ANXA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.47188387
2regulation of water loss via skin (GO:0033561)8.04845708
3hemidesmosome assembly (GO:0031581)7.97372735
4keratinocyte proliferation (GO:0043616)7.84793800
5keratinization (GO:0031424)7.11730626
6cell-substrate junction assembly (GO:0007044)6.94208489
7sphingoid metabolic process (GO:0046519)6.64784541
8keratinocyte differentiation (GO:0030216)6.34812388
9sphingosine metabolic process (GO:0006670)5.80241130
10viral transcription (GO:0019083)5.70706782
11multicellular organismal water homeostasis (GO:0050891)5.60637063
12translational termination (GO:0006415)5.37641471
13molting cycle (GO:0042303)5.29575659
14hair cycle (GO:0042633)5.29575659
15ribosomal small subunit biogenesis (GO:0042274)5.24071889
16diol metabolic process (GO:0034311)5.23798775
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.07751520
18positive regulation of epidermal cell differentiation (GO:0045606)5.06506355
19keratinocyte development (GO:0003334)5.03598304
20epidermal cell differentiation (GO:0009913)5.01086830
21regulation of transforming growth factor beta2 production (GO:0032909)5.00558367
22epidermis development (GO:0008544)4.90216708
23intermediate filament organization (GO:0045109)4.80987706
24peptide cross-linking (GO:0018149)4.76878955
25water homeostasis (GO:0030104)4.74429347
26regulation of chemokine secretion (GO:0090196)4.74196106
27interferon-gamma secretion (GO:0072643)4.73018984
28gap junction assembly (GO:0016264)4.65595967
29negative regulation of keratinocyte proliferation (GO:0010839)4.60882926
30surfactant homeostasis (GO:0043129)4.56037073
31glucosamine-containing compound catabolic process (GO:1901072)4.55111120
32polarized epithelial cell differentiation (GO:0030859)4.52455036
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.47271468
34protein targeting to ER (GO:0045047)4.40682633
35cotranslational protein targeting to membrane (GO:0006613)4.36582938
36cell adhesion mediated by integrin (GO:0033627)4.30201031
37establishment of protein localization to endoplasmic reticulum (GO:0072599)4.27705495
38translational elongation (GO:0006414)4.27095504
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.25577957
40viral life cycle (GO:0019058)4.24335317
41establishment of planar polarity (GO:0001736)4.19611100
42establishment of tissue polarity (GO:0007164)4.19611100
43positive regulation of chemokine secretion (GO:0090197)4.18752600
44regulation of ruffle assembly (GO:1900027)4.18317342
45protein localization to endoplasmic reticulum (GO:0070972)4.10932087
46positive regulation of vesicle fusion (GO:0031340)4.07267094
47cellular protein complex disassembly (GO:0043624)4.07069825
48skin morphogenesis (GO:0043589)4.06845451
49maturation of SSU-rRNA (GO:0030490)4.06132760
50positive regulation of interleukin-8 secretion (GO:2000484)4.00854332
51positive regulation of keratinocyte differentiation (GO:0045618)4.00777347
52atrioventricular valve morphogenesis (GO:0003181)3.94350250
53membrane raft organization (GO:0031579)3.92686743
54fatty acid elongation (GO:0030497)3.89934821
55epithelial cell differentiation involved in prostate gland development (GO:0060742)3.84990732
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79299896
57regulation of interleukin-8 secretion (GO:2000482)3.78527529
58ribosomal small subunit assembly (GO:0000028)3.77455481
59chemical homeostasis within a tissue (GO:0048875)3.72776153
60regulation of cell proliferation involved in kidney development (GO:1901722)3.71946891
61negative regulation of chondrocyte differentiation (GO:0032331)3.66861784
62long-chain fatty acid biosynthetic process (GO:0042759)3.66303363
63limb bud formation (GO:0060174)3.63699313
64lateral sprouting from an epithelium (GO:0060601)3.63101061
65negative regulation of acute inflammatory response (GO:0002674)3.60760747
66gland morphogenesis (GO:0022612)3.56265017
67intestinal epithelial cell development (GO:0060576)3.50936022
68morphogenesis of embryonic epithelium (GO:0016331)3.48851741
69hypotonic response (GO:0006971)3.48643019
70regulation of hypersensitivity (GO:0002883)3.46978808
71cyclooxygenase pathway (GO:0019371)3.46193097
72regulation of hair cycle (GO:0042634)3.43645294
73protein autoprocessing (GO:0016540)3.43600287
74prostanoid biosynthetic process (GO:0046457)3.38994131
75prostaglandin biosynthetic process (GO:0001516)3.38994131
76mesodermal cell differentiation (GO:0048333)3.37254657
77negative regulation of interferon-gamma production (GO:0032689)3.35918262
78positive regulation of hair follicle development (GO:0051798)3.33673172
79positive regulation of hair cycle (GO:0042635)3.33673172
80protein complex disassembly (GO:0043241)3.32277558
81translational initiation (GO:0006413)3.31720115
82detection of bacterium (GO:0016045)3.31218523
83cell-substrate adherens junction assembly (GO:0007045)3.28843694
84focal adhesion assembly (GO:0048041)3.28843694
85positive regulation of epidermis development (GO:0045684)3.27609231
86protein targeting to membrane (GO:0006612)3.26751583
87heart valve morphogenesis (GO:0003179)3.25762069
88cell junction assembly (GO:0034329)3.24398606
89regulation of G0 to G1 transition (GO:0070316)3.23951842
90ribosomal large subunit biogenesis (GO:0042273)3.22196929
91G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.21199839
