ANPEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.97016601
2* angiotensin maturation (GO:0002003)8.53937647
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.79060694
4adhesion of symbiont to host cell (GO:0044650)5.75702377
5virion attachment to host cell (GO:0019062)5.75702377
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72736948
7vitamin A metabolic process (GO:0006776)5.61285875
8phospholipid efflux (GO:0033700)5.27197679
9flavonoid metabolic process (GO:0009812)5.11476053
10plasma lipoprotein particle assembly (GO:0034377)5.07325618
11regulation of cholesterol esterification (GO:0010872)5.05556314
12hormone catabolic process (GO:0042447)5.05414142
13adhesion of symbiont to host (GO:0044406)4.94046213
14lipoprotein metabolic process (GO:0042157)4.89868283
15drug catabolic process (GO:0042737)4.89238722
16protein-lipid complex assembly (GO:0065005)4.86442476
17cholesterol efflux (GO:0033344)4.85140311
18regulation of triglyceride catabolic process (GO:0010896)4.75845594
19positive regulation of lipoprotein lipase activity (GO:0051006)4.73851428
20positive regulation of triglyceride lipase activity (GO:0061365)4.73851428
21lipoprotein transport (GO:0042953)4.64410344
22fat-soluble vitamin biosynthetic process (GO:0042362)4.61081198
23regulation of bile acid biosynthetic process (GO:0070857)4.47169318
24very-low-density lipoprotein particle assembly (GO:0034379)4.47150316
25modified amino acid transport (GO:0072337)4.37292151
26digestive system process (GO:0022600)4.23705612
27sterol transport (GO:0015918)4.17688853
28cholesterol transport (GO:0030301)4.17688853
29cholesterol homeostasis (GO:0042632)4.13427373
30peptide catabolic process (GO:0043171)4.11124702
31regulation of vitamin metabolic process (GO:0030656)4.10965746
32glycosphingolipid catabolic process (GO:0046479)4.10640960
33glucose 6-phosphate metabolic process (GO:0051156)4.10533632
34sterol homeostasis (GO:0055092)4.10019428
35reverse cholesterol transport (GO:0043691)4.06622297
36actin filament depolymerization (GO:0030042)4.05138459
37negative regulation of sterol transport (GO:0032372)4.02551036
38negative regulation of cholesterol transport (GO:0032375)4.02551036
39glycolipid catabolic process (GO:0019377)3.98996611
40epoxygenase P450 pathway (GO:0019373)3.93982179
41L-alpha-amino acid transmembrane transport (GO:1902475)3.90157381
42NADH metabolic process (GO:0006734)3.83145585
43regulation of cholesterol homeostasis (GO:2000188)3.82843257
44bile acid and bile salt transport (GO:0015721)3.82592495
45high-density lipoprotein particle remodeling (GO:0034375)3.81967238
46regulation of guanylate cyclase activity (GO:0031282)3.79519957
47digestion (GO:0007586)3.78181375
48regulation of cellular extravasation (GO:0002691)3.75110582
49protein-lipid complex remodeling (GO:0034368)3.66550811
50macromolecular complex remodeling (GO:0034367)3.66550811
51plasma lipoprotein particle remodeling (GO:0034369)3.66550811
52positive regulation of fatty acid biosynthetic process (GO:0045723)3.64733967
53fructose metabolic process (GO:0006000)3.63516674
54low-density lipoprotein particle clearance (GO:0034383)3.52953584
55plasma lipoprotein particle clearance (GO:0034381)3.49359534
56plasma lipoprotein particle organization (GO:0071827)3.45962909
57protein-lipid complex subunit organization (GO:0071825)3.44247711
583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.43068986
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.43068986
60cellular response to hepatocyte growth factor stimulus (GO:0035729)3.40956117
61response to hepatocyte growth factor (GO:0035728)3.40956117
62positive regulation of triglyceride metabolic process (GO:0090208)3.36789023
63diacylglycerol metabolic process (GO:0046339)3.35856928
64ceramide catabolic process (GO:0046514)3.28259743
65phospholipid homeostasis (GO:0055091)3.26420670
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.25903219
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24504659
68regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21089286
69urea cycle (GO:0000050)3.19573821
70urea metabolic process (GO:0019627)3.19573821
71positive regulation of lipid catabolic process (GO:0050996)3.17585052
72* peptide hormone processing (GO:0016486)3.15435068
73sphingomyelin metabolic process (GO:0006684)3.11645449
74antigen processing and presentation of endogenous antigen (GO:0019883)3.11439124
75drinking behavior (GO:0042756)3.11067116
76membrane lipid catabolic process (GO:0046466)3.09808885
77sphingolipid catabolic process (GO:0030149)3.08748967
78bundle of His cell to Purkinje myocyte communication (GO:0086069)3.07266326
79positive regulation of p38MAPK cascade (GO:1900745)3.06559536
80transepithelial transport (GO:0070633)3.04428187
81regulation of systemic arterial blood pressure by hormone (GO:0001990)2.99802318
82regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.99802318
83endocrine process (GO:0050886)2.99802318
84nucleobase catabolic process (GO:0046113)2.99751237
85phenylpropanoid metabolic process (GO:0009698)2.98038539
86lipid homeostasis (GO:0055088)2.97091056
87fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97016031
