ANXA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.10870988
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.94192062
3keratinocyte proliferation (GO:0043616)5.38825534
4negative regulation of keratinocyte proliferation (GO:0010839)5.13053730
5cell adhesion mediated by integrin (GO:0033627)4.95849134
6keratinocyte development (GO:0003334)4.59378476
7regulation of transforming growth factor beta2 production (GO:0032909)4.58275834
8ribosome assembly (GO:0042255)3.99288212
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90698742
10proteasome assembly (GO:0043248)3.90142268
11* neutrophil activation involved in immune response (GO:0002283)3.87620873
12cell-substrate junction assembly (GO:0007044)3.82622122
13protein autoprocessing (GO:0016540)3.81046260
14interferon-gamma secretion (GO:0072643)3.80852807
15wound healing, spreading of epidermal cells (GO:0035313)3.79108921
16gap junction assembly (GO:0016264)3.75585528
17intestinal epithelial cell development (GO:0060576)3.74570614
18natural killer cell mediated immunity (GO:0002228)3.53661985
19natural killer cell mediated cytotoxicity (GO:0042267)3.53661985
20regulation of water loss via skin (GO:0033561)3.52400143
21hepatocyte apoptotic process (GO:0097284)3.52303356
22regulation of keratinocyte proliferation (GO:0010837)3.49421522
23tight junction assembly (GO:0070830)3.47174120
24galactose catabolic process (GO:0019388)3.46543792
25positive regulation of hair cycle (GO:0042635)3.44737154
26positive regulation of hair follicle development (GO:0051798)3.44737154
27NIK/NF-kappaB signaling (GO:0038061)3.41640193
28response to peptidoglycan (GO:0032494)3.41102424
29diterpenoid biosynthetic process (GO:0016102)3.38854718
30regulation of hair follicle development (GO:0051797)3.31060345
31establishment of integrated proviral latency (GO:0075713)3.30434797
32establishment of skin barrier (GO:0061436)3.29258430
33response to muramyl dipeptide (GO:0032495)3.29232875
34positive regulation of interferon-alpha production (GO:0032727)3.26898439
35negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.26225648
36leukocyte mediated cytotoxicity (GO:0001909)3.26060615
37positive regulation of epidermis development (GO:0045684)3.24464595
38membrane budding (GO:0006900)3.23237693
39wound healing, spreading of cells (GO:0044319)3.23209629
40positive regulation of epidermal cell differentiation (GO:0045606)3.22994465
41regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22286687
42positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.14616153
43Arp2/3 complex-mediated actin nucleation (GO:0034314)3.12391203
44positive regulation of natural killer cell differentiation (GO:0032825)3.12235893
45negative regulation of chondrocyte differentiation (GO:0032331)3.10530557
46substrate-dependent cell migration (GO:0006929)3.09606557
47membrane raft organization (GO:0031579)3.09559570
48regulation of integrin-mediated signaling pathway (GO:2001044)3.07549283
49regulation of interferon-beta biosynthetic process (GO:0045357)3.06634379
50regulation of interferon-alpha production (GO:0032647)3.06256053
51regulation of cardioblast differentiation (GO:0051890)3.05244160
52* neutrophil activation (GO:0042119)3.05119642
53positive regulation of endothelial cell apoptotic process (GO:2000353)3.01155024
54Golgi transport vesicle coating (GO:0048200)3.00078946
55COPI coating of Golgi vesicle (GO:0048205)3.00078946
56positive regulation of monocyte chemotaxis (GO:0090026)2.99785494
57establishment of viral latency (GO:0019043)2.97118237
58positive regulation of Cdc42 GTPase activity (GO:0043089)2.95485718
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94531187
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.94531187
61modulation by symbiont of host immune response (GO:0052553)2.94531187
62positive regulation by symbiont of host defense response (GO:0052509)2.94531187
63modulation by symbiont of host defense response (GO:0052031)2.94531187
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94531187
65mesodermal cell differentiation (GO:0048333)2.94422879
66regulation of mononuclear cell migration (GO:0071675)2.92795688
67* granulocyte activation (GO:0036230)2.92294235
68hepatocyte differentiation (GO:0070365)2.92264817
69respiratory burst (GO:0045730)2.91068869
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90478745
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89213139
72regulation of hippo signaling (GO:0035330)2.88681021
73apoptotic cell clearance (GO:0043277)2.88471766
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.88469423
75hypotonic response (GO:0006971)2.87504116
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84137529
77lung lobe morphogenesis (GO:0060463)2.83979154
78hippo signaling (GO:0035329)2.83143788
79protein maturation by protein folding (GO:0022417)2.83011141
80regulation of cellular amino acid metabolic process (GO:0006521)2.80610010
81monocyte chemotaxis (GO:0002548)2.80336337
82nucleoside salvage (GO:0043174)2.79979701
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79812172
84regulation of monocyte chemotaxis (GO:0090025)2.79488508
85galactose metabolic process (GO:0006012)2.78551290
86endodermal cell differentiation (GO:0035987)2.78344964
87regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78168740
88macrophage activation involved in immune response (GO:0002281)2.77061142
89cell-cell junction assembly (GO:0007043)2.76650059
90terpenoid biosynthetic process (GO:0016114)2.76644337
91regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75961787
92positive regulation of actin filament depolymerization (GO:0030836)2.75870120
93protein heterotetramerization (GO:0051290)2.75136797
94response to fungus (GO:0009620)2.74733293
95neutrophil mediated immunity (GO:0002446)2.74653967
96regulation of T-helper 1 cell differentiation (GO:0045625)2.73677626
97positive regulation of osteoblast proliferation (GO:0033690)2.71388912
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.70685456
99positive regulation of chemokine secretion (GO:0090197)2.70118797
100regulation of antigen processing and presentation (GO:0002577)2.69776807
101plasma membrane repair (GO:0001778)2.68855686
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.68694861
