ANXA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.84833130
2neutrophil activation involved in immune response (GO:0002283)5.49511130
3positive regulation of interferon-alpha production (GO:0032727)4.52065286
4regulation of interferon-alpha production (GO:0032647)4.22905269
5production of molecular mediator involved in inflammatory response (GO:0002532)4.07043110
6positive regulation by symbiont of host defense response (GO:0052509)4.02490567
7modulation by symbiont of host defense response (GO:0052031)4.02490567
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02490567
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02490567
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.02490567
11modulation by symbiont of host immune response (GO:0052553)4.02490567
12response to peptidoglycan (GO:0032494)3.90030516
13hydrogen peroxide biosynthetic process (GO:0050665)3.89813775
14granulocyte activation (GO:0036230)3.87610775
15peptide catabolic process (GO:0043171)3.85832207
16immunoglobulin mediated immune response (GO:0016064)3.83774628
17intestinal absorption (GO:0050892)3.83070311
18neutrophil activation (GO:0042119)3.83064881
19negative regulation of complement activation (GO:0045916)3.82457045
20cellular glucuronidation (GO:0052695)3.79575556
21transepithelial transport (GO:0070633)3.75915238
22negative regulation of protein activation cascade (GO:2000258)3.75863459
23uronic acid metabolic process (GO:0006063)3.72420997
24glucuronate metabolic process (GO:0019585)3.72420997
25calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.71951942
26regulation of interferon-beta biosynthetic process (GO:0045357)3.64566347
27regulation of complement activation (GO:0030449)3.60959377
28positive regulation of natural killer cell differentiation (GO:0032825)3.60335262
29regulation of apoptotic process involved in morphogenesis (GO:1902337)3.58562303
30regulation of protein activation cascade (GO:2000257)3.53721380
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.52339042
32L-phenylalanine metabolic process (GO:0006558)3.52339042
33type I interferon signaling pathway (GO:0060337)3.49522800
34cellular response to type I interferon (GO:0071357)3.49522800
35response to type I interferon (GO:0034340)3.49136250
36ethanol oxidation (GO:0006069)3.47891703
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.45175550
38primary alcohol catabolic process (GO:0034310)3.44607567
39polyketide metabolic process (GO:0030638)3.44157747
40doxorubicin metabolic process (GO:0044598)3.44157747
41daunorubicin metabolic process (GO:0044597)3.44157747
42antigen processing and presentation of endogenous antigen (GO:0019883)3.43401363
43epoxygenase P450 pathway (GO:0019373)3.41380105
44T-helper 1 type immune response (GO:0042088)3.39042300
45natural killer cell mediated cytotoxicity (GO:0042267)3.36790231
46natural killer cell mediated immunity (GO:0002228)3.36790231
47reactive oxygen species biosynthetic process (GO:1903409)3.35798150
48respiratory burst (GO:0045730)3.35088922
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.34768073
50eosinophil chemotaxis (GO:0048245)3.33830228
51negative regulation of humoral immune response (GO:0002921)3.30920364
52positive regulation of interferon-beta production (GO:0032728)3.28312162
53regulation of metalloenzyme activity (GO:0048552)3.26784377
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23703373
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23703373
56macrophage activation involved in immune response (GO:0002281)3.21225597
57positive regulation of cellular amide metabolic process (GO:0034250)3.18738558
58ethanol metabolic process (GO:0006067)3.18541490
59positive regulation of antigen processing and presentation (GO:0002579)3.17754599
60regulation of bile acid biosynthetic process (GO:0070857)3.17283203
61response to interferon-alpha (GO:0035455)3.16091497
62regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.15997169
63positive regulation of monocyte chemotaxis (GO:0090026)3.14256968
64cellular response to interferon-alpha (GO:0035457)3.13441383
65complement activation, classical pathway (GO:0006958)3.12503469
66superoxide anion generation (GO:0042554)3.10515015
67regulation of T-helper 1 cell differentiation (GO:0045625)3.09596065
68aminoglycoside antibiotic metabolic process (GO:0030647)3.08481930
69positive regulation of chemokine biosynthetic process (GO:0045080)3.08380544
70flavonoid metabolic process (GO:0009812)3.08259144
71regulation of mononuclear cell migration (GO:0071675)3.08104506
72regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06362550
73diterpenoid biosynthetic process (GO:0016102)3.04978974
74intestinal cholesterol absorption (GO:0030299)3.04779214
75positive regulation of interleukin-12 production (GO:0032735)3.03580202
76myeloid dendritic cell differentiation (GO:0043011)3.02516976
77L-phenylalanine catabolic process (GO:0006559)2.97850656
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97850656
79negative regulation of viral genome replication (GO:0045071)2.97649632
80maintenance of gastrointestinal epithelium (GO:0030277)2.95444145
81regulation of activation of Janus kinase activity (GO:0010533)2.94838876
82eosinophil migration (GO:0072677)2.94778038
83xenobiotic catabolic process (GO:0042178)2.94607047
84desmosome organization (GO:0002934)2.93892454
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.93353232
86response to muramyl dipeptide (GO:0032495)2.92317466
87interferon-gamma-mediated signaling pathway (GO:0060333)2.90863693
88B cell mediated immunity (GO:0019724)2.90638955
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89826196
90regulation of RIG-I signaling pathway (GO:0039535)2.89395505
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88186919
92response to host immune response (GO:0052572)2.88186919
