ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.71026892
2	cytidine deamination (GO:0009972)	8.43610344
3	cytidine metabolic process (GO:0046087)	8.43610344
4	cytidine catabolic process (GO:0006216)	8.43610344
5	DNA deamination (GO:0045006)	8.36634579
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.34908366
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	6.20428109
8	actin nucleation (GO:0045010)	5.49384216
9	T cell migration (GO:0072678)	5.11502748
10	cellular response to interleukin-15 (GO:0071350)	4.74894633
11	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.64330715
12	negative regulation of calcium ion transport into cytosol (GO:0010523)	4.55265840
13	sequestering of actin monomers (GO:0042989)	4.20664514
14	positive thymic T cell selection (GO:0045059)	4.05154977
15	regulation of B cell receptor signaling pathway (GO:0050855)	4.04275415
16	cytolysis (GO:0019835)	3.99864231
17	negative regulation by host of viral transcription (GO:0043922)	3.91768620
18	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.90145972
19	negative regulation of T cell apoptotic process (GO:0070233)	3.89840280
20	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.87926442
21	regulation of regulatory T cell differentiation (GO:0045589)	3.84375248
22	response to interleukin-15 (GO:0070672)	3.82430025
23	negative T cell selection (GO:0043383)	3.77720994
24	positive T cell selection (GO:0043368)	3.77421635
25	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.77069186
26	positive regulation of gamma-delta T cell activation (GO:0046645)	3.72073062
27	response to pheromone (GO:0019236)	3.70903751
28	ribosomal small subunit assembly (GO:0000028)	3.70525468
29	positive regulation of tolerance induction (GO:0002645)	3.69928684
30	positive regulation of interleukin-8 secretion (GO:2000484)	3.63796993
31	pyrimidine nucleoside catabolic process (GO:0046135)	3.63475355
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.61870510
33	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.57980424
34	regulation of T cell tolerance induction (GO:0002664)	3.55902224
35	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.53826207
36	positive regulation of defense response to virus by host (GO:0002230)	3.53722819
37	positive regulation of monocyte chemotaxis (GO:0090026)	3.47814663
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.45628130
39	thymic T cell selection (GO:0045061)	3.43613526
40	T cell receptor signaling pathway (GO:0050852)	3.39431788
41	lymphocyte chemotaxis (GO:0048247)	3.38749630
42	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.38630934
43	regulation of interleukin-12 biosynthetic process (GO:0045075)	3.36453598
44	metallo-sulfur cluster assembly (GO:0031163)	3.35895793
45	iron-sulfur cluster assembly (GO:0016226)	3.35895793
46	negative regulation of viral genome replication (GO:0045071)	3.35383001
47	regulation of gamma-delta T cell differentiation (GO:0045586)	3.33991882
48	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.33158218
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.28700660
50	ATP synthesis coupled proton transport (GO:0015986)	3.28700660
51	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.26178471
52	regulation of natural killer cell mediated immunity (GO:0002715)	3.26178471
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.25910055
54	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.24803935
55	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.24100167
56	positive regulation of interleukin-4 production (GO:0032753)	3.22366093
57	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.20157380
58	negative thymic T cell selection (GO:0045060)	3.16851079
59	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.15812745
60	regulation of activation of Janus kinase activity (GO:0010533)	3.15013895
61	positive regulation of cell killing (GO:0031343)	3.11220548
62	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.11150721
63	positive regulation of calcium-mediated signaling (GO:0050850)	3.10310264
64	positive regulation of prostaglandin secretion (GO:0032308)	3.10144655
65	dendritic cell chemotaxis (GO:0002407)	3.07600129
66	antigen receptor-mediated signaling pathway (GO:0050851)	3.03667113
67	deoxyribose phosphate biosynthetic process (GO:0046385)	3.02922112
68	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.02922112
