ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	7.51435328
2	cullin deneddylation (GO:0010388)	4.84143019
3	membrane raft organization (GO:0031579)	4.51350158
4	protein deneddylation (GO:0000338)	4.50286214
5	platelet dense granule organization (GO:0060155)	4.24869948
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.22382473
7	regulation of cellular amino acid metabolic process (GO:0006521)	3.71196324
8	regulation of metalloenzyme activity (GO:0048552)	3.68465060
9	membrane budding (GO:0006900)	3.68134166
10	protein heterotetramerization (GO:0051290)	3.67986753
11	multicellular organismal aging (GO:0010259)	3.55540963
12	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.50942652
13	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.47184394
14	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.46298090
15	signal peptide processing (GO:0006465)	3.43655928
16	regulation of integrin-mediated signaling pathway (GO:2001044)	3.41329299
17	response to redox state (GO:0051775)	3.41296490
18	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.38394158
19	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.38394158
20	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.38394158
21	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.35769816
22	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.35769816
23	lipopolysaccharide biosynthetic process (GO:0009103)	3.34526730
24	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.34466241
25	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.34116010
26	terpenoid biosynthetic process (GO:0016114)	3.26991811
27	negative regulation of protein localization to cell surface (GO:2000009)	3.25218013
28	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.23266491
29	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.23266491
30	ribonucleoprotein complex disassembly (GO:0032988)	3.21101067
31	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.20968691
32	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.16226416
33	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.14640550
34	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.14374027
35	negative regulation of ligase activity (GO:0051352)	3.14374027
36	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.13804509
37	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.11688254
38	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.07406017
39	protein maturation by protein folding (GO:0022417)	3.07174987
40	DNA deamination (GO:0045006)	3.06220550
41	organelle disassembly (GO:1903008)	3.05588460
42	pseudouridine synthesis (GO:0001522)	2.99714170
43	positive regulation of ligase activity (GO:0051351)	2.95451491
44	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.95147676
45	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.94607020
46	ribosome assembly (GO:0042255)	2.94132903
47	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.92790444
48	intestinal epithelial cell development (GO:0060576)	2.92562053
49	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.90894997
50	sprouting angiogenesis (GO:0002040)	2.88581633
51	cell adhesion mediated by integrin (GO:0033627)	2.86777655
52	regulation of interleukin-8 secretion (GO:2000482)	2.86625807
53	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.85524673
54	amino acid salvage (GO:0043102)	2.82531465
55	L-methionine salvage (GO:0071267)	2.82531465
56	L-methionine biosynthetic process (GO:0071265)	2.82531465
57	antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	2.80280004
58	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.79435304
59	negative regulation of signal transduction by p53 class mediator (GO:1901797)	2.77183624
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.74576222
61	ether lipid metabolic process (GO:0046485)	2.74127416
62	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.71291458
63	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.70905319
64	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.69053810
65	protein targeting to mitochondrion (GO:0006626)	2.66555309
66	chaperone-mediated protein transport (GO:0072321)	2.64581941
67	ganglion development (GO:0061548)	2.64364954
68	positive regulation of cell cycle arrest (GO:0071158)	2.64114522
69	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.63291685
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.63283073
