ANXA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)4.31054655
2neutrophil activation involved in immune response (GO:0002283)4.27167038
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13123154
4protein localization to endosome (GO:0036010)4.11576712
5regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.76372349
6extracellular fibril organization (GO:0043206)3.69478464
7melanin metabolic process (GO:0006582)3.68521810
8cell adhesion mediated by integrin (GO:0033627)3.64974399
9regulation of vitamin D biosynthetic process (GO:0060556)3.54639561
10COPI coating of Golgi vesicle (GO:0048205)3.50112025
11Golgi transport vesicle coating (GO:0048200)3.50112025
12secondary metabolite biosynthetic process (GO:0044550)3.47006202
13regulation of membrane protein ectodomain proteolysis (GO:0051043)3.45458044
14fibril organization (GO:0097435)3.44816970
15pinocytosis (GO:0006907)3.43822964
16membrane budding (GO:0006900)3.43244049
17negative regulation of nitric oxide biosynthetic process (GO:0045019)3.43198281
18hyaluronan catabolic process (GO:0030214)3.43017473
19regulation of early endosome to late endosome transport (GO:2000641)3.42918784
20substrate-dependent cell migration (GO:0006929)3.40146277
21positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.39698551
22virion attachment to host cell (GO:0019062)3.38520401
23adhesion of symbiont to host cell (GO:0044650)3.38520401
24stress fiber assembly (GO:0043149)3.36494755
25retina vasculature morphogenesis in camera-type eye (GO:0061299)3.35358786
26negative regulation of smooth muscle cell migration (GO:0014912)3.28750648
27signal peptide processing (GO:0006465)3.26782979
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22720994
29protein heterotrimerization (GO:0070208)3.17869964
30membrane raft organization (GO:0031579)3.16700672
31regulation of integrin-mediated signaling pathway (GO:2001044)3.12883127
32keratan sulfate catabolic process (GO:0042340)3.10742620
33type B pancreatic cell proliferation (GO:0044342)3.08414977
34cell migration involved in heart development (GO:0060973)3.03940532
35cellular response to nicotine (GO:0071316)3.03699114
36regulation of monocyte chemotaxis (GO:0090025)3.01074804
37basement membrane organization (GO:0071711)2.99013432
38positive regulation of extracellular matrix organization (GO:1903055)2.98405141
39bundle of His cell to Purkinje myocyte communication (GO:0086069)2.98058328
40wound healing, spreading of epidermal cells (GO:0035313)2.94151043
41positive regulation of receptor recycling (GO:0001921)2.93148095
42adhesion of symbiont to host (GO:0044406)2.92869028
43protein retention in ER lumen (GO:0006621)2.91366641
44peptidyl-proline hydroxylation (GO:0019511)2.90570381
45collagen fibril organization (GO:0030199)2.88633426
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.87818228
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.87818228
48modulation by symbiont of host immune response (GO:0052553)2.87818228
49positive regulation by symbiont of host defense response (GO:0052509)2.87818228
50modulation by symbiont of host defense response (GO:0052031)2.87818228
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.87818228
52glycosphingolipid catabolic process (GO:0046479)2.87151645
53positive regulation of endothelial cell apoptotic process (GO:2000353)2.85856447
54protein hydroxylation (GO:0018126)2.85035035
55COPII vesicle coating (GO:0048208)2.83997471
56positive regulation of monocyte chemotaxis (GO:0090026)2.83406406
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.83003047
58positive regulation of heat generation (GO:0031652)2.82716149
59negative regulation of nitric-oxide synthase activity (GO:0051001)2.82654042
60low-density lipoprotein particle clearance (GO:0034383)2.81765339
61regulation of vitamin metabolic process (GO:0030656)2.81304067
62regulation of mononuclear cell migration (GO:0071675)2.81069797
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80737810
64cellular response to ATP (GO:0071318)2.75508152
65regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74993070
66sequestering of extracellular ligand from receptor (GO:0035581)2.74565480
67negative regulation of protein localization to plasma membrane (GO:1903077)2.73409888
68mesenchymal-epithelial cell signaling (GO:0060638)2.71304749
69apoptotic cell clearance (GO:0043277)2.70669985
70cellular response to interferon-alpha (GO:0035457)2.70364830
71detection of temperature stimulus involved in sensory perception (GO:0050961)2.68362359
72detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.68362359
73decidualization (GO:0046697)2.67532542
74negative regulation of chondrocyte differentiation (GO:0032331)2.65697663
75positive regulation of natural killer cell differentiation (GO:0032825)2.65369911
76UDP-N-acetylglucosamine metabolic process (GO:0006047)2.65330788
77sequestering of metal ion (GO:0051238)2.64264160
78oligosaccharide catabolic process (GO:0009313)2.63436667
79regulation of cytokine secretion involved in immune response (GO:0002739)2.63101618
80glycolipid catabolic process (GO:0019377)2.61738008
81granulocyte activation (GO:0036230)2.60691208
82positive regulation of p38MAPK cascade (GO:1900745)2.60563940
83endothelial cell morphogenesis (GO:0001886)2.60143275
84respiratory burst (GO:0045730)2.60037359