69	positive regulation of T cell apoptotic process (GO:0070234)	3.02794043
70	regulation of interleukin-2 biosynthetic process (GO:0045076)	3.01744668
71	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.98850893
72	cellular defense response (GO:0006968)	2.98288136
73	regulation of T cell mediated cytotoxicity (GO:0001914)	2.97480554
74	protein neddylation (GO:0045116)	2.95383042
75	pyrimidine nucleotide catabolic process (GO:0006244)	2.94617183
76	respiratory electron transport chain (GO:0022904)	2.92569427
77	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.91857683
78	electron transport chain (GO:0022900)	2.89622221
79	regulation of tolerance induction (GO:0002643)	2.89044094
80	negative regulation of stress fiber assembly (GO:0051497)	2.85960727
81	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.84232824
82	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.83721974
83	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.83721974
84	lymphocyte migration (GO:0072676)	2.83639756
85	regulation of chronic inflammatory response (GO:0002676)	2.83144978
86	T cell selection (GO:0045058)	2.82963659
87	regulation of cell killing (GO:0031341)	2.78529554
88	T cell costimulation (GO:0031295)	2.78460076
89	regulation of T cell apoptotic process (GO:0070232)	2.77338479
90	post-embryonic morphogenesis (GO:0009886)	2.76403460
91	lymphocyte costimulation (GO:0031294)	2.74858432
92	regulation of T cell chemotaxis (GO:0010819)	2.74248001
93	positive regulation of T cell chemotaxis (GO:0010820)	2.74248001
94	deoxyribonucleotide catabolic process (GO:0009264)	2.71548520
95	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.71096484
96	regulation of gamma-delta T cell activation (GO:0046643)	2.71019557
97	regulation of interleukin-8 secretion (GO:2000482)	2.70628364
98	deoxyribonucleotide biosynthetic process (GO:0009263)	2.69895995
99	DNA demethylation (GO:0080111)	2.69621918
100	regulation of defense response to virus by host (GO:0050691)	2.69047747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.17138775
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.47371512
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.58999725
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.46368312
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.42144207
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.34563412
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.01171509
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.78244825
9	MYB_26560356_Chip-Seq_TH2_Human	2.76161309
10	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.73172038
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.46485275
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.44277762
13	VDR_22108803_ChIP-Seq_LS180_Human	2.41718957
14	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.36986210
15	STAT4_19710469_ChIP-ChIP_TH1__Mouse	2.36600144
16	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.34006775
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.33856986
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33544446
19	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	2.13174666
20	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.08782697
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.08408624
22	RUNX_20019798_ChIP-Seq_JUKART_Human	2.05911950
23	VDR_23849224_ChIP-Seq_CD4+_Human	2.00208247
24	UTX_26944678_Chip-Seq_JUKART_Human	2.00010505
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.98013126
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96410806
27	CIITA_25753668_ChIP-Seq_RAJI_Human	1.92221273
28	MYB_26560356_Chip-Seq_TH1_Human	1.87138947
29	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.84964354
30	MAF_26560356_Chip-Seq_TH2_Human	1.81379354
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.78123316
32	MAF_26560356_Chip-Seq_TH1_Human	1.75012120
33	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.71423204
34	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.68655830
35	GATA3_26560356_Chip-Seq_TH2_Human	1.60697890
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.59289993
37	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.58190290
38	GATA3_27048872_Chip-Seq_THYMUS_Human	1.57863157
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.56430807
40	SPI1_23547873_ChIP-Seq_NB4_Human	1.54964481
