ANTXRL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.84290905
2motile cilium assembly (GO:0044458)9.47660290
3reproduction (GO:0000003)9.46381120
4regulation of cilium movement (GO:0003352)9.40970571
5cilium movement (GO:0003341)8.30983847
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.70553805
7single fertilization (GO:0007338)7.68780392
8piRNA metabolic process (GO:0034587)7.46675802
9sperm capacitation (GO:0048240)7.41874304
10negative regulation of inclusion body assembly (GO:0090084)7.11929147
11male meiosis (GO:0007140)7.10527708
12synaptonemal complex organization (GO:0070193)6.99859822
13regulation of phosphoprotein phosphatase activity (GO:0043666)6.91086701
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.82627630
15synaptonemal complex assembly (GO:0007130)6.69650859
16spermatogenesis (GO:0007283)6.68681150
17male gamete generation (GO:0048232)6.66173551
18fertilization (GO:0009566)6.49787063
19organic cation transport (GO:0015695)6.47109181
20microtubule depolymerization (GO:0007019)6.44466063
21gamete generation (GO:0007276)6.11632859
22regulation of inclusion body assembly (GO:0090083)5.91626521
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.90874450
24positive regulation of catecholamine secretion (GO:0033605)5.82399554
25regulation of microtubule-based movement (GO:0060632)5.56589106
26calcium ion-dependent exocytosis (GO:0017156)5.52372184
27ventricular system development (GO:0021591)5.52085407
28germ cell development (GO:0007281)5.48994436
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.43270581
30male meiosis I (GO:0007141)5.20266340
31cell recognition (GO:0008037)4.95643256
32regulation of autophagic vacuole assembly (GO:2000785)4.85801223
33glycerol ether metabolic process (GO:0006662)4.84350896
34multicellular organismal reproductive process (GO:0048609)4.84325036
35left/right pattern formation (GO:0060972)4.82600170
36microtubule severing (GO:0051013)4.76559104
37regulation of ARF GTPase activity (GO:0032312)4.75795376
38phosphatidylethanolamine biosynthetic process (GO:0006646)4.75121210
39seminiferous tubule development (GO:0072520)4.71109130
40DNA methylation involved in gamete generation (GO:0043046)4.70058058
41chromosome condensation (GO:0030261)4.69409911
42chromosome organization involved in meiosis (GO:0070192)4.57215942
43ether metabolic process (GO:0018904)4.48553452
44DNA packaging (GO:0006323)4.48338603
45phosphatidylethanolamine metabolic process (GO:0046337)4.35564776
46regulation of oxidative stress-induced neuron death (GO:1903203)4.33865822
47meiotic nuclear division (GO:0007126)4.22862443
48relaxation of smooth muscle (GO:0044557)4.20422385
49spermatid nucleus differentiation (GO:0007289)4.17883011
50meiosis I (GO:0007127)4.15014567
51regulation of vacuole organization (GO:0044088)4.02123415
52chaperone-mediated protein complex assembly (GO:0051131)4.02109221
53genitalia morphogenesis (GO:0035112)3.90180246
54multicellular organismal development (GO:0007275)3.89846961
55potassium ion export (GO:0071435)3.80972589
56protein targeting to Golgi (GO:0000042)3.79030061
57protein polyglutamylation (GO:0018095)3.73999181
58establishment of protein localization to Golgi (GO:0072600)3.64547275
59nucleosome disassembly (GO:0006337)3.59832660
60protein-DNA complex disassembly (GO:0032986)3.59832660
61coenzyme catabolic process (GO:0009109)3.57793942
62meiotic cell cycle (GO:0051321)3.50158834
63sexual reproduction (GO:0019953)3.49260828
64protein localization to cilium (GO:0061512)3.43828604
65protein refolding (GO:0042026)3.41356003
66mast cell degranulation (GO:0043303)3.40514590
67mast cell activation involved in immune response (GO:0002279)3.40514590
68retrograde transport, vesicle recycling within Golgi (GO:0000301)3.39200680
69monoubiquitinated protein deubiquitination (GO:0035520)3.38492131
70single strand break repair (GO:0000012)3.37775355
71microtubule polymerization or depolymerization (GO:0031109)3.36286107
72response to acidic pH (GO:0010447)3.35449263
73cellular response to interleukin-15 (GO:0071350)3.33903170
74cGMP-mediated signaling (GO:0019934)3.32562443
75activation of protein kinase B activity (GO:0032148)3.32214286
76regulation of spindle checkpoint (GO:0090231)3.27889156
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.27694385
78positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26409532
79regulation of B cell receptor signaling pathway (GO:0050855)3.23148387
80regulation of oxidative phosphorylation (GO:0002082)3.21965108
81glycolytic process (GO:0006096)3.19495512
82negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.18832647
83tryptophan catabolic process (GO:0006569)3.17667180
84indole-containing compound catabolic process (GO:0042436)3.17667180
85indolalkylamine catabolic process (GO:0046218)3.17667180
86RNA localization (GO:0006403)3.17349879
87nucleoside diphosphate phosphorylation (GO:0006165)3.17148796
88amino-acid betaine transport (GO:0015838)3.12885748
89carnitine transport (GO:0015879)3.12885748
90polyol catabolic process (GO:0046174)3.12127368
91mitotic sister chromatid cohesion (GO:0007064)3.11089597
92androgen biosynthetic process (GO:0006702)3.10595069
93mast cell activation (GO:0045576)3.09122760
94nucleus organization (GO:0006997)3.03015007
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99808122
96male sex determination (GO:0030238)2.99227415
97regulation of T cell mediated cytotoxicity (GO:0001914)2.98425617
98alditol metabolic process (GO:0019400)2.98064249
99response to interleukin-15 (GO:0070672)2.97908203
100sequestering of actin monomers (GO:0042989)2.97413666
101carnitine transmembrane transport (GO:1902603)2.96026577
102positive regulation of Rab GTPase activity (GO:0032851)2.95341877
103regulation of Rab GTPase activity (GO:0032313)2.95341877
104GTP biosynthetic process (GO:0006183)2.93677474
105protein K11-linked deubiquitination (GO:0035871)2.92872375
106cellular extravasation (GO:0045123)2.88856353
107negative regulation of response to reactive oxygen species (GO:1901032)2.87685556
108microtubule-based movement (GO:0007018)2.87486478
109interferon-gamma secretion (GO:0072643)2.86760446
110cilium organization (GO:0044782)2.86245187