93acute-phase response (GO:0006953)2.88127260
94regulation of cholesterol homeostasis (GO:2000188)2.87857629
95transcytosis (GO:0045056)2.87411151
96response to interferon-beta (GO:0035456)2.87399568
97cellular response to interferon-beta (GO:0035458)2.87386491
98myeloid dendritic cell activation (GO:0001773)2.87328304
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85312339
100drug catabolic process (GO:0042737)2.84425133
101cellular response to exogenous dsRNA (GO:0071360)2.84202300
102monocyte chemotaxis (GO:0002548)2.83583835
103positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82221055
104positive regulation of type 2 immune response (GO:0002830)2.81128198
105primary alcohol metabolic process (GO:0034308)2.80450694
106bile acid metabolic process (GO:0008206)2.76987294
107detection of molecule of bacterial origin (GO:0032490)2.76472157
108cellular response to zinc ion (GO:0071294)2.75418391
109signal peptide processing (GO:0006465)2.74650930
110acute inflammatory response (GO:0002526)2.73877348
111regulation of cholesterol storage (GO:0010885)2.73330324
112myeloid cell activation involved in immune response (GO:0002275)2.72647299
113positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72630422
114positive regulation of extracellular matrix organization (GO:1903055)2.72427703
115regulation of antigen processing and presentation (GO:0002577)2.72318954
116complement activation (GO:0006956)2.71143139
117retinal metabolic process (GO:0042574)2.69618651
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.69320459
119hepatocyte apoptotic process (GO:0097284)2.69054018
120angiotensin maturation (GO:0002003)2.68775172
121drug transmembrane transport (GO:0006855)2.67424833
122regulation of cholesterol esterification (GO:0010872)2.66985474
123complement activation, alternative pathway (GO:0006957)2.65837563
124regulation of chemokine biosynthetic process (GO:0045073)2.65632800
125regulation of vitamin metabolic process (GO:0030656)2.64660154
126positive regulation of heat generation (GO:0031652)2.64021047
127glycoside metabolic process (GO:0016137)2.63939851
128sequestering of metal ion (GO:0051238)2.63573769
129dendritic cell differentiation (GO:0097028)2.62651274
130regulation of transforming growth factor beta1 production (GO:0032908)2.62647906
131drug metabolic process (GO:0017144)2.62211656
132positive regulation of T cell migration (GO:2000406)2.62010319
133negative regulation of lipid storage (GO:0010888)2.61857115
134wound healing, spreading of epidermal cells (GO:0035313)2.61026502
135leukocyte mediated cytotoxicity (GO:0001909)2.60804509
136positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.60387905
137defense response to protozoan (GO:0042832)2.59462993
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.58955835
139negative regulation of blood coagulation (GO:0030195)2.58712147
140negative regulation of hemostasis (GO:1900047)2.58712147
141COPI coating of Golgi vesicle (GO:0048205)2.56495895
142Golgi transport vesicle coating (GO:0048200)2.56495895
143negative regulation of interleukin-17 production (GO:0032700)2.56244555
144regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.55957501
145oligosaccharide catabolic process (GO:0009313)2.55512096
146positive regulation of lymphocyte migration (GO:2000403)2.55442939
147macrophage activation (GO:0042116)2.55311863
148positive regulation of interleukin-6 production (GO:0032755)2.54784968
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.54293245
150protein activation cascade (GO:0072376)2.53176540
151cytokine secretion (GO:0050663)2.52631622
152* negative regulation of coagulation (GO:0050819)2.52344643
153regulation of cellular extravasation (GO:0002691)2.51957335
154microglial cell activation (GO:0001774)2.51900402
155positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.51811239
156auditory receptor cell differentiation (GO:0042491)2.51563177
157dendritic cell chemotaxis (GO:0002407)2.51237160
158cellular response to virus (GO:0098586)2.51079652
159negative regulation of metanephros development (GO:0072217)2.50399647
160sterol transport (GO:0015918)2.50263642
161cholesterol transport (GO:0030301)2.50263642
162Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50182540
163cobalamin metabolic process (GO:0009235)2.49946610
164drug transport (GO:0015893)2.49721328
165fibrinolysis (GO:0042730)2.49623144
166positive regulation of glycoprotein biosynthetic process (GO:0010560)2.49284297
167digestion (GO:0007586)2.47546157
168low-density lipoprotein particle remodeling (GO:0034374)2.47079127
169very-low-density lipoprotein particle assembly (GO:0034379)2.46896301
170glycolipid catabolic process (GO:0019377)2.45628742
171negative regulation of wound healing (GO:0061045)2.45393508
172L-ascorbic acid metabolic process (GO:0019852)2.44600781
173fat-soluble vitamin biosynthetic process (GO:0042362)2.44380096
174lipoprotein metabolic process (GO:0042157)2.44315499
175glutathione biosynthetic process (GO:0006750)2.43371562
176sphingomyelin metabolic process (GO:0006684)2.41765014
177fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41118521
178high-density lipoprotein particle remodeling (GO:0034375)2.40714811
179regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.39851414
180endocrine process (GO:0050886)2.39851414
181regulation of systemic arterial blood pressure by hormone (GO:0001990)2.39851414
182negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.39454643
183regulation of extracellular matrix disassembly (GO:0010715)2.39249045
184virion attachment to host cell (GO:0019062)2.38744748
185adhesion of symbiont to host cell (GO:0044650)2.38744748
186nonribosomal peptide biosynthetic process (GO:0019184)2.37645338
187positive regulation of glycoprotein metabolic process (GO:1903020)2.37170809
188bile acid and bile salt transport (GO:0015721)2.36612665
