ANXA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.84684614
2intestinal cholesterol absorption (GO:0030299)9.59272054
3angiotensin maturation (GO:0002003)9.22788292
4regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.01604114
5vitamin A metabolic process (GO:0006776)5.97928144
6hormone catabolic process (GO:0042447)5.51184169
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.32229993
8indolalkylamine metabolic process (GO:0006586)5.14321490
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.07925621
10UDP-N-acetylglucosamine metabolic process (GO:0006047)5.07327602
11actin filament depolymerization (GO:0030042)5.03291903
12phospholipid efflux (GO:0033700)4.94264337
13serotonin metabolic process (GO:0042428)4.85575551
14regulation of cholesterol esterification (GO:0010872)4.85548801
15regulation of triglyceride catabolic process (GO:0010896)4.82155014
16virion attachment to host cell (GO:0019062)4.81683964
17adhesion of symbiont to host cell (GO:0044650)4.81683964
18peptide catabolic process (GO:0043171)4.73062957
19plasma lipoprotein particle assembly (GO:0034377)4.65569387
20tryptophan catabolic process (GO:0006569)4.65366070
21indole-containing compound catabolic process (GO:0042436)4.65366070
22indolalkylamine catabolic process (GO:0046218)4.65366070
23primary amino compound metabolic process (GO:1901160)4.59391570
24positive regulation of triglyceride lipase activity (GO:0061365)4.57478719
25positive regulation of lipoprotein lipase activity (GO:0051006)4.57478719
26protein-lipid complex assembly (GO:0065005)4.52485780
27lipoprotein metabolic process (GO:0042157)4.49417411
28reverse cholesterol transport (GO:0043691)4.36059480
29lactate metabolic process (GO:0006089)4.34928760
30digestive system process (GO:0022600)4.23908085
31indole-containing compound metabolic process (GO:0042430)4.14893094
32flavonoid metabolic process (GO:0009812)4.14388764
33cholesterol efflux (GO:0033344)4.12258953
34drug catabolic process (GO:0042737)4.11843195
35transcytosis (GO:0045056)4.10728010
36intestinal epithelial cell development (GO:0060576)4.08779577
37positive regulation of fatty acid biosynthetic process (GO:0045723)4.02651943
38transepithelial transport (GO:0070633)4.02346330
39NADH metabolic process (GO:0006734)3.96482115
40digestion (GO:0007586)3.92149999
41adhesion of symbiont to host (GO:0044406)3.90672459
42kynurenine metabolic process (GO:0070189)3.87436391
43glucose 6-phosphate metabolic process (GO:0051156)3.85042873
44cholesterol homeostasis (GO:0042632)3.82325112
45regulation of cholesterol homeostasis (GO:2000188)3.81711691
46purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.80338263
473-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.80338263
48sterol homeostasis (GO:0055092)3.79145184
49hepatocyte apoptotic process (GO:0097284)3.77680197
50tryptophan metabolic process (GO:0006568)3.77269195
51regulation of bile acid biosynthetic process (GO:0070857)3.76994237
52cholesterol transport (GO:0030301)3.75250565
53sterol transport (GO:0015918)3.75250565
54cellular ketone body metabolic process (GO:0046950)3.74545020
55phosphatidylserine acyl-chain remodeling (GO:0036150)3.71681567
56high-density lipoprotein particle remodeling (GO:0034375)3.70811244
57epoxygenase P450 pathway (GO:0019373)3.70261506
58uronic acid metabolic process (GO:0006063)3.70088326
59glucuronate metabolic process (GO:0019585)3.70088326
60very-low-density lipoprotein particle assembly (GO:0034379)3.68390362
61regulation of guanylate cyclase activity (GO:0031282)3.68017389
62negative regulation of sterol transport (GO:0032372)3.67816103
63negative regulation of cholesterol transport (GO:0032375)3.67816103
64cellular glucuronidation (GO:0052695)3.67205300
65drug metabolic process (GO:0017144)3.66716721
66exogenous drug catabolic process (GO:0042738)3.64208331
67sulfation (GO:0051923)3.61901642
68diacylglycerol metabolic process (GO:0046339)3.57552180
69photoreceptor cell maintenance (GO:0045494)3.52116738
70peptide hormone processing (GO:0016486)3.49269887
71aromatic amino acid family catabolic process (GO:0009074)3.49189981
72desmosome organization (GO:0002934)3.47515512
73behavioral response to nicotine (GO:0035095)3.46408098
74protein-lipid complex remodeling (GO:0034368)3.44769832
75macromolecular complex remodeling (GO:0034367)3.44769832
76plasma lipoprotein particle remodeling (GO:0034369)3.44769832
77hemidesmosome assembly (GO:0031581)3.41809534
78calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.41730968
79fucose catabolic process (GO:0019317)3.40818510
80L-fucose metabolic process (GO:0042354)3.40818510
81L-fucose catabolic process (GO:0042355)3.40818510
82lipoprotein transport (GO:0042953)3.37831875
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.36824149
84amine catabolic process (GO:0009310)3.36734965
85cellular biogenic amine catabolic process (GO:0042402)3.36734965
86water-soluble vitamin biosynthetic process (GO:0042364)3.34876591
87oxidative demethylation (GO:0070989)3.34861493
88ketone body metabolic process (GO:1902224)3.34766035
89aromatic amino acid family metabolic process (GO:0009072)3.33836159
90sulfate transmembrane transport (GO:1902358)3.33513851
91detection of light stimulus involved in visual perception (GO:0050908)3.32389353
92detection of light stimulus involved in sensory perception (GO:0050962)3.32389353
93modified amino acid transport (GO:0072337)3.31405749
94arginine metabolic process (GO:0006525)3.28808911
95antibacterial humoral response (GO:0019731)3.25976297
96alkaloid metabolic process (GO:0009820)3.25889637
97positive regulation of guanylate cyclase activity (GO:0031284)3.24640961
98protein-lipid complex subunit organization (GO:0071825)3.22661221
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22602760
100response to hydroperoxide (GO:0033194)3.21027128
101plasma lipoprotein particle organization (GO:0071827)3.20926345
102antimicrobial humoral response (GO:0019730)3.20399873
103bile acid and bile salt transport (GO:0015721)3.19875235
104positive regulation of triglyceride metabolic process (GO:0090208)3.17638954
105innate immune response in mucosa (GO:0002227)3.12918423