85neutrophil activation (GO:0042119)2.56791361
86positive regulation of chemokine biosynthetic process (GO:0045080)2.55706264
87positive regulation of interferon-alpha production (GO:0032727)2.55270477
88cortical actin cytoskeleton organization (GO:0030866)2.53551542
89collagen catabolic process (GO:0030574)2.52697036
90regulation of fever generation (GO:0031620)2.52618273
91cellular response to thyroid hormone stimulus (GO:0097067)2.52603877
92positive regulation of protein autophosphorylation (GO:0031954)2.52121598
93collagen metabolic process (GO:0032963)2.51552559
94positive regulation of actin filament depolymerization (GO:0030836)2.50498628
95positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.48382003
96cellular response to vitamin (GO:0071295)2.48349401
97dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48033912
98monocyte chemotaxis (GO:0002548)2.47915942
99substrate adhesion-dependent cell spreading (GO:0034446)2.47315375
100cellular copper ion homeostasis (GO:0006878)2.47136050
101positive regulation of macrophage cytokine production (GO:0060907)2.46654264
102regulation of extracellular matrix disassembly (GO:0010715)2.45666678
103protein maturation by protein folding (GO:0022417)2.44184754
104response to interferon-alpha (GO:0035455)2.44176588
105endodermal cell differentiation (GO:0035987)2.44170067
106negative regulation of anoikis (GO:2000811)2.44074847
107negative regulation of monooxygenase activity (GO:0032769)2.44070830
108response to hyperoxia (GO:0055093)2.43919479
109response to increased oxygen levels (GO:0036296)2.43919479
110negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.43706960
111proteasome assembly (GO:0043248)2.43334195
112glial cell migration (GO:0008347)2.43196634
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.43003734
114regulation of podosome assembly (GO:0071801)2.42627616
115sequestering of actin monomers (GO:0042989)2.42066502
116regulation of type B pancreatic cell apoptotic process (GO:2000674)2.42032772
117response to peptidoglycan (GO:0032494)2.41219070
118membrane protein ectodomain proteolysis (GO:0006509)2.40598589
119wound healing, spreading of cells (GO:0044319)2.40168611
120macrophage activation involved in immune response (GO:0002281)2.39861529
121vesicle coating (GO:0006901)2.39272677
122protein localization to cell surface (GO:0034394)2.39138947
123regulation of interferon-alpha production (GO:0032647)2.38385900
124fibrinolysis (GO:0042730)2.38356014
125extracellular matrix assembly (GO:0085029)2.37849202
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.37053907
127regulation of interferon-beta biosynthetic process (GO:0045357)2.37037622
128detection of temperature stimulus (GO:0016048)2.35239838
129response to thyroid hormone (GO:0097066)2.35143418
130regulation of macrophage cytokine production (GO:0010935)2.35092926
131hemidesmosome assembly (GO:0031581)2.33706572
132negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.30872668
133multicellular organismal macromolecule metabolic process (GO:0044259)2.30197319
134multicellular organismal catabolic process (GO:0044243)2.29963362
135extracellular matrix disassembly (GO:0022617)2.29962312
136negative regulation of lipid storage (GO:0010888)2.29691591
137positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.29602644
138regulation of T cell migration (GO:2000404)2.29105011
139regulation of metalloenzyme activity (GO:0048552)2.28453754
140positive regulation of T cell migration (GO:2000406)2.28172909
141hydrogen peroxide biosynthetic process (GO:0050665)2.27681054
142barbed-end actin filament capping (GO:0051016)2.27673250
143cellular response to vitamin D (GO:0071305)2.27188748
144positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25503752
145antigen processing and presentation of endogenous antigen (GO:0019883)2.24496116
146peripheral nervous system neuron development (GO:0048935)2.21870011
147chondrocyte proliferation (GO:0035988)2.20851060
148negative regulation of fatty acid transport (GO:2000192)2.20739617
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20728685
150multicellular organismal metabolic process (GO:0044236)2.20223673
151response to water (GO:0009415)2.20026570
152phospholipid scrambling (GO:0017121)2.19408112
153endosome to melanosome transport (GO:0035646)2.19013743
154endosome to pigment granule transport (GO:0043485)2.19013743
155skin morphogenesis (GO:0043589)2.18477881
156regulation of T-helper 1 cell differentiation (GO:0045625)2.17675210
157eosinophil chemotaxis (GO:0048245)2.17658253
158negative regulation of bone resorption (GO:0045779)2.17553199
159natural killer cell mediated cytotoxicity (GO:0042267)2.17003103
160natural killer cell mediated immunity (GO:0002228)2.17003103
161positive regulation of macrophage differentiation (GO:0045651)2.16776474
162regulation of antigen processing and presentation (GO:0002577)2.16229197
163regulation of cholesterol storage (GO:0010885)2.15241563
164positive regulation of cellular amide metabolic process (GO:0034250)2.15225702
165lipopolysaccharide-mediated signaling pathway (GO:0031663)2.14766847
166phagocytosis, recognition (GO:0006910)2.13768830
167response to lipoprotein particle (GO:0055094)2.13427128