71	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.61649462
72	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	2.60845560
73	keratan sulfate catabolic process (GO:0042340)	2.60473635
74	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.58527807
75	protein peptidyl-prolyl isomerization (GO:0000413)	2.58207084
76	vascular smooth muscle contraction (GO:0014829)	2.57622295
77	lipopolysaccharide metabolic process (GO:0008653)	2.57385492
78	anterograde synaptic vesicle transport (GO:0048490)	2.55282547
79	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.53392800
80	protein complex biogenesis (GO:0070271)	2.53018086
81	DNA double-strand break processing (GO:0000729)	2.52202257
82	response to xenobiotic stimulus (GO:0009410)	2.52056614
83	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.51082923
84	ATP synthesis coupled proton transport (GO:0015986)	2.51082923
85	regulation of cellular amine metabolic process (GO:0033238)	2.50305872
86	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)	2.48930004
87	wound healing, spreading of epidermal cells (GO:0035313)	2.48903094
88	negative regulation of nitric oxide biosynthetic process (GO:0045019)	2.48293031
89	endosome to melanosome transport (GO:0035646)	2.47320233
90	endosome to pigment granule transport (GO:0043485)	2.47320233
91	nucleotide transmembrane transport (GO:1901679)	2.46934777
92	tonic smooth muscle contraction (GO:0014820)	2.45940615
93	regulation of ligase activity (GO:0051340)	2.44110350
94	type B pancreatic cell proliferation (GO:0044342)	2.42953787
95	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.41337469
96	inositol phosphate-mediated signaling (GO:0048016)	2.38737991
97	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.37697140
98	response to gravity (GO:0009629)	2.37583590
99	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.37567190
100	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.37567190

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.04329345
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68025694
3	ELK1_19687146_ChIP-ChIP_HELA_Human	3.25054087
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.22688111
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.88563493
6	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.87186370
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.80037303
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.74255018
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.61102221
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60693428
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.41256870
12	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.34980804
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.23656352
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.19183535
15	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.12952480
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91043211
17	BRD4_25478319_ChIP-Seq_HGPS_Human	1.89788395
18	CJUN_26792858_Chip-Seq_BT549_Human	1.89011413
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.88308224
20	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.85824184
21	DCP1A_22483619_ChIP-Seq_HELA_Human	1.82532389
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.79810827
23	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.79523215
24	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.74722227
25	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.72773795
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.72732151
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.72181957
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.71730383
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68277729
30	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.64211440
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.62800561
32	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.56458904
33	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54372230
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.53576379
35	ZNF274_21170338_ChIP-Seq_K562_Hela	1.50772047
36	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.50715189
37	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.49950504
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.47617755
39	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.46638146
