ANXA8L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.54365805
2keratinization (GO:0031424)9.04578508
3keratinocyte proliferation (GO:0043616)8.16605123
4negative regulation of keratinocyte proliferation (GO:0010839)7.40950608
5molting cycle (GO:0042303)7.38255732
6hair cycle (GO:0042633)7.38255732
7keratinocyte differentiation (GO:0030216)6.57046083
8cell-substrate junction assembly (GO:0007044)6.46998732
9multicellular organismal water homeostasis (GO:0050891)6.33004091
10intermediate filament organization (GO:0045109)6.26604027
11keratinocyte development (GO:0003334)6.24025046
12epidermis development (GO:0008544)6.07721855
13regulation of keratinocyte proliferation (GO:0010837)5.62128579
14regulation of phospholipase A2 activity (GO:0032429)5.41956468
15water homeostasis (GO:0030104)5.28681521
16peptide cross-linking (GO:0018149)5.17246123
17epidermal cell differentiation (GO:0009913)5.12369715
18positive regulation of epidermal cell differentiation (GO:0045606)4.98288395
19positive regulation of epidermis development (GO:0045684)4.84317197
20gap junction assembly (GO:0016264)4.79322275
21regulation of transforming growth factor beta2 production (GO:0032909)4.75687995
22surfactant homeostasis (GO:0043129)4.71388411
23polarized epithelial cell differentiation (GO:0030859)4.57886698
24skin morphogenesis (GO:0043589)4.40946673
25intermediate filament cytoskeleton organization (GO:0045104)4.39447579
26intermediate filament-based process (GO:0045103)4.25641228
27establishment of tissue polarity (GO:0007164)4.20038006
28establishment of planar polarity (GO:0001736)4.20038006
29positive regulation of keratinocyte differentiation (GO:0045618)4.08513878
30dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.05270668
31regulation of hair follicle development (GO:0051797)4.04545693
32cell adhesion mediated by integrin (GO:0033627)3.93278005
33chemical homeostasis within a tissue (GO:0048875)3.89990103
34positive regulation of hair cycle (GO:0042635)3.81694241
35positive regulation of hair follicle development (GO:0051798)3.81694241
36lateral sprouting from an epithelium (GO:0060601)3.80578759
37regulation of keratinocyte differentiation (GO:0045616)3.78850820
38regulation of epidermis development (GO:0045682)3.70166819
39ectoderm development (GO:0007398)3.57775217
40membrane raft organization (GO:0031579)3.56529454
41negative regulation of chondrocyte differentiation (GO:0032331)3.55551795
42negative regulation of lipase activity (GO:0060192)3.41228810
43epithelial cell differentiation involved in prostate gland development (GO:0060742)3.37517775
44intestinal epithelial cell development (GO:0060576)3.35553413
45regulation of cardioblast differentiation (GO:0051890)3.24634500
46skin development (GO:0043588)3.24084675
47morphogenesis of embryonic epithelium (GO:0016331)3.22633628
48regulation of hair cycle (GO:0042634)3.20832966
49negative regulation of stem cell proliferation (GO:2000647)3.20238162
50cell junction assembly (GO:0034329)3.18258187
51regulation of epidermal cell differentiation (GO:0045604)3.16334035
52ventricular cardiac muscle cell action potential (GO:0086005)3.13973255
53plasma membrane repair (GO:0001778)3.09679512
54epithelium development (GO:0060429)3.06612212
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.05834622
56cell junction organization (GO:0034330)3.05387874
57epithelial cell-cell adhesion (GO:0090136)3.03332860
58endosome organization (GO:0007032)3.03222396
59mesodermal cell differentiation (GO:0048333)3.01853620
60hypotonic response (GO:0006971)3.01511569
61hair follicle morphogenesis (GO:0031069)2.99070741
62membrane budding (GO:0006900)2.97906423
63G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.97270095