88negative regulation of digestive system process (GO:0060457)2.96618001
89drug metabolic process (GO:0017144)2.96616273
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.96184963
91UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95288303
92oligosaccharide catabolic process (GO:0009313)2.95215905
93homocysteine metabolic process (GO:0050667)2.94116470
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.93928174
95regulation of vitamin D biosynthetic process (GO:0060556)2.93162669
96regulation of systemic arterial blood pressure (GO:0003073)2.92179249
97regulation of cholesterol transport (GO:0032374)2.91656357
98regulation of sterol transport (GO:0032371)2.91656357
99acylglycerol homeostasis (GO:0055090)2.90913440
100triglyceride homeostasis (GO:0070328)2.90913440
101drug transport (GO:0015893)2.89996200
102sulfur compound transport (GO:0072348)2.88879466
103maintenance of gastrointestinal epithelium (GO:0030277)2.85436960
104nitrogen cycle metabolic process (GO:0071941)2.82781341
105transcytosis (GO:0045056)2.82497726
106regulation of extracellular matrix disassembly (GO:0010715)2.79821260
107sulfate transmembrane transport (GO:1902358)2.78126094
108cyclooxygenase pathway (GO:0019371)2.72930916
109cysteine metabolic process (GO:0006534)2.72410559
110exogenous drug catabolic process (GO:0042738)2.72342593
111positive regulation of pseudopodium assembly (GO:0031274)2.70983440
112regulation of cholesterol storage (GO:0010885)2.70820638
113alpha-linolenic acid metabolic process (GO:0036109)2.70659054
114drug transmembrane transport (GO:0006855)2.70075097
115NIK/NF-kappaB signaling (GO:0038061)2.69205188
116positive regulation of chemokine biosynthetic process (GO:0045080)2.68536446
117immunoglobulin mediated immune response (GO:0016064)2.67538446
118regulation of mononuclear cell migration (GO:0071675)2.67119947
119macrophage activation involved in immune response (GO:0002281)2.65828139
120regulation of cytokine secretion involved in immune response (GO:0002739)2.65344854
121positive regulation of guanylate cyclase activity (GO:0031284)2.64854287
122positive regulation by symbiont of host defense response (GO:0052509)2.64709184
123modulation by symbiont of host defense response (GO:0052031)2.64709184
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.64709184
125modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.64709184
126positive regulation by organism of defense response of other organism involved in symbiotic interact2.64709184
127modulation by symbiont of host immune response (GO:0052553)2.64709184
128positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.64362853
129response to peptidoglycan (GO:0032494)2.64195445
130regulation of interferon-beta biosynthetic process (GO:0045357)2.63515857
131response to hydroperoxide (GO:0033194)2.61142531
132renal system process involved in regulation of blood volume (GO:0001977)2.59854674
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.59199962
134cellular carbohydrate catabolic process (GO:0044275)2.58591581
135thyroid hormone metabolic process (GO:0042403)2.57967621
136eosinophil chemotaxis (GO:0048245)2.55546510
137negative regulation of interleukin-12 production (GO:0032695)2.54914325
138leukotriene metabolic process (GO:0006691)2.54033413
139detection of other organism (GO:0098543)2.52763912
140negative regulation of cell killing (GO:0031342)2.49182096
141negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49182096
142detection of bacterium (GO:0016045)2.47859769
143cellular response to cadmium ion (GO:0071276)2.46509239
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.45774543
145barbed-end actin filament capping (GO:0051016)2.44421462
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43901602
147T-helper 1 type immune response (GO:0042088)2.42536000
148low-density lipoprotein particle remodeling (GO:0034374)2.41332475
149positive regulation of antigen processing and presentation (GO:0002579)2.39930859
150regulation of chemokine biosynthetic process (GO:0045073)2.39186573
151arachidonic acid metabolic process (GO:0019369)2.38819994
152neutrophil activation involved in immune response (GO:0002283)2.37330360
153regulation of antigen processing and presentation (GO:0002577)2.37131252
154regulation of pseudopodium assembly (GO:0031272)2.36154511
155cellular glucuronidation (GO:0052695)2.31835461
156regulation of podosome assembly (GO:0071801)2.30603898
157intestinal cholesterol absorption (GO:0030299)10.7656242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.28960839
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.00930373
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.86672991
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.84164081
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80299794
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.57195322
7* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.66686313
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.58976693
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57552897
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56287449
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44083568
