
| 105 | MP0003137_abnormal_impulse_conducting | 0.94328897 |
| 106 | MP0009384_cardiac_valve_regurgitation | 0.90749449 |
| 107 | MP0004185_abnormal_adipocyte_glucose | 0.89872547 |
| 108 | MP0005375_adipose_tissue_phenotype | 0.89741016 |
| 109 | MP0004142_abnormal_muscle_tone | 0.89492783 |
| 110 | MP0003091_abnormal_cell_migration | 0.86056866 |
| 111 | MP0005275_abnormal_skin_tensile | 0.86026725 |
| 112 | MP0005187_abnormal_penis_morphology | 0.85969868 |
| 113 | MP0004084_abnormal_cardiac_muscle | 0.85897446 |
| 114 | MP0002638_abnormal_pupillary_reflex | 0.85868781 |
| 115 | MP0003300_gastrointestinal_ulcer | 0.85115971 |
| 116 | MP0001485_abnormal_pinna_reflex | 0.85031081 |
| 117 | MP0004085_abnormal_heartbeat | 0.84306680 |
| 118 | MP0001963_abnormal_hearing_physiology | 0.84121252 |
| 119 | MP0004742_abnormal_vestibular_system | 0.83499459 |
| 120 | MP0002896_abnormal_bone_mineralization | 0.83441935 |
| 121 | MP0005167_abnormal_blood-brain_barrier | 0.83344500 |
| 122 | MP0002081_perinatal_lethality | 0.82608503 |
| 123 | MP0005257_abnormal_intraocular_pressure | 0.82157569 |
| 124 | MP0001177_atelectasis | 0.81892536 |
| 125 | MP0003631_nervous_system_phenotype | 0.81081904 |
| 126 | MP0002932_abnormal_joint_morphology | 0.80154737 |
| 127 | MP0003861_abnormal_nervous_system | 0.79594001 |
| 128 | MP0000604_amyloidosis | 0.78791372 |
| 129 | MP0005670_abnormal_white_adipose | 0.78349441 |
| 130 | MP0002269_muscular_atrophy | 0.78200451 |
| 131 | MP0002106_abnormal_muscle_physiology | 0.77471316 |
| 132 | MP0000749_muscle_degeneration | 0.77036716 |
| 133 | MP0003385_abnormal_body_wall | 0.76916891 |
| 134 | MP0001943_abnormal_respiration | 0.76629403 |
| 135 | MP0002069_abnormal_eating/drinking_beha | 0.75236921 |
| 136 | MP0001958_emphysema | 0.75089546 |
| 137 | MP0000428_abnormal_craniofacial_morphol | 0.74855696 |
| 138 | MP0002697_abnormal_eye_size | 0.73326266 |
| 139 | MP0008874_decreased_physiological_sensi | 0.72087936 |
| 140 | MP0003948_abnormal_gas_homeostasis | 0.71866559 |
| 141 | MP0003119_abnormal_digestive_system | 0.71499473 |
| 142 | MP0005620_abnormal_muscle_contractility | 0.69674555 |
| 143 | MP0003122_maternal_imprinting | 0.69516825 |
| 144 | MP0005369_muscle_phenotype | 0.68214127 |
| 145 | MP0004215_abnormal_myocardial_fiber | 0.67412111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 3.96127623 |
| 2 | Hyperacusis (HP:0010780) | 3.42483515 |
| 3 | Sleep apnea (HP:0010535) | 3.32749624 |
| 4 | Visual hallucinations (HP:0002367) | 3.11847637 |
| 5 | Insomnia (HP:0100785) | 3.09121467 |
| 6 | Focal seizures (HP:0007359) | 3.03776392 |
| 7 | Shallow orbits (HP:0000586) | 3.03680175 |
| 8 | Supranuclear gaze palsy (HP:0000605) | 3.01685230 |
| 9 | Action tremor (HP:0002345) | 2.96599585 |
| 10 | Abnormality of the lower motor neuron (HP:0002366) | 2.93436427 |
| 11 | Cerebral aneurysm (HP:0004944) | 2.89848742 |
| 12 | Focal motor seizures (HP:0011153) | 2.75900040 |
| 13 | Ankle clonus (HP:0011448) | 2.73625838 |
| 14 | Elfin facies (HP:0004428) | 2.73399033 |
| 15 | Pointed chin (HP:0000307) | 2.73200882 |
| 16 | Abnormality of the aortic arch (HP:0012303) | 2.72628536 |
| 17 | Difficulty running (HP:0009046) | 2.68936265 |
| 18 | Lower limb amyotrophy (HP:0007210) | 2.61525662 |