111positive regulation of gamma-delta T cell activation (GO:0046645)2.84188124
112diacylglycerol metabolic process (GO:0046339)2.83696490
113negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83188792
114negative regulation of cell killing (GO:0031342)2.83188792
115regulation of hydrogen peroxide-induced cell death (GO:1903205)2.83113394
116negative regulation of organelle assembly (GO:1902116)2.81762287
117RNA destabilization (GO:0050779)2.81597959
118regulation of dopamine secretion (GO:0014059)2.80255999
119meiotic cell cycle process (GO:1903046)2.77964553
120intraciliary transport (GO:0042073)2.77843013
121Leydig cell differentiation (GO:0033327)2.76757877
122axoneme assembly (GO:0035082)2.76206546
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75778706
124lactate metabolic process (GO:0006089)2.75300580
125positive regulation by symbiont of host defense response (GO:0052509)2.74401013
126modulation by symbiont of host defense response (GO:0052031)2.74401013
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74401013
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74401013
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.74401013
130modulation by symbiont of host immune response (GO:0052553)2.74401013
131cilium assembly (GO:0042384)2.73690543
132regulation of cellular extravasation (GO:0002691)2.72869418
133detection of molecule of bacterial origin (GO:0032490)2.71783918
134negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.70123783
135cilium morphogenesis (GO:0060271)2.69974518
136regulation of synaptic transmission, dopaminergic (GO:0032225)2.69719222
137xenobiotic catabolic process (GO:0042178)2.68844061
138positive regulation of glycolytic process (GO:0045821)2.68805138
139gene silencing by RNA (GO:0031047)2.68691342
140cellular component assembly involved in morphogenesis (GO:0010927)2.68373136
141synapsis (GO:0007129)2.67564140
142histone H3-K36 demethylation (GO:0070544)2.67534854
143peptidyl-glutamic acid modification (GO:0018200)2.66655653
144mitochondrion degradation (GO:0000422)2.66579633
145protein polymerization (GO:0051258)2.66191248
146glucan metabolic process (GO:0044042)2.65994067
147cellular glucan metabolic process (GO:0006073)2.65994067
148cellular response to pH (GO:0071467)2.63868836
149regulation of cilium assembly (GO:1902017)2.62621370
150UTP biosynthetic process (GO:0006228)2.62075041
151polyamine biosynthetic process (GO:0006596)2.59620615
152positive regulation of macrophage activation (GO:0043032)2.58830960
153regulation of response to osmotic stress (GO:0047484)2.57354268
154regulation of protein kinase C signaling (GO:0090036)2.54118856
155sperm motility (GO:0030317)14.2674219
156fusion of sperm to egg plasma membrane (GO:0007342)13.8016272
157acrosome reaction (GO:0007340)12.3108237
158sperm-egg recognition (GO:0035036)11.4388967
159cell wall macromolecule metabolic process (GO:0044036)11.2761157
160cell wall macromolecule catabolic process (GO:0016998)11.2761157
161multicellular organism reproduction (GO:0032504)11.1698691
162acrosome assembly (GO:0001675)10.9454359
163plasma membrane fusion (GO:0045026)10.4949251
164binding of sperm to zona pellucida (GO:0007339)10.4166557
165cell-cell recognition (GO:0009988)10.2267834
166axonemal dynein complex assembly (GO:0070286)10.2254843
167epithelial cilium movement (GO:0003351)10.1815459
168cilium or flagellum-dependent cell motility (GO:0001539)10.1577735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.50095171
2BP1_19119308_ChIP-ChIP_Hs578T_Human8.06370802
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.97610388
4EZH2_22144423_ChIP-Seq_EOC_Human4.81805575
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.00038525
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11583805
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human3.04310611
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.87880858
9IGF1R_20145208_ChIP-Seq_DFB_Human2.66752179
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54370699
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52300895
12AR_21572438_ChIP-Seq_LNCaP_Human2.51494555
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.42213732
14VDR_22108803_ChIP-Seq_LS180_Human2.32040683
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.28997901
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.22358084
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.16761923
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02622741
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02339861
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01805225
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01604857
22RUNX_20019798_ChIP-Seq_JUKART_Human2.00461776
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00164730
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.98952318
25ER_23166858_ChIP-Seq_MCF-7_Human1.96752344
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91510379
27GBX2_23144817_ChIP-Seq_PC3_Human1.90458480
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.84292343
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.83278060
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78353703
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75487230
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.72020740
33FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68457577
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68416917
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.68131574
36MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.66254763
37* STAT1_17558387_ChIP-Seq_HELA_Human1.65235359
38RAC3_21632823_ChIP-Seq_H3396_Human1.62517325
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.59165003
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58950736
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56606733
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55590774
43CBP_20019798_ChIP-Seq_JUKART_Human1.53045379
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53045379
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52256788
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49851698
47SPI1_23127762_ChIP-Seq_K562_Human1.49801523
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48608794