64protein autoprocessing (GO:0016540)2.96341387
65atrioventricular valve morphogenesis (GO:0003181)2.91717868
66regulation of G0 to G1 transition (GO:0070316)2.83365309
67cell-substrate adherens junction assembly (GO:0007045)2.82971607
68focal adhesion assembly (GO:0048041)2.82971607
69negative regulation of cartilage development (GO:0061037)2.82674684
70molting cycle process (GO:0022404)2.76248906
71hair cycle process (GO:0022405)2.76248906
72cell-cell junction assembly (GO:0007043)2.74674623
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74045056
74regulation of hippo signaling (GO:0035330)2.72871615
75regulation of transforming growth factor beta production (GO:0071634)2.69974391
76negative regulation of epidermis development (GO:0045683)2.65983849
77regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.64955783
78cardiac right ventricle morphogenesis (GO:0003215)2.64631216
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.62499822
80regulation of transforming growth factor beta1 production (GO:0032908)2.61513174
81gland morphogenesis (GO:0022612)2.58906002
82regulation of heart rate by cardiac conduction (GO:0086091)2.57804971
83sphingoid metabolic process (GO:0046519)2.57621024
84protein localization to endosome (GO:0036010)2.52738957
85regulation of metalloenzyme activity (GO:0048552)2.48468823
86endodermal cell differentiation (GO:0035987)2.47858126
87sphingosine metabolic process (GO:0006670)2.47600417
88cell differentiation involved in embryonic placenta development (GO:0060706)2.46563033
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.46067871
90negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.45919703
91positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.45155227
92mammary gland epithelial cell proliferation (GO:0033598)2.45045411
93regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.44644967
94wound healing (GO:0042060)2.41246713
95negative regulation of cell fate specification (GO:0009996)2.40584823
96natural killer cell mediated cytotoxicity (GO:0042267)2.40532989
97hemidesmosome assembly (GO:0031581)15.9428577
98desmosome organization (GO:0002934)14.7934884
99establishment of skin barrier (GO:0061436)10.2612575
100bundle of His cell to Purkinje myocyte communication (GO:0086069)10.0117623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.65235824
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human5.40284802
3SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.43101189
4SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.43101189
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.28091473
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72143161
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.42644262
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42164737
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36545518
10ZNF263_19887448_ChIP-Seq_K562_Human2.33090542
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.26551194
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.24312827
13SOX9_24532713_ChIP-Seq_HFSC_Mouse2.24026988
14KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.12183215
15TP63_17297297_ChIP-ChIP_HaCaT_Human15.1786878
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.95716914
17KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.90078307
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86055641
19TP63_23658742_ChIP-Seq_EP156T_Human1.79899798
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.78133558
21SOX2_20726797_ChIP-Seq_SW620_Human1.76257596
22* ATF3_27146783_Chip-Seq_COLON_Human1.70133647
23ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.66655984
