ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.11908846
2	sequestering of actin monomers (GO:0042989)	7.78686317
3	viral transcription (GO:0019083)	7.75231283
4	translational termination (GO:0006415)	7.47086073
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.46650102
6	translational elongation (GO:0006414)	6.43392144
7	protein targeting to ER (GO:0045047)	6.36707698
8	cotranslational protein targeting to membrane (GO:0006613)	6.36647056
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.09094075
10	maturation of SSU-rRNA (GO:0030490)	6.02136795
11	protein localization to endoplasmic reticulum (GO:0070972)	5.91169415
12	ribosomal small subunit biogenesis (GO:0042274)	5.87526925
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.80554868
14	viral life cycle (GO:0019058)	5.71897894
15	cellular protein complex disassembly (GO:0043624)	5.62031017
16	ATP synthesis coupled proton transport (GO:0015986)	5.59877503
17	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.59877503
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.54087373
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.29914389
20	translational initiation (GO:0006413)	5.13976062
21	protein complex disassembly (GO:0043241)	4.72451372
22	macromolecular complex disassembly (GO:0032984)	4.45172061
23	chaperone-mediated protein transport (GO:0072321)	4.38047028
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.27483331
25	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.24406072
26	protein targeting to membrane (GO:0006612)	4.18929187
27	protein neddylation (GO:0045116)	4.15975996
28	respiratory electron transport chain (GO:0022904)	4.02361491
29	electron transport chain (GO:0022900)	4.01090034
30	ribosomal large subunit biogenesis (GO:0042273)	4.00885869
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.90404333
32	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.85805177
33	translation (GO:0006412)	3.80026081
34	mRNA catabolic process (GO:0006402)	3.73387716
35	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.61884816
36	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.56770037
37	otic vesicle formation (GO:0030916)	3.36048956
38	inner mitochondrial membrane organization (GO:0007007)	3.35364208
39	RNA catabolic process (GO:0006401)	3.33479181
40	GPI anchor biosynthetic process (GO:0006506)	3.30618275
41	GPI anchor metabolic process (GO:0006505)	3.24622811
42	tongue development (GO:0043586)	3.14149174
43	intraciliary transport (GO:0042073)	3.07768476
44	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.05244056
45	cytidine deamination (GO:0009972)	3.00606969
46	cytidine metabolic process (GO:0046087)	3.00606969
47	cytidine catabolic process (GO:0006216)	3.00606969
48	proteasome assembly (GO:0043248)	2.97232008
49	CENP-A containing nucleosome assembly (GO:0034080)	2.95499340
50	viral protein processing (GO:0019082)	2.94446724
51	behavioral response to nicotine (GO:0035095)	2.93896490
52	ATP biosynthetic process (GO:0006754)	2.93298284
53	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.91265688
54	lateral sprouting from an epithelium (GO:0060601)	2.87868519
55	chromatin remodeling at centromere (GO:0031055)	2.87491771
56	cellular response to interferon-beta (GO:0035458)	2.84610831
57	DNA deamination (GO:0045006)	2.83199241
58	intra-S DNA damage checkpoint (GO:0031573)	2.82797966
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.82316295
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.79014977
61	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.79014977
62	NADH dehydrogenase complex assembly (GO:0010257)	2.79014977
63	establishment of protein localization to membrane (GO:0090150)	2.76797017
64	sleep (GO:0030431)	2.76673759
65	positive regulation of meiosis (GO:0045836)	2.67440790
66	cGMP biosynthetic process (GO:0006182)	2.66637003
67	protein complex biogenesis (GO:0070271)	2.66053682
68	regulation of meiosis I (GO:0060631)	2.63231830
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62865787
70	mannosylation (GO:0097502)	2.61733492
71	protein targeting (GO:0006605)	2.61630264
72	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.61055345
73	response to interferon-beta (GO:0035456)	2.60237607
74	hydrogen ion transmembrane transport (GO:1902600)	2.59838764
75	cellular response to nicotine (GO:0071316)	2.58587700
