ANP32C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003609.70335363
2tolerance induction (GO:0002507)9.44964025
3negative regulation of cardiac muscle hypertrophy (GO:0010614)9.14095104
4negative regulation of glycogen biosynthetic process (GO:0045719)8.98464915
5regulation of oxidative stress-induced neuron death (GO:1903203)8.97561256
6galactose catabolic process (GO:0019388)8.88680796
7N-terminal protein amino acid acetylation (GO:0006474)8.77871525
8regulation of interleukin-12 biosynthetic process (GO:0045075)8.51090310
9regulation of energy homeostasis (GO:2000505)8.27983912
10negative regulation of muscle hypertrophy (GO:0014741)8.27092179
11interleukin-6-mediated signaling pathway (GO:0070102)8.21309363
12membrane tubulation (GO:0097320)8.14535624
13regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00437.87322032
14regulation of cellular respiration (GO:0043457)7.38778923
15negative regulation of glycogen metabolic process (GO:0070874)7.23637773
16protein localization to endosome (GO:0036010)7.13486766
17cellular response to interleukin-6 (GO:0071354)6.54656864
18ribosomal small subunit biogenesis (GO:0042274)6.45825238
19cysteine metabolic process (GO:0006534)6.04560966
20forebrain morphogenesis (GO:0048853)6.02919922
21sequestering of actin monomers (GO:0042989)5.90264176
22protein heterotetramerization (GO:0051290)5.62087605
23response to interleukin-6 (GO:0070741)5.31921752
24ubiquinone biosynthetic process (GO:0006744)5.22392137
25ribonucleoprotein complex biogenesis (GO:0022613)5.11962129
26response to nitrosative stress (GO:0051409)5.06354742
27viral transcription (GO:0019083)5.02915136
28galactose metabolic process (GO:0006012)5.01585534
29ribosome biogenesis (GO:0042254)4.99917925
30ubiquinone metabolic process (GO:0006743)4.89286453
31translational termination (GO:0006415)4.77664409
32spermatid nucleus differentiation (GO:0007289)4.67474427
33ribosomal large subunit biogenesis (GO:0042273)4.50420037
34quinone biosynthetic process (GO:1901663)4.37608770
35valine metabolic process (GO:0006573)4.17115269
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.15668736
37viral life cycle (GO:0019058)4.10248945
38otic vesicle formation (GO:0030916)4.06585124
39L-phenylalanine catabolic process (GO:0006559)4.03409815
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03409815
41regulation of the force of heart contraction (GO:0002026)3.97598517
42N-terminal protein amino acid modification (GO:0031365)3.96289699
43negative regulation of JAK-STAT cascade (GO:0046426)3.91513809
44cotranslational protein targeting to membrane (GO:0006613)3.90112410
45negative regulation of potassium ion transport (GO:0043267)3.89666071
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.88708259
47cellular response to nicotine (GO:0071316)3.84961421
48tyrosine metabolic process (GO:0006570)3.79833373
49protein targeting to ER (GO:0045047)3.78116352
50cellular protein complex disassembly (GO:0043624)3.76088648
51regulation of respiratory gaseous exchange (GO:0043576)3.73212330
52cell proliferation in forebrain (GO:0021846)3.66405220
53translational elongation (GO:0006414)3.65328301
54dendrite development (GO:0016358)3.63531429
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59372155
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57885177
57megakaryocyte development (GO:0035855)3.56647731
58regulation of hypersensitivity (GO:0002883)3.53474858
59protein localization to endoplasmic reticulum (GO:0070972)3.51282798
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50678884
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45941467
62cellular component biogenesis (GO:0044085)3.41758201
63vesicle fusion (GO:0006906)3.40622241
64regulation of proton transport (GO:0010155)3.40614970
65lymph node development (GO:0048535)3.35767645
66regulation of mitochondrial depolarization (GO:0051900)3.34416303
67positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.33052160
68regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.33052160
69L-phenylalanine metabolic process (GO:0006558)3.30953036
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30953036