106hypotonic response (GO:0006971)3.12380970
107regulation of lipoprotein metabolic process (GO:0050746)3.11396855
108cellular response to hepatocyte growth factor stimulus (GO:0035729)3.11239261
109response to hepatocyte growth factor (GO:0035728)3.11239261
110defense response to fungus (GO:0050832)3.10216343
111cytoskeletal anchoring at plasma membrane (GO:0007016)3.09788154
112auditory receptor cell differentiation (GO:0042491)3.04478991
113oligosaccharide catabolic process (GO:0009313)3.02910616
114thrombin receptor signaling pathway (GO:0070493)2.99686889
115regulation of digestive system process (GO:0044058)2.99308152
116galactose catabolic process (GO:0019388)2.98050145
117drug transmembrane transport (GO:0006855)2.95833829
118positive regulation of lipid catabolic process (GO:0050996)2.94456416
119response to phenylpropanoid (GO:0080184)2.94329707
120arginine catabolic process (GO:0006527)2.94141006
121urea metabolic process (GO:0019627)2.93961130
122urea cycle (GO:0000050)2.93961130
123tight junction assembly (GO:0070830)2.92787990
124phospholipid homeostasis (GO:0055091)2.91041437
125disruption of cells of other organism (GO:0044364)2.89918461
126killing of cells of other organism (GO:0031640)2.89918461
127phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.89814137
128COPII vesicle coating (GO:0048208)2.86444050
129sulfate transport (GO:0008272)2.84675318
130proline transport (GO:0015824)2.83364422
131negative regulation of digestive system process (GO:0060457)2.83073066
132cilium or flagellum-dependent cell motility (GO:0001539)2.82818956
133beta-amyloid metabolic process (GO:0050435)2.81198766
134S-adenosylmethionine metabolic process (GO:0046500)2.80619517
135vitamin biosynthetic process (GO:0009110)2.79740222
136lipid homeostasis (GO:0055088)2.79067278
137cysteine metabolic process (GO:0006534)2.78856909
138negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.77386896
139epithelial cell-cell adhesion (GO:0090136)2.76827879
140C4-dicarboxylate transport (GO:0015740)2.76218592
141regulation of transforming growth factor beta1 production (GO:0032908)2.75501275
142drug transport (GO:0015893)2.74768547
143bile acid metabolic process (GO:0008206)2.73603831
144O-glycan processing (GO:0016266)2.73540210
145glial cell proliferation (GO:0014009)2.73394558
146auditory receptor cell stereocilium organization (GO:0060088)2.73031018
147phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72734206
148benzene-containing compound metabolic process (GO:0042537)2.72715513
149regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.72172711
150polyol transport (GO:0015791)2.71404549
151regulation of cholesterol transport (GO:0032374)2.69781320
152regulation of sterol transport (GO:0032371)2.69781320
153homocysteine metabolic process (GO:0050667)2.69493213
154membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.69337293
155phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63700509
156sperm motility (GO:0030317)2.63383253
157epithelial cilium movement (GO:0003351)2.62375999
158response to pheromone (GO:0019236)2.61790300
159glyoxylate metabolic process (GO:0046487)2.61556611
160signal peptide processing (GO:0006465)2.61211393
161establishment of protein localization to Golgi (GO:0072600)2.58825950
162behavioral response to ethanol (GO:0048149)2.56086743
163NAD biosynthetic process (GO:0009435)2.52385961
164positive regulation of fatty acid transport (GO:2000193)2.50706891
165L-ascorbic acid metabolic process (GO:0019852)2.50637992
166axoneme assembly (GO:0035082)2.47623882
167regulation of acrosome reaction (GO:0060046)2.46411898
168amine metabolic process (GO:0009308)2.44333086
169phosphatidylethanolamine biosynthetic process (GO:0006646)2.44016167
170platelet dense granule organization (GO:0060155)2.43826428
171neurotransmitter metabolic process (GO:0042133)2.42752919
172phosphatidylethanolamine metabolic process (GO:0046337)2.40251761
173nucleobase catabolic process (GO:0046113)2.37584221
174cellular biogenic amine metabolic process (GO:0006576)2.37265696
175cellular amine metabolic process (GO:0044106)2.37265696
176glycine transport (GO:0015816)2.36050768
177inner ear receptor stereocilium organization (GO:0060122)2.35265485
178peristalsis (GO:0030432)2.35023861
179phosphatidylserine metabolic process (GO:0006658)2.33264100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.20910996
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.38416342
3* SOX2_27498859_Chip-Seq_STOMACH_Mouse3.81305478
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65542017
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49560416
6VDR_22108803_ChIP-Seq_LS180_Human3.27415649
7ZNF274_21170338_ChIP-Seq_K562_Hela3.19258474
8* GATA4_25053715_ChIP-Seq_YYC3_Human3.06170013
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.01964036
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.89397450
11GBX2_23144817_ChIP-Seq_PC3_Human2.85249658
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.83228304
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.82199760
14GATA6_25053715_ChIP-Seq_YYC3_Human2.77873273
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.77199669
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.75591719
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.71839802
18GATA1_22025678_ChIP-Seq_K562_Human2.64687655
19* SOX2_20726797_ChIP-Seq_SW620_Human2.63034376
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.60865151
21PPAR_26484153_Chip-Seq_NCI-H1993_Human2.52831403
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.42610376
23CLOCK_20551151_ChIP-Seq_293T_Human2.39965079
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.32789731
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30543316
26FOXO3_23340844_ChIP-Seq_DLD1_Human2.28881595
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25757262
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22421496
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22235699
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.15700790
31IGF1R_20145208_ChIP-Seq_DFB_Human2.15526158
