ANXA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.85971516
2Golgi transport vesicle coating (GO:0048200)4.89937559
3COPI coating of Golgi vesicle (GO:0048205)4.89937559
4desmosome organization (GO:0002934)4.79039227
5protein localization to endosome (GO:0036010)4.35491512
6cell adhesion mediated by integrin (GO:0033627)4.33235614
7wound healing, spreading of epidermal cells (GO:0035313)4.18611558
8negative regulation of nitric-oxide synthase activity (GO:0051001)3.87272929
9cellular response to interferon-alpha (GO:0035457)3.76654939
10skin morphogenesis (GO:0043589)3.73533265
11endodermal cell differentiation (GO:0035987)3.65397353
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56943557
13protein retention in ER lumen (GO:0006621)3.54021376
14wound healing, spreading of cells (GO:0044319)3.49039787
15muscle cell migration (GO:0014812)3.41558990
16chondrocyte proliferation (GO:0035988)3.36338017
17regulation of transforming growth factor beta2 production (GO:0032909)3.35541645
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.33250408
19* collagen fibril organization (GO:0030199)3.26221668
20neutrophil activation involved in immune response (GO:0002283)3.25084122
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.23200863
22type B pancreatic cell proliferation (GO:0044342)3.18322631
23negative regulation of anoikis (GO:2000811)3.17570108
24protein maturation by protein folding (GO:0022417)3.16147933
25regulation of integrin-mediated signaling pathway (GO:2001044)3.15442599
26protein heterotrimerization (GO:0070208)3.13807898
27extracellular fibril organization (GO:0043206)3.12141072
28nucleotide-sugar biosynthetic process (GO:0009226)3.08755975
29UDP-N-acetylglucosamine metabolic process (GO:0006047)3.06660046
30regulation of interleukin-8 secretion (GO:2000482)3.06456175
31regulation of monocyte chemotaxis (GO:0090025)3.06028645
32low-density lipoprotein particle clearance (GO:0034383)3.04760123
33proteasome assembly (GO:0043248)3.03334699
34hypotonic response (GO:0006971)3.02182983
35positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.97415360
36positive regulation of monocyte chemotaxis (GO:0090026)2.97413161
37cellular response to zinc ion (GO:0071294)2.95483951
38negative regulation of nitric oxide biosynthetic process (GO:0045019)2.92738688
39cellular copper ion homeostasis (GO:0006878)2.92716058
40cell-substrate junction assembly (GO:0007044)2.91843384
41collagen metabolic process (GO:0032963)2.90824990
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.89925601
43protein hydroxylation (GO:0018126)2.89720044
44COPII vesicle coating (GO:0048208)2.87861481
45nucleobase-containing small molecule interconversion (GO:0015949)2.87644199
46epithelial cell-cell adhesion (GO:0090136)2.86886303
47apoptotic cell clearance (GO:0043277)2.85921316
48positive regulation of actin filament depolymerization (GO:0030836)2.84478667
49mesenchymal-epithelial cell signaling (GO:0060638)2.81193302
50fibril organization (GO:0097435)2.80347351
51collagen catabolic process (GO:0030574)2.79104429
52negative regulation of keratinocyte proliferation (GO:0010839)2.78594495
53negative regulation of fatty acid transport (GO:2000192)2.78446038
54extracellular matrix disassembly (GO:0022617)2.77721195
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77124705
56basement membrane organization (GO:0071711)2.75707348
57multicellular organismal macromolecule metabolic process (GO:0044259)2.74648342
58mesodermal cell differentiation (GO:0048333)2.74611856
59regulation of anoikis (GO:2000209)2.73329286
60glomerular visceral epithelial cell development (GO:0072015)2.72522034
61regulation of apoptotic process involved in morphogenesis (GO:1902337)2.71943775
62positive regulation of natural killer cell differentiation (GO:0032825)2.71811521
63keratinocyte differentiation (GO:0030216)2.71589921
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70986199
65negative regulation of stem cell proliferation (GO:2000647)2.70156621
66endothelial cell morphogenesis (GO:0001886)2.69999559
67regulation of transforming growth factor beta1 production (GO:0032908)2.69776203
68positive regulation of blood vessel endothelial cell migration (GO:0043536)2.69302125
69negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.68781707
70positive regulation of extracellular matrix organization (GO:1903055)2.64639657
71lipopolysaccharide biosynthetic process (GO:0009103)2.64540402
72pinocytosis (GO:0006907)2.63276970
73sprouting angiogenesis (GO:0002040)2.63095978
74multicellular organismal catabolic process (GO:0044243)2.61416240
75multicellular organismal metabolic process (GO:0044236)2.60927442
76regulation of chemokine secretion (GO:0090196)2.60616238
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.59856918
78ventricular cardiac muscle cell development (GO:0055015)2.59700073
79keratinocyte proliferation (GO:0043616)2.59227449
80membrane protein ectodomain proteolysis (GO:0006509)2.59046627
81positive regulation of osteoblast proliferation (GO:0033690)2.58269778
82cell migration involved in heart development (GO:0060973)2.57895512