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.43612210
41	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.38256233
42	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.38256233
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33058797
44	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.32803475
45	* CDX2_22108803_ChIP-Seq_LS180_Human	1.29452986
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.28849377
47	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.26723042
48	* GATA4_25053715_ChIP-Seq_YYC3_Human	1.25988735
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25077684
50	P300_19829295_ChIP-Seq_ESCs_Human	1.24057329
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.22661256
52	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19258827
53	* AR_20517297_ChIP-Seq_VCAP_Human	1.18523349
54	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.18194252
55	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.18194252
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17578568
57	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.14732086
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14354191
59	SOX2_20726797_ChIP-Seq_SW620_Human	1.13403416
60	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09579115
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09293093
62	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.08474686
63	SMAD1_18555785_Chip-Seq_ESCs_Mouse	1.07888324
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07884188
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.07724838
66	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.07619902
67	EWS_26573619_Chip-Seq_HEK293_Human	1.06494742
68	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.06414761
69	TP53_16413492_ChIP-PET_HCT116_Human	1.05805082
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05753263
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05753263
72	P300_18555785_Chip-Seq_ESCs_Mouse	1.05335746
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05148273
74	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.04684348
75	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.04563387
76	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03919394
77	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.02698023
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02648474
79	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01146509
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00141570
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.99252877
82	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98912008
83	ZFX_18555785_Chip-Seq_ESCs_Mouse	0.98901321
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96234971
85	CBP_20019798_ChIP-Seq_JUKART_Human	0.96234971
86	TP53_18474530_ChIP-ChIP_U2OS_Human	0.95876604
87	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.95548482
88	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.95516495
89	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.95132313
90	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.94736378
91	OCT4_18555785_Chip-Seq_ESCs_Mouse	0.94503413
92	PU1_27457419_Chip-Seq_LIVER_Mouse	0.94353459
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94231910
94	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.91995019
95	ELF5_23300383_ChIP-Seq_T47D_Human	0.89278773
96	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.88482793
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.88326063
98	GATA3_26560356_Chip-Seq_TH2_Human	0.88198147
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.87500339
100	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.87357588

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006054_spinal_hemorrhage	5.69717143
2	MP0003950_abnormal_plasma_membrane	4.71476455
3	MP0008438_abnormal_cutaneous_collagen	3.86978035
4	MP0005171_absent_coat_pigmentation	3.81700919
5	MP0010368_abnormal_lymphatic_system	3.09098139
6	MP0003806_abnormal_nucleotide_metabolis	2.90540862
7	MP0001879_abnormal_lymphatic_vessel	2.33323698
8	MP0003191_abnormal_cellular_cholesterol	2.21849714
9	MP0004272_abnormal_basement_membrane	2.18248097
10	MP0005360_urolithiasis	2.12131244
11	MP0000372_irregular_coat_pigmentation	2.05951533
12	MP0003186_abnormal_redox_activity	1.98817638
13	MP0002254_reproductive_system_inflammat	1.97806320
14	MP0005623_abnormal_meninges_morphology	1.94761714