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03562765
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.02208793
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96321166
35ZNF263_19887448_ChIP-Seq_K562_Human1.95601026
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94945934
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94836543
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93536386
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93448124
40ER_23166858_ChIP-Seq_MCF-7_Human1.92663894
41BCAT_22108803_ChIP-Seq_LS180_Human1.90783238
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87149277
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86225005
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85843393
45P300_19829295_ChIP-Seq_ESCs_Human1.84534271
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84187564
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82256075
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.82202904
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81455782
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.80607060
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79643038
52CBP_20019798_ChIP-Seq_JUKART_Human1.79643038
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78626020
54FUS_26573619_Chip-Seq_HEK293_Human1.78307688
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73772568
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73711792
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71717413
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70823979
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68671524
60KLF5_25053715_ChIP-Seq_YYC3_Human1.66001071
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64367576
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.63315108
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62639734
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60460522
65AR_21909140_ChIP-Seq_LNCAP_Human1.59148751
66SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.59008967
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.59008967
68TCF4_22108803_ChIP-Seq_LS180_Human1.58886515
69STAT3_23295773_ChIP-Seq_U87_Human1.58358452
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.56574415
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.55882524
72TAF15_26573619_Chip-Seq_HEK293_Human1.55061379
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53625323
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53262579
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52393183
76EZH2_22144423_ChIP-Seq_EOC_Human1.52315588
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52084936
78* ATF3_27146783_Chip-Seq_COLON_Human1.51858502
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50549078
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.50149205
81RACK7_27058665_Chip-Seq_MCF-7_Human1.47496908
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.46870714
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.46736254
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46440794
85AR_25329375_ChIP-Seq_VCAP_Human1.44888432
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44023764
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.43979515
88TCF4_18268006_ChIP-ChIP_LS174T_Human1.43829757
89* SMAD4_21799915_ChIP-Seq_A2780_Human1.42019707
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41535743
91TCF4_23295773_ChIP-Seq_U87_Human1.41192330
92* HNF4A_19822575_ChIP-Seq_HepG2_Human1.38026165
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37798783
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.37304957
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37304957
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.37166191
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35658691
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32379836
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31041246
100EWS_26573619_Chip-Seq_HEK293_Human1.27940191
101NANOG_19829295_ChIP-Seq_ESCs_Human1.27480812
102SOX2_19829295_ChIP-Seq_ESCs_Human1.27480812
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27010650
104AR_20517297_ChIP-Seq_VCAP_Human1.26957966
105JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26916122
106SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26114578
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.25694284
108* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25662289
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24910966
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.24815925
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24391406
112* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24355772
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23766833
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23766833
115GATA2_19941826_ChIP-Seq_K562_Human1.22912934
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22160323
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22028032
118NCOR_22424771_ChIP-Seq_293T_Human1.21716153
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21218203
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.20302235
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19120094
122RUNX2_22187159_ChIP-Seq_PCA_Human1.18985639
123ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18127616
124TP53_22573176_ChIP-Seq_HFKS_Human1.18121447
125* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16187599
126GATA3_24758297_ChIP-Seq_MCF-7_Human1.15357974
127DROSHA_22980978_ChIP-Seq_HELA_Human1.14174496
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14110817
129* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13857089
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13362517
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13316949
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.13007232
133AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11421546
134SALL1_21062744_ChIP-ChIP_HESCs_Human1.11118613
135STAT3_18555785_Chip-Seq_ESCs_Mouse1.10389856
136NANOG_18555785_Chip-Seq_ESCs_Mouse1.10317251
137P53_22387025_ChIP-Seq_ESCs_Mouse1.09170056
