

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA unwinding involved in DNA replication (GO:0006268) | 5.11250592 |
| 2 | protein localization to kinetochore (GO:0034501) | 4.62834580 |
| 3 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.42816775 |
| 4 | macromolecular complex disassembly (GO:0032984) | 4.33161223 |
| 5 | DNA replication initiation (GO:0006270) | 4.25570837 |
| 6 | DNA strand elongation (GO:0022616) | 4.20806226 |
| 7 | mitotic sister chromatid cohesion (GO:0007064) | 4.20669415 |
| 8 | protoporphyrinogen IX metabolic process (GO:0046501) | 4.13251038 |
| 9 | viral transcription (GO:0019083) | 4.10963123 |
| 10 | protein localization to chromosome, centromeric region (GO:0071459) | 4.09417610 |
| 11 | translational termination (GO:0006415) | 4.05244993 |
| 12 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.03672424 |
| 13 | mitotic nuclear envelope disassembly (GO:0007077) | 4.03101936 |
| 14 | kinetochore organization (GO:0051383) | 4.00077730 |
| 15 | nuclear pore organization (GO:0006999) | 3.99387163 |
| 16 | maturation of SSU-rRNA (GO:0030490) | 3.98986156 |
| 17 | nuclear pore complex assembly (GO:0051292) | 3.95778990 |
| 18 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.93424961 |
| 19 | regulation of translational fidelity (GO:0006450) | 3.92077884 |
| 20 | mitotic metaphase plate congression (GO:0007080) | 3.91955451 |
| 21 | ribosomal small subunit assembly (GO:0000028) | 3.91601295 |
| 22 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.89118556 |
| 23 | formation of translation preinitiation complex (GO:0001731) | 3.88986292 |
| 24 | DNA replication checkpoint (GO:0000076) | 3.86611627 |
| 25 | mitotic sister chromatid segregation (GO:0000070) | 3.83341770 |
| 26 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.77550379 |
| 27 | negative regulation of RNA splicing (GO:0033119) | 3.76497749 |
| 28 | membrane disassembly (GO:0030397) | 3.72995463 |
| 29 | nuclear envelope disassembly (GO:0051081) | 3.72995463 |
| 30 | sister chromatid segregation (GO:0000819) | 3.69730174 |
| 31 | translational initiation (GO:0006413) | 3.65031386 |
| 32 | telomere maintenance via recombination (GO:0000722) | 3.63523157 |
| 33 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.62497758 |
| 34 | mitotic recombination (GO:0006312) | 3.59895296 |
| 35 | mitotic chromosome condensation (GO:0007076) | 3.58429971 |
| 36 | translational elongation (GO:0006414) | 3.57660865 |
| 37 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.54511505 |
| 38 | metaphase plate congression (GO:0051310) | 3.54375909 |
| 39 | kinetochore assembly (GO:0051382) | 3.53105929 |
| 40 | protein targeting to membrane (GO:0006612) | 3.52331727 |
| 41 | mRNA catabolic process (GO:0006402) | 3.51476772 |
| 42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.50626768 |
| 43 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.50626768 |
| 44 | negative regulation of mRNA processing (GO:0050686) | 3.48977568 |
| 45 | ribosomal small subunit biogenesis (GO:0042274) | 3.47847893 |
| 46 | chromosome condensation (GO:0030261) | 3.39123612 |
| 47 | DNA duplex unwinding (GO:0032508) | 3.38941954 |
| 48 | IMP biosynthetic process (GO:0006188) | 3.37475408 |
| 49 | translation (GO:0006412) | 3.37375756 |
| 50 | DNA geometric change (GO:0032392) | 3.36481931 |
| 51 | regulation of spindle organization (GO:0090224) | 3.35183191 |
| 52 | telomere maintenance via telomere lengthening (GO:0010833) | 3.34637579 |
| 53 | heterochromatin organization (GO:0070828) | 3.30001719 |
| 54 | ribosomal large subunit biogenesis (GO:0042273) | 3.29074687 |
| 55 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 3.28030186 |
| 56 | DNA replication-independent nucleosome organization (GO:0034724) | 3.27987883 |
| 57 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.27987883 |
| 58 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.26326952 |
| 59 | negative regulation of mRNA metabolic process (GO:1903312) | 3.24238196 |
| 60 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.23503063 |
| 61 | ribosome assembly (GO:0042255) | 3.23080409 |
| 62 | chromatin remodeling at centromere (GO:0031055) | 3.22895920 |
| 63 | CENP-A containing nucleosome assembly (GO:0034080) | 3.22741042 |
| 64 | positive regulation of chromosome segregation (GO:0051984) | 3.21591331 |
| 65 | protein targeting to ER (GO:0045047) | 3.17356971 |
| 66 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.17115944 |
| 67 | cotranslational protein targeting to membrane (GO:0006613) | 3.16628594 |
| 68 | regulation of histone H3-K27 methylation (GO:0061085) | 3.16228609 |
| 69 | cellular protein complex disassembly (GO:0043624) | 3.15656364 |
| 70 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.14536087 |
| 71 | nucleobase biosynthetic process (GO:0046112) | 3.13816844 |
| 72 | purine nucleobase biosynthetic process (GO:0009113) | 3.13396392 |
| 73 | establishment of chromosome localization (GO:0051303) | 3.13030819 |
| 74 | establishment of integrated proviral latency (GO:0075713) | 3.11744984 |
| 75 | viral life cycle (GO:0019058) | 3.10286213 |
| 76 | RNA splicing, via transesterification reactions (GO:0000375) | 3.09391091 |
| 77 | mRNA splicing, via spliceosome (GO:0000398) | 3.09150176 |
| 78 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 3.09150176 |
| 79 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.07998723 |
| 80 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.07356888 |
| 81 | chromatin assembly or disassembly (GO:0006333) | 3.07000083 |
| 82 | 3-UTR-mediated mRNA stabilization (GO:0070935) | 3.05575816 |
| 83 | pre-miRNA processing (GO:0031054) | 3.05218695 |
| 84 | IMP metabolic process (GO:0046040) | 3.04982252 |
| 85 | pore complex assembly (GO:0046931) | 3.04523636 |