15	MP0002138_abnormal_hepatobiliary_system	1.92028536
16	MP0001849_ear_inflammation	1.87727907
17	MP0005408_hypopigmentation	1.87678241
18	MP0002933_joint_inflammation	1.77203973
19	MP0001542_abnormal_bone_strength	1.74975046
20	MP0005023_abnormal_wound_healing	1.72764504
21	MP0008875_abnormal_xenobiotic_pharmacok	1.72076015
22	MP0010386_abnormal_urinary_bladder	1.69135040
23	MP0005503_abnormal_tendon_morphology	1.66154497
24	MP0002148_abnormal_hypersensitivity_rea	1.62456992
25	MP0002095_abnormal_skin_pigmentation	1.61183479
26	MP0002938_white_spotting	1.60416854
27	MP0003252_abnormal_bile_duct	1.55337871
28	MP0006072_abnormal_retinal_apoptosis	1.51650877
29	MP0004084_abnormal_cardiac_muscle	1.51326525
30	MP0009785_altered_susceptibility_to	1.45640262
31	MP0005165_increased_susceptibility_to	1.44423231
32	MP0003786_premature_aging	1.43768837
33	MP0001243_abnormal_dermal_layer	1.43276492
34	MP0005167_abnormal_blood-brain_barrier	1.42365403
35	MP0009384_cardiac_valve_regurgitation	1.41770430
36	MP0000749_muscle_degeneration	1.40877086
37	MP0003279_aneurysm	1.37732822
38	MP0002877_abnormal_melanocyte_morpholog	1.34943099
39	MP0005084_abnormal_gallbladder_morpholo	1.31161804
40	MP0002102_abnormal_ear_morphology	1.29383378
41	MP0005275_abnormal_skin_tensile	1.24228461
42	MP0001958_emphysema	1.23887023
43	MP0005367_renal/urinary_system_phenotyp	1.22049624
44	MP0000516_abnormal_urinary_system	1.22049624
45	MP0001529_abnormal_vocalization	1.21705887
46	MP0008775_abnormal_heart_ventricle	1.20542940
47	MP0009764_decreased_sensitivity_to	1.20061972
48	MP0005595_abnormal_vascular_smooth	1.17464194
49	MP0005365_abnormal_bile_salt	1.16685500
50	MP0001756_abnormal_urination	1.15672333
51	MP0009697_abnormal_copulation	1.12637622
52	MP0003195_calcinosis	1.10914116
53	MP0001835_abnormal_antigen_presentation	1.10834191
54	MP0005253_abnormal_eye_physiology	1.10009578
55	MP0001853_heart_inflammation	1.08643032
56	MP0000015_abnormal_ear_pigmentation	1.08345432
57	MP0004215_abnormal_myocardial_fiber	1.06883526
58	MP0002090_abnormal_vision	1.05862809
59	MP0005083_abnormal_biliary_tract	1.02060526
60	MP0000647_abnormal_sebaceous_gland	1.01507741
61	MP0000613_abnormal_salivary_gland	0.97988057
62	MP0006138_congestive_heart_failure	0.94579351
63	MP0010234_abnormal_vibrissa_follicle	0.93802838
64	MP0000767_abnormal_smooth_muscle	0.92006391
65	MP0004484_altered_response_of	0.91770796
66	MP0005187_abnormal_penis_morphology	0.90736247
67	MP0002168_other_aberrant_phenotype	0.89018534
68	MP0001661_extended_life_span	0.87310910
69	MP0005332_abnormal_amino_acid	0.86722208
70	MP0000569_abnormal_digit_pigmentation	0.86689496
71	MP0003828_pulmonary_edema	0.85511482
72	MP0005085_abnormal_gallbladder_physiolo	0.85310768
73	MP0000733_abnormal_muscle_development	0.84748570
74	MP0003646_muscle_fatigue	0.84607301
75	MP0002736_abnormal_nociception_after	0.84103651
76	MP0000358_abnormal_cell_content/	0.82480805
77	MP0005058_abnormal_lysosome_morphology	0.82346076
78	MP0002177_abnormal_outer_ear	0.80091444
79	MP0002972_abnormal_cardiac_muscle	0.79934315
80	MP0002127_abnormal_cardiovascular_syste	0.79252369
81	MP0009053_abnormal_anal_canal	0.77477404
82	MP0000343_altered_response_to	0.77026552
83	MP0003566_abnormal_cell_adhesion	0.76237526
84	MP0002295_abnormal_pulmonary_circulatio	0.75007208
85	MP0004147_increased_porphyrin_level	0.74927073
86	MP0000762_abnormal_tongue_morphology	0.73553249
87	MP0002837_dystrophic_cardiac_calcinosis	0.72336999
88	MP0002163_abnormal_gland_morphology	0.71647799
89	MP0002060_abnormal_skin_morphology	0.71253106
90	MP0008873_increased_physiological_sensi	0.71018125
91	MP0005197_abnormal_uvea_morphology	0.68960061
92	MP0005164_abnormal_response_to	0.67943851
93	MP0004957_abnormal_blastocyst_morpholog	0.67584322
94	MP0000371_diluted_coat_color	0.66753965
95	MP0008789_abnormal_olfactory_epithelium	0.66473176
96	MP0004036_abnormal_muscle_relaxation	0.65038003
97	MP0002282_abnormal_trachea_morphology	0.62669275
98	MP0000537_abnormal_urethra_morphology	0.62411451
99	MP0005508_abnormal_skeleton_morphology	0.62335543
100	MP0002075_abnormal_coat/hair_pigmentati	0.62255848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of placental membranes (HP:0011409)	4.08516207
2	Amniotic constriction ring (HP:0009775)	4.08516207
3	Premature rupture of membranes (HP:0001788)	3.91228369
4	Cutaneous melanoma (HP:0012056)	3.84419024
