ANTXRLP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mast cell activation involved in immune response (GO:0002279)6.66857141
2mast cell degranulation (GO:0043303)6.66857141
3regulation of autophagic vacuole assembly (GO:2000785)6.63195331
4cellular response to interleukin-15 (GO:0071350)6.25994028
5mast cell activation (GO:0045576)6.02896464
6positive regulation of granulocyte differentiation (GO:0030854)5.96772430
7negative regulation of T cell apoptotic process (GO:0070233)5.70055720
8regulation of vacuole organization (GO:0044088)5.65107381
9negative T cell selection (GO:0043383)5.57167234
10response to interleukin-15 (GO:0070672)5.33343901
11histone H3-K36 demethylation (GO:0070544)5.28359928
12positive regulation of gamma-delta T cell activation (GO:0046645)5.27982116
13negative regulation of bone resorption (GO:0045779)5.26236592
14V(D)J recombination (GO:0033151)5.24783132
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.02211231
16negative thymic T cell selection (GO:0045060)4.98166449
17radial glial cell differentiation (GO:0060019)4.91183650
18regulation of granulocyte differentiation (GO:0030852)4.85636712
19thymic T cell selection (GO:0045061)4.73666196
20regulation of gamma-delta T cell differentiation (GO:0045586)4.71593916
21regulation of receptor binding (GO:1900120)4.70116729
22cellular response to lithium ion (GO:0071285)4.66163477
23positive T cell selection (GO:0043368)4.58669930
24CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.58471735
25T-helper cell differentiation (GO:0042093)4.58471735
26T cell selection (GO:0045058)4.52393863
27regulation of B cell receptor signaling pathway (GO:0050855)4.26364933
28activated T cell proliferation (GO:0050798)4.25865474
29tongue development (GO:0043586)4.22880762
30negative regulation of bone remodeling (GO:0046851)4.12523165
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10227679
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.09821386
33regulation of gamma-delta T cell activation (GO:0046643)4.09723573
34C21-steroid hormone biosynthetic process (GO:0006700)4.04854722
35alpha-beta T cell activation involved in immune response (GO:0002287)4.02590481
36T cell differentiation involved in immune response (GO:0002292)4.02590481
37alpha-beta T cell differentiation involved in immune response (GO:0002293)4.02590481
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01422618
39regulation of interleukin-4 production (GO:0032673)3.94663167
40T cell migration (GO:0072678)3.93413469
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90452671
42positive thymic T cell selection (GO:0045059)3.89981499
43negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.83622595
44B cell receptor signaling pathway (GO:0050853)3.79662800
45T cell receptor signaling pathway (GO:0050852)3.79535637
46tolerance induction (GO:0002507)3.77143828
47regulation of cellular extravasation (GO:0002691)3.73484822
48regulation of ARF GTPase activity (GO:0032312)3.71341903
49CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.71065733
50negative regulation of thymocyte apoptotic process (GO:0070244)3.67584070
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.65046856
52lymphocyte homeostasis (GO:0002260)3.62977367
53antigen receptor-mediated signaling pathway (GO:0050851)3.61891424
54alpha-beta T cell differentiation (GO:0046632)3.61530092
55negative regulation of phagocytosis (GO:0050765)3.60293083
56regulation of B cell differentiation (GO:0045577)3.60255889
57positive regulation of macrophage differentiation (GO:0045651)3.56972714
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56911420
59negative regulation of cell killing (GO:0031342)3.56911420
60motile cilium assembly (GO:0044458)3.56283587
61antigen processing and presentation of endogenous antigen (GO:0019883)3.55122919
62negative regulation of lymphocyte apoptotic process (GO:0070229)3.51497063
63patterning of blood vessels (GO:0001569)3.51187271
64leukocyte degranulation (GO:0043299)3.48830286
65positive regulation by host of viral transcription (GO:0043923)3.43934022
66regulation of interleukin-13 production (GO:0032656)3.37694571
