ANXA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of RIG-I signaling pathway (GO:0039535)4.11464769
2COPII vesicle coating (GO:0048208)3.96138216
3proteasome assembly (GO:0043248)3.83636783
4lactate metabolic process (GO:0006089)3.72473470
5negative regulation of execution phase of apoptosis (GO:1900118)3.61091498
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57774514
7L-phenylalanine metabolic process (GO:0006558)3.57774514
8low-density lipoprotein particle clearance (GO:0034383)3.48310649
9purine nucleotide salvage (GO:0032261)3.44153245
10regulation of type B pancreatic cell apoptotic process (GO:2000674)3.43876235
11protein maturation by protein folding (GO:0022417)3.43282316
12regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.42557142
13pteridine-containing compound biosynthetic process (GO:0042559)3.41555115
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29860235
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29860235
16tricarboxylic acid cycle (GO:0006099)3.24460159
17xenobiotic catabolic process (GO:0042178)3.24306086
18regulation of cellular amino acid metabolic process (GO:0006521)3.12902726
19succinate metabolic process (GO:0006105)3.12559838
20positive regulation of Cdc42 GTPase activity (GO:0043089)3.08677862
21desmosome organization (GO:0002934)3.04891555
22AMP metabolic process (GO:0046033)3.04463502
23regulation of hypersensitivity (GO:0002883)3.03324473
24regulation of mononuclear cell migration (GO:0071675)2.99560099
25respiratory chain complex IV assembly (GO:0008535)2.96895819
26cysteine metabolic process (GO:0006534)2.96214625
27antigen processing and presentation of endogenous antigen (GO:0019883)2.95886806
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.95415086
29L-phenylalanine catabolic process (GO:0006559)2.95415086
30mitochondrial calcium ion transport (GO:0006851)2.94595538
31natural killer cell mediated cytotoxicity (GO:0042267)2.93994426
32natural killer cell mediated immunity (GO:0002228)2.93994426
33regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.93149350
34branched-chain amino acid catabolic process (GO:0009083)2.92257813
35positive regulation of interferon-alpha production (GO:0032727)2.90857392
36positive regulation of actin filament depolymerization (GO:0030836)2.89438545
37immunoglobulin mediated immune response (GO:0016064)2.89078897
38hemidesmosome assembly (GO:0031581)2.86216513
39regulation of cholesterol storage (GO:0010885)2.86027949
40cellular response to interferon-alpha (GO:0035457)2.85213649
41regulation of female gonad development (GO:2000194)2.78817089
42cellular response to virus (GO:0098586)2.74940899
43growth hormone receptor signaling pathway (GO:0060396)2.73896017
44negative regulation of lipid storage (GO:0010888)2.73884245
45ER to Golgi vesicle-mediated transport (GO:0006888)2.72142475
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70850036
47regulation of interferon-alpha production (GO:0032647)2.70367272
48fibrinolysis (GO:0042730)2.68815473
49regulation of integrin-mediated signaling pathway (GO:2001044)2.65544705
50peptidyl-glutamic acid carboxylation (GO:0017187)2.64912918
51protein carboxylation (GO:0018214)2.64912918
52membrane budding (GO:0006900)2.64428297
53urate metabolic process (GO:0046415)2.61543590
54ribosome assembly (GO:0042255)2.61521320
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61413280
56cellular ketone body metabolic process (GO:0046950)2.61203153
57regulation of hexokinase activity (GO:1903299)2.61039959
58regulation of glucokinase activity (GO:0033131)2.61039959
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60911036
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60125065
61interferon-gamma secretion (GO:0072643)2.59800262
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58782421
63antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.57658263
64NADH metabolic process (GO:0006734)2.55699924
65urea metabolic process (GO:0019627)2.54550808
66urea cycle (GO:0000050)2.54550808
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54308231
68cytochrome complex assembly (GO:0017004)2.54201675
69regulation of metalloenzyme activity (GO:0048552)2.53926264
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52972651
71regulation of sequestering of triglyceride (GO:0010889)2.51267084
72bundle of His cell to Purkinje myocyte communication (GO:0086069)2.50805870
73sulfur amino acid catabolic process (GO:0000098)2.50548275
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50267335
75inositol phosphate dephosphorylation (GO:0046855)2.49360713
76phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49360713
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48633186
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47022932
79purine-containing compound salvage (GO:0043101)2.46618542
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46216764
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46216764
82hydrogen peroxide biosynthetic process (GO:0050665)2.45817997
83folic acid-containing compound biosynthetic process (GO:0009396)2.45691197
84wound healing, spreading of cells (GO:0044319)2.44938861
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44647743
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44647743
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44647743
88NIK/NF-kappaB signaling (GO:0038061)2.44307871
89branched-chain amino acid metabolic process (GO:0009081)2.43892597
90nucleotide-sugar biosynthetic process (GO:0009226)2.43800383
91regulation of mitochondrial translation (GO:0070129)2.42970759
92deoxyribose phosphate biosynthetic process (GO:0046385)2.41864093
932-deoxyribonucleotide biosynthetic process (GO:0009265)2.41864093
94lysine catabolic process (GO:0006554)2.41041889
95lysine metabolic process (GO:0006553)2.41041889
96organelle membrane fusion (GO:0090174)2.40799086
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40785406
98negative regulation of ligase activity (GO:0051352)2.40785406
99endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.39908537