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08803194
139CJUN_26792858_Chip-Seq_BT549_Human1.08597047
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07711182
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.06105224
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05717839
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05564620
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05130669
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05106248
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04678787
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04441748
148CREB1_26743006_Chip-Seq_LNCaP_Human1.04276582
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.04058856
150CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04004110
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03767556
152P300_18555785_Chip-Seq_ESCs_Mouse1.03470811
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03148468
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02854262
155IRF1_19129219_ChIP-ChIP_H3396_Human1.02597604
156NANOG_20526341_ChIP-Seq_ESCs_Human1.01671506
157E2F1_18555785_Chip-Seq_ESCs_Mouse1.01624143
158CBX2_27304074_Chip-Seq_ESCs_Mouse1.01162590
159BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00815511
160MYC_19829295_ChIP-Seq_ESCs_Human1.00113765
161* TP63_23658742_ChIP-Seq_EP156T_Human0.96441148
162TP53_16413492_ChIP-PET_HCT116_Human0.95806653
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.93267358
164POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92722441
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92589976
166P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90689095
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88339518
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87522063
169P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86201036
170SMAD3_21741376_ChIP-Seq_HESCs_Human0.85671023
171FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85277313
172TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85238660
173AHR_22903824_ChIP-Seq_MCF-7_Human0.85187565
174ELF5_23300383_ChIP-Seq_T47D_Human0.84934079
175CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82545865
176TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81128411
177CDX2_22108803_ChIP-Seq_LS180_Human0.79928912
178* EP300_21415370_ChIP-Seq_HL-1_Mouse0.78911858
179IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.78868133
180NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75966559
181CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75591414
182LXR_22292898_ChIP-Seq_THP-1_Human0.75085658
183EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.72767319
184GATA1_19941826_ChIP-Seq_K562_Human0.72129112
185NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71834086
186NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71834086
187MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.69984521
188NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69133313
189TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67217217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.73533306
2MP0010234_abnormal_vibrissa_follicle5.72903921
3MP0001666_abnormal_nutrient_absorption5.50795194
4MP0002139_abnormal_hepatobiliary_system4.19036045
5MP0000537_abnormal_urethra_morphology3.68660105
6MP0004264_abnormal_extraembryonic_tissu3.54257697
7MP0009840_abnormal_foam_cell3.39588633
8MP0005085_abnormal_gallbladder_physiolo3.27020213
9MP0003252_abnormal_bile_duct3.20906926
10MP0000462_abnormal_digestive_system3.17889279
11MP0003195_calcinosis3.15610263
12MP0003300_gastrointestinal_ulcer2.85369216
13MP0003183_abnormal_peptide_metabolism2.65049982
14MP0001501_abnormal_sleep_pattern2.62951893
15MP0008875_abnormal_xenobiotic_pharmacok2.60240955
16MP0010329_abnormal_lipoprotein_level2.56044007
17MP0003787_abnormal_imprinting2.53436708
18MP0005551_abnormal_eye_electrophysiolog2.41110943
19MP0003866_abnormal_defecation2.37687578
20MP0010352_gastrointestinal_tract_polyps2.34276583
21MP0005084_abnormal_gallbladder_morpholo2.16842108
22MP0006276_abnormal_autonomic_nervous2.08179619
23MP0005365_abnormal_bile_salt2.02168856
24MP0006054_spinal_hemorrhage2.01023298
25MP0003705_abnormal_hypodermis_morpholog2.00419077
26MP0004019_abnormal_vitamin_homeostasis1.99962976
27MP0001485_abnormal_pinna_reflex1.96004509
28MP0001664_abnormal_digestion1.90641927
29MP0008877_abnormal_DNA_methylation1.86046085
30MP0000538_abnormal_urinary_bladder1.84102122
31MP0005645_abnormal_hypothalamus_physiol1.82154663
32MP0004147_increased_porphyrin_level1.81471800
33MP0002796_impaired_skin_barrier1.64726847
34MP0001873_stomach_inflammation1.64276472
35MP0010155_abnormal_intestine_physiology1.61427653
36MP0005381_digestive/alimentary_phenotyp1.60897310
37MP0002102_abnormal_ear_morphology1.58088654
38MP0001663_abnormal_digestive_system1.54470307
39MP0003646_muscle_fatigue1.53525473
40MP0010678_abnormal_skin_adnexa1.53125080
41MP0005410_abnormal_fertilization1.52427631
42MP0000477_abnormal_intestine_morphology1.49449829
43MP0005670_abnormal_white_adipose1.45944426
44MP0002736_abnormal_nociception_after1.44234064
45MP0000427_abnormal_hair_cycle1.44197402
46MP0001968_abnormal_touch/_nociception1.37958024
47MP0000569_abnormal_digit_pigmentation1.37013870
48MP0005332_abnormal_amino_acid1.35882754
49MP0005646_abnormal_pituitary_gland1.33032963
50MP0005253_abnormal_eye_physiology1.29214610
51MP0002938_white_spotting1.28462497
52MP0009384_cardiac_valve_regurgitation1.27864282
53MP0009643_abnormal_urine_homeostasis1.25237587
54MP0008004_abnormal_stomach_pH1.24365631
55MP0005174_abnormal_tail_pigmentation1.22297104
56MP0010386_abnormal_urinary_bladder1.21930404
57MP0004043_abnormal_pH_regulation1.21407949
58MP0002822_catalepsy1.19587857
59MP0009780_abnormal_chondrocyte_physiolo1.15597448
60MP0005501_abnormal_skin_physiology1.15190851
61MP0000490_abnormal_crypts_of1.12672376
62MP0002557_abnormal_social/conspecific_i1.10470173
63MP0003191_abnormal_cellular_cholesterol1.10401999
64MP0002118_abnormal_lipid_homeostasis1.10096013
65MP0005448_abnormal_energy_balance1.09710476