168positive regulation of lymphocyte migration (GO:2000403)2.12164887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.94092701
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.63002513
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.01257453
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.00943626
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.32482750
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.86725058
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72231186
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.59836429
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.58266772
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57732393
11CLOCK_20551151_ChIP-Seq_293T_Human2.37203933
12GATA1_22025678_ChIP-Seq_K562_Human2.30167939
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.29796675
14* CJUN_26792858_Chip-Seq_BT549_Human2.28841440
15* SOX2_20726797_ChIP-Seq_SW620_Human2.21297139
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.16724762
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14614911
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.14512983
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13471884
20GATA2_21666600_ChIP-Seq_HMVEC_Human2.13380122
21NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.08079145
22NRF2_20460467_ChIP-Seq_MEFs_Mouse2.08079145
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.07672505
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07248026
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05906212
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99348544
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95963028
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94321849
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91200291
30AR_21909140_ChIP-Seq_LNCAP_Human1.90904817
31TFEB_21752829_ChIP-Seq_HELA_Human1.88871385
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88676291
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84548610
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81488226
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81488226
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.78849405
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.76817963
38CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76513422
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74423234
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.71087609
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70332579
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.65967043
43* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.65632175
44* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60358704
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57223868
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56542467
47* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55852423
48* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55831341
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.48578230
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.46841689
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46737585
52* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46481360
53VDR_24787735_ChIP-Seq_THP-1_Human1.46226462
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.45102633
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40809897
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.39837538
57NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38885695
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38464933
59* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35424276
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35075585
61ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34009588
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33265838
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29919995
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.29835278
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28628462
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28568172
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24351154
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23375498
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21353192
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17580403
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16461138
72* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16343759
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16094774
74BRD4_25478319_ChIP-Seq_HGPS_Human1.15868093
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15662769
76TP53_18474530_ChIP-ChIP_U2OS_Human1.15387395
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15014961
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.13909589
79SOX17_20123909_ChIP-Seq_XEN_Mouse1.11003055
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10539550
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.07548681
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07172524
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07061802
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06550405
85TP63_23658742_ChIP-Seq_EP156T_Human1.01006621
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00365134
87GATA4_25053715_ChIP-Seq_YYC3_Human0.99663803
88* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99339900
89GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99279288
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.98122647
91EGR1_19032775_ChIP-ChIP_M12_Human0.97953616
92ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97681533
93RXR_22158963_ChIP-Seq_LIVER_Mouse0.97509158
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96918636
95ELK1_19687146_ChIP-ChIP_HELA_Human0.96628886
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96208969
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95777545
98SPI1_23127762_ChIP-Seq_K562_Human0.93075571
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92959009
100ZNF263_19887448_ChIP-Seq_K562_Human0.91204879
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91107986
102* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91013392
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90308214
104PU_27001747_Chip-Seq_BMDM_Mouse0.89478357
105SA1_22415368_ChIP-Seq_MEFs_Mouse0.88950917
106SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88434420
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.88285333
108VDR_24763502_ChIP-Seq_THP-1_Human0.87795001
109NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87753380
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87393633
111NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87337409
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85988203
113* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85782415
114NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85677746
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85540933
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85187029
117* ELK1_22589737_ChIP-Seq_MCF10A_Human0.84813682
118* TBX20_22080862_ChIP-Seq_HEART_Mouse0.84736831
119* TBX20_22328084_ChIP-Seq_HEART_Mouse0.84736831
120* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83833602
121EOMES_21245162_ChIP-Seq_HESCs_Human0.83616045
122* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82980218
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82263432
124TP53_22127205_ChIP-Seq_IMR90_Human0.80910498
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77719621
126ATF3_27146783_Chip-Seq_COLON_Human0.76514621
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76029366
128GATA3_26560356_Chip-Seq_TH2_Human0.75991253
129SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75547716
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74808965
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74387048
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73347060

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.54202222
2MP0003950_abnormal_plasma_membrane3.52330344
3MP0005171_absent_coat_pigmentation3.14829128
4MP0005275_abnormal_skin_tensile2.80826556
5MP0003279_aneurysm2.41806891
6MP0002877_abnormal_melanocyte_morpholog2.41183613
7MP0005058_abnormal_lysosome_morphology2.36771650
8MP0005503_abnormal_tendon_morphology2.36638445
9MP0001542_abnormal_bone_strength2.26735794
10MP0004272_abnormal_basement_membrane2.25808145
11MP0001958_emphysema2.20946747
12MP0003436_decreased_susceptibility_to2.19151065
13MP0001835_abnormal_antigen_presentation2.18156226
14MP0003566_abnormal_cell_adhesion2.13814008
15MP0001533_abnormal_skeleton_physiology2.13162625
16MP0009785_altered_susceptibility_to2.11652749
17MP0009840_abnormal_foam_cell1.97770472
18MP0004858_abnormal_nervous_system1.92239882
19MP0004782_abnormal_surfactant_physiolog1.91955728
20MP0003724_increased_susceptibility_to1.91462070
21MP0003705_abnormal_hypodermis_morpholog1.91190602
22MP0003806_abnormal_nucleotide_metabolis1.89828517
23MP0000343_altered_response_to1.72852231
24* MP0002148_abnormal_hypersensitivity_rea1.72724375
25MP0002735_abnormal_chemical_nociception1.72084735
26MP0002419_abnormal_innate_immunity1.71951923
27MP0000685_abnormal_immune_system1.71329483
28MP0002295_abnormal_pulmonary_circulatio1.70307203
29MP0002933_joint_inflammation1.69585635
30MP0002998_abnormal_bone_remodeling1.66621918
31MP0010386_abnormal_urinary_bladder1.61756271
32MP0003172_abnormal_lysosome_physiology1.60370274
33MP0006082_CNS_inflammation1.58550390
34MP0000371_diluted_coat_color1.55011070
35MP0001986_abnormal_taste_sensitivity1.54533348
36MP0004510_myositis1.53658682
37MP0005023_abnormal_wound_healing1.51197696
38MP0005390_skeleton_phenotype1.48773522
39MP0005000_abnormal_immune_tolerance1.47447700
40MP0005164_abnormal_response_to1.47199409
41MP0002896_abnormal_bone_mineralization1.45969690
42MP0003300_gastrointestinal_ulcer1.42245836
43MP0006054_spinal_hemorrhage1.38998832
44MP0003186_abnormal_redox_activity1.38383143
45MP0000372_irregular_coat_pigmentation1.37938508
46MP0001299_abnormal_eye_distance/1.37792340
47MP0005257_abnormal_intraocular_pressure1.37674142
48MP0001348_abnormal_lacrimal_gland1.34912018
49MP0001790_abnormal_immune_system1.34764680
50MP0005387_immune_system_phenotype1.34764680
51MP0002736_abnormal_nociception_after1.31645906
52MP0000015_abnormal_ear_pigmentation1.31309813
53MP0003091_abnormal_cell_migration1.29331338
54MP0009384_cardiac_valve_regurgitation1.29308212
55MP0005197_abnormal_uvea_morphology1.27595152
56MP0003941_abnormal_skin_development1.27563426
57MP0003045_fibrosis1.22778258
58MP0001968_abnormal_touch/_nociception1.21689234
59MP0001879_abnormal_lymphatic_vessel1.21132522