100L-alpha-amino acid transmembrane transport (GO:1902475)2.39531983
101amino-acid betaine metabolic process (GO:0006577)2.38708731
102positive regulation of humoral immune response (GO:0002922)2.37303520
103regulation of glucocorticoid metabolic process (GO:0031943)2.36994020
104beta-amyloid metabolic process (GO:0050435)2.36808339
105valine metabolic process (GO:0006573)2.36379525
106signal transduction involved in DNA integrity checkpoint (GO:0072401)2.35767102
107signal transduction involved in DNA damage checkpoint (GO:0072422)2.35767102
108protein autoprocessing (GO:0016540)2.35638527
109positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.35029889
110B cell mediated immunity (GO:0019724)2.34913074
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.34423641
112deoxyribonucleotide biosynthetic process (GO:0009263)2.33730796
113negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.33368612
114cellular response to growth hormone stimulus (GO:0071378)2.32170383
115inositol phosphate catabolic process (GO:0071545)2.32154740
116cell adhesion mediated by integrin (GO:0033627)2.32149560
117positive regulation of ligase activity (GO:0051351)2.31242909
118response to hydroperoxide (GO:0033194)2.30877637
119oxaloacetate metabolic process (GO:0006107)2.30851071
120regulation of B cell apoptotic process (GO:0002902)2.30788214
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.30783634
122sphingosine metabolic process (GO:0006670)2.30701826
123positive regulation of protein autophosphorylation (GO:0031954)2.30504913
124response to interferon-alpha (GO:0035455)2.29770910
125rRNA methylation (GO:0031167)2.28812832
126regulation of cellular amine metabolic process (GO:0033238)2.28172764
127anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.27876334
128fibroblast migration (GO:0010761)2.27731976
129positive regulation of p38MAPK cascade (GO:1900745)2.27526621
130ketone body metabolic process (GO:1902224)2.27344088
131rRNA modification (GO:0000154)2.27210443
132intestinal epithelial cell development (GO:0060576)2.27157242
133regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27033280
134regulation of response to interferon-gamma (GO:0060330)2.26681915
135positive regulation of histone H3-K4 methylation (GO:0051571)2.26337188
136apoptotic cell clearance (GO:0043277)2.26127516
137positive regulation of interferon-beta production (GO:0032728)2.26055883
138sphingomyelin metabolic process (GO:0006684)2.25536551
139nitrogen cycle metabolic process (GO:0071941)2.25227128
140nitric oxide biosynthetic process (GO:0006809)2.24886615
141negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.24814900
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.23955191
143regulation of cholesterol homeostasis (GO:2000188)2.23933599
144positive regulation of macroautophagy (GO:0016239)2.23800778
145positive regulation of lipid storage (GO:0010884)2.23678586
146carnitine metabolic process (GO:0009437)2.23172839
147deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.22297449
148drug catabolic process (GO:0042737)2.21637324
149nucleoside salvage (GO:0043174)2.20342514
150complement activation, alternative pathway (GO:0006957)2.19775423
151heme biosynthetic process (GO:0006783)2.19474721
152positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.18865984
153fatty acid transmembrane transport (GO:1902001)2.18601943
154plasma lipoprotein particle clearance (GO:0034381)2.17734546
155regulation of protein activation cascade (GO:2000257)2.17651452
156fatty acid oxidation (GO:0019395)2.17162454
157vesicle coating (GO:0006901)2.16897598
158COPI coating of Golgi vesicle (GO:0048205)2.16720682
159Golgi transport vesicle coating (GO:0048200)2.16720682
160pteridine-containing compound metabolic process (GO:0042558)2.16641284
161positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.16522949
162regulation of complement activation (GO:0030449)2.15831924
163glycogen catabolic process (GO:0005980)2.15817411
164lipid oxidation (GO:0034440)2.15765268
165fatty acid beta-oxidation (GO:0006635)2.15439112
166myoblast migration (GO:0051451)2.15218067
167positive regulation of T cell apoptotic process (GO:0070234)2.15214740
168regulation of autophagic vacuole assembly (GO:2000785)2.15154677
169regulation of interferon-beta biosynthetic process (GO:0045357)2.15143485
170regulation of execution phase of apoptosis (GO:1900117)2.14917956
171mitochondrial calcium ion homeostasis (GO:0051560)2.14075961
172membrane raft organization (GO:0031579)2.14047801
173sequestering of metal ion (GO:0051238)2.13696125
174negative regulation of fatty acid biosynthetic process (GO:0045717)2.13668450
175positive regulation of natural killer cell differentiation (GO:0032825)2.13042392
176response to growth hormone (GO:0060416)2.12880277
177skin morphogenesis (GO:0043589)2.12546683
178regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.10951255
179modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.10445737
180positive regulation by organism of defense response of other organism involved in symbiotic interact2.10445737
181modulation by symbiont of host immune response (GO:0052553)2.10445737
182positive regulation by symbiont of host defense response (GO:0052509)2.10445737
183modulation by symbiont of host defense response (GO:0052031)2.10445737
184modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.10445737
185positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.09890794
186regulation of Cdc42 GTPase activity (GO:0043088)2.09675904
187JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.09417735
188surfactant homeostasis (GO:0043129)2.09391587
189transcytosis (GO:0045056)2.08785633
190regulation of proton transport (GO:0010155)2.07669605
191serine family amino acid catabolic process (GO:0009071)2.07156415
192hepatocyte apoptotic process (GO:0097284)2.06526639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.75678804
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.29487871
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.01566222