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45538429
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40327798
51OCT1_27270436_Chip-Seq_PROSTATE_Human1.39765841
52KDM2B_26808549_Chip-Seq_REH_Human1.39597140
53ERA_21632823_ChIP-Seq_H3396_Human1.39213837
54GATA3_21867929_ChIP-Seq_CD8_Mouse1.39040209
55TAL1_26923725_Chip-Seq_HPCs_Mouse1.37931808
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37895014
57AHR_22903824_ChIP-Seq_MCF-7_Human1.37267835
58SCL_19346495_ChIP-Seq_HPC-7_Human1.36690358
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35848214
60P53_21459846_ChIP-Seq_SAOS-2_Human1.33927318
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32620611
62LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32081543
63VDR_24787735_ChIP-Seq_THP-1_Human1.28971062
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28811051
65OCT4_20526341_ChIP-Seq_ESCs_Human1.27957516
66REST_21632747_ChIP-Seq_MESCs_Mouse1.27475346
67SMC4_20622854_ChIP-Seq_HELA_Human1.26973353
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.24635269
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.24234571
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24158547
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23182799
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.21434350
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21004282
74PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20763805
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20336907
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20336907
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20130954
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19944924
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19652846
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18976883
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18787802
82GATA3_26560356_Chip-Seq_TH2_Human1.18696894
83GF1_26923725_Chip-Seq_HPCs_Mouse1.18652199
84FUS_26573619_Chip-Seq_HEK293_Human1.18522626
85TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.17641407
86CTCF_27219007_Chip-Seq_Bcells_Human1.17561804
87GATA3_27048872_Chip-Seq_THYMUS_Human1.17007030
88* MYB_26560356_Chip-Seq_TH2_Human1.15442646
89* GATA3_21867929_ChIP-Seq_TH1_Mouse1.15308175
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15301304
91SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.14837148
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14785658
93BCAT_22108803_ChIP-Seq_LS180_Human1.14361751
94SPI1_20517297_ChIP-Seq_HL60_Human1.13959380
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13751118
96* MYB_26560356_Chip-Seq_TH1_Human1.13497612
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12688051
98E2F1_20622854_ChIP-Seq_HELA_Human1.12508810
99TAF15_26573619_Chip-Seq_HEK293_Human1.12480827
100PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12353086
101BCL6_27268052_Chip-Seq_Bcells_Human1.12284575
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11108229
103MYC_19829295_ChIP-Seq_ESCs_Human1.10578700
104MYC_27129775_Chip-Seq_CORNEA_Mouse1.10284532
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09830073
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09620334
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09595678
108P300_27268052_Chip-Seq_Bcells_Human1.09470651
109RUNX2_22187159_ChIP-Seq_PCA_Human1.09434213
110RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09232272
111RXR_22108803_ChIP-Seq_LS180_Human1.09141692
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08922609
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08309152
114ERG_20517297_ChIP-Seq_VCAP_Human1.07479785
115TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07382708
116SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07218208
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.05852686
118UTX_26944678_Chip-Seq_JUKART_Human1.05801442
119MAF_26560356_Chip-Seq_TH2_Human1.05273090
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.05083711
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04114517
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02640665
123RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01623777
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01103742
125PRDM14_20953172_ChIP-Seq_ESCs_Human1.00431811
126JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00380326
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99991590
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99845176
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98697396
130CTCF_20526341_ChIP-Seq_ESCs_Human0.98425697
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.97311887
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.97017599
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96750857
134* TBL1_22424771_ChIP-Seq_293T_Human0.96340560
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.96182603
136TP53_18474530_ChIP-ChIP_U2OS_Human0.95791747
137BCOR_27268052_Chip-Seq_Bcells_Human0.95640468
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.94621033
139GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94476406
140P300_19829295_ChIP-Seq_ESCs_Human0.94146443
141NFYB_21822215_ChIP-Seq_K562_Human0.93856701
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93722166
143GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93300742
144NANOG_20526341_ChIP-Seq_ESCs_Human0.92111062
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92105207
146AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92009587
147SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91729160
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91457838
149BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.91028155
150PHF8_20622854_ChIP-Seq_HELA_Human0.90974452
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90942468
152STAT1_20625510_ChIP-Seq_HELA_Human0.90870965
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.90224957
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.90205167
155SOX2_21211035_ChIP-Seq_LN229_Human0.89972619
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89897733
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.89834227
158RNF2_27304074_Chip-Seq_NSC_Mouse0.89770739