12GATA4_25053715_ChIP-Seq_YYC3_Human2.34777693
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.28510986
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.17363935
15* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16356628
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15673086
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.13489279
18GATA6_25053715_ChIP-Seq_YYC3_Human2.08936464
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05485164
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01510912
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.98913735
22SOX2_20726797_ChIP-Seq_SW620_Human1.96601229
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92591267
24IRF8_27001747_Chip-Seq_BMDM_Mouse1.84816023
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77540035
26* VDR_24763502_ChIP-Seq_THP-1_Human1.76172984
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75493706
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73799376
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72322529
30VDR_21846776_ChIP-Seq_THP-1_Human1.70527932
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.69269885
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67429545
33GATA1_22025678_ChIP-Seq_K562_Human1.64894449
34CLOCK_20551151_ChIP-Seq_293T_Human1.61222922
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58454865
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.54819406
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54376255
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52674787
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.48287992
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47814045
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43735460
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43317210
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41990937
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41860957
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38589010
46CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37795120
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.36453865
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36315063
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35809391
50RACK7_27058665_Chip-Seq_MCF-7_Human1.35367939
51* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35166566
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.34964759
53* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33068531
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32705144
55* GATA2_19941826_ChIP-Seq_K562_Human1.31095002
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29255396
57* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28682885
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27060319
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23537917
60KLF5_25053715_ChIP-Seq_YYC3_Human1.22375221
61* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22169348
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.21031241
63ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19710883
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19275355
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19123029
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.18554386
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15827358
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.15682008
69TCF7_22412390_ChIP-Seq_EML_Mouse1.15462748
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15128930
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13009620
72* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12298525
73ATF3_27146783_Chip-Seq_COLON_Human1.11331688
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10871601
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10730264
76EGR1_19032775_ChIP-ChIP_M12_Human1.10647994
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10543198
78* LXR_22292898_ChIP-Seq_THP-1_Human1.10423599
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10137935
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09999138
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08546717
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07950528
83STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06930131
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05235526
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04629828
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04234148
87* SPI1_23547873_ChIP-Seq_NB4_Human1.03384370
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02891078
89BCL6_27268052_Chip-Seq_Bcells_Human1.02761269
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02551841
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01718418
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01090452
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00678990
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99715582
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99617441
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99474945
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99379872
98* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97817224