71positive regulation of T cell apoptotic process (GO:0070234)3.25506329
72protein complex disassembly (GO:0043241)3.25392234
73mucosal-associated lymphoid tissue development (GO:0048537)3.22814423
74Peyers patch development (GO:0048541)3.22814423
75regulation of cardiac muscle hypertrophy (GO:0010611)3.17762678
76negative regulation of translation, ncRNA-mediated (GO:0040033)3.17443003
77regulation of translation, ncRNA-mediated (GO:0045974)3.17443003
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.17443003
79isoprenoid biosynthetic process (GO:0008299)3.09298215
80regulation of muscle hypertrophy (GO:0014743)3.07625758
81superoxide anion generation (GO:0042554)3.05391261
82response to insecticide (GO:0017085)3.05113585
83innate immune response in mucosa (GO:0002227)3.04839713
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.04786471
85maturation of 5.8S rRNA (GO:0000460)3.04588127
86endosome to pigment granule transport (GO:0043485)3.04240399
87endosome to melanosome transport (GO:0035646)3.04240399
88oligosaccharide biosynthetic process (GO:0009312)3.04050677
89activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.03414561
90positive regulation of positive chemotaxis (GO:0050927)3.03388832
91positive regulation of gamma-delta T cell activation (GO:0046645)3.02112301
92regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.00337403
93regulation of gamma-delta T cell differentiation (GO:0045586)3.00018569
94mucosal immune response (GO:0002385)2.98971920
95regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.95813546
96positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.95813546
97regulation of positive chemotaxis (GO:0050926)2.94675506
98macromolecular complex disassembly (GO:0032984)2.93744806
99regulation of mesoderm development (GO:2000380)2.91714692
100ribosomal small subunit assembly (GO:0000028)2.90572532

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.37862897
2SRY_22984422_ChIP-ChIP_TESTIS_Rat3.96291743
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.40796195
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75867219
5DROSHA_22980978_ChIP-Seq_HELA_Human2.70289065
6ZNF274_21170338_ChIP-Seq_K562_Hela2.56516349
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.52128237
8EZH2_22144423_ChIP-Seq_EOC_Human2.51681506
9GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse2.42431615
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.36263057
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32548782
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31615289
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31615289
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31615289
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28968566
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23224034
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.12921047
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99774710
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91093243
20GBX2_23144817_ChIP-Seq_PC3_Human1.87791852
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.85606555
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85544077
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74446317
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71230242
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70290973
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70182624
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.65897082
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65796532
29CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.65178810
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.60292069
31AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56157348
32HTT_18923047_ChIP-ChIP_STHdh_Human1.55717174
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52338648
34RXRA_24833708_ChIP-Seq_LIVER_Mouse1.51939115
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50738879
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50395376
37SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.50325403
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48782659
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46606431
