ANXA2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.46041978
2cytidine metabolic process (GO:0046087)9.46041978
3cytidine catabolic process (GO:0006216)9.46041978
4DNA deamination (GO:0045006)9.16762459
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.55321641
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.28302905
7membrane raft organization (GO:0031579)5.87570347
8negative regulation of nitric-oxide synthase activity (GO:0051001)5.40339000
9eosinophil chemotaxis (GO:0048245)4.93515504
10regulation of cellular amino acid metabolic process (GO:0006521)4.68360759
11eosinophil migration (GO:0072677)4.44184794
12positive regulation of monocyte chemotaxis (GO:0090026)4.41618761
13regulation of activation of Janus kinase activity (GO:0010533)4.38525144
14Arp2/3 complex-mediated actin nucleation (GO:0034314)4.38456597
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.28480535
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23451563
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.21144334
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.16847192
19intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.15769656
20signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.15769656
21proteasome assembly (GO:0043248)4.14861695
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.10191555
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.10191555
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.10191555
25negative regulation of viral genome replication (GO:0045071)4.04756856
26sequestering of actin monomers (GO:0042989)4.02864136
27positive regulation of interleukin-8 secretion (GO:2000484)4.01825979
28antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.94229683
29pyrimidine nucleoside catabolic process (GO:0046135)3.90861856
30actin nucleation (GO:0045010)3.90514258
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.89124339
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.87152288
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.87152288
34negative regulation of ligase activity (GO:0051352)3.82937387
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82937387
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.80756068
37macrophage chemotaxis (GO:0048246)3.74951649
38regulation of interleukin-8 secretion (GO:2000482)3.72035978
39negative regulation of monooxygenase activity (GO:0032769)3.69035012
40negative regulation by host of viral transcription (GO:0043922)3.68360355
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65833077
42activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.65714751
43regulation of lymphocyte chemotaxis (GO:1901623)3.65573156
44regulation of sarcomere organization (GO:0060297)3.63494169
45negative regulation of T cell apoptotic process (GO:0070233)3.60932198
46T cell migration (GO:0072678)3.60618339
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53669279
48positive regulation of calcium-mediated signaling (GO:0050850)3.43849972
49regulation of chemokine-mediated signaling pathway (GO:0070099)3.43629736
50cytolysis (GO:0019835)3.42825798
51ATP synthesis coupled proton transport (GO:0015986)3.41103079
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.41103079
53positive regulation of cell cycle arrest (GO:0071158)3.40344525
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39062090
55platelet dense granule organization (GO:0060155)3.33136939
56regulation of cellular amine metabolic process (GO:0033238)3.31486243
57antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.29488064
58negative regulation of oxidoreductase activity (GO:0051354)3.26004404
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24013221
60protein neddylation (GO:0045116)3.21570935
61response to interferon-beta (GO:0035456)3.18122836
62establishment of protein localization to mitochondrial membrane (GO:0090151)3.15670510
63respiratory electron transport chain (GO:0022904)3.15560882
64regulation of skeletal muscle contraction (GO:0014819)3.14000571
65positive regulation of T cell chemotaxis (GO:0010820)3.12992640
66regulation of T cell chemotaxis (GO:0010819)3.12992640
67regulation of mononuclear cell migration (GO:0071675)3.08476610