83cellular response to vitamin (GO:0071295)2.57523263
84ganglion development (GO:0061548)2.57399454
85kidney mesenchyme development (GO:0072074)2.56903835
86vesicle coating (GO:0006901)2.54507632
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53367212
88positive regulation of focal adhesion assembly (GO:0051894)2.51562404
89positive regulation of cell junction assembly (GO:1901890)2.51562404
90peptide cross-linking (GO:0018149)2.49952242
91hyaluronan catabolic process (GO:0030214)2.48558555
92dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48527806
93positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.46698963
94sequestering of extracellular ligand from receptor (GO:0035581)2.46657195
95negative regulation of cartilage development (GO:0061037)2.46452527
96protein localization to cell surface (GO:0034394)2.46009011
97negative regulation of interleukin-8 production (GO:0032717)2.45794716
98glomerular epithelial cell development (GO:0072310)2.45698940
99mitotic nuclear envelope reassembly (GO:0007084)2.45184174
100nuclear envelope reassembly (GO:0031468)2.45184174
101regulation of water loss via skin (GO:0033561)2.43454918
102positive regulation of epithelial cell migration (GO:0010634)2.43390067
103response to gravity (GO:0009629)2.43300338
104* membrane raft organization (GO:0031579)2.43040881
105barbed-end actin filament capping (GO:0051016)2.43014035
106positive regulation of adherens junction organization (GO:1903393)2.42784581
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42177985
108regulation of tight junction assembly (GO:2000810)2.42067108
109negative regulation of monooxygenase activity (GO:0032769)2.39714072
110hepatocyte apoptotic process (GO:0097284)2.38195734
111regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37074597
112positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36111232
113response to interferon-alpha (GO:0035455)2.35428829
114sequestering of actin monomers (GO:0042989)2.33977566
115regulation of mononuclear cell migration (GO:0071675)2.33495653
116plasma membrane repair (GO:0001778)2.32682184
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.32373856
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31744814
119glomerular basement membrane development (GO:0032836)2.30962733
120intermediate filament organization (GO:0045109)2.30598459
121interferon-gamma secretion (GO:0072643)2.29491346
122positive regulation of chemokine secretion (GO:0090197)2.27817079
123myeloid cell homeostasis (GO:0002262)2.27041597
124regulation of metalloenzyme activity (GO:0048552)2.26718031
125keratan sulfate catabolic process (GO:0042340)2.26697115
126substrate adhesion-dependent cell spreading (GO:0034446)2.26414917
127positive regulation of epithelial to mesenchymal transition (GO:0010718)2.25563048
128regulation of podosome assembly (GO:0071801)2.25514833
129substrate-dependent cell migration (GO:0006929)2.23931977
130atrioventricular valve morphogenesis (GO:0003181)2.23783775
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.23671246
132axon extension involved in axon guidance (GO:0048846)2.23184982
133neuron projection extension involved in neuron projection guidance (GO:1902284)2.23184982
134cellular response to vitamin D (GO:0071305)2.22543707
135negative regulation of smooth muscle cell migration (GO:0014912)2.22374945
136fibroblast migration (GO:0010761)2.22242229
137vascular endothelial growth factor signaling pathway (GO:0038084)2.22232007
138natural killer cell mediated immunity (GO:0002228)2.22168264
139natural killer cell mediated cytotoxicity (GO:0042267)2.22168264
140regulation of natural killer cell differentiation (GO:0032823)2.21065856
141positive regulation of interferon-alpha production (GO:0032727)2.20569209
142molting cycle (GO:0042303)2.20400536
143hair cycle (GO:0042633)2.20400536
144negative regulation of chondrocyte differentiation (GO:0032331)2.19798352
145neutrophil activation (GO:0042119)2.19564166
146granulocyte activation (GO:0036230)2.19516663
147actin filament depolymerization (GO:0030042)2.18897429
148adhesion of symbiont to host cell (GO:0044650)2.18247038
149virion attachment to host cell (GO:0019062)2.18247038
150renal filtration (GO:0097205)2.18126571
151peptidyl-proline hydroxylation (GO:0019511)2.16501072
152establishment of skin barrier (GO:0061436)2.16236515
153regulation of macrophage cytokine production (GO:0010935)2.15367257
154platelet aggregation (GO:0070527)2.14956799
155positive regulation of p38MAPK cascade (GO:1900745)2.14747760
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13540550
157positive regulation of chemokine biosynthetic process (GO:0045080)2.13160669

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.01601360
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.84155412
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.10039884
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.06967703
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80968728
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66465660
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.52828950
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47937341
9* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.44265132
10* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.44265132
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.32460986
12* CLOCK_20551151_ChIP-Seq_293T_Human2.28338010
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.27186588
14* CJUN_26792858_Chip-Seq_BT549_Human2.24370198
15* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21473303
16AR_21909140_ChIP-Seq_LNCAP_Human2.17441139
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.17232541
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.15447046
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.11498351
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10458322
21* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.06383766
22SOX2_20726797_ChIP-Seq_SW620_Human2.06289493
23TP63_17297297_ChIP-ChIP_HaCaT_Human10.2881874
24* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.94838695
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89823519
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.89492947
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86058215
28* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77679384
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77669169
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76820500
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.75691547
32JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75487244
33* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.68393826
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64340821
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.64186543
36* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.62146276
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61681944
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.60512186
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60297426
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.60245029
41* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58489023
42* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51700291
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50296725
44ATF3_27146783_Chip-Seq_COLON_Human1.49200221
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49118777
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47471038
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.44801679
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44791577
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44239155
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43001057
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43001057
52BRD4_25478319_ChIP-Seq_HGPS_Human1.41892268
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39496165
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.38475805
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36071523
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35389641
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.34842411
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.34735277
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31386846
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31271467
61UBF1/2_26484160_Chip-Seq_HMECs_Human1.30875890
62ELK1_19687146_ChIP-ChIP_HELA_Human1.28495323
63RACK7_27058665_Chip-Seq_MCF-7_Human1.28063422
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.26241343
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24570347
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21825126
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20858718
68* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19400613
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18283341
70* GATA4_25053715_ChIP-Seq_YYC3_Human1.16922641
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16654712
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16443270
73* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14220550
74* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13606794
75SOX17_20123909_ChIP-Seq_XEN_Mouse1.12260756
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.11320396
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10710330
78* KLF5_25053715_ChIP-Seq_YYC3_Human1.09879157
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09878083
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08048666
81FOXM1_23109430_ChIP-Seq_U2OS_Human1.06486168
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05939065
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05835741
84EOMES_21245162_ChIP-Seq_HESCs_Human1.04889262
85* TP53_18474530_ChIP-ChIP_U2OS_Human1.04428523
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04112462
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04056299
88* ELK1_22589737_ChIP-Seq_MCF10A_Human1.03999210
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02196738
90* GATA3_24758297_ChIP-Seq_MCF-7_Human1.01333363
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00231553
92* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00176357
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.99642301
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98365421