| 86 | regulation of DNA endoreduplication (GO:0032875) | 3.03583151 |
| 87 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.03122234 |
| 88 | protein complex disassembly (GO:0043241) | 3.01769250 |
| 89 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.00935432 |
| 90 | protein localization to chromosome (GO:0034502) | 3.00600368 |
| 91 | translesion synthesis (GO:0019985) | 2.98943889 |
| 92 | chromosome segregation (GO:0007059) | 2.98101898 |
| 93 | DNA packaging (GO:0006323) | 2.98056884 |
| 94 | nuclear envelope organization (GO:0006998) | 2.97902488 |
| 95 | cellular component biogenesis (GO:0044085) | 2.97220670 |
| 96 | regulation of histone H3-K4 methylation (GO:0051569) | 2.95948800 |
| 97 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.95481446 |
| 98 | regulation of RNA export from nucleus (GO:0046831) | 2.94121003 |
| 99 | meiotic chromosome segregation (GO:0045132) | 2.93503154 |
| 100 | DNA deamination (GO:0045006) | 2.93465367 |
| 101 | ATP-dependent chromatin remodeling (GO:0043044) | 2.92612154 |
| 102 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.92552331 |
| 103 | viral mRNA export from host cell nucleus (GO:0046784) | 2.92484554 |
| 104 | protein-DNA complex disassembly (GO:0032986) | 2.92310618 |
| 105 | nucleosome disassembly (GO:0006337) | 2.92310618 |
| 106 | mRNA stabilization (GO:0048255) | 2.92212797 |
| 107 | RNA stabilization (GO:0043489) | 2.92212797 |
| 108 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.91996582 |
| 109 | protein localization to endoplasmic reticulum (GO:0070972) | 2.91645593 |
| 110 | DNA ligation (GO:0006266) | 2.91495896 |
| 111 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.91029675 |
| 112 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.91029675 |
| 113 | regulation of sister chromatid cohesion (GO:0007063) | 2.91015722 |
| 114 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.90822284 |
| 115 | oxidative phosphorylation (GO:0006119) | 2.90733973 |
| 116 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.89770242 |
| 117 | DNA conformation change (GO:0071103) | 2.89296680 |
| 118 | ribosome biogenesis (GO:0042254) | 2.88636776 |
| 119 | regulation of mitotic spindle organization (GO:0060236) | 2.88557926 |
| 120 | regulation of histone H3-K9 methylation (GO:0051570) | 2.87903740 |
| 121 | termination of RNA polymerase II transcription (GO:0006369) | 2.87571511 |
| 122 | DNA topological change (GO:0006265) | 2.87419309 |
| 123 | alternative mRNA splicing, via spliceosome (GO:0000380) | 2.87303323 |
| 124 | negative regulation of histone methylation (GO:0031061) | 2.86800168 |
| 125 | erythrocyte maturation (GO:0043249) | 2.86340131 |
| 126 | histone exchange (GO:0043486) | 2.85116563 |
| 127 | RNA catabolic process (GO:0006401) | 2.84748532 |
| 128 | regulation of chromosome segregation (GO:0051983) | 2.84636521 |
| 129 | rRNA processing (GO:0006364) | 2.84484850 |
| 130 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.84163736 |
| 131 | rRNA metabolic process (GO:0016072) | 2.82572161 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 9.58476508 |
| 2 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 4.98253415 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.01224985 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.87927952 |
| 5 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.74232294 |
| 6 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.41449284 |
| 7 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.96725315 |
| 8 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.83119271 |
| 9 | * MYC_22102868_ChIP-Seq_BL_Human | 2.62118030 |
| 10 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.52262921 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.38286378 |
| 12 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.32789850 |
| 13 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.26808413 |
| 14 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.22949227 |
| 15 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.22404757 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.10443413 |
| 17 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.07935384 |
| 18 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.97776746 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.96479685 |
| 20 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.84163801 |
| 21 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.82706461 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.80566157 |
| 23 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.79677705 |
| 24 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.77005577 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.76311692 |
| 26 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.75682172 |
| 27 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.74064683 |
| 28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.73022426 |
| 29 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.72530313 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.71642469 |
| 31 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.69337541 |
| 32 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.68746668 |
| 33 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.68116981 |
| 34 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.67389081 |
| 35 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.65144167 |
| 36 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.64045009 |
| 37 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.61822855 |
| 38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.57889394 |
| 39 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.55256428 |
| 40 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.54966596 |