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46606431
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45903705
42EGR1_19032775_ChIP-ChIP_M12_Human1.45871996
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.44890375
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44787042
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43435110
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40197782
47* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37776201
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32316687
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30263697
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29912256
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.28335000
52SCL_19346495_ChIP-Seq_HPC-7_Human1.26880771
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26245641
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23679304
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18368209
56REST_21632747_ChIP-Seq_MESCs_Mouse1.16143842
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14827904
58CBP_20019798_ChIP-Seq_JUKART_Human1.14827904
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12234340
60FUS_26573619_Chip-Seq_HEK293_Human1.11900095
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.10802295
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.08503746
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06138371
64MYC_18940864_ChIP-ChIP_HL60_Human1.05228583
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05136834
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.04848965
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04412151
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02624944
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02475537
70RAC3_21632823_ChIP-Seq_H3396_Human1.01941806
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01808222
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01009820
73SA1_27219007_Chip-Seq_Bcells_Human1.00557589
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99280588
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99056698
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97930744
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96226757
78SMAD3_21741376_ChIP-Seq_HESCs_Human0.96092332
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94097167
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.93088956
81TP53_22573176_ChIP-Seq_HFKS_Human0.92685002
82NANOG_20526341_ChIP-Seq_ESCs_Human0.91907048
83ER_23166858_ChIP-Seq_MCF-7_Human0.91281982
84RUNX_20019798_ChIP-Seq_JUKART_Human0.90552773
85RNF2_27304074_Chip-Seq_ESCs_Mouse0.89506611
86AR_21572438_ChIP-Seq_LNCaP_Human0.88902682
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88060939
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.87957848
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86807618
90SMAD4_21741376_ChIP-Seq_HESCs_Human0.85934093
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85850518
92SOX2_16153702_ChIP-ChIP_HESCs_Human0.85694197
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.85653517
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84198994
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.82121106
96TP53_22127205_ChIP-Seq_IMR90_Human0.82106129
97P300_27268052_Chip-Seq_Bcells_Human0.82040975
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.81819694
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81709683
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.81037599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage9.57833343
2MP0002653_abnormal_ependyma_morphology6.19950294
3MP0002837_dystrophic_cardiac_calcinosis5.78924798
4MP0005623_abnormal_meninges_morphology5.32299848
5MP0004084_abnormal_cardiac_muscle4.75957415
6MP0001348_abnormal_lacrimal_gland3.67155131
7MP0003279_aneurysm3.61101396
8MP0001915_intracranial_hemorrhage3.29722957
9MP0004145_abnormal_muscle_electrophysio2.76253664
10MP0004036_abnormal_muscle_relaxation2.60116613
11MP0009379_abnormal_foot_pigmentation2.45252215
12MP0006292_abnormal_olfactory_placode2.33438302
13MP0004215_abnormal_myocardial_fiber2.17692296