60MP0003795_abnormal_bone_structure1.20776272
61MP0005595_abnormal_vascular_smooth1.19218371
62MP0000013_abnormal_adipose_tissue1.18223728
63MP0005025_abnormal_response_to1.18084860
64MP0000858_altered_metastatic_potential1.17786804
65MP0003195_calcinosis1.17780902
66MP0005623_abnormal_meninges_morphology1.17748530
67MP0002405_respiratory_system_inflammati1.16368207
68MP0003448_altered_tumor_morphology1.14105786
69MP0001270_distended_abdomen1.14065286
70MP0002254_reproductive_system_inflammat1.13757978
71MP0008260_abnormal_autophagy1.11097358
72MP0005508_abnormal_skeleton_morphology1.10639299
73MP0000163_abnormal_cartilage_morphology1.10316194
74MP0001853_heart_inflammation1.09339409
75MP0003191_abnormal_cellular_cholesterol1.08130553
76MP0004883_abnormal_blood_vessel1.06998671
77MP0004134_abnormal_chest_morphology1.06254313
78MP0004947_skin_inflammation1.05996911
79MP0008004_abnormal_stomach_pH1.04003121
80MP0002115_abnormal_skeleton_extremities1.01857839
81MP0005464_abnormal_platelet_physiology1.01409048
82MP0010368_abnormal_lymphatic_system1.01106140
83MP0000538_abnormal_urinary_bladder1.00909508
84MP0003453_abnormal_keratinocyte_physiol1.00692948
85MP0002168_other_aberrant_phenotype1.00335006
86MP0004233_abnormal_muscle_weight1.00220366
87MP0000767_abnormal_smooth_muscle1.00187808
88MP0002060_abnormal_skin_morphology0.99840158
89MP0009764_decreased_sensitivity_to0.99745580
90MP0003828_pulmonary_edema0.99531017
91MP0002452_abnormal_antigen_presenting0.97702860
92MP0003075_altered_response_to0.96606641
93MP0001915_intracranial_hemorrhage0.95875557
94MP0003303_peritoneal_inflammation0.95848775
95* MP0001845_abnormal_inflammatory_respons0.94357775
96MP0003136_yellow_coat_color0.93943547
97MP0002090_abnormal_vision0.93778727
98MP0002282_abnormal_trachea_morphology0.93005426
99MP0001849_ear_inflammation0.92702249
100MP0010030_abnormal_orbit_morphology0.92561684
101MP0002733_abnormal_thermal_nociception0.91029993
102MP0003183_abnormal_peptide_metabolism0.89650432
103MP0005165_increased_susceptibility_to0.89445429
104MP0000249_abnormal_blood_vessel0.89233925
105MP0002113_abnormal_skeleton_development0.88827306
106MP0009780_abnormal_chondrocyte_physiolo0.88201453
107MP0000749_muscle_degeneration0.86752831
108MP0009250_abnormal_appendicular_skeleto0.85554942
109MP0001186_pigmentation_phenotype0.85329898
110MP0009278_abnormal_bone_marrow0.84236084
111MP0005083_abnormal_biliary_tract0.83638715
112MP0000604_amyloidosis0.83522850
113MP0000733_abnormal_muscle_development0.83333128
114MP0005193_abnormal_anterior_eye0.83053179
115MP0005166_decreased_susceptibility_to0.82245033
116MP0002138_abnormal_hepatobiliary_system0.82081771
117MP0010352_gastrointestinal_tract_polyps0.81065787
118* MP0002723_abnormal_immune_serum0.80968791
119MP0005408_hypopigmentation0.80772935
120MP0008469_abnormal_protein_level0.79843470
121MP0002075_abnormal_coat/hair_pigmentati0.79099353
122MP0001243_abnormal_dermal_layer0.77700058
123MP0002332_abnormal_exercise_endurance0.72534837
124MP0000751_myopathy0.72271005
125MP0000569_abnormal_digit_pigmentation0.70044921
126MP0010234_abnormal_vibrissa_follicle0.62885615
127MP0002095_abnormal_skin_pigmentation0.61185576
128MP0005621_abnormal_cell_physiology0.57904566
129MP0001324_abnormal_eye_pigmentation0.57479874
130MP0000920_abnormal_myelination0.55527545
131MP0001614_abnormal_blood_vessel0.54258657
132MP0000759_abnormal_skeletal_muscle0.53258784
133MP0002108_abnormal_muscle_morphology0.52583353
134MP0005174_abnormal_tail_pigmentation0.52431484

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)4.59293586
2Abnormality of proline metabolism (HP:0010907)4.05523097
3Hydroxyprolinuria (HP:0003080)4.05523097
4Premature rupture of membranes (HP:0001788)4.01735351
5Epiphyseal dysplasia (HP:0002656)3.90587490
6Protrusio acetabuli (HP:0003179)3.51125009
7Eczematoid dermatitis (HP:0000976)3.35939711
8Cervical subluxation (HP:0003308)3.34512184
9Beaking of vertebral bodies (HP:0004568)3.23371021
10Vacuolated lymphocytes (HP:0001922)3.16794575
11Dysostosis multiplex (HP:0000943)3.02553914
12Tetraparesis (HP:0002273)3.02387476
13Atrophic scars (HP:0001075)2.98368111
14Increased cerebral lipofuscin (HP:0011813)2.87266241
15Thoracolumbar scoliosis (HP:0002944)2.83890845
16Short nail (HP:0001799)2.82132258
17Recurrent abscess formation (HP:0002722)2.79539569
18Nuclear cataract (HP:0100018)2.79175300
19Cupped ribs (HP:0000887)2.78722821
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.75789624
21Osteolytic defects of the hand bones (HP:0009699)2.75789624
22Wormian bones (HP:0002645)2.74483468
23Bladder diverticulum (HP:0000015)2.73864812
24Interstitial pulmonary disease (HP:0006530)2.71419997
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.68328301
26Abnormality of dentin (HP:0010299)2.67923490
27Axonal loss (HP:0003447)2.67643711
28Mucopolysacchariduria (HP:0008155)2.66773911
29Urinary glycosaminoglycan excretion (HP:0003541)2.66773911
30White forelock (HP:0002211)2.66073957
31Patchy hypopigmentation of hair (HP:0011365)2.60825272
32Cardiovascular calcification (HP:0011915)2.58865454
33Mitral stenosis (HP:0001718)2.56614008
34Reduced subcutaneous adipose tissue (HP:0003758)2.56037053
35Ovoid vertebral bodies (HP:0003300)2.54660451
36Peritonitis (HP:0002586)2.49693690