68positive regulation of lymphocyte migration (GO:2000403)3.08474816
69electron transport chain (GO:0022900)3.08023724
70positive regulation of ligase activity (GO:0051351)3.06236123
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.05687241
72negative regulation of muscle hypertrophy (GO:0014741)3.03632452
73regulation of T cell tolerance induction (GO:0002664)3.01594757
74regulation of regulatory T cell differentiation (GO:0045589)3.00606955
75regulation of viral genome replication (GO:0045069)3.00063346
76DNA demethylation (GO:0080111)2.98525458
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.95056471
78termination of RNA polymerase III transcription (GO:0006386)2.95056471
79chaperone-mediated protein transport (GO:0072321)2.92107877
80lymphocyte chemotaxis (GO:0048247)2.90483583
81regulation of chronic inflammatory response (GO:0002676)2.87221491
82negative regulation of protein localization to cell surface (GO:2000009)2.86934658
83ribonucleoprotein complex disassembly (GO:0032988)2.86924482
84regulation of monocyte chemotaxis (GO:0090025)2.85658457
85positive regulation of defense response to virus by host (GO:0002230)2.81596182
86T cell costimulation (GO:0031295)2.80265181
87negative regulation of B cell proliferation (GO:0030889)2.79665260
88signal peptide processing (GO:0006465)2.78210177
89positive regulation of lamellipodium assembly (GO:0010592)2.77129529
90lymphocyte costimulation (GO:0031294)2.76608284
91positive thymic T cell selection (GO:0045059)2.72677800
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71886439
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71886439
94membrane budding (GO:0006900)2.71816981
95positive regulation of translational initiation (GO:0045948)2.71338889
96positive regulation of tolerance induction (GO:0002645)2.71184834
97regulation of calcium-mediated signaling (GO:0050848)2.70064520
98regulation of ubiquitin-protein transferase activity (GO:0051438)2.69847242
99pyrimidine ribonucleoside metabolic process (GO:0046131)2.69350483
100regulation of cell cycle arrest (GO:0071156)2.68949206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.52342721
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.83467813
3VDR_22108803_ChIP-Seq_LS180_Human3.67479153
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.65913449
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59636453
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.17481366
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11069764
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.79884323
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.74302504
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69357712
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.64805184
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54778624
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46496402
14ELK1_19687146_ChIP-ChIP_HELA_Human2.41640449
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.39900565
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35669571
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28483646
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21787181
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11008288
20ZNF274_21170338_ChIP-Seq_K562_Hela2.04294125
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.99281375
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96558589
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.93988033
24* VDR_23849224_ChIP-Seq_CD4+_Human1.91700688
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89608082
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.88949220
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85371135
28STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80480679
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73104400
30MYB_26560356_Chip-Seq_TH2_Human1.55157963
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50069124
32GATA3_26560356_Chip-Seq_TH2_Human1.50015434
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.49990513
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.44750612
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44498341