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97326276
100KDM2B_26808549_Chip-Seq_DND41_Human0.97147016
101MAF_26560356_Chip-Seq_TH1_Human0.96962883
102SPI1_23127762_ChIP-Seq_K562_Human0.96328368
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94150044
104* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92905122
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92881838
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92461147
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91723416
108RUNX_20019798_ChIP-Seq_JUKART_Human0.90988230
109* GATA1_19941826_ChIP-Seq_K562_Human0.90936057
110* GATA2_21666600_ChIP-Seq_HMVEC_Human0.90475330
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89993298
112CREB1_26743006_Chip-Seq_LNCaP_Human0.87993757
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87058737
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86879133
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.85768568
116* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85643575
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85592289
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83889425
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83620154
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83158379
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.82453594
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81782290
123* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80440727
124VDR_24787735_ChIP-Seq_THP-1_Human0.80292765
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.79879888
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79154035
127TP63_23658742_ChIP-Seq_EP156T_Human0.78604058
128BCOR_27268052_Chip-Seq_Bcells_Human0.78577369
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77537670
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.77429779
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76846697
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.74443438
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.74443438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.25108708
2MP0001666_abnormal_nutrient_absorption5.34609229
3MP0009840_abnormal_foam_cell4.57032802
4MP0002139_abnormal_hepatobiliary_system4.39596602
5MP0005085_abnormal_gallbladder_physiolo3.70387662
6MP0003183_abnormal_peptide_metabolism3.58788052
7MP0008875_abnormal_xenobiotic_pharmacok3.46077112
8MP0003252_abnormal_bile_duct3.06492125
9MP0010329_abnormal_lipoprotein_level3.02623047
10MP0005365_abnormal_bile_salt2.92319792
11MP0004264_abnormal_extraembryonic_tissu2.84134160
12MP0010234_abnormal_vibrissa_follicle2.77794521
13MP0002254_reproductive_system_inflammat2.28426859
14MP0003705_abnormal_hypodermis_morpholog2.26892367
15MP0003191_abnormal_cellular_cholesterol2.26337745
16MP0003724_increased_susceptibility_to2.22377310
17MP0004019_abnormal_vitamin_homeostasis2.17479696
18MP0001835_abnormal_antigen_presentation1.84684296
19MP0003300_gastrointestinal_ulcer1.81313364
20MP0005084_abnormal_gallbladder_morpholo1.78462770
21MP0000462_abnormal_digestive_system1.68225288
22MP0008438_abnormal_cutaneous_collagen1.66278692
23MP0003866_abnormal_defecation1.65257394
24MP0001790_abnormal_immune_system1.61443049
25MP0005387_immune_system_phenotype1.61443049
26MP0005332_abnormal_amino_acid1.52899145
27MP0005000_abnormal_immune_tolerance1.49300179
28MP0000609_abnormal_liver_physiology1.43885189
29MP0002998_abnormal_bone_remodeling1.42534421
30MP0004510_myositis1.40637820
31MP0000538_abnormal_urinary_bladder1.40424937
32MP0010352_gastrointestinal_tract_polyps1.39183162
33MP0009643_abnormal_urine_homeostasis1.36690734
34MP0002118_abnormal_lipid_homeostasis1.36625726
35MP0003806_abnormal_nucleotide_metabolis1.34832432
36MP0005058_abnormal_lysosome_morphology1.34403044
37MP0000685_abnormal_immune_system1.32613824
38MP0000604_amyloidosis1.30338087
39MP0010155_abnormal_intestine_physiology1.30102569
40MP0005448_abnormal_energy_balance1.30037244
41MP0004947_skin_inflammation1.29813216
42MP0005409_darkened_coat_color1.29364761
43MP0006082_CNS_inflammation1.26256229
44MP0004147_increased_porphyrin_level1.24322511
45MP0005671_abnormal_response_to1.23025834
46MP0008004_abnormal_stomach_pH1.22426767
47MP0003448_altered_tumor_morphology1.22008349
48MP0009379_abnormal_foot_pigmentation1.21333635
49MP0005083_abnormal_biliary_tract1.20569264
50MP0003436_decreased_susceptibility_to1.18378574
51MP0000343_altered_response_to1.18367162
52MP0000858_altered_metastatic_potential1.15261410
53MP0002723_abnormal_immune_serum1.14819595
54MP0001800_abnormal_humoral_immune1.14587384
55* MP0002452_abnormal_antigen_presenting1.14334676
56MP0008260_abnormal_autophagy1.11241682
57MP0005319_abnormal_enzyme/_coenzyme1.10225057
58MP0002796_impaired_skin_barrier1.09175354
59MP0003279_aneurysm1.07504175
60MP0005167_abnormal_blood-brain_barrier1.06471216
61MP0001663_abnormal_digestive_system1.05490435
62MP0003091_abnormal_cell_migration1.05268370
63MP0005381_digestive/alimentary_phenotyp1.03547545
64MP0001958_emphysema1.03495615
65MP0001664_abnormal_digestion1.02138129
66MP0002822_catalepsy1.01469441
67MP0000477_abnormal_intestine_morphology0.98745287
