ANTXR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06561164
2low-density lipoprotein particle clearance (GO:0034383)3.57660166
3positive regulation of gamma-delta T cell activation (GO:0046645)3.43218150
4cell adhesion mediated by integrin (GO:0033627)3.42058215
5negative regulation of interleukin-12 production (GO:0032695)3.40733476
6regulation of T-helper 1 cell differentiation (GO:0045625)3.27055304
7positive regulation by symbiont of host defense response (GO:0052509)3.24332830
8modulation by symbiont of host defense response (GO:0052031)3.24332830
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24332830
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24332830
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.24332830
12modulation by symbiont of host immune response (GO:0052553)3.24332830
13regulation of cholesterol storage (GO:0010885)3.21668583
14protein localization to endosome (GO:0036010)3.18683154
15positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13730060
16membrane raft organization (GO:0031579)3.11300618
17hypotonic response (GO:0006971)3.09125938
18lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06247859
19apoptotic cell clearance (GO:0043277)2.98527041
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.98119754
21positive regulation of p38MAPK cascade (GO:1900745)2.94095313
22growth hormone receptor signaling pathway (GO:0060396)2.89990584
23regulation of interferon-beta biosynthetic process (GO:0045357)2.89587003
24complement activation, alternative pathway (GO:0006957)2.89569956
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.88669370
26negative regulation of cell killing (GO:0031342)2.88669370
27detection of molecule of bacterial origin (GO:0032490)2.87706809
28plasma lipoprotein particle clearance (GO:0034381)2.84702003
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84107832
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84107832
31regulation of T-helper 2 cell differentiation (GO:0045628)2.83453112
32fibril organization (GO:0097435)2.82300324
33antigen processing and presentation of endogenous antigen (GO:0019883)2.82046949
34vascular endothelial growth factor signaling pathway (GO:0038084)2.81062192
35regulation of vitamin D biosynthetic process (GO:0060556)2.80298001
36positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78798555
37detection of external biotic stimulus (GO:0098581)2.78441970
38cardiac myofibril assembly (GO:0055003)2.78344839
39positive regulation of lipid storage (GO:0010884)2.78068205
40regulation of interleukin-12 biosynthetic process (GO:0045075)2.76088703
41detection of other organism (GO:0098543)2.75647398
42regulation of sequestering of triglyceride (GO:0010889)2.74957578
43positive regulation of interferon-alpha production (GO:0032727)2.73412745
44regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73053015
45response to host defenses (GO:0052200)2.71261628
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71261628
47response to host (GO:0075136)2.71261628
48regulation of complement activation (GO:0030449)2.69312337
49negative regulation of nitric oxide biosynthetic process (GO:0045019)2.68293844
50regulation of protein activation cascade (GO:2000257)2.68136663
51positive regulation of fatty acid beta-oxidation (GO:0032000)2.67626237
52endodermal cell differentiation (GO:0035987)2.67136592
53fatty acid transmembrane transport (GO:1902001)2.65043702
54cellular response to type I interferon (GO:0071357)2.64320229
55type I interferon signaling pathway (GO:0060337)2.64320229
56macrophage activation involved in immune response (GO:0002281)2.62846843
57response to type I interferon (GO:0034340)2.61965535
58regulation of interferon-alpha production (GO:0032647)2.61252378
59peptidyl-glutamic acid carboxylation (GO:0017187)2.60906194
60protein carboxylation (GO:0018214)2.60906194
61negative regulation of fibrinolysis (GO:0051918)2.58394285
62barbed-end actin filament capping (GO:0051016)2.57591661
63positive regulation of blood coagulation (GO:0030194)2.56538112
64positive regulation of hemostasis (GO:1900048)2.56538112
65germinal center formation (GO:0002467)2.56399697
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.56398460
67neutrophil activation involved in immune response (GO:0002283)2.55642015
68T-helper 1 type immune response (GO:0042088)2.54636541
69regulation of T cell tolerance induction (GO:0002664)2.52546793
70negative regulation of interleukin-17 production (GO:0032700)2.52540549
71granulocyte activation (GO:0036230)2.51384176
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.51337191
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49381033
74positive regulation of type 2 immune response (GO:0002830)2.48818967
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.48393386
76sarcomere organization (GO:0045214)2.48265500
77negative regulation of lipid storage (GO:0010888)2.47422824
78regulation of type 2 immune response (GO:0002828)2.47420609
79cellular response to growth hormone stimulus (GO:0071378)2.47016553
80extracellular fibril organization (GO:0043206)2.46478219
81regulation of membrane protein ectodomain proteolysis (GO:0051043)2.45821200