103surfactant homeostasis (GO:0043129)2.68229967
104nucleobase-containing small molecule interconversion (GO:0015949)2.67992853
105positive regulation of antigen processing and presentation (GO:0002579)2.67234363
106myeloid leukocyte mediated immunity (GO:0002444)2.66951204
107negative regulation of interleukin-8 production (GO:0032717)2.66894756
108regulation of chemokine secretion (GO:0090196)2.66422718
109regulation of keratinocyte differentiation (GO:0045616)2.66167701
110cellular copper ion homeostasis (GO:0006878)2.65851043
111regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.65751518
112cellular response to zinc ion (GO:0071294)2.65455549
113regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.65414926
114positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65079365
115negative regulation of cartilage development (GO:0061037)2.63257254
116cellular response to interferon-alpha (GO:0035457)2.63239891
117negative regulation of ligase activity (GO:0051352)2.63041722
118negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63041722
119regulation of integrin activation (GO:0033623)2.62502074
120platelet aggregation (GO:0070527)2.62333845
121chronic inflammatory response (GO:0002544)2.61967520
122dendritic cell differentiation (GO:0097028)2.60887293
123ventricular cardiac muscle cell development (GO:0055015)2.59415959
124positive regulation of cellular amide metabolic process (GO:0034250)2.58260643
125production of molecular mediator involved in inflammatory response (GO:0002532)2.57594790
126negative regulation of stem cell proliferation (GO:2000647)2.56614217
127regulation of macrophage chemotaxis (GO:0010758)2.56146651
128positive regulation of macrophage differentiation (GO:0045651)2.55993323
129response to interferon-alpha (GO:0035455)2.55173987
130regulation of interleukin-12 biosynthetic process (GO:0045075)2.54453190
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54439064
132pinocytosis (GO:0006907)2.54086209
133establishment of endothelial barrier (GO:0061028)2.53978698
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.53937523
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.52838308
136protein localization to endosome (GO:0036010)2.51102559
137cell junction assembly (GO:0034329)2.50703515
138regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50494486
139pyrimidine-containing compound salvage (GO:0008655)2.49674737
140pyrimidine nucleoside salvage (GO:0043097)2.49674737
141chondrocyte proliferation (GO:0035988)2.49438384
142growth hormone receptor signaling pathway (GO:0060396)2.49432487
143chemical homeostasis within a tissue (GO:0048875)2.49203642
144positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48996753
145mitotic metaphase plate congression (GO:0007080)2.48330618
146regulation of epidermis development (GO:0045682)2.47745050
147molting cycle (GO:0042303)2.47337251
148hair cycle (GO:0042633)2.47337251
149epithelial cell-cell adhesion (GO:0090136)2.47156041
150myeloid dendritic cell differentiation (GO:0043011)2.46886262
151regulation of interleukin-8 secretion (GO:2000482)2.46815163
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.46256539
153ribosomal large subunit biogenesis (GO:0042273)2.45980537
154notochord development (GO:0030903)2.45608778
155DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.45235197
156immunoglobulin mediated immune response (GO:0016064)2.44842091
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.44325990
158positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.44278395
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42966122
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42966122
161actin nucleation (GO:0045010)2.42710287
162positive regulation of glycoprotein metabolic process (GO:1903020)2.42518663
163positive regulation of p38MAPK cascade (GO:1900745)2.42319322
164negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.42296861
165myeloid cell homeostasis (GO:0002262)2.42187358
166regulation of sulfur metabolic process (GO:0042762)2.42110106
167cell differentiation involved in embryonic placenta development (GO:0060706)2.42058054
168endothelial tube morphogenesis (GO:0061154)2.41779967
169morphogenesis of an endothelium (GO:0003159)2.41779967
170regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.41689100
171positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.41689100
172detection of molecule of bacterial origin (GO:0032490)2.40861919
173positive regulation of interleukin-12 production (GO:0032735)2.40174884
174regulation of metalloenzyme activity (GO:0048552)2.39089316
175myeloid dendritic cell activation (GO:0001773)2.37591561
176hyaluronan catabolic process (GO:0030214)2.36879938
177sequestering of actin monomers (GO:0042989)2.36286663
178microglial cell activation (GO:0001774)2.35639113
179positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.35480304
180cellular extravasation (GO:0045123)2.32818467
181skin morphogenesis (GO:0043589)2.32686952
182regulation of macrophage cytokine production (GO:0010935)2.32007125
183regulation of podosome assembly (GO:0071801)2.31991071
184antigen processing and presentation of endogenous antigen (GO:0019883)2.31967208
185regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.31195198
186hemidesmosome assembly (GO:0031581)2.30464725
187regulation of natural killer cell differentiation (GO:0032823)2.30257439
188dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30068912
189macrophage activation (GO:0042116)2.29959567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.28737193
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.30128214
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.89848812
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.86804697
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.78569637
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.75706503
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70234809
8RARG_19884340_ChIP-ChIP_MEFs_Mouse3.60597602
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.55021532
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20101250
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.06890177
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01859987