5	Chorioretinal atrophy (HP:0000533)	3.10452930
6	Adrenal hypoplasia (HP:0000835)	3.04027018
7	Acute encephalopathy (HP:0006846)	2.92830959
8	Acute necrotizing encephalopathy (HP:0006965)	2.90362162
9	Increased CSF lactate (HP:0002490)	2.88627082
10	Reduced subcutaneous adipose tissue (HP:0003758)	2.87007339
11	Abnormality of proline metabolism (HP:0010907)	2.83759495
12	Hydroxyprolinuria (HP:0003080)	2.83759495
13	Hepatocellular necrosis (HP:0001404)	2.83544522
14	Congenital sensorineural hearing impairment (HP:0008527)	2.83455968
15	Mitochondrial inheritance (HP:0001427)	2.80199710
16	Vascular tortuosity (HP:0004948)	2.77018575
17	Congenital, generalized hypertrichosis (HP:0004540)	2.76614186
18	Albinism (HP:0001022)	2.75444728
19	Chronic diarrhea (HP:0002028)	2.74295672
20	Type I transferrin isoform profile (HP:0003642)	2.71398776
21	Aortic dissection (HP:0002647)	2.70004235
22	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.68088814
23	Osteolytic defects of the hand bones (HP:0009699)	2.65398188
24	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.65398188
25	Tongue fasciculations (HP:0001308)	2.65084444
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.60363575
27	Hepatic necrosis (HP:0002605)	2.59685700
28	Patchy hypopigmentation of hair (HP:0011365)	2.54071145
29	Mitral stenosis (HP:0001718)	2.51557500
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.49836931
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.49836931
32	Entropion (HP:0000621)	2.48676625
33	Metaphyseal dysplasia (HP:0100255)	2.48042953
34	Abnormal protein glycosylation (HP:0012346)	2.47522338
35	Abnormal glycosylation (HP:0012345)	2.47522338
36	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.47522338
37	Abnormal protein N-linked glycosylation (HP:0012347)	2.47522338
38	Mesomelia (HP:0003027)	2.47279992
39	Progressive macrocephaly (HP:0004481)	2.47112363
40	Parakeratosis (HP:0001036)	2.45031795
41	Short nail (HP:0001799)	2.44103155
42	Hypothermia (HP:0002045)	2.42789936
43	Arterial tortuosity (HP:0005116)	2.40595388
44	Abnormalities of placenta or umbilical cord (HP:0001194)	2.40449734
45	Hypokinesia (HP:0002375)	2.37970944
46	Keratoconus (HP:0000563)	2.33764355
47	Increased corneal curvature (HP:0100692)	2.33764355
48	Cerebral hemorrhage (HP:0001342)	2.33564214
49	Lipid accumulation in hepatocytes (HP:0006561)	2.33395999
50	Spinal muscular atrophy (HP:0007269)	2.32113769
51	Abnormality of the anterior horn cell (HP:0006802)	2.31475705
52	Degeneration of anterior horn cells (HP:0002398)	2.31475705
53	Methylmalonic aciduria (HP:0012120)	2.30144941
54	Aortic aneurysm (HP:0004942)	2.27999309
55	Hypoproteinemia (HP:0003075)	2.27821324
56	Glucose intolerance (HP:0000833)	2.27297626
57	Abolished electroretinogram (ERG) (HP:0000550)	2.25176864
58	Chronic mucocutaneous candidiasis (HP:0002728)	2.23583239
59	Recurrent cutaneous fungal infections (HP:0011370)	2.23583239
60	Increased hepatocellular lipid droplets (HP:0006565)	2.21651167
61	Methylmalonic acidemia (HP:0002912)	2.18237964
62	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.18141855
63	Cheilitis (HP:0100825)	2.17644772
64	Rough bone trabeculation (HP:0100670)	2.17295826
65	Disproportionate short-trunk short stature (HP:0003521)	2.13890924
66	Muscle fibrillation (HP:0010546)	2.13543252
67	Exertional dyspnea (HP:0002875)	2.11516991
68	Neonatal respiratory distress (HP:0002643)	2.11424548
69	Increased serum lactate (HP:0002151)	2.10696119
70	Facial diplegia (HP:0001349)	2.10196076
71	Hypoplasia of the uterus (HP:0000013)	2.03603916
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03410558
73	Ulnar claw (HP:0001178)	2.03120380
74	Sensory axonal neuropathy (HP:0003390)	2.02918946
75	Congenital ichthyosiform erythroderma (HP:0007431)	2.02148755
76	Submucous cleft hard palate (HP:0000176)	1.98582904
77	Redundant skin (HP:0001582)	1.98509605
78	Delayed gross motor development (HP:0002194)	1.97022416
79	Decreased muscle mass (HP:0003199)	1.94245017
80	Natal tooth (HP:0000695)	1.92745117
81	White forelock (HP:0002211)	1.89220722
82	Cerebral edema (HP:0002181)	1.88909896
83	Impaired proprioception (HP:0010831)	1.88526776
84	Nonimmune hydrops fetalis (HP:0001790)	1.87709668
85	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.84886120
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84385288
87	CNS demyelination (HP:0007305)	1.83986307