76	neuron fate determination (GO:0048664)	2.57531520
77	establishment of protein localization to organelle (GO:0072594)	2.55021073
78	cell proliferation in forebrain (GO:0021846)	2.54760564
79	regulation of vasculogenesis (GO:2001212)	2.54649790
80	regulation of alpha-beta T cell proliferation (GO:0046640)	2.53927073
81	ribonucleoprotein complex biogenesis (GO:0022613)	2.50173462
82	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.49950730
83	midbrain development (GO:0030901)	2.48750669
84	preassembly of GPI anchor in ER membrane (GO:0016254)	2.48726682
85	positive regulation of meiotic cell cycle (GO:0051446)	2.47646534
86	positive regulation of interleukin-17 production (GO:0032740)	2.46055456
87	forebrain neuron differentiation (GO:0021879)	2.41547987
88	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.40849305
89	epithelial cilium movement (GO:0003351)	2.39411199
90	hydrogen transport (GO:0006818)	2.38884489
91	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.38838712
92	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	2.38606122
93	rRNA catabolic process (GO:0016075)	2.37505343
94	proton transport (GO:0015992)	2.36686370
95	cellular component biogenesis (GO:0044085)	2.36289114
96	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.35701702
97	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.35701702
98	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.35701702
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.33626198
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.33108904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.41444257
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.22718635
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71075420
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.64641218
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.23780854
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.85329727
7	VDR_22108803_ChIP-Seq_LS180_Human	2.51471971
8	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.46570937
9	ELK1_19687146_ChIP-ChIP_HELA_Human	2.38462720
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37869496
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.37809214
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.35893227
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30205842
14	MYC_18940864_ChIP-ChIP_HL60_Human	2.17357288
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.11617836
16	FUS_26573619_Chip-Seq_HEK293_Human	2.10208390
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09514773
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.05738256
19	EWS_26573619_Chip-Seq_HEK293_Human	1.98808674
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.93650048
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.93158966
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.92000470
23	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.87196863
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.81724144
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80900134
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.80089898
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77630433
28	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.76523525
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.74871463
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.74212963
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69976235
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.69905767
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.69312732
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51961352
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.50917631
36	P300_19829295_ChIP-Seq_ESCs_Human	1.48878036
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48129973
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.47099657
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.47099657
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45362217
41	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.43935259
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42741496
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40647183
44	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40423261
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.38723107
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38620791