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.94822800
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.85286130
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81581097
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73871400
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68320778
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27984152
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25068379
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15850430
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.15533596
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.15533596
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14872878
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14088628
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04234112
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98043081
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95759531
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95222961
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.94310605
30ZNF263_19887448_ChIP-Seq_K562_Human1.94229192
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92745393
32CLOCK_20551151_ChIP-Seq_293T_Human1.91153636
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.90808739
34* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90527003
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90317657
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.87414037
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85142853
38* GATA2_21666600_ChIP-Seq_HMVEC_Human1.84914813
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84439157
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.79073901
41CJUN_26792858_Chip-Seq_BT549_Human1.76463629
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75947492
43SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.73256714
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72996615
45GATA6_25053715_ChIP-Seq_YYC3_Human1.70176135
46PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.67423486
47SOX2_20726797_ChIP-Seq_SW620_Human1.65909111
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62282094
49* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.61678606
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60586183
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60222795
52SPI1_23547873_ChIP-Seq_NB4_Human1.59698135
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.59207526
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59093072
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57768532
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57439425
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55607222
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53537465
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.53114110
60DCP1A_22483619_ChIP-Seq_HELA_Human1.51500351
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50295807
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.47897557
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.47897557
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44331699
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44255195
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42637540
67VDR_24787735_ChIP-Seq_THP-1_Human1.42065752
68BRD4_25478319_ChIP-Seq_HGPS_Human1.41602212
69* VDR_24763502_ChIP-Seq_THP-1_Human1.41432692
70* GATA3_24758297_ChIP-Seq_MCF-7_Human1.39948461
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39940642
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38156684
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37490400
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.36642319
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36064755
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.35242997
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34280394
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33939032
79* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33220102
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32172742
81MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31118159
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29860054
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28881280
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28638373
85PU_27001747_Chip-Seq_BMDM_Mouse1.28538854
86MYB_26560356_Chip-Seq_TH2_Human1.28315679
87* ELF5_23300383_ChIP-Seq_T47D_Human1.27633274
88E2F7_22180533_ChIP-Seq_HELA_Human1.25624533
89MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24869271
90FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24577818
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24237270
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23156203
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23068623
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.22978107
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.22629172
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22524056
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.22311524
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.21614525
99SPI1_23127762_ChIP-Seq_K562_Human1.21490960
100EOMES_21245162_ChIP-Seq_HESCs_Human1.18893450
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18857647
102TP63_23658742_ChIP-Seq_EP156T_Human1.15339530
103VDR_21846776_ChIP-Seq_THP-1_Human1.14320238
104P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13671903
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12417510
106* MAF_26560356_Chip-Seq_TH1_Human1.12178145
107UBF1/2_26484160_Chip-Seq_HMECs_Human1.10200989
108* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10134808
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.09502497
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.09455072
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.06421560
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05994170
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05918078
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05784661
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05650854
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05409453
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04731216