| 19 | Partial duplication of thumb phalanx (HP:0009944) | 2.60435111 |
| 20 | Hyperthyroidism (HP:0000836) | 2.56000895 |
| 21 | Insidious onset (HP:0003587) | 2.54532366 |
| 22 | Termporal pattern (HP:0011008) | 2.54532366 |
| 23 | Vitreoretinal degeneration (HP:0000655) | 2.51636174 |
| 24 | Upper limb amyotrophy (HP:0009129) | 2.50921566 |
| 25 | Distal upper limb amyotrophy (HP:0007149) | 2.50921566 |
| 26 | Bowel diverticulosis (HP:0005222) | 2.45853660 |
| 27 | Overriding aorta (HP:0002623) | 2.42735481 |
| 28 | Renovascular hypertension (HP:0100817) | 2.41720605 |
| 29 | Macroorchidism (HP:0000053) | 2.41004489 |
| 30 | Depression (HP:0000716) | 2.40473072 |
| 31 | Increased variability in muscle fiber diameter (HP:0003557) | 2.40021767 |
| 32 | Papilledema (HP:0001085) | 2.36790960 |
| 33 | Urinary urgency (HP:0000012) | 2.35434214 |
| 34 | Bladder diverticulum (HP:0000015) | 2.34102642 |
| 35 | Poor eye contact (HP:0000817) | 2.32455539 |
| 36 | Impaired social interactions (HP:0000735) | 2.32202427 |
| 37 | Abnormal social behavior (HP:0012433) | 2.32202427 |
| 38 | Broad face (HP:0000283) | 2.29985842 |
| 39 | Hypercortisolism (HP:0001578) | 2.28872131 |
| 40 | Megalencephaly (HP:0001355) | 2.28454843 |
| 41 | Dysmetric saccades (HP:0000641) | 2.27859139 |
| 42 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.27679726 |
| 43 | Mitral regurgitation (HP:0001653) | 2.25343021 |
| 44 | Bundle branch block (HP:0011710) | 2.25275840 |
| 45 | Achilles tendon contracture (HP:0001771) | 2.25236091 |
| 46 | Enlarged penis (HP:0000040) | 2.24995073 |
| 47 | Broad metatarsal (HP:0001783) | 2.22420372 |
| 48 | Hemiplegia (HP:0002301) | 2.22090636 |
| 49 | Thin bony cortex (HP:0002753) | 2.21891826 |
| 50 | Partial duplication of the phalanx of hand (HP:0009999) | 2.20688516 |
| 51 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.19088541 |
| 52 | Genetic anticipation (HP:0003743) | 2.17435614 |
| 53 | Deep palmar crease (HP:0006191) | 2.17121500 |
| 54 | Abnormal eating behavior (HP:0100738) | 2.17091237 |
| 55 | Renal duplication (HP:0000075) | 2.13151329 |
| 56 | Abnormality of binocular vision (HP:0011514) | 2.13017914 |
| 57 | Diplopia (HP:0000651) | 2.13017914 |
| 58 | Ventricular fibrillation (HP:0001663) | 2.12816599 |
| 59 | Spinal canal stenosis (HP:0003416) | 2.12726192 |
| 60 | Anomalous pulmonary venous return (HP:0010772) | 2.11421711 |
| 61 | Cerebral inclusion bodies (HP:0100314) | 2.11410009 |
| 62 | Rib fusion (HP:0000902) | 2.11253403 |
| 63 | Torticollis (HP:0000473) | 2.10318609 |
| 64 | Protrusio acetabuli (HP:0003179) | 2.10289540 |
| 65 | Mutism (HP:0002300) | 2.10031990 |
| 66 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.07344237 |
| 67 | Aplasia of the phalanges of the hand (HP:0009802) | 2.07344237 |
| 68 | Aplasia involving bones of the extremities (HP:0009825) | 2.07344237 |
| 69 | Turricephaly (HP:0000262) | 2.07337962 |
| 70 | Flat cornea (HP:0007720) | 2.06122263 |
| 71 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.02874560 |
| 72 | Ankyloglossia (HP:0010296) | 2.01231500 |
| 73 | Shawl scrotum (HP:0000049) | 2.00619090 |
| 74 | Limb dystonia (HP:0002451) | 2.00103835 |
| 75 | Hypoventilation (HP:0002791) | 1.99614461 |
| 76 | Difficulty climbing stairs (HP:0003551) | 1.98363034 |
