ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.06751240
2	ribosomal small subunit biogenesis (GO:0042274)	6.89591057
3	DNA deamination (GO:0045006)	5.68895709
4	viral transcription (GO:0019083)	5.55380857
5	translational termination (GO:0006415)	5.46930576
6	water-soluble vitamin biosynthetic process (GO:0042364)	5.14243810
7	ncRNA 3-end processing (GO:0043628)	5.11906457
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.74772923
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.74772923
10	NADH dehydrogenase complex assembly (GO:0010257)	4.74772923
11	nonmotile primary cilium assembly (GO:0035058)	4.68179056
12	cellular protein complex localization (GO:0034629)	4.45561991
13	translational elongation (GO:0006414)	4.45537826
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.28906743
15	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.24776228
16	cellular protein complex disassembly (GO:0043624)	4.19897418
17	skeletal muscle tissue regeneration (GO:0043403)	4.19554918
18	cotranslational protein targeting to membrane (GO:0006613)	4.14748625
19	ribosomal large subunit biogenesis (GO:0042273)	4.12275904
20	protein targeting to ER (GO:0045047)	4.11430757
21	viral life cycle (GO:0019058)	4.01822758
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.92867871
23	maternal behavior (GO:0042711)	3.92828877
24	regulation of chronic inflammatory response (GO:0002676)	3.91735817
25	translational initiation (GO:0006413)	3.88769666
26	protein localization to endoplasmic reticulum (GO:0070972)	3.87283891
27	ribonucleoprotein complex biogenesis (GO:0022613)	3.84145799
28	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.72746005
29	tolerance induction (GO:0002507)	3.72544584
30	protein complex disassembly (GO:0043241)	3.72444506
31	regulation of vitamin D biosynthetic process (GO:0060556)	3.70931728
32	maturation of SSU-rRNA (GO:0030490)	3.69538824
33	parental behavior (GO:0060746)	3.65565744
34	response to gravity (GO:0009629)	3.47173153
35	macromolecular complex disassembly (GO:0032984)	3.45666443
36	regulation of DNA methylation (GO:0044030)	3.45089500
37	cellular component biogenesis (GO:0044085)	3.43426561
38	behavioral response to nicotine (GO:0035095)	3.36685156
39	signal peptide processing (GO:0006465)	3.34763227
40	N-terminal protein amino acid modification (GO:0031365)	3.27384556
41	auditory receptor cell differentiation (GO:0042491)	3.26844007
42	regulation of regulatory T cell differentiation (GO:0045589)	3.26050738
43	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.25828736
44	cytidine metabolic process (GO:0046087)	3.25391364
45	cytidine catabolic process (GO:0006216)	3.25391364
46	cytidine deamination (GO:0009972)	3.25391364
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.25007360
48	protein complex biogenesis (GO:0070271)	3.24860113
49	translation (GO:0006412)	3.22310878
50	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.20327278
51	substrate-independent telencephalic tangential migration (GO:0021826)	3.20327278
52	regulation of female gonad development (GO:2000194)	3.17766527
53	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.17659317
54	phenylpropanoid metabolic process (GO:0009698)	3.17314836
55	mature B cell differentiation involved in immune response (GO:0002313)	3.14525285
56	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.14276090
57	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.11006237
58	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.08175895
59	positive regulation of cell fate commitment (GO:0010455)	3.07409820
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.05903875
61	termination of RNA polymerase III transcription (GO:0006386)	3.05903875
62	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.04925690
63	ATP synthesis coupled proton transport (GO:0015986)	3.04925690
64	translesion synthesis (GO:0019985)	3.03532453
65	alternative mRNA splicing, via spliceosome (GO:0000380)	3.03382989
66	myoblast migration (GO:0051451)	3.02603864
67	definitive hemopoiesis (GO:0060216)	3.02167109
68	mRNA catabolic process (GO:0006402)	3.02004106
69	regulation of skeletal muscle contraction (GO:0014819)	2.99091407
70	regulation of isotype switching to IgG isotypes (GO:0048302)	2.98739983
71	mature B cell differentiation (GO:0002335)	2.94934183
72	regulation of timing of cell differentiation (GO:0048505)	2.90675656