95ELF5_23300383_ChIP-Seq_T47D_Human0.98333306
96NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97968340
97TFEB_21752829_ChIP-Seq_HELA_Human0.97966404
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97691442
99* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97417307
100VDR_24787735_ChIP-Seq_THP-1_Human0.96007066
101DCP1A_22483619_ChIP-Seq_HELA_Human0.94438433
102GABP_17652178_ChIP-ChIP_JURKAT_Human0.94253559
103SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94042064
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93763759
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93762323
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.93660789
107* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92888193
108* TP63_23658742_ChIP-Seq_EP156T_Human0.90469998
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.90261934
110TP53_16413492_ChIP-PET_HCT116_Human0.90231437
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88715028
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.88706292
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88394679
114* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88244328
115ZNF263_19887448_ChIP-Seq_K562_Human0.88116303
116* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83408304
117* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.82220394
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.80488960
119TBX20_22080862_ChIP-Seq_HEART_Mouse0.80488960
120* MAF_26560356_Chip-Seq_TH1_Human0.79208557
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78767113
122VDR_24763502_ChIP-Seq_THP-1_Human0.76466345
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76237330
124TP53_22127205_ChIP-Seq_IMR90_Human0.74045163
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.73078141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.80789492
2MP0005275_abnormal_skin_tensile4.33261809
3MP0003705_abnormal_hypodermis_morpholog3.67802572
4MP0003191_abnormal_cellular_cholesterol3.15979874
5MP0003566_abnormal_cell_adhesion2.89961419
6MP0009780_abnormal_chondrocyte_physiolo2.63759490
7MP0004272_abnormal_basement_membrane2.62150245
8MP0005503_abnormal_tendon_morphology2.60642078
9MP0002060_abnormal_skin_morphology2.48397732
10MP0003279_aneurysm2.38378762
11MP0001958_emphysema2.33466775
12MP0002796_impaired_skin_barrier2.25258246
13MP0010352_gastrointestinal_tract_polyps2.22406269
14MP0010234_abnormal_vibrissa_follicle2.16907271
15MP0005023_abnormal_wound_healing2.16132069
16MP0003941_abnormal_skin_development1.94102173
17MP0003436_decreased_susceptibility_to1.92461071
18MP0006054_spinal_hemorrhage1.85976797
19MP0003453_abnormal_keratinocyte_physiol1.83531876
20MP0002877_abnormal_melanocyte_morpholog1.74183692
21MP0002254_reproductive_system_inflammat1.72414756
22MP0005360_urolithiasis1.71711947
23MP0003091_abnormal_cell_migration1.65966457
24MP0009384_cardiac_valve_regurgitation1.63596897
25MP0004947_skin_inflammation1.63191255
26MP0003806_abnormal_nucleotide_metabolis1.61598577
27MP0001533_abnormal_skeleton_physiology1.61586203
28MP0001542_abnormal_bone_strength1.56797880
29MP0001216_abnormal_epidermal_layer1.55625406
30MP0005623_abnormal_meninges_morphology1.54267686
31MP0002148_abnormal_hypersensitivity_rea1.51789645
32MP0005501_abnormal_skin_physiology1.50782831
33MP0000858_altered_metastatic_potential1.46708038
34MP0010030_abnormal_orbit_morphology1.44254126
35MP0000749_muscle_degeneration1.43818500
36MP0001243_abnormal_dermal_layer1.43264452
37MP0005165_increased_susceptibility_to1.43228454
38MP0005508_abnormal_skeleton_morphology1.38694979
39MP0002282_abnormal_trachea_morphology1.38603778
40MP0002933_joint_inflammation1.38572037
41MP0005390_skeleton_phenotype1.37703962
42MP0009785_altered_susceptibility_to1.35552149
43MP0003448_altered_tumor_morphology1.35517637
44MP0000343_altered_response_to1.33504648
45MP0010771_integument_phenotype1.32006031
46MP0000383_abnormal_hair_follicle1.31157817
47MP0003724_increased_susceptibility_to1.27435468
48MP0001835_abnormal_antigen_presentation1.24340911
49MP0002998_abnormal_bone_remodeling1.21108399
50MP0009840_abnormal_foam_cell1.19902664
51MP0010678_abnormal_skin_adnexa1.19402352
52MP0005076_abnormal_cell_differentiation1.19082424
53MP0002295_abnormal_pulmonary_circulatio1.18796981
54MP0005257_abnormal_intraocular_pressure1.16571925
55MP0008004_abnormal_stomach_pH1.13792755
56MP0008260_abnormal_autophagy1.13407593
57MP0005595_abnormal_vascular_smooth1.13017527
58MP0001879_abnormal_lymphatic_vessel1.12621544
59MP0003950_abnormal_plasma_membrane1.11890813
60MP0009053_abnormal_anal_canal1.09923094
61MP0002419_abnormal_innate_immunity1.09224357
62MP0003300_gastrointestinal_ulcer1.06563295
63MP0000767_abnormal_smooth_muscle1.05744386
64MP0000762_abnormal_tongue_morphology1.05672710
65MP0005164_abnormal_response_to1.04764985
66MP0000733_abnormal_muscle_development1.04049241
67MP0003045_fibrosis1.03731581
68MP0005197_abnormal_uvea_morphology1.03693805
69MP0002896_abnormal_bone_mineralization1.03525869
70MP0004233_abnormal_muscle_weight1.03047925
71MP0000013_abnormal_adipose_tissue1.02778397
72MP0002006_tumorigenesis1.02768705