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.50697909
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.41895655
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33231196
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31425551
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.11322301
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.04885193
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86253620
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.85265988
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83919222
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.68962203
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67824602
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46798929
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.35562465
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.35264250
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.34453868
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.24813582
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.22654866
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.18290185
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17060518
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14859224
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14689695
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12162645
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.09775445
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.06061144
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05303274
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.98895271
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.98681088
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.94709862
32CLOCK_20551151_ChIP-Seq_293T_Human1.87419789
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84905780
34ZNF263_19887448_ChIP-Seq_K562_Human1.84707085
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.81000519
36* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80432446
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80120823
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74858818
39PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73681075
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73238532
41VDR_23849224_ChIP-Seq_CD4+_Human1.72598200
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.72022715
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.70315071
44AR_21909140_ChIP-Seq_LNCAP_Human1.70009086
45ATF3_27146783_Chip-Seq_COLON_Human1.68921943
46DCP1A_22483619_ChIP-Seq_HELA_Human1.68636870
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66278633
48ELK1_19687146_ChIP-ChIP_HELA_Human1.65600321
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64226295
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.61988961
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59144113
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57242660
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56838452
54IRF8_27001747_Chip-Seq_BMDM_Mouse1.55076956
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.54133043
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53940425
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53592528
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52406089
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.51516532
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.49501795
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47893613
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45191865
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45191865
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44772106
65SOX2_20726797_ChIP-Seq_SW620_Human1.41779888
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41560841
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39880062
68FOXP3_21729870_ChIP-Seq_TREG_Human1.39498479
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39298372
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38015602
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.33325744
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32266967
73* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30624288
74* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29897477
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29659206
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29607914
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28134991
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27907208
79HTT_18923047_ChIP-ChIP_STHdh_Human1.26568739
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24664138
81ELF5_23300383_ChIP-Seq_T47D_Human1.24053819
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23467124
83GATA4_25053715_ChIP-Seq_YYC3_Human1.22489576
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18864836
85GATA6_25053715_ChIP-Seq_YYC3_Human1.17764036
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17500282
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16551325
88CJUN_26792858_Chip-Seq_BT549_Human1.16332468
89* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16227218
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14662985
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14629225
92GATA1_22025678_ChIP-Seq_K562_Human1.13293728
93KDM5A_27292631_Chip-Seq_BREAST_Human1.13157861
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13068273
95JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12528721
96MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10341689
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09981245
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08789056
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08698919
100* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08566142
101* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07315159
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06657081
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05379769
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05025777
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04954891
