ANXA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.70435708
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70435708
3Golgi transport vesicle coating (GO:0048200)4.23701068
4COPI coating of Golgi vesicle (GO:0048205)4.23701068
5antigen processing and presentation of endogenous antigen (GO:0019883)4.09124096
6positive thymic T cell selection (GO:0045059)4.07333000
7positive regulation of gamma-delta T cell activation (GO:0046645)3.97245715
8negative T cell selection (GO:0043383)3.78170925
9negative thymic T cell selection (GO:0045060)3.66332893
10negative regulation of fatty acid transport (GO:2000192)3.60652638
11regulation of gamma-delta T cell differentiation (GO:0045586)3.59126143
12protein localization to endosome (GO:0036010)3.51845461
13protein heterotrimerization (GO:0070208)3.48258648
14plasma membrane repair (GO:0001778)3.46792704
15low-density lipoprotein particle clearance (GO:0034383)3.42041820
16valine metabolic process (GO:0006573)3.37746838
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.37700638
18negative regulation of cell killing (GO:0031342)3.37700638
19thymic T cell selection (GO:0045061)3.35840786
20regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.28171074
21regulation of tight junction assembly (GO:2000810)3.27640034
22positive regulation of fatty acid beta-oxidation (GO:0032000)3.23334914
23positive T cell selection (GO:0043368)3.21381725
24endodermal cell differentiation (GO:0035987)3.19956098
25regulation of fatty acid beta-oxidation (GO:0031998)3.12927998
26membrane raft organization (GO:0031579)3.12185595
27vascular endothelial growth factor signaling pathway (GO:0038084)3.10839848
28apoptotic cell clearance (GO:0043277)3.09332606
29regulation of gamma-delta T cell activation (GO:0046643)3.09263023
30collagen fibril organization (GO:0030199)3.08971103
31regulation of B cell receptor signaling pathway (GO:0050855)3.07137812
32heterotypic cell-cell adhesion (GO:0034113)3.06453782
33B cell receptor signaling pathway (GO:0050853)3.05044272
34negative regulation of erythrocyte differentiation (GO:0045647)3.04787676
35positive regulation of histone deacetylation (GO:0031065)3.04473453
36pinocytosis (GO:0006907)3.01496794
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98994459
38muscle filament sliding (GO:0030049)2.98220607
39actin-myosin filament sliding (GO:0033275)2.98220607
40positive regulation of glycogen biosynthetic process (GO:0045725)2.96968330
41regulation of macrophage cytokine production (GO:0010935)2.96903280
42mannose metabolic process (GO:0006013)2.95713354
43positive regulation of fatty acid oxidation (GO:0046321)2.92120226
44cortical actin cytoskeleton organization (GO:0030866)2.91947459
45growth hormone receptor signaling pathway (GO:0060396)2.91615630
46regulation of isotype switching to IgG isotypes (GO:0048302)2.90493890
47response to interleukin-15 (GO:0070672)2.89892065
48regulation of fatty acid oxidation (GO:0046320)2.89083726
49cell adhesion mediated by integrin (GO:0033627)2.88248109
50positive regulation of macrophage cytokine production (GO:0060907)2.88007846
51oxaloacetate metabolic process (GO:0006107)2.87297354
52positive regulation of myotube differentiation (GO:0010831)2.85975997
53antigen processing and presentation via MHC class Ib (GO:0002475)2.85450097
54tricarboxylic acid metabolic process (GO:0072350)2.82626141
55sarcomere organization (GO:0045214)2.81772078
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80948668
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.80948668
58modulation by symbiont of host immune response (GO:0052553)2.80948668
59positive regulation by symbiont of host defense response (GO:0052509)2.80948668
60modulation by symbiont of host defense response (GO:0052031)2.80948668
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80948668
62fatty acid transmembrane transport (GO:1902001)2.80890094
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80046263
64negative regulation of cell size (GO:0045792)2.79370475
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.79055464
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.78656529
67stress fiber assembly (GO:0043149)2.78584527
68focal adhesion assembly (GO:0048041)2.78179463
69cell-substrate adherens junction assembly (GO:0007045)2.78179463
70basement membrane organization (GO:0071711)2.77961718
71regulation of response to interferon-gamma (GO:0060330)2.77750589
72response to laminar fluid shear stress (GO:0034616)2.76683277
73regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.74821539
74detection of bacterium (GO:0016045)2.74579369
75carnitine shuttle (GO:0006853)2.72779425
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71924101
77T cell selection (GO:0045058)2.69808653
78adherens junction assembly (GO:0034333)2.69698106
79detection of other organism (GO:0098543)2.69304886
80regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68871528
81retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68764217
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64658275