73MP0010368_abnormal_lymphatic_system1.00728867
74MP0009250_abnormal_appendicular_skeleto1.00513144
75MP0004782_abnormal_surfactant_physiolog0.99642058
76MP0005000_abnormal_immune_tolerance0.98449294
77MP0002166_altered_tumor_susceptibility0.98066993
78MP0000537_abnormal_urethra_morphology0.97893330
79MP0002405_respiratory_system_inflammati0.97617443
80MP0000377_abnormal_hair_follicle0.97499468
81MP0002098_abnormal_vibrissa_morphology0.97096846
82MP0005058_abnormal_lysosome_morphology0.95095710
83MP0003828_pulmonary_edema0.94913916
84MP0001346_abnormal_lacrimal_gland0.94532663
85MP0000685_abnormal_immune_system0.93774076
86MP0003303_peritoneal_inflammation0.93428703
87MP0000750_abnormal_muscle_regeneration0.93189574
88MP0003795_abnormal_bone_structure0.91128581
89MP0000163_abnormal_cartilage_morphology0.90579368
90MP0001849_ear_inflammation0.90556715
91MP0002332_abnormal_exercise_endurance0.90075767
92MP0010155_abnormal_intestine_physiology0.89553520
93MP0005025_abnormal_response_to0.89403658
94MP0000751_myopathy0.88953639
95MP0001851_eye_inflammation0.88648888
96MP0000627_abnormal_mammary_gland0.88440264
97MP0001853_heart_inflammation0.87449871
98MP0000427_abnormal_hair_cycle0.86787647
99MP0009931_abnormal_skin_appearance0.86533217
100MP0001191_abnormal_skin_condition0.86228060
101MP0000579_abnormal_nail_morphology0.85973627
102MP0002115_abnormal_skeleton_extremities0.85787387
103MP0000003_abnormal_adipose_tissue0.84002991
104MP0002113_abnormal_skeleton_development0.83840041
105MP0000647_abnormal_sebaceous_gland0.83293495
106MP0005193_abnormal_anterior_eye0.83081070
107MP0000467_abnormal_esophagus_morphology0.82829806
108MP0005408_hypopigmentation0.81963041
109MP0002234_abnormal_pharynx_morphology0.81856583
110MP0003075_altered_response_to0.81516697
111MP0001790_abnormal_immune_system0.81514103
112MP0005387_immune_system_phenotype0.81514103
113MP0003186_abnormal_redox_activity0.80377209
114MP0004185_abnormal_adipocyte_glucose0.79274309
115MP0004883_abnormal_blood_vessel0.78519063
116MP0002452_abnormal_antigen_presenting0.77876970
117MP0010386_abnormal_urinary_bladder0.77197549
118MP0000759_abnormal_skeletal_muscle0.75826196
119MP0001915_intracranial_hemorrhage0.75649983
120MP0002168_other_aberrant_phenotype0.75155903
121MP0001348_abnormal_lacrimal_gland0.74726464
122MP0005367_renal/urinary_system_phenotyp0.74434774
123MP0000516_abnormal_urinary_system0.74434774
124MP0001299_abnormal_eye_distance/0.73922254
125MP0009278_abnormal_bone_marrow0.73086268
126MP0005330_cardiomyopathy0.71390224
127MP0001881_abnormal_mammary_gland0.68160940
128MP0005621_abnormal_cell_physiology0.67074879
129MP0002177_abnormal_outer_ear0.64546513
130MP0009697_abnormal_copulation0.63323913
131MP0000358_abnormal_cell_content/0.63130384
132MP0002108_abnormal_muscle_morphology0.62801819
133MP0003755_abnormal_palate_morphology0.62112974
134MP0008007_abnormal_cellular_replicative0.60835267
135MP0000534_abnormal_ureter_morphology0.58291614
136* MP0001614_abnormal_blood_vessel0.57507591
137MP0005409_darkened_coat_color0.56768771
138MP0003385_abnormal_body_wall0.56450272

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.17316243
2Protrusio acetabuli (HP:0003179)4.79515706
3Atrophic scars (HP:0001075)4.58695111
4Reduced subcutaneous adipose tissue (HP:0003758)3.83146661
5Popliteal pterygium (HP:0009756)3.67713614
6Abnormality of placental membranes (HP:0011409)3.61167198
7Amniotic constriction ring (HP:0009775)3.61167198
8Spondylolisthesis (HP:0003302)3.57825437
9Osteolytic defects of the hand bones (HP:0009699)3.39482643
10Osteolytic defects of the phalanges of the hand (HP:0009771)3.39482643
11Cervical subluxation (HP:0003308)3.37526381
12Increased connective tissue (HP:0009025)3.28206570
13Vertebral compression fractures (HP:0002953)3.23479584
14Peritonitis (HP:0002586)3.20684274
15Milia (HP:0001056)3.15461854
16Fragile skin (HP:0001030)3.15372646
17Right ventricular cardiomyopathy (HP:0011663)3.11116298
18Ankle contracture (HP:0006466)3.03889315
19Glucose intolerance (HP:0000833)3.02920716
20Fragile nails (HP:0001808)2.98724030
21Aortic dissection (HP:0002647)2.98259918
22Short nail (HP:0001799)2.95816815
23Neonatal short-limb short stature (HP:0008921)2.89642554
24Spinal rigidity (HP:0003306)2.89482735
25Cardiovascular calcification (HP:0011915)2.88700376
26Alopecia of scalp (HP:0002293)2.85315928
27Thick nail (HP:0001805)2.82746602
28Wormian bones (HP:0002645)2.81134582
29Onycholysis (HP:0001806)2.81127364
30Dilatation of the ascending aorta (HP:0005111)2.79092659
31Aortic aneurysm (HP:0004942)2.75537825
32Soft skin (HP:0000977)2.74141716
33Follicular hyperkeratosis (HP:0007502)2.73932342
34Plantar hyperkeratosis (HP:0007556)2.69214690
35Shallow orbits (HP:0000586)2.65665456
36Distal lower limb muscle weakness (HP:0009053)2.65088974
37Abnormality of the distal phalanges of the toes (HP:0010182)2.61576082
38Entropion (HP:0000621)2.57690719
39Abnormality of dentin (HP:0010299)2.55151822
40Abnormalities of placenta or umbilical cord (HP:0001194)2.51395661
41Cerebral aneurysm (HP:0004944)2.49487673
42Mitral stenosis (HP:0001718)2.44848426
43Cupped ribs (HP:0000887)2.44744012