82substrate-dependent cell migration (GO:0006929)2.45675561
83positive regulation of coagulation (GO:0050820)2.45436977
84mature B cell differentiation involved in immune response (GO:0002313)2.44818328
85negative regulation of monooxygenase activity (GO:0032769)2.44393001
86regulation of macrophage cytokine production (GO:0010935)2.43689457
87regulation of tolerance induction (GO:0002643)2.43258434
88collagen fibril organization (GO:0030199)2.42795596
89neutrophil activation (GO:0042119)2.42425523
90detection of biotic stimulus (GO:0009595)2.40653931
91regulation of macrophage derived foam cell differentiation (GO:0010743)2.40000368
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.39788734
93positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.39099390
94phospholipid homeostasis (GO:0055091)2.39050430
95positive regulation of natural killer cell differentiation (GO:0032825)2.38975393
96negative regulation of erythrocyte differentiation (GO:0045647)2.38873703
97positive regulation of tolerance induction (GO:0002645)2.38586469
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38228934
99regulation of monocyte chemotaxis (GO:0090025)2.38090728
100regulation of necroptotic process (GO:0060544)2.37725195
101response to peptidoglycan (GO:0032494)2.37330136
102positive regulation of macrophage cytokine production (GO:0060907)2.37314532
103regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.36925847
104negative regulation of nitric-oxide synthase activity (GO:0051001)2.36741588
105positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.36739259
106cellular extravasation (GO:0045123)2.36689121
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.34619440
108pinocytosis (GO:0006907)2.34404447
109positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.33955656
110skin morphogenesis (GO:0043589)2.33954338
111positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33905205
112detection of bacterium (GO:0016045)2.32315345
113positive regulation of fatty acid oxidation (GO:0046321)2.32094949
114stress fiber assembly (GO:0043149)2.31019483
115basement membrane organization (GO:0071711)2.30184927
116macrophage activation (GO:0042116)2.30041775
117positive regulation of interleukin-6 production (GO:0032755)2.30035619
118regulation of vitamin metabolic process (GO:0030656)2.29938202
119positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.29535608
120negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.29013384
121negative regulation of T-helper cell differentiation (GO:0045623)2.29013384
122bundle of His cell to Purkinje myocyte communication (GO:0086069)2.28701056
123positive regulation of tumor necrosis factor production (GO:0032760)2.27228524
124regulation of fibrinolysis (GO:0051917)2.27169954
125myofibril assembly (GO:0030239)2.26647470
126carnitine shuttle (GO:0006853)2.25198192
127regulation of triglyceride catabolic process (GO:0010896)2.25088569
128negative regulation of type 2 immune response (GO:0002829)2.24986368
129interferon-gamma-mediated signaling pathway (GO:0060333)2.24944877
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.24942050
131positive regulation of extracellular matrix organization (GO:1903055)2.24256406
132regulation of fatty acid beta-oxidation (GO:0031998)2.24140331
1332-oxoglutarate metabolic process (GO:0006103)2.24130454
134mesodermal cell differentiation (GO:0048333)2.24025162
135defense response to protozoan (GO:0042832)2.23277860
136positive regulation of receptor recycling (GO:0001921)2.22389853
137regulation of mast cell degranulation (GO:0043304)2.21445851
138regulation of mononuclear cell migration (GO:0071675)2.21309061
139lymphocyte chemotaxis (GO:0048247)2.21090276
140negative regulation of cytokine production involved in immune response (GO:0002719)2.20810537
141regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.19126885
142fibrinolysis (GO:0042730)2.18633559
143fibroblast migration (GO:0010761)2.18599230
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18424054
145regulation of lipid storage (GO:0010883)2.18403905
146immunoglobulin mediated immune response (GO:0016064)2.18067207
147collagen metabolic process (GO:0032963)2.18051992
148positive regulation of lipid catabolic process (GO:0050996)2.17670019
149regulation of p38MAPK cascade (GO:1900744)2.16075628
150valine metabolic process (GO:0006573)2.15975753
151response to muramyl dipeptide (GO:0032495)2.15018584
152negative regulation of fatty acid transport (GO:2000192)2.13825127
153negative regulation of granulocyte differentiation (GO:0030853)2.13021106
154pathway-restricted SMAD protein phosphorylation (GO:0060389)2.12950563
155cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.12910292
156regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.12295932
157alpha-linolenic acid metabolic process (GO:0036109)2.10952505
158response to host immune response (GO:0052572)2.10468896
159response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.10468896
160regulation of macrophage chemotaxis (GO:0010758)2.10179137
161regulation of fatty acid oxidation (GO:0046320)2.09606579