83negative regulation of phagocytosis (GO:0050765)2.63738606
84cell-substrate junction assembly (GO:0007044)2.63106166
85fibril organization (GO:0097435)2.60864871
86positive regulation of endothelial cell apoptotic process (GO:2000353)2.59218277
87regulation of T cell tolerance induction (GO:0002664)2.57920954
88T cell migration (GO:0072678)2.57878456
89protein retention in ER lumen (GO:0006621)2.55576765
90cellular response to type I interferon (GO:0071357)2.55522027
91type I interferon signaling pathway (GO:0060337)2.55522027
92cardiac myofibril assembly (GO:0055003)2.55159181
93negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.55052453
94JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54969723
95cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.54773193
96regulation of defense response to virus by virus (GO:0050690)2.54225789
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54116084
98response to type I interferon (GO:0034340)2.52469652
99response to muramyl dipeptide (GO:0032495)2.52444515
100regulation of extracellular matrix disassembly (GO:0010715)2.51884929
101interferon-gamma production (GO:0032609)2.51596040
102activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51520783
103endothelial tube morphogenesis (GO:0061154)2.51454516
104morphogenesis of an endothelium (GO:0003159)2.51454516
105skin morphogenesis (GO:0043589)2.50986081
106NIK/NF-kappaB signaling (GO:0038061)2.49901116
107insulin-like growth factor receptor signaling pathway (GO:0048009)2.48752764
108tricarboxylic acid cycle (GO:0006099)2.48655944
109positive regulation of lamellipodium assembly (GO:0010592)2.48450527
110regulation of sequestering of triglyceride (GO:0010889)2.48448881
111extracellular fibril organization (GO:0043206)2.48016275
112actin-mediated cell contraction (GO:0070252)2.46914537
113cortical cytoskeleton organization (GO:0030865)2.46895318
114negative regulation of protein autophosphorylation (GO:0031953)2.46568374
115T cell costimulation (GO:0031295)2.46089842
116cell migration involved in heart development (GO:0060973)2.45689641
117positive regulation of blood vessel endothelial cell migration (GO:0043536)2.45547502
1182-oxoglutarate metabolic process (GO:0006103)2.44963239
119hypotonic response (GO:0006971)2.44477910
120barbed-end actin filament capping (GO:0051016)2.44114632
121cellular response to growth hormone stimulus (GO:0071378)2.43754988
122positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43693187
123positive regulation of glycogen metabolic process (GO:0070875)2.42880833
124regulation of cholesterol storage (GO:0010885)2.42541612
125regulation of natural killer cell mediated immunity (GO:0002715)2.42169470
126regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.42169470
127regulation of early endosome to late endosome transport (GO:2000641)2.41409879
128positive regulation of extracellular matrix organization (GO:1903055)2.41330408
129endothelial cell chemotaxis (GO:0035767)2.41174004
130epithelial cell-cell adhesion (GO:0090136)2.41043736
131positive regulation of natural killer cell differentiation (GO:0032825)2.40352245
132leukocyte aggregation (GO:0070486)2.40328209
133lymphocyte costimulation (GO:0031294)2.39901026
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.39303537
135Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38332701
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38021996
137platelet aggregation (GO:0070527)2.37760498
138positive regulation of nuclease activity (GO:0032075)2.37668918
139sequestering of actin monomers (GO:0042989)2.35951058
140positive regulation of receptor recycling (GO:0001921)2.35269741
141detection of external biotic stimulus (GO:0098581)2.35121498
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.35042086
143positive regulation of protein dephosphorylation (GO:0035307)2.34907700
144alpha-linolenic acid metabolic process (GO:0036109)2.33646589
145venous blood vessel morphogenesis (GO:0048845)2.33589085
146positive regulation of protein deacetylation (GO:0090312)2.33229829
147modulation by symbiont of host cellular process (GO:0044068)2.32972722
148extracellular matrix assembly (GO:0085029)2.30782063
149cellular response to interleukin-15 (GO:0071350)2.29320536
150B cell homeostasis (GO:0001782)2.27701343
151regulation of ARF protein signal transduction (GO:0032012)2.27026664
152embryonic process involved in female pregnancy (GO:0060136)2.25582012
153myeloid dendritic cell differentiation (GO:0043011)2.24393680
154positive regulation of fibroblast migration (GO:0010763)2.23116765
155regulation of lipid kinase activity (GO:0043550)2.22564667
156adhesion of symbiont to host (GO:0044406)2.22554583
157positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.22037772
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.19233266
159protein targeting to plasma membrane (GO:0072661)2.19056929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84869631
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97885499