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38620791
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34811316
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.34338581
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33197994
51	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.32835531
52	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.32835531
53	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.32835531
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.32824333
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31308372
56	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29364699
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.28492992
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27701544
59	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27128848
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.26665561
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.25052793
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.24164512
63	HTT_18923047_ChIP-ChIP_STHdh_Human	1.23110545
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22175732
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22175732
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.20409468
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19859891
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18139652
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16254469
70	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.15987567
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11177179
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09282249
73	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.07526555
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.06531681
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06205114
76	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.04228151
77	AR_20517297_ChIP-Seq_VCAP_Human	1.04192717
78	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.03378101
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02334316
80	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.02186442
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01826976
82	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01153498
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00597174
84	ERG_20517297_ChIP-Seq_VCAP_Human	1.00279008
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.96277432
86	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94319812
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93540710
88	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93382199
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91574273
90	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.90884295
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90754313
92	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90252431
93	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.89620538
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.88867583
95	TCF4_22108803_ChIP-Seq_LS180_Human	0.88647881
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.87959147
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.86551172
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.85069984
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.85038266
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84821570

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.37505467
2	MP0003136_yellow_coat_color	4.95535357
3	MP0000372_irregular_coat_pigmentation	4.54733205
4	MP0000566_synostosis	3.29778227
5	MP0005171_absent_coat_pigmentation	3.26264473
6	MP0006292_abnormal_olfactory_placode	3.18388410
7	MP0010030_abnormal_orbit_morphology	2.69106187
8	MP0006072_abnormal_retinal_apoptosis	2.44808149
9	MP0005671_abnormal_response_to	2.27139382
10	MP0002277_abnormal_respiratory_mucosa	2.15490792
11	MP0002138_abnormal_hepatobiliary_system	2.05325692
12	MP0005379_endocrine/exocrine_gland_phen	2.04377220
13	MP0003011_delayed_dark_adaptation	1.97435489
14	MP0005084_abnormal_gallbladder_morpholo	1.87556628
15	MP0002938_white_spotting	1.77352317
16	MP0001873_stomach_inflammation	1.74918941
17	MP0005646_abnormal_pituitary_gland	1.73360545
18	MP0001346_abnormal_lacrimal_gland	1.71649261
19	MP0002102_abnormal_ear_morphology	1.69477214
20	MP0004142_abnormal_muscle_tone	1.62992022
21	MP0008058_abnormal_DNA_repair	1.61281031