66MP0003880_abnormal_central_pattern1.09364685
67MP0005167_abnormal_blood-brain_barrier1.09206170
68MP0000609_abnormal_liver_physiology1.08719704
69MP0009379_abnormal_foot_pigmentation1.08622994
70MP0006292_abnormal_olfactory_placode1.07824130
71MP0001486_abnormal_startle_reflex1.07560562
72MP0002837_dystrophic_cardiac_calcinosis1.05372003
73MP0002254_reproductive_system_inflammat1.04427858
74MP0000372_irregular_coat_pigmentation1.03451219
75MP0001986_abnormal_taste_sensitivity1.02983247
76MP0009745_abnormal_behavioral_response1.02305972
77MP0005389_reproductive_system_phenotype1.01922618
78MP0003453_abnormal_keratinocyte_physiol1.01004650
79MP0002098_abnormal_vibrissa_morphology1.00800042
80MP0006072_abnormal_retinal_apoptosis1.00738315
81MP0001849_ear_inflammation1.00177858
82MP0005166_decreased_susceptibility_to0.99840951
83MP0004947_skin_inflammation0.98124888
84MP0002272_abnormal_nervous_system0.97151729
85MP0001765_abnormal_ion_homeostasis0.97117256
86MP0000383_abnormal_hair_follicle0.96213184
87MP0002160_abnormal_reproductive_system0.96166199
88MP0002138_abnormal_hepatobiliary_system0.92832911
89MP0002089_abnormal_postnatal_growth/wei0.91668978
90MP0003950_abnormal_plasma_membrane0.90833522
91MP0001756_abnormal_urination0.88131335
92MP0001970_abnormal_pain_threshold0.87722401
93MP0003868_abnormal_feces_composition0.87481963
94MP0004142_abnormal_muscle_tone0.87406967
95MP0009053_abnormal_anal_canal0.85357926
96MP0005647_abnormal_sex_gland0.84264924
97MP0003283_abnormal_digestive_organ0.83805819
98MP0001216_abnormal_epidermal_layer0.83784467
99MP0004885_abnormal_endolymph0.83731004
100MP0009046_muscle_twitch0.83174841
101MP0000566_synostosis0.83167469
102MP0002909_abnormal_adrenal_gland0.83150992
103MP0003045_fibrosis0.82794722
104MP0005220_abnormal_exocrine_pancreas0.82616844
105MP0008775_abnormal_heart_ventricle0.82056874
106MP0002693_abnormal_pancreas_physiology0.82024965
107MP0002229_neurodegeneration0.81030061
108MP0002733_abnormal_thermal_nociception0.80677851
109MP0003698_abnormal_male_reproductive0.80546190
110MP0002136_abnormal_kidney_physiology0.80059396
111MP0005319_abnormal_enzyme/_coenzyme0.80000204
112MP0004145_abnormal_muscle_electrophysio0.79988722
113MP0005195_abnormal_posterior_eye0.79562696
114MP0004185_abnormal_adipocyte_glucose0.78466363
115MP0001919_abnormal_reproductive_system0.78317709
116MP0005386_behavior/neurological_phenoty0.77846487
117MP0004924_abnormal_behavior0.77846487
118MP0005310_abnormal_salivary_gland0.76889188
119MP0002572_abnormal_emotion/affect_behav0.75607841
120MP0000631_abnormal_neuroendocrine_gland0.74082337
121MP0003953_abnormal_hormone_level0.73879144
122MP0003011_delayed_dark_adaptation0.73547826
123MP0000467_abnormal_esophagus_morphology0.73141452
124MP0002064_seizures0.72376181
125MP0005367_renal/urinary_system_phenotyp0.71670051
126MP0005395_other_phenotype0.71191334
127MP0002060_abnormal_skin_morphology0.70913029
128MP0009765_abnormal_xenobiotic_induced0.69375512
129MP0005636_abnormal_mineral_homeostasis0.68725754
130MP0001764_abnormal_homeostasis0.68360093
131MP0003806_abnormal_nucleotide_metabolis0.67935069
132MP0005083_abnormal_biliary_tract0.67607681
133MP0003878_abnormal_ear_physiology0.67193796
134MP0005377_hearing/vestibular/ear_phenot0.67193796
135MP0003566_abnormal_cell_adhesion0.65588096
136MP0005666_abnormal_adipose_tissue0.65429122
137MP0000470_abnormal_stomach_morphology0.64912939
138MP0002876_abnormal_thyroid_physiology0.64772122
139MP0005023_abnormal_wound_healing0.64627113
140MP0001191_abnormal_skin_condition0.58661355
141MP0003638_abnormal_response/metabolism_0.58000986
142MP0001881_abnormal_mammary_gland0.57784876
143MP0003315_abnormal_perineum_morphology0.57510676
144MP0000613_abnormal_salivary_gland0.57378973
145MP0003119_abnormal_digestive_system0.56591488
146MP0000604_amyloidosis0.55851212
147MP0010771_integument_phenotype0.55601879
148MP0000230_abnormal_systemic_arterial0.55420119
149MP0008872_abnormal_physiological_respon0.53189111
150MP0005187_abnormal_penis_morphology0.52998904
151MP0002166_altered_tumor_susceptibility0.52581195
152MP0003718_maternal_effect0.52566014
153MP0009764_decreased_sensitivity_to0.51080269
154MP0000377_abnormal_hair_follicle0.50540197
155MP0002928_abnormal_bile_duct0.47427855
156MP0003115_abnormal_respiratory_system0.47418418
157MP0009642_abnormal_blood_homeostasis0.46605886
158MP0000516_abnormal_urinary_system0.46457992

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.31641635
2Right ventricular cardiomyopathy (HP:0011663)5.93343844
3Acanthocytosis (HP:0001927)5.77547652
4Hypobetalipoproteinemia (HP:0003563)5.73157228
5Malnutrition (HP:0004395)5.54335787
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.33636667
7Potter facies (HP:0002009)4.72950230
8Facial shape deformation (HP:0011334)4.72950230
9Hydroxyprolinuria (HP:0003080)4.26913305
10Abnormality of proline metabolism (HP:0010907)4.26913305
11Conjugated hyperbilirubinemia (HP:0002908)4.04188228
12Pigmentary retinal degeneration (HP:0001146)3.97922506
13Widely patent fontanelles and sutures (HP:0004492)3.97533608
14Fat malabsorption (HP:0002630)3.85368314
15Pancreatic cysts (HP:0001737)3.73654928
16Abdominal distention (HP:0003270)3.59986759
17Micronodular cirrhosis (HP:0001413)3.54076613
18Hypolipoproteinemia (HP:0010981)3.53959521
19Molar tooth sign on MRI (HP:0002419)3.39454402
20Abnormality of midbrain morphology (HP:0002418)3.39454402
21Pancreatic fibrosis (HP:0100732)3.30813881
22Focal segmental glomerulosclerosis (HP:0000097)3.25018350
23Gastrointestinal dysmotility (HP:0002579)3.16299759
24Aortic aneurysm (HP:0004942)3.08012590
25Intrahepatic cholestasis (HP:0001406)3.06980169
26Abnormality of the gastric mucosa (HP:0004295)3.06787918
27Congenital stationary night blindness (HP:0007642)3.05493961
28Abnormality of the renal cortex (HP:0011035)3.05324486
29True hermaphroditism (HP:0010459)3.04866914
30Poikilocytosis (HP:0004447)3.04801864
31Rectal prolapse (HP:0002035)3.03953160
32Hyperventilation (HP:0002883)3.01598578
33Papilledema (HP:0001085)2.98210508
34Autoimmune thrombocytopenia (HP:0001973)2.98115310
35Attenuation of retinal blood vessels (HP:0007843)2.95986571