44Eczematoid dermatitis (HP:0000976)2.36334834
45Abnormality of the umbilical cord (HP:0010881)2.35786340
46Vascular calcification (HP:0004934)2.33411312
47Flat acetabular roof (HP:0003180)2.27432572
48Interstitial pulmonary disease (HP:0006530)2.19121177
49Generalized amyotrophy (HP:0003700)2.18979579
50Abnormality of liposaccharide metabolism (HP:0010968)2.17264318
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.17264318
52Abnormality of glycolipid metabolism (HP:0010969)2.17264318
53Blue sclerae (HP:0000592)2.17208472
54Type 1 muscle fiber predominance (HP:0003803)2.16275716
55Nail dystrophy (HP:0008404)2.15686306
56Coxa vara (HP:0002812)2.14214661
57Natal tooth (HP:0000695)2.13931905
58Epiphyseal dysplasia (HP:0002656)2.12493778
59Vascular tortuosity (HP:0004948)2.10363057
60Fatigable weakness (HP:0003473)2.10142656
61Abnormality of the neuromuscular junction (HP:0003398)2.10142656
62Abnormal hemoglobin (HP:0011902)2.09957487
63Delayed gross motor development (HP:0002194)2.09535078
64Aortic valve stenosis (HP:0001650)2.05749365
65Elbow flexion contracture (HP:0002987)2.05621240
66Microglossia (HP:0000171)2.01148865
67Beaking of vertebral bodies (HP:0004568)1.99971788
68Syringomyelia (HP:0003396)1.99754853
69Spinal cord lesions (HP:0100561)1.99754853
70Mitral regurgitation (HP:0001653)1.99209478
71Broad metatarsal (HP:0001783)1.98968575
72Abnormal glucose tolerance (HP:0001952)1.98627467
73Biconcave vertebral bodies (HP:0004586)1.98257847
74Woolly hair (HP:0002224)1.97799184
75Palmoplantar hyperkeratosis (HP:0000972)1.97669713
76Aortic regurgitation (HP:0001659)1.97490240
77Trismus (HP:0000211)1.96489415
78Abnormality of the acetabulum (HP:0003170)1.95082920
79Rough bone trabeculation (HP:0100670)1.94303048
80Pterygium (HP:0001059)1.94068248
81Mildly elevated creatine phosphokinase (HP:0008180)1.91414501
82Acanthosis nigricans (HP:0000956)1.90930566
83Hypotrichosis (HP:0001006)1.90781826
84Axonal loss (HP:0003447)1.90702498
85Mitral valve prolapse (HP:0001634)1.90487543
86Genu recurvatum (HP:0002816)1.89557003
87Ulnar bowing (HP:0003031)1.89237003
88Radial bowing (HP:0002986)1.88797016
89Platyspondyly (HP:0000926)1.88482649
90Orthostatic hypotension (HP:0001278)1.88012889
91Abnormality of carpal bone ossification (HP:0006257)1.87287500
92Distal lower limb amyotrophy (HP:0008944)1.84027792
93Abnormality of the 2nd finger (HP:0004100)1.83707389
94Recurrent abscess formation (HP:0002722)1.83221895
95Scapular winging (HP:0003691)1.82636039
96Aplasia of the musculature (HP:0100854)1.82432171
97Myocardial infarction (HP:0001658)1.82034549
98Wrist flexion contracture (HP:0001239)1.81044862
99Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.80772112
100Sparse eyelashes (HP:0000653)1.80566286
101Spinal cord compression (HP:0002176)1.80130588
102Hand muscle atrophy (HP:0009130)1.79827051
103Thin bony cortex (HP:0002753)1.79117957
104Palmar hyperkeratosis (HP:0010765)1.78797901
105Abnormal vertebral ossification (HP:0100569)1.78782898
106Arterial tortuosity (HP:0005116)1.77996722
107Osteoarthritis (HP:0002758)1.77775355
108Mesomelia (HP:0003027)1.76556279
109Ovoid vertebral bodies (HP:0003300)1.76037074
110Limb-girdle muscle atrophy (HP:0003797)1.74967967
111Broad face (HP:0000283)1.74865276
112Elevated erythrocyte sedimentation rate (HP:0003565)1.74429810
113Orchitis (HP:0100796)1.74189985
114Bladder diverticulum (HP:0000015)1.73447716
115Abnormality of the calcaneus (HP:0008364)1.73388840
116Nuclear cataract (HP:0100018)1.73321727
117Thoracolumbar scoliosis (HP:0002944)1.73167057
118Abnormality of oral frenula (HP:0000190)1.72744067
119Difficulty climbing stairs (HP:0003551)1.72412737
120Myositis (HP:0100614)1.71933787
121Camptodactyly of toe (HP:0001836)1.69901053
122Autoimmune thrombocytopenia (HP:0001973)1.69403062
123Subacute progressive viral hepatitis (HP:0006572)1.69392590
124Upper limb amyotrophy (HP:0009129)1.69284841
125Distal upper limb amyotrophy (HP:0007149)1.69284841
126Abnormal delivery (HP:0001787)1.69270788
127Asymmetry of the thorax (HP:0001555)1.67702414
128Femoral bowing (HP:0002980)1.67431140
129Abnormality of proline metabolism (HP:0010907)1.66878630
130Hydroxyprolinuria (HP:0003080)1.66878630
131Nemaline bodies (HP:0003798)1.66575595
132Advanced eruption of teeth (HP:0006288)1.66366905
133Delayed cranial suture closure (HP:0000270)1.65986974
134Pustule (HP:0200039)1.65850385
135Joint laxity (HP:0001388)1.65692223
136Absent frontal sinuses (HP:0002688)1.65517805
137Selective tooth agenesis (HP:0001592)1.65516350
138Abnormal foot bone ossification (HP:0010675)1.65193806
139Vertebral hypoplasia (HP:0008417)1.65038729
140Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.65038729
141Hematochezia (HP:0002573)1.64494432
142Abnormality of nail color (HP:0100643)1.64192808
143Tibial bowing (HP:0002982)1.63301434
144Joint stiffness (HP:0001387)1.62930623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.89596738
2TESK13.09143840
3MST1R2.86288557
4MAP3K32.81369749
5TRIB32.73076543
6TRPM72.68408466
7PIM22.57503410
8TTN2.54421614
9EPHA22.50953284
10MST42.44961818
11DDR22.28636306
12LIMK12.26456429
13LRRK22.16326917