22	MP0008961_abnormal_basal_metabolism	1.58682559
23	MP0002876_abnormal_thyroid_physiology	1.56243154
24	MP0008789_abnormal_olfactory_epithelium	1.54045478
25	MP0002928_abnormal_bile_duct	1.47904628
26	MP0001835_abnormal_antigen_presentation	1.44355347
27	MP0005174_abnormal_tail_pigmentation	1.42375999
28	MP0005377_hearing/vestibular/ear_phenot	1.39655525
29	MP0003878_abnormal_ear_physiology	1.39655525
30	MP0004134_abnormal_chest_morphology	1.39629394
31	MP0003880_abnormal_central_pattern	1.37206344
32	MP0001879_abnormal_lymphatic_vessel	1.32443741
33	MP0009250_abnormal_appendicular_skeleto	1.30083489
34	MP0005253_abnormal_eye_physiology	1.29444144
35	MP0002234_abnormal_pharynx_morphology	1.24248075
36	MP0003763_abnormal_thymus_physiology	1.24084367
37	MP0001984_abnormal_olfaction	1.19950500
38	MP0003315_abnormal_perineum_morphology	1.15429234
39	MP0002653_abnormal_ependyma_morphology	1.13104610
40	MP0000579_abnormal_nail_morphology	1.12013739
41	MP0001293_anophthalmia	1.11847545
42	MP0002095_abnormal_skin_pigmentation	1.11759701
43	MP0000631_abnormal_neuroendocrine_gland	1.10824806
44	MP0002163_abnormal_gland_morphology	1.10525000
45	MP0005394_taste/olfaction_phenotype	1.09666559
46	MP0005499_abnormal_olfactory_system	1.09666559
47	MP0002282_abnormal_trachea_morphology	1.07200398
48	MP0003718_maternal_effect	1.06901714
49	MP0005551_abnormal_eye_electrophysiolog	1.06173948
50	MP0001485_abnormal_pinna_reflex	1.03226658
51	MP0003638_abnormal_response/metabolism_	1.00392599
52	MP0005075_abnormal_melanosome_morpholog	1.00156011
53	MP0000383_abnormal_hair_follicle	0.98611068
54	MP0000026_abnormal_inner_ear	0.97844893
55	MP0001800_abnormal_humoral_immune	0.95547737
56	MP0009745_abnormal_behavioral_response	0.94772775
57	MP0005645_abnormal_hypothalamus_physiol	0.91059503
58	MP0009697_abnormal_copulation	0.90224861
59	MP0002148_abnormal_hypersensitivity_rea	0.86993513
60	MP0002736_abnormal_nociception_after	0.83553117
61	MP0000778_abnormal_nervous_system	0.82947638
62	MP0003252_abnormal_bile_duct	0.81080465
63	MP0000647_abnormal_sebaceous_gland	0.80720247
64	MP0004885_abnormal_endolymph	0.80636457
65	MP0001529_abnormal_vocalization	0.79478620
66	MP0001790_abnormal_immune_system	0.79338864
67	MP0005387_immune_system_phenotype	0.79338864
68	MP0001905_abnormal_dopamine_level	0.78666001
69	MP0003119_abnormal_digestive_system	0.78177889
70	MP0008872_abnormal_physiological_respon	0.77271640
71	MP0004742_abnormal_vestibular_system	0.77212921
72	MP0002249_abnormal_larynx_morphology	0.76392236
73	MP0001286_abnormal_eye_development	0.74917746
74	MP0005167_abnormal_blood-brain_barrier	0.74873845
75	MP0000537_abnormal_urethra_morphology	0.73612076
76	MP0002210_abnormal_sex_determination	0.73266467
77	MP0009333_abnormal_splenocyte_physiolog	0.73193703
78	MP0002723_abnormal_immune_serum	0.69909370
79	MP0001929_abnormal_gametogenesis	0.68847061
80	MP0005391_vision/eye_phenotype	0.68222551
81	MP0000462_abnormal_digestive_system	0.67695606
82	MP0002572_abnormal_emotion/affect_behav	0.67476940
83	MP0006276_abnormal_autonomic_nervous	0.67272074
84	MP0000465_gastrointestinal_hemorrhage	0.66809838
85	MP0002822_catalepsy	0.66747161
86	MP0002233_abnormal_nose_morphology	0.66487418
87	MP0008569_lethality_at_weaning	0.66456316
88	MP0003938_abnormal_ear_development	0.65913061
89	MP0001963_abnormal_hearing_physiology	0.64890663
90	MP0002272_abnormal_nervous_system	0.64300807
91	MP0000639_abnormal_adrenal_gland	0.64295318
92	MP0002751_abnormal_autonomic_nervous	0.62978937
93	MP0000703_abnormal_thymus_morphology	0.62830951
94	MP0003698_abnormal_male_reproductive	0.62617207
95	MP0000653_abnormal_sex_gland	0.62385681
96	MP0002933_joint_inflammation	0.62060049
97	MP0005410_abnormal_fertilization	0.61985504
98	MP0009053_abnormal_anal_canal	0.61605938
99	MP0005195_abnormal_posterior_eye	0.61013954
100	MP0001968_abnormal_touch/_nociception	0.60735528

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.84482909
2	Type II lissencephaly (HP:0007260)	4.62585953
3	Abnormality of the parietal bone (HP:0002696)	4.49575356
4	Abnormal number of erythroid precursors (HP:0012131)	4.38834014
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.37443907
6	Increased hepatocellular lipid droplets (HP:0006565)	4.26657834
7	Focal motor seizures (HP:0011153)	4.24751136
8	3-Methylglutaconic aciduria (HP:0003535)	4.16316839