92cornea development in camera-type eye (GO:0061303)3.19913054
93retinal metabolic process (GO:0042574)3.19572075
94cardiac right ventricle morphogenesis (GO:0003215)3.17896318
95diterpenoid biosynthetic process (GO:0016102)3.17114801
96skin development (GO:0043588)3.15780871
97ectoderm development (GO:0007398)3.09012442
98cell junction organization (GO:0034330)3.08805202
99regulation of epidermal cell differentiation (GO:0045604)3.07862929
100eyelid development in camera-type eye (GO:0061029)3.07500550
101regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07071065
102regulation of glomerular filtration (GO:0003093)3.06532178
103macromolecular complex disassembly (GO:0032984)3.05741438
104planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04759371
105primary alcohol catabolic process (GO:0034310)3.03064011
106positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.02289027
107regulation of cardioblast differentiation (GO:0051890)3.01010851
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00994890
109negative regulation of interleukin-2 production (GO:0032703)3.00685405
110negative regulation of stem cell proliferation (GO:2000647)3.00218560
111negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.99650381
112terpenoid biosynthetic process (GO:0016114)2.98462282
113cellular response to interferon-alpha (GO:0035457)2.98249397
114long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.96656189
115positive regulation of odontogenesis (GO:0042482)2.96405176
116prostanoid metabolic process (GO:0006692)2.95804181
117prostaglandin metabolic process (GO:0006693)2.95804181
118membrane budding (GO:0006900)2.95729257
119regulation of keratinocyte proliferation (GO:0010837)2.94484985
120regulation of transforming growth factor beta1 production (GO:0032908)2.92467061
121regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.91986445
122amyloid precursor protein metabolic process (GO:0042982)2.91678281
123ventricular cardiac muscle cell action potential (GO:0086005)2.91471085
124negative regulation of epidermis development (GO:0045683)2.91394981
125neural crest cell development (GO:0014032)2.87996562
126regulation of hair follicle development (GO:0051797)2.87577231
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.87387986
128negative regulation of cartilage development (GO:0061037)2.87202990
129cytoskeletal anchoring at plasma membrane (GO:0007016)2.86565797
130lymph vessel development (GO:0001945)2.86299287
131icosanoid secretion (GO:0032309)2.84309742
132arachidonic acid secretion (GO:0050482)2.84309742
133protein retention in ER lumen (GO:0006621)2.84041652
134epithelial cell-cell adhesion (GO:0090136)2.83997954
135negative regulation of cell fate specification (GO:0009996)2.82310662
136negative regulation of cell fate commitment (GO:0010454)2.81096465
137phosphatidylinositol acyl-chain remodeling (GO:0036149)2.80663857
138detection of other organism (GO:0098543)2.80412201
139intermediate filament cytoskeleton organization (GO:0045104)2.79408832
140mammary gland epithelial cell proliferation (GO:0033598)2.77800220
141negative regulation of T cell mediated immunity (GO:0002710)2.77532527
142phosphatidylserine acyl-chain remodeling (GO:0036150)2.76831832
143regulation of epidermis development (GO:0045682)2.76266153
144epithelium development (GO:0060429)2.75307735
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75088126
146regulation of transforming growth factor beta production (GO:0071634)2.73865638
147activation of Rac GTPase activity (GO:0032863)2.73595898
148adherens junction assembly (GO:0034333)2.72846367
149cell differentiation involved in embryonic placenta development (GO:0060706)2.71963351
150cardiolipin metabolic process (GO:0032048)2.71329530
151L-serine transport (GO:0015825)2.70939505
152regulation of keratinocyte differentiation (GO:0045616)2.70793867
153intermediate filament-based process (GO:0045103)2.70345318
154protein localization to endosome (GO:0036010)2.69901134
155endodermal cell differentiation (GO:0035987)2.67519102
156cell-cell junction assembly (GO:0007043)2.65807502
157regulation of metalloenzyme activity (GO:0048552)2.62820578
158hair follicle morphogenesis (GO:0031069)2.60695174
159plasma membrane repair (GO:0001778)2.59761006
160molting cycle process (GO:0022404)2.57488750
161hair cycle process (GO:0022405)2.57488750
162Golgi transport vesicle coating (GO:0048200)2.53494276
163COPI coating of Golgi vesicle (GO:0048205)2.53494276
164adherens junction organization (GO:0034332)2.50149734
165desmosome organization (GO:0002934)14.1066954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.61713839
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.76523284
3* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.99673609
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.72571600
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.70257016
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.68007616
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42283966
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11954520
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.08808537
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08704179
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08704179
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04876808