118* ATF3_27146783_Chip-Seq_COLON_Human1.03904443
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03818028
120* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03072780
121* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02438199
122MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01033118
123* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00357794
124* GATA4_25053715_ChIP-Seq_YYC3_Human1.00176199
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99718964
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99663363
127* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99603017
128CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99271005
129FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98977019
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98353859
131TFEB_21752829_ChIP-Seq_HELA_Human0.97765678
132NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97716154
133E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97234800
134ELK1_19687146_ChIP-ChIP_HELA_Human0.96548215
135MYB_26560356_Chip-Seq_TH1_Human0.96524705
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95793232
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.95510577
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94951035
139NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94532238
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93949234
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93833481
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93741750
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92686239
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92409673
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91119008
146PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89732421
147KLF5_25053715_ChIP-Seq_YYC3_Human0.89557155
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86759849
149GATA1_22025678_ChIP-Seq_K562_Human0.86484702
150RUNX_20019798_ChIP-Seq_JUKART_Human0.85800996
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85485534
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85272379
153* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84884108
154RACK7_27058665_Chip-Seq_MCF-7_Human0.83489863
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83050216
156TP53_18474530_ChIP-ChIP_U2OS_Human0.82382694
157AR_21909140_ChIP-Seq_LNCAP_Human0.81269303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development3.78419821
2MP0000579_abnormal_nail_morphology3.59000011
3MP0008438_abnormal_cutaneous_collagen3.49251855
4MP0004264_abnormal_extraembryonic_tissu3.26311363
5MP0010678_abnormal_skin_adnexa3.09367590
6MP0003806_abnormal_nucleotide_metabolis2.88468702
7MP0002796_impaired_skin_barrier2.79804515
8MP0003705_abnormal_hypodermis_morpholog2.76270027
9MP0003436_decreased_susceptibility_to2.76265752
10MP0001835_abnormal_antigen_presentation2.75486894
11MP0001958_emphysema2.59915575
12MP0003566_abnormal_cell_adhesion2.47661619
13MP0000537_abnormal_urethra_morphology2.45187721
14MP0002148_abnormal_hypersensitivity_rea2.41423408
15MP0009785_altered_susceptibility_to2.37925266
16MP0000383_abnormal_hair_follicle2.27697564
17MP0010352_gastrointestinal_tract_polyps2.20504248
18MP0004957_abnormal_blastocyst_morpholog2.18863006
19MP0001216_abnormal_epidermal_layer2.17323924
20MP0005501_abnormal_skin_physiology2.15758006
21MP0002419_abnormal_innate_immunity2.14024591
22MP0003279_aneurysm2.13387718
23MP0000762_abnormal_tongue_morphology2.11060787
24MP0005275_abnormal_skin_tensile2.09763152
25MP0003091_abnormal_cell_migration2.03798805
26MP0003303_peritoneal_inflammation2.00965585
27MP0002877_abnormal_melanocyte_morpholog1.98585124
28MP0000685_abnormal_immune_system1.97450748
29MP0002138_abnormal_hepatobiliary_system1.96741710
30MP0003724_increased_susceptibility_to1.94053947
31MP0002098_abnormal_vibrissa_morphology1.93978768
32MP0008260_abnormal_autophagy1.92696336
33MP0001533_abnormal_skeleton_physiology1.92296069
34MP0000467_abnormal_esophagus_morphology1.91465973
35MP0005058_abnormal_lysosome_morphology1.90084698
36MP0005023_abnormal_wound_healing1.84477153
37MP0000858_altered_metastatic_potential1.81977566
38MP0001879_abnormal_lymphatic_vessel1.78918218
39MP0004272_abnormal_basement_membrane1.78605130
40MP0005000_abnormal_immune_tolerance1.77238208
41MP0002166_altered_tumor_susceptibility1.70870576
42MP0001849_ear_inflammation1.68418131
43MP0000343_altered_response_to1.68175117
44MP0005025_abnormal_response_to1.67400326
45MP0006054_spinal_hemorrhage1.63596009
46MP0002006_tumorigenesis1.62554546
47MP0003300_gastrointestinal_ulcer1.61634451
48MP0001790_abnormal_immune_system1.58933623
49MP0005387_immune_system_phenotype1.58933623
50MP0009780_abnormal_chondrocyte_physiolo1.58618165
51MP0003693_abnormal_embryo_hatching1.58100015
52MP0010771_integument_phenotype1.57430596
53MP0003448_altered_tumor_morphology1.57209276
54MP0002452_abnormal_antigen_presenting1.57110012
55MP0005623_abnormal_meninges_morphology1.55946994
56MP0001853_heart_inflammation1.55055504
57MP0009053_abnormal_anal_canal1.50854189
58MP0000377_abnormal_hair_follicle1.49828027
59MP0010368_abnormal_lymphatic_system1.49007136
60MP0005164_abnormal_response_to1.47058850
61MP0009697_abnormal_copulation1.45249602
62MP0005076_abnormal_cell_differentiation1.42581765
63MP0002405_respiratory_system_inflammati1.39670942
64MP0003786_premature_aging1.38940398
65MP0006082_CNS_inflammation1.36736884
66MP0005397_hematopoietic_system_phenotyp1.36283311
67MP0001545_abnormal_hematopoietic_system1.36283311
68MP0004947_skin_inflammation1.34685178
69MP0005464_abnormal_platelet_physiology1.33669659
70MP0002295_abnormal_pulmonary_circulatio1.32587987
71MP0009278_abnormal_bone_marrow1.32401882
72MP0001348_abnormal_lacrimal_gland1.32094063
73MP0000767_abnormal_smooth_muscle1.31412877
74MP0002723_abnormal_immune_serum1.31011038
75MP0001819_abnormal_immune_cell1.30957461
76MP0004782_abnormal_surfactant_physiolog1.30267752
77MP0002420_abnormal_adaptive_immunity1.28109375
78MP0003828_pulmonary_edema1.27508954
79MP0002998_abnormal_bone_remodeling1.26844353
80MP0003191_abnormal_cellular_cholesterol1.26493959
81MP0005503_abnormal_tendon_morphology1.22826404
82MP0005167_abnormal_blood-brain_barrier1.22369681