73	rRNA processing (GO:0006364)	2.90000464
74	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	2.89374680
75	rRNA metabolic process (GO:0016072)	2.85097419
76	regulation of histone H3-K9 methylation (GO:0051570)	2.85080009
77	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.82451082
78	DNA demethylation (GO:0080111)	2.81868443
79	chaperone-mediated protein transport (GO:0072321)	2.81574270
80	regulation of vitamin metabolic process (GO:0030656)	2.78088514
81	UTP metabolic process (GO:0046051)	2.75403277
82	reflex (GO:0060004)	2.74926418
83	kinetochore organization (GO:0051383)	2.74341669
84	attachment of spindle microtubules to kinetochore (GO:0008608)	2.73448743
85	RNA catabolic process (GO:0006401)	2.69360523
86	ribosome biogenesis (GO:0042254)	2.69306666
87	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.68215476
88	negative regulation of B cell mediated immunity (GO:0002713)	2.68215476
89	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67867583
90	UTP biosynthetic process (GO:0006228)	2.67787341
91	vitamin biosynthetic process (GO:0009110)	2.66705517
92	regulation of sarcomere organization (GO:0060297)	2.63929742
93	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.63907674
94	regulation of centrosome cycle (GO:0046605)	2.63868455
95	positive regulation of defense response to virus by host (GO:0002230)	2.63321387
96	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.62418186
97	regulation of development, heterochronic (GO:0040034)	2.62305386
98	positive regulation by host of viral transcription (GO:0043923)	2.60491215
99	negative regulation of DNA recombination (GO:0045910)	2.58738748
100	positive regulation of tolerance induction (GO:0002645)	2.58546751

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.59867537
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.41945195
3	VDR_22108803_ChIP-Seq_LS180_Human	4.88959439
4	TP63_19390658_ChIP-ChIP_HaCaT_Human	4.14171543
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.99000081
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.91290142
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61416535
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.58204463
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.30423195
10	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	2.25836727
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.20443582
12	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.11997741
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09785730
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09547878
15	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.94482603
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.89910975
17	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.88053695
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.86538564
19	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.86170560
20	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.85046549
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.84405240
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83955510
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80631110
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.75940217
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.74227857
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.72461050
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.68645694
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.67982231
29	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.63734274
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62614155
31	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.55002493
32	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.55002493
33	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.55002493
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54789776
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54660726
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.54379792
37	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.53630853
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53289090
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49338753
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48885283
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46769692
42	EWS_26573619_Chip-Seq_HEK293_Human	1.45570015
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.45356633