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03258926
14TP63_17297297_ChIP-ChIP_HaCaT_Human15.9302323
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91528031
16AR_21572438_ChIP-Seq_LNCaP_Human1.68653165
17AR_21909140_ChIP-Seq_LNCAP_Human1.67467028
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.65903566
19CJUN_26792858_Chip-Seq_BT549_Human1.65714003
20SOX2_20726797_ChIP-Seq_SW620_Human1.64917763
21ZNF263_19887448_ChIP-Seq_K562_Human1.57035305
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55711371
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51870281
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32740538
25TP53_18474530_ChIP-ChIP_U2OS_Human1.31958773
26TP63_23658742_ChIP-Seq_EP156T_Human1.29707473
27EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28795981
28KLF5_25053715_ChIP-Seq_YYC3_Human1.26065479
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23238724
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.22206193
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20586417
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.18851662
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.16984328
34* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16437929
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.13509957
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09529135
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09465625
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08851166
39RXR_22108803_ChIP-Seq_LS180_Human1.08670468
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08030283
41TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07198326
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04077854
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03405613
44GATA4_25053715_ChIP-Seq_YYC3_Human1.01885604
45* TP63_22573176_ChIP-Seq_HFKS_Human1.01235639
46ATF3_27146783_Chip-Seq_COLON_Human1.00435655
47RACK7_27058665_Chip-Seq_MCF-7_Human1.00033075
48GATA3_24758297_ChIP-Seq_MCF-7_Human0.99949148
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99137771
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97895558
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97454603
52UBF1/2_26484160_Chip-Seq_HMECs_Human0.96357542
53GATA1_22025678_ChIP-Seq_K562_Human0.93384590
54* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93052735
55EED_16625203_ChIP-ChIP_MESCs_Mouse0.92423289
56JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92023536
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91215803
58AHR_22903824_ChIP-Seq_MCF-7_Human0.90595202
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90576090
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88280432
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86261582
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85430121
63NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85271243
64EZH2_27304074_Chip-Seq_ESCs_Mouse0.84517220
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84338714
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84268201
67* PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82979273
68BCAT_22108803_ChIP-Seq_LS180_Human0.82786853
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82705202
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82705202
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82608045
72TP53_16413492_ChIP-PET_HCT116_Human0.82142117
73CLOCK_20551151_ChIP-Seq_293T_Human0.82068435
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81928557
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81749973
76GATA6_25053715_ChIP-Seq_YYC3_Human0.81702970
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80797747
78ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80772219
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80590562
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80420603
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.79888891
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79763067
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.79186801
84SMC4_20622854_ChIP-Seq_HELA_Human0.79036374
85* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78961114
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77163451
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76908475
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76703504
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75919921
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75290748
91ELF5_23300383_ChIP-Seq_T47D_Human0.74972953
92BRD4_25478319_ChIP-Seq_HGPS_Human0.73428819
93TP53_22127205_ChIP-Seq_IMR90_Human0.73181445
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.72758813
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.72338019
96CHD1_26751641_Chip-Seq_LNCaP_Human0.71937511
97SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71354269
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.71287359
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.71006052
100TCF4_22108803_ChIP-Seq_LS180_Human0.70574595
101SUZ12_27294783_Chip-Seq_ESCs_Mouse0.70255910
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69993147
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.69796725
104ESR1_20079471_ChIP-ChIP_T-47D_Human0.69439589
105EOMES_21245162_ChIP-Seq_HESCs_Human0.69412051