9	Retinal dysplasia (HP:0007973)	3.93239985
10	Lipid accumulation in hepatocytes (HP:0006561)	3.68699408
11	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.52595490
12	Concave nail (HP:0001598)	3.47557196
13	Abnormality of the pons (HP:0007361)	3.45245493
14	Macrocytic anemia (HP:0001972)	3.37044867
15	Abnormality of the labia minora (HP:0012880)	3.28531119
16	Renal Fanconi syndrome (HP:0001994)	3.12228417
17	Mitochondrial inheritance (HP:0001427)	3.11243326
18	Cerebellar dysplasia (HP:0007033)	3.07492782
19	Partial duplication of thumb phalanx (HP:0009944)	2.91151977
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.89992930
21	Septo-optic dysplasia (HP:0100842)	2.89802917
22	Absent septum pellucidum (HP:0001331)	2.89477960
23	Hypoplasia of the pons (HP:0012110)	2.81565270
24	Esophageal atresia (HP:0002032)	2.79416825
25	Increased CSF lactate (HP:0002490)	2.70865064
26	Exertional dyspnea (HP:0002875)	2.68966552
27	Congenital, generalized hypertrichosis (HP:0004540)	2.68691288
28	Pallor (HP:0000980)	2.66256465
29	Abnormality of DNA repair (HP:0003254)	2.65411620
30	Aplastic anemia (HP:0001915)	2.60064471
31	Colon cancer (HP:0003003)	2.57454042
32	Supernumerary bones of the axial skeleton (HP:0009144)	2.56694022
33	Abnormality of midbrain morphology (HP:0002418)	2.55878537
34	Molar tooth sign on MRI (HP:0002419)	2.55878537
35	Short middle phalanx of the 5th finger (HP:0004220)	2.53597778
36	Large for gestational age (HP:0001520)	2.53109070
37	Partial duplication of the phalanx of hand (HP:0009999)	2.47054045
38	Acute necrotizing encephalopathy (HP:0006965)	2.45645321
39	Thyroid-stimulating hormone excess (HP:0002925)	2.41694566
40	Hepatocellular necrosis (HP:0001404)	2.37151294
41	Increased intramyocellular lipid droplets (HP:0012240)	2.37006755
42	Respiratory difficulties (HP:0002880)	2.33769581
43	Calf muscle hypertrophy (HP:0008981)	2.33281046
44	Hepatic necrosis (HP:0002605)	2.31508502
45	Supernumerary ribs (HP:0005815)	2.30175917
46	Cortical visual impairment (HP:0100704)	2.26776951
47	Abnormality of the diencephalon (HP:0010662)	2.26634272
48	Abnormality of the renal collecting system (HP:0004742)	2.22974210
49	Muscle hypertrophy of the lower extremities (HP:0008968)	2.18745513
50	Elevated erythrocyte sedimentation rate (HP:0003565)	2.13848637
51	Duplicated collecting system (HP:0000081)	2.12918058
52	Median cleft lip (HP:0000161)	2.12655460
53	Neonatal respiratory distress (HP:0002643)	2.10838574
54	IgG deficiency (HP:0004315)	2.05909541
55	Abnormality of the septum pellucidum (HP:0007375)	2.04688320
56	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.04457253
57	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.03636731
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.00960957
59	Constricted visual fields (HP:0001133)	2.00484014
60	Metaphyseal dysplasia (HP:0100255)	1.98344150
61	Rib fusion (HP:0000902)	1.94892628
62	Hemiplegia (HP:0002301)	1.94116929
63	Stenosis of the external auditory canal (HP:0000402)	1.93445316
64	Congenital stationary night blindness (HP:0007642)	1.93389659
65	Flat occiput (HP:0005469)	1.93191240
66	Lissencephaly (HP:0001339)	1.92781304
67	Gastrointestinal atresia (HP:0002589)	1.92249733
68	Optic disc pallor (HP:0000543)	1.92043228
69	Midline defect of the nose (HP:0004122)	1.91166889
70	Acute encephalopathy (HP:0006846)	1.91028946
71	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.88992136
72	Short tibia (HP:0005736)	1.88794481
73	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.88766010
74	IgM deficiency (HP:0002850)	1.87503082
75	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.87303515
76	Abnormality of renal resorption (HP:0011038)	1.85939715
77	Parakeratosis (HP:0001036)	1.85351333
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.78892802
79	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78886300
80	Humeroradial synostosis (HP:0003041)	1.78270273
81	Synostosis involving the elbow (HP:0003938)	1.78270273
82	Progressive macrocephaly (HP:0004481)	1.76825182
83	Optic nerve hypoplasia (HP:0000609)	1.76162862
84	Severe combined immunodeficiency (HP:0004430)	1.75381526
85	Increased muscle lipid content (HP:0009058)	1.74862506
86	Pancreatic cysts (HP:0001737)	1.72139264
87	Increased number of teeth (HP:0011069)	1.71569887
88	Abnormality of the 2nd finger (HP:0004100)	1.71144453