36Chronic hepatic failure (HP:0100626)2.94848515
37Decreased circulating renin level (HP:0003351)2.93867461
38Cystic liver disease (HP:0006706)2.92975466
39Increased mean platelet volume (HP:0011877)2.87367003
40Xanthomatosis (HP:0000991)2.84325803
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.76732857
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.73818762
43Autoimmune hemolytic anemia (HP:0001890)2.73577231
44Hypercholesterolemia (HP:0003124)2.72913213
45Abolished electroretinogram (ERG) (HP:0000550)2.71113309
46Tetany (HP:0001281)2.70587397
47Nephronophthisis (HP:0000090)2.70250713
48Progressive cerebellar ataxia (HP:0002073)2.69911603
49Hyperglycinuria (HP:0003108)2.69509706
50Abnormality of purine metabolism (HP:0004352)2.69327263
51Cupped ribs (HP:0000887)2.66877726
52Glomerulosclerosis (HP:0000096)2.64727559
53Wide cranial sutures (HP:0010537)2.64396442
54Abnormal biliary tract morphology (HP:0012440)2.64157722
55Facial diplegia (HP:0001349)2.59334652
56Pendular nystagmus (HP:0012043)2.57802601
57Chorioretinal atrophy (HP:0000533)2.54447146
58Dehydration (HP:0001944)2.54264427
59Abnormality of the renal medulla (HP:0100957)2.53846484
60Esophageal varix (HP:0002040)2.53014080
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.50958536
62Absent/shortened dynein arms (HP:0200106)2.50958536
63Medial flaring of the eyebrow (HP:0010747)2.47859725
64Abnormality of urine glucose concentration (HP:0011016)2.47842141
65Glycosuria (HP:0003076)2.47842141
66Milia (HP:0001056)2.46704545
67Ketosis (HP:0001946)2.45161831
68Chronic diarrhea (HP:0002028)2.45035280
69Hypomagnesemia (HP:0002917)2.44369107
70Subacute progressive viral hepatitis (HP:0006572)2.42164713
71Renal cortical cysts (HP:0000803)2.40668716
72Enlarged kidneys (HP:0000105)2.40158826
73Abnormal platelet volume (HP:0011876)2.40050376
74Severe muscular hypotonia (HP:0006829)2.34813984
75Villous atrophy (HP:0011473)2.33425002
76Abnormality of small intestinal villus morphology (HP:0011472)2.33425002
77Mildly elevated creatine phosphokinase (HP:0008180)2.32217087
78Methylmalonic aciduria (HP:0012120)2.29780052
79Thin bony cortex (HP:0002753)2.29609334
80Gaze-evoked nystagmus (HP:0000640)2.29528466
81Hyperglycinemia (HP:0002154)2.29157125
82Abnormality of the labia minora (HP:0012880)2.25171954
83Metabolic acidosis (HP:0001942)2.25116461
84Hypothermia (HP:0002045)2.22933053
85Biliary tract neoplasm (HP:0100574)2.21466494
86Tubular atrophy (HP:0000092)2.21180548
87Woolly hair (HP:0002224)2.20748725
88Fragile skin (HP:0001030)2.20469591
89Abnormal drinking behavior (HP:0030082)2.20191651
90Polydipsia (HP:0001959)2.20191651
91Pili torti (HP:0003777)2.19415391
92Intestinal atresia (HP:0011100)2.19357091
93Febrile seizures (HP:0002373)2.19118167
94Bony spicule pigmentary retinopathy (HP:0007737)2.18499747
95Progressive sensorineural hearing impairment (HP:0000408)2.17895597
96Flat acetabular roof (HP:0003180)2.16367908
97Exocrine pancreatic insufficiency (HP:0001738)2.14220477
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13309141
99Increased density of long bones (HP:0006392)2.13214978
100Mesangial abnormality (HP:0001966)2.12300857
101Epidermoid cyst (HP:0200040)2.10139370
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10082044
103Abnormal rod and cone electroretinograms (HP:0008323)2.09025967
104Palpitations (HP:0001962)2.08536513
105Congenital sensorineural hearing impairment (HP:0008527)2.07614745
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.06840989
107Abnormal glucose tolerance (HP:0001952)2.06268025
108Abnormality of magnesium homeostasis (HP:0004921)2.05612894
109Abnormality of renin-angiotensin system (HP:0000847)2.04728654
110Proximal tubulopathy (HP:0000114)2.04079413
111Nephrolithiasis (HP:0000787)2.03866824
112Curly hair (HP:0002212)2.02906128
113Abnormal foot bone ossification (HP:0010675)2.01284062
114Volvulus (HP:0002580)2.00124052
115Plantar hyperkeratosis (HP:0007556)1.99757449
116Abnormality of sulfur amino acid metabolism (HP:0004339)1.98709004
117Congenital primary aphakia (HP:0007707)1.98379046
118Abnormality of vitamin metabolism (HP:0100508)1.96878234
119Abnormality of nucleobase metabolism (HP:0010932)1.96681523
120Focal seizures (HP:0007359)1.96493453
121Gait imbalance (HP:0002141)1.96130348
122Spastic diplegia (HP:0001264)1.94981720
123Late onset (HP:0003584)1.94695252
124Pustule (HP:0200039)1.94513010
125Abnormality of serine family amino acid metabolism (HP:0010894)1.94282629
126Abnormality of glycine metabolism (HP:0010895)1.94282629
127Aortic dissection (HP:0002647)1.94104551
128Alkalosis (HP:0001948)1.92862457
129Hyperparathyroidism (HP:0000843)1.91716279
130Ventricular fibrillation (HP:0001663)1.91412972
131Confusion (HP:0001289)1.91353339
132Abnormality of vitamin B metabolism (HP:0004340)1.91248906
133Decreased central vision (HP:0007663)1.91119838
134Hyperammonemia (HP:0001987)1.89405891
135Reticulocytosis (HP:0001923)1.88580473
136Increased purine levels (HP:0004368)1.87964585
137Hyperuricemia (HP:0002149)1.87964585
138Congenital hepatic fibrosis (HP:0002612)1.87903425
139Stomach cancer (HP:0012126)1.87875640
140Lethargy (HP:0001254)1.87447293
141Aplasia/Hypoplasia of the tibia (HP:0005772)1.87444805
142Genetic anticipation (HP:0003743)1.87393328
143Methylmalonic acidemia (HP:0002912)1.86583169
144Hyperlipoproteinemia (HP:0010980)1.86221354
145Abnormality of macular pigmentation (HP:0008002)1.85762127
146Ureteral stenosis (HP:0000071)1.85531395
147Clumsiness (HP:0002312)1.85217048
148Genital tract atresia (HP:0001827)1.83685479
149Cone-rod dystrophy (HP:0000548)1.83558882
150Abnormal respiratory motile cilium morphology (HP:0005938)1.83283441
151Abnormal respiratory epithelium morphology (HP:0012253)1.83283441
152Uterine neoplasm (HP:0010784)1.82986919
153Ketoacidosis (HP:0001993)1.82704294
154Abnormal urine output (HP:0012590)1.82386054
155Pancreatitis (HP:0001733)1.81910596
156Alopecia of scalp (HP:0002293)1.81238491
157Syncope (HP:0001279)1.80912106
158Tubulointerstitial nephritis (HP:0001970)1.80834951
159Keratoconus (HP:0000563)1.80511075