106TBX20_22080862_ChIP-Seq_HEART_Mouse0.68822988
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.68822988
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.68609770
109LXR_22292898_ChIP-Seq_THP-1_Human0.67651988
110GATA6_21074721_ChIP-Seq_CACO-2_Human0.66929865
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.65133442
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.64386287
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.64365161
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.64099819
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.63644547
116RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63395788
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.63086576
118NANOG_18692474_ChIP-Seq_MEFs_Mouse0.62850481
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62576919
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.61418699
121NELFA_20434984_ChIP-Seq_ESCs_Mouse0.60899512
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60873302
123SA1_27219007_Chip-Seq_ERYTHROID_Human0.60647082
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.60373472
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.59857600
126CEBPB_22108803_ChIP-Seq_LS180_Human0.59730259
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.59439037
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.58959914
129RNF2_18974828_ChIP-Seq_MESCs_Mouse0.58628532
130EZH2_18974828_ChIP-Seq_MESCs_Mouse0.58628532
131EGR1_19032775_ChIP-ChIP_M12_Human0.58588685
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.58189557
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.57998336
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.57829903
135RBPJ_21746931_ChIP-Seq_IB4_Human0.57641828
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56952560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.51271403
2MP0005275_abnormal_skin_tensile5.19971588
3MP0010234_abnormal_vibrissa_follicle4.94863633
4MP0003941_abnormal_skin_development4.45106882
5MP0005501_abnormal_skin_physiology4.11035008
6MP0004381_abnormal_hair_follicle3.95831740
7MP0002060_abnormal_skin_morphology3.64708621
8MP0001216_abnormal_epidermal_layer3.28099358
9MP0002254_reproductive_system_inflammat3.24984711
10MP0000579_abnormal_nail_morphology3.16937240
11MP0000383_abnormal_hair_follicle3.07214313
12MP0002098_abnormal_vibrissa_morphology3.03444896
13MP0003453_abnormal_keratinocyte_physiol2.97455764
14MP0003705_abnormal_hypodermis_morpholog2.89732733
15MP0010678_abnormal_skin_adnexa2.89706640
16MP0010771_integument_phenotype2.80793300
17MP0000647_abnormal_sebaceous_gland2.50955970
18MP0000377_abnormal_hair_follicle2.41843314
19MP0000467_abnormal_esophagus_morphology2.39450822
20MP0009379_abnormal_foot_pigmentation2.22998749
21MP0004264_abnormal_extraembryonic_tissu2.20802637
22MP0000762_abnormal_tongue_morphology2.20714200
23MP0003566_abnormal_cell_adhesion2.16297350
24MP0000427_abnormal_hair_cycle2.15647635
25MP0001346_abnormal_lacrimal_gland2.14524483
26MP0004947_skin_inflammation1.84742385
27MP0000566_synostosis1.81308668
28MP0002009_preneoplasia1.69177441
29MP0010352_gastrointestinal_tract_polyps1.68409755
30MP0009384_cardiac_valve_regurgitation1.67366651
31MP0005257_abnormal_intraocular_pressure1.66820319
32MP0000678_abnormal_parathyroid_gland1.58239208
33MP0004185_abnormal_adipocyte_glucose1.57031168
34MP0001191_abnormal_skin_condition1.53578121
35MP0009931_abnormal_skin_appearance1.53042046
36MP0002282_abnormal_trachea_morphology1.52873742
37MP0001243_abnormal_dermal_layer1.47927122
38MP0003011_delayed_dark_adaptation1.40612729
39MP0003806_abnormal_nucleotide_metabolis1.38512070
40MP0005023_abnormal_wound_healing1.36776021
41MP0005451_abnormal_body_composition1.36007489
42MP0009780_abnormal_chondrocyte_physiolo1.33702429
43MP0003191_abnormal_cellular_cholesterol1.28264681
44MP0000367_abnormal_coat/_hair1.27214470
45MP0001851_eye_inflammation1.26352397
46MP0010030_abnormal_orbit_morphology1.25819954
47MP0000537_abnormal_urethra_morphology1.22256338
48MP0002877_abnormal_melanocyte_morpholog1.20768843
49MP0009250_abnormal_appendicular_skeleto1.19853961
50MP0008004_abnormal_stomach_pH1.18205810
51MP0001340_abnormal_eyelid_morphology1.17276003
52MP0002234_abnormal_pharynx_morphology1.09548070
53MP0005508_abnormal_skeleton_morphology1.07885719
54MP0000516_abnormal_urinary_system1.07062644
55MP0005367_renal/urinary_system_phenotyp1.07062644
56MP0008438_abnormal_cutaneous_collagen1.06801678
57MP0002249_abnormal_larynx_morphology1.06101843
58MP0009053_abnormal_anal_canal1.05847590
59MP0008260_abnormal_autophagy1.01667603
60MP0004272_abnormal_basement_membrane1.01396088
61MP0003315_abnormal_perineum_morphology0.97592112
62MP0000465_gastrointestinal_hemorrhage0.93140922
63MP0003136_yellow_coat_color0.91169199
64MP0003755_abnormal_palate_morphology0.90681670
65MP0005360_urolithiasis0.88574561
66MP0001542_abnormal_bone_strength0.87649487
67MP0000163_abnormal_cartilage_morphology0.85930621
68MP0003878_abnormal_ear_physiology0.85077862
69MP0005377_hearing/vestibular/ear_phenot0.85077862
70MP0000627_abnormal_mammary_gland0.79840341
71MP0000858_altered_metastatic_potential0.79523224
72MP0005390_skeleton_phenotype0.78809356
73MP0003436_decreased_susceptibility_to0.74977160
74MP0005083_abnormal_biliary_tract0.74964801
75MP0002233_abnormal_nose_morphology0.73519614