83MP0001542_abnormal_bone_strength1.22151739
84MP0005390_skeleton_phenotype1.21984955
85MP0010155_abnormal_intestine_physiology1.21212967
86MP0005083_abnormal_biliary_tract1.21192021
87MP0000249_abnormal_blood_vessel1.20572711
88MP0009384_cardiac_valve_regurgitation1.19355275
89MP0004883_abnormal_blood_vessel1.18848932
90MP0000647_abnormal_sebaceous_gland1.18814014
91MP0001845_abnormal_inflammatory_respons1.17246121
92MP0009764_decreased_sensitivity_to1.16883513
93MP0008004_abnormal_stomach_pH1.16487524
94MP0001800_abnormal_humoral_immune1.15059224
95MP0004510_myositis1.14624137
96MP0010307_abnormal_tumor_latency1.14142635
97MP0003453_abnormal_keratinocyte_physiol1.13720044
98MP0000569_abnormal_digit_pigmentation1.11537757
99MP0005671_abnormal_response_to1.10549485
100MP0003075_altered_response_to1.10545243
101MP0003718_maternal_effect1.10105898
102MP0002254_reproductive_system_inflammat1.08395766
103MP0002086_abnormal_extraembryonic_tissu1.07618255
104MP0003950_abnormal_plasma_membrane1.06592970
105MP0002060_abnormal_skin_morphology1.06392170
106MP0000733_abnormal_muscle_development1.05067463
107MP0004808_abnormal_hematopoietic_stem1.04845237
108MP0002933_joint_inflammation1.03714089
109MP0001346_abnormal_lacrimal_gland0.99488887
110MP0000465_gastrointestinal_hemorrhage0.99180728
111MP0003172_abnormal_lysosome_physiology0.98058731
112MP0000566_synostosis0.97268114
113MP0003077_abnormal_cell_cycle0.96789270
114MP0003315_abnormal_perineum_morphology0.96399867
115MP0000516_abnormal_urinary_system0.95100697
116MP0005367_renal/urinary_system_phenotyp0.95100697
117MP0009931_abnormal_skin_appearance0.94454508
118MP0009333_abnormal_splenocyte_physiolog0.94226546
119MP0001915_intracranial_hemorrhage0.93895349
120MP0000427_abnormal_hair_cycle0.93475927
121MP0001697_abnormal_embryo_size0.93326895
122MP0000627_abnormal_mammary_gland0.93208726
123MP0001851_eye_inflammation0.93151604
124MP0008932_abnormal_embryonic_tissue0.93086607
125MP0002234_abnormal_pharynx_morphology0.92765373
126MP0001730_embryonic_growth_arrest0.92129045
127MP0005257_abnormal_intraocular_pressure0.91825160
128MP0010234_abnormal_vibrissa_follicle0.91452136
129MP0005330_cardiomyopathy0.90799546
130MP0004019_abnormal_vitamin_homeostasis0.90696203
131MP0004185_abnormal_adipocyte_glucose0.88657134
132MP0003045_fibrosis0.88442779
133MP0008469_abnormal_protein_level0.87441573
134MP0000490_abnormal_crypts_of0.86935058
135MP0002396_abnormal_hematopoietic_system0.86570935
136MP0000716_abnormal_immune_system0.85217811
137MP0001243_abnormal_dermal_layer0.85089993
138MP0001881_abnormal_mammary_gland0.83207687
139MP0003795_abnormal_bone_structure0.82517935
140MP0005248_abnormal_Harderian_gland0.82362129
141MP0002168_other_aberrant_phenotype0.82023567
142MP0005165_increased_susceptibility_to0.81454468
143MP0003984_embryonic_growth_retardation0.81132551
144MP0003186_abnormal_redox_activity0.81073709
145MP0008007_abnormal_cellular_replicative0.80408044
146MP0000358_abnormal_cell_content/0.79798946
147MP0006138_congestive_heart_failure0.79249731
148MP0001672_abnormal_embryogenesis/_devel0.78041836
149MP0005380_embryogenesis_phenotype0.78041836
150MP0002088_abnormal_embryonic_growth/wei0.76610413
151MP0005166_decreased_susceptibility_to0.75278752
152MP0010030_abnormal_orbit_morphology0.74431353
153MP0002080_prenatal_lethality0.73212167
154MP0001191_abnormal_skin_condition0.73170194
155MP0002697_abnormal_eye_size0.73062255
156MP0005409_darkened_coat_color0.71940057
157MP0002332_abnormal_exercise_endurance0.69649305
158MP0002084_abnormal_developmental_patter0.68872455
159MP0000350_abnormal_cell_proliferation0.65689009
160MP0000367_abnormal_coat/_hair0.65578353
161MP0003111_abnormal_nucleus_morphology0.64136444
162MP0008058_abnormal_DNA_repair0.63559438
163MP0003119_abnormal_digestive_system0.63353752
164MP0005621_abnormal_cell_physiology0.63288189
165MP0005360_urolithiasis0.62891946
166MP0004381_abnormal_hair_follicle0.62010041
167MP0004484_altered_response_of0.60975765
168MP0001661_extended_life_span0.59786134
169MP0004197_abnormal_fetal_growth/weight/0.59128285
170MP0005395_other_phenotype0.59121416

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.11268178
2Onycholysis (HP:0001806)7.01130317
3Milia (HP:0001056)6.19447236
4Fragile nails (HP:0001808)6.07578027
5Plantar hyperkeratosis (HP:0007556)5.67118266
6Recurrent abscess formation (HP:0002722)4.43518615
7Eczematoid dermatitis (HP:0000976)4.33346872
8Palmoplantar hyperkeratosis (HP:0000972)4.14561203
9Pili torti (HP:0003777)4.12912480
10Premature rupture of membranes (HP:0001788)4.10424362
11Nail dystrophy (HP:0008404)4.02608533
12Recurrent bacterial skin infections (HP:0005406)3.99674492
13Palmar hyperkeratosis (HP:0010765)3.97203617
14Abnormality of nail color (HP:0100643)3.83610803
15Osteolytic defects of the phalanges of the hand (HP:0009771)3.82700086
16Osteolytic defects of the hand bones (HP:0009699)3.82700086
17Alopecia of scalp (HP:0002293)3.71457910
18Interstitial pulmonary disease (HP:0006530)3.64502174
19Protrusio acetabuli (HP:0003179)3.61008551
20Sparse eyelashes (HP:0000653)3.50183242
21Peritonitis (HP:0002586)3.47358265
22Ventricular tachycardia (HP:0004756)3.40899995
23Palpitations (HP:0001962)3.36483595
24Abnormal hair laboratory examination (HP:0003328)3.35911317
25Aortic aneurysm (HP:0004942)3.29764387
26Cervical subluxation (HP:0003308)3.25680504
27Ridged nail (HP:0001807)3.25059906
28Cerebral aneurysm (HP:0004944)3.23528346
29Vertebral compression fractures (HP:0002953)3.21100503
30Aplasia cutis congenita (HP:0001057)3.19529856
31Myositis (HP:0100614)3.15183522
32Hematochezia (HP:0002573)3.13808319
33Atrophic scars (HP:0001075)3.09085701
34Selective tooth agenesis (HP:0001592)3.08623126
35Abnormal blistering of the skin (HP:0008066)3.07661712
36Orchitis (HP:0100796)3.01806975
37Hypoplasia of dental enamel (HP:0006297)3.00869418
38Recurrent gram-negative bacterial infections (HP:0005420)2.99588547
39Abnormality of macrophages (HP:0004311)2.96871905
40Aortic dissection (HP:0002647)2.89042888
41Vascular tortuosity (HP:0004948)2.88638542
42Ankyloglossia (HP:0010296)2.86460556
43Woolly hair (HP:0002224)2.83610553
44Lip pit (HP:0100267)2.81903488
45Reduced subcutaneous adipose tissue (HP:0003758)2.81190336