88	Lactic acidosis (HP:0003128)	1.82999648
89	Stillbirth (HP:0003826)	1.80713272
90	Follicular hyperkeratosis (HP:0007502)	1.80630561
91	Abnormality of the vocal cords (HP:0008777)	1.80076101
92	Abnormality of the distal phalanges of the toes (HP:0010182)	1.79861469
93	Respiratory failure (HP:0002878)	1.79587662
94	Testicular atrophy (HP:0000029)	1.78227765
95	Dry hair (HP:0011359)	1.76673101
96	Cardiovascular calcification (HP:0011915)	1.76348935
97	Vacuolated lymphocytes (HP:0001922)	1.75599066
98	Lethargy (HP:0001254)	1.75577836
99	Ovoid vertebral bodies (HP:0003300)	1.75488970
100	Short tibia (HP:0005736)	1.75360064

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K12	4.49634402
2	TIE1	4.00908906
3	MYLK	3.28674439
4	BMPR1B	3.25172795
5	MST4	2.81093416
6	NEK1	2.37805397
7	MST1R	2.36790463
8	TRIM28	2.19634310
9	EIF2AK3	2.17037151
10	PDK2	2.16539198
11	CDK8	2.14990877
12	STK39	2.13619402
13	MET	2.08974736
14	LIMK1	2.01804922
15	TGFBR1	2.00969659
16	PAK4	2.00694696
17	FRK	1.99902314
18	STK38L	1.84535454
19	ILK	1.84315389
20	LMTK2	1.83996974
21	EIF2AK1	1.68497676
22	TGFBR2	1.60396365
23	EPHA2	1.53491518
24	NUAK1	1.53216947
25	BMPR2	1.51062642
26	GRK1	1.50403620
27	PBK	1.49043620
28	SIK3	1.40553988
29	OXSR1	1.39084896
30	MAP4K2	1.34700741
31	ERBB4	1.33580523
32	ERBB3	1.32408647
33	SRPK1	1.31682008
34	SCYL2	1.29314516
35	VRK2	1.28121731
36	TLK1	1.28096744
37	BCR	1.27886828
38	WNK4	1.24232855
39	STK24	1.22299654
40	BUB1	1.21434438
41	PLK2	1.18647469
42	TESK1	1.17501281
43	ZAK	1.16352907
44	STK3	1.13641973
45	EPHB2	1.09530996
46	TXK	1.02520023
47	PLK3	1.02319885
48	DAPK1	1.00350004
49	ACVR1B	1.00025192
50	FLT3	0.97773527
51	MAP2K6	0.93189064
52	FER	0.91945432
53	LATS1	0.90677350
54	ROCK1	0.85141427
55	NME2	0.84138292
56	ADRBK2	0.80822013
57	RPS6KA4	0.80673750
58	TEC	0.78861432
59	PAK3	0.77713460
60	BCKDK	0.77692842
61	NEK9	0.77210551
62	ROCK2	0.71314750
63	CAMK2D	0.70216682
64	PRKCE	0.68395251
65	PTK2B	0.67849401
66	MOS	0.64929498
67	MUSK	0.64661704
68	MINK1	0.63804974
69	ABL2	0.62532127
70	MAPKAPK3	0.62291420
71	TRPM7	0.61775693
72	DAPK3	0.61501778
73	VRK1	0.59585289
74	MAP3K3	0.53718525
75	PIK3CG	0.50202794
76	GRK7	0.48957628
77	PTK2	0.47615578
78	PRKG2	0.46861015
79	IRAK3	0.45290667
80	PAK2	0.44635285
81	CAMK2G	0.44294770
82	CSNK1G3	0.42765783
83	CCNB1	0.41713283
84	CDK9	0.41293900
85	EGFR	0.38893191
86	STK16	0.38573273
87	ABL1	0.38014459
88	CDK7	0.37801609
89	EIF2AK2	0.37037691
90	IGF1R	0.33734426
91	MAP3K13	0.33693706
92	CSNK1A1L	0.32959985
93	CAMK2A	0.32564361
94	ADRBK1	0.31166645
95	IKBKB	0.30711532
96	WEE1	0.28259451
97	STK38	0.26256113
98	STK10	0.25605063
99	CSNK1G1	0.24655933
100	PRKG1	0.23029350

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.44748025
2	Protein export_Homo sapiens_hsa03060	3.86680584
3	Sulfur metabolism_Homo sapiens_hsa00920	3.36731734
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50821356
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.39510223
6	Caffeine metabolism_Homo sapiens_hsa00232	2.10003210
7	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.04474103
8	Parkinsons disease_Homo sapiens_hsa05012	1.97858901
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94846408
10	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.94461223
11	Basal transcription factors_Homo sapiens_hsa03022	1.79765981
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79690661
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.73516145
14	Vibrio cholerae infection_Homo sapiens_hsa05110	1.63910494
15	Glutathione metabolism_Homo sapiens_hsa00480	1.56154400
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.54623840
17	Folate biosynthesis_Homo sapiens_hsa00790	1.54139231
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.50057749
19	Asthma_Homo sapiens_hsa05310	1.46666201
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.45192506
21	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.44846546
22	Huntingtons disease_Homo sapiens_hsa05016	1.43484501
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41056967
24	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38781791
25	Collecting duct acid secretion_Homo sapiens_hsa04966	1.38617881
26	Alzheimers disease_Homo sapiens_hsa05010	1.34375907
27	RNA polymerase_Homo sapiens_hsa03020	1.30909230
28	Propanoate metabolism_Homo sapiens_hsa00640	1.25204100
29	Other glycan degradation_Homo sapiens_hsa00511	1.22830729