68MP0001849_ear_inflammation0.98417196
69MP0009333_abnormal_splenocyte_physiolog0.98142414
70MP0005377_hearing/vestibular/ear_phenot0.97686991
71MP0003878_abnormal_ear_physiology0.97686991
72MP0003329_amyloid_beta_deposits0.97558805
73* MP0001819_abnormal_immune_cell0.96750860
74MP0005164_abnormal_response_to0.96123263
75* MP0002420_abnormal_adaptive_immunity0.95084629
76MP0000678_abnormal_parathyroid_gland0.94786757
77MP0001873_stomach_inflammation0.94688471
78MP0005464_abnormal_platelet_physiology0.91814708
79MP0004043_abnormal_pH_regulation0.91772724
80MP0005166_decreased_susceptibility_to0.90839997
81MP0006054_spinal_hemorrhage0.89166814
82MP0009764_decreased_sensitivity_to0.88085413
83MP0002089_abnormal_postnatal_growth/wei0.87967017
84MP0002896_abnormal_bone_mineralization0.87036302
85MP0003303_peritoneal_inflammation0.85634754
86MP0009278_abnormal_bone_marrow0.84740150
87MP0008469_abnormal_protein_level0.84544056
88MP0003879_abnormal_hair_cell0.83665250
89MP0005584_abnormal_enzyme/coenzyme_acti0.83474877
90MP0002136_abnormal_kidney_physiology0.81846196
91MP0005310_abnormal_salivary_gland0.81183298
92MP0005390_skeleton_phenotype0.79439349
93MP0000537_abnormal_urethra_morphology0.79116447
94MP0002405_respiratory_system_inflammati0.78751672
95MP0000490_abnormal_crypts_of0.75771248
96MP0003828_pulmonary_edema0.74947382
97MP0001533_abnormal_skeleton_physiology0.74668471
98MP0000465_gastrointestinal_hemorrhage0.74512073
99MP0009697_abnormal_copulation0.72676677
100MP0003453_abnormal_keratinocyte_physiol0.71811417
101MP0005451_abnormal_body_composition0.71321366
102MP0001845_abnormal_inflammatory_respons0.70477989
103MP0001881_abnormal_mammary_gland0.70255870
104MP0005257_abnormal_intraocular_pressure0.69230910
105MP0005025_abnormal_response_to0.69118601
106MP0000598_abnormal_liver_morphology0.68896928
107MP0002098_abnormal_vibrissa_morphology0.68820026
108MP0009642_abnormal_blood_homeostasis0.68071652
109MP0003656_abnormal_erythrocyte_physiolo0.67833454
110MP0001764_abnormal_homeostasis0.67752939
111MP0003868_abnormal_feces_composition0.67575702
112MP0010678_abnormal_skin_adnexa0.67074778
113MP0002148_abnormal_hypersensitivity_rea0.66433770
114MP0005023_abnormal_wound_healing0.64918870
115MP0009785_altered_susceptibility_to0.64768012
116MP0003638_abnormal_response/metabolism_0.64200006
117MP0009765_abnormal_xenobiotic_induced0.63574330
118MP0005636_abnormal_mineral_homeostasis0.61137791
119MP0009115_abnormal_fat_cell0.61053533
120* MP0002419_abnormal_innate_immunity0.60707828
121MP0001756_abnormal_urination0.59594269
122MP0002876_abnormal_thyroid_physiology0.56285624
123MP0009053_abnormal_anal_canal0.55639258
124MP0004858_abnormal_nervous_system0.54770761
125MP0000249_abnormal_blood_vessel0.54530949
126MP0005501_abnormal_skin_physiology0.54406818
127MP0001765_abnormal_ion_homeostasis0.53259077
128MP0003075_altered_response_to0.53157411
129MP0002138_abnormal_hepatobiliary_system0.52772819
130MP0005367_renal/urinary_system_phenotyp0.52729716
131MP0000516_abnormal_urinary_system0.52729716
132MP0005376_homeostasis/metabolism_phenot0.52721855
133MP0004782_abnormal_surfactant_physiolog0.52055658
134MP0010307_abnormal_tumor_latency0.51465661
135MP0005266_abnormal_metabolism0.51424209
136MP0003172_abnormal_lysosome_physiology0.51148678

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)6.88272922
2Hypobetalipoproteinemia (HP:0003563)6.43618562
3Ileus (HP:0002595)5.66998031
4Acanthocytosis (HP:0001927)5.52765418
5Abnormality of proline metabolism (HP:0010907)5.39139321
6Hydroxyprolinuria (HP:0003080)5.39139321
7Autoimmune thrombocytopenia (HP:0001973)5.18399926
8Malnutrition (HP:0004395)4.68346368
9Conjugated hyperbilirubinemia (HP:0002908)4.58890198
10Fat malabsorption (HP:0002630)4.44815341
11Xanthomatosis (HP:0000991)4.27160412
12Hypolipoproteinemia (HP:0010981)4.19351939
13Hyperglycinuria (HP:0003108)3.75638586
14Right ventricular cardiomyopathy (HP:0011663)3.72503563
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63552706
16Hypercholesterolemia (HP:0003124)3.57286210
17Abnormality of glycolipid metabolism (HP:0010969)3.55281897
18Abnormality of liposaccharide metabolism (HP:0010968)3.55281897
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.55281897
20Intrahepatic cholestasis (HP:0001406)3.54439303
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.53004891
22Pigmentary retinal degeneration (HP:0001146)3.49233366
23Epidermoid cyst (HP:0200040)3.31128466
24Poikilocytosis (HP:0004447)3.30813405
25Cupped ribs (HP:0000887)3.27954650
26Widely patent fontanelles and sutures (HP:0004492)3.17004075
27Abnormality of purine metabolism (HP:0004352)3.02799833
28Abnormality of complement system (HP:0005339)3.02104321
29Potter facies (HP:0002009)2.98668431
30Facial shape deformation (HP:0011334)2.98668431
31Abnormality of sulfur amino acid metabolism (HP:0004339)2.96453608
32Abdominal distention (HP:0003270)2.95699982
33Systemic lupus erythematosus (HP:0002725)2.95124462
34Chronic diarrhea (HP:0002028)2.92705993
35Autoimmune hemolytic anemia (HP:0001890)2.81497957
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.75016177