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.69779566
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.63874141
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.34259241
6CLOCK_20551151_ChIP-Seq_293T_Human3.23674595
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84507235
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.82915879
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.64681857
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63336482
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.57432195
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.37965678
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21893680
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.18113372
15MYC_22102868_ChIP-Seq_BL_Human2.16473093
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14919729
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08209255
18RUNX_20019798_ChIP-Seq_JUKART_Human2.08165498
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.99025603
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97001795
21MAF_26560356_Chip-Seq_TH1_Human1.96494936
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91306913
23* RXR_22158963_ChIP-Seq_LIVER_Mouse1.83418564
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79444152
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76698090
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72073922
27UTX_26944678_Chip-Seq_JUKART_Human1.71748232
28* MYB_26560356_Chip-Seq_TH2_Human1.71604004
29KDM2B_26808549_Chip-Seq_DND41_Human1.71576044
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.67072219
31VDR_21846776_ChIP-Seq_THP-1_Human1.65695986
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.63145528
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61334810
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61153391
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.60542910
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60129098
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59727575
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59471886
39TBX20_22328084_ChIP-Seq_HEART_Mouse1.59412916
40TBX20_22080862_ChIP-Seq_HEART_Mouse1.59412916
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59144437
42* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58386082
43GATA1_22025678_ChIP-Seq_K562_Human1.55026017
44TCF7_22412390_ChIP-Seq_EML_Mouse1.54600084
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53151815
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52182965
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51565045
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50475709
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.50382647
50* LXR_22292898_ChIP-Seq_THP-1_Human1.48183931
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46507839
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45469235
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44847409
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43548231
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.43381138
56KDM2B_26808549_Chip-Seq_K562_Human1.41760480
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41336017
58RACK7_27058665_Chip-Seq_MCF-7_Human1.39238481
59MYB_26560356_Chip-Seq_TH1_Human1.38801307
60* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37801643
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32977950
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32356548
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32020582
64SPI1_23127762_ChIP-Seq_K562_Human1.31994545
65* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31329121
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.30356289
67ATF3_27146783_Chip-Seq_COLON_Human1.29759664
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29089350
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28337054
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27697132
71VDR_24763502_ChIP-Seq_THP-1_Human1.26374334
72SMC1_22415368_ChIP-Seq_MEFs_Mouse1.25759266
73* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24332990
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.23667403
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23230344
76* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22940464
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.21277278
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20757443
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20143926
80GATA3_27048872_Chip-Seq_THYMUS_Human1.18405002
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.17566297
82CJUN_26792858_Chip-Seq_BT549_Human1.16586837
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16325924
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14865819
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14617278
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13596087
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.13009849
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12959187
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12368957
