ANTXR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration involved in heart development (GO:0060973)5.41159597
2collagen fibril organization (GO:0030199)5.13191564
3bone trabecula formation (GO:0060346)5.04902353
4protein heterotrimerization (GO:0070208)4.91976873
5sequestering of extracellular ligand from receptor (GO:0035581)4.62524774
6chondrocyte proliferation (GO:0035988)4.44891111
7mesenchymal-epithelial cell signaling (GO:0060638)4.42754136
8lateral sprouting from an epithelium (GO:0060601)4.24287256
9skin morphogenesis (GO:0043589)3.86868902
10enteric nervous system development (GO:0048484)3.86102503
11regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.82245331
12collagen catabolic process (GO:0030574)3.81695901
13collagen metabolic process (GO:0032963)3.80554080
14extracellular fibril organization (GO:0043206)3.73630265
15craniofacial suture morphogenesis (GO:0097094)3.66170591
16regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.63485458
17multicellular organismal macromolecule metabolic process (GO:0044259)3.59208924
18paraxial mesoderm development (GO:0048339)3.58496483
19endodermal cell differentiation (GO:0035987)3.56937923
20multicellular organismal catabolic process (GO:0044243)3.50276414
21chondrocyte development (GO:0002063)3.50008026
22dermatan sulfate biosynthetic process (GO:0030208)3.44316697
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.42177270
24axon extension involved in axon guidance (GO:0048846)3.42177270
25extracellular matrix assembly (GO:0085029)3.37129740
26multicellular organismal metabolic process (GO:0044236)3.36105918
27ganglion development (GO:0061548)3.33245009
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31630477
29limb bud formation (GO:0060174)3.30937028
30negative regulation of chondrocyte differentiation (GO:0032331)3.30760919
31negative regulation of catenin import into nucleus (GO:0035414)3.30519213
32hemidesmosome assembly (GO:0031581)3.29761394
33planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28831623
34myelination in peripheral nervous system (GO:0022011)3.27950158
35peripheral nervous system axon ensheathment (GO:0032292)3.27950158
36metanephric mesenchyme development (GO:0072075)3.27874581
37extracellular matrix disassembly (GO:0022617)3.27546906
38prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.25961851
39regulation of cardioblast proliferation (GO:0003264)3.19887038
40regulation of secondary heart field cardioblast proliferation (GO:0003266)3.19887038
41positive regulation of osteoblast proliferation (GO:0033690)3.18100232
42desmosome organization (GO:0002934)3.12953932
43endocardial cushion morphogenesis (GO:0003203)3.12112887
44branching involved in salivary gland morphogenesis (GO:0060445)3.11327606
45embryonic cranial skeleton morphogenesis (GO:0048701)3.10406032
46dermatan sulfate metabolic process (GO:0030205)3.09280254
47regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07558582
48peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.04760428
49kidney mesenchyme development (GO:0072074)3.04018968
50cochlea morphogenesis (GO:0090103)3.03435759
51fibril organization (GO:0097435)3.02652844
52midgut development (GO:0007494)3.02529492
53mesenchyme morphogenesis (GO:0072132)3.02264065
54vascular endothelial growth factor signaling pathway (GO:0038084)3.01692818
55outer ear morphogenesis (GO:0042473)3.01105516
56regulation of heart morphogenesis (GO:2000826)2.99441197
57positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.98824794
58extracellular regulation of signal transduction (GO:1900115)2.98253819
59extracellular negative regulation of signal transduction (GO:1900116)2.98253819
60positive regulation of mesenchymal cell proliferation (GO:0002053)2.98017327
61glial cell migration (GO:0008347)2.97428506
62keratinocyte proliferation (GO:0043616)2.95837828
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94916875
64regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.94089423
65smooth muscle tissue development (GO:0048745)2.90982739
66blood vessel maturation (GO:0001955)2.89476461
67glomerular basement membrane development (GO:0032836)2.89013220
68pericardium development (GO:0060039)2.88488528
69cell migration involved in sprouting angiogenesis (GO:0002042)2.88456673
70negative regulation of embryonic development (GO:0045992)2.85613187
71glomerular filtration (GO:0003094)2.85445822
72mesenchymal cell proliferation (GO:0010463)2.84909363
73cranial suture morphogenesis (GO:0060363)2.83953430
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.83720107
75regulation of mesenchymal cell proliferation (GO:0010464)2.81911603
76basement membrane organization (GO:0071711)2.81542430
77radial glial cell differentiation (GO:0060019)2.79222274
78muscle cell migration (GO:0014812)2.78650264
79endothelial cell morphogenesis (GO:0001886)2.78273358
80establishment of tissue polarity (GO:0007164)2.77937740
81establishment of planar polarity (GO:0001736)2.77937740