37Abnormality of glycine metabolism (HP:0010895)2.73591934
38Abnormality of serine family amino acid metabolism (HP:0010894)2.73591934
39Vacuolated lymphocytes (HP:0001922)2.66097342
40Orchitis (HP:0100796)2.64947627
41Reticulocytosis (HP:0001923)2.64769648
42Recurrent abscess formation (HP:0002722)2.63728888
43Nephrolithiasis (HP:0000787)2.60874747
44Hemorrhage of the eye (HP:0011885)2.57949840
45Increased mean platelet volume (HP:0011877)2.55215330
46Recurrent bacterial skin infections (HP:0005406)2.55210378
47Abnormality of nucleobase metabolism (HP:0010932)2.53883291
48Myositis (HP:0100614)2.53541657
49Gingivitis (HP:0000230)2.52204045
50Increased IgE level (HP:0003212)2.49140548
51Amyloidosis (HP:0011034)2.48083030
52Skin nodule (HP:0200036)2.42179480
53Polycythemia (HP:0001901)2.32220517
54Abnormal platelet volume (HP:0011876)2.31993958
55Gastrointestinal dysmotility (HP:0002579)2.31189270
56Mesangial abnormality (HP:0001966)2.29790456
57Increased cerebral lipofuscin (HP:0011813)2.28370274
58Peritonitis (HP:0002586)2.27635489
59Abnormality of urine glucose concentration (HP:0011016)2.27550317
60Glycosuria (HP:0003076)2.27550317
61Petechiae (HP:0000967)2.26471827
62Hypoalphalipoproteinemia (HP:0003233)2.26352638
63Protrusio acetabuli (HP:0003179)2.25072918
64Abnormal glucose tolerance (HP:0001952)2.24638171
65Myocardial infarction (HP:0001658)2.23781442
66Nausea (HP:0002018)2.23463237
67Dehydration (HP:0001944)2.23059422
68Premature rupture of membranes (HP:0001788)2.22513567
69Vertebral compression fractures (HP:0002953)2.20842776
70Urinary glycosaminoglycan excretion (HP:0003541)2.20486269
71Mucopolysacchariduria (HP:0008155)2.20486269
72Pustule (HP:0200039)2.20103195
73Axonal loss (HP:0003447)2.19391065
74Hyperammonemia (HP:0001987)2.18246525
75Peripheral demyelination (HP:0011096)2.17708330
76Hyperparathyroidism (HP:0000843)2.17467856
77Esophageal varix (HP:0002040)2.17449916
78Alopecia of scalp (HP:0002293)2.16108101
79Spontaneous hematomas (HP:0007420)2.13935714
80Bone pain (HP:0002653)2.12525110
81Abnormality of macrophages (HP:0004311)2.09485147
82Purpura (HP:0000979)2.07611677
83Deep venous thrombosis (HP:0002625)2.05477814
84Flat acetabular roof (HP:0003180)2.04932514
85Metaphyseal irregularity (HP:0003025)2.04763183
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04644400
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04644400
88Abnormality of polysaccharide metabolism (HP:0011012)2.04644400
89Abnormal platelet function (HP:0011869)2.03892567
90Impaired platelet aggregation (HP:0003540)2.03892567
91Nephritis (HP:0000123)2.01981542
92Metabolic acidosis (HP:0001942)2.01440962
93Hypophosphatemia (HP:0002148)2.00163396
94Abnormality of transition element cation homeostasis (HP:0011030)1.99529479
95Complement deficiency (HP:0004431)1.98534141
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.98323984
97Hematochezia (HP:0002573)1.97936937
98Abnormality of the costochondral junction (HP:0000919)1.95907750
99Chronic obstructive pulmonary disease (HP:0006510)1.95883730
100Obstructive lung disease (HP:0006536)1.95883730
101Increased neuronal autofluorescent lipopigment (HP:0002074)1.95370653
102Retrobulbar optic neuritis (HP:0100654)1.95146440
103Optic neuritis (HP:0100653)1.95146440
104Abnormality of vitamin metabolism (HP:0100508)1.94438767
105Cervical subluxation (HP:0003308)1.91398070
106Emphysema (HP:0002097)1.90792864
107Steatorrhea (HP:0002570)1.90589120
108Vasculitis (HP:0002633)1.90347180
109Pulmonary infiltrates (HP:0002113)1.90136661
110Segmental peripheral demyelination/remyelination (HP:0003481)1.90055658
111Confusion (HP:0001289)1.89200013
112Pancreatitis (HP:0001733)1.88263642
113Abnormality of vitamin B metabolism (HP:0004340)1.88214002
114Abnormality of alkaline phosphatase activity (HP:0004379)1.88086941
115Abnormal enzyme/coenzyme activity (HP:0012379)1.87203273
116Abnormality of the common coagulation pathway (HP:0010990)1.87129079
117Sensorimotor neuropathy (HP:0007141)1.86950439
118Gastrointestinal infarctions (HP:0005244)1.86222431
119Wide cranial sutures (HP:0010537)1.85518864
120Recurrent gram-negative bacterial infections (HP:0005420)1.85274989
121Hyperbilirubinemia (HP:0002904)1.84683547
122Protuberant abdomen (HP:0001538)1.84609195
123Eczematoid dermatitis (HP:0000976)1.84606243
124Mildly elevated creatine phosphokinase (HP:0008180)1.84066052
125Dysostosis multiplex (HP:0000943)1.83125775
126Elevated alkaline phosphatase (HP:0003155)1.82744769
127Hemoptysis (HP:0002105)1.82337161
128Elevated erythrocyte sedimentation rate (HP:0003565)1.80998340
129Villous atrophy (HP:0011473)1.80649769
130Abnormality of small intestinal villus morphology (HP:0011472)1.80649769
131Mediastinal lymphadenopathy (HP:0100721)1.79708883
132Glomerulonephritis (HP:0000099)1.79574464
133Increased serum ferritin (HP:0003281)1.79297357
134Disinhibition (HP:0000734)1.78738952
135Neurofibrillary tangles (HP:0002185)1.78574283
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77841308
137Enlarged epiphyses (HP:0010580)1.77500828
138Abnormality of the nasal mucosa (HP:0000433)1.75982034
139Loss of speech (HP:0002371)1.75268408