24UBF1/2_26484160_Chip-Seq_HMECs_Human1.65225369
25FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62031211
26CJUN_26792858_Chip-Seq_BT549_Human1.56246164
27* TP63_22573176_ChIP-Seq_HFKS_Human1.55204396
28RACK7_27058665_Chip-Seq_MCF-7_Human1.54355601
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51768886
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50672800
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44994820
32KLF5_25053715_ChIP-Seq_YYC3_Human1.42788604
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.40939489
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40466123
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38680256
36GATA4_25053715_ChIP-Seq_YYC3_Human1.36737030
37* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34719462
38TP53_18474530_ChIP-ChIP_U2OS_Human1.34577395
39AHR_22903824_ChIP-Seq_MCF-7_Human1.32690326
40GATA6_25053715_ChIP-Seq_YYC3_Human1.32196699
41GATA3_24758297_ChIP-Seq_MCF-7_Human1.31667141
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.31541094
43* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31255632
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26734464
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25521032
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.19394036
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.15886726
48AR_21909140_ChIP-Seq_LNCAP_Human1.15651769
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.15554095
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.14797883
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13723174
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12506760
53EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11699627
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11487693
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05337639
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.01785446
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00372629
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00014483
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98391843
60BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98376343
61PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97426143
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96382750
63CLOCK_20551151_ChIP-Seq_293T_Human0.96342163
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94786241
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94647702
66BRD4_25478319_ChIP-Seq_HGPS_Human0.88862873
67TP53_16413492_ChIP-PET_HCT116_Human0.87363181
68ARNT_22903824_ChIP-Seq_MCF-7_Human0.86865279
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85654886
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82811346
71SMC4_20622854_ChIP-Seq_HELA_Human0.80913206
72TP53_22127205_ChIP-Seq_IMR90_Human0.80679875
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79180597
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79160274
75TBX20_22328084_ChIP-Seq_HEART_Mouse0.74903280
76TBX20_22080862_ChIP-Seq_HEART_Mouse0.74903280
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.74743674
78ELF5_23300383_ChIP-Seq_T47D_Human0.74084186
79SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72594075
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72397391
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69853041
82SMAD3_21741376_ChIP-Seq_HESCs_Human0.67372990
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.66782039
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65681588
85LXR_22292898_ChIP-Seq_THP-1_Human0.65112830
86KLF4_18555785_ChIP-Seq_MESCs_Mouse0.64276761
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.63748442
88CTCF_27219007_Chip-Seq_Bcells_Human0.63320281