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.12152212
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11473085
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11369916
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10046570
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09808768
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09808768
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09555266
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09173673
98TP53_22127205_ChIP-Seq_IMR90_Human1.08530972
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07695779
100* MAF_26560356_Chip-Seq_TH2_Human1.07241867
101BRD4_25478319_ChIP-Seq_HGPS_Human1.07078032
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06502703
103* RUNX1_22412390_ChIP-Seq_EML_Mouse1.06289653
104IRF8_27001747_Chip-Seq_BMDM_Mouse1.06209050
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05834342
106JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05614765
107* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03219590
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03212443
109NCOR1_26117541_ChIP-Seq_K562_Human1.03212264
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02501048
111KDM2B_26808549_Chip-Seq_JURKAT_Human1.02441638
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02409493
113SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00758807
114ZNF263_19887448_ChIP-Seq_K562_Human1.00641197
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99731195
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99129626
117WT1_19549856_ChIP-ChIP_CCG9911_Human0.98332419
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98044817
119SPI1_23547873_ChIP-Seq_NB4_Human0.97742509
120* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97699992
121EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97154339
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.97110200
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95521199
124* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94238246
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.94197687
126GATA1_19941826_ChIP-Seq_K562_Human0.93784898
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92732333
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91276635
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90978048
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90790216
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89989487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.01025668
2MP0003705_abnormal_hypodermis_morpholog3.48973270
3MP0005275_abnormal_skin_tensile3.00677997
4MP0003279_aneurysm2.70734691
5MP0003566_abnormal_cell_adhesion2.48982575
6MP0003303_peritoneal_inflammation2.21241549
7MP0002837_dystrophic_cardiac_calcinosis2.19539745
8MP0003300_gastrointestinal_ulcer2.10665427
9MP0005670_abnormal_white_adipose2.09396937
10MP0004272_abnormal_basement_membrane2.09220793
11MP0004084_abnormal_cardiac_muscle2.08103614
12MP0004130_abnormal_muscle_cell2.03940177
13MP0005503_abnormal_tendon_morphology1.96660677
14MP0005257_abnormal_intraocular_pressure1.94429201
15MP0001958_emphysema1.87935233
16MP0003045_fibrosis1.86288004
17MP0002166_altered_tumor_susceptibility1.83955555
18MP0000751_myopathy1.79351746
19MP0010352_gastrointestinal_tract_polyps1.77977302
20MP0005023_abnormal_wound_healing1.77891395
21MP0000013_abnormal_adipose_tissue1.76617609
22MP0005451_abnormal_body_composition1.75266759
23MP0000749_muscle_degeneration1.71860727
24MP0001348_abnormal_lacrimal_gland1.69945999
25MP0003763_abnormal_thymus_physiology1.69820098
26MP0005666_abnormal_adipose_tissue1.64579458
27MP0000685_abnormal_immune_system1.59795766
28MP0006054_spinal_hemorrhage1.54950913
29MP0004185_abnormal_adipocyte_glucose1.52761942
30MP0003091_abnormal_cell_migration1.51831399
31MP0004087_abnormal_muscle_fiber1.51560653
32MP0001542_abnormal_bone_strength1.48635096
33MP0000858_altered_metastatic_potential1.46496187
34MP0005375_adipose_tissue_phenotype1.42800889
35MP0000750_abnormal_muscle_regeneration1.42511104
36MP0009384_cardiac_valve_regurgitation1.42143386
37MP0002419_abnormal_innate_immunity1.40639396
38MP0002933_joint_inflammation1.40324107
39MP0005623_abnormal_meninges_morphology1.38214947
40MP0005671_abnormal_response_to1.37161226
41MP0002006_tumorigenesis1.34228125
42MP0000003_abnormal_adipose_tissue1.32872395
43MP0000733_abnormal_muscle_development1.32513180
44MP0005330_cardiomyopathy1.28243947
45MP0004036_abnormal_muscle_relaxation1.27374421
46MP0008260_abnormal_autophagy1.25653251
47MP0010630_abnormal_cardiac_muscle1.23114121
48MP0002060_abnormal_skin_morphology1.19965146
49MP0001835_abnormal_antigen_presentation1.18931775
50MP0003172_abnormal_lysosome_physiology1.18633545
51MP0000767_abnormal_smooth_muscle1.17985900
52MP0001544_abnormal_cardiovascular_syste1.16717928
53MP0005385_cardiovascular_system_phenoty1.16717928
54MP0000759_abnormal_skeletal_muscle1.15719866
55MP0002877_abnormal_melanocyte_morpholog1.15644142