76MP0001849_ear_inflammation0.73494900
77MP0000003_abnormal_adipose_tissue0.72263400
78MP0001661_extended_life_span0.72261073
79MP0003786_premature_aging0.72253308
80MP0000538_abnormal_urinary_bladder0.71977875
81MP0005076_abnormal_cell_differentiation0.71579474
82MP0002896_abnormal_bone_mineralization0.70575317
83MP0008789_abnormal_olfactory_epithelium0.70303473
84MP0005503_abnormal_tendon_morphology0.70254450
85MP0002933_joint_inflammation0.68053864
86MP0005197_abnormal_uvea_morphology0.65800287
87MP0001533_abnormal_skeleton_physiology0.64354362
88MP0004782_abnormal_surfactant_physiolog0.63455541
89MP0003385_abnormal_body_wall0.63078786
90MP0002111_abnormal_tail_morphology0.62830742
91MP0002115_abnormal_skeleton_extremities0.62544023
92MP0004957_abnormal_blastocyst_morpholog0.61790211
93MP0004019_abnormal_vitamin_homeostasis0.60640849
94MP0002177_abnormal_outer_ear0.60606427
95MP0010368_abnormal_lymphatic_system0.60162122
96MP0003091_abnormal_cell_migration0.58627114
97MP0002697_abnormal_eye_size0.56211603
98MP0003950_abnormal_plasma_membrane0.54929811
99MP0006054_spinal_hemorrhage0.53853452
100MP0002109_abnormal_limb_morphology0.53428533
101MP0002006_tumorigenesis0.53297338
102MP0005193_abnormal_anterior_eye0.53067512
103MP0005187_abnormal_penis_morphology0.52299723
104MP0000432_abnormal_head_morphology0.51890125
105MP0008932_abnormal_embryonic_tissue0.51380949
106MP0004233_abnormal_muscle_weight0.50595091
107MP0006138_congestive_heart_failure0.50448028
108MP0004134_abnormal_chest_morphology0.49570097
109MP0003638_abnormal_response/metabolism_0.49395323
110MP0001784_abnormal_fluid_regulation0.47905378
111MP0000613_abnormal_salivary_gland0.47705517
112MP0005330_cardiomyopathy0.46438724
113MP0000013_abnormal_adipose_tissue0.45655308
114MP0000462_abnormal_digestive_system0.45429841
115MP0002166_altered_tumor_susceptibility0.44609997
116MP0002095_abnormal_skin_pigmentation0.44350839
117MP0001958_emphysema0.44185866
118MP0003045_fibrosis0.42967634
119MP0005623_abnormal_meninges_morphology0.42257936
120MP0003795_abnormal_bone_structure0.42182301
121MP0005248_abnormal_Harderian_gland0.41296273
122MP0009697_abnormal_copulation0.41283807
123MP0005666_abnormal_adipose_tissue0.41272690
124MP0001299_abnormal_eye_distance/0.41264226
125MP0000049_abnormal_middle_ear0.41083746
126MP0000733_abnormal_muscle_development0.40984883
127MP0005499_abnormal_olfactory_system0.40911981
128MP0005394_taste/olfaction_phenotype0.40911981
129MP0002113_abnormal_skeleton_development0.40280778
130MP0000750_abnormal_muscle_regeneration0.40192072
131MP0002086_abnormal_extraembryonic_tissu0.40054926
132MP0002277_abnormal_respiratory_mucosa0.39903812
133MP0003693_abnormal_embryo_hatching0.39296808
134MP0005621_abnormal_cell_physiology0.37347545
135MP0003935_abnormal_craniofacial_develop0.36383977
136MP0005409_darkened_coat_color0.35482070
137MP0005075_abnormal_melanosome_morpholog0.35443306

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)5.86680545
2Plantar hyperkeratosis (HP:0007556)5.78527605
3Hypotrichosis (HP:0001006)5.70242356
4Woolly hair (HP:0002224)5.22133693
5Parakeratosis (HP:0001036)5.15690213
6Onycholysis (HP:0001806)5.10795540
7Right ventricular cardiomyopathy (HP:0011663)4.99664155
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.97490491
9Palmoplantar hyperkeratosis (HP:0000972)4.93426998
10Lip pit (HP:0100267)4.70751582
11Congenital ichthyosiform erythroderma (HP:0007431)4.67766143
12Palmar hyperkeratosis (HP:0010765)4.61504211
13Erythema (HP:0010783)4.43290913
14Milia (HP:0001056)4.22228123
15Abnormality of nail color (HP:0100643)4.07114430
16Increased IgE level (HP:0003212)4.00199090
17Abnormality of the axillary hair (HP:0100134)3.78253610
18Abnormality of secondary sexual hair (HP:0009888)3.78253610
19Selective tooth agenesis (HP:0001592)3.77661236
20Natal tooth (HP:0000695)3.76490553
21Abnormal blistering of the skin (HP:0008066)3.49465670
22Oral leukoplakia (HP:0002745)3.48912431
23Erythroderma (HP:0001019)3.44118470
24Distal lower limb muscle weakness (HP:0009053)3.42458540
25Dry hair (HP:0011359)3.35081149
26Sparse scalp hair (HP:0002209)3.34393708
27Atrophic scars (HP:0001075)3.32107056
28Ankyloglossia (HP:0010296)3.20885656
29Thick nail (HP:0001805)3.16811358
30Epiphyseal dysplasia (HP:0002656)3.16479559
31Abnormality of cells of the erythroid lineage (HP:0012130)3.13641140
32Nail dystrophy (HP:0008404)3.06385936
33Advanced eruption of teeth (HP:0006288)3.05361883
34Sparse eyelashes (HP:0000653)3.05008206
35Acanthosis nigricans (HP:0000956)3.04628688
36Absent eyelashes (HP:0000561)3.03441651
37Abnormal hemoglobin (HP:0011902)3.00819322
38Pili torti (HP:0003777)3.00578780
39Popliteal pterygium (HP:0009756)2.98904455
40Abnormality of the salivary glands (HP:0010286)2.89211497
41Abnormality of placental membranes (HP:0011409)2.89140589
42Amniotic constriction ring (HP:0009775)2.89140589
43Congenital, generalized hypertrichosis (HP:0004540)2.78353962
44Conjunctival hamartoma (HP:0100780)2.68974937
45Abnormality of the 2nd finger (HP:0004100)2.68917350
46Hypohidrosis (HP:0000966)2.64944270
47Concave nail (HP:0001598)2.63951489
48Neonatal short-limb short stature (HP:0008921)2.63265360
49Anonychia (HP:0001798)2.60911091
50Abnormality of the distal phalanges of the toes (HP:0010182)2.60427216
51Reticulocytopenia (HP:0001896)2.57358303