159P53_22387025_ChIP-Seq_ESCs_Mouse0.89531102
160AR_25329375_ChIP-Seq_VCAP_Human0.89354521
161FOXH1_21741376_ChIP-Seq_EPCs_Human0.89307145
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89219960
163P68_20966046_ChIP-Seq_HELA_Human0.89062811
164OCT4_18555785_Chip-Seq_ESCs_Mouse0.88885662
165SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88877242
166FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88702660
167GATA3_21878914_ChIP-Seq_MCF-7_Human0.88351116
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88297571
169RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88201842
170OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88095672
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87819850
172DROSHA_22980978_ChIP-Seq_HELA_Human0.86801247
173SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86328014
174HOXB7_26014856_ChIP-Seq_BT474_Human0.85438489
175FOXH1_21741376_ChIP-Seq_ESCs_Human0.85132989
176CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.83590423
177CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81645513

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.00296120
2MP0001929_abnormal_gametogenesis5.41334771
3MP0008004_abnormal_stomach_pH4.69598688
4MP0008877_abnormal_DNA_methylation4.16913202
5MP0002132_abnormal_respiratory_system3.68789803
6MP0003315_abnormal_perineum_morphology3.61522742
7MP0002210_abnormal_sex_determination3.34722683
8MP0002161_abnormal_fertility/fecundity3.27901901
9MP0003724_increased_susceptibility_to3.09038286
10MP0005670_abnormal_white_adipose2.95139832
11MP0001145_abnormal_male_reproductive2.82367642
12MP0000653_abnormal_sex_gland2.43493291
13MP0000465_gastrointestinal_hemorrhage2.38625075
14MP0003436_decreased_susceptibility_to2.37936398
15MP0002653_abnormal_ependyma_morphology2.32118411
16MP0004381_abnormal_hair_follicle2.01995270
17MP0005410_abnormal_fertilization16.4854542
18MP0005360_urolithiasis1.94497078
19MP0003646_muscle_fatigue1.89574282
20MP0009785_altered_susceptibility_to1.82640541
21MP0002419_abnormal_innate_immunity1.81064237
22MP0005623_abnormal_meninges_morphology1.78140942
23MP0001835_abnormal_antigen_presentation1.70674508
24MP0003828_pulmonary_edema1.64321805
25MP0002282_abnormal_trachea_morphology1.62736081
26MP0002160_abnormal_reproductive_system1.60614912
27MP0005025_abnormal_response_to1.59786496
28MP0001800_abnormal_humoral_immune1.58789491
29MP0003763_abnormal_thymus_physiology1.58057690
30MP0005671_abnormal_response_to1.56473175
31MP0002420_abnormal_adaptive_immunity1.54306452
32MP0001819_abnormal_immune_cell1.51115994
33MP0002723_abnormal_immune_serum1.50384239
34MP0001501_abnormal_sleep_pattern1.42656432
35MP0005000_abnormal_immune_tolerance1.41882578
36MP0001664_abnormal_digestion1.37779864
37MP0004233_abnormal_muscle_weight1.35391620
38MP0002452_abnormal_antigen_presenting1.31187573
39MP0005248_abnormal_Harderian_gland1.27610722
40MP0001919_abnormal_reproductive_system1.26925338
41MP0010386_abnormal_urinary_bladder1.26494846
42MP0005058_abnormal_lysosome_morphology1.24475500
43MP0002998_abnormal_bone_remodeling1.23031701
44MP0000678_abnormal_parathyroid_gland1.22569364
45MP0001765_abnormal_ion_homeostasis1.21922167
46MP0002127_abnormal_cardiovascular_syste1.20721695
47MP0005451_abnormal_body_composition1.11813300
48MP0002166_altered_tumor_susceptibility1.10000741
49MP0005409_darkened_coat_color1.07625517
50MP0000716_abnormal_immune_system1.06745706
51MP0004264_abnormal_extraembryonic_tissu1.06745422
52MP0002405_respiratory_system_inflammati1.04734748
53MP0004883_abnormal_blood_vessel1.00920695
54MP0000703_abnormal_thymus_morphology0.99396624
55MP0001905_abnormal_dopamine_level0.97104024
56MP0002398_abnormal_bone_marrow0.96608387
57MP0008995_early_reproductive_senescence0.96280015
58MP0005166_decreased_susceptibility_to0.95826103
59MP0000470_abnormal_stomach_morphology0.95370990
60MP0004484_altered_response_of0.93610203
61MP0001533_abnormal_skeleton_physiology0.92826599
62MP0009764_decreased_sensitivity_to0.92693119
63MP0002138_abnormal_hepatobiliary_system0.91556086
64MP0003136_yellow_coat_color0.91422026
65MP0002009_preneoplasia0.90722973
66MP0009697_abnormal_copulation0.90649078
67MP0000685_abnormal_immune_system0.90256277
68MP0001845_abnormal_inflammatory_respons0.88808681
69MP0002722_abnormal_immune_system0.88673301
70MP0001984_abnormal_olfaction0.86800875
71MP0002933_joint_inflammation0.86038876
72MP0002277_abnormal_respiratory_mucosa0.85764551
73MP0001486_abnormal_startle_reflex0.83158551
74MP0005646_abnormal_pituitary_gland0.82810097
75MP0005647_abnormal_sex_gland0.82338418
76MP0001485_abnormal_pinna_reflex0.82298222
77MP0002249_abnormal_larynx_morphology0.81277161
78MP0003115_abnormal_respiratory_system0.80171550
79MP0004084_abnormal_cardiac_muscle0.79648504
80MP0005389_reproductive_system_phenotype0.77886259
81MP0002148_abnormal_hypersensitivity_rea0.77085425
82MP0009046_muscle_twitch0.76321224
83MP0003878_abnormal_ear_physiology0.75803533
84MP0005377_hearing/vestibular/ear_phenot0.75803533
85MP0001986_abnormal_taste_sensitivity0.74689866
86MP0001790_abnormal_immune_system0.74671165
87MP0005387_immune_system_phenotype0.74671165
88MP0005666_abnormal_adipose_tissue0.73470093
89MP0006072_abnormal_retinal_apoptosis0.72841809
90MP0005167_abnormal_blood-brain_barrier0.70235187
91MP0001348_abnormal_lacrimal_gland0.69503320
92MP0005164_abnormal_response_to0.68949321
93MP0008872_abnormal_physiological_respon0.68732644
94MP0003191_abnormal_cellular_cholesterol0.68654098
95MP0004885_abnormal_endolymph0.67736372
96MP0000230_abnormal_systemic_arterial0.67236855
97MP0003011_delayed_dark_adaptation0.67076274
98MP0005636_abnormal_mineral_homeostasis0.66332555
99MP0005310_abnormal_salivary_gland0.66122015
100MP0000538_abnormal_urinary_bladder0.66104497
101MP0002429_abnormal_blood_cell0.64845997
102MP0000681_abnormal_thyroid_gland0.64734670
103MP0008058_abnormal_DNA_repair0.64388343
104MP0010155_abnormal_intestine_physiology0.64103001
105MP0005423_abnormal_somatic_nervous0.62500830
106MP0002234_abnormal_pharynx_morphology0.58927689
107MP0000569_abnormal_digit_pigmentation0.56216333
108MP0005397_hematopoietic_system_phenotyp0.52361478
109MP0001545_abnormal_hematopoietic_system0.52361478