41	BCL6_27268052_Chip-Seq_Bcells_Human	1.54350226
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.52417626
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52086040
44	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.51279379
45	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.47642258
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46173903
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44994462
48	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.38329235
49	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.38062642
50	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.34873830
51	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.32218643
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28584668
53	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27563964
54	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26654778
55	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.22070829
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21177197
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20992940
58	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19355035
59	SA1_27219007_Chip-Seq_Bcells_Human	1.16191402
60	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15762733
61	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.14818832
62	CTCF_20526341_ChIP-Seq_ESCs_Human	1.13824988
63	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12473502
64	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11834995
65	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.09021343
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07696422
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06152782
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05508474
69	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.04886128
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02872157
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.01140579
72	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.98842858
73	ERA_21632823_ChIP-Seq_H3396_Human	0.98125373
74	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.97699696
75	E2F1_20622854_ChIP-Seq_HELA_Human	0.96593900
76	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96405018
77	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.96383186
78	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.94857558
79	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.94162156
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93487643
81	EZH2_22144423_ChIP-Seq_EOC_Human	0.92462913
82	BCOR_27268052_Chip-Seq_Bcells_Human	0.92310379
83	XRN2_22483619_ChIP-Seq_HELA_Human	0.92286544
84	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.92169313
85	MYC_18940864_ChIP-ChIP_HL60_Human	0.91906204
86	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.91879832
87	GABP_19822575_ChIP-Seq_HepG2_Human	0.91734359
88	P300_27268052_Chip-Seq_Bcells_Human	0.91704256
89	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91299496
90	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91113421
91	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90979033
92	SPI1_20517297_ChIP-Seq_HL60_Human	0.90441025
93	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90312432
94	RAC3_21632823_ChIP-Seq_H3396_Human	0.89973869
95	STAT1_20625510_ChIP-Seq_HELA_Human	0.88109200
96	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87135646
97	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.85502303
98	P68_20966046_ChIP-Seq_HELA_Human	0.85477741
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.81931617
100	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.81030626

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	6.20204731
2	MP0003878_abnormal_ear_physiology	3.45307757
3	MP0005377_hearing/vestibular/ear_phenot	3.45307757
4	MP0009333_abnormal_splenocyte_physiolog	3.39448356
5	MP0009785_altered_susceptibility_to	3.35506740
6	MP0001835_abnormal_antigen_presentation	3.02523903
7	MP0003763_abnormal_thymus_physiology	2.91341971
8	MP0000685_abnormal_immune_system	2.88340707
9	MP0005000_abnormal_immune_tolerance	2.58801561
10	MP0003866_abnormal_defecation	2.54923092
11	MP0005387_immune_system_phenotype	2.53737386
12	MP0001790_abnormal_immune_system	2.53737386
13	MP0002148_abnormal_hypersensitivity_rea	2.53518120
14	MP0002723_abnormal_immune_serum	2.51945196