52Pterygium (HP:0001059)2.53419407
53Abnormality of the neuromuscular junction (HP:0003398)2.52333950
54Fatigable weakness (HP:0003473)2.52333950
55Down-sloping shoulders (HP:0200021)2.52238169
56Hyporeflexia of lower limbs (HP:0002600)2.49069271
57Abnormality of oral frenula (HP:0000190)2.49032282
58Abnormal number of erythroid precursors (HP:0012131)2.48937149
59Alopecia of scalp (HP:0002293)2.45596335
60Irregular epiphyses (HP:0010582)2.42937327
61Delayed epiphyseal ossification (HP:0002663)2.40586115
62Curly hair (HP:0002212)2.39771413
63Oligodontia (HP:0000677)2.39583152
64Aplasia involving bones of the upper limbs (HP:0009823)2.38969969
65Aplasia of the phalanges of the hand (HP:0009802)2.38969969
66Aplasia involving bones of the extremities (HP:0009825)2.38969969
67Ectropion (HP:0000656)2.38115796
68Abnormality of the phalanges of the 2nd finger (HP:0009541)2.38059869
69Vitreoretinal degeneration (HP:0000655)2.37859230
70Fragile skin (HP:0001030)2.35245103
71Ventricular tachycardia (HP:0004756)2.34674265
72Carious teeth (HP:0000670)2.33700779
73Blepharitis (HP:0000498)2.33024931
74Anhidrosis (HP:0000970)2.31219784
75Premature rupture of membranes (HP:0001788)2.30670555
76Ridged nail (HP:0001807)2.28840421
77Corneal erosion (HP:0200020)2.27734501
78Enlarged epiphyses (HP:0010580)2.25551641
79Palmoplantar keratoderma (HP:0000982)2.24431118
80Severe Myopia (HP:0011003)2.22523394
81Aplasia cutis congenita (HP:0001057)2.21151690
82Cheilitis (HP:0100825)2.20878506
83Abnormal vertebral ossification (HP:0100569)2.18800578
84Cupped ribs (HP:0000887)2.17962903
85Abnormality of the phalanges of the 5th finger (HP:0004213)2.16833485
86Hyperhidrosis (HP:0000975)2.12818044
87Amelogenesis imperfecta (HP:0000705)2.09784547
88Increased connective tissue (HP:0009025)2.09485856
89Pruritus (HP:0000989)2.08784697
90Genu varum (HP:0002970)2.08197350
91Abnormality of the dental root (HP:0006486)2.06589026
92Taurodontia (HP:0000679)2.06589026
93Abnormality of permanent molar morphology (HP:0011071)2.06589026
94Hypoplastic ischia (HP:0003175)2.06103650
95Poikiloderma (HP:0001029)2.05206229
96Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.04227611
97Macrocytic anemia (HP:0001972)2.02504289
98Hypoplastic labia majora (HP:0000059)2.00997836
99Short nail (HP:0001799)1.97415330
100Labial hypoplasia (HP:0000066)1.97158037
101Abnormality of the middle phalanges of the toes (HP:0010183)1.95478269
102Abnormality of the fingernails (HP:0001231)1.94761151
103Breast hypoplasia (HP:0003187)1.92770277
104Abnormal tarsal ossification (HP:0008369)1.92456044
105Abnormality of molar morphology (HP:0011070)1.89520009
106Abnormality of molar (HP:0011077)1.89520009
107Hypoplastic female external genitalia (HP:0012815)1.88178686
108Flat acetabular roof (HP:0003180)1.86981047
109Hypodontia (HP:0000668)1.86703863
110Multifactorial inheritance (HP:0001426)1.85017887
111Xerostomia (HP:0000217)1.84622660
112Abnormality of the middle phalanges of the hand (HP:0009833)1.83927239
113Abnormality of the labia majora (HP:0012881)1.81958329
114Corneal dystrophy (HP:0001131)1.81795634
115Ureteral duplication (HP:0000073)1.81507240
116Hypoplasia of the uterus (HP:0000013)1.81285642
117Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.80184807
118Gangrene (HP:0100758)1.80141840
119Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79860643
120Reduced subcutaneous adipose tissue (HP:0003758)1.79840069
121Hypoplasia of dental enamel (HP:0006297)1.79452339
122Nasolacrimal duct obstruction (HP:0000579)1.79090518
123Abnormality of the dental pulp (HP:0006479)1.78465880
124Vascular calcification (HP:0004934)1.78221635
125Absent hair (HP:0002298)1.77677579
126Abnormality of the ischium (HP:0003174)1.77253954
127Brittle hair (HP:0002299)1.76039999
128Dehydration (HP:0001944)1.73773431
129Pallor (HP:0000980)1.73342648
130Abnormal hair laboratory examination (HP:0003328)1.72602585
131Septate vagina (HP:0001153)1.72062055
132Squamous cell carcinoma (HP:0002860)1.71992883
133Metaphyseal irregularity (HP:0003025)1.70638355
134Coxa vara (HP:0002812)1.69761569
135Conical tooth (HP:0000698)1.68645118
136Abnormality of the gastric mucosa (HP:0004295)1.68047553
137Trismus (HP:0000211)1.66158895
138Duplicated collecting system (HP:0000081)1.64824064
139Follicular hyperkeratosis (HP:0007502)1.64338638
140Upper limb muscle weakness (HP:0003484)1.64116912
141Split foot (HP:0001839)1.64036963
142Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64031306
143Vertebral hypoplasia (HP:0008417)1.64031306
144Stenosis of the external auditory canal (HP:0000402)1.63837746
145Cardiovascular calcification (HP:0011915)1.58811572
146Pustule (HP:0200039)1.58727705
147Skin ulcer (HP:0200042)1.55102804
148Entropion (HP:0000621)1.52023416
149Abnormality of the labia (HP:0000058)1.51032420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K35.35617890
2MST1R5.11773569
3MST44.07552597
4MAPKAPK33.81100036
5EPHB23.25540539
6TRPM73.05421516
7FER3.01973946
8MAP3K122.97615536
9PIM22.78024669
10MAP3K22.60828008
11STK242.59357594
12ERBB32.55611403
13ERN12.49083362
14ARAF2.37926340
15MAP3K92.32343256
16RPS6KB22.22647829
17FLT32.17901973
18MET2.00541251
19LRRK21.97381548
20NTRK11.94217249
21PAK41.92598213
22TESK11.84478138
23LATS11.80240953
24EPHA21.74018909
25STK101.64593903
26DDR21.52282823
27PIK3CG1.46413871