82extracellular matrix organization (GO:0030198)2.77779300
83cell proliferation involved in metanephros development (GO:0072203)2.77051912
84adhesion of symbiont to host cell (GO:0044650)2.76817096
85virion attachment to host cell (GO:0019062)2.76817096
86extracellular structure organization (GO:0043062)2.76618644
87retina vasculature morphogenesis in camera-type eye (GO:0061299)2.76366561
88branch elongation of an epithelium (GO:0060602)2.75545123
89axis elongation (GO:0003401)2.74892745
90regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.72091539
91type B pancreatic cell proliferation (GO:0044342)2.71605517
92negative regulation of leukocyte chemotaxis (GO:0002689)2.69936108
93middle ear morphogenesis (GO:0042474)2.69792175
94renal filtration (GO:0097205)2.68903554
95cell proliferation involved in kidney development (GO:0072111)2.68755911
96regulation of axon extension involved in axon guidance (GO:0048841)2.68339660
97negative regulation of cartilage development (GO:0061037)2.67566949
98positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67041650
99regulation of organ formation (GO:0003156)2.66521720
100organ induction (GO:0001759)2.65866638
101tooth mineralization (GO:0034505)2.65010969
102atrioventricular valve morphogenesis (GO:0003181)2.64820032
103substrate-dependent cell migration (GO:0006929)2.64444328
104negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.63632590
105mesodermal cell differentiation (GO:0048333)2.62860846
106cellular response to vitamin (GO:0071295)2.62852342
107protein localization to cell surface (GO:0034394)2.61621671
108Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.61190307
109negative regulation of BMP signaling pathway (GO:0030514)2.60802762
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60606131
111convergent extension (GO:0060026)2.60413588
112cellular response to vitamin D (GO:0071305)2.60178972
113regulation of chondrocyte differentiation (GO:0032330)2.59108382
114protein retention in ER lumen (GO:0006621)2.57836152
115cell-substrate junction assembly (GO:0007044)2.57107964
116negative regulation of axon extension involved in axon guidance (GO:0048843)2.56837356
117camera-type eye morphogenesis (GO:0048593)2.55663543
118branching involved in prostate gland morphogenesis (GO:0060442)2.55408225
119cell adhesion mediated by integrin (GO:0033627)2.55405411
120dopaminergic neuron differentiation (GO:0071542)2.55324558
121keratan sulfate catabolic process (GO:0042340)2.55150111
122artery morphogenesis (GO:0048844)2.54680961
123regulation of catenin import into nucleus (GO:0035412)2.54185603
124adherens junction assembly (GO:0034333)2.53561598
125maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52913868
126face morphogenesis (GO:0060325)2.51753192
127regulation of osteoblast proliferation (GO:0033688)2.51618906
128positive regulation of cartilage development (GO:0061036)2.51201991
129regulation of establishment of planar polarity (GO:0090175)2.51182426
130negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.51046445
131adhesion of symbiont to host (GO:0044406)2.50144970
132trabecula formation (GO:0060343)2.48199107
133non-canonical Wnt signaling pathway (GO:0035567)2.48180967
134wound healing, spreading of epidermal cells (GO:0035313)2.47513712
135regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.47084507
136regulation of cartilage development (GO:0061035)2.46864929
137endocardial cushion development (GO:0003197)2.46845109
138hippo signaling (GO:0035329)2.45994479
139cardiac epithelial to mesenchymal transition (GO:0060317)2.44695712
140regulation of non-canonical Wnt signaling pathway (GO:2000050)2.44350615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.06368337
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.89826704
3EED_16625203_ChIP-ChIP_MESCs_Mouse2.68290731
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56662051
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45090891
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45087400
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45087400
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43876101
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35554204
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31290660
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29766422
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28524895
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27168673
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25177230
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.23599885
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20818606
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13347457
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.11238777
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08596870
20GBX2_23144817_ChIP-Seq_PC3_Human2.08289994
21EZH2_22144423_ChIP-Seq_EOC_Human2.03063227