14MP0001986_abnormal_taste_sensitivity2.04387650
15MP0004484_altered_response_of1.97650060
16MP0004130_abnormal_muscle_cell1.97406897
17MP0001346_abnormal_lacrimal_gland1.55869035
18MP0002822_catalepsy1.39792166
19MP0003186_abnormal_redox_activity1.38968131
20MP0002163_abnormal_gland_morphology1.34665568
21MP0001764_abnormal_homeostasis1.33490478
22MP0005379_endocrine/exocrine_gland_phen1.25803428
23MP0003195_calcinosis1.21331401
24MP0009765_abnormal_xenobiotic_induced1.19550789
25MP0008872_abnormal_physiological_respon1.19048071
26MP0001661_extended_life_span1.18065613
27MP0009333_abnormal_splenocyte_physiolog1.15765017
28MP0010155_abnormal_intestine_physiology1.14190606
29MP0003303_peritoneal_inflammation1.12955506
30MP0005220_abnormal_exocrine_pancreas1.10819212
31MP0000767_abnormal_smooth_muscle1.06719831
32MP0003011_delayed_dark_adaptation1.06109054
33MP0002733_abnormal_thermal_nociception1.05696795
34MP0002693_abnormal_pancreas_physiology1.05685872
35MP0003633_abnormal_nervous_system1.03245097
36MP0005448_abnormal_energy_balance1.00988257
37MP0009785_altered_susceptibility_to1.00565126
38MP0001286_abnormal_eye_development0.99407288
39MP0003300_gastrointestinal_ulcer0.95154020
40MP0003878_abnormal_ear_physiology0.93820744
41MP0005377_hearing/vestibular/ear_phenot0.93820744
42MP0002697_abnormal_eye_size0.93465113
43MP0005197_abnormal_uvea_morphology0.92537450
44MP0009250_abnormal_appendicular_skeleto0.92292335
45MP0002972_abnormal_cardiac_muscle0.91016020
46MP0005165_increased_susceptibility_to0.89990400
47MP0003631_nervous_system_phenotype0.89533950
48MP0000678_abnormal_parathyroid_gland0.88568216
49MP0008775_abnormal_heart_ventricle0.83698342
50MP0001340_abnormal_eyelid_morphology0.83051326
51MP0001501_abnormal_sleep_pattern0.82315847
52MP0002272_abnormal_nervous_system0.80942408
53MP0002736_abnormal_nociception_after0.80059265
54MP0001800_abnormal_humoral_immune0.79886354
55MP0002160_abnormal_reproductive_system0.77968213
56MP0001968_abnormal_touch/_nociception0.73570464
57MP0001970_abnormal_pain_threshold0.70198035
58MP0005410_abnormal_fertilization0.70189755
59MP0009046_muscle_twitch0.68210963
60MP0005334_abnormal_fat_pad0.64894770
61MP0010030_abnormal_orbit_morphology0.63726200
62MP0003693_abnormal_embryo_hatching0.62776385
63MP0005423_abnormal_somatic_nervous0.61093537
64MP0002734_abnormal_mechanical_nocicepti0.60335879
65MP0000465_gastrointestinal_hemorrhage0.59180440
66MP0009745_abnormal_behavioral_response0.57992403
67MP0002735_abnormal_chemical_nociception0.56928473
68MP0005266_abnormal_metabolism0.55836882
69MP0005376_homeostasis/metabolism_phenot0.55670993
70MP0005193_abnormal_anterior_eye0.55431126
71MP0002723_abnormal_immune_serum0.54764898
72MP0001905_abnormal_dopamine_level0.54267247
73MP0001544_abnormal_cardiovascular_syste0.53213402
74MP0005385_cardiovascular_system_phenoty0.53213402
75MP0004185_abnormal_adipocyte_glucose0.53008340
76MP0004742_abnormal_vestibular_system0.51341374
77MP0005671_abnormal_response_to0.51269981
78MP0000049_abnormal_middle_ear0.50776282
79MP0002896_abnormal_bone_mineralization0.50731648
80MP0001502_abnormal_circadian_rhythm0.48948072
81MP0005645_abnormal_hypothalamus_physiol0.47411608
82MP0003632_abnormal_nervous_system0.46840942
83MP0002751_abnormal_autonomic_nervous0.46647517
84MP0003880_abnormal_central_pattern0.46633816
85MP0002106_abnormal_muscle_physiology0.45121093
86MP0003724_increased_susceptibility_to0.44643904
87MP0005620_abnormal_muscle_contractility0.44157240
88MP0003959_abnormal_lean_body0.43583149
89MP0003119_abnormal_digestive_system0.43023015
90MP0006276_abnormal_autonomic_nervous0.42456580
91MP0003252_abnormal_bile_duct0.42034289
92MP0000477_abnormal_intestine_morphology0.41634893
93MP0005253_abnormal_eye_physiology0.41337837
94MP0005551_abnormal_eye_electrophysiolog0.39489384
95MP0003646_muscle_fatigue0.38883607
96MP0003936_abnormal_reproductive_system0.38431316
97MP0002116_abnormal_craniofacial_bone0.38194600
98MP0005389_reproductive_system_phenotype0.37793199
99MP0005310_abnormal_salivary_gland0.37736900
100MP0009763_increased_sensitivity_to0.37422774

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)7.78614626