162collagen catabolic process (GO:0030574)2.09219205
163response to fluid shear stress (GO:0034405)2.08533597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.02145793
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.81928054
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.71156312
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27231929
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12840885
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.99967389
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.97916543
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.86677606
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.76922358
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.73141494
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72903026
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69436976
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.64248789
14CLOCK_20551151_ChIP-Seq_293T_Human2.61267754
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60580809
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54170033
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47502860
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.45369931
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.42043371
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36198449
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35942745
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28081354
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27954340
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18376879
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17958207
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.04724590
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98992907
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.98626397
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.91232317
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87085334
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81207688
32MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81118553
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78797485
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74916787
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73450090
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.69879709
37* CJUN_26792858_Chip-Seq_BT549_Human1.63200884
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.63048520
39* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62561321
40RUNX_20019798_ChIP-Seq_JUKART_Human1.57652804
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56127862
42VDR_24787735_ChIP-Seq_THP-1_Human1.54703075
43GATA1_22025678_ChIP-Seq_K562_Human1.52530073
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.51955652
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.49690523
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.49690523
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49460040
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48962974
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47693020
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.47212877
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46885727
52* SPI1_23547873_ChIP-Seq_NB4_Human1.44819992
53* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44171973
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.41967624
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.39346096
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39322851
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37651469
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37651469
59* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37595267
60* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37595267
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37508284
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.33804544
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33210955
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31499258
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30024802
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28006136
67PU_27001747_Chip-Seq_BMDM_Mouse1.23549738
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22330238
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22044274
70VDR_21846776_ChIP-Seq_THP-1_Human1.21693297
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21195407
72MAF_26560356_Chip-Seq_TH1_Human1.21002561
73SPI1_23127762_ChIP-Seq_K562_Human1.20141271
74STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19694086
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19681915
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.19259563
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18505551
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16535030
79* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15524480
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.14792200
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14684919
82SCL_19346495_ChIP-Seq_HPC-7_Human1.14502695
83BRD4_25478319_ChIP-Seq_HGPS_Human1.13402924