28BCR1.44441166
29NME21.44084472
30MAP3K61.43605836
31MYLK1.42713405
32MAPKAPK51.42090232
33BUB11.31561319
34TGFBR21.19349668
35LIMK11.19252744
36PDGFRA1.18404784
37EEF2K1.10641042
38SIK11.06411266
39STK381.04227661
40LMTK21.03770703
41EPHA31.03588575
42TAOK11.01072073
43STK38L1.00276285
44PTK60.98527991
45MOS0.97506458
46LATS20.93535384
47DYRK1B0.92839951
48PBK0.92410396
49KSR20.90265546
50ABL20.88191844
51NEK10.87367469
52MAP2K10.86870607
53RAF10.85965928
54CDK60.85650768
55GRK70.85110020
56MAPK150.84912279
57FGFR20.82982548
58MAP3K110.80958134
59RPS6KA40.78260487
60BMPR1B0.76205772
61SMG10.75991746
62GRK10.74861974
63MAP2K20.73468947
64MAPKAPK20.72141512
65CDK30.71695130
66MAP2K60.70682515
67TTN0.68555121
68MAP3K10.67019632
69PTK2B0.66384758
70FGFR40.65073335
71NME10.65046951
72MAP3K140.62650638
73PRKD10.61245498
74IKBKB0.60883596
75KSR10.59743661
76BLK0.59423369
77TAOK20.58761371
78EIF2AK10.58056454
79ILK0.57535305
80ROCK10.55812382
81CDK120.53660389
82EIF2AK20.53207576
83PTK20.52897028
84SIK30.51876863
85ADRBK10.51467050
86TGFBR10.51460541
87PAK30.51431508
88STK30.49163474
89MAP3K80.48902929
90FRK0.46803881
91MAP3K50.46312740
92CAMK2G0.44771296
93BRAF0.43493809
94FGFR30.43241126
95PRKCE0.42931855
96TRIB30.42285774
97TYK20.42190870
98TNK20.41359029
99NTRK20.40485806
100BMX0.40006047
101PDGFRB0.38568026
102PRKCI0.36123877
103PDK20.36075683
104ITK0.35810808
105FGFR10.35376763
106BMPR20.35113625
107DAPK10.33122065
108ABL10.32845999
109MAP2K30.31984345
110PAK20.31288498
111IRAK30.30915903
112MTOR0.30909864
113AURKA0.30147570
114MAP3K130.29844879
115RIPK10.29777838
116MAPK40.29339384
117GSK3A0.28838232
118ERBB20.28260413
119HIPK20.27560409
120TESK20.26984866
121CDK80.26068117
122ERBB40.25944743
123WEE10.25527051
124EPHB10.24787908
125IGF1R0.24718476
126RPS6KA10.24174093
127ZAP700.23859834
128RPS6KA20.23292210
129PRKD20.22799126
130DYRK1A0.22243645
131MAPK120.21842746
132GRK50.21023611
133SRC0.20586983
134EIF2AK30.20120686
135AURKB0.20019051
136CDK90.19993257
137ROCK20.19987570
138MAPK70.19761710
139MUSK0.19614022
140SCYL20.19519232
141PIK3CA0.19215249
142JAK30.19026467
143PRKG20.19018314
144TTK0.17953890
145NEK60.16798591
146CSNK1A1L0.16546909
147RET0.16051454
148PAK10.14065402

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.15296319
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.31016596
3Sphingolipid metabolism_Homo sapiens_hsa006003.61302005
4Proteasome_Homo sapiens_hsa030503.23450497
5ECM-receptor interaction_Homo sapiens_hsa045122.64583891
6Fatty acid elongation_Homo sapiens_hsa000622.52246241
7Arachidonic acid metabolism_Homo sapiens_hsa005902.47951970
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47656947
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.46502470
10Linoleic acid metabolism_Homo sapiens_hsa005912.34390940
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29675909
12Phenylalanine metabolism_Homo sapiens_hsa003602.27192580
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.22518771
14Retinol metabolism_Homo sapiens_hsa008302.09595688
15Chemical carcinogenesis_Homo sapiens_hsa052042.03276931
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02497909
17Basal cell carcinoma_Homo sapiens_hsa052172.01002662
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.86472130
19Galactose metabolism_Homo sapiens_hsa000521.83706086
20Histidine metabolism_Homo sapiens_hsa003401.75751077
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60688572
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55035640
23Pentose phosphate pathway_Homo sapiens_hsa000301.54486482
24Bladder cancer_Homo sapiens_hsa052191.53350725
25Hippo signaling pathway_Homo sapiens_hsa043901.50954375
26Adherens junction_Homo sapiens_hsa045201.46649095
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45968749
28TGF-beta signaling pathway_Homo sapiens_hsa043501.44118638
29Proteoglycans in cancer_Homo sapiens_hsa052051.40563900
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.36712248
31Protein digestion and absorption_Homo sapiens_hsa049741.36305352
32Shigellosis_Homo sapiens_hsa051311.32546958
33p53 signaling pathway_Homo sapiens_hsa041151.27201193
34Fructose and mannose metabolism_Homo sapiens_hsa000511.25776291
35Tyrosine metabolism_Homo sapiens_hsa003501.25175402
36Hedgehog signaling pathway_Homo sapiens_hsa043401.24944566
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.23858821
38Glutathione metabolism_Homo sapiens_hsa004801.21918619
39N-Glycan biosynthesis_Homo sapiens_hsa005101.17732865
40Ether lipid metabolism_Homo sapiens_hsa005651.16808263
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16497604
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16085649
43Axon guidance_Homo sapiens_hsa043601.14736408
44Folate biosynthesis_Homo sapiens_hsa007901.14711786
45Other glycan degradation_Homo sapiens_hsa005111.09249641
46Tight junction_Homo sapiens_hsa045301.06537337
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.04083938
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00396268
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99939692
50Melanogenesis_Homo sapiens_hsa049160.97946530
51Pancreatic cancer_Homo sapiens_hsa052120.97922421
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.97850473
53VEGF signaling pathway_Homo sapiens_hsa043700.93764446
54Endocytosis_Homo sapiens_hsa041440.93326085