| 77 | Polyphagia (HP:0002591) | 1.97347087 |
| 78 | Abnormality of the Achilles tendon (HP:0005109) | 1.96808810 |
| 79 | Type 1 muscle fiber predominance (HP:0003803) | 1.96415504 |
| 80 | Abnormality of the 4th metacarpal (HP:0010012) | 1.95929554 |
| 81 | Hand muscle atrophy (HP:0009130) | 1.95832283 |
| 82 | Truncus arteriosus (HP:0001660) | 1.94921690 |
| 83 | Obstructive sleep apnea (HP:0002870) | 1.94420575 |
| 84 | Rapidly progressive (HP:0003678) | 1.92865141 |
| 85 | Annular pancreas (HP:0001734) | 1.92589807 |
| 86 | Progressive cerebellar ataxia (HP:0002073) | 1.91116469 |
| 87 | Neoplasm of the heart (HP:0100544) | 1.90137468 |
| 88 | Postural instability (HP:0002172) | 1.89662440 |
| 89 | Exercise-induced myalgia (HP:0003738) | 1.89597881 |
| 90 | Precocious puberty (HP:0000826) | 1.88791635 |
| 91 | Long palpebral fissure (HP:0000637) | 1.88381312 |
| 92 | Dilatation of the ascending aorta (HP:0005111) | 1.88322237 |
| 93 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.87971926 |
| 94 | Hypoplasia of the brainstem (HP:0002365) | 1.87971926 |
| 95 | Apathy (HP:0000741) | 1.87580096 |
| 96 | Trigonocephaly (HP:0000243) | 1.87078217 |
| 97 | Stereotypic behavior (HP:0000733) | 1.85343893 |
| 98 | Buphthalmos (HP:0000557) | 1.84590808 |
| 99 | Peripheral hypomyelination (HP:0007182) | 1.84303959 |
| 100 | Distal lower limb amyotrophy (HP:0008944) | 1.83583695 |
| 101 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.83013863 |
| 102 | Amblyopia (HP:0000646) | 1.81835898 |
| 103 | Septo-optic dysplasia (HP:0100842) | 1.81650593 |
| 104 | Genu recurvatum (HP:0002816) | 1.81364815 |
| 105 | Abnormality of oral frenula (HP:0000190) | 1.81305043 |
| 106 | Bronchomalacia (HP:0002780) | 1.81208276 |
| 107 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.80692520 |
| 108 | Ankle contracture (HP:0006466) | 1.80522120 |
| 109 | Resting tremor (HP:0002322) | 1.80072743 |
| 110 | Epileptic encephalopathy (HP:0200134) | 1.79952564 |
| 111 | Scapular winging (HP:0003691) | 1.79659198 |
| 112 | Truncal ataxia (HP:0002078) | 1.79593513 |
| 113 | Generalized hypotonia (HP:0001290) | 1.79225640 |
| 114 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.78909099 |
| 115 | Amyotrophic lateral sclerosis (HP:0007354) | 1.78738419 |
| 116 | Failure to thrive in infancy (HP:0001531) | 1.78609693 |
| 117 | Akinesia (HP:0002304) | 1.78600195 |
| 118 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.78145829 |
| 119 | Dysdiadochokinesis (HP:0002075) | 1.77802017 |
| 120 | Lymphangioma (HP:0100764) | 1.76909152 |
| 121 | Broad phalanges of the hand (HP:0009768) | 1.76603298 |
| 122 | Mitral valve prolapse (HP:0001634) | 1.76582972 |
| 123 | Deviation of the hallux (HP:0010051) | 1.76425781 |
| 124 | Hallux valgus (HP:0001822) | 1.75557864 |
| 125 | Aqueductal stenosis (HP:0002410) | 1.74931886 |
| 126 | Hyporeflexia of lower limbs (HP:0002600) | 1.73610727 |
| 127 | Hammertoe (HP:0001765) | 1.73606114 |
| 128 | Premature rupture of membranes (HP:0001788) | 1.73344183 |
| 129 | Striae distensae (HP:0001065) | 1.73039225 |
| 130 | Increased connective tissue (HP:0009025) | 1.72399907 |
| 131 | Sudden death (HP:0001699) | 1.71905179 |
| 132 | Thin ribs (HP:0000883) | 1.71853436 |
| 133 | Spastic gait (HP:0002064) | 1.71524654 |