2Absent/shortened dynein arms (HP:0200106)6.09993654
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.09993654
4Mutism (HP:0002300)6.03529994
5Hypergonadotropic hypogonadism (HP:0000815)5.74375744
6Premature ovarian failure (HP:0008209)5.42821153
7Abnormal ciliary motility (HP:0012262)5.22555554
8Abnormal number of erythroid precursors (HP:0012131)4.76670309
9Chronic otitis media (HP:0000389)4.75654341
10Loss of speech (HP:0002371)4.35585397
11Disinhibition (HP:0000734)4.32635769
12Inability to walk (HP:0002540)4.28833676
13Abnormality of cells of the erythroid lineage (HP:0012130)4.27243328
14Dyskinesia (HP:0100660)4.00714340
15Abnormal respiratory motile cilium physiology (HP:0012261)3.95691723
16Renal duplication (HP:0000075)3.84796783
17Abnormal respiratory motile cilium morphology (HP:0005938)3.74199992
18Abnormal respiratory epithelium morphology (HP:0012253)3.74199992
19Aortic regurgitation (HP:0001659)3.65357562
20Anophthalmia (HP:0000528)3.50043250
21Submucous cleft hard palate (HP:0000176)3.47860585
22Progressive muscle weakness (HP:0003323)3.44256260
23Overriding aorta (HP:0002623)3.39075040
24Chronic sinusitis (HP:0011109)3.38681284
25Hepatocellular necrosis (HP:0001404)3.02488701
26Elfin facies (HP:0004428)2.99659011
27Rhinitis (HP:0012384)2.93421372
28Acute necrotizing encephalopathy (HP:0006965)2.75154041
29Renovascular hypertension (HP:0100817)2.72816236
30True hermaphroditism (HP:0010459)2.58724239
31Agammaglobulinemia (HP:0004432)2.56417178
32Stomatitis (HP:0010280)2.50959423
33Apathy (HP:0000741)2.47958908
34Flat cornea (HP:0007720)2.40296228
35Diminished motivation (HP:0000745)2.38640585
36Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.36978832
37Cystic liver disease (HP:0006706)2.34779438
38Abnormal mitochondria in muscle tissue (HP:0008316)2.34611199
39Enlarged epiphyses (HP:0010580)2.34513316
40Restlessness (HP:0000711)2.33877189
41Elevated erythrocyte sedimentation rate (HP:0003565)2.32976487
42Inappropriate behavior (HP:0000719)2.32495114
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.31857410
44Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.31398844
45Hepatic necrosis (HP:0002605)2.27193135
46Pancreatic fibrosis (HP:0100732)2.23946130
47Symphalangism affecting the phalanges of the hand (HP:0009773)2.21479757
48Optic disc pallor (HP:0000543)2.21319303
49Sclerocornea (HP:0000647)2.21006554
50Progressive macrocephaly (HP:0004481)2.20240554
51Rib fusion (HP:0000902)2.14735257
52Hypoplasia of the uterus (HP:0000013)2.14236822
53Progressive cerebellar ataxia (HP:0002073)2.14037244
54Acute encephalopathy (HP:0006846)2.12374932
55Insomnia (HP:0100785)2.12285082
56Abnormality of the phalanges of the 5th finger (HP:0004213)2.11537260
57Bulbous nose (HP:0000414)2.11110588
58Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.10397463
59Short middle phalanx of the 5th finger (HP:0004220)2.08713063
60Drooling (HP:0002307)2.08165864
61Genetic anticipation (HP:0003743)2.06791763
62Pseudobulbar signs (HP:0002200)2.05442650
63Mitochondrial inheritance (HP:0001427)2.05366244
64Excessive salivation (HP:0003781)2.04402870
65Abnormality of alanine metabolism (HP:0010916)2.03627556
66Hyperalaninemia (HP:0003348)2.03627556
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03627556
68Aplasia/hypoplasia of the uterus (HP:0008684)2.02775902
69Chronic hepatic failure (HP:0100626)11.3733199
70Centrally nucleated skeletal muscle fibers (HP:0003687)1.98491793
71Delayed epiphyseal ossification (HP:0002663)1.96789866
72Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94816930
73Adrenal hypoplasia (HP:0000835)1.94721701
74Bony spicule pigmentary retinopathy (HP:0007737)1.94614564
75Personality changes (HP:0000751)1.93134906
76Synostosis of carpal bones (HP:0005048)1.93082868
77Sepsis (HP:0100806)1.91659296
78Hyperacusis (HP:0010780)1.90826945
79Specific learning disability (HP:0001328)1.89195188
80Widely patent fontanelles and sutures (HP:0004492)1.88830777
81Ankle clonus (HP:0011448)1.88769469
82Abnormality of the diencephalon (HP:0010662)1.87723741
83Abnormality of the distal phalanges of the toes (HP:0010182)1.84653961
84Increased serum lactate (HP:0002151)1.83085796