| 41 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.54431293 |
| 42 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.50039661 |
| 43 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.48252737 |
| 44 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.46543564 |
| 45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.44943047 |
| 46 | * NCOR1_26117541_ChIP-Seq_K562_Human | 1.44149810 |
| 47 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.44146658 |
| 48 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.43286429 |
| 49 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.34312543 |
| 50 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.33307589 |
| 51 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.32156409 |
| 52 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.30661378 |
| 53 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.30112004 |
| 54 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.29347325 |
| 55 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27880109 |
| 56 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.25719956 |
| 57 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25122122 |
| 58 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.23428742 |
| 59 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.22981209 |
| 60 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.21283079 |
| 61 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.19020414 |
| 62 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.18240649 |
| 63 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.15738774 |
| 64 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.13415804 |
| 65 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.11398876 |
| 66 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.10836817 |
| 67 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.10704321 |
| 68 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.09969206 |
| 69 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.08000614 |
| 70 | UTX_26944678_Chip-Seq_JUKART_Human | 1.07228731 |
| 71 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.06879389 |
| 72 | MAF_26560356_Chip-Seq_TH1_Human | 1.06069242 |
| 73 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.03632254 |
| 74 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.03516640 |
| 75 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.02726546 |
| 76 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.02473140 |
| 77 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.01964833 |
| 78 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.01895494 |
| 79 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.01890652 |
| 80 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.01366417 |
| 81 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.00478039 |
| 82 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.98809595 |
| 83 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 0.98692515 |
| 84 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.98037876 |
| 85 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.97961842 |
| 86 | MYB_26560356_Chip-Seq_TH1_Human | 0.95724016 |
| 87 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.94974865 |
| 88 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.94877612 |
| 89 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.93821269 |
| 90 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93809639 |
| 91 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.93600213 |
| 92 | GATA1_22025678_ChIP-Seq_K562_Human | 0.93216933 |
| 93 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.93177999 |
| 94 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.92527429 |
| 95 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.91748954 |
| 96 | MYB_26560356_Chip-Seq_TH2_Human | 0.91647912 |
| 97 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.91374816 |
| 98 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91333485 |
| 99 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.91235900 |
| 100 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.90851219 |
| 101 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.90772475 |
| 102 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.90729429 |
| 103 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.90423325 |
| 104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.89525879 |
| 105 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.88393900 |
| 106 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.87249995 |
| 107 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.86473489 |
| 108 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 0.86294202 |
| 109 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.85657768 |
| 110 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.85612832 |
| 111 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.84677488 |
| 112 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.83672840 |
| 113 | * MAF_26560356_Chip-Seq_TH2_Human | 0.83059150 |
| 114 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.81622420 |
| 115 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.80632358 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.60740793 |
| 2 | MP0010094_abnormal_chromosome_stability | 3.99535574 |
| 3 | MP0003111_abnormal_nucleus_morphology | 3.95283085 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.88846508 |
| 5 | MP0009379_abnormal_foot_pigmentation | 3.61093767 |
| 6 | MP0008057_abnormal_DNA_replication | 3.58996862 |
| 7 | MP0003077_abnormal_cell_cycle | 3.52404501 |
| 8 | MP0002396_abnormal_hematopoietic_system | 2.83899847 |
| 9 | MP0010352_gastrointestinal_tract_polyps | 2.60849730 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.33986488 |