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04697284
107RACK7_27058665_Chip-Seq_MCF-7_Human1.04550345
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.04366010
109* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03973317
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.03700323
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01944511
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99689875
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99657072
114* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99338961
115GABP_19822575_ChIP-Seq_HepG2_Human0.98782131
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96023087
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95640036
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95320965
119* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94726207
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94226423
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94043569
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93532851
123ELK1_22589737_ChIP-Seq_MCF10A_Human0.92505888
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90443870
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90315526
126HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90021490
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89049157
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87937528
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87880695
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.87352641
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86524452
132* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85162304
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83825969
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83588673
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83001978
136SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82294117
137MYB_26560356_Chip-Seq_TH2_Human0.81410356
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81314532
139TFEB_21752829_ChIP-Seq_HELA_Human0.80639099
140* UBF1/2_26484160_Chip-Seq_HMECs_Human0.79911560
141* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79191842
142* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78412508
143SPI1_23547873_ChIP-Seq_NB4_Human0.78141532
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77986940
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76553115
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75953815
147FOXM1_23109430_ChIP-Seq_U2OS_Human0.75381340
148GATA3_26560356_Chip-Seq_TH2_Human0.74850767
149* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74702559
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.73632784
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.73462152
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.72780046
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72721183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.22087633
2MP0002139_abnormal_hepatobiliary_system3.02620911
3MP0010234_abnormal_vibrissa_follicle2.96054853
4MP0003705_abnormal_hypodermis_morpholog2.73994179
5MP0002837_dystrophic_cardiac_calcinosis2.54161558
6MP0005451_abnormal_body_composition2.38640012
7MP0005379_endocrine/exocrine_gland_phen2.27690505
8MP0005360_urolithiasis2.24381302
9MP0006036_abnormal_mitochondrial_physio2.22886212
10MP0003566_abnormal_cell_adhesion2.22134164
11MP0002877_abnormal_melanocyte_morpholog2.19189385
12MP0009840_abnormal_foam_cell2.05369968
13MP0002138_abnormal_hepatobiliary_system2.01377111
14MP0003718_maternal_effect2.00255961
15MP0000013_abnormal_adipose_tissue1.99854348
16MP0005275_abnormal_skin_tensile1.93125390
17MP0003436_decreased_susceptibility_to1.92769112
18MP0003646_muscle_fatigue1.92667425
19MP0008875_abnormal_xenobiotic_pharmacok1.89183118
20MP0003724_increased_susceptibility_to1.88885502
21MP0010352_gastrointestinal_tract_polyps1.88710909
22MP0005365_abnormal_bile_salt1.87517209
23MP0002796_impaired_skin_barrier1.86770454
24MP0005085_abnormal_gallbladder_physiolo1.82556770
25MP0003453_abnormal_keratinocyte_physiol1.79998135
26MP0003191_abnormal_cellular_cholesterol1.77143227
27MP0002254_reproductive_system_inflammat1.74288867
28* MP0005464_abnormal_platelet_physiology1.72848021
29MP0004185_abnormal_adipocyte_glucose1.72032808
30MP0003186_abnormal_redox_activity1.70002875
31MP0009785_altered_susceptibility_to1.69457868
32MP0002163_abnormal_gland_morphology1.65528347
33MP0004947_skin_inflammation1.62987140
34MP0005058_abnormal_lysosome_morphology1.59751845
35MP0003806_abnormal_nucleotide_metabolis1.59431785
36MP0005023_abnormal_wound_healing1.57004543
37MP0001835_abnormal_antigen_presentation1.55479773
38* MP0002693_abnormal_pancreas_physiology1.54403650
39MP0001661_extended_life_span1.45321962
40MP0002876_abnormal_thyroid_physiology1.45254766
41MP0004782_abnormal_surfactant_physiolog1.44691027
42MP0003075_altered_response_to1.42757144
43MP0005165_increased_susceptibility_to1.41646432
44MP0005408_hypopigmentation1.40561160
45MP0002060_abnormal_skin_morphology1.39514857
46MP0003693_abnormal_embryo_hatching1.33227735
47MP0004510_myositis1.32042884
48MP0002909_abnormal_adrenal_gland1.30277504
49MP0005395_other_phenotype1.30152147
50MP0003656_abnormal_erythrocyte_physiolo1.29276545
51MP0008438_abnormal_cutaneous_collagen1.29125766
52* MP0001944_abnormal_pancreas_morphology1.27067902
53MP0010678_abnormal_skin_adnexa1.26584206
54MP0000685_abnormal_immune_system1.25897795
55MP0010329_abnormal_lipoprotein_level1.24743048
56MP0001533_abnormal_skeleton_physiology1.23258991
57MP0000343_altered_response_to1.22983319
58MP0000609_abnormal_liver_physiology1.22527810
59MP0003172_abnormal_lysosome_physiology1.22326571
60MP0003195_calcinosis1.21659679
61MP0006082_CNS_inflammation1.21036357
62MP0002148_abnormal_hypersensitivity_rea1.20106072
63MP0003786_premature_aging1.19677009
64MP0005636_abnormal_mineral_homeostasis1.19609217
65MP0002419_abnormal_innate_immunity1.18454119
66MP0001216_abnormal_epidermal_layer1.18405853
67MP0009764_decreased_sensitivity_to1.17645199