67positive regulation of B cell proliferation (GO:0030890)3.35009033
68negative regulation of tissue remodeling (GO:0034104)3.33751304
69regulation of T cell apoptotic process (GO:0070232)3.32494111
70detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.30737850
71CD4-positive, alpha-beta T cell activation (GO:0035710)3.28200823
72T cell differentiation (GO:0030217)3.26647433
73leukocyte homeostasis (GO:0001776)3.26557611
74regulation of T cell chemotaxis (GO:0010819)3.26023686
75positive regulation of T cell chemotaxis (GO:0010820)3.26023686
76omega-hydroxylase P450 pathway (GO:0097267)3.25344958
77T cell homeostasis (GO:0043029)3.24959127
78negative regulation of macroautophagy (GO:0016242)3.23272978
79positive regulation of B cell differentiation (GO:0045579)3.19788739
80positive regulation of T cell migration (GO:2000406)3.19653450
81positive regulation of tolerance induction (GO:0002645)3.18961354
82regulation of macrophage differentiation (GO:0045649)3.16770969
83lysosome localization (GO:0032418)3.16172229
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.14915671
85hypothalamus development (GO:0021854)3.14858545
86regulation of interleukin-5 production (GO:0032674)3.14474482
87lymph node development (GO:0048535)3.12783345
88alpha-beta T cell activation (GO:0046631)3.10646132
89regulation of phosphoprotein phosphatase activity (GO:0043666)3.09719958
90positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09638391
91negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.08624667
92regulation of T cell mediated cytotoxicity (GO:0001914)3.08492813
93regulation of fibroblast apoptotic process (GO:2000269)3.04864769
94B cell proliferation (GO:0042100)3.01213788
95negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.99036828
96regulation of T cell tolerance induction (GO:0002664)2.97391790
97negative regulation of organelle assembly (GO:1902116)2.95984070
98negative regulation of granulocyte differentiation (GO:0030853)2.94604530
99negative regulation of necroptotic process (GO:0060546)2.94227596
100cellular response to epinephrine stimulus (GO:0071872)2.93457810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.96013615
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human5.93133608
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.67482919
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.81953368
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.27431752
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03149637
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.79338866
8RUNX_20019798_ChIP-Seq_JUKART_Human3.53717949
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44338068
10MYB_26560356_Chip-Seq_TH2_Human3.09159499
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.91240737
12IGF1R_20145208_ChIP-Seq_DFB_Human2.70901074
13GATA3_27048872_Chip-Seq_THYMUS_Human2.56824394
14AR_21572438_ChIP-Seq_LNCaP_Human2.56710029
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.50414021
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.48936023
17MYB_26560356_Chip-Seq_TH1_Human2.46448933
18SCL_19346495_ChIP-Seq_HPC-7_Human2.31580566
19UTX_26944678_Chip-Seq_JUKART_Human2.31063278
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29806099
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17932632
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10443475
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.09642978
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04626450
25MAF_26560356_Chip-Seq_TH1_Human2.00571508
26MAF_26560356_Chip-Seq_TH2_Human1.96826058
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93841010
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.82285090
29GATA3_26560356_Chip-Seq_TH2_Human1.76891230
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74759963
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71502668
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70526789
33MYC_22102868_ChIP-Seq_BL_Human1.57443230
34ER_23166858_ChIP-Seq_MCF-7_Human1.54604657
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51344016
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50186508