85Pancreatic cysts (HP:0001737)1.81677445
86Sensory axonal neuropathy (HP:0003390)1.81336642
87Adducted thumb (HP:0001181)1.79665632
88Mitral regurgitation (HP:0001653)1.79426599
89Long nose (HP:0003189)1.77037266
90Babinski sign (HP:0003487)1.69489054
91Chronic diarrhea (HP:0002028)1.66674912
92Leukodystrophy (HP:0002415)1.66403992
93Abnormality of macular pigmentation (HP:0008002)1.66340681
94Pallor (HP:0000980)1.65189744
95Abnormality of the costochondral junction (HP:0000919)1.64960456
96Focal motor seizures (HP:0011153)1.61069310
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.60756764
98Macrocytic anemia (HP:0001972)1.60297203
99Action tremor (HP:0002345)1.58744830
100Mesomelia (HP:0003027)1.58263431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K135.79244217
2CAMKK15.50079656
3TXK3.50755235
4RIPK42.87900215
5BRSK22.32948247
6MAP3K142.20311494
7CAMKK22.05355627
8SIK22.05059952
9PASK11.3179965
10MAP4K11.97789391
11LRRK21.72334245
12WNK41.24723833
13DYRK31.17735840
14MAP2K71.16777722
15GRK71.16015743
16JAK31.12366044
17BTK1.03216601
18ZAK1.02623049
19MAP3K40.98965805
20BRSK10.95437461
21NEK10.90105069
22MAP3K70.87642606
23TEC0.87360752
24CSNK1G20.83333717
25CSNK1G30.82521345
26INSRR0.80189990
27CSNK1A1L0.78802012
28ADRBK20.78780541
29SYK0.78415036
30NEK20.75675599
31PAK60.69666640
32PRKCQ0.67007693
33CSNK1G10.64360544
34TYRO30.63424533
35PTK60.60822216
36MAPK130.58905353
37CLK10.57126202
38DYRK20.56540509
39MARK10.56366098
40TSSK60.56146874
41LCK0.56054955
42MST40.55996399
43MAPKAPK30.55101200
44CHUK0.52799431
45IKBKB0.50456473
46ITK0.47158851
47TLK10.46836079
48WNK30.46707492
49PLK40.44869198
50SGK4940.44432991
51SGK2230.44432991
52BMPR1B0.43807819
53CASK0.43305786
54STK390.42380000
55STK380.41956804
56FGR0.41408441
57PRKAA20.36019815
58TIE10.35580558
59ADRBK10.34661701
60MAP3K60.34647910
61PRKCZ0.33546709
62SGK10.31303520
63EPHB20.30861351
64GRK50.30657494
65PRKCD0.30158753
66STK160.29800754
67MARK30.29508189
68STK110.28846243
69GRK10.28134329
70EPHA40.27810064
71STK40.25459271
72YES10.24612902
73OXSR10.24557959
74RPS6KA50.24450969
75CAMK2B0.23750684
76CDC70.23634497
77BCR0.23499374
78FRK0.23499332
79MAP2K40.23304492
80OBSCN0.23070714
81MUSK0.22479503
82ACVR1B0.21417358
83MAP4K20.20863622
84JAK20.20082137
85VRK10.19956563
86PLK10.19677506
87TGFBR10.19240530
88LYN0.19235872
89ERBB20.19106798
90PAK10.19020805
91ZAP700.18593805
92MAPK140.16522301
93MAPK150.15411159
94MATK0.15295671
95UHMK10.14433037
96WEE10.13585755
97CDK140.13328455
98AURKA0.13284123
99PRKCA0.11380152
100MAPKAPK20.10824463

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.38453842
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.36152327
3Ribosome_Homo sapiens_hsa030104.29285711
4Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.01670888
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.82703791
6Cocaine addiction_Homo sapiens_hsa050302.74305302
7Galactose metabolism_Homo sapiens_hsa000522.46232227
8Olfactory transduction_Homo sapiens_hsa047401.83261314
9Amphetamine addiction_Homo sapiens_hsa050311.81245750
10Systemic lupus erythematosus_Homo sapiens_hsa053221.73984115
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68206807
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.65127820
13Insulin secretion_Homo sapiens_hsa049111.55510627
14Steroid biosynthesis_Homo sapiens_hsa001001.51339840
15Phototransduction_Homo sapiens_hsa047441.50182522
16Glycerolipid metabolism_Homo sapiens_hsa005611.41708612
17Nicotine addiction_Homo sapiens_hsa050331.34488743
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31834519
19Rheumatoid arthritis_Homo sapiens_hsa053231.30989075
20Staphylococcus aureus infection_Homo sapiens_hsa051501.30336342
21Thyroid hormone synthesis_Homo sapiens_hsa049181.29031624
22Alcoholism_Homo sapiens_hsa050341.26435838
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24925535
24Tyrosine metabolism_Homo sapiens_hsa003501.23723016
25Morphine addiction_Homo sapiens_hsa050321.23422783
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20871587
27Type I diabetes mellitus_Homo sapiens_hsa049401.19878973
28Type II diabetes mellitus_Homo sapiens_hsa049301.13986760