| 11 | MP0008058_abnormal_DNA_repair | 2.32429888 |
| 12 | MP0001730_embryonic_growth_arrest | 2.30019507 |
| 13 | MP0004147_increased_porphyrin_level | 2.26248772 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.19078017 |
| 15 | MP0008932_abnormal_embryonic_tissue | 2.16456800 |
| 16 | MP0005451_abnormal_body_composition | 2.01705375 |
| 17 | MP0003123_paternal_imprinting | 1.99430819 |
| 18 | MP0003806_abnormal_nucleotide_metabolis | 1.97491896 |
| 19 | MP0004808_abnormal_hematopoietic_stem | 1.91867504 |
| 20 | MP0005076_abnormal_cell_differentiation | 1.90491336 |
| 21 | MP0010307_abnormal_tumor_latency | 1.85108248 |
| 22 | MP0005380_embryogenesis_phenotype | 1.77670185 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.77670185 |
| 24 | MP0000678_abnormal_parathyroid_gland | 1.76380081 |
| 25 | MP0000490_abnormal_crypts_of | 1.76284914 |
| 26 | MP0001697_abnormal_embryo_size | 1.76220442 |
| 27 | MP0008995_early_reproductive_senescence | 1.70765191 |
| 28 | MP0001545_abnormal_hematopoietic_system | 1.69649598 |
| 29 | MP0005397_hematopoietic_system_phenotyp | 1.69649598 |
| 30 | MP0003984_embryonic_growth_retardation | 1.68976683 |
| 31 | MP0002088_abnormal_embryonic_growth/wei | 1.65427909 |
| 32 | MP0004197_abnormal_fetal_growth/weight/ | 1.61231547 |
| 33 | MP0002084_abnormal_developmental_patter | 1.61045561 |
| 34 | MP0002085_abnormal_embryonic_tissue | 1.58706809 |
| 35 | MP0002086_abnormal_extraembryonic_tissu | 1.56803563 |
| 36 | MP0002080_prenatal_lethality | 1.56233739 |
| 37 | MP0003567_abnormal_fetal_cardiomyocyte | 1.54904338 |
| 38 | MP0008877_abnormal_DNA_methylation | 1.51728498 |
| 39 | MP0009697_abnormal_copulation | 1.50799736 |
| 40 | MP0009053_abnormal_anal_canal | 1.46181954 |
| 41 | MP0010030_abnormal_orbit_morphology | 1.43083538 |
| 42 | MP0002009_preneoplasia | 1.41758644 |
| 43 | MP0009278_abnormal_bone_marrow | 1.41540648 |
| 44 | MP0002019_abnormal_tumor_incidence | 1.40564402 |
| 45 | MP0000313_abnormal_cell_death | 1.39895694 |
| 46 | MP0003705_abnormal_hypodermis_morpholog | 1.37732020 |
| 47 | MP0000703_abnormal_thymus_morphology | 1.34736163 |
| 48 | MP0006054_spinal_hemorrhage | 1.32573314 |
| 49 | MP0009333_abnormal_splenocyte_physiolog | 1.31311368 |
| 50 | MP0001293_anophthalmia | 1.27287650 |
| 51 | MP0003763_abnormal_thymus_physiology | 1.26997920 |
| 52 | MP0002398_abnormal_bone_marrow | 1.25919648 |
| 53 | MP0006292_abnormal_olfactory_placode | 1.24895801 |
| 54 | MP0003121_genomic_imprinting | 1.22933941 |
| 55 | MP0000537_abnormal_urethra_morphology | 1.18939015 |
| 56 | MP0003786_premature_aging | 1.16182265 |
| 57 | MP0005083_abnormal_biliary_tract | 1.15655876 |
| 58 | MP0002722_abnormal_immune_system | 1.15168811 |
| 59 | MP0006036_abnormal_mitochondrial_physio | 1.13688271 |
| 60 | MP0001881_abnormal_mammary_gland | 1.07636532 |
| 61 | MP0002132_abnormal_respiratory_system | 1.07419289 |
| 62 | MP0009672_abnormal_birth_weight | 1.06457066 |
| 63 | MP0002249_abnormal_larynx_morphology | 1.03705846 |
| 64 | MP0003186_abnormal_redox_activity | 1.03554217 |
| 65 | MP0003566_abnormal_cell_adhesion | 1.02345939 |
| 66 | MP0000689_abnormal_spleen_morphology | 1.02029159 |
| 67 | MP0000566_synostosis | 1.01885162 |
| 68 | MP0003890_abnormal_embryonic-extraembry | 1.00088469 |
| 69 | MP0005023_abnormal_wound_healing | 0.98151768 |
| 70 | MP0001873_stomach_inflammation | 0.97557427 |
| 71 | MP0005464_abnormal_platelet_physiology | 0.96913427 |
| 72 | MP0001849_ear_inflammation | 0.95312809 |
| 73 | MP0000428_abnormal_craniofacial_morphol | 0.94557017 |
| 74 | MP0000733_abnormal_muscle_development | 0.93617250 |
| 75 | MP0002429_abnormal_blood_cell | 0.92587798 |
| 76 | MP0009703_decreased_birth_body | 0.92445763 |
| 77 | MP0006035_abnormal_mitochondrial_morpho | 0.92217556 |
| 78 | MP0005666_abnormal_adipose_tissue | 0.92019297 |
| 79 | MP0001915_intracranial_hemorrhage | 0.91271200 |
| 80 | MP0000858_altered_metastatic_potential | 0.90846918 |
| 81 | MP0000358_abnormal_cell_content/ | 0.90671336 |
| 82 | MP0002796_impaired_skin_barrier | 0.88820454 |
| 83 | MP0003656_abnormal_erythrocyte_physiolo | 0.87793748 |
| 84 | MP0009931_abnormal_skin_appearance | 0.87270154 |
| 85 | MP0003937_abnormal_limbs/digits/tail_de | 0.85332817 |
| 86 | MP0002210_abnormal_sex_determination | 0.83563279 |
| 87 | MP0003718_maternal_effect | 0.81790702 |
| 88 | MP0000716_abnormal_immune_system | 0.81046633 |
| 89 | MP0003315_abnormal_perineum_morphology | 0.79592068 |
| 90 | MP0002092_abnormal_eye_morphology | 0.79426507 |
| 91 | MP0001346_abnormal_lacrimal_gland | 0.78605756 |
| 92 | MP0003119_abnormal_digestive_system | 0.77881493 |
| 93 | MP0004233_abnormal_muscle_weight | 0.77780912 |
| 94 | MP0001145_abnormal_male_reproductive | 0.77670948 |
| 95 | MP0002925_abnormal_cardiovascular_devel | 0.77439886 |
| 96 | MP0001853_heart_inflammation | 0.77292963 |
| 97 | MP0002111_abnormal_tail_morphology | 0.75901276 |
| 98 | MP0000477_abnormal_intestine_morphology | 0.75824024 |
| 99 | MP0001727_abnormal_embryo_implantation | 0.74826931 |
| 100 | MP0003303_peritoneal_inflammation | 0.74231989 |
| 101 | MP0000685_abnormal_immune_system | 0.73900996 |
| 102 | MP0004185_abnormal_adipocyte_glucose | 0.73446560 |
| 103 | MP0003941_abnormal_skin_development | 0.72935698 |
| 104 | MP0000383_abnormal_hair_follicle | 0.72575085 |
| 105 | MP0005621_abnormal_cell_physiology | 0.72486695 |
| 106 | MP0005501_abnormal_skin_physiology | 0.72108421 |
| 107 | MP0000681_abnormal_thyroid_gland | 0.71832956 |
| 108 | MP0000465_gastrointestinal_hemorrhage | 0.71811701 |
| 109 | MP0004264_abnormal_extraembryonic_tissu | 0.71634483 |
| 110 | MP0002697_abnormal_eye_size | 0.70499390 |
| 111 | MP0002405_respiratory_system_inflammati | 0.70399293 |