68MP0009643_abnormal_urine_homeostasis1.16822327
69MP0010386_abnormal_urinary_bladder1.16084212
70MP0006035_abnormal_mitochondrial_morpho1.16065112
71MP0005220_abnormal_exocrine_pancreas1.12927222
72MP0002006_tumorigenesis1.12446845
73MP0004264_abnormal_extraembryonic_tissu1.12132683
74MP0000858_altered_metastatic_potential1.11846618
75MP0005000_abnormal_immune_tolerance1.11311197
76MP0010368_abnormal_lymphatic_system1.11215971
77MP0003252_abnormal_bile_duct1.11143285
78MP0003303_peritoneal_inflammation1.11001287
79MP0005025_abnormal_response_to1.08969120
80MP0004019_abnormal_vitamin_homeostasis1.08390180
81MP0005319_abnormal_enzyme/_coenzyme1.08143976
82* MP0001845_abnormal_inflammatory_respons1.06463569
83MP0005501_abnormal_skin_physiology1.06054830
84MP0008469_abnormal_protein_level1.05000989
85MP0009697_abnormal_copulation1.04954618
86MP0003300_gastrointestinal_ulcer1.04884725
87MP0003091_abnormal_cell_migration1.04615890
88MP0005084_abnormal_gallbladder_morpholo1.04126012
89MP0004036_abnormal_muscle_relaxation1.03940263
90MP0000358_abnormal_cell_content/1.03352183
91MP0002078_abnormal_glucose_homeostasis1.03310080
92MP0005310_abnormal_salivary_gland1.03214741
93MP0010155_abnormal_intestine_physiology1.02178088
94MP0001666_abnormal_nutrient_absorption1.01995422
95MP0006054_spinal_hemorrhage1.01942100
96MP0005330_cardiomyopathy1.01889298
97MP0008007_abnormal_cellular_replicative1.01746055
98MP0001545_abnormal_hematopoietic_system1.01735101
99MP0005397_hematopoietic_system_phenotyp1.01735101
100MP0003448_altered_tumor_morphology1.01718583
101MP0000003_abnormal_adipose_tissue1.01593209
102MP0003950_abnormal_plasma_membrane1.00160767
103MP0002090_abnormal_vision0.99482847
104MP0001756_abnormal_urination0.95984121
105MP0005387_immune_system_phenotype0.94686262
106MP0001790_abnormal_immune_system0.94686262
107MP0005332_abnormal_amino_acid0.92984447
108MP0008058_abnormal_DNA_repair0.92663923
109MP0002136_abnormal_kidney_physiology0.91402492
110MP0002452_abnormal_antigen_presenting0.90357381
111MP0009763_increased_sensitivity_to0.88806928
112MP0005083_abnormal_biliary_tract0.88513327
113MP0001764_abnormal_homeostasis0.87969571
114MP0010307_abnormal_tumor_latency0.87470969
115MP0001727_abnormal_embryo_implantation0.87193620
116MP0005666_abnormal_adipose_tissue0.87147757
117MP0002295_abnormal_pulmonary_circulatio0.86300414
118MP0002166_altered_tumor_susceptibility0.85760752
119MP0005075_abnormal_melanosome_morpholog0.85211788
120MP0000598_abnormal_liver_morphology0.84396020
121MP0005076_abnormal_cell_differentiation0.83938564
122MP0001800_abnormal_humoral_immune0.83254513
123MP0005535_abnormal_body_temperature0.83209973
124MP0003868_abnormal_feces_composition0.83138779
125MP0003045_fibrosis0.83018522
126MP0002723_abnormal_immune_serum0.81768065
127MP0000579_abnormal_nail_morphology0.81258935
128MP0002405_respiratory_system_inflammati0.81204032
129MP0002332_abnormal_exercise_endurance0.81085802
130* MP0001765_abnormal_ion_homeostasis0.80677761
131MP0005670_abnormal_white_adipose0.79789720
132MP0005584_abnormal_enzyme/coenzyme_acti0.79407380
133MP0004130_abnormal_muscle_cell0.78987092
134MP0003763_abnormal_thymus_physiology0.78099111
135MP0005166_decreased_susceptibility_to0.77479218
136MP0001853_heart_inflammation0.77304486
137MP0004215_abnormal_myocardial_fiber0.76716713
138MP0002168_other_aberrant_phenotype0.76495575
139MP0002118_abnormal_lipid_homeostasis0.76126740
140MP0001243_abnormal_dermal_layer0.75758682
141MP0000627_abnormal_mammary_gland0.74959363
142MP0005167_abnormal_blood-brain_barrier0.74588276
143MP0001881_abnormal_mammary_gland0.74375679
144MP0001849_ear_inflammation0.72756834

Predicted human phenotypes

RankGene SetZ-score
1Hypokinesia (HP:0002375)3.55042345
2Deep venous thrombosis (HP:0002625)3.49083909
3Abnormality of glycolipid metabolism (HP:0010969)3.38863254
4Abnormality of liposaccharide metabolism (HP:0010968)3.38863254
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.38863254
6Right ventricular cardiomyopathy (HP:0011663)3.33856819
7Eczematoid dermatitis (HP:0000976)3.29415330
8Autoimmune thrombocytopenia (HP:0001973)3.19562165
9Myocardial infarction (HP:0001658)3.11622360
10Ketoacidosis (HP:0001993)3.08265722
11Recurrent gram-negative bacterial infections (HP:0005420)3.00321638
12Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99165092
13Petechiae (HP:0000967)2.94065176
14Xanthomatosis (HP:0000991)2.93501532
15Palpitations (HP:0001962)2.93218596
16Tetraparesis (HP:0002273)2.87673063
17Progressive neurologic deterioration (HP:0002344)2.87655610
18Hypoglycemic seizures (HP:0002173)2.85668574
19Intrahepatic cholestasis (HP:0001406)2.82021179
20Hyperinsulinemic hypoglycemia (HP:0000825)2.82009283
21Male infertility (HP:0003251)2.74462914
22Tongue fasciculations (HP:0001308)2.71999815
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.67819614
24Hepatic necrosis (HP:0002605)2.65300189
25Esophageal varix (HP:0002040)2.62762843
26Recurrent bacterial skin infections (HP:0005406)2.54246017
27Systemic lupus erythematosus (HP:0002725)2.54184495
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51675602
29Type I transferrin isoform profile (HP:0003642)2.50699801
30Vascular calcification (HP:0004934)2.39639990
31Loss of speech (HP:0002371)2.38770943
32Abnormality of the common coagulation pathway (HP:0010990)2.38729963
33Interstitial pulmonary disease (HP:0006530)2.37999987
34Gout (HP:0001997)2.37812174
35Abnormality of purine metabolism (HP:0004352)2.37706982
36Recurrent abscess formation (HP:0002722)2.36860481
37Increased CSF protein (HP:0002922)2.36596245
38Muscle fibrillation (HP:0010546)2.36210679
39Dysostosis multiplex (HP:0000943)2.35954816
40Symptomatic seizures (HP:0011145)2.35161852
41Hypoglycemic coma (HP:0001325)2.34743116
42Orchitis (HP:0100796)2.33022092
43Hyperglycemia (HP:0003074)2.31047324
44Osteolytic defects of the hand bones (HP:0009699)2.29682796
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.29682796
46Increased connective tissue (HP:0009025)2.29518694
47Nausea (HP:0002018)2.27522683