189plasma lipoprotein particle remodeling (GO:0034369)2.36049792
190protein-lipid complex remodeling (GO:0034368)2.36049792
191macromolecular complex remodeling (GO:0034367)2.36049792
192phenylpropanoid metabolic process (GO:0009698)2.33337624
193regulation of extracellular matrix organization (GO:1903053)2.32541942
194pyrimidine-containing compound transmembrane transport (GO:0072531)2.31908912
195glutathione derivative biosynthetic process (GO:1901687)2.31243542
196glutathione derivative metabolic process (GO:1901685)2.31243542
197aromatic amino acid family catabolic process (GO:0009074)2.29460236
198glycosphingolipid catabolic process (GO:0046479)2.29070652

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.76288420
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.63714300
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.38845125
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.05870740
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.88039890
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.64089010
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62127493
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.53682300
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29485195
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.24439473
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14891279
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.82864495
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69274049
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48789729
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42404952
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38917918
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23659485
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.18787404
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.12548163
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09701338
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05118600
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.01333909
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00965487
24GATA1_22025678_ChIP-Seq_K562_Human1.97455386
25* SOX2_20726797_ChIP-Seq_SW620_Human1.93876708
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89563655
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85043605
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81037815
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73067616
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71379273
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68419331
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66790499
33* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66160151
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64001938
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.63498283
36* SPI1_23547873_ChIP-Seq_NB4_Human1.59332190
37* GATA4_25053715_ChIP-Seq_YYC3_Human1.57791336
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53856661
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.53546996
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.52943415
41* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50129397
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.48335659
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45376404
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.44780618
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43452279
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43394499
47VDR_24787735_ChIP-Seq_THP-1_Human1.43296639
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.43236123
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42599642
50PU_27001747_Chip-Seq_BMDM_Mouse1.41816043
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.38953119
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.38730440
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38625809
54* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38397342
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38397342
56AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37406396
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36880762
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36678471
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35965378
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35965378
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35793189
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34137166
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32910907
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28668827
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27545727
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26462347
67MYB_26560356_Chip-Seq_TH2_Human1.26427241
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24151390
69CJUN_26792858_Chip-Seq_BT549_Human1.22968286
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21939306
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21867664
72AHR_22903824_ChIP-Seq_MCF-7_Human1.20489150
73* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20440681
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.20384238
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20064036
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19249603
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.18854850
78TP53_16413492_ChIP-PET_HCT116_Human1.18654262
79* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18446275
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18045976
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17351384
82* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17196326
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16701762
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.16436282
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16433853