14EIF2AK12.11813612
15ERBB32.06821669
16ERN12.03931106
17EPHB22.00225341
18NME21.95062549
19EIF2AK31.87649794
20MAP3K141.84200352
21NEK91.78338253
22FER1.75328711
23STK101.73289766
24ERBB41.72696232
25NEK11.68290448
26TBK11.65403914
27MAPKAPK31.62911666
28RPS6KA41.60301892
29RIPK11.53453323
30PTK61.45393747
31BLK1.45218366
32MET1.43000610
33LATS11.40593630
34MOS1.40275174
35PBK1.40144326
36PTK21.36966031
37TGFBR21.35959284
38PKN21.30948279
39CDK81.30569742
40FRK1.29370299
41MUSK1.29342966
42LATS21.29223983
43BUB11.29099351
44BMX1.25631087
45SIK31.21196752
46EPHB11.20100139
47PDK21.20034151
48PAK41.16067293
49EPHA31.14628432
50PDGFRA1.14139232
51MAP2K11.13754696
52JAK31.13390460
53SCYL21.12476188
54TYK21.12031736
55MAP3K21.11401958
56PRKG21.10228271
57TRIM281.08530169
58MAP2K31.06036549
59STK241.04836655
60STK31.04168412
61NTRK11.03361819
62RPS6KB21.02917641
63ILK1.01296716
64TESK20.99007109
65FLT30.97390548
66MAP3K110.97013485
67IKBKB0.93446935
68MAP2K20.93378316
69PAK20.91305983
70KDR0.86992056
71TGFBR10.84533324
72STK38L0.83420509
73MAPKAPK20.75392360
74JAK10.75210926
75MYLK0.71761595
76MELK0.71153069
77ABL20.70150464
78CSK0.70148253
79ROCK10.69361729
80GRK70.69324828
81MATK0.69181264
82FGFR30.68942195
83FGFR40.68554282
84CHUK0.68175901
85PTK2B0.65709133
86VRK20.62583850
87CDK60.62472005
88PIK3CG0.62218409
89BMPR20.62098952
90SIK10.60703801
91ZAP700.60107706
92PDGFRB0.59114411
93DAPK30.57831109
94IKBKE0.57015627
95FGFR10.56783842
96STK380.56575445
97PAK60.56566859
98BRSK20.55784578
99ARAF0.53782478
100DAPK10.53747121
101MAP3K80.53395864
102PIK3CA0.49965243
103LMTK20.49097652
104BRSK10.48659714
105DMPK0.48054825
106TAOK10.47786099
107PRKCI0.47585939
108EEF2K0.46089286
109PAK10.45773934
110NUAK10.44037150
111RIPK40.43955347
112ABL10.43429645
113PAK30.43359955
114STK160.42648428
115GSK3A0.42501322
116PLK20.41855322
117IRAK30.40857727
118TAOK20.40133061
119BCR0.40010985
120HCK0.37948578
121PRKD20.37369654
122INSR0.37238275
123PIM10.36745715
124MAP3K10.36509367
125TIE10.36476363
126IGF1R0.35880786
127CDK90.35631343
128ROCK20.35132954
129KSR10.34974904
130KIT0.33658826
131CAMK2D0.31957226
132EIF2AK20.31636269
133CAMK2G0.31244382
134ADRBK10.31103692
135ZAK0.31039905
136AURKB0.29765479
137PRKCE0.28285393
138PLK30.27523698
139AKT20.24642540

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.86890296
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.54947346
3Sulfur metabolism_Homo sapiens_hsa009202.46404036
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.25899843
5Malaria_Homo sapiens_hsa051442.14503251
6Leishmaniasis_Homo sapiens_hsa051402.10177918
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03429969
8Focal adhesion_Homo sapiens_hsa045102.02202646
9Adherens junction_Homo sapiens_hsa045201.99973636
10Amoebiasis_Homo sapiens_hsa051461.89396628
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86091539
12Shigellosis_Homo sapiens_hsa051311.85364408
13Proteoglycans in cancer_Homo sapiens_hsa052051.84517751
14Toxoplasmosis_Homo sapiens_hsa051451.81345575
15Viral myocarditis_Homo sapiens_hsa054161.78512784
16Salmonella infection_Homo sapiens_hsa051321.76658357
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.74541732
18Pertussis_Homo sapiens_hsa051331.72797872
19Legionellosis_Homo sapiens_hsa051341.72707812
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71418390
21Protein export_Homo sapiens_hsa030601.69947121
22Galactose metabolism_Homo sapiens_hsa000521.66708695
23TNF signaling pathway_Homo sapiens_hsa046681.65804344
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65014588
25Small cell lung cancer_Homo sapiens_hsa052221.63989801
26Graft-versus-host disease_Homo sapiens_hsa053321.61173173
27Phagosome_Homo sapiens_hsa041451.58124196
28Apoptosis_Homo sapiens_hsa042101.55777206
29Bladder cancer_Homo sapiens_hsa052191.52889359
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48699775
31Pentose phosphate pathway_Homo sapiens_hsa000301.46985439
32N-Glycan biosynthesis_Homo sapiens_hsa005101.37740551
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34273776
34Osteoclast differentiation_Homo sapiens_hsa043801.32248964
35Protein digestion and absorption_Homo sapiens_hsa049741.28299112
36TGF-beta signaling pathway_Homo sapiens_hsa043501.28173229
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27092543
38Tuberculosis_Homo sapiens_hsa051521.24455320
39Rheumatoid arthritis_Homo sapiens_hsa053231.24124708
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23984515
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20788482
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19867778
43Hippo signaling pathway_Homo sapiens_hsa043901.18845194
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.17641851
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15941365
46Allograft rejection_Homo sapiens_hsa053301.14678406
47p53 signaling pathway_Homo sapiens_hsa041151.13250154
48Hematopoietic cell lineage_Homo sapiens_hsa046401.12514174
49Lysosome_Homo sapiens_hsa041421.10528980
50Fructose and mannose metabolism_Homo sapiens_hsa000511.08868665
51Chronic myeloid leukemia_Homo sapiens_hsa052201.08499552