46Autoimmune thrombocytopenia (HP:0001973)2.79208463
47Abnormality of placental membranes (HP:0011409)2.77343324
48Amniotic constriction ring (HP:0009775)2.77343324
49Elevated erythrocyte sedimentation rate (HP:0003565)2.68901078
50Stenosis of the external auditory canal (HP:0000402)2.68350141
51Arterial tortuosity (HP:0005116)2.66088705
52Pustule (HP:0200039)2.65618226
53Pterygium (HP:0001059)2.65222708
54Vacuolated lymphocytes (HP:0001922)2.62957410
55Dilatation of the ascending aorta (HP:0005111)2.62278847
56Absent eyelashes (HP:0000561)2.54090651
57Retrobulbar optic neuritis (HP:0100654)2.52049892
58Optic neuritis (HP:0100653)2.52049892
59Vascular calcification (HP:0004934)2.51228390
60Short nail (HP:0001799)2.51179813
61Posterior subcapsular cataract (HP:0007787)2.45686500
62Dry hair (HP:0011359)2.44969924
63Congenital ichthyosiform erythroderma (HP:0007431)2.43946013
64Abnormality of oral frenula (HP:0000190)2.42850624
65Trismus (HP:0000211)2.41003114
66Mediastinal lymphadenopathy (HP:0100721)2.40405539
67Systemic lupus erythematosus (HP:0002725)2.39419191
68Thrombocytosis (HP:0001894)2.37099819
69Amelogenesis imperfecta (HP:0000705)2.36867469
70Myocardial infarction (HP:0001658)2.36518218
71Gingivitis (HP:0000230)2.35332276
72Hypotrichosis (HP:0001006)2.34505724
73Oral leukoplakia (HP:0002745)2.32470077
74Death in infancy (HP:0001522)2.32103305
75Increased cerebral lipofuscin (HP:0011813)2.31210109
76Malnutrition (HP:0004395)2.31018732
77Abnormal auditory evoked potentials (HP:0006958)2.29638919
78Periodontitis (HP:0000704)2.28453296
79Micronodular cirrhosis (HP:0001413)2.27687997
80Natal tooth (HP:0000695)2.26643000
81Curly hair (HP:0002212)2.25952560
82Thick nail (HP:0001805)2.25586841
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.24903169
84Vertebral hypoplasia (HP:0008417)2.23690792
85Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.23690792
86Esophageal varix (HP:0002040)2.23466471
87Wormian bones (HP:0002645)2.21920532
88Soft skin (HP:0000977)2.21476349
89Muscle fibrillation (HP:0010546)2.21387208
90Shallow orbits (HP:0000586)2.19583247
91Axonal loss (HP:0003447)2.15360430
92Poikiloderma (HP:0001029)2.13434779
93Tetraparesis (HP:0002273)2.13313584
94Nephritis (HP:0000123)2.12853301
95Popliteal pterygium (HP:0009756)2.12638611
96Subacute progressive viral hepatitis (HP:0006572)2.11203125
97Proximal tubulopathy (HP:0000114)2.10219527
98Spondylolisthesis (HP:0003302)2.09743356
99Arterial thrombosis (HP:0004420)2.09625607
100Pulmonary infiltrates (HP:0002113)2.09087924
101Fused cervical vertebrae (HP:0002949)2.08980922
102Absent eyebrow (HP:0002223)2.08212568
103Recurrent skin infections (HP:0001581)2.07749621
104Hypoplasia of the uterus (HP:0000013)2.07259847
105Broad face (HP:0000283)2.06528027
106Abnormality of the pericardium (HP:0001697)2.05098363
107Recurrent fungal infections (HP:0002841)2.03992300
108Cardiovascular calcification (HP:0011915)2.03746369
109Beaking of vertebral bodies (HP:0004568)2.03469664
110Spinal cord lesions (HP:0100561)2.02779274
111Syringomyelia (HP:0003396)2.02779274
112Palmoplantar keratoderma (HP:0000982)2.02615116
113Osteomyelitis (HP:0002754)2.01910013
114Dysostosis multiplex (HP:0000943)2.01175259
115Fragile skin (HP:0001030)2.00018505
116Increased density of long bones (HP:0006392)1.99940888
117Ankle contracture (HP:0006466)1.99372402
118Increased connective tissue (HP:0009025)1.99283333
119Distal lower limb muscle weakness (HP:0009053)1.99064922
120Basal ganglia calcification (HP:0002135)1.98215405
121Carious teeth (HP:0000670)1.97655918
122Urinary glycosaminoglycan excretion (HP:0003541)1.97403110
123Mucopolysacchariduria (HP:0008155)1.97403110
124Absent frontal sinuses (HP:0002688)1.96696968
125Glomerulonephritis (HP:0000099)1.96617925
126Spontaneous hematomas (HP:0007420)1.94613252
127Cellulitis (HP:0100658)1.93764114
128Abnormalities of placenta or umbilical cord (HP:0001194)1.93229202
129Abnormality of the distal phalanges of the toes (HP:0010182)1.93007983
130Bifid uvula (HP:0000193)1.92697615
131Obstructive lung disease (HP:0006536)1.92324353
132Chronic obstructive pulmonary disease (HP:0006510)1.92324353
133Hypoplastic labia majora (HP:0000059)1.91651889
134Radial bowing (HP:0002986)1.91103690
135Joint stiffness (HP:0001387)1.89925087
136Eosinophilia (HP:0001880)1.87931804
137Prostate neoplasm (HP:0100787)1.87672665
138Advanced eruption of teeth (HP:0006288)1.85407482
139Sparse scalp hair (HP:0002209)1.85332673
140Vasculitis (HP:0002633)1.84356343
141Cheilitis (HP:0100825)1.83320211
142Frequent falls (HP:0002359)1.81413171
143Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81088397
144Persistence of primary teeth (HP:0006335)1.80688567
145Blue sclerae (HP:0000592)1.79763240
146Abnormality of alanine metabolism (HP:0010916)1.79603016
147Hyperalaninemia (HP:0003348)1.79603016
148Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79603016
149Aneurysm (HP:0002617)1.79526447
150Subcapsular cataract (HP:0000523)1.77956076
151Pathologic fracture (HP:0002756)1.77674842
152Increased mean platelet volume (HP:0011877)1.77490995
153Conjugated hyperbilirubinemia (HP:0002908)1.77214611
154Bilateral sensorineural hearing impairment (HP:0008619)1.76608430
155Hepatocellular carcinoma (HP:0001402)1.76364125
156Deviation of the thumb (HP:0009603)1.76337095
157Abnormality of methionine metabolism (HP:0010901)1.76269842
158Tongue fasciculations (HP:0001308)1.76020590
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75882461
160Abnormality of polysaccharide metabolism (HP:0011012)1.75882461
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75882461
162Disinhibition (HP:0000734)1.75439079
163Coxa vara (HP:0002812)1.74663403
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.74338944
165Spinal rigidity (HP:0003306)1.74226068
166Skin ulcer (HP:0200042)1.74177449
167Ureteral duplication (HP:0000073)1.74148994
168Ectropion (HP:0000656)1.73783893
169Distal upper limb amyotrophy (HP:0007149)1.73354871
170Upper limb amyotrophy (HP:0009129)1.73354871
171Abnormal platelet volume (HP:0011876)1.72939964
172Hand muscle atrophy (HP:0009130)1.72553263
173Camptodactyly of toe (HP:0001836)1.71439479
174Intrahepatic cholestasis (HP:0001406)1.70774444
175Nausea (HP:0002018)1.70710843