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.43000269
45	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.42229689
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.37422720
47	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.36358213
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32720792
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.31611153
50	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.29153986
51	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.29082308
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28408126
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.27703063
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24554994
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23757115
56	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23662405
57	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.22219933
58	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.21008114
59	DROSHA_22980978_ChIP-Seq_HELA_Human	1.19521823
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19280939
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16996395
62	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.14242920
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.13182058
64	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12823184
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11656553
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.11656155
67	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.10770755
68	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10131038
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.09001994
70	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05909217
71	GABP_19822575_ChIP-Seq_HepG2_Human	1.05522564
72	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05511521
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03538134
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03027416
75	PHF8_20622853_ChIP-Seq_HELA_Human	1.00376816
76	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.99655727
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98583406
78	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.98084763
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.92405618
80	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.91361291
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.88788442
82	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.87942257
83	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87358807
84	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.87117344
85	ELF5_23300383_ChIP-Seq_T47D_Human	0.87115458
86	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.87073366
87	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.86895429
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.86843483
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.86255833
90	EGR1_19032775_ChIP-ChIP_M12_Human	0.85913089
91	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85704528
92	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.84163468
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.84129737
94	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.83991105
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.82596314
96	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82543255
97	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.82452088
98	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.79182075
99	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.78243233
100	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.77708694

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	4.72366393
2	MP0009379_abnormal_foot_pigmentation	4.42123038
3	MP0001873_stomach_inflammation	4.40747945
4	MP0003183_abnormal_peptide_metabolism	3.54916342
5	MP0008057_abnormal_DNA_replication	2.82157042
6	MP0001485_abnormal_pinna_reflex	2.55541313
7	MP0008789_abnormal_olfactory_epithelium	2.51943497
8	MP0005377_hearing/vestibular/ear_phenot	2.45637955
9	MP0003878_abnormal_ear_physiology	2.45637955
10	MP0006292_abnormal_olfactory_placode	2.37775027
11	MP0001529_abnormal_vocalization	2.30652009
12	MP0002822_catalepsy	2.16725360
13	MP0002876_abnormal_thyroid_physiology	2.13891395
14	MP0003123_paternal_imprinting	2.12949152
15	MP0002234_abnormal_pharynx_morphology	2.07773407
16	MP0003315_abnormal_perineum_morphology	1.98171242