37SPI1_23127762_ChIP-Seq_K562_Human1.46417006
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35867469
39VDR_24763502_ChIP-Seq_THP-1_Human1.30186049
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.29121189
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.27589953
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27523031
43SPI1_23547873_ChIP-Seq_NB4_Human1.27200520
44KDM2B_26808549_Chip-Seq_DND41_Human1.26899050
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26450018
46VDR_24787735_ChIP-Seq_THP-1_Human1.24995884
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20080305
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17446234
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.17141559
50CIITA_25753668_ChIP-Seq_RAJI_Human1.16043596
51SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13377393
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.11479255
53VDR_21846776_ChIP-Seq_THP-1_Human1.11045977
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10964162
55ZNF274_21170338_ChIP-Seq_K562_Hela1.06028607
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00200940
57RXR_22108803_ChIP-Seq_LS180_Human0.99123775
58RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96496310
59RUNX1_22412390_ChIP-Seq_EML_Mouse0.95225404
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92334345
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91538726
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88754158
63KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81878681
64TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81679724
65CTCF_21964334_ChIP-Seq_BJAB-B_Human0.81093857
66GATA3_26560356_Chip-Seq_TH1_Human0.76743920
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76603853
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76207253
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75726862
70BRD4_27068464_Chip-Seq_AML-cells_Mouse0.74507898
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73966332
72GATA1_22025678_ChIP-Seq_K562_Human0.73328671
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.73223120
74KDM2B_26808549_Chip-Seq_JURKAT_Human0.72700971
75NANOG_20526341_ChIP-Seq_ESCs_Human0.71621124
76CTCF_21964334_Chip-Seq_Bcells_Human0.71040166
77BCAT_22108803_ChIP-Seq_LS180_Human0.70524940
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70476502
79SPI1_20517297_ChIP-Seq_HL60_Human0.69392910
80VDR_23849224_ChIP-Seq_CD4+_Human0.68712347
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68539176
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.68138832
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.67221790
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66366459
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.65403653
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65265872
87FLI1_27457419_Chip-Seq_LIVER_Mouse0.65087506
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64767716
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.64504412
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63424779
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.62965407
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.62417958
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.62213952
94FOXP3_21729870_ChIP-Seq_TREG_Human0.61972908
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.61872171
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.61816221
97BCL6_27268052_Chip-Seq_Bcells_Human0.61463253
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59895241
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.59573028
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.58784795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.11496843
2MP0004381_abnormal_hair_follicle5.06278221
3MP0005671_abnormal_response_to4.01665630
4MP0002166_altered_tumor_susceptibility3.14958774
5MP0001800_abnormal_humoral_immune3.08553503
6MP0001835_abnormal_antigen_presentation3.02371533
7MP0000703_abnormal_thymus_morphology2.91206859
8MP0005075_abnormal_melanosome_morpholog2.88079270
9MP0005000_abnormal_immune_tolerance2.74232213
10MP0002420_abnormal_adaptive_immunity2.56376766