| 112 | MP0005384_cellular_phenotype | 0.69786112 |
| 113 | MP0002166_altered_tumor_susceptibility | 0.69458577 |
| 114 | MP0002970_abnormal_white_adipose | 0.69410721 |
| 115 | MP0003935_abnormal_craniofacial_develop | 0.68887924 |
| 116 | MP0001929_abnormal_gametogenesis | 0.68538422 |
| 117 | MP0000432_abnormal_head_morphology | 0.68133962 |
| 118 | MP0000377_abnormal_hair_follicle | 0.67840350 |
| 119 | MP0003115_abnormal_respiratory_system | 0.67411324 |
| 120 | MP0002877_abnormal_melanocyte_morpholog | 0.66541559 |
| 121 | MP0003448_altered_tumor_morphology | 0.66488528 |
| 122 | MP0001800_abnormal_humoral_immune | 0.66462408 |
| 123 | MP0001286_abnormal_eye_development | 0.65320726 |
| 124 | MP0000598_abnormal_liver_morphology | 0.64824603 |
| 125 | MP0008770_decreased_survivor_rate | 0.64804658 |
| 126 | MP0002006_tumorigenesis | 0.64432982 |
| 127 | MP0010630_abnormal_cardiac_muscle | 0.64023902 |
| 128 | MP0002095_abnormal_skin_pigmentation | 0.62952755 |
| 129 | MP0000653_abnormal_sex_gland | 0.62781596 |
| 130 | MP0003943_abnormal_hepatobiliary_system | 0.61850604 |
| 131 | MP0003300_gastrointestinal_ulcer | 0.61769745 |
| 132 | MP0002932_abnormal_joint_morphology | 0.61713025 |
| 133 | MP0002420_abnormal_adaptive_immunity | 0.61142747 |
| 134 | MP0000266_abnormal_heart_morphology | 0.60010812 |
| 135 | MP0001819_abnormal_immune_cell | 0.59639921 |
| 136 | MP0003699_abnormal_female_reproductive | 0.58731671 |
| 137 | MP0005058_abnormal_lysosome_morphology | 0.56348136 |
| 138 | MP0002163_abnormal_gland_morphology | 0.56229884 |
| 139 | MP0003959_abnormal_lean_body | 0.55911653 |
| 140 | MP0002234_abnormal_pharynx_morphology | 0.55570421 |
| 141 | MP0003942_abnormal_urinary_system | 0.53244702 |
| 142 | MP0003385_abnormal_body_wall | 0.52650776 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.06093473 |
| 2 | Reticulocytosis (HP:0001923) | 3.97689081 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 3.96434088 |
| 4 | Reticulocytopenia (HP:0001896) | 3.94165260 |
| 5 | Birth length less than 3rd percentile (HP:0003561) | 3.55655302 |
| 6 | Cholecystitis (HP:0001082) | 3.55649487 |
| 7 | Abnormal gallbladder physiology (HP:0012438) | 3.55649487 |
| 8 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.31520054 |
| 9 | Volvulus (HP:0002580) | 3.28157521 |
| 10 | Selective tooth agenesis (HP:0001592) | 3.15304344 |
| 11 | Chromsome breakage (HP:0040012) | 3.13200231 |
| 12 | Increased nuchal translucency (HP:0010880) | 3.04723121 |
| 13 | Colon cancer (HP:0003003) | 3.03720175 |
| 14 | Proximal placement of thumb (HP:0009623) | 2.97920481 |
| 15 | Truncus arteriosus (HP:0001660) | 2.96532641 |
| 16 | Polycythemia (HP:0001901) | 2.95283575 |
| 17 | Hypertensive crisis (HP:0100735) | 2.92974870 |
| 18 | Progressive muscle weakness (HP:0003323) | 2.92092580 |
| 19 | Medulloblastoma (HP:0002885) | 2.89098022 |
| 20 | Deviation of the thumb (HP:0009603) | 2.85100760 |
| 21 | Abnormal hemoglobin (HP:0011902) | 2.83610862 |
| 22 | Patellar aplasia (HP:0006443) | 2.77110993 |
| 23 | Abnormal number of incisors (HP:0011064) | 2.75913983 |
| 24 | Ependymoma (HP:0002888) | 2.74079815 |
| 25 | Breast hypoplasia (HP:0003187) | 2.70137909 |
| 26 | Hyperthyroidism (HP:0000836) | 2.69734508 |
| 27 | Oral leukoplakia (HP:0002745) | 2.66848219 |
| 28 | Seborrheic dermatitis (HP:0001051) | 2.64600333 |
| 29 | Abnormality of cochlea (HP:0000375) | 2.64181702 |
| 30 | Microvesicular hepatic steatosis (HP:0001414) | 2.62547557 |
| 31 | Abnormality of the fingertips (HP:0001211) | 2.61771492 |
| 32 | Basal cell carcinoma (HP:0002671) | 2.61746147 |
| 33 | Insomnia (HP:0100785) | 2.61622562 |
| 34 | Pallor (HP:0000980) | 2.61544795 |
| 35 | Abnormality of chromosome stability (HP:0003220) | 2.61406658 |
| 36 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.61327947 |
| 37 | Aplastic anemia (HP:0001915) | 2.60858761 |
| 38 | Long eyelashes (HP:0000527) | 2.54482007 |
| 39 | Macrocytic anemia (HP:0001972) | 2.53891392 |
| 40 | Atresia of the external auditory canal (HP:0000413) | 2.53678860 |
| 41 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.53290347 |
| 42 | Ectopic kidney (HP:0000086) | 2.50488414 |
| 43 | Poikilocytosis (HP:0004447) | 2.47092573 |
| 44 | Myelodysplasia (HP:0002863) | 2.42432261 |
| 45 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 2.42245875 |
| 46 | Prominent nose (HP:0000448) | 2.39324717 |
| 47 | Cholelithiasis (HP:0001081) | 2.39167945 |
| 48 | Rhabdomyosarcoma (HP:0002859) | 2.37557782 |
| 49 | Abnormality of the preputium (HP:0100587) | 2.35543134 |
| 50 | Degeneration of anterior horn cells (HP:0002398) | 2.34101166 |
| 51 | Abnormality of the anterior horn cell (HP:0006802) | 2.34101166 |
| 52 | Meckel diverticulum (HP:0002245) | 2.33219367 |
| 53 | Ileus (HP:0002595) | 2.31885973 |
| 54 | Short 4th metacarpal (HP:0010044) | 2.30343368 |
| 55 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.30343368 |
| 56 | Hypoparathyroidism (HP:0000829) | 2.28047172 |
| 57 | Absent thumb (HP:0009777) | 2.27183952 |
| 58 | 11 pairs of ribs (HP:0000878) | 2.26132125 |
| 59 | Ankyloglossia (HP:0010296) | 2.23294546 |
| 60 | Carpal bone hypoplasia (HP:0001498) | 2.21785827 |
| 61 | Abnormality of the ileum (HP:0001549) | 2.21643496 |
| 62 | Septate vagina (HP:0001153) | 2.20765484 |
| 63 | Nonimmune hydrops fetalis (HP:0001790) | 2.15459431 |
| 64 | Small intestinal stenosis (HP:0012848) | 2.14830762 |
| 65 | Duodenal stenosis (HP:0100867) | 2.14830762 |
| 66 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.14361431 |
| 67 | Abnormality of reticulocytes (HP:0004312) | 2.12397594 |
| 68 | Acute myeloid leukemia (HP:0004808) | 2.10118186 |
| 69 | Neoplasm of the pancreas (HP:0002894) | 2.08138094 |
| 70 | Facial hemangioma (HP:0000329) | 2.06826208 |