86TP53_18474530_ChIP-ChIP_U2OS_Human1.15565342
87VDR_24763502_ChIP-Seq_THP-1_Human1.14443692
88CDX2_22108803_ChIP-Seq_LS180_Human1.13751103
89* GATA6_25053715_ChIP-Seq_YYC3_Human1.12816852
90* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12622836
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12237648
92* TP63_23658742_ChIP-Seq_EP156T_Human1.11684512
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11076837
94* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09502210
95FOXA1_25552417_ChIP-Seq_VCAP_Human1.08327975
96SPI1_23127762_ChIP-Seq_K562_Human1.07592242
97* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07021664
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04732190
99GATA3_26560356_Chip-Seq_TH2_Human1.03842004
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02864111
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02332699
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01786040
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01760465
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00660723
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99818032
106TCF4_18268006_ChIP-ChIP_LS174T_Human0.99770067
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98153867
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98135228
109CLOCK_20551151_ChIP-Seq_293T_Human0.97946874
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97772511
111FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97050191
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96731115
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95729820
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.94670591
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93335019
116MYB_26560356_Chip-Seq_TH1_Human0.91877286
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91492431
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91005102
119GATA3_27048872_Chip-Seq_THYMUS_Human0.90373879
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90011239
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89307994
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89277343
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87518679
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86495996
125MAF_26560356_Chip-Seq_TH1_Human0.85611775
126RACK7_27058665_Chip-Seq_MCF-7_Human0.85060786
127ARNT_22903824_ChIP-Seq_MCF-7_Human0.84930951
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.83507612
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.82315780
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.82195258
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.82094597
132TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82026643
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81928912
134RUNX_20019798_ChIP-Seq_JUKART_Human0.81317252
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80836398
136FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80552307
137* KLF5_25053715_ChIP-Seq_YYC3_Human0.80305653
138ATF3_27146783_Chip-Seq_COLON_Human0.79072213
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76152538
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76083405
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74722521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.01005683
2MP0005365_abnormal_bile_salt3.64886826
3MP0002148_abnormal_hypersensitivity_rea3.39223623
4MP0003436_decreased_susceptibility_to3.29549965
5MP0009785_altered_susceptibility_to3.27497166
6MP0005085_abnormal_gallbladder_physiolo3.04704657
7MP0006082_CNS_inflammation2.64189402
8MP0003724_increased_susceptibility_to2.53995208
9MP0005058_abnormal_lysosome_morphology2.51546709
10MP0002419_abnormal_innate_immunity2.51377782
11MP0005000_abnormal_immune_tolerance2.49498237
12MP0005025_abnormal_response_to2.45419697
13MP0002132_abnormal_respiratory_system2.42568618
14MP0000685_abnormal_immune_system2.34417586
15MP0001790_abnormal_immune_system2.23151505
16MP0005387_immune_system_phenotype2.23151505
17MP0008875_abnormal_xenobiotic_pharmacok2.14640102
18MP0002876_abnormal_thyroid_physiology2.12952122
19MP0004782_abnormal_surfactant_physiolog2.10584110
20MP0005671_abnormal_response_to2.03940488
21MP0002138_abnormal_hepatobiliary_system2.03414367
22MP0005310_abnormal_salivary_gland2.02867224
23MP0002452_abnormal_antigen_presenting1.98067729
24MP0003300_gastrointestinal_ulcer1.95536588
25MP0010155_abnormal_intestine_physiology1.93043974
26MP0002877_abnormal_melanocyte_morpholog1.87831860
27MP0001533_abnormal_skeleton_physiology1.87634326
28MP0004947_skin_inflammation1.85611928
29MP0002723_abnormal_immune_serum1.82846183
30MP0002006_tumorigenesis1.80492868
31MP0009764_decreased_sensitivity_to1.79015852
32MP0003303_peritoneal_inflammation1.75560222
33MP0001845_abnormal_inflammatory_respons1.72530125
34MP0004043_abnormal_pH_regulation1.72053552
35MP0003183_abnormal_peptide_metabolism1.69925777
36MP0001800_abnormal_humoral_immune1.63638968
37MP0003191_abnormal_cellular_cholesterol1.62354387
38MP0005464_abnormal_platelet_physiology1.61865296
39MP0005332_abnormal_amino_acid1.61179177
40MP0001819_abnormal_immune_cell1.61150838
41MP0010329_abnormal_lipoprotein_level1.57341391
42MP0002254_reproductive_system_inflammat1.56588600
43MP0002405_respiratory_system_inflammati1.56211392
44MP0002420_abnormal_adaptive_immunity1.55855728
45MP0008469_abnormal_protein_level1.54518749
46MP0002166_altered_tumor_susceptibility1.53543218
47MP0008004_abnormal_stomach_pH1.51805706
48MP0003448_altered_tumor_morphology1.48666952
49MP0001664_abnormal_digestion1.47373463
50MP0005220_abnormal_exocrine_pancreas1.47197881
51MP0003806_abnormal_nucleotide_metabolis1.45887426
52MP0009840_abnormal_foam_cell1.45143446
53MP0001853_heart_inflammation1.44921779
54MP0003195_calcinosis1.42837519
55MP0010234_abnormal_vibrissa_follicle1.40648176