11MP0001819_abnormal_immune_cell2.49620876
12MP0009785_altered_susceptibility_to2.42551352
13MP0002132_abnormal_respiratory_system2.39090164
14MP0002009_preneoplasia2.36390827
15MP0000685_abnormal_immune_system2.28554862
16MP0002398_abnormal_bone_marrow2.27123895
17MP0002723_abnormal_immune_serum2.23946350
18MP0002405_respiratory_system_inflammati2.23482044
19MP0002452_abnormal_antigen_presenting2.19850705
20MP0000465_gastrointestinal_hemorrhage2.17359731
21MP0005025_abnormal_response_to2.14743635
22MP0002722_abnormal_immune_system2.13476141
23MP0000716_abnormal_immune_system2.10954086
24MP0003724_increased_susceptibility_to2.10943172
25MP0009840_abnormal_foam_cell2.08942680
26MP0002148_abnormal_hypersensitivity_rea2.01869586
27MP0002006_tumorigenesis1.99446771
28MP0001790_abnormal_immune_system1.92315010
29MP0005387_immune_system_phenotype1.92315010
30MP0003436_decreased_susceptibility_to1.88109468
31MP0002933_joint_inflammation1.84547611
32MP0008004_abnormal_stomach_pH1.78071517
33MP0000689_abnormal_spleen_morphology1.76347078
34MP0001849_ear_inflammation1.76245021
35MP0003315_abnormal_perineum_morphology1.73912403
36MP0002419_abnormal_innate_immunity1.71621443
37MP0010155_abnormal_intestine_physiology1.55337591
38MP0001845_abnormal_inflammatory_respons1.54075957
39MP0005166_decreased_susceptibility_to1.51759322
40MP0004484_altered_response_of1.48428328
41MP0002429_abnormal_blood_cell1.48371180
42MP0000678_abnormal_parathyroid_gland1.45052402
43MP0004947_skin_inflammation1.44103618
44MP0003828_pulmonary_edema1.43025327
45MP0009333_abnormal_splenocyte_physiolog1.38381389
46MP0006035_abnormal_mitochondrial_morpho1.36719587
47MP0000681_abnormal_thyroid_gland1.32635047
48MP0005464_abnormal_platelet_physiology1.26826706
49MP0005503_abnormal_tendon_morphology1.25553338
50MP0002998_abnormal_bone_remodeling1.22704006
51MP0003866_abnormal_defecation1.18557214
52MP0009697_abnormal_copulation1.11983446
53MP0001919_abnormal_reproductive_system1.11969489
54MP0002102_abnormal_ear_morphology1.11688313
55MP0003136_yellow_coat_color1.05566017
56MP0002138_abnormal_hepatobiliary_system1.04939314
57MP0001853_heart_inflammation1.00725462
58MP0003300_gastrointestinal_ulcer0.99730503
59MP0005174_abnormal_tail_pigmentation0.99361179
60MP0000858_altered_metastatic_potential0.96279426
61MP0001879_abnormal_lymphatic_vessel0.95999513
62MP0001873_stomach_inflammation0.89691160
63MP0001270_distended_abdomen0.89118086
64MP0010094_abnormal_chromosome_stability0.86707507
65MP0002019_abnormal_tumor_incidence0.86400817
66MP0001851_eye_inflammation0.84023122
67MP0001188_hyperpigmentation0.81197792
68MP0004883_abnormal_blood_vessel0.81003965
69MP0002876_abnormal_thyroid_physiology0.80283823
70MP0002160_abnormal_reproductive_system0.79665926
71MP0009278_abnormal_bone_marrow0.78340355
72MP0002693_abnormal_pancreas_physiology0.77994044
73MP0006036_abnormal_mitochondrial_physio0.77040473
74MP0001544_abnormal_cardiovascular_syste0.76215375
75MP0005385_cardiovascular_system_phenoty0.76215375
76MP0000015_abnormal_ear_pigmentation0.75500006
77MP0010386_abnormal_urinary_bladder0.74109934
78MP0005646_abnormal_pituitary_gland0.70726381
79MP0006072_abnormal_retinal_apoptosis0.67096096
80MP0008469_abnormal_protein_level0.64814782
81MP0005389_reproductive_system_phenotype0.62182908
82MP0001243_abnormal_dermal_layer0.58893441
83MP0002877_abnormal_melanocyte_morpholog0.55690570
84MP0000747_muscle_weakness0.54681077
85MP0008872_abnormal_physiological_respon0.54464481
86MP0000490_abnormal_crypts_of0.54257552
87MP0002249_abnormal_larynx_morphology0.53636621
88MP0005310_abnormal_salivary_gland0.52807404
89MP0002163_abnormal_gland_morphology0.51726285
90MP0000477_abnormal_intestine_morphology0.51700842
91MP0000569_abnormal_digit_pigmentation0.51103785
92MP0004130_abnormal_muscle_cell0.49854075
93MP0005410_abnormal_fertilization0.49609928
94MP0003868_abnormal_feces_composition0.49309494
95MP0001944_abnormal_pancreas_morphology0.47884056
96MP0005409_darkened_coat_color0.47518270
97MP0003045_fibrosis0.47392435
98MP0002136_abnormal_kidney_physiology0.47059678
99MP0002127_abnormal_cardiovascular_syste0.46862136