| 134 | Drooling (HP:0002307) | 1.71318055 |
| 135 | Frequent falls (HP:0002359) | 1.71092069 |
| 136 | Lower limb muscle weakness (HP:0007340) | 1.70998328 |
| 137 | Spina bifida occulta (HP:0003298) | 1.70857501 |
| 138 | Neurofibrillary tangles (HP:0002185) | 1.69696438 |
| 139 | Diminished motivation (HP:0000745) | 1.69599309 |
| 140 | Disproportionate tall stature (HP:0001519) | 1.69087377 |
| 141 | Impaired smooth pursuit (HP:0007772) | 1.69046037 |
| 142 | Long toe (HP:0010511) | 1.69044191 |
| 143 | Abnormality of the pulmonary veins (HP:0011718) | 1.68639326 |
| 144 | Short 4th metacarpal (HP:0010044) | 1.68020366 |
| 145 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.68020366 |
| 146 | Laryngomalacia (HP:0001601) | 1.67325552 |
| 147 | Broad finger (HP:0001500) | 1.66656352 |
| 148 | Tracheomalacia (HP:0002779) | 1.65392766 |
| 149 | Broad thumb (HP:0011304) | 1.65270316 |
| 150 | Stridor (HP:0010307) | 1.64425511 |
| 151 | Asymmetric growth (HP:0100555) | 1.63928801 |
| 152 | Bowel incontinence (HP:0002607) | 1.63417507 |
| 153 | Intellectual disability, severe (HP:0010864) | 1.61502923 |
| 154 | Autism (HP:0000717) | 1.59314398 |
| 155 | Excessive salivation (HP:0003781) | 1.59271377 |
| 156 | Sporadic (HP:0003745) | 1.59196550 |
| 157 | Supernumerary nipples (HP:0002558) | 1.58301873 |
| 158 | Patellar dislocation (HP:0002999) | 1.58243551 |
| 159 | Arnold-Chiari malformation (HP:0002308) | 1.57785705 |
| 160 | Hepatoblastoma (HP:0002884) | 1.57464346 |
| 161 | Metaphyseal cupping (HP:0003021) | 1.55914538 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 3.53902387 |
| 2 | MAP3K9 | 3.32575346 |
| 3 | MARK1 | 3.29974565 |
| 4 | CASK | 2.85806456 |
| 5 | NTRK3 | 2.62746680 |
| 6 | PKN2 | 2.61599311 |
| 7 | PAK6 | 2.47084252 |
| 8 | CAMKK1 | 2.30686536 |
| 9 | EPHA4 | 2.25485228 |
| 10 | PRKD3 | 2.20580531 |
| 11 | KSR2 | 2.14989979 |
| 12 | RIPK1 | 2.14800923 |
| 13 | DAPK2 | 2.07708280 |
| 14 | EEF2K | 1.93489572 |
| 15 | SIK2 | 1.89042603 |
| 16 | PDGFRA | 1.85057690 |
| 17 | MINK1 | 1.84847576 |
| 18 | TYRO3 | 1.82388440 |
| 19 | TTN | 1.78048041 |
| 20 | NTRK2 | 1.72816741 |
| 21 | MAP3K4 | 1.72121190 |
| 22 | NTRK1 | 1.68581741 |
| 23 | DYRK2 | 1.67191435 |
| 24 | KSR1 | 1.64191508 |
| 25 | TAOK1 | 1.57363171 |
| 26 | PHKG2 | 1.51306590 |
| 27 | PHKG1 | 1.51306590 |
| 28 | ICK | 1.45711590 |
| 29 | RET | 1.45102378 |
| 30 | MAP3K10 | 1.44317450 |
| 31 | CAMK1G | 1.43673113 |
| 32 | LATS2 | 1.42011870 |
| 33 | ALK | 1.41633285 |
| 34 | DDR2 | 1.41331390 |
| 35 | TNK2 | 1.40089625 |
| 36 | SCYL2 | 1.29071200 |
| 37 | MAP3K2 | 1.26429614 |
| 38 | SGK494 | 1.22670462 |
| 39 | SGK223 | 1.22670462 |
| 40 | CDK5 | 1.22411385 |
| 41 | PRKCH | 1.20341852 |
| 42 | STK38 | 1.15964613 |
| 43 | MARK2 | 1.14572697 |
| 44 | UHMK1 | 1.11986384 |
| 45 | LMTK2 | 1.09579734 |
| 46 | SIK1 | 1.08223954 |
| 47 | DMPK | 1.05105749 |
| 48 | PTK6 | 1.04668404 |
| 49 | PAK3 | 1.04415632 |
| 50 | CAMKK2 | 1.04333768 |
| 51 | STK11 | 1.02192990 |
| 52 | CAMK1D | 1.01633099 |
| 53 | BMX | 0.97151654 |
| 54 | FGFR4 | 0.96674854 |
| 55 | MAPK12 | 0.93236258 |
| 56 | PINK1 | 0.93067871 |
| 57 | MAP2K4 | 0.92995952 |
| 58 | MAP3K7 | 0.90168980 |
| 59 | MAPK15 | 0.89783714 |
| 60 | SMG1 | 0.89443478 |
| 61 | DYRK1A | 0.87436001 |
| 62 | FGFR2 | 0.87039426 |