48Hydroxyprolinuria (HP:0003080)2.27151693
49Abnormality of proline metabolism (HP:0010907)2.27151693
50Complement deficiency (HP:0004431)2.27019370
51Rhabdomyolysis (HP:0003201)2.25886918
52Hypoalphalipoproteinemia (HP:0003233)2.25340264
53Hepatocellular necrosis (HP:0001404)2.25091403
54Abnormal protein N-linked glycosylation (HP:0012347)2.23283057
55Abnormal protein glycosylation (HP:0012346)2.23283057
56Abnormal glycosylation (HP:0012345)2.23283057
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23283057
58Peritonitis (HP:0002586)2.22713904
59Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21459244
60Steatorrhea (HP:0002570)2.20314286
61Vacuolated lymphocytes (HP:0001922)2.18655086
62Renal Fanconi syndrome (HP:0001994)2.18125170
63Abnormality of macrophages (HP:0004311)2.18044843
64Cardiovascular calcification (HP:0011915)2.18034830
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17913461
66Malnutrition (HP:0004395)2.16715381
67Cortical dysplasia (HP:0002539)2.16026257
68Ankle contracture (HP:0006466)2.15708820
69Abnormality of complement system (HP:0005339)2.15060990
70Reduced antithrombin III activity (HP:0001976)2.14771489
71Polycythemia (HP:0001901)2.14395209
72Myositis (HP:0100614)2.14209198
73Progressive macrocephaly (HP:0004481)2.12221215
74Cervical subluxation (HP:0003308)2.11851449
75Abnormality of methionine metabolism (HP:0010901)2.11301040
76Vertebral compression fractures (HP:0002953)2.10146053
77Generalized aminoaciduria (HP:0002909)2.09948528
78Pustule (HP:0200039)2.09674287
79Plantar hyperkeratosis (HP:0007556)2.08181284
80Orthostatic hypotension (HP:0001278)2.05821569
81Protrusio acetabuli (HP:0003179)2.05402687
82Increased CSF lactate (HP:0002490)2.05282142
83Neonatal death (HP:0003811)2.04888367
84Mitochondrial inheritance (HP:0001427)2.04245725
85Thick nail (HP:0001805)2.04192348
86Abnormality of nucleobase metabolism (HP:0010932)2.03842386
87Ketosis (HP:0001946)2.03636922
88Dicarboxylic aciduria (HP:0003215)2.03625687
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03625687
90Short nail (HP:0001799)2.03488340
91Hyperglycinuria (HP:0003108)2.03367988
92Abnormal mitochondria in muscle tissue (HP:0008316)2.02893394
93Insulin-resistant diabetes mellitus (HP:0000831)2.02329387
94Large for gestational age (HP:0001520)2.00059042
95Acute necrotizing encephalopathy (HP:0006965)1.99420819
96Glucose intolerance (HP:0000833)1.99235198
97Myoglobinuria (HP:0002913)1.98861224
98Neuroendocrine neoplasm (HP:0100634)1.98513307
99Abnormal cartilage morphology (HP:0002763)1.95926578
100Prolonged neonatal jaundice (HP:0006579)1.95407663
101Abnormality of vitamin metabolism (HP:0100508)1.94917065
102Nemaline bodies (HP:0003798)1.94602634
103Alopecia of scalp (HP:0002293)1.94319006
104Abnormality of endocrine pancreas physiology (HP:0012093)1.93968224
105Abnormality of the pancreatic islet cells (HP:0006476)1.93968224
106Hamartoma of the eye (HP:0010568)1.93797474
107Abnormality of the intrinsic pathway (HP:0010989)1.93759990
108Hyperammonemia (HP:0001987)1.93726501
109Neoplasm of the adrenal gland (HP:0100631)1.93321258
110Abnormality of fatty-acid metabolism (HP:0004359)1.92031339
111Increased cerebral lipofuscin (HP:0011813)1.90270024
112Distal lower limb muscle weakness (HP:0009053)1.90143650
113Abnormality of vitamin B metabolism (HP:0004340)1.89656205
114Degeneration of anterior horn cells (HP:0002398)1.87096886
115Abnormality of the anterior horn cell (HP:0006802)1.87096886
116Nephritis (HP:0000123)1.87094640
117Abnormality of glycolysis (HP:0004366)1.86431566
118Respiratory failure (HP:0002878)1.85726409
119Abnormality of transition element cation homeostasis (HP:0011030)1.84283179
120Arterial thrombosis (HP:0004420)1.84271554
121Hypolipoproteinemia (HP:0010981)1.84227379
122Insulin resistance (HP:0000855)1.84205467
123Diminished movement (HP:0002374)1.83798569
124Acute encephalopathy (HP:0006846)1.83774810
125Hyperthyroidism (HP:0000836)1.83181123
126Palmoplantar hyperkeratosis (HP:0000972)1.82560691
127Proximal tubulopathy (HP:0000114)1.81629387
128Cholecystitis (HP:0001082)1.81627762
129Gastrointestinal infarctions (HP:0005244)1.81376689
130Abnormal gallbladder morphology (HP:0012437)1.80740668
131Abnormality of iron homeostasis (HP:0011031)1.80460765
132Increased IgE level (HP:0003212)1.80125416
133Increased intramyocellular lipid droplets (HP:0012240)1.80087687
1343-Methylglutaconic aciduria (HP:0003535)1.79557438
135Abnormality of the basal ganglia (HP:0002134)1.79396172
136Methylmalonic acidemia (HP:0002912)1.79128775
137Ulnar deviation of the wrist (HP:0003049)1.79044949
138Abnormality of the distal phalanges of the toes (HP:0010182)1.78530186
139Cardiomegaly (HP:0001640)1.78438534
140Fatigue (HP:0012378)1.78233557
141Acanthosis nigricans (HP:0000956)1.77321543
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77294235
143Abnormality of polysaccharide metabolism (HP:0011012)1.77294235
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77294235
145Increased serum pyruvate (HP:0003542)1.76791054
146Fat malabsorption (HP:0002630)1.76732100
147Lower limb hyperreflexia (HP:0002395)1.76713469
148Hematochezia (HP:0002573)1.75856550
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75543945
150Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75543945
151Asymmetric septal hypertrophy (HP:0001670)1.75339976
152Abnormal hemoglobin (HP:0011902)1.75335702
153Increased purine levels (HP:0004368)1.74159427
154Hyperuricemia (HP:0002149)1.74159427
155Axonal loss (HP:0003447)1.73915484
156Lactic acidosis (HP:0003128)1.73875377
157Beaking of vertebral bodies (HP:0004568)1.73607902
158Mucopolysacchariduria (HP:0008155)1.72096985
159Urinary glycosaminoglycan excretion (HP:0003541)1.72096985
160Prolonged partial thromboplastin time (HP:0003645)1.71889449
161Pancreatitis (HP:0001733)1.71581359
162Metaphyseal dysplasia (HP:0100255)1.71071637
163Lethargy (HP:0001254)1.71038032
164Optic neuritis (HP:0100653)1.70427363
165Retrobulbar optic neuritis (HP:0100654)1.70427363
166Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.70290057