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12937146
85PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12796407
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12475090
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11826414
88VDR_24763502_ChIP-Seq_THP-1_Human1.10815369
89* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10584143
90MYB_26560356_Chip-Seq_TH2_Human1.09332558
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09301385
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08861292
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.08711155
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08608497
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07731624
96* SOX2_20726797_ChIP-Seq_SW620_Human1.07630852
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04074421
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03355752
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01879399
100TCF7_22412390_ChIP-Seq_EML_Mouse1.01835767
101GATA2_19941826_ChIP-Seq_K562_Human1.00528205
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99877125
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97410399
104EGR1_19032775_ChIP-ChIP_M12_Human0.96704158
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96107451
106MYB_26560356_Chip-Seq_TH1_Human0.94209675
107* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94165475
108* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94088403
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92812973
110SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91851143
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91687611
112SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91613672
113GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90522638
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90439937
115GATA3_27048872_Chip-Seq_THYMUS_Human0.90376246
116TP53_16413492_ChIP-PET_HCT116_Human0.90254188
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.90066372
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.89940957
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88520337
120GATA1_19941826_ChIP-Seq_K562_Human0.87798844
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.85979617
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85645572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.32765655
2MP0003705_abnormal_hypodermis_morpholog2.88372304
3MP0005275_abnormal_skin_tensile2.55006365
4MP0003279_aneurysm2.28383245
5MP0003436_decreased_susceptibility_to2.21117850
6MP0003950_abnormal_plasma_membrane2.15177644
7MP0004084_abnormal_cardiac_muscle2.14888247
8MP0004510_myositis2.13931086
9MP0003300_gastrointestinal_ulcer1.92054450
10MP0000343_altered_response_to1.91914648
11MP0010368_abnormal_lymphatic_system1.91853844
12MP0003303_peritoneal_inflammation1.91350768
13MP0001835_abnormal_antigen_presentation1.86221570
14MP0002254_reproductive_system_inflammat1.85236016
15MP0003566_abnormal_cell_adhesion1.79127098
16MP0003828_pulmonary_edema1.77707587
17MP0005503_abnormal_tendon_morphology1.73769055
18MP0002837_dystrophic_cardiac_calcinosis1.73752368
19MP0005360_urolithiasis1.72439369
20MP0001542_abnormal_bone_strength1.68739253
21MP0002138_abnormal_hepatobiliary_system1.62989301
22MP0003191_abnormal_cellular_cholesterol1.59383431
23MP0005451_abnormal_body_composition1.58323232
24MP0009840_abnormal_foam_cell1.56969510
25MP0002419_abnormal_innate_immunity1.56117162
26MP0008004_abnormal_stomach_pH1.56043294
27MP0001958_emphysema1.54522908
28MP0004130_abnormal_muscle_cell1.53264751
29MP0004883_abnormal_blood_vessel1.52272621
30MP0000685_abnormal_immune_system1.51396586
31MP0001533_abnormal_skeleton_physiology1.51054078
32MP0002139_abnormal_hepatobiliary_system1.49828538
33MP0003724_increased_susceptibility_to1.48959726
34MP0006054_spinal_hemorrhage1.47411374
35* MP0009785_altered_susceptibility_to1.44779147
36MP0005058_abnormal_lysosome_morphology1.44575433
37MP0002166_altered_tumor_susceptibility1.43382822
38MP0000767_abnormal_smooth_muscle1.43136382
39MP0005365_abnormal_bile_salt1.40580795
40MP0003075_altered_response_to1.38250689
41MP0003252_abnormal_bile_duct1.37060044
42MP0004272_abnormal_basement_membrane1.36491159
43MP0005023_abnormal_wound_healing1.33535534
44MP0010352_gastrointestinal_tract_polyps1.33267277
45MP0000751_myopathy1.32527046
46MP0001879_abnormal_lymphatic_vessel1.31802025
47MP0004036_abnormal_muscle_relaxation1.31677308
48MP0009384_cardiac_valve_regurgitation1.29185638
49MP0006082_CNS_inflammation1.28567515
50MP0002148_abnormal_hypersensitivity_rea1.27997286
51MP0001790_abnormal_immune_system1.27820871
52MP0005387_immune_system_phenotype1.27820871
53MP0009278_abnormal_bone_marrow1.26548714
54MP0005000_abnormal_immune_tolerance1.24184428
55MP0009764_decreased_sensitivity_to1.23953228
56MP0005085_abnormal_gallbladder_physiolo1.23808582
57MP0010630_abnormal_cardiac_muscle1.22873741
58MP0005330_cardiomyopathy1.21924265
59MP0002972_abnormal_cardiac_muscle1.21919005
60MP0002998_abnormal_bone_remodeling1.21504381
61MP0002933_joint_inflammation1.21408568
62MP0003448_altered_tumor_morphology1.20408098
63MP0008775_abnormal_heart_ventricle1.20301402