89	Oral leukoplakia (HP:0002745)	1.70147785
90	Maternal diabetes (HP:0009800)	1.68795598
91	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.67641899
92	Triphalangeal thumb (HP:0001199)	1.67561147
93	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.64576774
94	Migraine (HP:0002076)	1.64164701
95	Abolished electroretinogram (ERG) (HP:0000550)	1.63978130
96	Vertebral fusion (HP:0002948)	1.63045880
97	Short 4th metacarpal (HP:0010044)	1.62779674
98	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.62779674
99	Non-midline cleft lip (HP:0100335)	1.61832460
100	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.61651048

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	4.20887802
2	TXK	4.20620803
3	VRK2	3.80036231
4	MAPK15	3.07063350
5	ZAK	3.02908518
6	PNCK	2.75871745
7	PASK	2.71909250
8	FGFR2	2.68933426
9	VRK1	2.64788987
10	TLK1	2.50260786
11	CDK19	2.42459038
12	BCKDK	2.08486262
13	ADRBK2	1.81939345
14	MAP3K4	1.75842840
15	TAF1	1.59767648
16	TSSK6	1.51269581
17	ITK	1.47313154
18	MAP3K12	1.43330369
19	NME2	1.42686201
20	KDR	1.40303647
21	MAP2K2	1.39001515
22	INSRR	1.38979875
23	CDC7	1.30901698
24	IRAK4	1.29295518
25	CAMKK2	1.27856509
26	MAP4K1	1.27025527
27	TYRO3	1.25256428
28	CAMK1D	1.21239732
29	MAP4K2	1.20177206
30	MAP2K7	1.16065929
31	WNK4	1.15296919
32	EPHA4	1.12727668
33	STK16	1.11725588
34	BMPR1B	1.11313211
35	CAMK1G	1.07887949
36	WEE1	1.05705573
37	TEC	1.02955516
38	EIF2AK3	1.02127297
39	BUB1	1.01129193
40	BMPR2	1.00870605
41	PINK1	0.95864623
42	NUAK1	0.94616084
43	IKBKE	0.93798330
44	GRK1	0.93250931
45	IKBKB	0.91984782
46	KIT	0.88426066
47	CAMK1	0.84828498
48	EPHB2	0.84314168
49	SYK	0.82996288
50	FRK	0.81221974
51	STK24	0.80824809
52	MKNK1	0.80583767
53	NTRK2	0.79952183
54	EIF2AK2	0.77578263
55	MARK3	0.76427248
56	DYRK2	0.75784143
57	RPS6KA5	0.71943656
58	PRKCQ	0.71556330
59	PLK4	0.69836605
60	PLK3	0.68371326
61	CAMKK1	0.67696081
62	MAPKAPK5	0.65714273
63	WNK3	0.65250634
64	MAP2K4	0.62959473
65	MAP3K11	0.62746097
66	SRPK1	0.62040663
67	TGFBR1	0.60326829
68	FGFR1	0.60318838
69	FLT3	0.59745738
70	OBSCN	0.59117141
71	NME1	0.56892888
72	OXSR1	0.56532816
73	CSNK2A2	0.56452130
74	AURKB	0.54472739
75	STK39	0.53842339
76	CCNB1	0.52874459
77	DYRK3	0.51579444
78	IRAK1	0.50149574
79	MUSK	0.49942094
80	CDK3	0.49767301
81	CSNK2A1	0.49602528
82	TNIK	0.49322463
83	ADRBK1	0.49171034
84	SCYL2	0.47344814
85	CSNK1G2	0.45462840
86	MKNK2	0.45218853
87	CHEK2	0.43751551
88	CSF1R	0.42812368
89	PIK3CG	0.42740740
90	BTK	0.42457232
91	BCR	0.39891502
92	AURKA	0.39542458
93	NEK2	0.39036830
94	MAPK7	0.35382783
95	LCK	0.34649715
96	TRIM28	0.34616773
97	DAPK3	0.34211434
98	CHUK	0.32989616
99	PRKACA	0.31304227
100	MATK	0.29774204

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.15862111
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.36755037
3	Parkinsons disease_Homo sapiens_hsa05012	3.64343970
4	Proteasome_Homo sapiens_hsa03050	3.47488029
5	Alzheimers disease_Homo sapiens_hsa05010	2.64381590
6	Asthma_Homo sapiens_hsa05310	2.50600594
7	Protein export_Homo sapiens_hsa03060	2.43991745
8	Huntingtons disease_Homo sapiens_hsa05016	2.38001604
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.29006281
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.26850596
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.19380292
12	Allograft rejection_Homo sapiens_hsa05330	2.11447176
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.04502848
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.02728752
15	Graft-versus-host disease_Homo sapiens_hsa05332	2.00833563
16	Phototransduction_Homo sapiens_hsa04744	1.88699445
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78210413
18	RNA polymerase_Homo sapiens_hsa03020	1.73533427
19	Type I diabetes mellitus_Homo sapiens_hsa04940	1.68633727
20	Basal transcription factors_Homo sapiens_hsa03022	1.66188846
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.59178223
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.55899168
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.48844024
24	Homologous recombination_Homo sapiens_hsa03440	1.46159765
25	Spliceosome_Homo sapiens_hsa03040	1.41590440
26	RNA degradation_Homo sapiens_hsa03018	1.30919395
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.30878976
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27537208
29	DNA replication_Homo sapiens_hsa03030	1.27265573