110MP0001764_abnormal_homeostasis0.51040618
111MP0003950_abnormal_plasma_membrane0.50080435
112MP0000358_abnormal_cell_content/0.48152010
113MP0003329_amyloid_beta_deposits0.47936879
114MP0001293_anophthalmia0.47464873
115MP0009278_abnormal_bone_marrow0.46477433
116MP0000534_abnormal_ureter_morphology0.45666992
117MP0000751_myopathy0.45199033
118MP0001324_abnormal_eye_pigmentation0.45145013
119MP0003699_abnormal_female_reproductive0.45098987
120MP0004036_abnormal_muscle_relaxation0.44815246
121MP0010094_abnormal_chromosome_stability0.38547845
122MP0000462_abnormal_digestive_system0.37015920
123MP0009115_abnormal_fat_cell0.36923534
124MP0005253_abnormal_eye_physiology0.35980989
125MP0005503_abnormal_tendon_morphology0.35074037
126MP0005551_abnormal_eye_electrophysiolog0.34563895
127MP0002971_abnormal_brown_adipose0.34238418
128MP0008961_abnormal_basal_metabolism0.33985143
129MP0002269_muscular_atrophy0.33816435
130MP0002736_abnormal_nociception_after0.33745503
131MP0004742_abnormal_vestibular_system0.33727377
132MP0004019_abnormal_vitamin_homeostasis0.33568814
133MP0003942_abnormal_urinary_system0.33171124
134MP0002928_abnormal_bile_duct0.32577840
135MP0003879_abnormal_hair_cell0.32390067
136MP0002295_abnormal_pulmonary_circulatio0.30538415
137MP0005391_vision/eye_phenotype0.30167969
138MP0004134_abnormal_chest_morphology0.28983144
139MP0005375_adipose_tissue_phenotype0.28827467
140MP0001849_ear_inflammation0.26849728
141MP0002796_impaired_skin_barrier0.24555506
142MP0003948_abnormal_gas_homeostasis0.23054574
143MP0003786_premature_aging0.22751705
144MP0002108_abnormal_muscle_morphology0.22637455
145MP0001270_distended_abdomen0.22190848
146MP0003861_abnormal_nervous_system0.22144381
147MP0001119_abnormal_female_reproductive0.22066160
148MP0004270_analgesia0.21525063
149MP0004811_abnormal_neuron_physiology0.20789539
150MP0003111_abnormal_nucleus_morphology0.20692491
151MP0001661_extended_life_span0.20570760
152MP0003045_fibrosis0.20071406
153MP0003633_abnormal_nervous_system0.19671511
154MP0001730_embryonic_growth_arrest0.19618142
155MP0000604_amyloidosis0.19433249
156MP0009250_abnormal_appendicular_skeleto0.19217750
157MP0002152_abnormal_brain_morphology0.18840499
158MP0002092_abnormal_eye_morphology0.18833167
159MP0001727_abnormal_embryo_implantation0.18653422
160MP0005257_abnormal_intraocular_pressure0.17626240
161MP0006036_abnormal_mitochondrial_physio0.17493180
162MP0001968_abnormal_touch/_nociception0.17116296
163MP0002169_no_abnormal_phenotype0.16985575
164MP0002873_normal_phenotype0.16721418
165MP0002909_abnormal_adrenal_gland0.16276917
166MP0004130_abnormal_muscle_cell0.15948902
167MP0003959_abnormal_lean_body0.15816981
168MP0002109_abnormal_limb_morphology0.15286971
169MP0003936_abnormal_reproductive_system0.15238428
170MP0008007_abnormal_cellular_replicative0.14915637
171MP0003631_nervous_system_phenotype0.13640801
172MP0002102_abnormal_ear_morphology0.13613980
173MP0002118_abnormal_lipid_homeostasis0.13268527
174MP0008569_lethality_at_weaning0.12831188
175MP0004043_abnormal_pH_regulation0.12476790

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.31731205
2Abnormal respiratory epithelium morphology (HP:0012253)9.31731205
3Abnormal respiratory motile cilium physiology (HP:0012261)9.10121153
4Rhinitis (HP:0012384)7.40968690
5Abnormal ciliary motility (HP:0012262)7.22837020
6Infertility (HP:0000789)7.02553798
7Chronic bronchitis (HP:0004469)6.91933072
8Nasal polyposis (HP:0100582)6.21866147
9Resting tremor (HP:0002322)5.85344165
10Male infertility (HP:0003251)5.20696685
11Abnormality of the nasal mucosa (HP:0000433)5.09589383
12Stomach cancer (HP:0012126)4.77754175
13Abnormality of the columella (HP:0009929)4.72794561
14Bronchitis (HP:0012387)4.53362675
15Sex reversal (HP:0012245)4.44152506
16Abnormal sex determination (HP:0012244)4.44152506
17Bronchiectasis (HP:0002110)4.37191668
18Nephronophthisis (HP:0000090)4.20959365
19Reduced antithrombin III activity (HP:0001976)3.92204244
20Autoimmune thrombocytopenia (HP:0001973)3.88738454
21Abnormal spermatogenesis (HP:0008669)3.78240422
22Colitis (HP:0002583)3.78214693
23Postural instability (HP:0002172)3.77404614
24Eosinophilia (HP:0001880)3.72592334
25Ventricular fibrillation (HP:0001663)3.69929069
26Hypoplasia of the uterus (HP:0000013)3.59762776
27Absent rod-and cone-mediated responses on ERG (HP:0007688)3.57147555
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.51804494
29Optic neuritis (HP:0100653)3.41540857
30Retrobulbar optic neuritis (HP:0100654)3.41540857
31Granulocytopenia (HP:0001913)3.31806171
32Autoimmune hemolytic anemia (HP:0001890)3.31016959
33Severe visual impairment (HP:0001141)3.29605777
34Inflammation of the large intestine (HP:0002037)3.29431218
35Recurrent sinusitis (HP:0011108)3.28903602
36Recurrent otitis media (HP:0000403)3.28878623
37Abnormality of the renal medulla (HP:0100957)3.23024369
38Orchitis (HP:0100796)3.19549274
39Attenuation of retinal blood vessels (HP:0007843)3.16353501
40Abnormality of B cell number (HP:0010975)3.07755282
41Abnormal rod and cone electroretinograms (HP:0008323)3.07471573
42Myositis (HP:0100614)3.06047334
43Gastrointestinal inflammation (HP:0004386)2.97281541
44Recurrent bronchitis (HP:0002837)2.94315744
45Tubulointerstitial nephritis (HP:0001970)2.94157206
46Gonadal dysgenesis (HP:0000133)2.93012374
47Impulsivity (HP:0100710)2.91709626
48Abnormality of T cell number (HP:0011839)2.90084576
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.89507898
50Abnormality of eosinophils (HP:0001879)2.87481811
51Gastrointestinal infarctions (HP:0005244)2.80716533
52Eczematoid dermatitis (HP:0000976)2.78229583
53Male pseudohermaphroditism (HP:0000037)2.76316559
54Aplasia/hypoplasia of the uterus (HP:0008684)2.67570772
55Thoracolumbar scoliosis (HP:0002944)2.64004977
56Tubular atrophy (HP:0000092)2.59537961
57Leukocytosis (HP:0001974)2.58775363
58Hypochromic anemia (HP:0001931)2.55105987
59Gonadotropin excess (HP:0000837)2.53659659
60Abnormal gallbladder physiology (HP:0012438)2.52955557
61Cholecystitis (HP:0001082)2.52955557
62Congenital sensorineural hearing impairment (HP:0008527)2.49795825
63Tubulointerstitial abnormality (HP:0001969)2.45547899
64Atonic seizures (HP:0010819)2.43681621