160Increased corneal curvature (HP:0100692)1.80511075
161Progressive hearing impairment (HP:0001730)1.80343393
162Hyperphosphaturia (HP:0003109)1.80282848
163Abnormal urine phosphate concentration (HP:0012599)1.79238669
164Nephrogenic diabetes insipidus (HP:0009806)1.78166173
165Acute encephalopathy (HP:0006846)1.77187538
166Dialeptic seizures (HP:0011146)1.76967697
167Ureteral obstruction (HP:0006000)1.76530227
168Hypoglycemic coma (HP:0001325)1.76440617
169Type II lissencephaly (HP:0007260)1.76083393
170Hepatoblastoma (HP:0002884)1.75740692
171Abnormal ciliary motility (HP:0012262)1.75157162
172Constricted visual fields (HP:0001133)1.74944903
173Fair hair (HP:0002286)1.74357455
174Abnormal tarsal ossification (HP:0008369)1.74178755
175Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74028771
176Abnormality of the nasal septum (HP:0000419)1.71244201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.56760002
2FRK6.15325061
3MST45.92706067
4LMTK25.04802327
5EPHA24.13452451
6MAP4K23.75310551
7MST1R3.36349795
8STK392.93224370
9PRKG22.70680217
10MYLK2.63009158
11BMPR1B2.50630028
12ADRBK22.32637608
13PTK62.29324377
14RIPK12.20105511
15MAP3K22.17487015
16INSRR2.13030031
17WNK32.12558782
18MAP2K22.07747856
19NUAK12.01337399
20TXK1.96704848
21OXSR11.95059281
22MUSK1.94101817
23GRK61.91041168
24ERN11.76700416
25LATS11.73959148
26STK101.69949965
27TNIK1.69646876
28CASK1.65409176
29FER1.64503844
30MET1.58528877
31TTN1.52349131
32TESK11.51802906
33NME11.50047445
34AKT31.39806473
35MAP3K101.39442026
36PINK11.37395825
37SCYL21.31874805
38MAPK131.30127153
39EPHB21.29805414
40TAOK31.26193602
41MAP3K121.21846854
42ZAK1.18305444
43STK38L1.18193621
44DMPK1.15618477
45PAK41.13275322
46TEC1.10889621
47PTK21.08752298
48TLK11.07971201
49MAP3K41.03661723
50PAK21.00633803
51EEF2K0.99105911
52LRRK20.97124109
53PRKCI0.97100343
54RPS6KB20.96883104
55DDR20.95943689
56DAPK20.95426627
57MAP3K80.93651289
58PRKCE0.93524052
59IRAK10.90773543
60ERBB20.84881933
61PKN20.84646578
62TRIB30.81453155
63FGFR20.80410616
64MAP2K10.79475425
65EPHB10.79023090
66EPHA40.77166476
67TRIM280.76296569
68MAP3K30.75662908
69TIE10.71556233
70ADRBK10.71368650
71MKNK20.69618155
72PIK3CG0.69216061
73NTRK30.68680786
74ERBB30.67012526
75MARK30.65104472
76BRSK20.64237789
77MATK0.63958187
78PDGFRA0.63593404
79PTK2B0.60963851
80PRKCG0.60895131
81SIK10.58419774
82MAP2K60.58123423
83NLK0.56340314
84BMX0.56038903
85KSR20.53968631
86PRKAA20.53888536
87CAMK2A0.53315165
88CAMK2G0.52492988
89PIK3CA0.51999239
90EIF2AK30.51803896
91TESK20.49901402
92MAP3K70.49683373
93PAK30.49378839
94GSK3A0.49049169
95CDK190.47969424
96PLK40.47725292
97STK30.47475575
98MAP2K70.47206592
99PHKG20.46724267
100PHKG10.46724267
101BCR0.46254912
102ITK0.46091480
103ROCK10.46050651
104SGK20.46023280
105MARK10.45019195
106EPHA30.44651620
107PRKCZ0.43580523
108TGFBR10.43320654
109PDK20.43108912
110PLK20.42419526
111CAMKK20.41970592
112TNK20.41604629
113PRKCA0.40483270
114DYRK1B0.40341092
115LIMK10.39434564
116PRKACA0.39372479
117GRK50.37794688
118CAMK10.37389788
119AURKB0.37254495
120PAK10.37165280
121CDK60.37134460
122CAMK2B0.36726846
123MAP3K10.36485664
124AKT20.35929130
125IKBKB0.35876286
126CAMK2D0.34828771
127CSNK1A10.34313771
128PBK0.33818649
129PRKACB0.33315239
130MAPK110.33145891
131PDGFRB0.32843815
132DYRK20.32567340
133WNK40.32357635
134ERBB40.30646154
135TBK10.30466932
136CHUK0.30235458
137OBSCN0.29885251
138IGF1R0.29852822
139HIPK20.29827883
140PDPK10.28953519
141BCKDK0.28783661
142MAPKAPK20.28544342
143CSNK1G20.28179551
144SRC0.28083921
145CSNK1G10.27570345
146PRKCQ0.27046072
147PRKAA10.26948558
148PRKACG0.24798901
149CSK0.23840765
150GRK10.23799785
151JAK20.20484182
152ICK0.20349619
153MAP3K110.20228457
154TAOK10.19866636
155MAPK150.19385681
156PDK40.18798310
157PDK30.18798310
158TTK0.18698587
159FGR0.17687718
160PDK10.16979549
161FYN0.16309509
162FLT30.15288555
163CDC42BPA0.15224156
164TRPM70.15206802
165MAPKAPK30.15202357
166EGFR0.15049600

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.59326664
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.36538563
3Renin-angiotensin system_Homo sapiens_hsa046143.88410032
4Vitamin digestion and absorption_Homo sapiens_hsa049773.37202151
5Mineral absorption_Homo sapiens_hsa049783.01640368
6Linoleic acid metabolism_Homo sapiens_hsa005912.72111465
7Sulfur metabolism_Homo sapiens_hsa009202.55350711
8Galactose metabolism_Homo sapiens_hsa000522.36210978
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.31389602
10Starch and sucrose metabolism_Homo sapiens_hsa005002.30727958
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25863152
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.18412782
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18166205
14Caffeine metabolism_Homo sapiens_hsa002322.17698925
15Protein digestion and absorption_Homo sapiens_hsa049742.15982164
16Nitrogen metabolism_Homo sapiens_hsa009102.07483893
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01224504
18Folate biosynthesis_Homo sapiens_hsa007901.89749276
19Fructose and mannose metabolism_Homo sapiens_hsa000511.87464153
20Bile secretion_Homo sapiens_hsa049761.86467301
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84521984
22Ether lipid metabolism_Homo sapiens_hsa005651.62589037
23Phototransduction_Homo sapiens_hsa047441.62415913
24Fatty acid degradation_Homo sapiens_hsa000711.60260371
25Histidine metabolism_Homo sapiens_hsa003401.58819188
26PPAR signaling pathway_Homo sapiens_hsa033201.58626163
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52547118
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.45621679
29Glycerolipid metabolism_Homo sapiens_hsa005611.43828368
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43358717
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39851317
32Arginine biosynthesis_Homo sapiens_hsa002201.39558119
33Homologous recombination_Homo sapiens_hsa034401.38635563
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31463221
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23627733
36Glutathione metabolism_Homo sapiens_hsa004801.22899984
37Tryptophan metabolism_Homo sapiens_hsa003801.22839504