64MP0002332_abnormal_exercise_endurance1.20269128
65MP0010329_abnormal_lipoprotein_level1.20017955
66MP0005165_increased_susceptibility_to1.18305757
67MP0001544_abnormal_cardiovascular_syste1.17492348
68MP0005385_cardiovascular_system_phenoty1.17492348
69* MP0005025_abnormal_response_to1.16526368
70MP0002877_abnormal_melanocyte_morpholog1.16288063
71MP0003172_abnormal_lysosome_physiology1.16001968
72MP0000750_abnormal_muscle_regeneration1.15549530
73MP0003045_fibrosis1.15446172
74MP0005671_abnormal_response_to1.14823880
75MP0003091_abnormal_cell_migration1.14480605
76MP0002060_abnormal_skin_morphology1.13878483
77MP0005595_abnormal_vascular_smooth1.13163457
78MP0005464_abnormal_platelet_physiology1.12811246
79MP0004087_abnormal_muscle_fiber1.12548185
80MP0002452_abnormal_antigen_presenting1.10621071
81MP0005166_decreased_susceptibility_to1.10612898
82MP0003763_abnormal_thymus_physiology1.10395426
83MP0001853_heart_inflammation1.09808233
84MP0008260_abnormal_autophagy1.09250270
85MP0002006_tumorigenesis1.08285166
86MP0003453_abnormal_keratinocyte_physiol1.07471741
87MP0000465_gastrointestinal_hemorrhage1.06592837
88MP0004947_skin_inflammation1.06504438
89MP0000858_altered_metastatic_potential1.04642037
90MP0000609_abnormal_liver_physiology1.04062991
91MP0001800_abnormal_humoral_immune1.02996599
92MP0004215_abnormal_myocardial_fiber1.01509386
93MP0000249_abnormal_blood_vessel1.00474674
94MP0008875_abnormal_xenobiotic_pharmacok1.00144816
95MP0008469_abnormal_protein_level0.99423549
96MP0000733_abnormal_muscle_development0.99204175
97MP0001845_abnormal_inflammatory_respons0.98583976
98MP0001851_eye_inflammation0.97763598
99MP0002896_abnormal_bone_mineralization0.96952408
100MP0002405_respiratory_system_inflammati0.95769137
101MP0005390_skeleton_phenotype0.94094546
102MP0005164_abnormal_response_to0.92613077
103MP0002723_abnormal_immune_serum0.91515516
104MP0000749_muscle_degeneration0.90037616
105MP0003795_abnormal_bone_structure0.89363615
106MP0000716_abnormal_immune_system0.89181181
107MP0000604_amyloidosis0.88974942
108MP0006138_congestive_heart_failure0.88746003
109MP0009763_increased_sensitivity_to0.88435413
110MP0010155_abnormal_intestine_physiology0.87824790
111MP0002128_abnormal_blood_circulation0.86787581
112MP0004808_abnormal_hematopoietic_stem0.86123251
113MP0005319_abnormal_enzyme/_coenzyme0.85806318
114MP0001243_abnormal_dermal_layer0.85138712
115MP0005666_abnormal_adipose_tissue0.84529339
116MP0005409_darkened_coat_color0.84387669
117MP0002295_abnormal_pulmonary_circulatio0.84331621
118MP0004185_abnormal_adipocyte_glucose0.83901335
119MP0001819_abnormal_immune_cell0.83307011
120MP0002420_abnormal_adaptive_immunity0.82556339
121MP0005397_hematopoietic_system_phenotyp0.82528289
122MP0001545_abnormal_hematopoietic_system0.82528289
123MP0002398_abnormal_bone_marrow0.82069259
124MP0005076_abnormal_cell_differentiation0.82000267
125MP0005257_abnormal_intraocular_pressure0.79950164
126MP0003656_abnormal_erythrocyte_physiolo0.78280981
127MP0002168_other_aberrant_phenotype0.74562408
128MP0001915_intracranial_hemorrhage0.72386856
129MP0009333_abnormal_splenocyte_physiolog0.71663918

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.65653657
2Premature rupture of membranes (HP:0001788)3.61463688
3Myocardial infarction (HP:0001658)3.58106978
4Systemic lupus erythematosus (HP:0002725)3.41847277
5Complement deficiency (HP:0004431)3.32970886
6Aortic dissection (HP:0002647)3.25611315
7Aortic aneurysm (HP:0004942)3.16005542
8Abnormality of liposaccharide metabolism (HP:0010968)3.15980813
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.15980813
10Abnormality of glycolipid metabolism (HP:0010969)3.15980813
11Deep venous thrombosis (HP:0002625)3.14998935
12Peritonitis (HP:0002586)3.12159565
13Right ventricular cardiomyopathy (HP:0011663)3.11980087
14Increased connective tissue (HP:0009025)3.11522729
15Recurrent gram-negative bacterial infections (HP:0005420)3.09476078
16Osteolytic defects of the hand bones (HP:0009699)3.01804868
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.01804868
18Hematochezia (HP:0002573)3.01174034
19Ankle contracture (HP:0006466)2.98418397
20Cerebral aneurysm (HP:0004944)2.97481122
21Ventricular tachycardia (HP:0004756)2.94656395
22Asymmetric septal hypertrophy (HP:0001670)2.92014789
23Eczematoid dermatitis (HP:0000976)2.87654571
24Abnormality of complement system (HP:0005339)2.87423060
25Amyloidosis (HP:0011034)2.81604311
26Recurrent abscess formation (HP:0002722)2.80583079
27Broad metatarsal (HP:0001783)2.66913519
28Spontaneous hematomas (HP:0007420)2.65572897
29Lipoatrophy (HP:0100578)2.64037253
30Myositis (HP:0100614)2.61742351
31Vertebral compression fractures (HP:0002953)2.60646794
32Xanthomatosis (HP:0000991)2.53721322
33Recurrent bacterial skin infections (HP:0005406)2.52983435
34Sudden death (HP:0001699)2.50069264
35Orchitis (HP:0100796)2.43288598
36Glomerulonephritis (HP:0000099)2.42113313
37Hypoalphalipoproteinemia (HP:0003233)2.41746471
38Esophageal varix (HP:0002040)2.40944115
39Mitral valve prolapse (HP:0001634)2.39034770
40Gastrointestinal infarctions (HP:0005244)2.36719357