140Abnormality of the vasculature of the conjunctiva (HP:0008054)1.74970866
141Thin bony cortex (HP:0002753)1.72770526
142Gingival bleeding (HP:0000225)1.71911121
143Hypoglycemic coma (HP:0001325)1.70667395
144Premature loss of primary teeth (HP:0006323)1.70236723
145Cheilitis (HP:0100825)1.67676874
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67021376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68586776
2MST44.61480006
3ERN14.24618295
4ACVR1B3.56630582
5GRK63.48311844
6MST1R3.45445710
7AKT32.97412458
8RIPK12.86815268
9PRKG22.47250177
10PTK62.46110797
11LMTK22.46057469
12MAP3K102.43949236
13PRPF4B2.32960654
14EPHA22.16654150
15NME11.96464463
16MAP3K21.86541271
17TBK11.75287072
18STK101.74032782
19CDC42BPA1.73886286
20MAP2K21.72762644
21EPHB11.68632493
22TAOK31.68424793
23TAOK21.53486438
24RIPK41.52421421
25TYK21.51483135
26BMX1.48077459
27MATK1.38788327
28IRAK31.37917620
29NUAK11.33347636
30MET1.24832072
31LATS11.23469264
32EPHB21.22347414
33CDK121.22014470
34FGFR41.21776806
35TAOK11.18639160
36SIK11.16434463
37TRIB31.14669525
38TESK21.11031614
39NME21.10991557
40PTK21.03216460
41GRK71.01858240
42PAK40.96705651
43KIT0.92881127
44TESK10.92023908
45KSR20.91590575
46ERBB20.91430021
47MAP3K30.91333191
48MAP3K110.89762139
49LRRK20.88095277
50CSK0.87805555
51DDR20.87798791
52MAP3K70.83570933
53MAP4K10.82895228
54PKN20.82545423
55BLK0.79884606
56SCYL20.79689969
57MAP3K130.76836428
58PRKAA20.76526044
59MAP3K80.76086973
60SMG10.75886017
61IKBKE0.75855128
62PRKD20.74874238
63IKBKB0.74620472
64CAMK1D0.73860020
65FER0.73338862
66MAP3K10.73054069
67JAK10.72098442
68MOS0.69543961
69IRAK10.66418141
70MAP3K140.66271882
71JAK20.65663085
72SYK0.64021611
73PRKCI0.62603389
74MAPK110.62456965
75PBK0.61508548
76LYN0.61114388
77CDK60.57914376
78STK30.57478097
79FGFR30.56837067
80RPS6KA20.56644646
81HCK0.56623190
82MAP2K10.54043862
83PDPK10.54004919
84TGFBR20.53524636
85BTK0.52976477
86EPHA30.52942376
87MAPK70.52554401
88ICK0.51993939
89LCK0.51950864
90PDK20.51010932
91BMPR20.49614149
92MAP3K60.48736185
93MAP3K50.47567059
94FGR0.47346201
95CSF1R0.47201994
96MAP2K60.46271505
97DYRK1B0.45946786
98ERBB40.45016302
99RPS6KL10.43985482
100RPS6KC10.43985482
101JAK30.42045239
102TTN0.41735445
103PDGFRA0.40952055
104CHUK0.40472687
105PRKCD0.40206971
106PIK3CA0.40168016
107FES0.39951144
108MAP2K30.39730790
109EGFR0.39079669
110GSK3A0.38285549
111SRC0.37990589
112CAMKK20.37846317
113IRAK20.36616264
114MAPKAPK20.36602633
115PIM20.35707607
116ITK0.35434724
117SIK30.35175327
118INSRR0.33834843
119FYN0.32055704
120PDGFRB0.31660884
121ZAP700.31489614
122PRKAA10.31017586
123PDK10.30574459
124MYLK0.30242974
125BCKDK0.29590362
126PRKACG0.29571104
127IRAK40.28954900
128ABL20.28551316
129SGK30.28010353
130ABL10.27863461
131NEK90.27666175

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.30755020
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.44052129
3Vitamin digestion and absorption_Homo sapiens_hsa049773.64054111
4Caffeine metabolism_Homo sapiens_hsa002323.55155134
5* Renin-angiotensin system_Homo sapiens_hsa046143.37001040
6Mineral absorption_Homo sapiens_hsa049783.20915123
7Galactose metabolism_Homo sapiens_hsa000522.74550963
8Starch and sucrose metabolism_Homo sapiens_hsa005002.72373830
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51003883
10Protein digestion and absorption_Homo sapiens_hsa049742.21947233
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18250197
12Bile secretion_Homo sapiens_hsa049762.11466416
13Histidine metabolism_Homo sapiens_hsa003402.04023764
14Folate biosynthesis_Homo sapiens_hsa007901.80562775
15PPAR signaling pathway_Homo sapiens_hsa033201.80247774
16Tryptophan metabolism_Homo sapiens_hsa003801.78975741
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.76722959
18Arginine biosynthesis_Homo sapiens_hsa002201.71246705
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55369476
20Nitrogen metabolism_Homo sapiens_hsa009101.54706212
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52204306
22Sulfur metabolism_Homo sapiens_hsa009201.51146879
23Asthma_Homo sapiens_hsa053101.48953618
24Allograft rejection_Homo sapiens_hsa053301.44432013
25Fructose and mannose metabolism_Homo sapiens_hsa000511.44186772
26Fatty acid degradation_Homo sapiens_hsa000711.34155671
27Glycerolipid metabolism_Homo sapiens_hsa005611.33441126
28Graft-versus-host disease_Homo sapiens_hsa053321.30270583
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25226265
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.24086416
31Sphingolipid metabolism_Homo sapiens_hsa006001.22347212
32Autoimmune thyroid disease_Homo sapiens_hsa053201.17755930
33Rheumatoid arthritis_Homo sapiens_hsa053231.12423569
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09146230
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06256240
36ABC transporters_Homo sapiens_hsa020101.02773965
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.00754282
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.99583973
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97836477
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96156130
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95884107