37Aortic dissection (HP:0002647)2.45097240
38Recurrent bacterial skin infections (HP:0005406)2.44350239
39Neonatal short-limb short stature (HP:0008921)2.43960390
40Osteoarthritis (HP:0002758)2.43803225
41Segmental peripheral demyelination/remyelination (HP:0003481)2.42763337
42Metaphyseal dysplasia (HP:0100255)2.40843689
43Loss of speech (HP:0002371)2.39781196
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39355164
45Abnormality of polysaccharide metabolism (HP:0011012)2.39355164
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39355164
47Abnormality of macrophages (HP:0004311)2.38138324
48Irregular epiphyses (HP:0010582)2.37749144
49Spinal rigidity (HP:0003306)2.37481628
50Elbow flexion contracture (HP:0002987)2.35625861
51Abnormality of the ischium (HP:0003174)2.33292309
52Genu recurvatum (HP:0002816)2.32728374
53Follicular hyperkeratosis (HP:0007502)2.31459469
54Platyspondyly (HP:0000926)2.30207546
55Protuberant abdomen (HP:0001538)2.29953541
56Abnormality of the lumbar spine (HP:0100712)2.29411075
57Aortic aneurysm (HP:0004942)2.27630045
58Slender build (HP:0001533)2.25957151
59Vascular tortuosity (HP:0004948)2.25383609
60Coxa vara (HP:0002812)2.24352596
61Generalized amyotrophy (HP:0003700)2.23165612
62Hypoplasia of the odontoid process (HP:0003311)2.22887235
63Ulnar claw (HP:0001178)2.21750021
64Hypoplastic ischia (HP:0003175)2.19875436
65Fragile skin (HP:0001030)2.19634621
66Joint stiffness (HP:0001387)2.19330125
67Type 1 muscle fiber predominance (HP:0003803)2.18688716
68Flat acetabular roof (HP:0003180)2.17103762
69Vitreoretinal degeneration (HP:0000655)2.16114531
70Biconcave vertebral bodies (HP:0004586)2.14761552
71Recurrent gram-negative bacterial infections (HP:0005420)2.11493547
72Soft skin (HP:0000977)2.09852619
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08860769
74Myocardial infarction (HP:0001658)2.08529495
75Albinism (HP:0001022)2.07847614
76Autoimmune thrombocytopenia (HP:0001973)2.07682290
77Hypoplasia of the iris (HP:0007676)2.06680113
78Absent frontal sinuses (HP:0002688)2.06294583
79Arterial tortuosity (HP:0005116)2.06127029
80Abnormality of glycolipid metabolism (HP:0010969)2.04986358
81Abnormality of liposaccharide metabolism (HP:0010968)2.04986358
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.04986358
83Delayed cranial suture closure (HP:0000270)2.04122053
84Aortic regurgitation (HP:0001659)2.03982224
85Shallow orbits (HP:0000586)2.03336767
86Abnormal delivery (HP:0001787)2.02526578
87Pathologic fracture (HP:0002756)2.02445819
88Delayed closure of the anterior fontanelle (HP:0001476)2.01880701
89Systemic lupus erythematosus (HP:0002725)2.01183676
90Increased connective tissue (HP:0009025)2.00534058
91Abnormality of the odontoid process (HP:0003310)2.00264737
92Disproportionate short-trunk short stature (HP:0003521)1.99898656
93Ocular albinism (HP:0001107)1.99868212
94Natal tooth (HP:0000695)1.99599729
95Vascular calcification (HP:0004934)1.98510471
96Flat capital femoral epiphysis (HP:0003370)1.98021189
97Dysautonomia (HP:0002459)1.96453467
98Hypothermia (HP:0002045)1.96113517
99Ankle contracture (HP:0006466)1.96099511
100Dilatation of the ascending aorta (HP:0005111)1.95997395
101Autoamputation (HP:0001218)1.94895187
102Hyperextensible skin (HP:0000974)1.94548944
103Abnormal tarsal ossification (HP:0008369)1.94318142
104Aortic valve stenosis (HP:0001650)1.94050054
105Broad metatarsal (HP:0001783)1.93946184
106Abnormality of the acetabulum (HP:0003170)1.92869269
107Abnormality of the vertebral endplates (HP:0005106)1.91525737
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91276661
109Spondylolisthesis (HP:0003302)1.91102068
110Mitral regurgitation (HP:0001653)1.90524700
111Amyloidosis (HP:0011034)1.90163309
112Aplasia/Hypoplasia of the macula (HP:0008059)1.89269348
113Elevated erythrocyte sedimentation rate (HP:0003565)1.88327263
114Neurofibrillary tangles (HP:0002185)1.88087317
115Blue sclerae (HP:0000592)1.87825527
116Lumbar hyperlordosis (HP:0002938)1.86945809
117Nonimmune hydrops fetalis (HP:0001790)1.85616027
118Cerebral aneurysm (HP:0004944)1.85592850
119Abnormality of the umbilical cord (HP:0010881)1.85213493
120Joint laxity (HP:0001388)1.83525079
121Aneurysm (HP:0002617)1.83435127
122Episodic fever (HP:0001954)1.83315055
123Hypercortisolism (HP:0001578)1.82937187
124Mitral valve prolapse (HP:0001634)1.81968079
125Orthostatic hypotension (HP:0001278)1.79775575
126Skin nodule (HP:0200036)1.79744359
127Hyperparathyroidism (HP:0000843)1.79145522
128Abnormality of the distal phalanges of the toes (HP:0010182)1.79016790
129Femoral bowing (HP:0002980)1.77650598
130Irregular vertebral endplates (HP:0003301)1.77577780
131Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76487804
132Distal upper limb amyotrophy (HP:0007149)1.76329426
133Upper limb amyotrophy (HP:0009129)1.76329426
134Prolonged neonatal jaundice (HP:0006579)1.75813801
135Abnormality of glutamine family amino acid metabolism (HP:0010902)1.74622841
136Right ventricular cardiomyopathy (HP:0011663)1.74598038
137Abnormality of skull ossification (HP:0002703)1.74431686
138Hypoplasia of the fovea (HP:0007750)1.73555073
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.73555073
140Aplasia/Hypoplasia affecting the retina (HP:0008061)1.73409768
141Glucose intolerance (HP:0000833)1.72848174