17	MP0000049_abnormal_middle_ear	1.93505077
18	MP0004145_abnormal_muscle_electrophysio	1.93359987
19	MP0005083_abnormal_biliary_tract	1.91574203
20	MP0002928_abnormal_bile_duct	1.91529463
21	MP0004142_abnormal_muscle_tone	1.70078011
22	MP0001905_abnormal_dopamine_level	1.63684168
23	MP0003938_abnormal_ear_development	1.62245059
24	MP0000465_gastrointestinal_hemorrhage	1.59037227
25	MP0000678_abnormal_parathyroid_gland	1.56376482
26	MP0004742_abnormal_vestibular_system	1.55436639
27	MP0009697_abnormal_copulation	1.49421075
28	MP0003119_abnormal_digestive_system	1.47022980
29	MP0003786_premature_aging	1.45879176
30	MP0001501_abnormal_sleep_pattern	1.44022432
31	MP0005394_taste/olfaction_phenotype	1.41669238
32	MP0005499_abnormal_olfactory_system	1.41669238
33	MP0005174_abnormal_tail_pigmentation	1.40562987
34	MP0003718_maternal_effect	1.39701762
35	MP0000372_irregular_coat_pigmentation	1.37535555
36	MP0003763_abnormal_thymus_physiology	1.36132224
37	MP0002095_abnormal_skin_pigmentation	1.34767746
38	MP0003385_abnormal_body_wall	1.34618569
39	MP0001188_hyperpigmentation	1.27883294
40	MP0004885_abnormal_endolymph	1.26858406
41	MP0009250_abnormal_appendicular_skeleto	1.22251347
42	MP0005647_abnormal_sex_gland	1.22077656
43	MP0000681_abnormal_thyroid_gland	1.21937677
44	MP0003868_abnormal_feces_composition	1.21933278
45	MP0003943_abnormal_hepatobiliary_system	1.21182835
46	MP0009745_abnormal_behavioral_response	1.18692468
47	MP0000703_abnormal_thymus_morphology	1.14833554
48	MP0005646_abnormal_pituitary_gland	1.14477635
49	MP0009672_abnormal_birth_weight	1.13766821
50	MP0009780_abnormal_chondrocyte_physiolo	1.12900438
51	MP0002163_abnormal_gland_morphology	1.09573295
52	MP0002277_abnormal_respiratory_mucosa	1.08741018
53	MP0003937_abnormal_limbs/digits/tail_de	0.98747969
54	MP0003646_muscle_fatigue	0.96625433
55	MP0008007_abnormal_cellular_replicative	0.96107158
56	MP0002210_abnormal_sex_determination	0.95310543
57	MP0003567_abnormal_fetal_cardiomyocyte	0.94383636
58	MP0009333_abnormal_splenocyte_physiolog	0.92983667
59	MP0001502_abnormal_circadian_rhythm	0.89871533
60	MP0000428_abnormal_craniofacial_morphol	0.89494521
61	MP0002138_abnormal_hepatobiliary_system	0.89355357
62	MP0008877_abnormal_DNA_methylation	0.89188525
63	MP0004147_increased_porphyrin_level	0.86784012
64	MP0006072_abnormal_retinal_apoptosis	0.86563182
65	MP0001664_abnormal_digestion	0.86317388
66	MP0002733_abnormal_thermal_nociception	0.83457117
67	MP0004957_abnormal_blastocyst_morpholog	0.83385255
68	MP0001440_abnormal_grooming_behavior	0.81194764
69	MP0002396_abnormal_hematopoietic_system	0.79852663
70	MP0006276_abnormal_autonomic_nervous	0.79848358
71	MP0001727_abnormal_embryo_implantation	0.79710567
72	MP0000653_abnormal_sex_gland	0.78854140
73	MP0008058_abnormal_DNA_repair	0.78669418
74	MP0001849_ear_inflammation	0.76794896
75	MP0001348_abnormal_lacrimal_gland	0.76114204
76	MP0000490_abnormal_crypts_of	0.72908112
77	MP0009053_abnormal_anal_canal	0.71146299
78	MP0001666_abnormal_nutrient_absorption	0.70855446
79	MP0002233_abnormal_nose_morphology	0.70707377
80	MP0001293_anophthalmia	0.69753973
81	MP0000631_abnormal_neuroendocrine_gland	0.69695969
82	MP0001145_abnormal_male_reproductive	0.68727898
83	MP0002572_abnormal_emotion/affect_behav	0.68696277
84	MP0001963_abnormal_hearing_physiology	0.68602412
85	MP0005379_endocrine/exocrine_gland_phen	0.67908236
86	MP0005423_abnormal_somatic_nervous	0.65933384
87	MP0000427_abnormal_hair_cycle	0.65192298
88	MP0004381_abnormal_hair_follicle	0.64530656
89	MP0005408_hypopigmentation	0.64528499
90	MP0003698_abnormal_male_reproductive	0.64077949
91	MP0002653_abnormal_ependyma_morphology	0.62141421
92	MP0002751_abnormal_autonomic_nervous	0.61909783
93	MP0003111_abnormal_nucleus_morphology	0.61710894
94	MP0002938_white_spotting	0.60755837
95	MP0000013_abnormal_adipose_tissue	0.60044785
96	MP0008872_abnormal_physiological_respon	0.59975494
97	MP0010368_abnormal_lymphatic_system	0.58601841
98	MP0005075_abnormal_melanosome_morpholog	0.58565662
99	MP0003942_abnormal_urinary_system	0.58495348
100	MP0001970_abnormal_pain_threshold	0.57909995

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.99783325
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.46027516
3	Supernumerary bones of the axial skeleton (HP:0009144)	4.18113739
4	Hypoplastic ischia (HP:0003175)	3.84862229
5	Abnormality of the parietal bone (HP:0002696)	3.74400974