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08253181
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07109141
54Fatty acid elongation_Homo sapiens_hsa000621.05796066
55MicroRNAs in cancer_Homo sapiens_hsa052061.04148552
56Influenza A_Homo sapiens_hsa051641.02804087
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.02775265
58Antigen processing and presentation_Homo sapiens_hsa046121.02643237
59Thyroid cancer_Homo sapiens_hsa052161.02518137
60Platelet activation_Homo sapiens_hsa046111.02157948
61Measles_Homo sapiens_hsa051621.01891152
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01841828
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.01627834
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98950245
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98946111
66Mineral absorption_Homo sapiens_hsa049780.96572818
67Tight junction_Homo sapiens_hsa045300.95259977
68Pancreatic cancer_Homo sapiens_hsa052120.95087886
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92083738
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92003332
71Hepatitis B_Homo sapiens_hsa051610.91074449
72Folate biosynthesis_Homo sapiens_hsa007900.90144745
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89438530
74Steroid biosynthesis_Homo sapiens_hsa001000.88551768
75Complement and coagulation cascades_Homo sapiens_hsa046100.85312813
76Proteasome_Homo sapiens_hsa030500.84210530
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82092278
78Vitamin B6 metabolism_Homo sapiens_hsa007500.81819073
79Staphylococcus aureus infection_Homo sapiens_hsa051500.81677606
80Hepatitis C_Homo sapiens_hsa051600.80158581
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79889916
82Arachidonic acid metabolism_Homo sapiens_hsa005900.79523202
83HIF-1 signaling pathway_Homo sapiens_hsa040660.79301987
84Nucleotide excision repair_Homo sapiens_hsa034200.78175029
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78113468
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77928857
87Sphingolipid metabolism_Homo sapiens_hsa006000.77537990
88VEGF signaling pathway_Homo sapiens_hsa043700.77260328
89Melanoma_Homo sapiens_hsa052180.75198778
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.75181779
91Pyrimidine metabolism_Homo sapiens_hsa002400.74724341
92HTLV-I infection_Homo sapiens_hsa051660.74671515
93Renin-angiotensin system_Homo sapiens_hsa046140.73238212
94Pathways in cancer_Homo sapiens_hsa052000.73084324
95Dilated cardiomyopathy_Homo sapiens_hsa054140.71539831
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.71366789
97Glutathione metabolism_Homo sapiens_hsa004800.71104026
98Biosynthesis of amino acids_Homo sapiens_hsa012300.70104621
99Carbon metabolism_Homo sapiens_hsa012000.67597294
100Pyruvate metabolism_Homo sapiens_hsa006200.66184879
101Autoimmune thyroid disease_Homo sapiens_hsa053200.65151935
102Rap1 signaling pathway_Homo sapiens_hsa040150.64645781
103Viral carcinogenesis_Homo sapiens_hsa052030.62952842
104Ribosome_Homo sapiens_hsa030100.62802396
105Prostate cancer_Homo sapiens_hsa052150.62717032
106Endocytosis_Homo sapiens_hsa041440.62287710
107Acute myeloid leukemia_Homo sapiens_hsa052210.61219849
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59997374
109Chemokine signaling pathway_Homo sapiens_hsa040620.59724140
110African trypanosomiasis_Homo sapiens_hsa051430.58171742
111Caffeine metabolism_Homo sapiens_hsa002320.57587729
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57340327
113Other glycan degradation_Homo sapiens_hsa005110.56961663
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.55754524
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.55591214
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.55272670
117Basal cell carcinoma_Homo sapiens_hsa052170.53243635
118Vibrio cholerae infection_Homo sapiens_hsa051100.52984642
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52005997
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51653244
121Endometrial cancer_Homo sapiens_hsa052130.51598358
122Prolactin signaling pathway_Homo sapiens_hsa049170.50480628
123Herpes simplex infection_Homo sapiens_hsa051680.50464379
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.49165202
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49045534
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45056895
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44097615
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43997942
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40001638
130Renal cell carcinoma_Homo sapiens_hsa052110.34973737
131Axon guidance_Homo sapiens_hsa043600.34859397
132Starch and sucrose metabolism_Homo sapiens_hsa005000.33920430
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28019032
134Prion diseases_Homo sapiens_hsa050200.26674812
135Tyrosine metabolism_Homo sapiens_hsa003500.26580387
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26438660
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25293386
138Hedgehog signaling pathway_Homo sapiens_hsa043400.22359964
139Cell cycle_Homo sapiens_hsa041100.21345420

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