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01371363
23* WT1_19549856_ChIP-ChIP_CCG9911_Human2.01228836
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.94575763
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93194573
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91502283
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88677084
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87903198
29AR_21572438_ChIP-Seq_LNCaP_Human1.83899442
30* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.83250294
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.83187880
32CJUN_26792858_Chip-Seq_BT549_Human1.82681634
33* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82031634
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.80580461
35TP53_18474530_ChIP-ChIP_U2OS_Human1.75932246
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73589680
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72770498
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67596338
39TP53_16413492_ChIP-PET_HCT116_Human1.65860225
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65154734
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61039492
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61039492
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.57647339
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57569561
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55946790
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.55525554
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.54912804
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52887450
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.52142693
50GATA1_22025678_ChIP-Seq_K562_Human1.48252461
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46625170
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.43465776
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.41760751
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39887185
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.37610273
56* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.36578468
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36578363
58DROSHA_22980978_ChIP-Seq_HELA_Human1.35576653
59CLOCK_20551151_ChIP-Seq_293T_Human1.34709949
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34450163
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32894057
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29672657
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29495156
64SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.29170489
65AHR_22903824_ChIP-Seq_MCF-7_Human1.29049689
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27867326
67CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27742736
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24938071
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.24247563
70* ISL1_27105846_Chip-Seq_CPCs_Mouse1.22724290
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21741945
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.21074093
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.21074093
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.20919470
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18951045
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.18671863
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.17523011
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17082767
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15371638
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14781941
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.14667588
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14612608
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.13266505
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12977312
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12852199
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12014988
87* BRD4_25478319_ChIP-Seq_HGPS_Human1.11245443
88* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09804972
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.08406936
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07298951
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07298951
92SMAD4_21799915_ChIP-Seq_A2780_Human1.06487963
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05852136
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05801477
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05497599
96AR_21909140_ChIP-Seq_LNCAP_Human1.05455369
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05419260
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05181828
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04884883
100* SOX2_20726797_ChIP-Seq_SW620_Human1.04140091
101* P300_19829295_ChIP-Seq_ESCs_Human1.04040195
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.03878805
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03136978
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03089382