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.21779899
31	Sulfur metabolism_Homo sapiens_hsa00920	1.19323043
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.18071627
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13544836
34	Rheumatoid arthritis_Homo sapiens_hsa05323	1.12057790
35	Mismatch repair_Homo sapiens_hsa03430	1.07168235
36	Olfactory transduction_Homo sapiens_hsa04740	1.04290316
37	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96829182
38	Purine metabolism_Homo sapiens_hsa00230	0.91136796
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.89842369
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.88785027
41	Butanoate metabolism_Homo sapiens_hsa00650	0.86703805
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85930016
43	Nicotine addiction_Homo sapiens_hsa05033	0.82289117
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81752030
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76620126
46	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.76364460
47	RNA transport_Homo sapiens_hsa03013	0.71975458
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71404269
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.69046164
50	Retinol metabolism_Homo sapiens_hsa00830	0.68999417
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66865378
52	Propanoate metabolism_Homo sapiens_hsa00640	0.64927190
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.64873772
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62600449
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62186894
56	Taste transduction_Homo sapiens_hsa04742	0.60164935
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.57424888
58	Base excision repair_Homo sapiens_hsa03410	0.57018580
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56575407
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.54180888
61	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.52220146
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52119356
63	Regulation of autophagy_Homo sapiens_hsa04140	0.50932921
64	Peroxisome_Homo sapiens_hsa04146	0.49739281
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49111372
66	Viral myocarditis_Homo sapiens_hsa05416	0.47962144
67	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.47308902
68	Metabolic pathways_Homo sapiens_hsa01100	0.45139146
69	Notch signaling pathway_Homo sapiens_hsa04330	0.45047254
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.41738395
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36746525
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35640421
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35254568
74	Morphine addiction_Homo sapiens_hsa05032	0.33726854
75	Fanconi anemia pathway_Homo sapiens_hsa03460	0.33375013
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.31801826
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.30326412
78	HTLV-I infection_Homo sapiens_hsa05166	0.29221996
79	Amphetamine addiction_Homo sapiens_hsa05031	0.28126124
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27926908
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.25948299
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25786539
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.22903821
84	Legionellosis_Homo sapiens_hsa05134	0.22830532
85	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.22091400
86	ABC transporters_Homo sapiens_hsa02010	0.22031001
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.21060814
88	Glutathione metabolism_Homo sapiens_hsa00480	0.20903697
89	Alcoholism_Homo sapiens_hsa05034	0.20706468
90	Salivary secretion_Homo sapiens_hsa04970	0.19875088
91	Cocaine addiction_Homo sapiens_hsa05030	0.19562207
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.19035053
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.18686400
94	p53 signaling pathway_Homo sapiens_hsa04115	0.18464405
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.16951203
96	Herpes simplex infection_Homo sapiens_hsa05168	0.16722577
97	GABAergic synapse_Homo sapiens_hsa04727	0.15598812
98	Leishmaniasis_Homo sapiens_hsa05140	0.15299268
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.14177847
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.13105018

ANP32BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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