41Exercise-induced muscle cramps (HP:0003710)2.34736685
42Cervical subluxation (HP:0003308)2.28607391
43Nephritis (HP:0000123)2.27682250
44Abnormality of the common coagulation pathway (HP:0010990)2.27060734
45Aortic regurgitation (HP:0001659)2.25073509
46Arterial thrombosis (HP:0004420)2.23430218
47Mitral stenosis (HP:0001718)2.22769245
48Mucopolysacchariduria (HP:0008155)2.21437166
49Urinary glycosaminoglycan excretion (HP:0003541)2.21437166
50Stomatitis (HP:0010280)2.20051693
51Type 1 muscle fiber predominance (HP:0003803)2.19782178
52Dilatation of the ascending aorta (HP:0005111)2.19255557
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.18775107
54Abnormality of polysaccharide metabolism (HP:0011012)2.18775107
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.18775107
56Epistaxis (HP:0000421)2.17985395
57Soft skin (HP:0000977)2.17427540
58Autoimmune thrombocytopenia (HP:0001973)2.16817297
59Aneurysm (HP:0002617)2.16787192
60Elevated erythrocyte sedimentation rate (HP:0003565)2.16042190
61Arterial tortuosity (HP:0005116)2.15440117
62Atrial fibrillation (HP:0005110)2.14736231
63Pulmonary infiltrates (HP:0002113)2.13929592
64Muscle fiber splitting (HP:0003555)2.13272491
65Tetraparesis (HP:0002273)2.12472667
66Hyporeflexia of lower limbs (HP:0002600)2.11548943
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10913345
68Vascular tortuosity (HP:0004948)2.09978863
69Joint hemorrhage (HP:0005261)2.08845492
70Thoracolumbar scoliosis (HP:0002944)2.08649142
71Abnormality of proline metabolism (HP:0010907)2.07479755
72Hydroxyprolinuria (HP:0003080)2.07479755
73Axonal loss (HP:0003447)2.07146141
74Spondylolisthesis (HP:0003302)2.06782835
75Increased density of long bones (HP:0006392)2.06155490
76Striae distensae (HP:0001065)2.04129820
77Increased variability in muscle fiber diameter (HP:0003557)1.99068351
78Blue sclerae (HP:0000592)1.97512026
79Lymphangioma (HP:0100764)1.96868319
80T lymphocytopenia (HP:0005403)1.96587635
81Atrophic scars (HP:0001075)1.96263154
82Mediastinal lymphadenopathy (HP:0100721)1.95851118
83Keratoconjunctivitis (HP:0001096)1.95046534
84Impaired platelet aggregation (HP:0003540)1.94776627
85Abnormal platelet function (HP:0011869)1.94776627
86Joint stiffness (HP:0001387)1.94171698
87Primary atrial arrhythmia (HP:0001692)1.93901002
88Vacuolated lymphocytes (HP:0001922)1.93429586
89Fragile skin (HP:0001030)1.92412964
90Conjunctival telangiectasia (HP:0000524)1.92326644
91Hemoptysis (HP:0002105)1.91318689
92Abnormality of the left ventricular outflow tract (HP:0011103)1.91049461
93Subaortic stenosis (HP:0001682)1.91049461
94Abnormality of macrophages (HP:0004311)1.89844491
95Gingival bleeding (HP:0000225)1.89121902
96Thick nail (HP:0001805)1.88702423
97Abnormality of T cell number (HP:0011839)1.87479874
98Absent frontal sinuses (HP:0002688)1.87209489
99Prolonged bleeding time (HP:0003010)1.87153990
100Optic neuritis (HP:0100653)1.86795865
101Retrobulbar optic neuritis (HP:0100654)1.86795865
102Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85952360
103Spinal rigidity (HP:0003306)1.85804676
104Chest pain (HP:0100749)1.84995975
105Increased mean platelet volume (HP:0011877)1.84964305
106Gingivitis (HP:0000230)1.84891578
107Cellulitis (HP:0100658)1.84787448
108Recurrent skin infections (HP:0001581)1.84728978
109Abnormality of skeletal muscle fiber size (HP:0012084)1.83814517
110Vasculitis (HP:0002633)1.83248911
111Interstitial pulmonary disease (HP:0006530)1.82984936
112Supraventricular arrhythmia (HP:0005115)1.82913678
113Distal lower limb muscle weakness (HP:0009053)1.82454548
114Wormian bones (HP:0002645)1.82399096
115Abnormal platelet volume (HP:0011876)1.82129228
116Thin bony cortex (HP:0002753)1.81133971
117Supraventricular tachycardia (HP:0004755)1.80533534
118Hypoglycemic coma (HP:0001325)1.80158611
119Recurrent fungal infections (HP:0002841)1.79687432
120Polycythemia (HP:0001901)1.79646844
121Mucosal telangiectasiae (HP:0100579)1.79241175
122Ovoid vertebral bodies (HP:0003300)1.79220489
123Syringomyelia (HP:0003396)1.79128986
124Spinal cord lesions (HP:0100561)1.79128986
125Abnormality of the pericardium (HP:0001697)1.78928376
126Dilated cardiomyopathy (HP:0001644)1.78693291
127Pulmonary embolism (HP:0002204)1.78503072
128Facial diplegia (HP:0001349)1.78338031
129Genu recurvatum (HP:0002816)1.77693033
130Nonimmune hydrops fetalis (HP:0001790)1.77542841
131Autoimmune hemolytic anemia (HP:0001890)1.77441192
132Joint laxity (HP:0001388)1.76420778
133Persistence of primary teeth (HP:0006335)1.75902191
134Increased cerebral lipofuscin (HP:0011813)1.75634485
135Bruising susceptibility (HP:0000978)1.75380058
136Abnormality of skull ossification (HP:0002703)1.74800741
137Follicular hyperkeratosis (HP:0007502)1.73227860
138Hypolipoproteinemia (HP:0010981)1.73198582
139Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73069133
140Distal lower limb amyotrophy (HP:0008944)1.73002388
141Shallow orbits (HP:0000586)1.72826387
142Keratoconjunctivitis sicca (HP:0001097)1.71396275
143Dysostosis multiplex (HP:0000943)1.71191000
144Hypercholesterolemia (HP:0003124)1.70860293
145Periodontitis (HP:0000704)1.70672306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN3.59131582