15	MP0001800_abnormal_humoral_immune	2.47865414
16	MP0005025_abnormal_response_to	2.45525424
17	MP0002420_abnormal_adaptive_immunity	2.37996827
18	MP0001819_abnormal_immune_cell	2.31363117
19	MP0002166_altered_tumor_susceptibility	2.10523485
20	MP0002405_respiratory_system_inflammati	2.04359646
21	MP0002398_abnormal_bone_marrow	1.98685724
22	MP0002452_abnormal_antigen_presenting	1.97960646
23	MP0000716_abnormal_immune_system	1.92464145
24	MP0002102_abnormal_ear_morphology	1.83635450
25	MP0003436_decreased_susceptibility_to	1.80038238
26	MP0005645_abnormal_hypothalamus_physiol	1.75908084
27	MP0006072_abnormal_retinal_apoptosis	1.75651140
28	MP0000703_abnormal_thymus_morphology	1.74765892
29	MP0003786_premature_aging	1.74011859
30	MP0000689_abnormal_spleen_morphology	1.69591697
31	MP0002722_abnormal_immune_system	1.69404575
32	MP0002419_abnormal_innate_immunity	1.66848814
33	MP0002138_abnormal_hepatobiliary_system	1.61942402
34	MP0005379_endocrine/exocrine_gland_phen	1.61363091
35	MP0003045_fibrosis	1.60400815
36	MP0003806_abnormal_nucleotide_metabolis	1.60296390
37	MP0002877_abnormal_melanocyte_morpholog	1.59754637
38	MP0002277_abnormal_respiratory_mucosa	1.57359624
39	MP0002876_abnormal_thyroid_physiology	1.54850904
40	MP0002429_abnormal_blood_cell	1.50823889
41	MP0003646_muscle_fatigue	1.50415632
42	MP0000372_irregular_coat_pigmentation	1.49378601
43	MP0003448_altered_tumor_morphology	1.47840401
44	MP0002006_tumorigenesis	1.47058721
45	MP0003724_increased_susceptibility_to	1.46504728
46	MP0002095_abnormal_skin_pigmentation	1.45466331
47	MP0001873_stomach_inflammation	1.42575053
48	MP0005075_abnormal_melanosome_morpholog	1.39070902
49	MP0001845_abnormal_inflammatory_respons	1.35316954
50	MP0010155_abnormal_intestine_physiology	1.33488606
51	MP0006082_CNS_inflammation	1.21515904
52	MP0001919_abnormal_reproductive_system	1.21099828
53	MP0004947_skin_inflammation	1.20233329
54	MP0002163_abnormal_gland_morphology	1.16043926
55	MP0004145_abnormal_muscle_electrophysio	1.12868966
56	MP0005084_abnormal_gallbladder_morpholo	1.10990023
57	MP0001879_abnormal_lymphatic_vessel	1.07701573
58	MP0008469_abnormal_protein_level	1.05220857
59	MP0006036_abnormal_mitochondrial_physio	1.03571632
60	MP0001968_abnormal_touch/_nociception	0.98885210
61	MP0000681_abnormal_thyroid_gland	0.97874020
62	MP0001661_extended_life_span	0.97858703
63	MP0008995_early_reproductive_senescence	0.97289605
64	MP0003879_abnormal_hair_cell	0.93618821
65	MP0005410_abnormal_fertilization	0.91128949
66	MP0002234_abnormal_pharynx_morphology	0.88743773
67	MP0002736_abnormal_nociception_after	0.87381883
68	MP0004036_abnormal_muscle_relaxation	0.87056171
69	MP0009840_abnormal_foam_cell	0.85321506
70	MP0006292_abnormal_olfactory_placode	0.84146346
71	MP0001533_abnormal_skeleton_physiology	0.84078969
72	MP0001905_abnormal_dopamine_level	0.83093250
73	MP0009763_increased_sensitivity_to	0.78880369
74	MP0005646_abnormal_pituitary_gland	0.77365568
75	MP0003195_calcinosis	0.77298039
76	MP0005083_abnormal_biliary_tract	0.76736143
77	MP0002933_joint_inflammation	0.75758095
78	MP0002019_abnormal_tumor_incidence	0.73670273
79	MP0000678_abnormal_parathyroid_gland	0.73443153
80	MP0005253_abnormal_eye_physiology	0.73113986
81	MP0006035_abnormal_mitochondrial_morpho	0.72523772
82	MP0001485_abnormal_pinna_reflex	0.64988540
83	MP0009764_decreased_sensitivity_to	0.64200116
84	MP0008007_abnormal_cellular_replicative	0.62882950
85	MP0004742_abnormal_vestibular_system	0.62667537
86	MP0004134_abnormal_chest_morphology	0.61715102
87	MP0002998_abnormal_bone_remodeling	0.61267557
88	MP0002693_abnormal_pancreas_physiology	0.59042741
89	MP0005464_abnormal_platelet_physiology	0.58325486
90	MP0003959_abnormal_lean_body	0.56266297
91	MP0005166_decreased_susceptibility_to	0.56108964
92	MP0001765_abnormal_ion_homeostasis	0.55858122
93	MP0005636_abnormal_mineral_homeostasis	0.55269905
94	MP0001243_abnormal_dermal_layer	0.55049301
95	MP0004957_abnormal_blastocyst_morpholog	0.54499315
96	MP0003252_abnormal_bile_duct	0.53998040
97	MP0005389_reproductive_system_phenotype	0.53614418
98	MP0000858_altered_metastatic_potential	0.53021341
99	MP0004381_abnormal_hair_follicle	0.52796917
100	MP0004185_abnormal_adipocyte_glucose	0.52631872

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	5.44025426
2	Abnormality of T cell number (HP:0011839)	4.99252734