176Glucose intolerance (HP:0000833)1.69632421
177Erythema (HP:0010783)1.69271227
178Abnormality of the preputium (HP:0100587)1.69100965
179Anonychia (HP:0001798)1.66854326
180Wide intermamillary distance (HP:0006610)1.66664811
181Abnormality of the gastric mucosa (HP:0004295)1.66486247
182Abnormality of the labia majora (HP:0012881)1.64705710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.61199499
2TESK13.35779885
3MAP3K143.12005976
4TTN2.73784850
5PIM22.59744643
6NEK92.33346437
7STK392.32127479
8EIF2AK12.20282274
9TRPM72.17002434
10TRIM282.15198922
11SIK32.14008852
12TGFBR22.12228755
13TBK12.09012279
14PAK42.06694388
15LIMK12.06625756
16MST41.93265393
17BLK1.90581186
18ERBB31.89791779
19TYK21.76105037
20LRRK21.75632799
21IKBKB1.75406327
22RPS6KA41.74178495
23STK101.73569511
24NME11.71797610
25BUB11.71582606
26IRAK41.67122350
27EPHB11.65976197
28JAK31.65445567
29MAP3K31.65355254
30RIPK41.63951218
31TRIB31.61075334
32ERN11.57016015
33MST1R1.56899393
34LMTK21.55324783
35OXSR11.52086230
36PTK61.48292747
37STK38L1.41279607
38MAP2K31.38012469
39BMX1.37740574
40NME21.31101955
41CHUK1.25071218
42KDR1.23351381
43JAK11.21974328
44TSSK61.21834506
45PDK21.21581406
46STK31.18504579
47IRAK31.16658685
48FRK1.11645000
49PTK21.11223925
50TESK21.10955075
51TGFBR11.09584167
52IKBKE1.08991387
53NEK11.08759720
54DDR21.07915088
55PBK1.07145825
56MOS1.04984464
57CSK1.04940091
58KIT1.00301967
59LATS21.00187323
60EPHB20.99485213
61ZAP700.96023277
62CDK60.95449999
63PKN20.95232306
64MAP3K20.93083592
65RIPK10.91877057
66FER0.91549703
67PAK20.91547203
68SRPK10.89872076
69PTK2B0.89545181
70ABL20.88795898
71PIM10.85350528
72STK160.84660261
73EIF2AK30.84586119
74ERBB40.83830300
75MYLK0.82467237
76MAP3K80.82446559
77TEC0.80976861
78NUAK10.80281951
79MAP3K130.79777238
80VRK20.79494141
81LATS10.78668333
82PIK3CG0.78592153
83PLK40.77775832
84MAP3K110.77695020
85MAP3K90.77523579
86SCYL20.74996041
87HCK0.74753313
88PRKCI0.74176703
89TNIK0.73138573
90FGR0.72804098
91MET0.71553617
92MAPKAPK20.71318590
93PDGFRA0.69499395
94RPS6KB20.69215527
95ABL10.69137602
96BRSK20.68127808
97DAPK10.67860169
98EIF2AK20.66368589
99ILK0.66227960
100WEE10.64552272
101FLT30.63865120
102EGFR0.63269766
103CSF1R0.63119848
104BTK0.62034864
105ZAK0.60909126
106MAPKAPK30.59329632
107PLK30.57589163
108PDGFRB0.56041470
109PRKG20.55620026
110TTK0.54938346
111STK40.54512300
112MAP2K10.54331473
113PIK3CA0.54186992
114MAP3K60.53874565
115MAP3K120.50025971
116PAK10.49727244
117STK240.48830930
118CDK80.48769766
119CAMKK20.48663172
120ROCK20.48047432
121BMPR1B0.47918272
122FGFR10.47359826
123DAPK30.46881345
124PAK30.46446045
125TIE10.46434781
126ACVR1B0.46170050
127MAP2K20.45300896
128PRKCD0.44319758
129TAOK30.43099696
130KSR10.42658569
131MELK0.42370830
132MATK0.41425421
133STK380.39985628
134MAP3K50.39143538
135BCR0.39055519
136ARAF0.38373809
137EPHA30.38101859
138AURKB0.37588424
139AKT20.35082131
140ROCK10.31926231
141PLK10.31334129
142ADRBK10.30073083
143SMG10.29596176
144PRKCE0.29216940
145MKNK10.28565206
146SIK10.27789169
147DMPK0.26339472
148MAP2K60.26263196
149CDK90.20745140
150BRAF0.19838302

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68049994
2Leishmaniasis_Homo sapiens_hsa051402.62311941
3Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.20483220
4Galactose metabolism_Homo sapiens_hsa000522.16608502
5Malaria_Homo sapiens_hsa051442.15435883
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.12450250
7Pertussis_Homo sapiens_hsa051332.08510972
8Shigellosis_Homo sapiens_hsa051312.03918202
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98160907
10TNF signaling pathway_Homo sapiens_hsa046681.95140162
11Legionellosis_Homo sapiens_hsa051341.95032749
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92501179
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.85807385
14Toxoplasmosis_Homo sapiens_hsa051451.85688665
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.85510699
16Small cell lung cancer_Homo sapiens_hsa052221.83248468
17Apoptosis_Homo sapiens_hsa042101.82781923
18Osteoclast differentiation_Homo sapiens_hsa043801.81201397
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80984497
20Viral myocarditis_Homo sapiens_hsa054161.79892064
21Salmonella infection_Homo sapiens_hsa051321.77240112
22Phagosome_Homo sapiens_hsa041451.73334525
23ECM-receptor interaction_Homo sapiens_hsa045121.72215083
24Folate biosynthesis_Homo sapiens_hsa007901.70195508
25Mismatch repair_Homo sapiens_hsa034301.70153989
26Graft-versus-host disease_Homo sapiens_hsa053321.66899591
27Allograft rejection_Homo sapiens_hsa053301.64698193
28Lysosome_Homo sapiens_hsa041421.62648776
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62409487
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.61598542
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61486165
32Nucleotide excision repair_Homo sapiens_hsa034201.60750506
33Sulfur metabolism_Homo sapiens_hsa009201.60632720
34Tuberculosis_Homo sapiens_hsa051521.59903519
35Focal adhesion_Homo sapiens_hsa045101.56534521
36Rheumatoid arthritis_Homo sapiens_hsa053231.55131991
37Measles_Homo sapiens_hsa051621.53961577
38Adherens junction_Homo sapiens_hsa045201.51351473
39Staphylococcus aureus infection_Homo sapiens_hsa051501.50990017
40Amoebiasis_Homo sapiens_hsa051461.50385383
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.48149493
42Proteoglycans in cancer_Homo sapiens_hsa052051.44001102
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41528938
44Influenza A_Homo sapiens_hsa051641.37000983
45Protein export_Homo sapiens_hsa030601.36982301
46Non-homologous end-joining_Homo sapiens_hsa034501.36590386
47Pyrimidine metabolism_Homo sapiens_hsa002401.35090735
48p53 signaling pathway_Homo sapiens_hsa041151.33873329
49RNA transport_Homo sapiens_hsa030131.32586232
50Other glycan degradation_Homo sapiens_hsa005111.32353688
51Pentose phosphate pathway_Homo sapiens_hsa000301.32172904
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28679212
53Hematopoietic cell lineage_Homo sapiens_hsa046401.28030152
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26993965
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26575881
56Steroid biosynthesis_Homo sapiens_hsa001001.24654199
57Chronic myeloid leukemia_Homo sapiens_hsa052201.24533145