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39431011
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38769914
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.37277426
39FOXP3_21729870_ChIP-Seq_TREG_Human1.36669915
40GATA3_27048872_Chip-Seq_THYMUS_Human1.35112122
41HTT_18923047_ChIP-ChIP_STHdh_Human1.34883725
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34035575
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29648425
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29367910
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29294237
46NANOG_19829295_ChIP-Seq_ESCs_Human1.29014820
47SOX2_19829295_ChIP-Seq_ESCs_Human1.29014820
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28753869
49IGF1R_20145208_ChIP-Seq_DFB_Human1.25435372
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25353352
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24427844
52* AR_20517297_ChIP-Seq_VCAP_Human1.24424574
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21262175
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.21040007
55CJUN_26792858_Chip-Seq_BT549_Human1.19165386
56RUNX_20019798_ChIP-Seq_JUKART_Human1.19084485
57P300_19829295_ChIP-Seq_ESCs_Human1.16806405
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.15167366
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13642425
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13367898
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11726759
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11100056
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11022571
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.10332864
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10332864
66CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09581960
67EWS_26573619_Chip-Seq_HEK293_Human1.09329475
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09082532
69ER_23166858_ChIP-Seq_MCF-7_Human1.08768006
70BCAT_22108803_ChIP-Seq_LS180_Human1.08158766
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07162838
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06359291
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05670167
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.03381847
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02551600
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01478413
77ERG_20517297_ChIP-Seq_VCAP_Human1.01088023
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98799194
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.97025226
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.96495633
81CDX2_22108803_ChIP-Seq_LS180_Human0.96291179
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96028438
83NCOR_22424771_ChIP-Seq_293T_Human0.95047045
84TP53_22573176_ChIP-Seq_HFKS_Human0.94136772
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93852079
86* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93090028
87* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93089302
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92512901
89TAF2_19829295_ChIP-Seq_ESCs_Human0.92365271
90RBPJ_21746931_ChIP-Seq_IB4_Human0.91554490
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90890721
92* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90383082
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89680522
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.89197236
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88186629
96* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87629089
97SALL4_22934838_ChIP-ChIP_CD34+_Human0.86115133
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85617621
99SMAD1_18555785_Chip-Seq_ESCs_Mouse0.85336738
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83814857

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane6.77989010
2MP0005671_abnormal_response_to5.19976764
3MP0009785_altered_susceptibility_to3.88923825
4MP0006082_CNS_inflammation3.07354961
5MP0000749_muscle_degeneration2.95831422
6MP0001835_abnormal_antigen_presentation2.90640685
7MP0002102_abnormal_ear_morphology2.87589619
8MP0002148_abnormal_hypersensitivity_rea2.55246186
9MP0009333_abnormal_splenocyte_physiolog2.44061550
10MP0006054_spinal_hemorrhage2.39547896