65Keratoconjunctivitis sicca (HP:0001097)2.42786028
66Increased IgM level (HP:0003496)2.42226510
67Congenital stationary night blindness (HP:0007642)2.40263012
68Abnormality of midbrain morphology (HP:0002418)2.39597009
69Molar tooth sign on MRI (HP:0002419)2.39597009
70Retinal atrophy (HP:0001105)2.37494348
71Keratoconjunctivitis (HP:0001096)2.33833391
72Vasculitis (HP:0002633)2.33102961
73Bony spicule pigmentary retinopathy (HP:0007737)2.32645068
74Thoracic kyphosis (HP:0002942)2.28145044
75Self-mutilation (HP:0000742)2.26364325
76Germ cell neoplasia (HP:0100728)2.25025598
77Azoospermia (HP:0000027)2.23729709
78Abnormality of the frontal sinuses (HP:0002687)2.23142747
79Sensory axonal neuropathy (HP:0003390)2.16910484
80Dyschromatopsia (HP:0007641)2.16786543
81Obstructive lung disease (HP:0006536)2.16544534
82Chronic obstructive pulmonary disease (HP:0006510)2.16544534
83Recurrent abscess formation (HP:0002722)2.14457184
84Recurrent bacterial skin infections (HP:0005406)2.13507801
85Cone-rod dystrophy (HP:0000548)2.09994814
86Abnormality of T cell physiology (HP:0011840)2.09672266
87Abnormality of T cells (HP:0002843)2.07909470
88Facial hemangioma (HP:0000329)2.07317678
89Recurrent fungal infections (HP:0002841)2.06150640
90Medial flaring of the eyebrow (HP:0010747)2.05679913
91Spastic tetraparesis (HP:0001285)2.05613153
92Choroideremia (HP:0001139)2.02834420
93Polyneuropathy (HP:0001271)2.00181810
94Dynein arm defect of respiratory motile cilia (HP:0012255)13.6786951
95Absent/shortened dynein arms (HP:0200106)13.6786951
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7469772
97Tubulointerstitial fibrosis (HP:0005576)1.98207786
98Abnormality of the intrinsic pathway (HP:0010989)1.97628931
99Stomatitis (HP:0010280)1.95238859
100Tetany (HP:0001281)1.95229850
101Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93658505
102Facial diplegia (HP:0001349)1.90933437
103Metabolic alkalosis (HP:0200114)1.90464321
104Heterotopia (HP:0002282)1.90136502
105Bell-shaped thorax (HP:0001591)1.88632589
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87360998
107Decreased central vision (HP:0007663)1.85744411
108Hematochezia (HP:0002573)1.85237773
109Arterial thrombosis (HP:0004420)1.84533673
110Elevated erythrocyte sedimentation rate (HP:0003565)1.82995451
111Short ribs (HP:0000773)1.82754636
112Photophobia (HP:0000613)1.81828619
113Abnormality of macrophages (HP:0004311)1.81755012
114Amyloidosis (HP:0011034)1.81153588
115Abnormality of male internal genitalia (HP:0000022)1.78947461
116Stage 5 chronic kidney disease (HP:0003774)1.78888219
117Recurrent gram-negative bacterial infections (HP:0005420)1.77660439
118Retinal dysplasia (HP:0007973)1.75860172
119Meningitis (HP:0001287)1.75627554
120Postaxial foot polydactyly (HP:0001830)1.74093772
121Hemoptysis (HP:0002105)1.73992412
122Increased IgE level (HP:0003212)1.73407354
123Protruding tongue (HP:0010808)1.73198157
124Macular degeneration (HP:0000608)1.73011566
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72984644
126Absent epiphyses (HP:0010577)1.72984644
127Hemorrhage of the eye (HP:0011885)1.72785768
128Polyuria (HP:0000103)1.72123316
129Polydipsia (HP:0001959)1.71406860
130Abnormal drinking behavior (HP:0030082)1.71406860
131Abnormality of the renal cortex (HP:0011035)1.66838296
132Short femoral neck (HP:0100864)1.66463370
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63853509
134Abnormality of renal excretion (HP:0011036)1.63359838
135Neurofibrillary tangles (HP:0002185)1.61835031
136Abnormal biliary tract physiology (HP:0012439)1.58883675
137Bile duct proliferation (HP:0001408)1.58883675
138Fibular hypoplasia (HP:0003038)1.58863170
139Abnormality of dentin (HP:0010299)1.58687300
140Absent frontal sinuses (HP:0002688)1.56995682
141Congenital hepatic fibrosis (HP:0002612)1.53464180
142Asymmetric septal hypertrophy (HP:0001670)1.52029113
143Abnormality of the lower motor neuron (HP:0002366)1.51700926
144Abnormality of permanent molar morphology (HP:0011071)1.50220578
145Abnormality of the dental root (HP:0006486)1.50220578
146Taurodontia (HP:0000679)1.50220578
147Oculomotor apraxia (HP:0000657)1.48600620
148Deformed sella turcica (HP:0002681)1.44513579
149Hemiparesis (HP:0001269)1.44157461
150Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.43555881
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.42307287
152J-shaped sella turcica (HP:0002680)1.40252805
153Abnormality of the dental pulp (HP:0006479)1.39692662
154Abnormality of molar morphology (HP:0011070)1.39080359
155Abnormality of molar (HP:0011077)1.39080359
156Short thorax (HP:0010306)1.37877300
157Renal dysplasia (HP:0000110)1.37609914
158Abnormal urine output (HP:0012590)1.34715045
159Cerebral inclusion bodies (HP:0100314)1.34531703
160Microglossia (HP:0000171)1.33815860
161Broad distal phalanx of finger (HP:0009836)1.29839840
162Postaxial hand polydactyly (HP:0001162)1.29600957
163Amyotrophic lateral sclerosis (HP:0007354)1.29400635
164Truncal obesity (HP:0001956)1.26507369
165Aplasia/Hypoplasia of the lens (HP:0008063)1.26278641
166Glucose intolerance (HP:0000833)1.24675617
167Facial cleft (HP:0002006)1.23618464
168Flattened epiphyses (HP:0003071)1.22102181
169Double outlet right ventricle (HP:0001719)1.19908971
170Congenital malformation of the right heart (HP:0011723)1.19908971
171Short nail (HP:0001799)1.19756811
172Bundle branch block (HP:0011710)1.19599441
173Cerebellar dysplasia (HP:0007033)1.18906434
174Hypercholesterolemia (HP:0003124)1.18558930
175Exercise-induced myalgia (HP:0003738)1.16230543
176Nephropathy (HP:0000112)1.15712512
177Abnormality of the sella turcica (HP:0002679)1.14578560
178Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.14416645
179Cystic liver disease (HP:0006706)1.13851118
180Impaired proprioception (HP:0010831)1.13058481
181Small epiphyses (HP:0010585)1.12453176
182Chronic sinusitis (HP:0011109)1.11975475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.76332559
2PDK47.76332559
3TESK16.44171164
4PRKD35.73095599
5PDK25.13318334
6ICK4.85777705
7MARK34.70759972
8PNCK2.53371439
9MYLK2.36380306
10PTK2B2.34718050
11TLK12.29545702
12WNK42.21240307
13STK392.14593846
14FRK2.06056659
15ZAK2.05089570
16GRK62.00531225
17STK381.80692860