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02759551
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02561114
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.02308619
108MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01424466
109BCAT_22108803_ChIP-Seq_LS180_Human1.00703014
110RXR_22108803_ChIP-Seq_LS180_Human1.00576229
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00573039
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99007301
113* TP53_23651856_ChIP-Seq_MEFs_Mouse0.98999919
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98998922
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98735427
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.97236654
117FUS_26573619_Chip-Seq_HEK293_Human0.97191907
118TCF4_18268006_ChIP-ChIP_LS174T_Human0.97116152
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96316184
120NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95598112
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.94901600
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94242082
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93806711
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93753391
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92986082
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.92065921
127* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91460683
128TP53_22127205_ChIP-Seq_IMR90_Human0.91452197
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90700420
130* SA1_22415368_ChIP-Seq_MEFs_Mouse0.87793384
131* TP63_23658742_ChIP-Seq_EP156T_Human0.87789060
132FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86001576
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85791541
134KLF5_25053715_ChIP-Seq_YYC3_Human0.84906820
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83851390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.89811897
2MP0005275_abnormal_skin_tensile5.59380242
3MP0005503_abnormal_tendon_morphology5.13848764
4MP0004272_abnormal_basement_membrane3.12543854
5MP0001958_emphysema2.91190160
6MP0003279_aneurysm2.69101714
7MP0009250_abnormal_appendicular_skeleto2.55856996
8MP0005623_abnormal_meninges_morphology2.34317404
9MP0005508_abnormal_skeleton_morphology2.25940624
10MP0002060_abnormal_skin_morphology2.16899316
11MP0003705_abnormal_hypodermis_morpholog2.11795130
12MP0010030_abnormal_orbit_morphology2.11515050
13MP0009384_cardiac_valve_regurgitation2.02193974
14MP0002295_abnormal_pulmonary_circulatio1.95620646
15MP0003385_abnormal_body_wall1.93000979
16MP0002108_abnormal_muscle_morphology1.91999050
17MP0005257_abnormal_intraocular_pressure1.88565422
18MP0002282_abnormal_trachea_morphology1.72745292
19MP0001299_abnormal_eye_distance/1.68559540
20MP0005171_absent_coat_pigmentation1.65826991
21MP0000762_abnormal_tongue_morphology1.62540687
22MP0004134_abnormal_chest_morphology1.59978844
23MP0010352_gastrointestinal_tract_polyps1.59630140
24MP0001542_abnormal_bone_strength1.57473593
25MP0003950_abnormal_plasma_membrane1.56832445
26MP0002249_abnormal_larynx_morphology1.52686841
27MP0002896_abnormal_bone_mineralization1.47402650
28MP0003942_abnormal_urinary_system1.47214406
29MP0000049_abnormal_middle_ear1.47071408
30MP0000534_abnormal_ureter_morphology1.46243614
31MP0010386_abnormal_urinary_bladder1.45439755
32MP0000383_abnormal_hair_follicle1.43458742
33MP0000566_synostosis1.42781760
34MP0006054_spinal_hemorrhage1.41372601
35MP0003755_abnormal_palate_morphology1.41211164
36MP0010678_abnormal_skin_adnexa1.40131126
37MP0001243_abnormal_dermal_layer1.38078987
38MP0010368_abnormal_lymphatic_system1.36642946
39MP0000647_abnormal_sebaceous_gland1.35663096
40MP0009379_abnormal_foot_pigmentation1.35648344
41MP0003937_abnormal_limbs/digits/tail_de1.33168508
42MP0000428_abnormal_craniofacial_morphol1.33058333
43MP0003941_abnormal_skin_development1.32241361
44MP0000462_abnormal_digestive_system1.31445124
45MP0000163_abnormal_cartilage_morphology1.30471839
46MP0002938_white_spotting1.27566041
47MP0004858_abnormal_nervous_system1.25929492
48MP0000537_abnormal_urethra_morphology1.25775459
49MP0002233_abnormal_nose_morphology1.23993822
50MP0005197_abnormal_uvea_morphology1.23846073
51MP0000733_abnormal_muscle_development1.22207576
52* MP0002115_abnormal_skeleton_extremities1.21103427
53MP0002932_abnormal_joint_morphology1.20434604
54MP0000751_myopathy1.19713641
55MP0000013_abnormal_adipose_tissue1.18779980
56MP0003566_abnormal_cell_adhesion1.18447728
57MP0002638_abnormal_pupillary_reflex1.17047394
58MP0009053_abnormal_anal_canal1.17042469
59MP0000579_abnormal_nail_morphology1.16063781
60* MP0003935_abnormal_craniofacial_develop1.14756320
61* MP0002116_abnormal_craniofacial_bone1.12985520
62MP0002796_impaired_skin_barrier1.12761378
63MP0001346_abnormal_lacrimal_gland1.11353804
64MP0005023_abnormal_wound_healing1.09086697
65MP0002751_abnormal_autonomic_nervous1.07356261
66MP0001177_atelectasis1.07245189