55Amoebiasis_Homo sapiens_hsa051460.93011170
56Chronic myeloid leukemia_Homo sapiens_hsa052200.92821459
57Steroid biosynthesis_Homo sapiens_hsa001000.89640149
58MicroRNAs in cancer_Homo sapiens_hsa052060.89411045
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88521906
60Focal adhesion_Homo sapiens_hsa045100.88042108
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83967504
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83482756
63Arginine biosynthesis_Homo sapiens_hsa002200.83389692
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81522963
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80880912
66Ovarian steroidogenesis_Homo sapiens_hsa049130.80426048
67Vibrio cholerae infection_Homo sapiens_hsa051100.79196345
68Thyroid cancer_Homo sapiens_hsa052160.79075149
69Biosynthesis of amino acids_Homo sapiens_hsa012300.78712284
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78028924
71Nucleotide excision repair_Homo sapiens_hsa034200.74842902
72Caffeine metabolism_Homo sapiens_hsa002320.74196371
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74095166
74Wnt signaling pathway_Homo sapiens_hsa043100.73577103
75beta-Alanine metabolism_Homo sapiens_hsa004100.72804328
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71377226
77GnRH signaling pathway_Homo sapiens_hsa049120.70723196
78Mineral absorption_Homo sapiens_hsa049780.70286029
79Renal cell carcinoma_Homo sapiens_hsa052110.69251702
80Malaria_Homo sapiens_hsa051440.68827304
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.66999143
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64386749
83Pancreatic secretion_Homo sapiens_hsa049720.62916714
84Melanoma_Homo sapiens_hsa052180.62843929
85Small cell lung cancer_Homo sapiens_hsa052220.62376325
86Ras signaling pathway_Homo sapiens_hsa040140.62269382
87Fatty acid biosynthesis_Homo sapiens_hsa000610.62086059
88Glioma_Homo sapiens_hsa052140.60640093
89Renin secretion_Homo sapiens_hsa049240.60367209
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60090608
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.59377434
92Pertussis_Homo sapiens_hsa051330.58451021
93Pyruvate metabolism_Homo sapiens_hsa006200.58362056
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58220967
95Carbon metabolism_Homo sapiens_hsa012000.58154226
96Pyrimidine metabolism_Homo sapiens_hsa002400.55929861
97Toxoplasmosis_Homo sapiens_hsa051450.55881261
98Phototransduction_Homo sapiens_hsa047440.55252458
99Insulin signaling pathway_Homo sapiens_hsa049100.54451838
100Platelet activation_Homo sapiens_hsa046110.54345674
101Rap1 signaling pathway_Homo sapiens_hsa040150.52456931
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.51636332
103Notch signaling pathway_Homo sapiens_hsa043300.51379305
104Serotonergic synapse_Homo sapiens_hsa047260.50631805
105Sulfur metabolism_Homo sapiens_hsa009200.50417852
106Cell cycle_Homo sapiens_hsa041100.50399687
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50197552
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49992748
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49470636
110Sulfur relay system_Homo sapiens_hsa041220.47965186
111Starch and sucrose metabolism_Homo sapiens_hsa005000.47193175
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46854691
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46692242
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45550385
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45397381
116Vitamin B6 metabolism_Homo sapiens_hsa007500.43937896
117Prion diseases_Homo sapiens_hsa050200.43714577
118Pathways in cancer_Homo sapiens_hsa052000.43314891
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42193731
120Hematopoietic cell lineage_Homo sapiens_hsa046400.41296501
121Staphylococcus aureus infection_Homo sapiens_hsa051500.40913393
122Hepatitis C_Homo sapiens_hsa051600.40898970
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40794590
124Fatty acid metabolism_Homo sapiens_hsa012120.38725006
125Fatty acid degradation_Homo sapiens_hsa000710.38015465
126Fat digestion and absorption_Homo sapiens_hsa049750.36812892
127Lysosome_Homo sapiens_hsa041420.35491155
128Inositol phosphate metabolism_Homo sapiens_hsa005620.35308634
129Long-term depression_Homo sapiens_hsa047300.34927629
130TNF signaling pathway_Homo sapiens_hsa046680.34015504
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.33956501
132PPAR signaling pathway_Homo sapiens_hsa033200.32724159
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.30564641
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30087425
135ErbB signaling pathway_Homo sapiens_hsa040120.29851876
136Salmonella infection_Homo sapiens_hsa051320.29550140
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29248914
138HTLV-I infection_Homo sapiens_hsa051660.28976238
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27543652
140Dilated cardiomyopathy_Homo sapiens_hsa054140.26812427
141Prostate cancer_Homo sapiens_hsa052150.23660416
142Salivary secretion_Homo sapiens_hsa049700.23572917
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22755425
144Apoptosis_Homo sapiens_hsa042100.21787902
145Graft-versus-host disease_Homo sapiens_hsa053320.21715539
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20960098

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