56MP0009840_abnormal_foam_cell1.14602141
57MP0004510_myositis1.14045514
58MP0002168_other_aberrant_phenotype1.12946165
59MP0010368_abnormal_lymphatic_system1.11453439
60MP0002269_muscular_atrophy1.11377142
61MP0003448_altered_tumor_morphology1.10120042
62MP0003436_decreased_susceptibility_to1.06779666
63MP0001533_abnormal_skeleton_physiology1.05561652
64MP0004947_skin_inflammation1.05394810
65MP0001849_ear_inflammation1.04736337
66MP0006138_congestive_heart_failure1.04124766
67MP0003183_abnormal_peptide_metabolism1.03589742
68MP0001243_abnormal_dermal_layer1.03144759
69MP0003828_pulmonary_edema1.02840372
70MP0000343_altered_response_to1.02070325
71MP0003191_abnormal_cellular_cholesterol1.01810062
72MP0008775_abnormal_heart_ventricle1.01745908
73MP0000747_muscle_weakness1.01708160
74MP0003329_amyloid_beta_deposits0.98304883
75MP0000716_abnormal_immune_system0.98248623
76* MP0002972_abnormal_cardiac_muscle0.97713917
77MP0005387_immune_system_phenotype0.96840807
78MP0001790_abnormal_immune_system0.96840807
79MP0010234_abnormal_vibrissa_follicle0.96787200
80MP0002405_respiratory_system_inflammati0.95753364
81MP0003075_altered_response_to0.95131428
82MP0002998_abnormal_bone_remodeling0.93979514
83MP0001851_eye_inflammation0.93710160
84MP0000604_amyloidosis0.93096032
85MP0009333_abnormal_splenocyte_physiolog0.91377766
86MP0009785_altered_susceptibility_to0.91025448
87MP0002128_abnormal_blood_circulation0.90869990
88MP0005620_abnormal_muscle_contractility0.89570106
89MP0005058_abnormal_lysosome_morphology0.88251937
90MP0003724_increased_susceptibility_to0.87722609
91MP0004858_abnormal_nervous_system0.87462974
92MP0001800_abnormal_humoral_immune0.86247784
93MP0009115_abnormal_fat_cell0.86085502
94MP0010329_abnormal_lipoprotein_level0.85771515
95MP0006082_CNS_inflammation0.85540568
96MP0004233_abnormal_muscle_weight0.85475741
97MP0002420_abnormal_adaptive_immunity0.85396048
98MP0005165_increased_susceptibility_to0.84529096
99MP0001819_abnormal_immune_cell0.84314373
100MP0002971_abnormal_brown_adipose0.84240569
101MP0002106_abnormal_muscle_physiology0.84016231
102MP0002148_abnormal_hypersensitivity_rea0.82585551
103MP0001845_abnormal_inflammatory_respons0.82357277
104MP0003795_abnormal_bone_structure0.81940134
105MP0000609_abnormal_liver_physiology0.81915243
106MP0005000_abnormal_immune_tolerance0.80723894
107MP0005076_abnormal_cell_differentiation0.80710257
108MP0002896_abnormal_bone_mineralization0.80672245
109MP0002429_abnormal_blood_cell0.79758668
110MP0000249_abnormal_blood_vessel0.79271888
111MP0001661_extended_life_span0.79248442
112MP0002295_abnormal_pulmonary_circulatio0.78817663
113MP0003959_abnormal_lean_body0.78009642
114MP0001915_intracranial_hemorrhage0.77802019
115MP0002452_abnormal_antigen_presenting0.77801816
116MP0005464_abnormal_platelet_physiology0.77634725
117MP0005508_abnormal_skeleton_morphology0.77634223
118MP0005390_skeleton_phenotype0.76872256
119MP0005025_abnormal_response_to0.74978720
120MP0010155_abnormal_intestine_physiology0.73937039
121MP0008961_abnormal_basal_metabolism0.73292810
122MP0002970_abnormal_white_adipose0.72646247
123MP0002108_abnormal_muscle_morphology0.72556920
124MP0002398_abnormal_bone_marrow0.72484433
125MP0002723_abnormal_immune_serum0.72476871

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.19727403
2Premature rupture of membranes (HP:0001788)4.12298790
3Aortic dissection (HP:0002647)3.99468763
4Cerebral aneurysm (HP:0004944)3.98518918
5Type 1 muscle fiber predominance (HP:0003803)3.92189078
6Aortic aneurysm (HP:0004942)3.86503780
7Ankle contracture (HP:0006466)3.70995403
8Increased connective tissue (HP:0009025)3.63746094
9Broad metatarsal (HP:0001783)3.28288739
10Dilatation of the ascending aorta (HP:0005111)3.25814341
11Increased variability in muscle fiber diameter (HP:0003557)2.83806969
12Gastrointestinal stroma tumor (HP:0100723)2.80951562
13Cervical subluxation (HP:0003308)2.80906387
14Shallow orbits (HP:0000586)2.80134984
15Abnormality of skeletal muscle fiber size (HP:0012084)2.76211910
16Hyporeflexia of lower limbs (HP:0002600)2.73550821
17Spinal rigidity (HP:0003306)2.72709813
18Mitral valve prolapse (HP:0001634)2.72367178
19Emphysema (HP:0002097)2.71219168
20Atrophic scars (HP:0001075)2.62429481
21Cellulitis (HP:0100658)2.61426233
22Aneurysm (HP:0002617)2.60065173
23Striae distensae (HP:0001065)2.57282076
24Peritonitis (HP:0002586)2.56002035
25Eczematoid dermatitis (HP:0000976)2.55777578
26Vertebral compression fractures (HP:0002953)2.53202917
27Increased density of long bones (HP:0006392)2.48586396
28Long toe (HP:0010511)2.48509003
29Myoglobinuria (HP:0002913)2.46689255
30Mildly elevated creatine phosphokinase (HP:0008180)2.46302490
31Difficulty climbing stairs (HP:0003551)2.40333683
32Right ventricular cardiomyopathy (HP:0011663)2.39052006
33Genu recurvatum (HP:0002816)2.35501721
34Bladder diverticulum (HP:0000015)2.31960265
35T lymphocytopenia (HP:0005403)2.27574757
36Scapular winging (HP:0003691)2.26671640
37Difficulty running (HP:0009046)2.26266829
38Distal lower limb muscle weakness (HP:0009053)2.25071911