56MP0003868_abnormal_feces_composition1.39564735
57MP0002998_abnormal_bone_remodeling1.38897060
58MP0003950_abnormal_plasma_membrane1.37868097
59MP0000858_altered_metastatic_potential1.37135327
60MP0004510_myositis1.36248858
61MP0003186_abnormal_redox_activity1.34035272
62MP0005257_abnormal_intraocular_pressure1.32988475
63MP0004272_abnormal_basement_membrane1.31805169
64MP0009780_abnormal_chondrocyte_physiolo1.30459431
65MP0010352_gastrointestinal_tract_polyps1.30296588
66MP0005023_abnormal_wound_healing1.30036174
67MP0005379_endocrine/exocrine_gland_phen1.26801419
68MP0000343_altered_response_to1.26074912
69MP0003172_abnormal_lysosome_physiology1.24549058
70MP0001666_abnormal_nutrient_absorption1.24182988
71MP0002277_abnormal_respiratory_mucosa1.23645566
72MP0001873_stomach_inflammation1.22869544
73MP0000462_abnormal_digestive_system1.21666724
74MP0005166_decreased_susceptibility_to1.20196649
75MP0004264_abnormal_extraembryonic_tissu1.19782229
76MP0006054_spinal_hemorrhage1.19203685
77MP0003075_altered_response_to1.18963399
78MP0010678_abnormal_skin_adnexa1.18336364
79MP0003566_abnormal_cell_adhesion1.18026581
80MP0003866_abnormal_defecation1.17472239
81MP0002693_abnormal_pancreas_physiology1.16056496
82MP0008438_abnormal_cutaneous_collagen1.15733910
83MP0002089_abnormal_postnatal_growth/wei1.14438677
84MP0002928_abnormal_bile_duct1.12506901
85MP0003453_abnormal_keratinocyte_physiol1.08112396
86MP0002118_abnormal_lipid_homeostasis1.07673922
87MP0003045_fibrosis1.06848693
88MP0009333_abnormal_splenocyte_physiolog1.06776092
89* MP0010386_abnormal_urinary_bladder1.06650239
90MP0002139_abnormal_hepatobiliary_system1.04727245
91MP0003252_abnormal_bile_duct1.04047220
92MP0000716_abnormal_immune_system1.02957214
93MP0009643_abnormal_urine_homeostasis1.00904712
94MP0000490_abnormal_crypts_of0.99115426
95MP0001765_abnormal_ion_homeostasis0.97661692
96MP0005390_skeleton_phenotype0.96913796
97MP0005165_increased_susceptibility_to0.95413508
98MP0008872_abnormal_physiological_respon0.94725941
99MP0005167_abnormal_blood-brain_barrier0.94141559
100MP0005319_abnormal_enzyme/_coenzyme0.93803685
101MP0002136_abnormal_kidney_physiology0.93507247
102MP0002168_other_aberrant_phenotype0.92861929
103MP0003705_abnormal_hypodermis_morpholog0.92850888
104MP0004883_abnormal_blood_vessel0.91718793
105MP0005164_abnormal_response_to0.91207557
106MP0005408_hypopigmentation0.90155110
107MP0005636_abnormal_mineral_homeostasis0.89357962
108MP0000609_abnormal_liver_physiology0.88860212
109MP0005360_urolithiasis0.88286996
110MP0000613_abnormal_salivary_gland0.87916139
111MP0010307_abnormal_tumor_latency0.87606833
112MP0005076_abnormal_cell_differentiation0.87070143
113MP0005397_hematopoietic_system_phenotyp0.86547216
114MP0001545_abnormal_hematopoietic_system0.86547216
115MP0005083_abnormal_biliary_tract0.86222615
116MP0009763_increased_sensitivity_to0.85853575
117MP0003795_abnormal_bone_structure0.85349369
118MP0002933_joint_inflammation0.85119683
119MP0002163_abnormal_gland_morphology0.83747180
120MP0003283_abnormal_digestive_organ0.81963337
121MP0001663_abnormal_digestive_system0.81841261
122MP0004019_abnormal_vitamin_homeostasis0.81271969
123MP0005084_abnormal_gallbladder_morpholo0.79412288
124MP0002429_abnormal_blood_cell0.78661274
125MP0005275_abnormal_skin_tensile0.78593147
126MP0002796_impaired_skin_barrier0.78035536
127MP0009278_abnormal_bone_marrow0.77682706
128MP0002398_abnormal_bone_marrow0.77524023
129MP0005381_digestive/alimentary_phenotyp0.75915390
130MP0000249_abnormal_blood_vessel0.75528672
131MP0000477_abnormal_intestine_morphology0.74873751
132MP0000604_amyloidosis0.74745280
133MP0001958_emphysema0.74568169
134MP0000371_diluted_coat_color0.73320149
135MP0001881_abnormal_mammary_gland0.73234271
136MP0001764_abnormal_homeostasis0.73198452
137MP0001346_abnormal_lacrimal_gland0.72454377
138MP0000569_abnormal_digit_pigmentation0.71922412
139MP0001756_abnormal_urination0.71826129
140MP0001270_distended_abdomen0.68810979
141MP0002896_abnormal_bone_mineralization0.66344948
142MP0005595_abnormal_vascular_smooth0.66094641

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.81978230
2Recurrent abscess formation (HP:0002722)5.59640724
3Recurrent bacterial skin infections (HP:0005406)5.18498699
4Recurrent gram-negative bacterial infections (HP:0005420)5.07931939
5Vacuolated lymphocytes (HP:0001922)5.01697683
6Ileus (HP:0002595)4.54921993
7Abnormality of macrophages (HP:0004311)4.37662745
8Autoimmune thrombocytopenia (HP:0001973)4.27199429
9Interstitial pulmonary disease (HP:0006530)3.92044847
10Complement deficiency (HP:0004431)3.80796958
11Gingivitis (HP:0000230)3.75141569
12Fat malabsorption (HP:0002630)3.61852253
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.54248666
14Mediastinal lymphadenopathy (HP:0100721)3.50231572
15Vascular calcification (HP:0004934)3.49291454
16Malnutrition (HP:0004395)3.45335775
17Rectal prolapse (HP:0002035)3.43275130
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38464434
19Increased cerebral lipofuscin (HP:0011813)3.32449506
20Abnormality of complement system (HP:0005339)3.31418342
21Steatorrhea (HP:0002570)3.26776717
22Cardiovascular calcification (HP:0011915)3.25774724
23Periodontitis (HP:0000704)3.19858512
24Systemic lupus erythematosus (HP:0002725)3.12453970
25Increased neuronal autofluorescent lipopigment (HP:0002074)3.10301363
26Mitral stenosis (HP:0001718)3.09578076
27Recurrent skin infections (HP:0001581)3.07462989
28Orchitis (HP:0100796)3.06235735
29Myositis (HP:0100614)3.05947502
30Elevated erythrocyte sedimentation rate (HP:0003565)3.03749216
31Xanthomatosis (HP:0000991)3.01649698
32Urinary glycosaminoglycan excretion (HP:0003541)3.00008587
33Mucopolysacchariduria (HP:0008155)3.00008587
34Dysostosis multiplex (HP:0000943)2.99879549
35Recurrent fungal infections (HP:0002841)2.96735176