| 71 | Rough bone trabeculation (HP:0100670) | 2.05531353 |
| 72 | Overlapping toe (HP:0001845) | 2.04800621 |
| 73 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.04747818 |
| 74 | Absent radius (HP:0003974) | 2.03361761 |
| 75 | High pitched voice (HP:0001620) | 2.02258574 |
| 76 | Agnosia (HP:0010524) | 2.02251129 |
| 77 | Trismus (HP:0000211) | 2.01729637 |
| 78 | Missing ribs (HP:0000921) | 2.01379447 |
| 79 | Blepharitis (HP:0000498) | 2.00343841 |
| 80 | Squamous cell carcinoma (HP:0002860) | 2.00081213 |
| 81 | Broad distal phalanx of finger (HP:0009836) | 1.96897807 |
| 82 | Thrombocytosis (HP:0001894) | 1.96264704 |
| 83 | Neoplasm of striated muscle (HP:0009728) | 1.96210120 |
| 84 | Premature graying of hair (HP:0002216) | 1.95788369 |
| 85 | Fatigue (HP:0012378) | 1.95185866 |
| 86 | Neoplasm of the oral cavity (HP:0100649) | 1.94604900 |
| 87 | Rectal prolapse (HP:0002035) | 1.93995646 |
| 88 | Disproportionate tall stature (HP:0001519) | 1.93889999 |
| 89 | Acute lymphatic leukemia (HP:0006721) | 1.93420735 |
| 90 | Hyperacusis (HP:0010780) | 1.92315597 |
| 91 | Tracheoesophageal fistula (HP:0002575) | 1.92203409 |
| 92 | Respiratory difficulties (HP:0002880) | 1.92083561 |
| 93 | Impulsivity (HP:0100710) | 1.91439529 |
| 94 | Abnormality of the tricuspid valve (HP:0001702) | 1.91252540 |
| 95 | Morphological abnormality of the inner ear (HP:0011390) | 1.90895075 |
| 96 | Sparse lateral eyebrow (HP:0005338) | 1.90100799 |
| 97 | Short middle phalanx of the 5th finger (HP:0004220) | 1.89194950 |
| 98 | Pseudobulbar signs (HP:0002200) | 1.88855585 |
| 99 | Abnormal gallbladder morphology (HP:0012437) | 1.88674456 |
| 100 | Broad palm (HP:0001169) | 1.87590166 |
| 101 | Orthostatic hypotension (HP:0001278) | 1.87216390 |
| 102 | Skin tags (HP:0010609) | 1.87132379 |
| 103 | IgM deficiency (HP:0002850) | 1.86594350 |
| 104 | Aplasia involving forearm bones (HP:0009822) | 1.86303844 |
| 105 | Absent forearm bone (HP:0003953) | 1.86303844 |
| 106 | Paralysis (HP:0003470) | 1.86162762 |
| 107 | Cafe-au-lait spot (HP:0000957) | 1.85383389 |
| 108 | Abnormality of glycolysis (HP:0004366) | 1.84603077 |
| 109 | Pancytopenia (HP:0001876) | 1.84546328 |
| 110 | Abnormality of the parietal bone (HP:0002696) | 1.84190616 |
| 111 | Renal duplication (HP:0000075) | 1.82926895 |
| 112 | Agammaglobulinemia (HP:0004432) | 1.82149046 |
| 113 | Deep palmar crease (HP:0006191) | 1.82083343 |
| 114 | Preauricular skin tag (HP:0000384) | 1.81814494 |
| 115 | Panhypogammaglobulinemia (HP:0003139) | 1.81759824 |
| 116 | Progressive external ophthalmoplegia (HP:0000590) | 1.80691031 |
| 117 | Abnormality of the carotid arteries (HP:0005344) | 1.80586391 |
| 118 | Lymphoma (HP:0002665) | 1.79870682 |
| 119 | Abnormality of the gallbladder (HP:0005264) | 1.79748130 |
| 120 | Bowel incontinence (HP:0002607) | 1.79528416 |
| 121 | Abnormality of the duodenum (HP:0002246) | 1.79048489 |
| 122 | Abnormal large intestine physiology (HP:0012700) | 1.77015380 |
| 123 | Patellar dislocation (HP:0002999) | 1.75570008 |
| 124 | Horseshoe kidney (HP:0000085) | 1.74872963 |
| 125 | Triphalangeal thumb (HP:0001199) | 1.74708754 |
| 126 | Cutis marmorata (HP:0000965) | 1.74283784 |
| 127 | Bone marrow hypocellularity (HP:0005528) | 1.73787983 |
| 128 | Rib fusion (HP:0000902) | 1.73509639 |
| 129 | Multiple enchondromatosis (HP:0005701) | 1.73103516 |
| 130 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.72580104 |
| 131 | Gastrointestinal carcinoma (HP:0002672) | 1.72580104 |
| 132 | Increased density of long bones (HP:0006392) | 1.72012948 |
| 133 | Thick lower lip vermilion (HP:0000179) | 1.71884565 |
| 134 | Duplicated collecting system (HP:0000081) | 1.70838482 |
| 135 | Amaurosis fugax (HP:0100576) | 1.70791401 |
| 136 | Abnormality of DNA repair (HP:0003254) | 1.69873394 |
| 137 | Microretrognathia (HP:0000308) | 1.69013169 |
| 138 | Biliary tract neoplasm (HP:0100574) | 1.68600725 |
| 139 | Sloping forehead (HP:0000340) | 1.68303816 |
| 140 | Deep philtrum (HP:0002002) | 1.68274152 |
| 141 | Short thumb (HP:0009778) | 1.68193590 |
| 142 | Supernumerary ribs (HP:0005815) | 1.67525871 |
| 143 | Astrocytoma (HP:0009592) | 1.67361775 |
| 144 | Abnormality of the astrocytes (HP:0100707) | 1.67361775 |
| 145 | Supernumerary bones of the axial skeleton (HP:0009144) | 1.67346963 |
| 146 | Hyperbilirubinemia (HP:0002904) | 1.66773534 |
| 147 | Duplication of thumb phalanx (HP:0009942) | 1.64351773 |
| 148 | Abnormal lung lobation (HP:0002101) | 1.64280350 |
| 149 | Cellular immunodeficiency (HP:0005374) | 1.63985630 |
| 150 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 1.63865700 |
| 151 | Abnormality of the thymus (HP:0000777) | 1.63625084 |
| 152 | Slender long bone (HP:0003100) | 1.63311614 |
| 153 | Recurrent viral infections (HP:0004429) | 1.62586409 |
| 154 | Abnormality of homocysteine metabolism (HP:0010919) | 1.61001512 |
| 155 | Homocystinuria (HP:0002156) | 1.61001512 |
| 156 | Acanthocytosis (HP:0001927) | 1.59566408 |
| 157 | Chronic obstructive pulmonary disease (HP:0006510) | 1.58517541 |
| 158 | Obstructive lung disease (HP:0006536) | 1.58517541 |
| 159 | Increased hepatocellular lipid droplets (HP:0006565) | 1.57492739 |
| 160 | Cellulitis (HP:0100658) | 1.55765791 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.62291738 |
| 2 | CDK12 | 3.30324687 |
| 3 | VRK2 | 3.28614076 |
| 4 | WEE1 | 3.25661269 |
| 5 | NEK2 | 3.19957502 |
| 6 | BUB1 | 3.15835637 |
| 7 | SMG1 | 2.76227108 |
| 8 | EEF2K | 2.47810352 |
| 9 | MAP3K10 | 2.38744222 |
| 10 | PRPF4B | 2.28177814 |
| 11 | EIF2AK1 | 2.18149728 |
| 12 | STK10 | 1.99619551 |
| 13 | TTK | 1.99450280 |
| 14 | RPS6KA4 | 1.93819237 |
| 15 | NME2 | 1.91969924 |
| 16 | CDK7 | 1.91922202 |