29Regulation of autophagy_Homo sapiens_hsa041401.12193547
30Glucagon signaling pathway_Homo sapiens_hsa049221.11699468
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.11432127
32Prolactin signaling pathway_Homo sapiens_hsa049171.08248788
33Long-term potentiation_Homo sapiens_hsa047201.06844493
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04266920
35Primary immunodeficiency_Homo sapiens_hsa053401.02913821
36Shigellosis_Homo sapiens_hsa051311.02634629
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98380476
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97441349
39Autoimmune thyroid disease_Homo sapiens_hsa053200.94641494
40Asthma_Homo sapiens_hsa053100.92855599
41Allograft rejection_Homo sapiens_hsa053300.89004572
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88812789
43Nitrogen metabolism_Homo sapiens_hsa009100.88456680
44Graft-versus-host disease_Homo sapiens_hsa053320.83212624
45p53 signaling pathway_Homo sapiens_hsa041150.80208568
46Viral carcinogenesis_Homo sapiens_hsa052030.79210262
47cAMP signaling pathway_Homo sapiens_hsa040240.78203520
48Chemokine signaling pathway_Homo sapiens_hsa040620.77208885
49Taste transduction_Homo sapiens_hsa047420.75142065
50Dopaminergic synapse_Homo sapiens_hsa047280.74209242
51TNF signaling pathway_Homo sapiens_hsa046680.73092024
52TGF-beta signaling pathway_Homo sapiens_hsa043500.72471536
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.71150801
54GABAergic synapse_Homo sapiens_hsa047270.71100109
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.71086182
56Linoleic acid metabolism_Homo sapiens_hsa005910.70671112
57Apoptosis_Homo sapiens_hsa042100.65397798
58Cholinergic synapse_Homo sapiens_hsa047250.64072201
59Serotonergic synapse_Homo sapiens_hsa047260.63081299
60Glutathione metabolism_Homo sapiens_hsa004800.60922643
61Estrogen signaling pathway_Homo sapiens_hsa049150.59711331
62GnRH signaling pathway_Homo sapiens_hsa049120.59337679
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58416824
64T cell receptor signaling pathway_Homo sapiens_hsa046600.54681531
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54532291
66RNA degradation_Homo sapiens_hsa030180.53493136
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52547134
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52282679
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51509967
70PPAR signaling pathway_Homo sapiens_hsa033200.50746726
71Sulfur metabolism_Homo sapiens_hsa009200.50617046
72Pertussis_Homo sapiens_hsa051330.50406837
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47853467
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47318863
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47254608
76Hepatitis B_Homo sapiens_hsa051610.45180627
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.45034580
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43729254
79Prostate cancer_Homo sapiens_hsa052150.42990358
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42448373
81Caffeine metabolism_Homo sapiens_hsa002320.41736143
82Measles_Homo sapiens_hsa051620.39261217
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36434411
84Gastric acid secretion_Homo sapiens_hsa049710.36090942
85Acute myeloid leukemia_Homo sapiens_hsa052210.35221235
86Collecting duct acid secretion_Homo sapiens_hsa049660.34621167
87Calcium signaling pathway_Homo sapiens_hsa040200.34412546
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33882660
89MAPK signaling pathway_Homo sapiens_hsa040100.32528421
90African trypanosomiasis_Homo sapiens_hsa051430.32193954
91Viral myocarditis_Homo sapiens_hsa054160.32060664
92Ether lipid metabolism_Homo sapiens_hsa005650.29741786
93Proteasome_Homo sapiens_hsa030500.28715545
94Retinol metabolism_Homo sapiens_hsa008300.28710230
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28495169
96Wnt signaling pathway_Homo sapiens_hsa043100.28363536
97HTLV-I infection_Homo sapiens_hsa051660.27710511
98Circadian entrainment_Homo sapiens_hsa047130.25893958
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.25437023
100Fat digestion and absorption_Homo sapiens_hsa049750.24193891

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