2TRIB33.11829849
3PKN23.03069507
4TGFBR22.76826810
5ERN12.50540493
6TBK12.26522737
7NEK92.23371812
8RIPK42.12153671
9TYK22.11838066
10MAP3K142.07175689
11FGFR41.96540649
12PRPF4B1.91286079
13LATS11.85655944
14JAK11.74315724
15KIT1.72690990
16MYLK1.71760393
17FLT31.64174336
18DMPK1.60426759
19SIK11.56491231
20JAK31.56097483
21RIPK11.55342735
22EPHB11.52904167
23MAP2K31.50319822
24STK241.49730637
25KDR1.47746860
26FGFR31.44616617
27EPHA31.44129193
28TRPM71.42099472
29PDGFRA1.41155369
30PTK61.40031597
31LRRK21.38994419
32TAOK21.36355176
33MAP3K61.34602800
34BMPR21.31527226
35TIE11.23973548
36FRK1.23516399
37IKBKB1.23299576
38STK101.21735855
39RPS6KA41.20147457
40CDC42BPA1.20136389
41MAP3K31.17489357
42DDR21.14485088
43TXK1.13037262
44STK31.12687349
45IKBKE1.12640968
46LMTK21.12502746
47IRAK31.12109715
48PIK3CG1.09900292
49CSK1.09073487
50TAOK31.09072551
51EPHB21.08748087
52CAMK1D1.07029524
53MAP4K11.06774144
54OBSCN1.06251900
55IRAK41.03741835
56CHUK1.02974415
57BLK1.00488430
58FES1.00408124
59AKT30.99924795
60PIK3CA0.91411752
61CSF1R0.90811574
62IRAK10.90034113
63ZAP700.89949048
64MAP3K100.89918719
65MAP3K110.89776334
66FGR0.89222028
67MAP3K10.88961705
68CLK10.88680761
69ITK0.86271065
70JAK20.84477885
71SYK0.84126620
72PRKAA20.83196351
73CDK60.82114487
74TEC0.79286414
75NUAK10.78880686
76PRKG20.77785458
77MOS0.77301472
78TGFBR10.77123131
79PDGFRB0.75128093
80PAK40.74000067
81HCK0.73384846
82GRK60.71758432
83PAK20.71345591
84MAPK70.70589790
85HIPK20.70445093
86NME20.67232463
87BCKDK0.65737514
88LYN0.65576715
89KSR20.65371135
90BMX0.64190218
91MST1R0.63541033
92TAOK10.61821615
93PTK20.61156867
94PRKD20.60614231
95PIM20.60547269
96NLK0.59900938
97STK380.59851833
98ILK0.59808958
99TESK10.58915095
100BTK0.57255232
101MAPKAPK30.56850471
102ABL20.56402235
103STK40.54531551
104MARK20.54525103
105MAP3K70.53876321
106TESK20.51179171
107RET0.50971736
108GSK3A0.50401682
109MAP3K130.49547364
110WNK10.49394005
111PRKD10.49311509
112MATK0.49048554
113PIM10.48965360
114PTK2B0.48235725
115MELK0.47115874
116EGFR0.47074439
117ABL10.46573655
118IRAK20.45968971
119PDK40.45615864
120PDK30.45615864
121LCK0.45602018
122ROCK10.45547361
123EPHA20.45134516
124YES10.44991587
125MAP3K20.44966820
126IGF1R0.44619875
127MARK30.44509438
128MAPK110.42480678
129EEF2K0.41849517
130MAPKAPK20.41674557
131MAPK120.41230174
132MAP3K50.40772916
133GRK70.40318173
134ERBB40.40278757

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.11517490
2Complement and coagulation cascades_Homo sapiens_hsa046102.48738524
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32480603
4Caffeine metabolism_Homo sapiens_hsa002322.24159052
5Fatty acid degradation_Homo sapiens_hsa000712.09799330
6Leishmaniasis_Homo sapiens_hsa051402.04250937
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.85240554
8Malaria_Homo sapiens_hsa051441.73844983
9PPAR signaling pathway_Homo sapiens_hsa033201.68179081
10Osteoclast differentiation_Homo sapiens_hsa043801.67772296
11Allograft rejection_Homo sapiens_hsa053301.59030992
12ECM-receptor interaction_Homo sapiens_hsa045121.58541283
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58290373
14Graft-versus-host disease_Homo sapiens_hsa053321.54574228
15African trypanosomiasis_Homo sapiens_hsa051431.52029797
16Viral myocarditis_Homo sapiens_hsa054161.51400497
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.47534890
18Toxoplasmosis_Homo sapiens_hsa051451.46626698
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46188143
20Arginine biosynthesis_Homo sapiens_hsa002201.45855645
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41319241
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39888447
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38681595
24Focal adhesion_Homo sapiens_hsa045101.35410021
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.34710818
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34462603
27Tryptophan metabolism_Homo sapiens_hsa003801.34371631
28Pertussis_Homo sapiens_hsa051331.34065227
29Fatty acid metabolism_Homo sapiens_hsa012121.33453727
30Dilated cardiomyopathy_Homo sapiens_hsa054141.29144063
31Autoimmune thyroid disease_Homo sapiens_hsa053201.26475327
32Legionellosis_Homo sapiens_hsa051341.26210275
33Amoebiasis_Homo sapiens_hsa051461.26072063
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25786406
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24858427
36Starch and sucrose metabolism_Homo sapiens_hsa005001.22805623
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22316770
38Propanoate metabolism_Homo sapiens_hsa006401.22125262
39Nitrogen metabolism_Homo sapiens_hsa009101.21581424
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18195922
41Small cell lung cancer_Homo sapiens_hsa052221.16629794
42TNF signaling pathway_Homo sapiens_hsa046681.15711045
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.13960017
44Asthma_Homo sapiens_hsa053101.12548164
45Tuberculosis_Homo sapiens_hsa051521.12204555
46Lysosome_Homo sapiens_hsa041421.11322400
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11125913
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.08412072