| 63 | TNIK | 0.86824108 |
| 64 | SGK2 | 0.83129204 |
| 65 | EPHB2 | 0.81544006 |
| 66 | RPS6KC1 | 0.80339324 |
| 67 | RPS6KL1 | 0.80339324 |
| 68 | ARAF | 0.79799706 |
| 69 | CDK15 | 0.77069197 |
| 70 | PDGFRB | 0.76906504 |
| 71 | CDC42BPA | 0.76138158 |
| 72 | NEK1 | 0.75957077 |
| 73 | BRAF | 0.75713408 |
| 74 | PTK2 | 0.73841750 |
| 75 | PKN1 | 0.73530652 |
| 76 | MAP3K6 | 0.72815666 |
| 77 | CDK18 | 0.72622138 |
| 78 | RPS6KA2 | 0.72110968 |
| 79 | FES | 0.71686851 |
| 80 | FER | 0.71173794 |
| 81 | DAPK1 | 0.70176162 |
| 82 | RPS6KA6 | 0.70049907 |
| 83 | CDK14 | 0.67297735 |
| 84 | CDK11A | 0.66338847 |
| 85 | CAMK1 | 0.64313901 |
| 86 | PRKD1 | 0.62091781 |
| 87 | FGFR1 | 0.59735539 |
| 88 | ROCK1 | 0.58435078 |
| 89 | MTOR | 0.57687725 |
| 90 | PRKD2 | 0.57084761 |
| 91 | DAPK3 | 0.56892104 |
| 92 | CAMK2B | 0.56818931 |
| 93 | PRKAA1 | 0.56106073 |
| 94 | PDPK1 | 0.55075778 |
| 95 | CAMK4 | 0.54478555 |
| 96 | FYN | 0.53906367 |
| 97 | MAP3K11 | 0.53198461 |
| 98 | PAK2 | 0.52812635 |
| 99 | EPHB1 | 0.52178423 |
| 100 | PDK1 | 0.51571102 |
| 101 | MAPK13 | 0.51304917 |
| 102 | MAP2K1 | 0.49499025 |
| 103 | ILK | 0.49475784 |
| 104 | DYRK1B | 0.49002274 |
| 105 | LIMK1 | 0.48713238 |
| 106 | PRKCG | 0.48693343 |
| 107 | PRKCZ | 0.48389239 |
| 108 | SGK3 | 0.47736098 |
| 109 | ROCK2 | 0.46801386 |
| 110 | CSNK1G2 | 0.46699553 |
| 111 | RPS6KA3 | 0.46688066 |
| 112 | SGK1 | 0.45201943 |
| 113 | ERBB2 | 0.44631315 |
| 114 | MAP2K7 | 0.44012423 |
| 115 | MAP3K1 | 0.43701821 |
| 116 | HIPK2 | 0.41769713 |
| 117 | PRPF4B | 0.41055131 |
| 118 | WNK1 | 0.40004456 |
| 119 | RAF1 | 0.39857021 |
| 120 | PIK3CA | 0.39438216 |
| 121 | MAPK10 | 0.38874354 |
| 122 | MAPK8 | 0.38329389 |
| 123 | SRC | 0.38311202 |
| 124 | CDK12 | 0.37186516 |
| 125 | RPS6KA1 | 0.37112568 |
| 126 | MAP3K13 | 0.37058836 |
| 127 | RIPK4 | 0.36809388 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.07059432 |
| 2 | Circadian entrainment_Homo sapiens_hsa04713 | 1.97226662 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.93315482 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 1.92395189 |
| 5 | Long-term potentiation_Homo sapiens_hsa04720 | 1.87199150 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.74330489 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 1.69697709 |
| 8 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.68917944 |
| 9 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.64731407 |
| 10 | Nicotine addiction_Homo sapiens_hsa05033 | 1.61002646 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.60818608 |
| 12 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.60762998 |
| 13 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.60006290 |
| 14 | Glioma_Homo sapiens_hsa05214 | 1.59195984 |
| 15 | Salivary secretion_Homo sapiens_hsa04970 | 1.58150789 |
| 16 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.57510801 |
| 17 | Morphine addiction_Homo sapiens_hsa05032 | 1.57314392 |
| 18 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.52854505 |
| 19 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.50920028 |
| 20 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.50601847 |
| 21 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.49749272 |
| 22 | Insulin secretion_Homo sapiens_hsa04911 | 1.49349495 |