39Camptodactyly of toe (HP:0001836)2.24789919
40Lipoatrophy (HP:0100578)2.24250700
41Fragile skin (HP:0001030)2.24011669
42Muscle fiber splitting (HP:0003555)2.23881462
43Frequent falls (HP:0002359)2.23028197
44Blue sclerae (HP:0000592)2.21520194
45Mitral regurgitation (HP:0001653)2.21333374
46Osteolytic defects of the hand bones (HP:0009699)2.20931088
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.20931088
48Abnormality of T cell number (HP:0011839)2.18600270
49Distal lower limb amyotrophy (HP:0008944)2.18320756
50Distal arthrogryposis (HP:0005684)2.15899581
51Slender build (HP:0001533)2.15826959
52Ectopia lentis (HP:0001083)2.15301238
53Asymmetric septal hypertrophy (HP:0001670)2.14620154
54Exercise-induced muscle cramps (HP:0003710)2.13117450
55Biconcave vertebral bodies (HP:0004586)2.12579406
56Exercise-induced myalgia (HP:0003738)2.10771952
57Wrist flexion contracture (HP:0001239)2.07554216
58Soft skin (HP:0000977)2.06952844
59Spontaneous hematomas (HP:0007420)2.06073216
60Hyperacusis (HP:0010780)2.05517647
61Abnormality of the nasal mucosa (HP:0000433)2.05339393
62Wormian bones (HP:0002645)2.04100051
63Nemaline bodies (HP:0003798)2.00098480
64Upper limb amyotrophy (HP:0009129)1.99439359
65Distal upper limb amyotrophy (HP:0007149)1.99439359
66Sudden death (HP:0001699)1.99196222
67Ventricular tachycardia (HP:0004756)1.96750577
68Achilles tendon contracture (HP:0001771)1.96634057
69Facial diplegia (HP:0001349)1.96601416
70Thin bony cortex (HP:0002753)1.95545012
71Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95056372
72Abnormality of macrophages (HP:0004311)1.95012344
73Dysostosis multiplex (HP:0000943)1.94783482
74Follicular hyperkeratosis (HP:0007502)1.93734557
75Persistence of primary teeth (HP:0006335)1.93087638
76Nasal polyposis (HP:0100582)1.92169369
77Rhabdomyolysis (HP:0003201)1.91970248
78Colitis (HP:0002583)1.91125173
79Ulnar deviation of the wrist (HP:0003049)1.90433731
80Joint contractures involving the joints of the feet (HP:0100492)1.89260869
81Flexion contracture of toe (HP:0005830)1.89260869
82Spondylolisthesis (HP:0003302)1.86276415
83Joint laxity (HP:0001388)1.85935416
84Hyperextensible skin (HP:0000974)1.85666899
85Round ear (HP:0100830)1.85614506
86Abnormality of dentin (HP:0010299)1.85592593
87Abnormality of the peritoneum (HP:0002585)1.85359893
88Mesomelia (HP:0003027)1.85359704
89Muscle fiber inclusion bodies (HP:0100299)1.85142560
90Myocardial infarction (HP:0001658)1.84830609
91Neonatal short-limb short stature (HP:0008921)1.84251242
92Elbow flexion contracture (HP:0002987)1.83816682
93Hematochezia (HP:0002573)1.83779120
94EMG: myopathic abnormalities (HP:0003458)1.83630384
95Vascular tortuosity (HP:0004948)1.83090724
96Bowel diverticulosis (HP:0005222)1.82820813
97Generalized amyotrophy (HP:0003700)1.82113797
98Increased mean platelet volume (HP:0011877)1.81523653
99Joint stiffness (HP:0001387)1.80682908
100Cupped ribs (HP:0000887)1.80336297
101Radial bowing (HP:0002986)1.78390761
102Subacute progressive viral hepatitis (HP:0006572)1.77952974
103Agammaglobulinemia (HP:0004432)1.77146912
104Abnormality of the calcaneus (HP:0008364)1.76802509
105Syringomyelia (HP:0003396)1.76287141
106Spinal cord lesions (HP:0100561)1.76287141
107Myotonia (HP:0002486)1.75725548
108Acanthosis nigricans (HP:0000956)1.75126434
109Abnormality of the calf musculature (HP:0001430)1.74830356
110Abnormality of the Achilles tendon (HP:0005109)1.74699523
111Aortic regurgitation (HP:0001659)1.73860515
112Abnormal platelet volume (HP:0011876)1.73037850
113Arterial tortuosity (HP:0005116)1.72829166
114Hand muscle atrophy (HP:0009130)1.72133797
115Gastrointestinal infarctions (HP:0005244)1.71966271
116Disproportionate tall stature (HP:0001519)1.71288927
117Abnormality of the left ventricular outflow tract (HP:0011103)1.70855937
118Subaortic stenosis (HP:0001682)1.70855937
119Ulnar bowing (HP:0003031)1.70241529
120Mitral stenosis (HP:0001718)1.69064799
121Meningitis (HP:0001287)1.68841809
122Bicuspid aortic valve (HP:0001647)1.68223295
123Elevated erythrocyte sedimentation rate (HP:0003565)1.68165863
124Lymphangioma (HP:0100764)1.68095837
125Enlarged penis (HP:0000040)1.67879923
126Restrictive lung disease (HP:0002091)1.67467061
127Urinary glycosaminoglycan excretion (HP:0003541)1.67035086
128Mucopolysacchariduria (HP:0008155)1.67035086
129Hypercortisolism (HP:0001578)1.66821391
130Ovoid vertebral bodies (HP:0003300)1.65273222
131Overgrowth (HP:0001548)1.64317550
132Knee flexion contracture (HP:0006380)1.64164223
133Myositis (HP:0100614)1.64123123
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.63976514
135Broad face (HP:0000283)1.63647238
136Nonimmune hydrops fetalis (HP:0001790)1.63585980
137Oligomenorrhea (HP:0000876)1.63236042
138Vasculitis (HP:0002633)1.63191530
139Lumbar hyperlordosis (HP:0002938)1.63183933
140Lower limb amyotrophy (HP:0007210)1.62609070
141Abnormal delivery (HP:0001787)1.61477383
142Recurrent bronchitis (HP:0002837)1.61164670
143IgA deficiency (HP:0002720)1.58663432
144Lymphopenia (HP:0001888)1.57923609