11MP0002166_altered_tumor_susceptibility2.31138505
12MP0001853_heart_inflammation2.14172870
13MP0001873_stomach_inflammation2.13540675
14MP0001542_abnormal_bone_strength2.09673171
15MP0003763_abnormal_thymus_physiology2.01211421
16MP0002006_tumorigenesis2.01074235
17MP0005000_abnormal_immune_tolerance1.99481123
18MP0003806_abnormal_nucleotide_metabolis1.99052670
19MP0003448_altered_tumor_morphology1.89652156
20MP0002933_joint_inflammation1.87285213
21MP0000372_irregular_coat_pigmentation1.79342120
22MP0003786_premature_aging1.74000365
23MP0005025_abnormal_response_to1.72260818
24MP0004145_abnormal_muscle_electrophysio1.69978500
25MP0001800_abnormal_humoral_immune1.68753305
26MP0002723_abnormal_immune_serum1.68444648
27MP0002420_abnormal_adaptive_immunity1.64186765
28MP0001819_abnormal_immune_cell1.59302650
29MP0004883_abnormal_blood_vessel1.56149337
30MP0000685_abnormal_immune_system1.54797010
31MP0003045_fibrosis1.51206590
32MP0001790_abnormal_immune_system1.50558488
33MP0005387_immune_system_phenotype1.50558488
34MP0002452_abnormal_antigen_presenting1.47037912
35MP0004084_abnormal_cardiac_muscle1.46660632
36MP0002405_respiratory_system_inflammati1.45225303
37MP0008875_abnormal_xenobiotic_pharmacok1.44941637
38MP0003866_abnormal_defecation1.41820971
39MP0001845_abnormal_inflammatory_respons1.35231369
40MP0003011_delayed_dark_adaptation1.32955361
41MP0002163_abnormal_gland_morphology1.32079982
42MP0005084_abnormal_gallbladder_morpholo1.28690466
43MP0008438_abnormal_cutaneous_collagen1.15484630
44MP0010155_abnormal_intestine_physiology1.14845940
45MP0002837_dystrophic_cardiac_calcinosis1.14682801
46MP0008469_abnormal_protein_level1.14657592
47MP0005330_cardiomyopathy1.13797413
48MP0010386_abnormal_urinary_bladder1.12176975
49MP0000716_abnormal_immune_system1.11849790
50MP0009763_increased_sensitivity_to1.10601419
51MP0005166_decreased_susceptibility_to1.09613412
52MP0006072_abnormal_retinal_apoptosis1.05169263
53MP0001905_abnormal_dopamine_level1.04639338
54MP0005360_urolithiasis1.04007894
55MP0001919_abnormal_reproductive_system1.03279794
56MP0001485_abnormal_pinna_reflex1.03028039
57MP0003252_abnormal_bile_duct1.02007432
58MP0002876_abnormal_thyroid_physiology1.01361931
59MP0002419_abnormal_innate_immunity1.00061845
60MP0008872_abnormal_physiological_respon0.98920580
61MP0002138_abnormal_hepatobiliary_system0.98014560
62MP0000858_altered_metastatic_potential0.97823398
63MP0002398_abnormal_bone_marrow0.96249471
64MP0000751_myopathy0.92707342
65MP0003195_calcinosis0.90683901
66MP0002277_abnormal_respiratory_mucosa0.89838542
67MP0005253_abnormal_eye_physiology0.89738318
68MP0002234_abnormal_pharynx_morphology0.88032885
69MP0002972_abnormal_cardiac_muscle0.86422182
70MP0003137_abnormal_impulse_conducting0.85634637
71MP0005389_reproductive_system_phenotype0.84828019
72MP0009764_decreased_sensitivity_to0.84472342
73MP0005164_abnormal_response_to0.84208354
74MP0003279_aneurysm0.81699721
75MP0005275_abnormal_skin_tensile0.79830567
76MP0003186_abnormal_redox_activity0.79533513
77MP0002722_abnormal_immune_system0.78018953
78MP0004134_abnormal_chest_morphology0.77464178
79MP0003828_pulmonary_edema0.76658291
80MP0000689_abnormal_spleen_morphology0.76629746
81MP0002429_abnormal_blood_cell0.76191790
82MP0002095_abnormal_skin_pigmentation0.74975194
83MP0002282_abnormal_trachea_morphology0.72763683
84MP0005503_abnormal_tendon_morphology0.72644224
85MP0008789_abnormal_olfactory_epithelium0.70725429
86MP0003191_abnormal_cellular_cholesterol0.70247546
87MP0000639_abnormal_adrenal_gland0.69401191
88MP0005023_abnormal_wound_healing0.68612627
89MP0005319_abnormal_enzyme/_coenzyme0.68309834
90MP0004272_abnormal_basement_membrane0.67246443
91MP0006036_abnormal_mitochondrial_physio0.67190999
92MP0000569_abnormal_digit_pigmentation0.67151196
93MP0004036_abnormal_muscle_relaxation0.66695004
94MP0001661_extended_life_span0.65552375
95MP0001243_abnormal_dermal_layer0.63130185
96MP0009643_abnormal_urine_homeostasis0.62650557
97MP0000703_abnormal_thymus_morphology0.62599337
98MP0001764_abnormal_homeostasis0.62456349
99MP0005379_endocrine/exocrine_gland_phen0.62322091
100MP0000647_abnormal_sebaceous_gland0.61812232