142Flared iliac wings (HP:0002869)1.72440043
143Abnormal foot bone ossification (HP:0010675)1.72141316
144Hypoalphalipoproteinemia (HP:0003233)1.71800747
145Distal lower limb muscle weakness (HP:0009053)1.71738281
146Bowel diverticulosis (HP:0005222)1.71731001
147Metaphyseal irregularity (HP:0003025)1.70784185
148Cerebral inclusion bodies (HP:0100314)1.70704646
149Flattened epiphyses (HP:0003071)1.69756179
150Thin bony cortex (HP:0002753)1.69438623
151Long toe (HP:0010511)1.69166943
152Arthropathy (HP:0003040)1.69092837
153Progressive neurologic deterioration (HP:0002344)1.66797748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PAK42.91381850
2FRK2.82734513
3PIM22.78807891
4DDR22.47943276
5TESK12.43107138
6MAP3K142.31520767
7MAP3K122.29672041
8NTRK12.29562704
9PDK22.29067497
10ERN12.19872980
11LIMK12.12807177
12TBK12.11066494
13TRPM72.10775047
14EPHA32.07882785
15EPHB12.03204461
16MAP3K31.99900205
17LATS21.99827875
18ERBB31.92879555
19NEK91.92094350
20GRK71.89136003
21ERBB41.83536723
22EIF2AK11.82115437
23MST41.78269781
24EIF2AK31.62658816
25MAP3K21.57706885
26TRIB31.56881695
27TGFBR21.56032018
28JAK31.53636386
29MAPK151.50838920
30PRKG21.49928707
31MATK1.46015908
32RIPK41.45621715
33TTN1.45021309
34NME21.43116433
35ARAF1.42792175
36NEK11.38631225
37CAMKK21.35388111
38TAOK21.28016735
39LRRK21.27133642
40PBK1.25966846
41PTK21.22023677
42TYK21.19592558
43PLK21.19496793
44BMPR1B1.15951433
45SIK31.15939526
46JAK11.14840568
47WEE11.12537357
48MYLK1.12272026
49MET1.11063858
50RIPK11.10295246
51FER1.10100350
52IKBKB1.08555616
53PTK61.08138778
54MOS1.07419457
55MAP2K11.06293723
56MAPKAPK31.05785903
57PIK3CG1.04696240
58MAP2K31.04443618
59BLK1.04103834
60IRAK41.02517141
61MST1R1.01868748
62MAPKAPK50.99963139
63CDC42BPA0.98660680
64PDGFRA0.98253024
65GRK50.98010354
66LATS10.95206088
67ZAP700.94960305
68FGFR30.93317307
69CLK10.92966662
70KIT0.92746442
71IKBKE0.91912069
72IRAK30.90614312
73TGFBR10.90313843
74FLT30.90236113
75SCYL20.89283643
76FGFR40.88123474
77EPHB20.88084818
78MAP2K20.86820056
79ROCK20.85134463
80GSK3A0.84848208
81CHUK0.83613887
82MARK30.82389599
83STK30.81282429
84BUB10.79729212
85TRIM280.79161151
86EPHA20.79068315
87ABL20.78288765
88MAP3K10.77823903
89ADRBK20.76373569
90CDK60.74057135
91FGR0.73982546
92KDR0.71094831
93MELK0.70530225
94RPS6KA40.70304877
95PTK2B0.68985058
96MAP3K110.68753203
97MAPKAPK20.68695868
98PAK20.67703483
99PRKCE0.66871377
100PAK60.66149125
101RET0.66076371
102BMPR20.65355296
103BMX0.64374346
104PLK30.62919561
105LMTK20.62712413
106TEC0.61892571
107STK38L0.60448863
108IRAK10.60218071
109STK380.58440917
110STK100.58188457
111CAMK1D0.58109311
112CSK0.57554841
113PAK10.57258709
114DAPK30.56946395
115KSR20.56755157
116STK240.56434357
117MAP3K80.55682101
118IGF1R0.55506621
119RPS6KA20.55337767
120TIE10.55272711
121PAK30.53033027
122SIK10.52659711
123JAK20.51989353
124ROCK10.51179042
125NLK0.51108053
126PRKCD0.50451216
127STK160.49913439
128PRKD30.49568095
129HIPK20.49307817
130PDGFRB0.49154764
131ILK0.48691555
132PRKD20.47621639
133ADRBK10.46921533
134ABL10.37873880
135BRSK10.34815506
136MUSK0.34813992
137FGFR10.34124195
138BCR0.33072146
139INSR0.32941666
140DMPK0.32905101
141CDK180.32570566
142EGFR0.29930332
143ACVR1B0.29893633
144PRKD10.28461134
145CDK140.27792135
146EIF2AK20.27630380
147CAMK2D0.27434023

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.59775029
2Phagosome_Homo sapiens_hsa041452.35135644
3Leishmaniasis_Homo sapiens_hsa051402.33168973
4Rheumatoid arthritis_Homo sapiens_hsa053232.29618288
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.27777030
6ECM-receptor interaction_Homo sapiens_hsa045122.08733319
7Malaria_Homo sapiens_hsa051442.05530595
8Protein export_Homo sapiens_hsa030602.02193419
9Pertussis_Homo sapiens_hsa051331.85312300
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.84364784
11Legionellosis_Homo sapiens_hsa051341.81784243
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79152300
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68137242
14Salmonella infection_Homo sapiens_hsa051321.60651484
15Osteoclast differentiation_Homo sapiens_hsa043801.59366075
16Glutathione metabolism_Homo sapiens_hsa004801.57815775
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57397160
18TNF signaling pathway_Homo sapiens_hsa046681.56930415
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.54165904
20Other glycan degradation_Homo sapiens_hsa005111.54041190
21Vibrio cholerae infection_Homo sapiens_hsa051101.48717910
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46261788
23Toxoplasmosis_Homo sapiens_hsa051451.46046426
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45943885
25Tuberculosis_Homo sapiens_hsa051521.45379994
26Shigellosis_Homo sapiens_hsa051311.45228611
27Amoebiasis_Homo sapiens_hsa051461.41020535
28Focal adhesion_Homo sapiens_hsa045101.39422404
29Fatty acid elongation_Homo sapiens_hsa000621.36414252
30Apoptosis_Homo sapiens_hsa042101.30963473
31Graft-versus-host disease_Homo sapiens_hsa053321.30224209
32Steroid biosynthesis_Homo sapiens_hsa001001.28861747
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27951971
34Pentose phosphate pathway_Homo sapiens_hsa000301.26222187
35Protein digestion and absorption_Homo sapiens_hsa049741.24588856
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23608272