6	Hypoplasia of the radius (HP:0002984)	3.50393503
7	Hyperglycinemia (HP:0002154)	3.49920650
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.16204285
9	Abnormality of alanine metabolism (HP:0010916)	3.15682960
10	Hyperalaninemia (HP:0003348)	3.15682960
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.15682960
12	Reticulocytopenia (HP:0001896)	3.09785492
13	Abnormality of the ischium (HP:0003174)	3.09569911
14	Acute necrotizing encephalopathy (HP:0006965)	2.94824499
15	Mitochondrial inheritance (HP:0001427)	2.92626986
16	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.90366196
17	Macrocytic anemia (HP:0001972)	2.85921468
18	Abolished electroretinogram (ERG) (HP:0000550)	2.84615641
19	Reduced antithrombin III activity (HP:0001976)	2.74253012
20	Increased hepatocellular lipid droplets (HP:0006565)	2.71783396
21	Synostosis involving the elbow (HP:0003938)	2.70973039
22	Humeroradial synostosis (HP:0003041)	2.70973039
23	Pseudobulbar signs (HP:0002200)	2.69689681
24	Increased CSF lactate (HP:0002490)	2.69359925
25	Acute encephalopathy (HP:0006846)	2.68329371
26	Papilledema (HP:0001085)	2.68166870
27	Acute myeloid leukemia (HP:0004808)	2.62254846
28	Fibular aplasia (HP:0002990)	2.61273880
29	Diplopia (HP:0000651)	2.59555740
30	Abnormality of binocular vision (HP:0011514)	2.59555740
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.54306475
32	Ileus (HP:0002595)	2.53311043
33	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.52500480
34	Supernumerary ribs (HP:0005815)	2.52075891
35	Abnormal protein N-linked glycosylation (HP:0012347)	2.51499118
36	Abnormal protein glycosylation (HP:0012346)	2.51499118
37	Abnormal glycosylation (HP:0012345)	2.51499118
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.51499118
39	Chorioretinal atrophy (HP:0000533)	2.51271221
40	3-Methylglutaconic aciduria (HP:0003535)	2.47877892
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.45328093
42	Renal cortical cysts (HP:0000803)	2.44106347
43	Limb hypertonia (HP:0002509)	2.43127345
44	Type I transferrin isoform profile (HP:0003642)	2.42785548
45	Conical tooth (HP:0000698)	2.41546532
46	Lipid accumulation in hepatocytes (HP:0006561)	2.41128820
47	Hepatocellular necrosis (HP:0001404)	2.40491411
48	Renal Fanconi syndrome (HP:0001994)	2.37592328
49	Progressive macrocephaly (HP:0004481)	2.36801334
50	Increased serum pyruvate (HP:0003542)	2.36500625
51	Forearm undergrowth (HP:0009821)	2.30961348
52	Acute lymphatic leukemia (HP:0006721)	2.30925192
53	Proximal tubulopathy (HP:0000114)	2.28767698
54	Abnormality of macular pigmentation (HP:0008002)	2.26566032
55	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.22311948
56	B lymphocytopenia (HP:0010976)	2.19455134
57	Pallor (HP:0000980)	2.19309321
58	Poor head control (HP:0002421)	2.19134129
59	Pancreatic cysts (HP:0001737)	2.13942122
60	Congenital sensorineural hearing impairment (HP:0008527)	2.13691245
61	Capillary hemangiomas (HP:0005306)	2.11999333
62	Intellectual disability, progressive (HP:0006887)	2.10165271
63	Abnormality of B cell number (HP:0010975)	2.09842597
64	Retinal dysplasia (HP:0007973)	2.08776798
65	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.07973787
66	Cerebral edema (HP:0002181)	2.07620866
67	Abnormality of serine family amino acid metabolism (HP:0010894)	2.04603276
68	Abnormality of glycine metabolism (HP:0010895)	2.04603276
69	Methylmalonic acidemia (HP:0002912)	2.04332013
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.03638905
71	Trigonocephaly (HP:0000243)	2.00229597
72	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.99853718
73	Hypoplasia of the uterus (HP:0000013)	1.99673237
74	Abnormality of the renal cortex (HP:0011035)	1.99392838
75	Abnormality of midbrain morphology (HP:0002418)	1.99358371
76	Molar tooth sign on MRI (HP:0002419)	1.99358371
77	Hepatic necrosis (HP:0002605)	1.98887285
78	Type I diabetes mellitus (HP:0100651)	1.97140581
79	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.94659428
80	Congenital hip dislocation (HP:0001374)	1.93895936
81	Febrile seizures (HP:0002373)	1.93886232
82	Septate vagina (HP:0001153)	1.93662575
83	Abnormality of the columella (HP:0009929)	1.91513352
84	Abnormality of the 2nd finger (HP:0004100)	1.89106724
85	Congenital stationary night blindness (HP:0007642)	1.87963627
86	Abnormality of glycolysis (HP:0004366)	1.87520890
87	Methylmalonic aciduria (HP:0012120)	1.85890328