167Increased muscle lipid content (HP:0009058)1.70224179
168Conjunctival hamartoma (HP:0100780)1.70172185
169Epidermoid cyst (HP:0200040)1.69009096
170Anorexia (HP:0002039)1.68699893
171Pheochromocytoma (HP:0002666)1.68594750
172Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67639706
173Increased mean platelet volume (HP:0011877)1.67566198
174Lipid accumulation in hepatocytes (HP:0006561)1.67530171
175Exercise-induced myalgia (HP:0003738)1.67109689
176Premature rupture of membranes (HP:0001788)1.66990993
177Abnormality of sulfur amino acid metabolism (HP:0004339)1.66932999
178Milia (HP:0001056)1.66651760
179Hepatocellular carcinoma (HP:0001402)1.66313624
180Difficulty climbing stairs (HP:0003551)1.65956781
181Multiple enchondromatosis (HP:0005701)1.64457451
182Onycholysis (HP:0001806)1.64232447
183Hemorrhage of the eye (HP:0011885)1.63816315
184Abnormal gallbladder physiology (HP:0012438)1.63793971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.25287920
2MAPKAPK32.86721923
3MOS2.75567756
4SCYL22.68343382
5TAOK32.60806796
6MAP3K132.54410138
7KSR22.47560154
8ARAF2.31481839
9LATS12.29748678
10TRIB32.24208999
11ERN12.23292010
12EEF2K2.08967308
13LATS22.05792353
14PHKG12.01828062
15PHKG22.01828062
16ERBB41.97471137
17TBK11.89955348
18TYK21.86817900
19MAP3K31.85737302
20STK38L1.83544225
21TESK11.83388950
22MYLK1.77310590
23MAP3K141.76660595
24BMPR21.75678151
25NEK91.72977085
26STK101.70164424
27MAP3K91.68392863
28MST1R1.65610750
29PKN21.63061568
30MAP3K61.61009358
31TAOK11.60481793
32BUB11.59705897
33STK31.57353453
34FRK1.47487113
35TRPM71.46173617
36PLK41.44976619
37ABL21.44585585
38BRAF1.43162232
39PIM21.43084106
40LRRK21.40287666
41JAK31.39643587
42RAF11.36816760
43EPHA21.30742017
44NME21.30406821
45STK161.29958044
46STK241.27304021
47TTN1.22406846
48TTK1.21463239
49LIMK11.20483858
50FGFR41.19621309
51ERBB31.18105223
52RPS6KB21.17872611
53EPHA31.16988738
54LMTK21.15240051
55RPS6KA41.12946206
56BCKDK1.11561874
57DAPK11.10806227
58MAP2K61.10304205
59IKBKE1.10082840
60JAK11.09595739
61MAP3K21.06378987
62IRAK31.01961462
63MAP2K11.01643849
64TRIM281.00870575
65MAP3K11.00607646
66MAP3K111.00315396
67FER0.99717054
68IKBKB0.92813576
69JAK20.90824960
70MAP3K80.89892978
71FLT30.89711396
72RIPK10.88619498
73MAP3K50.88255978
74NLK0.88204189
75MAP2K30.86478021
76MST40.81683175
77KIT0.80849393
78PTK2B0.78746138
79CHUK0.78585957
80MAP3K120.77686506
81VRK20.77338003
82ACVR1B0.76292300
83CAMK2D0.72852176
84ILK0.72748063
85PTK60.72294248
86CDK90.72137662
87ZAK0.71560228
88RIPK40.71500296
89NEK10.69937436
90TGFBR20.69782817
91NUAK10.68541253
92PIM10.68139598
93NME10.67825420
94IRAK10.66766119
95PIK3CG0.66328042
96CSNK1G10.64882095
97ZAP700.64824952
98EIF2AK20.64568842
99PLK30.64492605
100OBSCN0.63975814
101RET0.63859427
102MATK0.63350078
103PTK20.62621768
104CSNK1G30.61195435
105STK40.60592587
106KDR0.60026122
107MUSK0.58714036
108MAPK110.58013127
109SIK30.57401243
110MELK0.57386832
111GRK10.57160808
112FGFR30.55532334
113TEC0.53812519
114PRKCI0.53662070
115HIPK20.51629426
116TXK0.51003068
117TIE10.50781728
118TSSK60.48588516
119DAPK30.48174550
120PDK20.48031068
121PRKAA20.47587987
122BMX0.46851570
123PINK10.46002045
124TGFBR10.45332293
125PAK40.45096933
126CAMK2G0.44514632
127CDK60.41900223
128MET0.39740618
129ABL10.38781600
130DAPK20.38652703
131PAK10.37882469
132PBK0.36466193
133DMPK0.34964113
134EPHB10.34938121
135PRKCE0.34002856
136TAOK20.33748280
137NEK20.32614773
138EIF2AK10.32545076
139PASK0.32524226
140TESK20.32242788
141MAP4K10.32202578
142CSK0.32109216
143MAPKAPK20.31693204
144PRKG20.31646382

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.92963698
2Sulfur metabolism_Homo sapiens_hsa009203.06328195
3Fatty acid elongation_Homo sapiens_hsa000623.00767827
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.77719469
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.67695194
6Caffeine metabolism_Homo sapiens_hsa002322.61750025
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44887958
8Protein export_Homo sapiens_hsa030602.40653853
9Vitamin B6 metabolism_Homo sapiens_hsa007502.32753073
10SNARE interactions in vesicular transport_Homo sapiens_hsa041302.14542342
11Staphylococcus aureus infection_Homo sapiens_hsa051501.94118520
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.93091546
13Arginine biosynthesis_Homo sapiens_hsa002201.87652636
14Complement and coagulation cascades_Homo sapiens_hsa046101.85190252
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74296433
16Type I diabetes mellitus_Homo sapiens_hsa049401.68605900
17Fatty acid degradation_Homo sapiens_hsa000711.67745219
18Leishmaniasis_Homo sapiens_hsa051401.63410191
19Collecting duct acid secretion_Homo sapiens_hsa049661.54784371
20Butanoate metabolism_Homo sapiens_hsa006501.52568504
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52296091
22Oxidative phosphorylation_Homo sapiens_hsa001901.45319698
23Legionellosis_Homo sapiens_hsa051341.43799141
24Tryptophan metabolism_Homo sapiens_hsa003801.40979277
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39570074
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39036555
27Other glycan degradation_Homo sapiens_hsa005111.35388848
28PPAR signaling pathway_Homo sapiens_hsa033201.33117612
29TNF signaling pathway_Homo sapiens_hsa046681.32820552
30Folate biosynthesis_Homo sapiens_hsa007901.32461617
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30361043
32Vibrio cholerae infection_Homo sapiens_hsa051101.29705281
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28506681
34Sphingolipid metabolism_Homo sapiens_hsa006001.27408704
35Toxoplasmosis_Homo sapiens_hsa051451.26387402
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25923330
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24024578
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19007926
39Phenylalanine metabolism_Homo sapiens_hsa003601.15878937
40Lysosome_Homo sapiens_hsa041421.13836816
41Ovarian steroidogenesis_Homo sapiens_hsa049131.13058678
42Histidine metabolism_Homo sapiens_hsa003401.12984035
43Amoebiasis_Homo sapiens_hsa051461.12872607