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.95494077
43Arginine and proline metabolism_Homo sapiens_hsa003300.90949990
44Malaria_Homo sapiens_hsa051440.90139098
45beta-Alanine metabolism_Homo sapiens_hsa004100.88680737
46Staphylococcus aureus infection_Homo sapiens_hsa051500.87829092
47Type I diabetes mellitus_Homo sapiens_hsa049400.87491950
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85745590
49Antigen processing and presentation_Homo sapiens_hsa046120.83706843
50Phagosome_Homo sapiens_hsa041450.81085539
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78798433
52Peroxisome_Homo sapiens_hsa041460.78218815
53Chemical carcinogenesis_Homo sapiens_hsa052040.76807899
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76253001
55Prion diseases_Homo sapiens_hsa050200.76239792
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75367493
57Retinol metabolism_Homo sapiens_hsa008300.75296671
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75147229
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75124550
60Complement and coagulation cascades_Homo sapiens_hsa046100.72395185
61Chemokine signaling pathway_Homo sapiens_hsa040620.71826900
62Steroid biosynthesis_Homo sapiens_hsa001000.70573602
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69091414
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68668453
65* Hematopoietic cell lineage_Homo sapiens_hsa046400.67122983
66Viral myocarditis_Homo sapiens_hsa054160.66141860
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65008422
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.63122925
69Bladder cancer_Homo sapiens_hsa052190.61841759
70Fatty acid metabolism_Homo sapiens_hsa012120.61686018
71Pyruvate metabolism_Homo sapiens_hsa006200.60926507
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.60634093
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57806589
74Carbon metabolism_Homo sapiens_hsa012000.57513232
75Lysosome_Homo sapiens_hsa041420.57103991
76B cell receptor signaling pathway_Homo sapiens_hsa046620.56000700
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53906106
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53182059
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.51661794
80Type II diabetes mellitus_Homo sapiens_hsa049300.51229220
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50049886
82Lysine degradation_Homo sapiens_hsa003100.47101859
83Shigellosis_Homo sapiens_hsa051310.46936826
84* Glutathione metabolism_Homo sapiens_hsa004800.46805152
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45237856
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45223856
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45127080
88Pentose phosphate pathway_Homo sapiens_hsa000300.45046412
89Selenocompound metabolism_Homo sapiens_hsa004500.44827220
90Butanoate metabolism_Homo sapiens_hsa006500.44395765
91Leishmaniasis_Homo sapiens_hsa051400.43850730
92Acute myeloid leukemia_Homo sapiens_hsa052210.42670673
93Hepatitis C_Homo sapiens_hsa051600.42093387
94Ether lipid metabolism_Homo sapiens_hsa005650.41998850
95Other glycan degradation_Homo sapiens_hsa005110.40879641
96Pertussis_Homo sapiens_hsa051330.40656520
97Thyroid hormone synthesis_Homo sapiens_hsa049180.38287305
98African trypanosomiasis_Homo sapiens_hsa051430.37721342
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37323650
100Herpes simplex infection_Homo sapiens_hsa051680.36990435
101Salmonella infection_Homo sapiens_hsa051320.36637695
102Insulin resistance_Homo sapiens_hsa049310.36564984
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35935388
104Tuberculosis_Homo sapiens_hsa051520.35561350
105Hepatitis B_Homo sapiens_hsa051610.34576168
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33113761
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.32911843
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.32831711
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30605406
110Phenylalanine metabolism_Homo sapiens_hsa003600.30318632
111Fatty acid biosynthesis_Homo sapiens_hsa000610.29374722
112Pancreatic secretion_Homo sapiens_hsa049720.29017726
113Legionellosis_Homo sapiens_hsa051340.27314640
114Biosynthesis of amino acids_Homo sapiens_hsa012300.26651290
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25755488
116Toxoplasmosis_Homo sapiens_hsa051450.23280054
117Influenza A_Homo sapiens_hsa051640.23161698
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.22903979
119Amoebiasis_Homo sapiens_hsa051460.21886240
120Adherens junction_Homo sapiens_hsa045200.21536386
121Linoleic acid metabolism_Homo sapiens_hsa005910.21278874
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21238792
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19568135
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.19482611
125Osteoclast differentiation_Homo sapiens_hsa043800.19148027
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19095049
127Apoptosis_Homo sapiens_hsa042100.17548835
128TNF signaling pathway_Homo sapiens_hsa046680.17168978
129Arachidonic acid metabolism_Homo sapiens_hsa005900.17151899
130Propanoate metabolism_Homo sapiens_hsa006400.15651793

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