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.43249074
2Hypoproteinemia (HP:0003075)4.30037218
3Type 2 muscle fiber atrophy (HP:0003554)4.26153535
4Amniotic constriction ring (HP:0009775)4.18859078
5Abnormality of placental membranes (HP:0011409)4.18859078
6T lymphocytopenia (HP:0005403)4.17907383
7Abnormality of T cell number (HP:0011839)4.06351432
8Mitochondrial inheritance (HP:0001427)3.88794870
9Acute necrotizing encephalopathy (HP:0006965)3.85719918
10Calf muscle hypertrophy (HP:0008981)3.68316787
11Muscle fiber atrophy (HP:0100295)3.66191253
12Abnormal mitochondria in muscle tissue (HP:0008316)3.45282989
13Hepatocellular necrosis (HP:0001404)3.44255415
14Exercise-induced muscle cramps (HP:0003710)3.43970147
15Progressive macrocephaly (HP:0004481)3.32566328
16Muscle hypertrophy of the lower extremities (HP:0008968)3.28530166
17Increased CSF lactate (HP:0002490)3.27410296
18IgG deficiency (HP:0004315)3.20781306
19Acute encephalopathy (HP:0006846)3.10472847
20Oral leukoplakia (HP:0002745)3.07090253
21Autoimmune hemolytic anemia (HP:0001890)3.06758787
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91394889
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91394889
24Hepatic necrosis (HP:0002605)2.88723932
25Elevated erythrocyte sedimentation rate (HP:0003565)2.83382748
26Cerebral edema (HP:0002181)2.80377667
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.75199778
28Hypoalbuminemia (HP:0003073)2.74668641
29Abnormal albumin level (HP:0012116)2.74668641
30Increased IgM level (HP:0003496)2.73446730
31Abnormality of T cells (HP:0002843)2.73035794
32Hypoplasia of the thymus (HP:0000778)2.71243166
33Popliteal pterygium (HP:0009756)2.69917241
34Reduced subcutaneous adipose tissue (HP:0003758)2.61145906
35Renal Fanconi syndrome (HP:0001994)2.57244947
36Chronic diarrhea (HP:0002028)2.57108959
37Increased hepatocellular lipid droplets (HP:0006565)2.53577448
38Abnormality of the prostate (HP:0008775)2.49917954
39Myotonia (HP:0002486)2.49317658
40Exercise-induced myalgia (HP:0003738)2.45187686
41Renal cortical cysts (HP:0000803)2.43742558
42Pancreatic cysts (HP:0001737)2.41216398
43Increased intramyocellular lipid droplets (HP:0012240)2.30192398
44Lipid accumulation in hepatocytes (HP:0006561)2.26847530
45Spondylolisthesis (HP:0003302)2.26667825
46Weak cry (HP:0001612)2.26230094
47Sudden death (HP:0001699)2.24377668
48Abnormality of the neuromuscular junction (HP:0003398)2.22332393
49Fatigable weakness (HP:0003473)2.22332393
50Pustule (HP:0200039)2.22034413
51Type I transferrin isoform profile (HP:0003642)2.20871134
52Neck muscle weakness (HP:0000467)2.20421789
53Aplasia/Hypoplasia involving the musculature (HP:0001460)2.19158449
54Eosinophilia (HP:0001880)2.17805536
55Palpitations (HP:0001962)2.17738673
56Abnormal rod and cone electroretinograms (HP:0008323)2.15873073
57Vascular tortuosity (HP:0004948)2.15790210
58Aortic dissection (HP:0002647)2.14409908
593-Methylglutaconic aciduria (HP:0003535)2.13012443
60Arterial tortuosity (HP:0005116)2.12645871
61Pancytopenia (HP:0001876)2.12101154
62Severe combined immunodeficiency (HP:0004430)2.10712071
63Respiratory failure (HP:0002878)2.09299516
64Gowers sign (HP:0003391)2.08598405
65True hermaphroditism (HP:0010459)2.08186560
66Posterior subcapsular cataract (HP:0007787)2.05508038
67Amyotrophic lateral sclerosis (HP:0007354)2.04711583
68Abnormality of eosinophils (HP:0001879)2.03784823
69Increased serum lactate (HP:0002151)2.03349320
70Abnormality of midbrain morphology (HP:0002418)2.02739456
71Molar tooth sign on MRI (HP:0002419)2.02739456
72Abolished electroretinogram (ERG) (HP:0000550)2.02275591
73Constricted visual fields (HP:0001133)2.02061899
74Recurrent cutaneous fungal infections (HP:0011370)1.99902320
75Chronic mucocutaneous candidiasis (HP:0002728)1.99902320
76Lactic acidosis (HP:0003128)1.98878330
77Pulmonary fibrosis (HP:0002206)1.96947937
78Keratoconus (HP:0000563)1.96900095
79Increased corneal curvature (HP:0100692)1.96900095
80Hepatosplenomegaly (HP:0001433)1.96109441
81Stomatitis (HP:0010280)1.92623307
82Thyroiditis (HP:0100646)1.92124863
83Exercise intolerance (HP:0003546)1.90293088
84Parakeratosis (HP:0001036)1.88316991