3	Mitochondrial inheritance (HP:0001427)	4.11929899
4	IgG deficiency (HP:0004315)	4.05897993
5	Aplastic anemia (HP:0001915)	3.95419275
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.87034960
7	Increased intramyocellular lipid droplets (HP:0012240)	3.84801960
8	Abnormality of T cells (HP:0002843)	3.77132464
9	Agammaglobulinemia (HP:0004432)	3.58456911
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57780628
11	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.57378282
12	Acute necrotizing encephalopathy (HP:0006965)	3.55038949
13	Severe combined immunodeficiency (HP:0004430)	3.52010850
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.46946071
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.46946071
16	Congenital stationary night blindness (HP:0007642)	3.41929556
17	Persistence of primary teeth (HP:0006335)	3.35643654
18	Renal Fanconi syndrome (HP:0001994)	3.32043450
19	Recurrent bronchitis (HP:0002837)	3.25728913
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.24528806
21	Increased CSF lactate (HP:0002490)	3.23727934
22	Abnormality of the prostate (HP:0008775)	3.23463649
23	Hepatocellular necrosis (HP:0001404)	3.21263673
24	Prostate neoplasm (HP:0100787)	3.14094810
25	IgM deficiency (HP:0002850)	3.13770713
26	Abnormality of eosinophils (HP:0001879)	3.02443960
27	Increased muscle lipid content (HP:0009058)	3.00000412
28	Combined immunodeficiency (HP:0005387)	2.97269125
29	Generalized aminoaciduria (HP:0002909)	2.96100736
30	Hepatic necrosis (HP:0002605)	2.92429030
31	Progressive macrocephaly (HP:0004481)	2.85863198
32	Pancytopenia (HP:0001876)	2.84648590
33	3-Methylglutaconic aciduria (HP:0003535)	2.77923583
34	Increased hepatocellular lipid droplets (HP:0006565)	2.75950335
35	Acute encephalopathy (HP:0006846)	2.74625478
36	Renal cortical cysts (HP:0000803)	2.73022630
37	Thyroiditis (HP:0100646)	2.68214410
38	Testicular atrophy (HP:0000029)	2.61746696
39	Premature loss of primary teeth (HP:0006323)	2.58590644
40	Lymphopenia (HP:0001888)	2.55715801
41	Chronic diarrhea (HP:0002028)	2.53822061
42	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.45837124
43	Meningitis (HP:0001287)	2.39485558
44	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.38760388
45	Exercise intolerance (HP:0003546)	2.38192536
46	Hepatosplenomegaly (HP:0001433)	2.36642255
47	Leukocytosis (HP:0001974)	2.35600565
48	Stomatitis (HP:0010280)	2.33970270
49	Hypoproteinemia (HP:0003075)	2.32821111
50	Joint swelling (HP:0001386)	2.30103394
51	Autoimmune hemolytic anemia (HP:0001890)	2.29394988
52	Pustule (HP:0200039)	2.27951053
53	Increased serum lactate (HP:0002151)	2.26737700
54	Cerebral edema (HP:0002181)	2.26354980
55	Abnormality of midbrain morphology (HP:0002418)	2.24541632
56	Molar tooth sign on MRI (HP:0002419)	2.24541632
57	Amyotrophic lateral sclerosis (HP:0007354)	2.24080225
58	Recurrent otitis media (HP:0000403)	2.19229889
59	Eosinophilia (HP:0001880)	2.18318304
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17745050
61	Increased IgM level (HP:0003496)	2.16592533
62	Obstructive lung disease (HP:0006536)	2.14895147
63	Chronic obstructive pulmonary disease (HP:0006510)	2.14895147
64	Zonular cataract (HP:0010920)	2.14041220
65	Progressive external ophthalmoplegia (HP:0000590)	2.13350457
66	Abnormality of male internal genitalia (HP:0000022)	2.12081659
67	Lactic acidosis (HP:0003128)	2.10864099
68	Lipid accumulation in hepatocytes (HP:0006561)	2.09743792
69	Dysphonia (HP:0001618)	2.08722403
70	Abnormality of macrophages (HP:0004311)	2.07160768
71	Type I transferrin isoform profile (HP:0003642)	2.06760347
72	Lymphoma (HP:0002665)	2.04410442
73	Bronchitis (HP:0012387)	2.01998601
74	Myositis (HP:0100614)	2.01231359
75	Recurrent viral infections (HP:0004429)	2.00108686
76	Progressive muscle weakness (HP:0003323)	1.96947831
77	Gastrointestinal infarctions (HP:0005244)	1.96655751
78	Exertional dyspnea (HP:0002875)	1.96123085
79	Hypoplasia of the thymus (HP:0000778)	1.95199147
80	Ragged-red muscle fibers (HP:0003200)	1.93941429
81	Abnormality of T cell physiology (HP:0011840)	1.93691655
82	Encephalitis (HP:0002383)	1.93146634
83	Palpebral edema (HP:0100540)	1.92489209
84	Abnormality of the renal cortex (HP:0011035)	1.91096438
85	Increased density of long bones (HP:0006392)	1.88547970
86	Granulocytopenia (HP:0001913)	1.88468135
87	Hypergonadotropic hypogonadism (HP:0000815)	1.85395620