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20185331
39Tight junction_Homo sapiens_hsa045301.18708613
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18254427
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16798016
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13683654
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13225121
44ABC transporters_Homo sapiens_hsa020101.10966788
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09586330
46Pancreatic secretion_Homo sapiens_hsa049720.99357092
47Arginine and proline metabolism_Homo sapiens_hsa003300.97086283
48Pyruvate metabolism_Homo sapiens_hsa006200.94894806
49Sphingolipid metabolism_Homo sapiens_hsa006000.93416816
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93390849
51Carbon metabolism_Homo sapiens_hsa012000.92995197
52Protein export_Homo sapiens_hsa030600.92793475
53Nicotine addiction_Homo sapiens_hsa050330.92084005
54Taste transduction_Homo sapiens_hsa047420.90895604
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85967739
56Fatty acid biosynthesis_Homo sapiens_hsa000610.83427744
57Thyroid cancer_Homo sapiens_hsa052160.82808185
58Fatty acid metabolism_Homo sapiens_hsa012120.81573966
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.81536511
60Bladder cancer_Homo sapiens_hsa052190.80836387
61Olfactory transduction_Homo sapiens_hsa047400.79794635
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77599553
63Pentose phosphate pathway_Homo sapiens_hsa000300.75717214
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75316958
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75171687
66Adherens junction_Homo sapiens_hsa045200.75115361
67Fanconi anemia pathway_Homo sapiens_hsa034600.73802302
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72332923
69Complement and coagulation cascades_Homo sapiens_hsa046100.71939651
70Biosynthesis of amino acids_Homo sapiens_hsa012300.70722896
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.70720409
72Chemical carcinogenesis_Homo sapiens_hsa052040.69973967
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69361324
74Serotonergic synapse_Homo sapiens_hsa047260.69067430
75beta-Alanine metabolism_Homo sapiens_hsa004100.67208381
76Thyroid hormone synthesis_Homo sapiens_hsa049180.66662736
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63221813
78Fatty acid elongation_Homo sapiens_hsa000620.62891835
79Oxidative phosphorylation_Homo sapiens_hsa001900.60205150
80Ovarian steroidogenesis_Homo sapiens_hsa049130.57791116
81Insulin secretion_Homo sapiens_hsa049110.54905951
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.54848698
83Gastric acid secretion_Homo sapiens_hsa049710.53863965
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53312834
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51343153
86Collecting duct acid secretion_Homo sapiens_hsa049660.50862489
87Tyrosine metabolism_Homo sapiens_hsa003500.48996188
88Morphine addiction_Homo sapiens_hsa050320.48449552
89Selenocompound metabolism_Homo sapiens_hsa004500.46905991
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45033589
91Retinol metabolism_Homo sapiens_hsa008300.44636791
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43766246
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43448309
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42253596
95Basal transcription factors_Homo sapiens_hsa030220.42208513
96Peroxisome_Homo sapiens_hsa041460.42157413
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.40934076
98Propanoate metabolism_Homo sapiens_hsa006400.40611640
99Non-homologous end-joining_Homo sapiens_hsa034500.39847763
100Butanoate metabolism_Homo sapiens_hsa006500.39102418
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38983129
102Asthma_Homo sapiens_hsa053100.38272485
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37294048
104Lysine degradation_Homo sapiens_hsa003100.36977538
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36586063
106Vibrio cholerae infection_Homo sapiens_hsa051100.35280638
107One carbon pool by folate_Homo sapiens_hsa006700.34538624
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34126119
109Hepatitis C_Homo sapiens_hsa051600.33516143
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33348211
111Glutamatergic synapse_Homo sapiens_hsa047240.33175334
112RNA polymerase_Homo sapiens_hsa030200.32413155
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.32253932
114Steroid biosynthesis_Homo sapiens_hsa001000.31520820
115Type II diabetes mellitus_Homo sapiens_hsa049300.31330452
116Endometrial cancer_Homo sapiens_hsa052130.31266412
117Cocaine addiction_Homo sapiens_hsa050300.30640526
118Salmonella infection_Homo sapiens_hsa051320.30534838
119Sulfur relay system_Homo sapiens_hsa041220.30529487
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.30472046
121N-Glycan biosynthesis_Homo sapiens_hsa005100.29055695
122Arachidonic acid metabolism_Homo sapiens_hsa005900.28839339
123Circadian entrainment_Homo sapiens_hsa047130.28094081
124Purine metabolism_Homo sapiens_hsa002300.27065339
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26276504
126Small cell lung cancer_Homo sapiens_hsa052220.26200887
127Focal adhesion_Homo sapiens_hsa045100.26111079
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.25168448
129RNA degradation_Homo sapiens_hsa030180.24944245
130Inositol phosphate metabolism_Homo sapiens_hsa005620.24706216
131ECM-receptor interaction_Homo sapiens_hsa045120.24110406
132Salivary secretion_Homo sapiens_hsa049700.23222410
133Insulin resistance_Homo sapiens_hsa049310.21843832
134Renin secretion_Homo sapiens_hsa049240.19518916
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.19303026
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18159777
137Amoebiasis_Homo sapiens_hsa051460.17623600
138African trypanosomiasis_Homo sapiens_hsa051430.17443909
139Hippo signaling pathway_Homo sapiens_hsa043900.16987290
140Metabolic pathways_Homo sapiens_hsa011000.16885178
141Phenylalanine metabolism_Homo sapiens_hsa003600.16154027
142Proteoglycans in cancer_Homo sapiens_hsa052050.14931638

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