| 17 | NEK1 | 1.91842657 |
| 18 | MKNK1 | 1.88970373 |
| 19 | CDK4 | 1.81574110 |
| 20 | RPS6KB2 | 1.81452515 |
| 21 | ACVR1B | 1.76388372 |
| 22 | IRAK3 | 1.69704456 |
| 23 | PLK4 | 1.68862869 |
| 24 | ATR | 1.68585917 |
| 25 | TSSK6 | 1.68420124 |
| 26 | TESK2 | 1.64710767 |
| 27 | SRPK1 | 1.64515220 |
| 28 | MAP4K1 | 1.63066005 |
| 29 | BRSK2 | 1.61928862 |
| 30 | AURKB | 1.59691409 |
| 31 | PLK1 | 1.58995422 |
| 32 | RIPK4 | 1.58626390 |
| 33 | PKN2 | 1.53552824 |
| 34 | ICK | 1.45994790 |
| 35 | DYRK3 | 1.43798881 |
| 36 | MAP3K8 | 1.43791263 |
| 37 | MKNK2 | 1.41567866 |
| 38 | CDK6 | 1.36910331 |
| 39 | TRIB3 | 1.36317007 |
| 40 | BRD4 | 1.36002409 |
| 41 | PASK | 1.34163942 |
| 42 | CHEK1 | 1.33853021 |
| 43 | CHEK2 | 1.30091406 |
| 44 | TAOK2 | 1.24930759 |
| 45 | LRRK2 | 1.24829772 |
| 46 | PAK4 | 1.23549202 |
| 47 | NME1 | 1.22532143 |
| 48 | PBK | 1.20432181 |
| 49 | ALK | 1.17079894 |
| 50 | STK4 | 1.15417493 |
| 51 | ERN1 | 1.14380360 |
| 52 | SCYL2 | 1.13992451 |
| 53 | TAF1 | 1.12810659 |
| 54 | PLK3 | 1.08576004 |
| 55 | TGFBR1 | 1.04257902 |
| 56 | STK3 | 1.01768821 |
| 57 | PIM1 | 1.01346282 |
| 58 | ATM | 1.01036969 |
| 59 | CDK2 | 0.97121225 |
| 60 | BRSK1 | 0.95493600 |
| 61 | KDR | 0.91297482 |
| 62 | AURKA | 0.89573612 |
| 63 | EIF2AK3 | 0.89175134 |
| 64 | MTOR | 0.87801236 |
| 65 | CDK8 | 0.86662585 |
| 66 | MAP3K13 | 0.86098774 |
| 67 | VRK1 | 0.85987333 |
| 68 | TAOK1 | 0.84309877 |
| 69 | LATS1 | 0.84170234 |
| 70 | BRAF | 0.81420922 |
| 71 | KSR2 | 0.81085536 |
| 72 | SIK1 | 0.80528839 |
| 73 | FLT3 | 0.75198382 |
| 74 | BTK | 0.70751996 |
| 75 | PIM2 | 0.70477367 |
| 76 | CSNK2A2 | 0.67698849 |
| 77 | CDK1 | 0.67654499 |
| 78 | MELK | 0.66248635 |
| 79 | MAP2K3 | 0.65450736 |
| 80 | MAP3K11 | 0.63943136 |
| 81 | TLK1 | 0.63874355 |
| 82 | ARAF | 0.59876495 |
| 83 | ZAP70 | 0.58049900 |
| 84 | GRK6 | 0.56996705 |
| 85 | RAF1 | 0.55542908 |
| 86 | PAK2 | 0.54242734 |
| 87 | EPHA2 | 0.52544897 |
| 88 | PAK1 | 0.51748377 |
| 89 | * CSNK2A1 | 0.51121362 |
| 90 | CDK3 | 0.50230942 |
| 91 | CDK11A | 0.49880543 |
| 92 | JAK3 | 0.49877947 |
| 93 | ILK | 0.49135680 |
| 94 | EIF2AK2 | 0.48798117 |
| 95 | HIPK2 | 0.48763928 |
| 96 | CSNK1E | 0.48562623 |
| 97 | AKT2 | 0.46900931 |
| 98 | WNK1 | 0.44789614 |
| 99 | STK16 | 0.44463170 |
| 100 | MAPKAPK3 | 0.42767305 |
| 101 | MAP2K2 | 0.42377027 |
| 102 | MAPK11 | 0.42363825 |
| 103 | DMPK | 0.42277338 |
| 104 | CLK1 | 0.42107640 |
| 105 | TAOK3 | 0.41177878 |
| 106 | MAP3K14 | 0.40445420 |
| 107 | MAPK14 | 0.40140770 |
| 108 | SIK2 | 0.39996721 |
| 109 | PRKDC | 0.39718385 |
| 110 | RPS6KL1 | 0.39679313 |
| 111 | RPS6KC1 | 0.39679313 |
| 112 | MAPKAPK2 | 0.37768307 |
| 113 | MAP3K1 | 0.36202763 |
| 114 | CDK9 | 0.35470676 |
| 115 | WNK4 | 0.35323277 |
| 116 | IRAK4 | 0.34907275 |
| 117 | PTK6 | 0.34896134 |
| 118 | MAPKAPK5 | 0.34655421 |
| 119 | MARK3 | 0.34230191 |
| 120 | CSF1R | 0.33227826 |
| 121 | TEC | 0.33218380 |
| 122 | BLK | 0.32828172 |
| 123 | BMX | 0.32174011 |
| 124 | FGFR1 | 0.32054793 |
| 125 | PRKCI | 0.31806809 |
| 126 | CSNK1D | 0.31317013 |
| 127 | RPS6KA1 | 0.31278669 |
| 128 | AKT1 | 0.31262397 |
| 129 | CAMK1D | 0.31256921 |
| 130 | RPS6KA5 | 0.30891136 |
| 131 | MAPK1 | 0.30237298 |
| 132 | CCNB1 | 0.28018769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.85962336 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.88346617 |
| 3 | Spliceosome_Homo sapiens_hsa03040 | 3.42362557 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.30098485 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.09619364 |
| 6 | RNA transport_Homo sapiens_hsa03013 | 3.06489979 |
| 7 | Cell cycle_Homo sapiens_hsa04110 | 3.01794704 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 2.88978117 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.79836667 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.53813096 |
| 11 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.40396934 |
| 12 | RNA polymerase_Homo sapiens_hsa03020 | 2.14889986 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.04837213 |
| 14 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.00958071 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.00940001 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.99054242 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.84984172 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.84597331 |
| 19 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.76175173 |
| 20 | Proteasome_Homo sapiens_hsa03050 | 1.74733255 |
| 21 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.69804498 |
| 22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.60611893 |
| 23 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.30827411 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.25131056 |
| 25 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.18367918 |
| 26 | Thyroid cancer_Homo sapiens_hsa05216 | 1.16761523 |
| 27 | HTLV-I infection_Homo sapiens_hsa05166 | 1.15407128 |
| 28 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.12091371 |
| 29 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.11127794 |
| 30 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.06870505 |
| 31 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.06682739 |
| 32 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.03272116 |
| 33 | Parkinsons disease_Homo sapiens_hsa05012 | 1.01507302 |
| 34 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.01038773 |
| 35 | Carbon metabolism_Homo sapiens_hsa01200 | 1.00691832 |
| 36 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.00280606 |
| 37 | Huntingtons disease_Homo sapiens_hsa05016 | 0.95854239 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.93684428 |
| 39 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.90800369 |