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.23853235
59DNA replication_Homo sapiens_hsa030301.20779058
60Antigen processing and presentation_Homo sapiens_hsa046121.20103280
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15520695
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11066138
63Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10728183
64Hepatitis B_Homo sapiens_hsa051611.09297118
65Sphingolipid metabolism_Homo sapiens_hsa006001.09168564
66Pancreatic cancer_Homo sapiens_hsa052121.08801716
67Bladder cancer_Homo sapiens_hsa052191.08475811
68Ribosome_Homo sapiens_hsa030101.07968965
69Chemokine signaling pathway_Homo sapiens_hsa040621.04595503
70Jak-STAT signaling pathway_Homo sapiens_hsa046301.00696655
71Pyruvate metabolism_Homo sapiens_hsa006200.99221771
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98875073
73Autoimmune thyroid disease_Homo sapiens_hsa053200.98447830
74Renal cell carcinoma_Homo sapiens_hsa052110.98424034
75Platelet activation_Homo sapiens_hsa046110.97698635
76Cell cycle_Homo sapiens_hsa041100.97475911
77Herpes simplex infection_Homo sapiens_hsa051680.97427556
78Basal transcription factors_Homo sapiens_hsa030220.96672968
79MicroRNAs in cancer_Homo sapiens_hsa052060.95217028
80One carbon pool by folate_Homo sapiens_hsa006700.92992854
81Fatty acid elongation_Homo sapiens_hsa000620.92836537
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91394932
83Carbon metabolism_Homo sapiens_hsa012000.90754250
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90458528
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86955358
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86375585
87Viral carcinogenesis_Homo sapiens_hsa052030.85145529
88Homologous recombination_Homo sapiens_hsa034400.84407740
89RNA polymerase_Homo sapiens_hsa030200.84312572
90N-Glycan biosynthesis_Homo sapiens_hsa005100.83181727
91B cell receptor signaling pathway_Homo sapiens_hsa046620.82734139
92Vitamin B6 metabolism_Homo sapiens_hsa007500.82064610
93Asthma_Homo sapiens_hsa053100.81812644
94Hepatitis C_Homo sapiens_hsa051600.80906857
95HIF-1 signaling pathway_Homo sapiens_hsa040660.79726279
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79527974
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75882785
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75642554
99TGF-beta signaling pathway_Homo sapiens_hsa043500.75526617
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.74263489
101HTLV-I infection_Homo sapiens_hsa051660.72859802
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72732650
103Biosynthesis of amino acids_Homo sapiens_hsa012300.71357216
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70652245
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70455026
106Type I diabetes mellitus_Homo sapiens_hsa049400.69690254
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.69402064
108Acute myeloid leukemia_Homo sapiens_hsa052210.69173573
109African trypanosomiasis_Homo sapiens_hsa051430.69057412
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67672541
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.67313232
112Epstein-Barr virus infection_Homo sapiens_hsa051690.67129093
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66737692
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66000642
115Spliceosome_Homo sapiens_hsa030400.65809869
116Dilated cardiomyopathy_Homo sapiens_hsa054140.64648247
117Oxidative phosphorylation_Homo sapiens_hsa001900.64602164
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64354964
119Fructose and mannose metabolism_Homo sapiens_hsa000510.64058265
120Melanoma_Homo sapiens_hsa052180.61523248
121Endocytosis_Homo sapiens_hsa041440.61400899
122Pathways in cancer_Homo sapiens_hsa052000.60853405
123Renin-angiotensin system_Homo sapiens_hsa046140.59986945
124Proteasome_Homo sapiens_hsa030500.58916434
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58087707
126Tight junction_Homo sapiens_hsa045300.57682305
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.56737927
128VEGF signaling pathway_Homo sapiens_hsa043700.55357062
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55287680
130Starch and sucrose metabolism_Homo sapiens_hsa005000.52910952
131Prostate cancer_Homo sapiens_hsa052150.52277479
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52223466
133Rap1 signaling pathway_Homo sapiens_hsa040150.51292166
134Hippo signaling pathway_Homo sapiens_hsa043900.50930931
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49907576
136RNA degradation_Homo sapiens_hsa030180.47972688
137Huntingtons disease_Homo sapiens_hsa050160.47802369
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47220227
139Mineral absorption_Homo sapiens_hsa049780.47204022
140Endometrial cancer_Homo sapiens_hsa052130.46912480
141Parkinsons disease_Homo sapiens_hsa050120.46285365
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46226289
143Purine metabolism_Homo sapiens_hsa002300.46083635
144Vibrio cholerae infection_Homo sapiens_hsa051100.46078275
145Glutathione metabolism_Homo sapiens_hsa004800.42749026
146Wnt signaling pathway_Homo sapiens_hsa043100.42444710
147Base excision repair_Homo sapiens_hsa034100.42435627
148Phenylalanine metabolism_Homo sapiens_hsa003600.42169331
149Basal cell carcinoma_Homo sapiens_hsa052170.41110774
150Metabolic pathways_Homo sapiens_hsa011000.40953686
151Thyroid cancer_Homo sapiens_hsa052160.40689571
152Hedgehog signaling pathway_Homo sapiens_hsa043400.40327887
153Alzheimers disease_Homo sapiens_hsa050100.40064320
154Complement and coagulation cascades_Homo sapiens_hsa046100.39885968
155Prolactin signaling pathway_Homo sapiens_hsa049170.39822064
156Collecting duct acid secretion_Homo sapiens_hsa049660.39696892
157Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39695543
158Systemic lupus erythematosus_Homo sapiens_hsa053220.37698243
159Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36669644
160Selenocompound metabolism_Homo sapiens_hsa004500.36585863
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36517456
162Propanoate metabolism_Homo sapiens_hsa006400.36386859
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33193799

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