100MP0003795_abnormal_bone_structure0.46444538

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)6.74243800
2Abnormality of T cell number (HP:0011839)6.38847848
3T lymphocytopenia (HP:0005403)6.12752382
4Abnormality of the columella (HP:0009929)6.07884202
5Eosinophilia (HP:0001880)6.01641278
6Thyroiditis (HP:0100646)5.80241413
7Severe combined immunodeficiency (HP:0004430)5.76441897
8B lymphocytopenia (HP:0010976)5.32933711
9Panhypogammaglobulinemia (HP:0003139)5.29154388
10Abnormality of eosinophils (HP:0001879)5.17722892
11Granulocytopenia (HP:0001913)5.10848360
12Autoimmune hemolytic anemia (HP:0001890)4.93944783
13Hypoplasia of the thymus (HP:0000778)4.86643218
14IgG deficiency (HP:0004315)4.83638758
15Combined immunodeficiency (HP:0005387)4.71309315
16Reduced antithrombin III activity (HP:0001976)4.69077746
17Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.37978130
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.22378160
19Abnormality of T cells (HP:0002843)4.17314306
20Autoimmune thrombocytopenia (HP:0001973)4.14235928
21Recurrent fungal infections (HP:0002841)3.89818741
22Stomach cancer (HP:0012126)3.82234183
23Leukocytosis (HP:0001974)3.68971185
24Abnormality of the frontal sinuses (HP:0002687)3.66614738
25Recurrent viral infections (HP:0004429)3.62055238
26Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.55129777
27IgM deficiency (HP:0002850)3.40099089
28Hypoproteinemia (HP:0003075)3.38276602
29Thoracic kyphosis (HP:0002942)3.35053238
30Increased IgM level (HP:0003496)3.29277811
31Colitis (HP:0002583)3.25904190
32Chronic diarrhea (HP:0002028)3.24111506
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07093231
34Unsteady gait (HP:0002317)2.91566611
35Hematochezia (HP:0002573)2.89471563
36Inflammation of the large intestine (HP:0002037)2.84351194
37Meningitis (HP:0001287)2.78414976
38Vasculitis (HP:0002633)2.71969392
39High anterior hairline (HP:0009890)2.70586976
40Abnormality of cells of the lymphoid lineage (HP:0012140)2.69383166
41Gastrointestinal inflammation (HP:0004386)2.63011624
42Chronic mucocutaneous candidiasis (HP:0002728)2.62171840
43Recurrent cutaneous fungal infections (HP:0011370)2.62171840
44IgA deficiency (HP:0002720)2.58617022
45Recurrent sinusitis (HP:0011108)2.56316149
46Abnormality of T cell physiology (HP:0011840)2.52346733
47Lymphopenia (HP:0001888)2.46546998
48Eczematoid dermatitis (HP:0000976)2.45315330
49Basal ganglia calcification (HP:0002135)2.43771223
50Recurrent bronchitis (HP:0002837)2.39532661
51Thoracolumbar scoliosis (HP:0002944)2.35467401
52Aplastic anemia (HP:0001915)2.33993407
53Papilloma (HP:0012740)2.24537682
54Verrucae (HP:0200043)2.24537682
55Lymphoma (HP:0002665)2.24474316
56Stomatitis (HP:0010280)2.23282455
57Pustule (HP:0200039)2.17480102
58Gastrointestinal infarctions (HP:0005244)2.15241609
59Lower limb hyperreflexia (HP:0002395)2.13046707
60Elevated erythrocyte sedimentation rate (HP:0003565)2.12060843
61Facial hemangioma (HP:0000329)2.11126493
62Abnormality of the intrinsic pathway (HP:0010989)2.07650365
63Abnormality of the thoracic spine (HP:0100711)2.07331095
64Papilledema (HP:0001085)2.06009046
65Encephalitis (HP:0002383)2.05930907
66Hypothermia (HP:0002045)2.04776763
67Self-mutilation (HP:0000742)2.01717246
68Optic neuritis (HP:0100653)1.96700697
69Retrobulbar optic neuritis (HP:0100654)1.96700697
70Aplasia cutis congenita (HP:0001057)1.96636123
71Agammaglobulinemia (HP:0004432)1.96358302
72Acute lymphatic leukemia (HP:0006721)1.94482736
73Mediastinal lymphadenopathy (HP:0100721)1.93701918
74Absent thumb (HP:0009777)1.88195177
75Capillary hemangiomas (HP:0005306)1.87869471
76Joint swelling (HP:0001386)1.82822291
77Erythroderma (HP:0001019)1.79850901
78Spontaneous hematomas (HP:0007420)1.78041661
79Increased IgE level (HP:0003212)1.75372392
80Myositis (HP:0100614)1.75283185
81Pulmonary infiltrates (HP:0002113)1.72946481
82Centrally nucleated skeletal muscle fibers (HP:0003687)1.72518439
83Renal cortical cysts (HP:0000803)1.72458803
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.72235038
85Congenital stationary night blindness (HP:0007642)1.70980880
86Hemoptysis (HP:0002105)1.70398296