67MP0003115_abnormal_respiratory_system1.06472165
68MP0001849_ear_inflammation1.05606907
69* MP0000432_abnormal_head_morphology1.05473678
70MP0002109_abnormal_limb_morphology1.01892731
71MP0003091_abnormal_cell_migration1.01493368
72MP0005390_skeleton_phenotype1.01332044
73MP0010771_integument_phenotype1.00948530
74MP0000759_abnormal_skeletal_muscle1.00648179
75MP0002177_abnormal_outer_ear1.00583788
76MP0000749_muscle_degeneration0.98296199
77MP0000767_abnormal_smooth_muscle0.97889459
78MP0002113_abnormal_skeleton_development0.95741675
79MP0001879_abnormal_lymphatic_vessel0.95703860
80MP0003045_fibrosis0.95266966
81MP0001340_abnormal_eyelid_morphology0.93292705
82MP0006138_congestive_heart_failure0.92631023
83MP0002877_abnormal_melanocyte_morpholog0.92047719
84MP0005388_respiratory_system_phenotype0.90854761
85MP0002133_abnormal_respiratory_system0.90854761
86MP0002998_abnormal_bone_remodeling0.89940757
87MP0002234_abnormal_pharynx_morphology0.88974092
88MP0005367_renal/urinary_system_phenotyp0.87382812
89MP0000516_abnormal_urinary_system0.87382812
90MP0000681_abnormal_thyroid_gland0.86994702
91MP0005248_abnormal_Harderian_gland0.84692283
92MP0002089_abnormal_postnatal_growth/wei0.84150230
93MP0000538_abnormal_urinary_bladder0.83860434
94MP0003938_abnormal_ear_development0.83558123
95MP0002697_abnormal_eye_size0.83311346
96MP0002128_abnormal_blood_circulation0.82821679
97MP0004883_abnormal_blood_vessel0.81654442
98* MP0002168_other_aberrant_phenotype0.78591731
99MP0003283_abnormal_digestive_organ0.78431603
100MP0000750_abnormal_muscle_regeneration0.77225798
101MP0004084_abnormal_cardiac_muscle0.76983381
102MP0005187_abnormal_penis_morphology0.76975523
103MP0002933_joint_inflammation0.76439265
104MP0009780_abnormal_chondrocyte_physiolo0.76209057
105MP0000467_abnormal_esophagus_morphology0.75682514
106MP0005369_muscle_phenotype0.75643607
107MP0005193_abnormal_anterior_eye0.75170848
108MP0005076_abnormal_cell_differentiation0.74796353
109* MP0002114_abnormal_axial_skeleton0.73880837
110MP0005164_abnormal_response_to0.73248660
111MP0001614_abnormal_blood_vessel0.72577441
112MP0003453_abnormal_keratinocyte_physiol0.71634890
113MP0001348_abnormal_lacrimal_gland0.70578037
114MP0001270_distended_abdomen0.69701040
115MP0002098_abnormal_vibrissa_morphology0.69191439
116MP0000377_abnormal_hair_follicle0.68904194
117MP0005409_darkened_coat_color0.68653427
118MP0004233_abnormal_muscle_weight0.67149024
119MP0001915_intracranial_hemorrhage0.66753671
120MP0005595_abnormal_vascular_smooth0.66601542
121MP0002925_abnormal_cardiovascular_devel0.66365680
122MP0010234_abnormal_vibrissa_follicle0.66196019
123MP0002254_reproductive_system_inflammat0.66141794
124MP0001175_abnormal_lung_morphology0.65684065
125MP0003136_yellow_coat_color0.65608577
126MP0003122_maternal_imprinting0.65493691
127MP0001661_extended_life_span0.63728482
128MP0002092_abnormal_eye_morphology0.63700085
129MP0004087_abnormal_muscle_fiber0.60989418
130MP0000003_abnormal_adipose_tissue0.60543038
131MP0002269_muscular_atrophy0.60096892
132MP0002111_abnormal_tail_morphology0.56972231

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.41338847
2Protrusio acetabuli (HP:0003179)6.38875813
3Broad metatarsal (HP:0001783)4.98542965
4Atrophic scars (HP:0001075)4.81103329
5Shallow orbits (HP:0000586)4.65733439
6Ankle contracture (HP:0006466)4.42489586
7Aortic dissection (HP:0002647)4.22085085
8Soft skin (HP:0000977)3.81214093
9Follicular hyperkeratosis (HP:0007502)3.73791123
10Abnormality of dentin (HP:0010299)3.56903115
11Fragile skin (HP:0001030)3.42687344
12Peritonitis (HP:0002586)3.38391076
13Bladder diverticulum (HP:0000015)3.37788953
14Neonatal short-limb short stature (HP:0008921)3.25727491
15Type 1 muscle fiber predominance (HP:0003803)3.23159477
16Bell-shaped thorax (HP:0001591)3.02434208
17Spinal rigidity (HP:0003306)3.01435181
18Wormian bones (HP:0002645)2.99598682
19Aplasia involving bones of the upper limbs (HP:0009823)2.98008724
20Aplasia of the phalanges of the hand (HP:0009802)2.98008724
21Aplasia involving bones of the extremities (HP:0009825)2.98008724
22Cervical subluxation (HP:0003308)2.87740354
23Cerebral aneurysm (HP:0004944)2.85339253
24Mild short stature (HP:0003502)2.80597694
25Slender build (HP:0001533)2.79645650
26Aortic aneurysm (HP:0004942)2.75442735
27Mitral valve prolapse (HP:0001634)2.75046905
28Coronal craniosynostosis (HP:0004440)2.74805238
29Absent frontal sinuses (HP:0002688)2.67609621
30Blue sclerae (HP:0000592)2.65538655
31Dilatation of the ascending aorta (HP:0005111)2.64639384
32* Hyperextensible skin (HP:0000974)2.54056321
33Vascular tortuosity (HP:0004948)2.53206335
34Abnormality of the parietal bone (HP:0002696)2.50821912
35Buphthalmos (HP:0000557)2.50752084
36Infantile muscular hypotonia (HP:0008947)2.50327537
37Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50293750
38Short 4th metacarpal (HP:0010044)2.50293750
39Deviation of the hallux (HP:0010051)2.46085313