89TP53_23651856_ChIP-Seq_MEFs_Mouse0.63243380
90EOMES_21245162_ChIP-Seq_HESCs_Human0.62827802
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.62701952
92SA1_27219007_Chip-Seq_ERYTHROID_Human0.61123158
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.60639620
94EP300_21415370_ChIP-Seq_HL-1_Mouse0.59109631
95CHD1_26751641_Chip-Seq_LNCaP_Human0.57841527
96PPARA_22158963_ChIP-Seq_LIVER_Mouse0.57185769
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.56750852
98RBPJ_21746931_ChIP-Seq_IB4_Human0.56744509
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56249924
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.52103856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology6.83187627
2MP0010234_abnormal_vibrissa_follicle5.59929149
3MP0002796_impaired_skin_barrier5.28416145
4MP0005275_abnormal_skin_tensile4.46694707
5MP0003941_abnormal_skin_development3.78979895
6MP0005501_abnormal_skin_physiology3.48061679
7MP0010678_abnormal_skin_adnexa3.47425791
8MP0001216_abnormal_epidermal_layer3.33634397
9MP0002060_abnormal_skin_morphology3.32760073
10MP0000383_abnormal_hair_follicle3.24078459
11MP0003453_abnormal_keratinocyte_physiol3.22314149
12MP0000467_abnormal_esophagus_morphology3.18054951
13MP0000762_abnormal_tongue_morphology3.13453105
14MP0002098_abnormal_vibrissa_morphology2.96995547
15MP0000566_synostosis2.87287568
16MP0004381_abnormal_hair_follicle2.85146317
17MP0003566_abnormal_cell_adhesion2.84723179
18MP0003705_abnormal_hypodermis_morpholog2.60472602
19MP0010771_integument_phenotype2.58852696
20MP0000377_abnormal_hair_follicle2.37369046
21MP0005409_darkened_coat_color2.30765072
22MP0004264_abnormal_extraembryonic_tissu2.24940963
23MP0009053_abnormal_anal_canal2.13231302
24MP0005023_abnormal_wound_healing2.07938668
25MP0002234_abnormal_pharynx_morphology1.95110330
26MP0004272_abnormal_basement_membrane1.81543285
27MP0000647_abnormal_sebaceous_gland1.79256733
28MP0000427_abnormal_hair_cycle1.73810013
29MP0001849_ear_inflammation1.66529185
30MP0003950_abnormal_plasma_membrane1.53107293
31MP0009931_abnormal_skin_appearance1.50849553
32MP0004947_skin_inflammation1.46076917
33MP0010352_gastrointestinal_tract_polyps1.37875980
34MP0009780_abnormal_chondrocyte_physiolo1.34638214
35MP0000367_abnormal_coat/_hair1.33498085
36MP0004782_abnormal_surfactant_physiolog1.33437986
37MP0000537_abnormal_urethra_morphology1.30633436
38MP0003315_abnormal_perineum_morphology1.23002772
39MP0001191_abnormal_skin_condition1.22833273
40MP0000678_abnormal_parathyroid_gland1.21137233
41MP0005377_hearing/vestibular/ear_phenot1.20006214
42MP0003878_abnormal_ear_physiology1.20006214
43MP0003191_abnormal_cellular_cholesterol1.13831033
44MP0001243_abnormal_dermal_layer1.12501797
45MP0005257_abnormal_intraocular_pressure1.07451855
46MP0009379_abnormal_foot_pigmentation1.03685849
47MP0003806_abnormal_nucleotide_metabolis1.01989237
48MP0000627_abnormal_mammary_gland1.01673273
49MP0008438_abnormal_cutaneous_collagen0.89990067
50MP0008260_abnormal_autophagy0.86576821
51MP0004019_abnormal_vitamin_homeostasis0.86516209
52MP0010030_abnormal_orbit_morphology0.86301182
53MP0008789_abnormal_olfactory_epithelium0.83311634
54MP0003755_abnormal_palate_morphology0.82473188
55MP0001851_eye_inflammation0.79131590
56MP0002095_abnormal_skin_pigmentation0.74599877
57MP0002177_abnormal_outer_ear0.73692500
58MP0002877_abnormal_melanocyte_morpholog0.73096196
59MP0001340_abnormal_eyelid_morphology0.69392049
60MP0001958_emphysema0.69354091
61MP0000003_abnormal_adipose_tissue0.66356074
62MP0002282_abnormal_trachea_morphology0.64758023
63MP0003091_abnormal_cell_migration0.64243482
64MP0005248_abnormal_Harderian_gland0.63543854
65MP0004885_abnormal_endolymph0.59532062