87Sensory axonal neuropathy (HP:0003390)1.69499038
88Hypochromic anemia (HP:0001931)1.67502570
89Carpal bone hypoplasia (HP:0001498)1.67435863
90Abnormality of the prostate (HP:0008775)1.67229477
91Pulmonary embolism (HP:0002204)1.67095292
92Abnormality of the lumbar spine (HP:0100712)1.65539462
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64079711
94Prominent nose (HP:0000448)1.62876083
95Atonic seizures (HP:0010819)1.61351604
96Recurrent bacterial skin infections (HP:0005406)1.61074254
97Hypergammaglobulinemia (HP:0010702)1.59935741
98Abnormality of macrophages (HP:0004311)1.57259147
99Basal cell carcinoma (HP:0002671)1.56561282
100Abnormal glycosylation (HP:0012345)1.56421614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NLK4.70573993
2PINK14.38046677
3MARK34.03125967
4ZAP703.45537713
5CSNK1A1L2.98935926
6MAP3K102.94754535
7MAP4K12.85499777
8CSNK1G32.80286523
9GRK62.45508091
10TLK12.41894860
11MAP2K72.41878153
12NEK22.19311342
13CSNK1G12.15849868
14CSNK1G22.09282056
15TXK1.95694657
16BTK1.94408479
17FES1.90443800
18CAMKK21.86514606
19ZAK1.84121089
20TAOK31.75125716
21CAMKK11.73863608
22SYK1.71132624
23RPS6KA41.64214107
24PASK1.59859592
25FRK1.58496389
26PRKCQ1.53965761
27CDK31.49593380
28JAK11.33673277
29BLK1.31424125
30ITK1.28552138
31PDGFRB1.27097274
32SGK4941.25454087
33SGK2231.25454087
34MELK1.18918345
35RPS6KA51.15520804
36BMPR1B1.13480108
37MAP3K11.08390393
38KDR1.04660007
39HCK1.02460640
40STK40.97000999
41FGFR20.94826146
42MAP3K50.90233779
43MAP3K130.88754568
44DYRK30.83383229
45CDK120.81122054
46SGK20.79925121
47IKBKE0.79750578
48LCK0.79648126
49MYLK0.76914694
50CSK0.76701044
51MAP3K30.73622917
52TYK20.67911281
53CAMK40.67344470
54JAK30.67265656
55FGFR30.66862492
56OBSCN0.66062396
57MAPK120.64230836
58VRK10.63182356
59RPS6KB10.61616414
60TRPM70.61309491
61IRAK40.60754661
62PIM10.57783794
63TNK20.57298666
64EIF2AK30.56231997
65LYN0.55157197
66TGFBR10.52739325
67MAPK110.52511507
68SGK30.52354481
69RET0.50040909
70TEC0.49173838
71NME20.49051909
72CLK10.49008107
73TAOK10.48872004
74HIPK20.47454093
75PDK10.45123086
76PIK3CG0.43635504
77ICK0.43268345
78RIPK40.42925309
79CDK80.39711737
80CSNK1A10.39608739
81CDK40.39455490
82CSNK1D0.39197014
83PTK2B0.38257920
84NEK60.37808351
85EGFR0.37616510
86FGR0.36826055
87ADRBK20.35576367
88JAK20.35219249
89MAP3K120.34996027
90PDPK10.31657154
91MAPK150.29819454
92LATS10.29545166
93PKN20.29451792
94FGFR40.25580456
95WEE10.23669512
96MAP3K110.23431113
97GRK10.23130153
98TAOK20.21937585
99CAMK10.21922630
100ATM0.21284997

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.90967311
2T cell receptor signaling pathway_Homo sapiens_hsa046603.47093064
3Olfactory transduction_Homo sapiens_hsa047403.29247396
4Systemic lupus erythematosus_Homo sapiens_hsa053222.89820058
5Phototransduction_Homo sapiens_hsa047442.62931132
6Alcoholism_Homo sapiens_hsa050342.43350569
7B cell receptor signaling pathway_Homo sapiens_hsa046622.25242241
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.25079832
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.22482448
10Hematopoietic cell lineage_Homo sapiens_hsa046402.14724361
11Autoimmune thyroid disease_Homo sapiens_hsa053201.86502663
12Renin secretion_Homo sapiens_hsa049241.85562617
13Graft-versus-host disease_Homo sapiens_hsa053321.82473776
14Allograft rejection_Homo sapiens_hsa053301.76144194
15Salivary secretion_Homo sapiens_hsa049701.57607915
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54863883
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51222730
18Oxytocin signaling pathway_Homo sapiens_hsa049211.50789855
19Antigen processing and presentation_Homo sapiens_hsa046121.50006150
20Measles_Homo sapiens_hsa051621.49227206
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.45260048
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44472406
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38878534
24Amphetamine addiction_Homo sapiens_hsa050311.36279217
25Hepatitis B_Homo sapiens_hsa051611.36009236
26Long-term potentiation_Homo sapiens_hsa047201.35472781
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30371510
28Apoptosis_Homo sapiens_hsa042101.28988300