| 23 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.47565342 |
| 24 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.42503736 |
| 25 | Gap junction_Homo sapiens_hsa04540 | 1.40700631 |
| 26 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.39306281 |
| 27 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.35540764 |
| 28 | Cocaine addiction_Homo sapiens_hsa05030 | 1.34895330 |
| 29 | Renin secretion_Homo sapiens_hsa04924 | 1.33495921 |
| 30 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.30967833 |
| 31 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.30526481 |
| 32 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.29491308 |
| 33 | Axon guidance_Homo sapiens_hsa04360 | 1.27743865 |
| 34 | Long-term depression_Homo sapiens_hsa04730 | 1.23356496 |
| 35 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.22500929 |
| 36 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.21590626 |
| 37 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.16755988 |
| 38 | Endometrial cancer_Homo sapiens_hsa05213 | 1.16168230 |
| 39 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.15078716 |
| 40 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.13044230 |
| 41 | Melanogenesis_Homo sapiens_hsa04916 | 1.08544921 |
| 42 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.07066115 |
| 43 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.06841275 |
| 44 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.05993496 |
| 45 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.05864293 |
| 46 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.05534849 |
| 47 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.05438888 |
| 48 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.05358673 |
| 49 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.04747878 |
| 50 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.04458175 |
| 51 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.03780080 |
| 52 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.02608359 |
| 53 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.02132382 |
| 54 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.01506142 |
| 55 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.94562312 |
| 56 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.94157534 |
| 57 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.92004266 |
| 58 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.91575671 |
| 59 | Focal adhesion_Homo sapiens_hsa04510 | 0.91546539 |
| 60 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.90876463 |
| 61 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.90541241 |
| 62 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.89560748 |
| 63 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.88369430 |
| 64 | Prion diseases_Homo sapiens_hsa05020 | 0.87287513 |
| 65 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.86693169 |
| 66 | Colorectal cancer_Homo sapiens_hsa05210 | 0.86116189 |
| 67 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.84376392 |
| 68 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.82333310 |
| 69 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.81710461 |
| 70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.81442233 |