88	Clumsiness (HP:0002312)	1.84399480
89	Abnormality of renal resorption (HP:0011038)	1.83225228
90	Optic disc pallor (HP:0000543)	1.81082798
91	Poor speech (HP:0002465)	1.76653335
92	Hypoalbuminemia (HP:0003073)	1.75936549
93	Abnormal albumin level (HP:0012116)	1.75936549
94	Metaphyseal dysplasia (HP:0100255)	1.75785133
95	Abnormality of B cell number (HP:0010975)	1.75691920
96	Recurrent corneal erosions (HP:0000495)	1.75637422
97	Pulmonary infiltrates (HP:0002113)	1.74979701
98	Recurrent bacterial skin infections (HP:0005406)	1.74687167
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.74178112
100	Abnormality of the costochondral junction (HP:0000919)	1.72498615

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	9.10444058
2	KDR	5.44683091
3	TXK	3.77991010
4	ZAK	3.01042648
5	VRK2	2.65461897
6	BCKDK	2.46053461
7	GRK1	2.27718259
8	LIMK1	2.06335670
9	MAP4K1	2.01320932
10	GRK7	1.92829080
11	MST4	1.91501093
12	TESK1	1.82327029
13	MAPKAPK3	1.81526789
14	TLK1	1.79261959
15	ITK	1.72907177
16	WNK4	1.69759960
17	SCYL2	1.67953639
18	GRK6	1.58301441
19	VRK1	1.52413233
20	TAOK3	1.41676357
21	ADRBK2	1.38988953
22	STK16	1.33510629
23	DYRK3	1.32655551
24	FES	1.23217346
25	MAP3K14	1.21401983
26	SYK	1.14568458
27	MAP3K11	1.12355949
28	BUB1	1.10403273
29	PRKCQ	1.04454425
30	TEC	0.99722609
31	LCK	0.98343964
32	STK39	0.95498679
33	TIE1	0.95141795
34	MAP3K12	0.95055199
35	TBK1	0.94317915
36	BTK	0.92193433
37	PLK4	0.91340730
38	IKBKB	0.85711405
39	CSNK1G3	0.85297080
40	NME2	0.84359118
41	TAF1	0.82147214
42	RPS6KA4	0.78682149
43	PIK3CG	0.76157255
44	DAPK1	0.75583033
45	IKBKE	0.74290560
46	MAP2K2	0.71453880
47	TRIM28	0.69335013
48	INSRR	0.69224673
49	CSNK1A1L	0.66450717
50	MAP4K2	0.64683474
51	LYN	0.61087276
52	ZAP70	0.59725424
53	CSK	0.59086736
54	CDC7	0.58482603
55	AURKA	0.54997308
56	KIT	0.53543976
57	NUAK1	0.52801086
58	SRPK1	0.52435317
59	CHEK2	0.51556942
60	MAPKAPK5	0.51155860
61	PASK	0.50940400
62	MAPKAPK2	0.50456072
63	EIF2AK3	0.49471733
64	JAK3	0.46969017
65	EIF2AK1	0.46820368
66	RPS6KA5	0.46717835
67	CSNK1G1	0.46241365
68	OBSCN	0.46124542
69	MATK	0.45768865
70	OXSR1	0.43508438
71	CSNK1G2	0.43309483
72	STK10	0.43092391
73	CDC42BPA	0.41718228
74	AURKB	0.40899411
75	TNK2	0.40290830
76	PIK3CA	0.38932267
77	EIF2AK2	0.37475471
78	PIM1	0.36742915
79	GRK5	0.35696106
80	ADRBK1	0.34707056
81	IRAK4	0.34608425
82	MAP3K13	0.33698793
83	SMG1	0.33295359
84	CSF1R	0.33242370
85	FYN	0.33142722
86	MARK3	0.32606502
87	CSNK2A1	0.32347868
88	CSNK2A2	0.28966084
89	ATR	0.28085576
90	TAOK1	0.26146183
91	IGF1R	0.22859493
92	INSR	0.22467933
93	TRPM7	0.21891207
94	PRKCA	0.21643621
95	CDK4	0.20775423
96	RPS6KB2	0.20645171
97	TTK	0.20640766
98	PRKCD	0.20593653
99	ABL2	0.20506836
100	DYRK2	0.19208239

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.39781611
2	Proteasome_Homo sapiens_hsa03050	4.09590519
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.37031648
4	Parkinsons disease_Homo sapiens_hsa05012	2.93795261
5	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.62927505
6	Antigen processing and presentation_Homo sapiens_hsa04612	2.61370274
7	Ribosome_Homo sapiens_hsa03010	2.54963416
8	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.52732977
9	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.47493305
10	RNA polymerase_Homo sapiens_hsa03020	2.44953507
11	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.28751059
12	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.28255411
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.25630069
14	Allograft rejection_Homo sapiens_hsa05330	2.19086811
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.17271862
16	Phototransduction_Homo sapiens_hsa04744	2.03517120
17	Alzheimers disease_Homo sapiens_hsa05010	1.89291798
18	Huntingtons disease_Homo sapiens_hsa05016	1.88329832
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87330520
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.83976137
21	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.80156827
22	Protein export_Homo sapiens_hsa03060	1.77088091
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.75267480
24	Homologous recombination_Homo sapiens_hsa03440	1.70752350
25	Measles_Homo sapiens_hsa05162	1.59808071
26	DNA replication_Homo sapiens_hsa03030	1.52096251
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51289360
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46534310