85Recurrent bronchitis (HP:0002837)1.87278780
86Nemaline bodies (HP:0003798)1.87063494
87Pancreatic fibrosis (HP:0100732)1.86689084
88Muscle stiffness (HP:0003552)1.85674126
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83059109
90Optic disc pallor (HP:0000543)1.81007916
91Exertional dyspnea (HP:0002875)1.80937188
92Abnormality of macrophages (HP:0004311)1.80457160
93Sparse eyelashes (HP:0000653)1.78640273
94Abnormality of the anterior horn cell (HP:0006802)1.78143666
95Degeneration of anterior horn cells (HP:0002398)1.78143666
96CNS demyelination (HP:0007305)1.77918511
97Increased muscle lipid content (HP:0009058)1.77887482
98Generalized aminoaciduria (HP:0002909)1.77778002
99Aplasia of the musculature (HP:0100854)1.76454983
100Pulmonary infiltrates (HP:0002113)1.76223498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.32020314
2MAP3K124.16452464
3TXK3.73749743
4VRK23.12936266
5BCKDK2.88939519
6TESK22.87567437
7MUSK2.83517340
8MST42.72020037
9EIF2AK32.51276706
10LIMK12.39193277
11MYLK2.25351743
12CDK82.22499066
13TESK12.11107516
14BUB12.08760380
15NUAK11.81801049
16TRIM281.78625300
17STK161.77705599
18MAPKAPK51.68810313
19VRK11.59928362
20PIK3CG1.57139099
21TIE11.51863925
22ITK1.38895351
23GRK71.32568346
24ADRBK21.31692748
25SCYL21.27953302
26BMPR21.27367793
27GRK11.23526662
28DAPK11.23237621
29BCR1.17638427
30PIK3CA1.12479372
31BMPR1B1.07510946
32MAP4K21.06949324
33ERBB31.05790521
34EIF2AK11.04088352
35PLK21.01317788
36ILK0.99835684
37NEK10.99107871
38INSRR0.97873856
39TGFBR20.94500873
40MAP4K10.91868617
41FRK0.90432774
42TEC0.90407959
43CCNB10.87598642
44OXSR10.86620472
45FES0.83149187
46PRKCQ0.82701990
47STK390.81255203
48PAK40.79953123
49PDK20.77725593
50ARAF0.76878923
51LCK0.76756315
52MAPKAPK30.76136415
53CSNK1G30.70556802
54SRPK10.69583264
55ROCK10.67889240
56CSK0.64421181
57PIM20.63557322
58STK100.60284509
59ZAK0.58627551
60MOS0.58138041
61PRKCE0.57307415
62GRK50.57072831
63PLK30.56627411
64IKBKB0.56426139
65DAPK30.55525759
66MELK0.54671931
67TAF10.53907453
68CSNK1G20.53808669
69CSNK1A1L0.53417828
70GRK60.53378985
71NME10.53370420
72SYK0.52165540
73MST1R0.51648535
74IGF1R0.50749051
75WNK40.50313318
76PAK10.49221191
77BLK0.47920020
78PAK30.47620943
79LYN0.46847188
80TNK20.46837562
81CSF1R0.44981812
82CSNK1G10.44930080
83MAP3K110.44296553
84CDK90.38996820
85OBSCN0.38513909
86ABL10.38402221
87INSR0.38315344
88CAMK2A0.38177053
89FGFR10.37639009
90TAOK30.36989960
91FER0.36826452
92ERBB40.36807760
93TRPM70.35759760
94PRKCA0.35077817
95CSNK2A10.34119432
96AURKA0.33944253
97MAP2K60.32754442
98EGFR0.32522560
99ZAP700.32029242
100EIF2AK20.31575819

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.17428446
2Primary immunodeficiency_Homo sapiens_hsa053403.44974891
3Oxidative phosphorylation_Homo sapiens_hsa001903.42508918
4Graft-versus-host disease_Homo sapiens_hsa053323.23214622
5Protein export_Homo sapiens_hsa030603.01933913
6Parkinsons disease_Homo sapiens_hsa050122.95482310
7Autoimmune thyroid disease_Homo sapiens_hsa053202.94460408
8Allograft rejection_Homo sapiens_hsa053302.78662901
9Antigen processing and presentation_Homo sapiens_hsa046122.69042924
10Rheumatoid arthritis_Homo sapiens_hsa053232.37073249
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27370730
12RNA polymerase_Homo sapiens_hsa030202.24759270
13Type I diabetes mellitus_Homo sapiens_hsa049402.10763528
14Alzheimers disease_Homo sapiens_hsa050102.03977119
15Asthma_Homo sapiens_hsa053101.88820300
16Hematopoietic cell lineage_Homo sapiens_hsa046401.85773713
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.77537531
18Caffeine metabolism_Homo sapiens_hsa002321.76504851
19Viral myocarditis_Homo sapiens_hsa054161.75673604
20Huntingtons disease_Homo sapiens_hsa050161.65884106
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65382071
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52996340
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.50546826
24Cardiac muscle contraction_Homo sapiens_hsa042601.48013374
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38309627
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.37167254
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35356602
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20623217