36Male infertility (HP:0003251)2.94404288
37Pustule (HP:0200039)2.92169466
38Basal ganglia calcification (HP:0002135)2.83614275
39Increased IgM level (HP:0003496)2.80066045
40Axonal loss (HP:0003447)2.79226442
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74196941
42Abnormality of polysaccharide metabolism (HP:0011012)2.74196941
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74196941
44Gout (HP:0001997)2.70907092
45Potter facies (HP:0002009)2.69156725
46Facial shape deformation (HP:0011334)2.69156725
47Conjugated hyperbilirubinemia (HP:0002908)2.67696975
48Azoospermia (HP:0000027)2.67514271
49Optic neuritis (HP:0100653)2.66689698
50Retrobulbar optic neuritis (HP:0100654)2.66689698
51Abnormality of glycolipid metabolism (HP:0010969)2.66297212
52Abnormality of liposaccharide metabolism (HP:0010968)2.66297212
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.66297212
54Glucose intolerance (HP:0000833)2.63305383
55Tetraparesis (HP:0002273)2.63038909
56Vasculitis (HP:0002633)2.60365434
57Thick nail (HP:0001805)2.59574624
58Abnormal glucose tolerance (HP:0001952)2.58334131
59Abnormal pancreas size (HP:0012094)2.56197951
60Intrahepatic cholestasis (HP:0001406)2.53768137
61Prostate neoplasm (HP:0100787)2.51783698
62Esophageal varix (HP:0002040)2.51489673
63Deep venous thrombosis (HP:0002625)2.48709383
64Hyperactive renin-angiotensin system (HP:0000841)2.47995371
65Autoimmune hemolytic anemia (HP:0001890)2.46715857
66Premature loss of primary teeth (HP:0006323)2.44664135
67Hypobetalipoproteinemia (HP:0003563)2.44502825
68Focal segmental glomerulosclerosis (HP:0000097)2.44427761
69Myocardial infarction (HP:0001658)2.43145083
70Late onset (HP:0003584)2.42684857
71Hydroxyprolinuria (HP:0003080)2.42454131
72Abnormality of proline metabolism (HP:0010907)2.42454131
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.40613055
74Osteolytic defects of the hand bones (HP:0009699)2.40613055
75Micronodular cirrhosis (HP:0001413)2.37630562
76Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31309324
77Glomerulonephritis (HP:0000099)2.30004125
78Glycosuria (HP:0003076)2.28932120
79Abnormality of urine glucose concentration (HP:0011016)2.28932120
80Recurrent viral infections (HP:0004429)2.28058963
81Chronic obstructive pulmonary disease (HP:0006510)2.27791670
82Obstructive lung disease (HP:0006536)2.27791670
83Glomerulosclerosis (HP:0000096)2.26280602
84Urticaria (HP:0001025)2.25808511
85Disinhibition (HP:0000734)2.23568650
86Renal tubular acidosis (HP:0001947)2.22077496
87Cheilitis (HP:0100825)2.21778736
88Hypergammaglobulinemia (HP:0010702)2.20768169
89Hemorrhage of the eye (HP:0011885)2.18793975
90Prolonged partial thromboplastin time (HP:0003645)2.17221072
91Recurrent pneumonia (HP:0006532)2.14109623
92Hematochezia (HP:0002573)2.13262051
93Osteomyelitis (HP:0002754)2.12398877
94Bone pain (HP:0002653)2.11798898
95Hypoplasia of the uterus (HP:0000013)2.11144835
96Pulmonary infiltrates (HP:0002113)2.10945669
97Flat acetabular roof (HP:0003180)2.09064867
98Vertebral compression fractures (HP:0002953)2.08483254
99Abnormality of vitamin metabolism (HP:0100508)2.07487803
100Increased CSF protein (HP:0002922)2.06504853
101Abnormality of the right ventricle (HP:0001707)2.05502787
102Chronic otitis media (HP:0000389)2.05252824
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05029181
104Arterial thrombosis (HP:0004420)2.02170739
105Pathologic fracture (HP:0002756)2.01142902
106Recurrent cutaneous fungal infections (HP:0011370)2.00432878
107Chronic mucocutaneous candidiasis (HP:0002728)2.00432878
108Nephritis (HP:0000123)2.00426999
109Gingival bleeding (HP:0000225)1.99385576
110Gastrointestinal infarctions (HP:0005244)1.99197674
111Tubulointerstitial fibrosis (HP:0005576)1.99036302
112Poor head control (HP:0002421)1.99026917
113Cellulitis (HP:0100658)1.98622099
114Amyloidosis (HP:0011034)1.98329713
115Abnormal biliary tract morphology (HP:0012440)1.98097287
116Abdominal distention (HP:0003270)1.96285959
117Right ventricular cardiomyopathy (HP:0011663)1.95961685
118Metabolic alkalosis (HP:0200114)1.95291780
119Petechiae (HP:0000967)1.94281890
120Stomatitis (HP:0010280)1.93106974
121Symptomatic seizures (HP:0011145)1.92777376
122Pigmentary retinal degeneration (HP:0001146)1.92750396
123Decreased circulating renin level (HP:0003351)1.90408318
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90307476
125Dehydration (HP:0001944)1.90104704
126Abnormality of the common coagulation pathway (HP:0010990)1.88645637
127Beaking of vertebral bodies (HP:0004568)1.87103586
128Hypoglycemic coma (HP:0001325)1.87005517
129Chronic diarrhea (HP:0002028)1.86876551
130Arterial tortuosity (HP:0005116)1.86861697
131Progressive visual loss (HP:0000529)1.85844103
132Hyperuricemia (HP:0002149)1.85415475
133Increased purine levels (HP:0004368)1.85415475
134Hyperammonemia (HP:0001987)1.83922506
135Congenital sensorineural hearing impairment (HP:0008527)1.83667756
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83327756
137Recurrent lower respiratory tract infections (HP:0002783)1.82005433
138Nausea (HP:0002018)1.81127130
139Joint hemorrhage (HP:0005261)1.80340507
140Loss of speech (HP:0002371)1.80083586
141Hypoglycemic seizures (HP:0002173)1.78249461
142Anorexia (HP:0002039)1.78093469
143Vascular tortuosity (HP:0004948)1.77903263
144Cervical subluxation (HP:0003308)1.77418754
145Abnormality of carpal bone ossification (HP:0006257)1.77114908
146Hemoptysis (HP:0002105)1.77011062
147Alkalosis (HP:0001948)1.76990789
148Alopecia of scalp (HP:0002293)1.76662114
149Hyperphosphatemia (HP:0002905)1.74343783
150Purpura (HP:0000979)1.74341360
151Hepatosplenomegaly (HP:0001433)1.74287776
152Abnormality of renin-angiotensin system (HP:0000847)1.73295900
153Exocrine pancreatic insufficiency (HP:0001738)1.72992582
154Abnormality of purine metabolism (HP:0004352)1.70049121