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44586880
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39997097
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.37270286
32	One carbon pool by folate_Homo sapiens_hsa00670	1.34216050
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32677133
34	Base excision repair_Homo sapiens_hsa03410	1.27178708
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.13869355
36	Herpes simplex infection_Homo sapiens_hsa05168	1.12158455
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08973381
38	Purine metabolism_Homo sapiens_hsa00230	1.07067662
39	Mismatch repair_Homo sapiens_hsa03430	1.02992615
40	Olfactory transduction_Homo sapiens_hsa04740	1.01270282
41	Spliceosome_Homo sapiens_hsa03040	1.01247577
42	Shigellosis_Homo sapiens_hsa05131	0.99892964
43	Salmonella infection_Homo sapiens_hsa05132	0.99690092
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.90800877
45	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.88127784
46	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.86347011
47	Viral myocarditis_Homo sapiens_hsa05416	0.86190893
48	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78562231
49	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.76976712
50	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.76492988
51	Regulation of autophagy_Homo sapiens_hsa04140	0.74574757
52	Chemokine signaling pathway_Homo sapiens_hsa04062	0.71188590
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69931098
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.69394577
55	Asthma_Homo sapiens_hsa05310	0.68342809
56	Basal transcription factors_Homo sapiens_hsa03022	0.66752942
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.66222057
58	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.65727905
59	HTLV-I infection_Homo sapiens_hsa05166	0.65033227
60	Peroxisome_Homo sapiens_hsa04146	0.60716921
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59809250
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.59294875
63	RNA degradation_Homo sapiens_hsa03018	0.57549507
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55386139
65	Osteoclast differentiation_Homo sapiens_hsa04380	0.54549677
66	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51507975
67	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50819758
68	Sulfur metabolism_Homo sapiens_hsa00920	0.44572843
69	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42274590
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.39253395
71	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.38035096
72	Malaria_Homo sapiens_hsa05144	0.37685282
73	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.37477501
74	Leishmaniasis_Homo sapiens_hsa05140	0.34156103
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32468170
76	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30281018
77	Alcoholism_Homo sapiens_hsa05034	0.29054513
78	Metabolic pathways_Homo sapiens_hsa01100	0.29047850
79	Caffeine metabolism_Homo sapiens_hsa00232	0.28881785
80	Endocytosis_Homo sapiens_hsa04144	0.28591568
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.27805258
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.27693102
83	Viral carcinogenesis_Homo sapiens_hsa05203	0.27355459
84	Morphine addiction_Homo sapiens_hsa05032	0.25428898
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24856605
86	Glutathione metabolism_Homo sapiens_hsa00480	0.24259785
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.24213572
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.22817088
89	Lysosome_Homo sapiens_hsa04142	0.21479823
90	RNA transport_Homo sapiens_hsa03013	0.19802274
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.18738986
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.16588818
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.15886295
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.12501377
95	Apoptosis_Homo sapiens_hsa04210	0.09264003
96	Influenza A_Homo sapiens_hsa05164	0.08966070
97	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.07918000
98	Legionellosis_Homo sapiens_hsa05134	0.07628598
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.07592908
100	Tuberculosis_Homo sapiens_hsa05152	0.07146879

ANP32AP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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