66MP0005083_abnormal_biliary_tract0.55550490
67MP0002111_abnormal_tail_morphology0.55086979
68MP0001661_extended_life_span0.54431833
69MP0005197_abnormal_uvea_morphology0.53636228
70MP0005360_urolithiasis0.52976371
71MP0000858_altered_metastatic_potential0.52208285
72MP0003786_premature_aging0.51713794
73MP0005193_abnormal_anterior_eye0.51532584
74MP0010368_abnormal_lymphatic_system0.50468799
75MP0005394_taste/olfaction_phenotype0.50303230
76MP0005499_abnormal_olfactory_system0.50303230
77MP0006138_congestive_heart_failure0.48451202
78MP0000013_abnormal_adipose_tissue0.48028775
79MP0000538_abnormal_urinary_bladder0.45887349
80MP0003638_abnormal_response/metabolism_0.45302539
81MP0005076_abnormal_cell_differentiation0.45278426
82MP0005330_cardiomyopathy0.45091590
83MP0001299_abnormal_eye_distance/0.43851085
84MP0002697_abnormal_eye_size0.43344686
85MP0003045_fibrosis0.42144736
86MP0001784_abnormal_fluid_regulation0.41973348
87MP0005075_abnormal_melanosome_morpholog0.41865475
88MP0002233_abnormal_nose_morphology0.39732183
89MP0000462_abnormal_digestive_system0.39399826
90MP0002896_abnormal_bone_mineralization0.35692807
91MP0005375_adipose_tissue_phenotype0.34630903
92MP0004233_abnormal_muscle_weight0.33969041
93MP0000750_abnormal_muscle_regeneration0.33664049
94MP0001879_abnormal_lymphatic_vessel0.33527052
95MP0003385_abnormal_body_wall0.32545431
96MP0000465_gastrointestinal_hemorrhage0.32203718
97MP0000432_abnormal_head_morphology0.31851915
98MP0000015_abnormal_ear_pigmentation0.31778243
99MP0004185_abnormal_adipocyte_glucose0.30633154
100MP0003935_abnormal_craniofacial_develop0.30126881

Predicted human phenotypes

RankGene SetZ-score
1Plantar hyperkeratosis (HP:0007556)8.09359256
2Onycholysis (HP:0001806)8.02032349
3Abnormality of nail color (HP:0100643)7.92318808
4Milia (HP:0001056)7.85590569
5Fragile nails (HP:0001808)7.48373814
6Palmoplantar hyperkeratosis (HP:0000972)7.01723462
7Alopecia of scalp (HP:0002293)6.83907995
8Thick nail (HP:0001805)6.78874058
9Palmar hyperkeratosis (HP:0010765)6.62874069
10Right ventricular cardiomyopathy (HP:0011663)5.98484262
11Atrophic scars (HP:0001075)5.60689185
12Nail dystrophy (HP:0008404)5.45186455
13Hypotrichosis (HP:0001006)5.31423246
14Pili torti (HP:0003777)4.97762666
15Ridged nail (HP:0001807)4.49674973
16Abnormal hair laboratory examination (HP:0003328)4.26791358
17Abnormal blistering of the skin (HP:0008066)4.19364711
18Woolly hair (HP:0002224)4.18329729
19Oral leukoplakia (HP:0002745)3.93042876
20Sparse eyelashes (HP:0000653)3.81193872
21Erythema (HP:0010783)3.73084277
22Congenital ichthyosiform erythroderma (HP:0007431)3.72297429
23Erythroderma (HP:0001019)3.63903542
24Selective tooth agenesis (HP:0001592)3.48425753
25Lip pit (HP:0100267)3.46809196
26Sparse scalp hair (HP:0002209)3.45681642
27Corneal erosion (HP:0200020)3.42897315
28Natal tooth (HP:0000695)3.42542338
29Abnormality of the axillary hair (HP:0100134)3.39781186
30Abnormality of secondary sexual hair (HP:0009888)3.39781186
31Popliteal pterygium (HP:0009756)3.38160084
32Dry hair (HP:0011359)3.34203686
33Hypoplasia of dental enamel (HP:0006297)3.26850941
34Absent eyelashes (HP:0000561)3.20982021
35Pterygium (HP:0001059)3.18871582
36Hypoplastic labia majora (HP:0000059)3.17621444
37Increased IgE level (HP:0003212)3.13608673
38Fragile skin (HP:0001030)3.05906832
39Palmoplantar keratoderma (HP:0000982)3.00029247
40Amniotic constriction ring (HP:0009775)2.96051340
41Abnormality of placental membranes (HP:0011409)2.96051340
42Abnormality of the labia majora (HP:0012881)2.93814419
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.73360194
44Ectropion (HP:0000656)2.72259568
45Ankyloglossia (HP:0010296)2.70874768