30	Sulfur relay system_Homo sapiens_hsa04122	1.20212948
31	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.19097166
32	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.18889652
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16783311
34	Regulation of autophagy_Homo sapiens_hsa04140	1.14008660
35	Nitrogen metabolism_Homo sapiens_hsa00910	1.08834635
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.05992489
37	Allograft rejection_Homo sapiens_hsa05330	1.05943786
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.03621252
39	RNA degradation_Homo sapiens_hsa03018	1.03501738
40	Graft-versus-host disease_Homo sapiens_hsa05332	1.03019564
41	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.02351514
42	One carbon pool by folate_Homo sapiens_hsa00670	1.00512597
43	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.99964904
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.97784359
45	Peroxisome_Homo sapiens_hsa04146	0.95915474
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95857544
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95561472
48	Shigellosis_Homo sapiens_hsa05131	0.91098674
49	Lysosome_Homo sapiens_hsa04142	0.90544439
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89208589
51	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.88249653
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.86872754
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.86850926
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85592468
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.84584133
56	Pyruvate metabolism_Homo sapiens_hsa00620	0.82183048
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.81675893
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80390767
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77857378
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75304498
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74361675
62	Mineral absorption_Homo sapiens_hsa04978	0.72011639
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.70566822
64	Fatty acid elongation_Homo sapiens_hsa00062	0.70175646
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67576690
66	p53 signaling pathway_Homo sapiens_hsa04115	0.67229877
67	Metabolic pathways_Homo sapiens_hsa01100	0.66952061
68	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.64491460
69	Tight junction_Homo sapiens_hsa04530	0.63581251
70	Phagosome_Homo sapiens_hsa04145	0.59935899
71	Viral myocarditis_Homo sapiens_hsa05416	0.59053396
72	Legionellosis_Homo sapiens_hsa05134	0.57559275
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51932294
74	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.51766113
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.51508476
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50691701
77	RNA transport_Homo sapiens_hsa03013	0.49816686
78	Purine metabolism_Homo sapiens_hsa00230	0.49464555
79	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.47884726
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.47834367
81	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.44716058
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44236912
83	Pertussis_Homo sapiens_hsa05133	0.42873310
84	Malaria_Homo sapiens_hsa05144	0.42604217
85	Endocytosis_Homo sapiens_hsa04144	0.41510065
86	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40377787
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.40309196
88	ECM-receptor interaction_Homo sapiens_hsa04512	0.39575880
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38427931
90	Complement and coagulation cascades_Homo sapiens_hsa04610	0.38195114
91	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37759130
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.35504910
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35315760
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35271904
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35172704
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34068602
97	Salmonella infection_Homo sapiens_hsa05132	0.32507219
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.32489778
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.32330794
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.32112298

ANXA2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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