40Genu recurvatum (HP:0002816)2.43134322
41Ulnar bowing (HP:0003031)2.39894865
42Increased variability in muscle fiber diameter (HP:0003557)2.39598662
43Aortic regurgitation (HP:0001659)2.38855743
44Wrist flexion contracture (HP:0001239)2.38537350
45Short hallux (HP:0010109)2.34135037
46Arterial tortuosity (HP:0005116)2.33801312
47Hallux valgus (HP:0001822)2.30825468
48Breech presentation (HP:0001623)2.30823217
49* Wide anterior fontanel (HP:0000260)2.30713860
50Spondylolisthesis (HP:0003302)2.30044359
51Osteolytic defects of the hand bones (HP:0009699)2.24747713
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.24747713
53Increased connective tissue (HP:0009025)2.24006559
54Abnormality of the acetabulum (HP:0003170)2.22363602
55Joint laxity (HP:0001388)2.19262125
56Broad ribs (HP:0000885)2.17621432
57Aneurysm (HP:0002617)2.16352125
58Overgrowth (HP:0001548)2.15664204
59Bronchomalacia (HP:0002780)2.14282641
60Pulmonary artery stenosis (HP:0004415)2.13730309
61Mesomelia (HP:0003027)2.13043487
62Morphological abnormality of the middle ear (HP:0008609)2.12648799
63Calcaneovalgus deformity (HP:0001848)2.11449817
64Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.10893018
65Abnormality of the 4th metacarpal (HP:0010012)2.10329406
66Mildly elevated creatine phosphokinase (HP:0008180)2.10181255
67Hypoplasia of the iris (HP:0007676)2.10015040
68Bowel diverticulosis (HP:0005222)2.07496799
69Alacrima (HP:0000522)2.06252228
70Femoral bowing (HP:0002980)2.06108765
71Abnormal delivery (HP:0001787)2.05274777
72Microglossia (HP:0000171)2.05033712
73Aplasia/Hypoplasia of the hallux (HP:0008362)2.03286314
74Elbow flexion contracture (HP:0002987)2.01881482
75Round ear (HP:0100830)2.00327964
76Ectopia lentis (HP:0001083)1.99603392
77Abnormality of the middle phalanges of the toes (HP:0010183)1.99157162
78Milia (HP:0001056)1.98934760
79Deformed tarsal bones (HP:0008119)1.98437757
80Hypoventilation (HP:0002791)1.97908792
81Turricephaly (HP:0000262)1.97902004
82Venous insufficiency (HP:0005293)1.97440275
83Aortic valve stenosis (HP:0001650)1.96958779
84Narrow nasal bridge (HP:0000446)1.96485023
85Disproportionate tall stature (HP:0001519)1.96312646
86Nasolacrimal duct obstruction (HP:0000579)1.96282613
87Abnormality of skeletal muscle fiber size (HP:0012084)1.95812960
88Biconcave vertebral bodies (HP:0004586)1.95662023
89Tibial bowing (HP:0002982)1.95073274
90Limited hip movement (HP:0008800)1.94604688
91Synostosis involving the elbow (HP:0003938)1.93085392
92Humeroradial synostosis (HP:0003041)1.93085392
93Osteoarthritis (HP:0002758)1.91530267
94Thin ribs (HP:0000883)1.88006866
95* Delayed cranial suture closure (HP:0000270)1.87362517
96Partial duplication of the phalanx of hand (HP:0009999)1.87335814
97Renal duplication (HP:0000075)1.85955743
98Delayed closure of the anterior fontanelle (HP:0001476)1.85692573
99Tarsal synostosis (HP:0008368)1.85346090
100Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.83872867
101Persistence of primary teeth (HP:0006335)1.83660453
102Onycholysis (HP:0001806)1.83558867
103Abnormality of the 2nd finger (HP:0004100)1.82828439
104Abnormality of the phalanges of the hallux (HP:0010057)1.82291213
105Flat cornea (HP:0007720)1.82134507
106Inguinal hernia (HP:0000023)1.82080518
107Natal tooth (HP:0000695)1.82012130
108Scapular winging (HP:0003691)1.81346682
109Right ventricular cardiomyopathy (HP:0011663)1.81018645
110Renovascular hypertension (HP:0100817)1.77573918
111Mitral stenosis (HP:0001718)1.77353382
112Abnormality of the nasolacrimal system (HP:0000614)1.77265793
113Broad long bones (HP:0005622)1.77095949
114Bowed forearm bones (HP:0003956)1.77025224
115Bowing of the arm (HP:0006488)1.77025224
116Cupped ribs (HP:0000887)1.76129456
117Camptodactyly of toe (HP:0001836)1.75864889
118Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74891784
119Long toe (HP:0010511)1.73368992
120* Venous abnormality (HP:0002624)1.73170310
121Broad toe (HP:0001837)1.73143040
122Mitral regurgitation (HP:0001653)1.72507913
123Knee flexion contracture (HP:0006380)1.72493694
124Vertebral compression fractures (HP:0002953)1.70138165
125Hypoplastic ischia (HP:0003175)1.70106321
126Coxa vara (HP:0002812)1.67513114
127Syringomyelia (HP:0003396)1.66791885
128Spinal cord lesions (HP:0100561)1.66791885
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.62834433
130Short nail (HP:0001799)1.62076433
131Flexion contracture of toe (HP:0005830)1.61970227
132Joint contractures involving the joints of the feet (HP:0100492)1.61970227
133* Protruding ear (HP:0000411)1.61927512
134Abnormality of the calcaneus (HP:0008364)1.61277835
135Abnormality of the frontal sinuses (HP:0002687)1.61201218

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.54318298
2LATS13.83538300
3FGFR23.40861047
4PDGFRA3.31623524
5EPHB22.85090898
6LATS22.45834624
7FER2.37970360
8TTN2.34267723
9EPHA32.17340747
10NEK92.10527185
11SIK12.08635707
12ICK2.07173559
13EPHB11.93869347
14NTRK11.81380985