88	Short middle phalanx of the 5th finger (HP:0004220)	1.85655813
89	Respiratory difficulties (HP:0002880)	1.85412545
90	Cupped ear (HP:0000378)	1.84542152
91	Abnormality of serum amino acid levels (HP:0003112)	1.83881387
92	Abnormality of cells of the erythroid lineage (HP:0012130)	1.81112691
93	Hydroureter (HP:0000072)	1.80915548
94	Triphalangeal thumb (HP:0001199)	1.80526328
95	Increased serum lactate (HP:0002151)	1.80023788
96	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.78828489
97	Progressive cerebellar ataxia (HP:0002073)	1.77934033
98	Cleft eyelid (HP:0000625)	1.75022202
99	Palpebral edema (HP:0100540)	1.74529816
100	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.70562851

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.27629794
2	MAP4K2	5.67197616
3	SCYL2	4.59323188
4	BUB1	3.52457008
5	NME2	3.06410539
6	DMPK	3.03415594
7	MAP4K1	2.89523607
8	TAF1	2.42606533
9	VRK2	2.18458198
10	TNIK	2.08252479
11	TNK2	1.89928099
12	MELK	1.83601605
13	SRPK1	1.83022579
14	MAP3K9	1.79117090
15	STK24	1.69816520
16	FRK	1.59974403
17	NUAK1	1.52530257
18	IRAK4	1.43521689
19	NEK2	1.42848188
20	CHEK2	1.33039360
21	CAMK1D	1.30910315
22	TLK1	1.29601878
23	CCNB1	1.29402818
24	PASK	1.27556396
25	INSRR	1.20366468
26	ILK	1.17721105
27	EIF2AK3	1.15785964
28	PLK4	1.11973653
29	ARAF	1.08053373
30	CDK4	1.03299158
31	EIF2AK2	1.03283943
32	RPS6KA5	1.00745361
33	TYRO3	1.00687600
34	STK16	1.00560446
35	ADRBK2	0.95205702
36	WNK4	0.94062040
37	BMPR1B	0.93690429
38	PHKG2	0.92572292
39	PHKG1	0.92572292
40	IRAK1	0.91491310
41	BLK	0.89206783
42	CAMK1	0.89077742
43	TTK	0.88907350
44	LRRK2	0.85088928
45	BMPR2	0.81491361
46	ZAP70	0.80614844
47	CAMK1G	0.79452202
48	FES	0.77621882
49	MOS	0.76768970
50	CASK	0.73959688
51	WNK3	0.72788232
52	MARK3	0.71460859
53	ITK	0.68005216
54	BTK	0.67099733
55	RPS6KA4	0.61257974
56	WEE1	0.61027620
57	BRAF	0.58337929
58	NEK9	0.57483535
59	MAP3K13	0.56995613
60	CAMKK2	0.56458843
61	GRK1	0.56007462
62	STK4	0.54797384
63	CDK8	0.52806247
64	CLK1	0.51866272
65	CAMKK1	0.51092154
66	TEC	0.50731509
67	EPHB2	0.50289676
68	SIK2	0.48504739
69	CDK3	0.48461118
70	MKNK1	0.48133648
71	VRK1	0.47571811
72	ATR	0.45381478
73	TSSK6	0.44511245
74	HCK	0.43434969
75	OBSCN	0.42563102
76	AURKA	0.41011248
77	CSNK1G1	0.38875404
78	NLK	0.37652919
79	CSNK2A1	0.37646106
80	TGFBR1	0.36978331
81	CSNK2A2	0.35626437
82	RPS6KA6	0.31708445
83	CAMK4	0.31178130
84	MKNK2	0.29072509
85	WNK1	0.28649640
86	CSNK1A1	0.28067159
87	CDK7	0.28015508
88	PRKD3	0.27444280
89	PLK1	0.25706029
90	STK39	0.25690036
91	RAF1	0.22922293
92	ADRBK1	0.22660200
93	RPS6KC1	0.22437203
94	RPS6KL1	0.22437203
95	CSNK1G2	0.22170682
96	STK3	0.21527078
97	CDK1	0.21388028
98	MAP2K2	0.21316204
99	MAPK7	0.20461248
100	OXSR1	0.20269763

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.53337024
2	Base excision repair_Homo sapiens_hsa03410	2.90093771
3	RNA polymerase_Homo sapiens_hsa03020	2.76202221
4	Basal transcription factors_Homo sapiens_hsa03022	2.73362965
5	Nucleotide excision repair_Homo sapiens_hsa03420	2.62229711
6	Nicotine addiction_Homo sapiens_hsa05033	2.54098694
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.35927500
8	Pyrimidine metabolism_Homo sapiens_hsa00240	2.20762038
9	Homologous recombination_Homo sapiens_hsa03440	2.19869335
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16520022
11	DNA replication_Homo sapiens_hsa03030	2.05713127
12	Parkinsons disease_Homo sapiens_hsa05012	2.00953985
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96946953
14	Sulfur metabolism_Homo sapiens_hsa00920	1.91945126
15	RNA degradation_Homo sapiens_hsa03018	1.91944510
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82139608
17	Huntingtons disease_Homo sapiens_hsa05016	1.71490354
18	Spliceosome_Homo sapiens_hsa03040	1.65579790
19	Morphine addiction_Homo sapiens_hsa05032	1.61205285
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.58836366
21	Mismatch repair_Homo sapiens_hsa03430	1.54505183
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.54024359
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53490565
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48903005
25	One carbon pool by folate_Homo sapiens_hsa00670	1.43315058
26	RNA transport_Homo sapiens_hsa03013	1.39624882
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.35513525
28	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33698594