| 40 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.89198446 |
| 41 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.88802175 |
| 42 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83410721 |
| 43 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.83126378 |
| 44 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.81863296 |
| 45 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.80729189 |
| 46 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.80206949 |
| 47 | Colorectal cancer_Homo sapiens_hsa05210 | 0.77592387 |
| 48 | Purine metabolism_Homo sapiens_hsa00230 | 0.77268531 |
| 49 | Hepatitis B_Homo sapiens_hsa05161 | 0.76492816 |
| 50 | Bladder cancer_Homo sapiens_hsa05219 | 0.76478530 |
| 51 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.74905891 |
| 52 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.73555257 |
| 53 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.69398720 |
| 54 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.68892503 |
| 55 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.68076464 |
| 56 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67977060 |
| 57 | Lysine degradation_Homo sapiens_hsa00310 | 0.67170432 |
| 58 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.66727773 |
| 59 | Prostate cancer_Homo sapiens_hsa05215 | 0.66685924 |
| 60 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.66049855 |
| 61 | Measles_Homo sapiens_hsa05162 | 0.65655923 |
| 62 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.65581858 |
| 63 | Adherens junction_Homo sapiens_hsa04520 | 0.65317069 |
| 64 | Shigellosis_Homo sapiens_hsa05131 | 0.65109122 |
| 65 | Apoptosis_Homo sapiens_hsa04210 | 0.63901869 |
| 66 | Sulfur relay system_Homo sapiens_hsa04122 | 0.63078584 |
| 67 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.62150684 |
| 68 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61048153 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59419663 |
| 70 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.59127496 |
| 71 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.58707555 |
| 72 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.57539544 |
| 73 | Protein export_Homo sapiens_hsa03060 | 0.57504853 |
| 74 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.56840162 |
| 75 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.56795883 |
| 76 | Pathways in cancer_Homo sapiens_hsa05200 | 0.56652797 |
| 77 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.56580024 |
| 78 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.54703324 |
| 79 | Legionellosis_Homo sapiens_hsa05134 | 0.54630562 |
| 80 | Viral myocarditis_Homo sapiens_hsa05416 | 0.54291486 |
| 81 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.50100941 |
| 82 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.48962864 |
| 83 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.48921607 |
| 84 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.48218565 |
| 85 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.47938933 |
| 86 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.47202872 |
| 87 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.47131253 |
| 88 | Leishmaniasis_Homo sapiens_hsa05140 | 0.46196254 |
| 89 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.45673525 |
| 90 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.45469609 |
| 91 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.44300003 |
| 92 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.43776179 |
| 93 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.43334734 |
| 94 | Alzheimers disease_Homo sapiens_hsa05010 | 0.43028239 |
| 95 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.42863189 |
| 96 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.42530191 |
| 97 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.42396604 |
| 98 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.42208396 |
| 99 | Endometrial cancer_Homo sapiens_hsa05213 | 0.41709273 |
| 100 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.40292083 |
| 101 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.40246292 |
| 102 | Influenza A_Homo sapiens_hsa05164 | 0.37293500 |
| 103 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.37238251 |
| 104 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.36744267 |
| 105 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.36702723 |
| 106 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.35629723 |
| 107 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.32909060 |
| 108 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.32569630 |
| 109 | Melanoma_Homo sapiens_hsa05218 | 0.32254854 |
| 110 | Glioma_Homo sapiens_hsa05214 | 0.31526379 |
| 111 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.31487392 |
| 112 | Galactose metabolism_Homo sapiens_hsa00052 | 0.30847316 |
| 113 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.29662679 |
| 114 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.28391521 |
| 115 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.28278570 |
| 116 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.28253260 |
| 117 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.27828003 |
| 118 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.27679028 |
| 119 | Platelet activation_Homo sapiens_hsa04611 | 0.27667847 |
| 120 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.26886089 |
| 121 | Prion diseases_Homo sapiens_hsa05020 | 0.26559340 |
| 122 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.23973365 |
| 123 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.18753911 |
| 124 | Metabolic pathways_Homo sapiens_hsa01100 | 0.16629542 |
| 125 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.15521538 |