| 71 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.81090442 |
| 72 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.80775810 |
| 73 | Taste transduction_Homo sapiens_hsa04742 | 0.80454190 |
| 74 | Endocytosis_Homo sapiens_hsa04144 | 0.79869581 |
| 75 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79317915 |
| 76 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.77824747 |
| 77 | Sulfur relay system_Homo sapiens_hsa04122 | 0.77300294 |
| 78 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.75405942 |
| 79 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.74809808 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.73994056 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.73867178 |
| 82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.73600689 |
| 83 | Bladder cancer_Homo sapiens_hsa05219 | 0.73090241 |
| 84 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.72440778 |
| 85 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.71754891 |
| 86 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.70956022 |
| 87 | Platelet activation_Homo sapiens_hsa04611 | 0.70492493 |
| 88 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.69721158 |
| 89 | Lysine degradation_Homo sapiens_hsa00310 | 0.69204040 |
| 90 | Insulin resistance_Homo sapiens_hsa04931 | 0.68930309 |
| 91 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.68725162 |
| 92 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.68724274 |
| 93 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.68698320 |
| 94 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.68259970 |
| 95 | Phototransduction_Homo sapiens_hsa04744 | 0.66304937 |
| 96 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.64328928 |
| 97 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.64242942 |
| 98 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.63567740 |
| 99 | Amoebiasis_Homo sapiens_hsa05146 | 0.62897734 |
| 100 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.62399967 |
| 101 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.62271190 |
| 102 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.61877211 |
| 103 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.61657361 |
| 104 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61137301 |
| 105 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.60372636 |
| 106 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.59706416 |
| 107 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.59598501 |
| 108 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.58282308 |
| 109 | Bile secretion_Homo sapiens_hsa04976 | 0.57235947 |
| 110 | Tight junction_Homo sapiens_hsa04530 | 0.56945183 |
| 111 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.56814255 |
| 112 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.56744586 |
| 113 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.54521826 |
| 114 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.53654054 |
| 115 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.51357699 |
| 116 | Adherens junction_Homo sapiens_hsa04520 | 0.49831840 |
| 117 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.48658528 |
| 118 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.44703026 |
| 119 | Pathways in cancer_Homo sapiens_hsa05200 | 0.44568729 |