145Coxa vara (HP:0002812)1.56388968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.05076478
2PRPF4B4.12265930
3TTN3.64490099
4PKN23.50718609
5FGFR42.64450790
6SIK12.36802207
7MAP4K12.32458246
8RIPK42.23801987
9ERN12.23003013
10MAP3K132.06338188
11PDGFRA2.02151996
12LRRK21.96896798
13RIPK11.96535656
14JAK31.91643746
15SMG11.91530113
16MYLK1.88830192
17JAK11.88636441
18EEF2K1.78890441
19ZAP701.77854351
20MAP3K141.75486865
21FLT31.73247037
22TXK1.71173597
23ITK1.67343792
24STK101.65745553
25FGFR31.62157351
26LMTK21.58608376
27ICK1.55353031
28EPHA31.55035518
29TYK21.53000436
30PTK61.41278524
31MAP3K101.37416502
32NEK91.36393401
33ILK1.34396148
34TAOK21.32299917
35TBK11.30333541
36TGFBR21.27614460
37MAP2K31.25217127
38DDR21.24048567
39MAPKAPK31.23729419
40KDR1.22646033
41PTK21.18848672
42BLK1.18076001
43CDK121.17952996
44ARAF1.16391559
45PRKCH1.13484724
46TESK11.12351503
47DMPK1.07405028
48TRPM71.07302609
49EPHB11.06789620
50CAMK1D1.05956313
51PRKD21.03932412
52CSK1.02830910
53MAPK121.01876430
54OBSCN1.01818190
55RET1.00469754
56BCKDK1.00120685
57MAPK70.96466388
58CAMKK10.94165572
59PDGFRB0.92451522
60FES0.91491047
61LIMK10.91372281
62PIK3CG0.89396697
63SCYL20.87758264
64PAK20.86047820
65SYK0.84685466
66PDPK10.83986431
67MAP3K110.83651891
68RPS6KA40.81565224
69STK240.77873397
70MAP3K10.77702497
71IRAK40.77598419
72MARK20.77549376
73FGFR10.76741027
74KIT0.75421359
75PAK60.73744328
76FER0.73640595
77MAP3K70.73177992
78PIK3CA0.72006407
79STK380.71276742
80TESK20.69681408
81IKBKE0.69394717
82PDK30.68326336
83PDK40.68326336
84PAK40.68095516
85LATS20.66359579
86LCK0.65563657
87JAK20.62607523
88NLK0.62134730
89MAP2K10.61952311
90MARK30.61476539
91ROCK10.60983527
92LATS10.59739132
93MTOR0.58260706
94PAK30.57953701
95MAP3K30.57617043
96TGFBR10.57518749
97PRKG20.56786118
98IRAK30.56571008
99MOS0.56455603
100HCK0.55907300
101PTK2B0.55312286
102MAPK40.54745876
103DYRK1B0.53769856
104CDC42BPA0.53613556
105KSR20.53457124
106MAP3K60.52041216
107CSF1R0.51753722
108BMX0.51048386
109CDK60.50986201
110SIK20.50598838
111RPS6KC10.50324695
112RPS6KL10.50324695
113DAPK30.48329558
114PRKD10.48065010
115HIPK20.47439149
116NEK10.47228747
117GRK60.47148413
118IGF1R0.45590744
119MELK0.45167222
120INSR0.43285163
121CAMK1G0.43174127
122NTRK10.42047370
123LYN0.41057990
124BTK0.40219097
125PDK10.39208558
126RPS6KB20.38917814
127MAP3K80.38858578
128MAPK110.37112164
129ROCK20.33972319
130TEC0.32640475
131SRC0.32518434
132RPS6KA20.31239802
133CDK40.29698752

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05775645
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13697940
3Viral myocarditis_Homo sapiens_hsa054162.12424988
4Focal adhesion_Homo sapiens_hsa045102.01692476
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.95429915
6Fatty acid degradation_Homo sapiens_hsa000711.89815175
7ECM-receptor interaction_Homo sapiens_hsa045121.87410245
8Other glycan degradation_Homo sapiens_hsa005111.81419454
9Allograft rejection_Homo sapiens_hsa053301.78608086
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74653969
11Primary immunodeficiency_Homo sapiens_hsa053401.74507177
12Dilated cardiomyopathy_Homo sapiens_hsa054141.71735520
13Antigen processing and presentation_Homo sapiens_hsa046121.64297022
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.59455681
15Fatty acid metabolism_Homo sapiens_hsa012121.57173523
16PPAR signaling pathway_Homo sapiens_hsa033201.57130055
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51539652
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50043585
19T cell receptor signaling pathway_Homo sapiens_hsa046601.47432409
20Insulin resistance_Homo sapiens_hsa049311.46791630
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44471269
22Propanoate metabolism_Homo sapiens_hsa006401.43570004
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42020999
24Toxoplasmosis_Homo sapiens_hsa051451.40038407
25Adherens junction_Homo sapiens_hsa045201.37406657
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.35677021
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32883554
28Proteoglycans in cancer_Homo sapiens_hsa052051.32716963
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.30992745
30Amoebiasis_Homo sapiens_hsa051461.27122909
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.25239431
32Leishmaniasis_Homo sapiens_hsa051401.23589571
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19941528
34Chronic myeloid leukemia_Homo sapiens_hsa052201.19854696
35Graft-versus-host disease_Homo sapiens_hsa053321.18338279
36Measles_Homo sapiens_hsa051621.16426278
37Carbon metabolism_Homo sapiens_hsa012001.15954059
38Shigellosis_Homo sapiens_hsa051311.15537285
39Prion diseases_Homo sapiens_hsa050201.14864239
40Platelet activation_Homo sapiens_hsa046111.11274745
41Pancreatic cancer_Homo sapiens_hsa052121.10488707
42Insulin signaling pathway_Homo sapiens_hsa049101.09996311
43Caffeine metabolism_Homo sapiens_hsa002321.09991744
44Osteoclast differentiation_Homo sapiens_hsa043801.08803679
45Influenza A_Homo sapiens_hsa051641.06211289