29Glioma_Homo sapiens_hsa052141.24334715
30Viral carcinogenesis_Homo sapiens_hsa052031.21170950
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19458458
32Type I diabetes mellitus_Homo sapiens_hsa049401.18646288
33Thyroid cancer_Homo sapiens_hsa052161.18404618
34Endometrial cancer_Homo sapiens_hsa052131.15004135
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.14434338
36Acute myeloid leukemia_Homo sapiens_hsa052211.14168354
37Gastric acid secretion_Homo sapiens_hsa049711.12811499
38Pertussis_Homo sapiens_hsa051331.09639161
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08699937
40Osteoclast differentiation_Homo sapiens_hsa043801.05817062
41Tuberculosis_Homo sapiens_hsa051521.04469380
42Herpes simplex infection_Homo sapiens_hsa051681.00369867
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98986284
44Melanogenesis_Homo sapiens_hsa049160.97413994
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96814747
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.95838754
47TNF signaling pathway_Homo sapiens_hsa046680.90932432
48Viral myocarditis_Homo sapiens_hsa054160.90849294
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90791009
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88607610
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88131786
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.88034430
53Non-small cell lung cancer_Homo sapiens_hsa052230.85159810
54Circadian entrainment_Homo sapiens_hsa047130.78845627
55Prostate cancer_Homo sapiens_hsa052150.78660659
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78327983
57Chemical carcinogenesis_Homo sapiens_hsa052040.77508058
58Estrogen signaling pathway_Homo sapiens_hsa049150.76550156
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76453729
60Calcium signaling pathway_Homo sapiens_hsa040200.75874082
61Malaria_Homo sapiens_hsa051440.74581292
62Glucagon signaling pathway_Homo sapiens_hsa049220.72039176
63HTLV-I infection_Homo sapiens_hsa051660.71862155
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70592214
65Staphylococcus aureus infection_Homo sapiens_hsa051500.69876774
66FoxO signaling pathway_Homo sapiens_hsa040680.69869070
67GnRH signaling pathway_Homo sapiens_hsa049120.69688509
68Asthma_Homo sapiens_hsa053100.69087375
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.65270204
70DNA replication_Homo sapiens_hsa030300.65162506
71Platelet activation_Homo sapiens_hsa046110.61124198
72Ras signaling pathway_Homo sapiens_hsa040140.59183997
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.58680321
74Chemokine signaling pathway_Homo sapiens_hsa040620.55053648
75Leishmaniasis_Homo sapiens_hsa051400.55044370
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54964935
77Oocyte meiosis_Homo sapiens_hsa041140.53924095
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53311600
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51852880
80MAPK signaling pathway_Homo sapiens_hsa040100.48452861
81Taste transduction_Homo sapiens_hsa047420.46839743
82Influenza A_Homo sapiens_hsa051640.43945672
83Rap1 signaling pathway_Homo sapiens_hsa040150.42981778
84cAMP signaling pathway_Homo sapiens_hsa040240.42528338
85Epstein-Barr virus infection_Homo sapiens_hsa051690.41239997
86RNA degradation_Homo sapiens_hsa030180.40084016
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38049670
88Insulin signaling pathway_Homo sapiens_hsa049100.37507886
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37237520
90Colorectal cancer_Homo sapiens_hsa052100.36728267
91Hepatitis C_Homo sapiens_hsa051600.36082782
92Wnt signaling pathway_Homo sapiens_hsa043100.34274504
93Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33272969
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32573499
95Hedgehog signaling pathway_Homo sapiens_hsa043400.32491683
96Nitrogen metabolism_Homo sapiens_hsa009100.32268607
97Fanconi anemia pathway_Homo sapiens_hsa034600.31654547
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31388273
99mTOR signaling pathway_Homo sapiens_hsa041500.30570776
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30387683

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