37Allograft rejection_Homo sapiens_hsa053301.23465661
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23272476
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20044785
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18919853
41Sphingolipid metabolism_Homo sapiens_hsa006001.17789602
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15756358
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14690844
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.14175908
45Antigen processing and presentation_Homo sapiens_hsa046121.10405141
46Proteoglycans in cancer_Homo sapiens_hsa052051.09200599
47Hematopoietic cell lineage_Homo sapiens_hsa046401.07389930
48Staphylococcus aureus infection_Homo sapiens_hsa051501.07141271
49Viral myocarditis_Homo sapiens_hsa054161.07121683
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.06679883
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06590689
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04495930
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01933868
54Asthma_Homo sapiens_hsa053101.01863264
55Sulfur metabolism_Homo sapiens_hsa009201.01697737
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95852017
57Measles_Homo sapiens_hsa051620.89291818
58Influenza A_Homo sapiens_hsa051640.87079542
59Prolactin signaling pathway_Homo sapiens_hsa049170.86736275
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.86513491
61Folate biosynthesis_Homo sapiens_hsa007900.86191495
62Mineral absorption_Homo sapiens_hsa049780.83805393
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.81991293
64Vitamin B6 metabolism_Homo sapiens_hsa007500.81883283
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81404125
66Bladder cancer_Homo sapiens_hsa052190.81246117
67Type I diabetes mellitus_Homo sapiens_hsa049400.79008784
68Fructose and mannose metabolism_Homo sapiens_hsa000510.77601042
69African trypanosomiasis_Homo sapiens_hsa051430.77469764
70Thyroid cancer_Homo sapiens_hsa052160.77339893
71Adherens junction_Homo sapiens_hsa045200.75648822
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75050743
73Renin-angiotensin system_Homo sapiens_hsa046140.73737321
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71662688
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.71202744
76Autoimmune thyroid disease_Homo sapiens_hsa053200.70663467
77Chemokine signaling pathway_Homo sapiens_hsa040620.69593916
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69372521
79Prion diseases_Homo sapiens_hsa050200.69347913
80p53 signaling pathway_Homo sapiens_hsa041150.68940750
81PPAR signaling pathway_Homo sapiens_hsa033200.68934565
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.68918636
83Collecting duct acid secretion_Homo sapiens_hsa049660.68573104
84Complement and coagulation cascades_Homo sapiens_hsa046100.67587914
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66876927
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66831658
87Platelet activation_Homo sapiens_hsa046110.66310425
88Melanoma_Homo sapiens_hsa052180.63979082
89Hepatitis B_Homo sapiens_hsa051610.63020959
90Hepatitis C_Homo sapiens_hsa051600.62141841
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.61498765
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61470362
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59544306
94Carbon metabolism_Homo sapiens_hsa012000.59417070
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58825197
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.58174488
97Endocytosis_Homo sapiens_hsa041440.58131793
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56603087
99TGF-beta signaling pathway_Homo sapiens_hsa043500.56526996
100Chronic myeloid leukemia_Homo sapiens_hsa052200.56311897
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55158705
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.54198753
103Pancreatic cancer_Homo sapiens_hsa052120.54072028
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53210116
105Prostate cancer_Homo sapiens_hsa052150.52895765
106MicroRNAs in cancer_Homo sapiens_hsa052060.52000483
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51263228
108Caffeine metabolism_Homo sapiens_hsa002320.51001463
109Small cell lung cancer_Homo sapiens_hsa052220.50895405
110Pathways in cancer_Homo sapiens_hsa052000.50409980
111N-Glycan biosynthesis_Homo sapiens_hsa005100.49890146
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.48509089
113Galactose metabolism_Homo sapiens_hsa000520.46813265
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46518881
115HIF-1 signaling pathway_Homo sapiens_hsa040660.43576064
116B cell receptor signaling pathway_Homo sapiens_hsa046620.42264374
117Tyrosine metabolism_Homo sapiens_hsa003500.40289291
118Starch and sucrose metabolism_Homo sapiens_hsa005000.39896397
119Dilated cardiomyopathy_Homo sapiens_hsa054140.39771187
120Proteasome_Homo sapiens_hsa030500.39699231
121Rap1 signaling pathway_Homo sapiens_hsa040150.38722295
122Insulin resistance_Homo sapiens_hsa049310.36347345
123Hippo signaling pathway_Homo sapiens_hsa043900.35565496
124Biosynthesis of amino acids_Homo sapiens_hsa012300.35140445
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34667888
126Pyruvate metabolism_Homo sapiens_hsa006200.33947107

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