18RPS6KA51.77556188
19IRAK41.70895795
20DYRK1B1.63826481
21NEK21.57003268
22LATS11.53021835
23BLK1.47422062
24TAOK31.33545076
25FES1.15082945
26MAP3K31.13180495
27SGK2231.10781705
28SGK4941.10781705
29PDK11.09626069
30BTK1.08649715
31TNK21.08298679
32CDK31.06216621
33INSRR1.01606168
34TYRO30.99758321
35PIK3CG0.97399821
36HCK0.97293122
37CAMKK20.96780123
38MAP4K10.91211238
39MAP3K110.91050052
40MAPK150.90508184
41ZAP700.90381995
42CAMK10.88676017
43WNK10.86647525
44CAMK1G0.86066783
45CSK0.84696709
46MAP2K70.81929211
47LMTK20.80418404
48DYRK30.75904800
49KSR20.74402378
50MAP2K30.73849075
51MAP3K130.71992927
52CCNB10.69488262
53SYK0.68455063
54OBSCN0.67414489
55PDPK10.66100444
56PASK0.65141999
57MAP2K60.64942069
58STK30.63644035
59IRAK10.62876198
60FGR0.62036589
61TXK0.61759313
62EEF2K0.60806878
63RIPK40.60528608
64JAK30.60177333
65JAK20.59835237
66SGK20.59478896
67CAMK40.59437318
68SIK20.58763404
69MATK0.57601286
70NLK0.55800830
71TTK0.54976950
72MAP3K50.54647519
73TESK20.54181806
74CHEK20.52938182
75CDC42BPA0.52107648
76SGK30.51312994
77TAOK20.49132323
78KIT0.47698016
79MAP3K90.47651784
80JAK10.47288350
81MAP2K20.46392415
82MAP3K20.45960850
83RPS6KA40.45090761
84MST1R0.44751994
85PAK10.44059532
86ITK0.42061145
87RET0.42059291
88ADRBK20.41761317
89NTRK20.41716667
90PIK3CA0.40944904
91STK38L0.40708199
92LYN0.40533303
93TYK20.40244800
94PAK20.39554427
95CSNK1A1L0.38240118
96PINK10.37993135
97PLK20.37032461
98CHEK10.36876086
99GRK10.35781415
100ROCK10.35624980
101MAPK120.35353167
102NEK60.33863575
103KDR0.33374984
104PRKCG0.33193535
105MTOR0.32780977
106IRAK20.31979001
107MARK20.31873873
108PKN20.31256442
109PRKAA20.29769442
110IKBKE0.29600135
111PAK40.29547612
112ATM0.27366486
113LCK0.27108228
114PRKG20.25870502
115NTRK30.24537389
116MUSK0.23966601
117CAMKK10.23934408
118RPS6KA20.23184783
119PRKAA10.21801751
120WEE10.20727956
121MAP3K100.19780723
122ATR0.17579229
123MAPKAPK50.16890918
124CDK60.16073445
125RPS6KB10.14322879
126PRKCZ0.12544982
127PRKCQ0.11283859
128EPHB10.09864508
129DDR20.09319131
130CSNK1D0.08317636
131PLK10.08226842
132PLK40.07828055
133WNK30.06923960
134CDK150.06799939
135GSK3B0.06797823
136PKN10.05864417
137RPS6KA10.05361364
138PRKG10.05273641
139CSNK2A10.05048769
140BMPR1B0.04534974
141CDK180.04299690
142CDK11A0.03739034
143CDK40.03497982
144CAMK2A0.03214949
145PRKCD0.03177295
146TAOK10.03107886
147PRKCB0.02332777
148PRKACG0.02247880
149CDK20.02234782
150CDK10.01974694
151CLK10.01650322
152CDC70.01506580
153STK110.01388505
154CSNK2A20.01362992
155MAPK80.01156163
156EGFR0.01073000
157CDK140.00698881
158MAP3K10.00490904
159PRKCA0.00447724
160PDGFRB0.00386295
161MAPK1-0.0359781
162BRSK1-0.0344101
163RPS6KA3-0.0280069
164PRKACA-0.0204430
165CSF1R-0.0188765
166BRSK2-0.0151729
167PRKACB-0.0142280
168CDK12-0.0102944
169SRC-0.0094867
170PAK6-0.0008260
171PRKDC-0.0003149

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.99083940
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051304.55573235
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.46969758
4Pyruvate metabolism_Homo sapiens_hsa006203.49366692
5Olfactory transduction_Homo sapiens_hsa047403.22966059
6Vitamin B6 metabolism_Homo sapiens_hsa007503.12171955
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95266583
8Linoleic acid metabolism_Homo sapiens_hsa005912.84450784
9Gap junction_Homo sapiens_hsa045402.82019107
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74190748
11Nitrogen metabolism_Homo sapiens_hsa009102.67637065
12Propanoate metabolism_Homo sapiens_hsa006402.67233532
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63746430
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.58595725
15Glucagon signaling pathway_Homo sapiens_hsa049222.57336584
16Apoptosis_Homo sapiens_hsa042102.41591738
17Phagosome_Homo sapiens_hsa041452.28236685
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12570663
19PPAR signaling pathway_Homo sapiens_hsa033202.00013411
20Glycerolipid metabolism_Homo sapiens_hsa005611.98628063
21Dorso-ventral axis formation_Homo sapiens_hsa043201.94499855
22Selenocompound metabolism_Homo sapiens_hsa004501.93066505
23Basal transcription factors_Homo sapiens_hsa030221.85342845
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.73857717
25Primary immunodeficiency_Homo sapiens_hsa053401.65899951
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.62889138
27Fructose and mannose metabolism_Homo sapiens_hsa000511.62538148
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61781680
29Oocyte meiosis_Homo sapiens_hsa041141.60980350
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58577988
31B cell receptor signaling pathway_Homo sapiens_hsa046621.56752782
32Amphetamine addiction_Homo sapiens_hsa050311.54601657
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.53835432
34Fatty acid metabolism_Homo sapiens_hsa012121.52601118
35Mineral absorption_Homo sapiens_hsa049781.50464414
36T cell receptor signaling pathway_Homo sapiens_hsa046601.48055864
37Fatty acid degradation_Homo sapiens_hsa000711.46532415
38Osteoclast differentiation_Homo sapiens_hsa043801.43833977
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.38436434
40Ether lipid metabolism_Homo sapiens_hsa005651.38316183
41Cardiac muscle contraction_Homo sapiens_hsa042601.37726374
42Pentose phosphate pathway_Homo sapiens_hsa000301.31957349
43Graft-versus-host disease_Homo sapiens_hsa053321.31666544
44Carbon metabolism_Homo sapiens_hsa012001.28168888
45Fat digestion and absorption_Homo sapiens_hsa049751.27729100
46Malaria_Homo sapiens_hsa051441.27682561
47Renin secretion_Homo sapiens_hsa049241.19745281
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.18948299
49Huntingtons disease_Homo sapiens_hsa050161.17803520
50Allograft rejection_Homo sapiens_hsa053301.17173604
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.16433037
52Arginine biosynthesis_Homo sapiens_hsa002201.16181201
53Autoimmune thyroid disease_Homo sapiens_hsa053201.14979919
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13735090
55Hematopoietic cell lineage_Homo sapiens_hsa046401.12785107
56Tuberculosis_Homo sapiens_hsa051521.12349598
57Fanconi anemia pathway_Homo sapiens_hsa034601.09049403
58Antigen processing and presentation_Homo sapiens_hsa046121.08485687