44Apoptosis_Homo sapiens_hsa042101.12815196
45Fructose and mannose metabolism_Homo sapiens_hsa000511.12706831
46N-Glycan biosynthesis_Homo sapiens_hsa005101.12571866
47NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11441838
48Influenza A_Homo sapiens_hsa051641.11416430
49p53 signaling pathway_Homo sapiens_hsa041151.11246758
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10837476
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09172199
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08689668
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08438089
54Chemical carcinogenesis_Homo sapiens_hsa052041.07939348
55Mismatch repair_Homo sapiens_hsa034301.07165806
56Malaria_Homo sapiens_hsa051441.06072857
57Pancreatic cancer_Homo sapiens_hsa052121.05906576
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.04508204
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04185299
60Pertussis_Homo sapiens_hsa051331.00849602
61Thyroid cancer_Homo sapiens_hsa052160.99532851
62One carbon pool by folate_Homo sapiens_hsa006700.98716058
63beta-Alanine metabolism_Homo sapiens_hsa004100.98422471
64Graft-versus-host disease_Homo sapiens_hsa053320.97832991
65Starch and sucrose metabolism_Homo sapiens_hsa005000.95181460
66Peroxisome_Homo sapiens_hsa041460.94057273
67Tuberculosis_Homo sapiens_hsa051520.93491869
68Prolactin signaling pathway_Homo sapiens_hsa049170.92255844
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91710834
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91440721
71Selenocompound metabolism_Homo sapiens_hsa004500.91294309
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.91205200
73Shigellosis_Homo sapiens_hsa051310.90682076
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89449303
75Pentose phosphate pathway_Homo sapiens_hsa000300.89403854
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.89006078
77Adherens junction_Homo sapiens_hsa045200.88533587
78Parkinsons disease_Homo sapiens_hsa050120.86233165
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85635661
80Rheumatoid arthritis_Homo sapiens_hsa053230.85448209
81Small cell lung cancer_Homo sapiens_hsa052220.83458851
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83148051
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83045025
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82754264
85Osteoclast differentiation_Homo sapiens_hsa043800.82468467
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.82246126
87Linoleic acid metabolism_Homo sapiens_hsa005910.81874677
88Insulin resistance_Homo sapiens_hsa049310.81860770
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.80044025
90Bladder cancer_Homo sapiens_hsa052190.79827323
91Propanoate metabolism_Homo sapiens_hsa006400.79191862
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79052976
93Measles_Homo sapiens_hsa051620.78557710
94Allograft rejection_Homo sapiens_hsa053300.78405434
95Hepatitis C_Homo sapiens_hsa051600.76807685
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.74906051
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73857626
98Non-homologous end-joining_Homo sapiens_hsa034500.73738848
99Antigen processing and presentation_Homo sapiens_hsa046120.73693060
100Metabolic pathways_Homo sapiens_hsa011000.72720746
101Carbon metabolism_Homo sapiens_hsa012000.72707393
102Glutathione metabolism_Homo sapiens_hsa004800.71326201
103Herpes simplex infection_Homo sapiens_hsa051680.70985519
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70809719
105Nucleotide excision repair_Homo sapiens_hsa034200.69689428
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69615169
107Regulation of autophagy_Homo sapiens_hsa041400.68110044
108Hepatitis B_Homo sapiens_hsa051610.66417656
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63350299
110Retinol metabolism_Homo sapiens_hsa008300.63148515
111Galactose metabolism_Homo sapiens_hsa000520.62960192
112TGF-beta signaling pathway_Homo sapiens_hsa043500.62512160
113Nitrogen metabolism_Homo sapiens_hsa009100.62409768
114Tyrosine metabolism_Homo sapiens_hsa003500.61606609
115Biosynthesis of amino acids_Homo sapiens_hsa012300.61577402
116Pyrimidine metabolism_Homo sapiens_hsa002400.61136472
117Phagosome_Homo sapiens_hsa041450.59393915
118Circadian rhythm_Homo sapiens_hsa047100.59263270
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59257507
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.58114131
121Purine metabolism_Homo sapiens_hsa002300.58059559
122Salmonella infection_Homo sapiens_hsa051320.57868471
123Fatty acid metabolism_Homo sapiens_hsa012120.57832626
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56865470
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56772415
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56657760
127VEGF signaling pathway_Homo sapiens_hsa043700.55049964
128Pyruvate metabolism_Homo sapiens_hsa006200.54752071
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54417837
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54347151
131Alzheimers disease_Homo sapiens_hsa050100.54314202
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.53918216
133Bile secretion_Homo sapiens_hsa049760.53868340
134Vitamin digestion and absorption_Homo sapiens_hsa049770.52226232
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51066974
136FoxO signaling pathway_Homo sapiens_hsa040680.50777021
137Acute myeloid leukemia_Homo sapiens_hsa052210.50695607
138Fat digestion and absorption_Homo sapiens_hsa049750.50550067
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50200168
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45408776
141Mineral absorption_Homo sapiens_hsa049780.40802969
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40054640
143Arginine and proline metabolism_Homo sapiens_hsa003300.38379984
144Arachidonic acid metabolism_Homo sapiens_hsa005900.37507356
145Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33699420
146RNA polymerase_Homo sapiens_hsa030200.30251322
147RNA degradation_Homo sapiens_hsa030180.29973208

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