155Hypotension (HP:0002615)1.69947025
156Abnormality of the pericardium (HP:0001697)1.69768066
157Pancreatitis (HP:0001733)1.69273532
158Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68842075
159Leukocytosis (HP:0001974)1.68137488
160Bronchiectasis (HP:0002110)1.67849993
161Hypophosphatemia (HP:0002148)1.67410156
162Thrombocytosis (HP:0001894)1.67089242
163Prolonged neonatal jaundice (HP:0006579)1.64952713
164Abnormality of vitamin B metabolism (HP:0004340)1.64836471
165Hypolipoproteinemia (HP:0010981)1.62343623
166Abnormality of chloride homeostasis (HP:0011422)1.62267683
167J-shaped sella turcica (HP:0002680)1.60748484
168Rickets (HP:0002748)1.60525696
169Proximal tubulopathy (HP:0000114)1.57798177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.07689940
2PBK3.39884474
3RIPK43.21110186
4TBK13.17153070
5MST42.81832973
6BLK2.72721284
7FRK2.60748288
8IRAK32.52687246
9ERN12.52637217
10JAK32.38353028
11TYK22.36950752
12IRAK42.32027754
13MST1R2.26509705
14PIM22.08587478
15IKBKB2.07075964
16NEK92.06506528
17IKBKE2.02314166
18MAP3K121.98395462
19ACVR1B1.89028026
20MYLK1.78219698
21PIK3CA1.73851962
22JAK11.68097086
23NME21.66256834
24CHUK1.62018603
25STK391.61707168
26TAOK31.59070152
27EPHA21.56764761
28PIK3CG1.42813964
29ERBB31.40943562
30TRPM71.32435421
31KIT1.30869047
32MAP3K31.29442929
33MAPKAPK31.28278450
34PDK21.26507776
35RPS6KA41.22596617
36PTK61.19752590
37MAP3K21.17282704
38EPHA31.16190568
39INSRR1.14754712
40TESK11.14662649
41BMPR21.14511656
42MAP3K131.14178318
43EPHB11.09691647
44OXSR11.08457087
45ZAP701.05797047
46NUAK11.03953115
47PRKG20.99084128
48CSK0.98651720
49ABL20.95432661
50FGFR40.94412682
51MAP4K10.93263959
52JAK20.92983537
53RIPK10.92229496
54GRK10.91647545
55FLT30.91510012
56STK38L0.91294692
57BMX0.90700195
58MAP2K20.90603127
59SIK10.88938457
60MET0.87539096
61TGFBR20.87006570
62FGFR30.85830751
63SIK30.85455006
64BTK0.83293164
65PIM10.83239986
66AKT30.81235959
67BMPR1B0.79521800
68MAP2K60.78688873
69PDGFRA0.77689495
70TXK0.77667429
71TEC0.75357104
72LMTK20.74952351
73MATK0.73922088
74SYK0.73588183
75LRRK20.73066704
76EIF2AK20.71993925
77MAPK150.71556857
78STK100.70847020
79STK30.70052858
80CDC42BPA0.70043277
81CSF1R0.69578969
82MARK30.69393358
83MELK0.68814474
84LYN0.68243529
85MAPK110.66062965
86ADRBK20.65904480
87IRAK10.65898537
88ROCK10.63856573
89SCYL20.63711885
90PAK40.63157445
91PDPK10.63101582
92TRIB30.63076514
93PRKCD0.62530615
94YES10.60522093
95DYRK1B0.60370731
96STK40.57630413
97CDK80.56830232
98HCK0.56591529
99MAP3K10.56371886
100DAPK10.55887344
101PRKCE0.54739025
102PRKAA20.54239764
103TTN0.53944619
104NLK0.53610827
105ABL10.53424089
106LCK0.52270109
107ARAF0.51304817
108MAP3K50.48856640
109MAPKAPK20.48667773
110MAP2K30.48360228
111MAP3K110.45102934
112EPHB20.43903390
113FER0.43515298
114STK380.43330802
115EGFR0.43157122
116PTK20.42887113
117FGFR20.41097880
118PDK10.39952999
119HIPK20.39417770
120DAPK30.39170397
121GSK3A0.38719625
122BCR0.37437189
123ERBB40.37122828
124ERBB20.35604305
125LIMK10.35601573
126MAP2K10.34356416
127CDK60.34004770
128IGF1R0.33673086
129EIF2AK30.33624170
130PDGFRB0.32523108
131MAP3K70.32162215
132PRKACG0.32091706
133DDR20.32024052
134ILK0.30861532
135PRKCA0.29805641
136LATS10.29522345
137DAPK20.29378844
138PRKD20.29259041
139STK240.29121376
140SRC0.28765729
141ZAK0.28694634

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85288378
2Graft-versus-host disease_Homo sapiens_hsa053322.67783687
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.54381702
4Legionellosis_Homo sapiens_hsa051342.53094079
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.50937938
6Chemical carcinogenesis_Homo sapiens_hsa052042.37046688
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.35771593
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34370461
9Allograft rejection_Homo sapiens_hsa053302.24102803
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.18151056
11Lysosome_Homo sapiens_hsa041422.14903158
12Pertussis_Homo sapiens_hsa051332.11680490
13Retinol metabolism_Homo sapiens_hsa008302.10274993
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08467715
15Rheumatoid arthritis_Homo sapiens_hsa053232.08341503
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.07948515
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.07607055
18Staphylococcus aureus infection_Homo sapiens_hsa051502.05487233
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94157279
20Type I diabetes mellitus_Homo sapiens_hsa049401.88738196
21Tuberculosis_Homo sapiens_hsa051521.87034395
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86307484
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84740619
24TNF signaling pathway_Homo sapiens_hsa046681.77752110
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.77740008
26Malaria_Homo sapiens_hsa051441.77428416
27Other glycan degradation_Homo sapiens_hsa005111.77220599
28Osteoclast differentiation_Homo sapiens_hsa043801.75431058
29Phenylalanine metabolism_Homo sapiens_hsa003601.74386252
30Influenza A_Homo sapiens_hsa051641.68955972
31Phagosome_Homo sapiens_hsa041451.68406813
32Measles_Homo sapiens_hsa051621.65534461
33Bile secretion_Homo sapiens_hsa049761.64169538
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55922635
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.55797801
36Toxoplasmosis_Homo sapiens_hsa051451.53271720
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.53113425
38Salmonella infection_Homo sapiens_hsa051321.51723821
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49409577
40Fatty acid degradation_Homo sapiens_hsa000711.44575443
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.43737605
42Glutathione metabolism_Homo sapiens_hsa004801.38823454
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38242336
44Apoptosis_Homo sapiens_hsa042101.35391878
45Asthma_Homo sapiens_hsa053101.35106662