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06150235
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.04591147
61Oxytocin signaling pathway_Homo sapiens_hsa049211.04429462
62Butanoate metabolism_Homo sapiens_hsa006501.03910608
63Leishmaniasis_Homo sapiens_hsa051401.03061220
64Hedgehog signaling pathway_Homo sapiens_hsa043401.01581003
65Staphylococcus aureus infection_Homo sapiens_hsa051500.99549188
66Purine metabolism_Homo sapiens_hsa002300.99179195
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98636728
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.96783223
69mRNA surveillance pathway_Homo sapiens_hsa030150.94871011
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92472238
71Measles_Homo sapiens_hsa051620.91826872
72RNA transport_Homo sapiens_hsa030130.90147575
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89251090
74Type I diabetes mellitus_Homo sapiens_hsa049400.88835357
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88136514
76Collecting duct acid secretion_Homo sapiens_hsa049660.86665429
77TNF signaling pathway_Homo sapiens_hsa046680.85611128
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85559120
79Protein digestion and absorption_Homo sapiens_hsa049740.85289331
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84554262
81Insulin secretion_Homo sapiens_hsa049110.84153467
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.84074819
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82700557
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80876374
85Acute myeloid leukemia_Homo sapiens_hsa052210.80562717
86Glutathione metabolism_Homo sapiens_hsa004800.80363372
87Arachidonic acid metabolism_Homo sapiens_hsa005900.80185765
88Thyroid hormone synthesis_Homo sapiens_hsa049180.79464015
89Estrogen signaling pathway_Homo sapiens_hsa049150.79142901
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79101987
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76983026
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76405703
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76395063
94Chemokine signaling pathway_Homo sapiens_hsa040620.76369179
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75783965
96Influenza A_Homo sapiens_hsa051640.74860344
97Bile secretion_Homo sapiens_hsa049760.73739315
98Long-term potentiation_Homo sapiens_hsa047200.73066306
99Biosynthesis of amino acids_Homo sapiens_hsa012300.72120476
100Salivary secretion_Homo sapiens_hsa049700.70600482
101Herpes simplex infection_Homo sapiens_hsa051680.69639405
102Platelet activation_Homo sapiens_hsa046110.68171861
103MAPK signaling pathway_Homo sapiens_hsa040100.67153201
104Phenylalanine metabolism_Homo sapiens_hsa003600.66475455
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66469011
106Chemical carcinogenesis_Homo sapiens_hsa052040.65077540
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63379040
108Taste transduction_Homo sapiens_hsa047420.62759679
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61847275
110Legionellosis_Homo sapiens_hsa051340.60926336
111African trypanosomiasis_Homo sapiens_hsa051430.60705649
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59917537
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59873334
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59871947
115Hepatitis B_Homo sapiens_hsa051610.58696663
116Calcium signaling pathway_Homo sapiens_hsa040200.58162205
117Pancreatic secretion_Homo sapiens_hsa049720.56601945
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55992206
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.55711537
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55173810
121Gastric acid secretion_Homo sapiens_hsa049710.55005153
122Viral carcinogenesis_Homo sapiens_hsa052030.54210538
123Choline metabolism in cancer_Homo sapiens_hsa052310.53933994
124Type II diabetes mellitus_Homo sapiens_hsa049300.53460041
125Viral myocarditis_Homo sapiens_hsa054160.51746887
126FoxO signaling pathway_Homo sapiens_hsa040680.51327202
127ABC transporters_Homo sapiens_hsa020100.50902463
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.46302784
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.45439635
130AMPK signaling pathway_Homo sapiens_hsa041520.45107901
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44651720
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44077003
133Cholinergic synapse_Homo sapiens_hsa047250.43931230
134Endocytosis_Homo sapiens_hsa041440.41492830
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39681259
136VEGF signaling pathway_Homo sapiens_hsa043700.39074018
137Phototransduction_Homo sapiens_hsa047440.38966631
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38048944
139Renin-angiotensin system_Homo sapiens_hsa046140.37661290
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37199154
141Synaptic vesicle cycle_Homo sapiens_hsa047210.37074374
142Endometrial cancer_Homo sapiens_hsa052130.36044079
143cAMP signaling pathway_Homo sapiens_hsa040240.35986490
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35608450
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34849339
146Circadian entrainment_Homo sapiens_hsa047130.34413972
147Metabolic pathways_Homo sapiens_hsa011000.34095292
148Inositol phosphate metabolism_Homo sapiens_hsa005620.32956049
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27980000
150Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26978750
151Cocaine addiction_Homo sapiens_hsa050300.24096222
152Systemic lupus erythematosus_Homo sapiens_hsa053220.24002766
153Basal cell carcinoma_Homo sapiens_hsa052170.23766897
154Sulfur metabolism_Homo sapiens_hsa009200.20710601
155Sphingolipid metabolism_Homo sapiens_hsa006000.19021778
156Pyrimidine metabolism_Homo sapiens_hsa002400.17524220
157N-Glycan biosynthesis_Homo sapiens_hsa005100.16600348
158Alcoholism_Homo sapiens_hsa050340.13426414
159Wnt signaling pathway_Homo sapiens_hsa043100.12975896
160HIF-1 signaling pathway_Homo sapiens_hsa040660.11326022
161Glutamatergic synapse_Homo sapiens_hsa047240.11073531
162Retinol metabolism_Homo sapiens_hsa008300.10093256
163Other glycan degradation_Homo sapiens_hsa005110.09608901

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