15STK391.81209035
16PTK2B1.71829179
17MAP3K101.67636662
18AKT31.61000577
19ROCK21.56215533
20PDGFRB1.54653103
21MET1.53640320
22MAPKAPK51.51396207
23RIPK11.50881944
24PAK31.48172569
25PAK21.48035935
26PLK21.47778318
27DMPK1.42248601
28TGFBR21.41416288
29FGFR11.41041310
30TRPM71.40165268
31ROCK11.33004291
32PTK21.28581494
33BCR1.22735808
34BMX1.21969379
35EPHA41.18423248
36STK31.17387952
37CASK1.13589454
38FGFR41.10935414
39LIMK11.07772199
40PBK1.07735637
41FGR1.06487342
42TESK11.04971187
43CDK121.03345951
44MYLK1.02948632
45STK381.02865502
46WNK11.01629740
47ADRBK10.97618298
48MELK0.93137868
49MUSK0.91712088
50FLT30.90145917
51PRKCE0.89656362
52LRRK20.89076178
53MAP3K60.89074337
54PRKD30.87870559
55ERBB30.86404522
56PIK3CA0.86247531
57NTRK20.85010334
58TYRO30.83738170
59CAMK1G0.83033499
60EEF2K0.82843855
61MAPK130.81825219
62ERN10.79830119
63CSNK1A1L0.77605227
64CSNK1G10.73784504
65TGFBR10.73314660
66PKN10.73224499
67CDK80.73131995
68PTK60.73095853
69CAMK2B0.70745039
70MAPK150.69993550
71MOS0.69142168
72CAMK2G0.68708855
73TIE10.68682592
74GSK3A0.67851667
75NUAK10.65273048
76MST40.65176143
77ABL20.64609230
78UHMK10.64439546
79PRKD10.64347020
80MAP2K10.64035200
81RET0.63427674
82BRD40.62586028
83PRKD20.62338397
84TRIB30.62019445
85CDK60.61548445
86INSR0.60670181
87FRK0.60558119
88NME10.60458745
89PRKCH0.58328602
90CDC42BPA0.58251883
91PNCK0.57589942
92MAPK70.56954907
93STK38L0.56790348
94RPS6KA20.56456398
95ILK0.56437461
96MAP3K70.55729510
97OXSR10.54917142
98ERBB40.54739862
99MST1R0.54692275
100CAMK2A0.54562880
101DAPK30.53820758
102PIK3CG0.52763141
103SMG10.51693795
104SRC0.49945878
105CAMK2D0.49672836
106ERBB20.49299200
107MAP3K20.48721091
108PAK40.48548368
109MARK20.48352475
110WNK40.47835602
111TNIK0.47513903
112PKN20.47214464
113MTOR0.46019273
114NLK0.45992472
115SCYL20.45239304
116DYRK20.45200331
117GRK50.45189853
118DYRK1B0.44911379
119FYN0.42287849
120LMTK20.41209319
121CLK10.41200694
122MARK10.40973096
123PHKG10.40757678
124PHKG20.40757678
125CSNK1G30.40623728
126CDK70.38649713
127CAMK1D0.36823885
128ABL10.36000680
129CDK140.34635984
130CSNK1G20.34469444
131INSRR0.34349231
132PAK60.33472313
133FGFR30.32027918
134AKT20.30376530
135GRK70.30190782
136TTK0.28702662
137MAPK10.25995260
138KIT0.25880664
139JAK10.25442347
140CDK150.25042192

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.10655247
2Focal adhesion_Homo sapiens_hsa045102.44451035
3Basal cell carcinoma_Homo sapiens_hsa052172.25210403
4Protein digestion and absorption_Homo sapiens_hsa049742.18738228
5Axon guidance_Homo sapiens_hsa043602.07593504
6Amoebiasis_Homo sapiens_hsa051462.00011649
7Hedgehog signaling pathway_Homo sapiens_hsa043401.92387537
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90061877
9TGF-beta signaling pathway_Homo sapiens_hsa043501.85233008
10Proteoglycans in cancer_Homo sapiens_hsa052051.78699823
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70843898
12Hippo signaling pathway_Homo sapiens_hsa043901.66632092
13Adherens junction_Homo sapiens_hsa045201.62821352
14Dilated cardiomyopathy_Homo sapiens_hsa054141.59595400
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.52462544
16Wnt signaling pathway_Homo sapiens_hsa043101.48465714
17Melanogenesis_Homo sapiens_hsa049161.48459347
18PI3K-Akt signaling pathway_Homo sapiens_hsa041511.40157962
19MicroRNAs in cancer_Homo sapiens_hsa052061.30168397
20Malaria_Homo sapiens_hsa051441.30138553
21Melanoma_Homo sapiens_hsa052181.28939216
22Tight junction_Homo sapiens_hsa045301.24050488
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22312257
24Small cell lung cancer_Homo sapiens_hsa052221.21302353
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21104517
26Renin secretion_Homo sapiens_hsa049241.21059270
27Thyroid hormone synthesis_Homo sapiens_hsa049181.20815173
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.19986868
29Cocaine addiction_Homo sapiens_hsa050301.18471004
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16943469
31Thyroid cancer_Homo sapiens_hsa052161.16517173
32Pathways in cancer_Homo sapiens_hsa052001.15108216
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.14618454
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.14362227
35Rap1 signaling pathway_Homo sapiens_hsa040151.13844693
36Gastric acid secretion_Homo sapiens_hsa049711.13716156
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12892378
38GnRH signaling pathway_Homo sapiens_hsa049121.12719542
39Prostate cancer_Homo sapiens_hsa052151.09978878
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09472776
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08299798
42Gap junction_Homo sapiens_hsa045401.07649250
43Bladder cancer_Homo sapiens_hsa052191.04915712
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04207119
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03267706
46Renal cell carcinoma_Homo sapiens_hsa052111.03264618
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02947114