46Small cell lung cancer_Homo sapiens_hsa052221.05976153
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05963471
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.04762123
49Tuberculosis_Homo sapiens_hsa051521.04205490
50Type I diabetes mellitus_Homo sapiens_hsa049401.02517507
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01412419
52Renal cell carcinoma_Homo sapiens_hsa052111.00367017
53Glioma_Homo sapiens_hsa052140.97849493
54Acute myeloid leukemia_Homo sapiens_hsa052210.95835488
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95484457
56Staphylococcus aureus infection_Homo sapiens_hsa051500.93626657
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92273471
58Protein digestion and absorption_Homo sapiens_hsa049740.92233039
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.92024595
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91381919
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.90994876
62Pyruvate metabolism_Homo sapiens_hsa006200.90596186
63GnRH signaling pathway_Homo sapiens_hsa049120.89073165
64Malaria_Homo sapiens_hsa051440.88804435
65Viral carcinogenesis_Homo sapiens_hsa052030.88126374
66AMPK signaling pathway_Homo sapiens_hsa041520.87967768
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87316367
68Fatty acid biosynthesis_Homo sapiens_hsa000610.87192596
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86784580
70Pentose phosphate pathway_Homo sapiens_hsa000300.86497282
71Chemokine signaling pathway_Homo sapiens_hsa040620.86356045
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.86238194
73Asthma_Homo sapiens_hsa053100.85090661
74VEGF signaling pathway_Homo sapiens_hsa043700.84860214
75Glucagon signaling pathway_Homo sapiens_hsa049220.83518675
76Apoptosis_Homo sapiens_hsa042100.82611065
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82374795
78mTOR signaling pathway_Homo sapiens_hsa041500.81973871
79Phagosome_Homo sapiens_hsa041450.81769290
80Systemic lupus erythematosus_Homo sapiens_hsa053220.81721248
81Thyroid cancer_Homo sapiens_hsa052160.81521513
82HIF-1 signaling pathway_Homo sapiens_hsa040660.78482508
83Herpes simplex infection_Homo sapiens_hsa051680.77291419
84Hepatitis B_Homo sapiens_hsa051610.76909728
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76618452
86B cell receptor signaling pathway_Homo sapiens_hsa046620.72330490
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.72022466
88TNF signaling pathway_Homo sapiens_hsa046680.70805331
89Long-term potentiation_Homo sapiens_hsa047200.70463645
90Estrogen signaling pathway_Homo sapiens_hsa049150.70385977
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70037582
92Bladder cancer_Homo sapiens_hsa052190.69655703
93Nitrogen metabolism_Homo sapiens_hsa009100.69140316
94Prolactin signaling pathway_Homo sapiens_hsa049170.68907710
95HTLV-I infection_Homo sapiens_hsa051660.68567800
96Prostate cancer_Homo sapiens_hsa052150.67277889
97Hematopoietic cell lineage_Homo sapiens_hsa046400.66782360
98Salmonella infection_Homo sapiens_hsa051320.66764650
99Tryptophan metabolism_Homo sapiens_hsa003800.66764420
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66567981
101Complement and coagulation cascades_Homo sapiens_hsa046100.64278265
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63816990
103Glycerolipid metabolism_Homo sapiens_hsa005610.63744974
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63608191
105Lysosome_Homo sapiens_hsa041420.62968931
106Endometrial cancer_Homo sapiens_hsa052130.62839380
107Legionellosis_Homo sapiens_hsa051340.59845410
108Endocytosis_Homo sapiens_hsa041440.59673220
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.59388158
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.59103347
111Autoimmune thyroid disease_Homo sapiens_hsa053200.58946784
112ErbB signaling pathway_Homo sapiens_hsa040120.58598101
113Colorectal cancer_Homo sapiens_hsa052100.58292172
114Pertussis_Homo sapiens_hsa051330.58008675
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57732869
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56798892
117Inositol phosphate metabolism_Homo sapiens_hsa005620.56434253
118MAPK signaling pathway_Homo sapiens_hsa040100.56116713
119Rap1 signaling pathway_Homo sapiens_hsa040150.56052125
120Starch and sucrose metabolism_Homo sapiens_hsa005000.55704468
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54729630
122Biosynthesis of amino acids_Homo sapiens_hsa012300.53920826
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52603371
124Arginine biosynthesis_Homo sapiens_hsa002200.51932284
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51791197
126Non-small cell lung cancer_Homo sapiens_hsa052230.51163110
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51050958
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50765900
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49363903
130Hepatitis C_Homo sapiens_hsa051600.49151072
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48220873

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