49Insulin resistance_Homo sapiens_hsa049311.02607345
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99718639
51Proteoglycans in cancer_Homo sapiens_hsa052050.99136460
52Chronic myeloid leukemia_Homo sapiens_hsa052200.96293623
53Renal cell carcinoma_Homo sapiens_hsa052110.95066082
54T cell receptor signaling pathway_Homo sapiens_hsa046600.94301316
55Measles_Homo sapiens_hsa051620.94143229
56VEGF signaling pathway_Homo sapiens_hsa043700.93692813
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92631042
58Apoptosis_Homo sapiens_hsa042100.91168900
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90605834
60Adherens junction_Homo sapiens_hsa045200.90329801
61Prolactin signaling pathway_Homo sapiens_hsa049170.89111026
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88400171
63Phagosome_Homo sapiens_hsa041450.87002115
64Herpes simplex infection_Homo sapiens_hsa051680.86765689
65Peroxisome_Homo sapiens_hsa041460.86246153
66Pancreatic cancer_Homo sapiens_hsa052120.86099760
67Salmonella infection_Homo sapiens_hsa051320.85769589
68Shigellosis_Homo sapiens_hsa051310.84700320
69Prion diseases_Homo sapiens_hsa050200.84279772
70Type I diabetes mellitus_Homo sapiens_hsa049400.82214818
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.81374797
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.80055483
73Carbon metabolism_Homo sapiens_hsa012000.80044262
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79389307
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.79243178
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78785367
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78550207
78B cell receptor signaling pathway_Homo sapiens_hsa046620.78429140
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77113933
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75395416
81Non-small cell lung cancer_Homo sapiens_hsa052230.74571961
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74377407
83Platelet activation_Homo sapiens_hsa046110.74223022
84Antigen processing and presentation_Homo sapiens_hsa046120.73745822
85beta-Alanine metabolism_Homo sapiens_hsa004100.73197773
86Hematopoietic cell lineage_Homo sapiens_hsa046400.71984404
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71730011
88Endocytosis_Homo sapiens_hsa041440.70168940
89Other glycan degradation_Homo sapiens_hsa005110.69933740
90Retinol metabolism_Homo sapiens_hsa008300.68734333
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.68733944
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68359069
93Influenza A_Homo sapiens_hsa051640.67825880
94Lysine degradation_Homo sapiens_hsa003100.65550098
95Chemical carcinogenesis_Homo sapiens_hsa052040.65279976
96Phenylalanine metabolism_Homo sapiens_hsa003600.64417943
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.63656160
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63614098
99Histidine metabolism_Homo sapiens_hsa003400.63399225
100Hepatitis B_Homo sapiens_hsa051610.62705675
101ABC transporters_Homo sapiens_hsa020100.60641449
102Fat digestion and absorption_Homo sapiens_hsa049750.60063563
103FoxO signaling pathway_Homo sapiens_hsa040680.58422545
104Acute myeloid leukemia_Homo sapiens_hsa052210.58341727
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56934728
106HIF-1 signaling pathway_Homo sapiens_hsa040660.55343186
107Prostate cancer_Homo sapiens_hsa052150.54825470
108Pathways in cancer_Homo sapiens_hsa052000.54408181
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53617671
110Notch signaling pathway_Homo sapiens_hsa043300.52884032
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52740757
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52245516
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51812700
114HTLV-I infection_Homo sapiens_hsa051660.51508719
115Rheumatoid arthritis_Homo sapiens_hsa053230.51296254
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50521967
117Dorso-ventral axis formation_Homo sapiens_hsa043200.50107975
118MicroRNAs in cancer_Homo sapiens_hsa052060.49944914
119Selenocompound metabolism_Homo sapiens_hsa004500.49887212
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48543427
121Rap1 signaling pathway_Homo sapiens_hsa040150.47844064
122Chemokine signaling pathway_Homo sapiens_hsa040620.47106158
123Viral carcinogenesis_Homo sapiens_hsa052030.46245091
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46152205
125Bladder cancer_Homo sapiens_hsa052190.45977953
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.45033605
127Pyruvate metabolism_Homo sapiens_hsa006200.44960905
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44705986
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44629571
130GnRH signaling pathway_Homo sapiens_hsa049120.44403744
131Protein digestion and absorption_Homo sapiens_hsa049740.43780374
132Bile secretion_Homo sapiens_hsa049760.43449809
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42903291
134Glioma_Homo sapiens_hsa052140.42656958
135Hepatitis C_Homo sapiens_hsa051600.42637188
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.41649392

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