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.32757007
30	Purine metabolism_Homo sapiens_hsa00230	1.28773772
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16934657
32	Taste transduction_Homo sapiens_hsa04742	1.11907220
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.07639615
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.07603168
35	Alcoholism_Homo sapiens_hsa05034	1.05526760
36	GABAergic synapse_Homo sapiens_hsa04727	1.05282361
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.03436754
38	Proteasome_Homo sapiens_hsa03050	0.93322508
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93016931
40	Alzheimers disease_Homo sapiens_hsa05010	0.89970801
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.89072223
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.88110794
43	Glutathione metabolism_Homo sapiens_hsa00480	0.87695263
44	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.86683549
45	Salivary secretion_Homo sapiens_hsa04970	0.79875225
46	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.78680518
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77953427
48	Cholinergic synapse_Homo sapiens_hsa04725	0.77676615
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77640382
50	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.75400044
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73127655
52	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.72994610
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72712536
54	Cocaine addiction_Homo sapiens_hsa05030	0.71833370
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71174740
56	Retinol metabolism_Homo sapiens_hsa00830	0.66347185
57	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.63828686
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62626463
59	Olfactory transduction_Homo sapiens_hsa04740	0.62477078
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61837356
61	Tight junction_Homo sapiens_hsa04530	0.58446699
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.58130630
63	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56897541
64	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56563896
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.53864744
66	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52783908
67	Viral carcinogenesis_Homo sapiens_hsa05203	0.52419770
68	Lysine degradation_Homo sapiens_hsa00310	0.48241219
69	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47538850
70	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.46207562
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45327107
72	Pancreatic secretion_Homo sapiens_hsa04972	0.44294772
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.44181384
74	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.43947806
75	Metabolic pathways_Homo sapiens_hsa01100	0.43344042
76	Insulin secretion_Homo sapiens_hsa04911	0.42849471
77	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40498995
78	Notch signaling pathway_Homo sapiens_hsa04330	0.39869328
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.39585641
80	HTLV-I infection_Homo sapiens_hsa05166	0.39214484
81	Circadian entrainment_Homo sapiens_hsa04713	0.37725595
82	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37178395
83	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37094768
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36953490
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36726027
86	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36671665
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36344996
88	cAMP signaling pathway_Homo sapiens_hsa04024	0.35883704
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35590187
90	Colorectal cancer_Homo sapiens_hsa05210	0.33182284
91	Serotonergic synapse_Homo sapiens_hsa04726	0.32088890
92	Peroxisome_Homo sapiens_hsa04146	0.29229602
93	Cell cycle_Homo sapiens_hsa04110	0.28954671
94	Ras signaling pathway_Homo sapiens_hsa04014	0.28221503
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.27491072
96	Melanoma_Homo sapiens_hsa05218	0.25539375
97	Primary immunodeficiency_Homo sapiens_hsa05340	0.25515395
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.25134116
99	Long-term potentiation_Homo sapiens_hsa04720	0.24452520
100	Dopaminergic synapse_Homo sapiens_hsa04728	0.23670132

ANP32BP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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