29Sulfur metabolism_Homo sapiens_hsa009201.13814246
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12401493
31T cell receptor signaling pathway_Homo sapiens_hsa046601.12074217
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09606281
33Salmonella infection_Homo sapiens_hsa051321.07691725
34Propanoate metabolism_Homo sapiens_hsa006401.00107083
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94674797
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90279455
37Collecting duct acid secretion_Homo sapiens_hsa049660.90102512
38Staphylococcus aureus infection_Homo sapiens_hsa051500.88451355
39Shigellosis_Homo sapiens_hsa051310.82973962
40Pyrimidine metabolism_Homo sapiens_hsa002400.82356950
41Phototransduction_Homo sapiens_hsa047440.76138946
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73730343
43Measles_Homo sapiens_hsa051620.73214192
44Nitrogen metabolism_Homo sapiens_hsa009100.72363872
45Peroxisome_Homo sapiens_hsa041460.68096512
46Fatty acid elongation_Homo sapiens_hsa000620.66075185
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.65494787
48Homologous recombination_Homo sapiens_hsa034400.63179293
49Glutathione metabolism_Homo sapiens_hsa004800.61923506
50Tryptophan metabolism_Homo sapiens_hsa003800.61107778
51Selenocompound metabolism_Homo sapiens_hsa004500.60533210
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58722997
53One carbon pool by folate_Homo sapiens_hsa006700.58330732
54Malaria_Homo sapiens_hsa051440.56054778
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54007153
56Legionellosis_Homo sapiens_hsa051340.53015999
57Pyruvate metabolism_Homo sapiens_hsa006200.52533195
58Basal transcription factors_Homo sapiens_hsa030220.52428481
59Chemical carcinogenesis_Homo sapiens_hsa052040.50879299
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48630049
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47668504
62Pertussis_Homo sapiens_hsa051330.47514256
63Mismatch repair_Homo sapiens_hsa034300.47129462
64Folate biosynthesis_Homo sapiens_hsa007900.46728351
65RNA degradation_Homo sapiens_hsa030180.46345567
66Nucleotide excision repair_Homo sapiens_hsa034200.44944428
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44939264
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44338881
69Purine metabolism_Homo sapiens_hsa002300.43104944
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42582502
71Regulation of autophagy_Homo sapiens_hsa041400.42362684
72Systemic lupus erythematosus_Homo sapiens_hsa053220.42025604
73Retinol metabolism_Homo sapiens_hsa008300.39884191
74Ribosome_Homo sapiens_hsa030100.38248787
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37682049
76Epstein-Barr virus infection_Homo sapiens_hsa051690.37351287
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.36630917
78Metabolic pathways_Homo sapiens_hsa011000.35619880
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35261747
80Phagosome_Homo sapiens_hsa041450.35042814
81Linoleic acid metabolism_Homo sapiens_hsa005910.33748136
82Vibrio cholerae infection_Homo sapiens_hsa051100.33580253
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.33222015
84Leishmaniasis_Homo sapiens_hsa051400.33020830
85beta-Alanine metabolism_Homo sapiens_hsa004100.31687410
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.30969546
87Herpes simplex infection_Homo sapiens_hsa051680.28064101
88Butanoate metabolism_Homo sapiens_hsa006500.27190731
89N-Glycan biosynthesis_Homo sapiens_hsa005100.27031238
90RNA transport_Homo sapiens_hsa030130.25925451
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25546136
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24971433
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.24911903
94DNA replication_Homo sapiens_hsa030300.24872187
95Olfactory transduction_Homo sapiens_hsa047400.24104325
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23989904
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.23085828
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22225413
99Tuberculosis_Homo sapiens_hsa051520.21502056
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21231052

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