46Mineral absorption_Homo sapiens_hsa049781.34231752
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33158166
48Sulfur metabolism_Homo sapiens_hsa009201.31500332
49Arginine biosynthesis_Homo sapiens_hsa002201.31149763
50Pancreatic secretion_Homo sapiens_hsa049721.30082173
51Antigen processing and presentation_Homo sapiens_hsa046121.29792267
52African trypanosomiasis_Homo sapiens_hsa051431.27754484
53Tyrosine metabolism_Homo sapiens_hsa003501.26624710
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20258329
55Renin-angiotensin system_Homo sapiens_hsa046141.15837323
56Hematopoietic cell lineage_Homo sapiens_hsa046401.15283664
57Herpes simplex infection_Homo sapiens_hsa051681.15186733
58Hepatitis C_Homo sapiens_hsa051601.11766264
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11234407
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11087229
61Protein export_Homo sapiens_hsa030601.10970629
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10889371
63Glycerolipid metabolism_Homo sapiens_hsa005611.09634399
64PPAR signaling pathway_Homo sapiens_hsa033201.09380709
65Linoleic acid metabolism_Homo sapiens_hsa005911.09201960
66Shigellosis_Homo sapiens_hsa051311.08713825
67Vibrio cholerae infection_Homo sapiens_hsa051101.08549528
68Jak-STAT signaling pathway_Homo sapiens_hsa046301.04628650
69Autoimmune thyroid disease_Homo sapiens_hsa053201.04115484
70Leukocyte transendothelial migration_Homo sapiens_hsa046701.00025383
71Amoebiasis_Homo sapiens_hsa051460.99167050
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98339057
73Caffeine metabolism_Homo sapiens_hsa002320.95694537
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92004475
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90916600
76Chemokine signaling pathway_Homo sapiens_hsa040620.89315900
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89121793
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88936869
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87120119
80beta-Alanine metabolism_Homo sapiens_hsa004100.82265169
81Fat digestion and absorption_Homo sapiens_hsa049750.82182879
82Histidine metabolism_Homo sapiens_hsa003400.82100854
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82048985
84Nitrogen metabolism_Homo sapiens_hsa009100.81893244
85Arginine and proline metabolism_Homo sapiens_hsa003300.81081658
86Hepatitis B_Homo sapiens_hsa051610.78222343
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78137813
88Folate biosynthesis_Homo sapiens_hsa007900.77908705
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77470218
90Collecting duct acid secretion_Homo sapiens_hsa049660.76345941
91B cell receptor signaling pathway_Homo sapiens_hsa046620.75092236
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75018592
93Galactose metabolism_Homo sapiens_hsa000520.73509679
94Viral myocarditis_Homo sapiens_hsa054160.73289176
95Peroxisome_Homo sapiens_hsa041460.73166271
96Starch and sucrose metabolism_Homo sapiens_hsa005000.72778604
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71261922
98Sphingolipid metabolism_Homo sapiens_hsa006000.71078532
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69629997
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67461216
101Ether lipid metabolism_Homo sapiens_hsa005650.65848556
102Prolactin signaling pathway_Homo sapiens_hsa049170.65749111
103Complement and coagulation cascades_Homo sapiens_hsa046100.63880515
104Vitamin digestion and absorption_Homo sapiens_hsa049770.61036557
105Butanoate metabolism_Homo sapiens_hsa006500.56847501
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54585669
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52151747
108Small cell lung cancer_Homo sapiens_hsa052220.51116153
109Acute myeloid leukemia_Homo sapiens_hsa052210.50621067
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49776370
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48311235
112Protein digestion and absorption_Homo sapiens_hsa049740.47977713
113Adherens junction_Homo sapiens_hsa045200.47923933
114Steroid biosynthesis_Homo sapiens_hsa001000.47323042
115Tryptophan metabolism_Homo sapiens_hsa003800.47160199
116Arachidonic acid metabolism_Homo sapiens_hsa005900.45263950
117Prion diseases_Homo sapiens_hsa050200.44934580
118Thyroid hormone synthesis_Homo sapiens_hsa049180.43611373
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43202641
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42687602
121Chronic myeloid leukemia_Homo sapiens_hsa052200.41055468
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40731320
123Pancreatic cancer_Homo sapiens_hsa052120.39280390
124Pentose phosphate pathway_Homo sapiens_hsa000300.38324046
125N-Glycan biosynthesis_Homo sapiens_hsa005100.37220024
126Insulin resistance_Homo sapiens_hsa049310.36781525
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36032159
128Platelet activation_Homo sapiens_hsa046110.35365355
129ECM-receptor interaction_Homo sapiens_hsa045120.35356134
130Fatty acid metabolism_Homo sapiens_hsa012120.35353468
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.35113278
132ABC transporters_Homo sapiens_hsa020100.34716947
133Vitamin B6 metabolism_Homo sapiens_hsa007500.33654569
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.32904864
135Primary immunodeficiency_Homo sapiens_hsa053400.30949391
136Tight junction_Homo sapiens_hsa045300.30508779
137Proteoglycans in cancer_Homo sapiens_hsa052050.29898727
138Type II diabetes mellitus_Homo sapiens_hsa049300.29628699
139Fatty acid elongation_Homo sapiens_hsa000620.28553471
140Metabolic pathways_Homo sapiens_hsa011000.27967995
141Fructose and mannose metabolism_Homo sapiens_hsa000510.27436486
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26479521
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24877228

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