48Prion diseases_Homo sapiens_hsa050201.02086686
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01908561
50Long-term depression_Homo sapiens_hsa047301.01398966
51Ras signaling pathway_Homo sapiens_hsa040141.00437752
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98970968
53Glioma_Homo sapiens_hsa052140.96997734
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96979891
55Amphetamine addiction_Homo sapiens_hsa050310.95556338
56Salivary secretion_Homo sapiens_hsa049700.94775586
57Serotonergic synapse_Homo sapiens_hsa047260.94265858
58Estrogen signaling pathway_Homo sapiens_hsa049150.94190047
59Ovarian steroidogenesis_Homo sapiens_hsa049130.92803039
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.89598548
61Complement and coagulation cascades_Homo sapiens_hsa046100.88483699
62Circadian entrainment_Homo sapiens_hsa047130.85447519
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84349480
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83131515
65Endometrial cancer_Homo sapiens_hsa052130.82590324
66Platelet activation_Homo sapiens_hsa046110.81570125
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81059145
68Dorso-ventral axis formation_Homo sapiens_hsa043200.79708279
69Phagosome_Homo sapiens_hsa041450.78482843
70cAMP signaling pathway_Homo sapiens_hsa040240.77801533
71Glutamatergic synapse_Homo sapiens_hsa047240.76105706
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74524254
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74479074
74Oxytocin signaling pathway_Homo sapiens_hsa049210.73889008
75Rheumatoid arthritis_Homo sapiens_hsa053230.73392639
76Viral myocarditis_Homo sapiens_hsa054160.73223702
77Cholinergic synapse_Homo sapiens_hsa047250.72226568
78Lysine degradation_Homo sapiens_hsa003100.72212124
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71891119
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71812371
81Calcium signaling pathway_Homo sapiens_hsa040200.69994356
82Dopaminergic synapse_Homo sapiens_hsa047280.69820310
83MAPK signaling pathway_Homo sapiens_hsa040100.69199895
84Ether lipid metabolism_Homo sapiens_hsa005650.68828056
85ErbB signaling pathway_Homo sapiens_hsa040120.68630276
86Pancreatic cancer_Homo sapiens_hsa052120.67920498
87Steroid biosynthesis_Homo sapiens_hsa001000.67284858
88p53 signaling pathway_Homo sapiens_hsa041150.67003974
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65720606
90Taste transduction_Homo sapiens_hsa047420.64898094
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.64608815
92Autoimmune thyroid disease_Homo sapiens_hsa053200.64289208
93African trypanosomiasis_Homo sapiens_hsa051430.64037362
94Toxoplasmosis_Homo sapiens_hsa051450.63369885
95Colorectal cancer_Homo sapiens_hsa052100.62155039
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62147857
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61516901
98Vibrio cholerae infection_Homo sapiens_hsa051100.60755017
99Choline metabolism in cancer_Homo sapiens_hsa052310.60549857
100Chronic myeloid leukemia_Homo sapiens_hsa052200.57471813
101Sphingolipid metabolism_Homo sapiens_hsa006000.57429466
102Mineral absorption_Homo sapiens_hsa049780.57045093
103Long-term potentiation_Homo sapiens_hsa047200.56510023
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56372136
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54894794
106mTOR signaling pathway_Homo sapiens_hsa041500.53591286
107Non-small cell lung cancer_Homo sapiens_hsa052230.52923445
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.52724623
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52574372
110AMPK signaling pathway_Homo sapiens_hsa041520.51831019
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49123234
112VEGF signaling pathway_Homo sapiens_hsa043700.49088662
113Nicotine addiction_Homo sapiens_hsa050330.48465826
114Notch signaling pathway_Homo sapiens_hsa043300.47724282
115Endocytosis_Homo sapiens_hsa041440.47582456
116Salmonella infection_Homo sapiens_hsa051320.47068940
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46980285
118FoxO signaling pathway_Homo sapiens_hsa040680.45156613
119HTLV-I infection_Homo sapiens_hsa051660.45153634
120Cell cycle_Homo sapiens_hsa041100.41836711
121N-Glycan biosynthesis_Homo sapiens_hsa005100.41491510
122Circadian rhythm_Homo sapiens_hsa047100.40577139
123Alcoholism_Homo sapiens_hsa050340.38887803
124Renin-angiotensin system_Homo sapiens_hsa046140.35737144
125Insulin signaling pathway_Homo sapiens_hsa049100.34037221
126Prolactin signaling pathway_Homo sapiens_hsa049170.29854783
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29175649
128Inositol phosphate metabolism_Homo sapiens_hsa005620.28570276
129Glucagon signaling pathway_Homo sapiens_hsa049220.28350105
130Pancreatic secretion_Homo sapiens_hsa049720.27068231
131Pertussis_Homo sapiens_hsa051330.24219402
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24142884

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