46Advanced eruption of teeth (HP:0006288)2.70389348
47Abnormality of the salivary glands (HP:0010286)2.69322962
48Aplasia cutis congenita (HP:0001057)2.68654169
49Abnormality of the neuromuscular junction (HP:0003398)2.57681903
50Fatigable weakness (HP:0003473)2.57681903
51Anonychia (HP:0001798)2.46230112
52Oligodontia (HP:0000677)2.39518628
53Blepharitis (HP:0000498)2.32468062
54Carious teeth (HP:0000670)2.26219567
55Ventricular tachycardia (HP:0004756)2.21459649
56Parakeratosis (HP:0001036)2.20004817
57Abnormality of oral frenula (HP:0000190)2.18372148
58Trismus (HP:0000211)2.14118007
59Poikiloderma (HP:0001029)2.12750774
60Hyperhidrosis (HP:0000975)2.12149622
61Abnormality of the dental root (HP:0006486)2.07934363
62Taurodontia (HP:0000679)2.07934363
63Abnormality of permanent molar morphology (HP:0011071)2.07934363
64Acanthosis nigricans (HP:0000956)2.02957106
65Hypodontia (HP:0000668)2.01135532
66Absent hair (HP:0002298)2.00905344
67Amelogenesis imperfecta (HP:0000705)1.98558514
68Hypohidrosis (HP:0000966)1.97649701
69Cheilitis (HP:0100825)1.95364438
70Brittle hair (HP:0002299)1.95346806
71Abnormality of molar morphology (HP:0011070)1.93956257
72Abnormality of molar (HP:0011077)1.93956257
73Short nail (HP:0001799)1.92654256
74Abnormality of the fingernails (HP:0001231)1.88502607
75Corneal dystrophy (HP:0001131)1.85883425
76Dehydration (HP:0001944)1.83641165
77Abnormality of the dental pulp (HP:0006479)1.83036365
78Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82973228
79Follicular hyperkeratosis (HP:0007502)1.81791212
80Labial hypoplasia (HP:0000066)1.80578664
81Nasolacrimal duct obstruction (HP:0000579)1.77387668
82Hypoplasia of the uterus (HP:0000013)1.76263338
83Squamous cell carcinoma (HP:0002860)1.76105797
84Conjunctival hamartoma (HP:0100780)1.74450573
85Abnormality of the distal phalanges of the toes (HP:0010182)1.72464197
86Xerostomia (HP:0000217)1.71838538
87Malnutrition (HP:0004395)1.70671828
88Multifactorial inheritance (HP:0001426)1.70157841
89Laryngomalacia (HP:0001601)1.69382226
90Hypoplastic female external genitalia (HP:0012815)1.68295724
91Ureteral duplication (HP:0000073)1.68265918
92Duplicated collecting system (HP:0000081)1.67613329
93Breast hypoplasia (HP:0003187)1.65574352
94Abnormality of hair growth rate (HP:0011363)1.65370135
95Slow-growing hair (HP:0002217)1.65370135
96Vascular calcification (HP:0004934)1.60843393
97Neonatal death (HP:0003811)1.59200305
98Reduced subcutaneous adipose tissue (HP:0003758)1.58821947
99Pustule (HP:0200039)1.56314633
100Recurrent corneal erosions (HP:0000495)1.53001971

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.70340861
2MST1R5.64769642
3MET3.95285013
4LATS13.35217214
5PBK3.01541734
6MAP3K122.85533644
7EPHB22.83437141
8MAP3K22.83069947
9ARAF2.49709244
10LATS22.23979918
11MST42.19967427
12PTK22.14738054
13MAP3K92.11943133
14MAPKAPK32.11711435
15NME11.96301836
16STK241.91200497
17FER1.90646846
18NME21.84602456
19FLT31.81914676
20MAP3K31.79187471
21TGFBR11.77561103
22PAK41.70332751
23PIM21.69053396
24MYLK1.67200650
25STK38L1.64059208
26NTRK11.63975076
27RIPK11.58158378
28MAP3K61.49098587
29TESK11.35708952
30RPS6KB21.31003806
31EPHB11.29986049
32STK381.26163300
33LMTK21.11224578
34SIK11.09517889
35TGFBR21.07297338
36TRPM71.06023891
37STK101.01393188
38PDGFRA1.00886283
39ERN11.00695731
40CDK120.93582130
41ABL20.87607252
42STK30.80752188
43ILK0.75586776
44IRAK30.69279694
45PRKCI0.68595958
46RAF10.67779258
47KSR20.65253577
48SMG10.59335770
49EIF2AK10.56791061
50MAPKAPK50.55363528
51TTN0.53805268
52CAMK2G0.52284565
53BMX0.51911221
54MAP2K10.51632505
55RPS6KA40.51134401
56ERBB40.49209756
57MUSK0.49068863
58MAP3K10.48738135
59EIF2AK30.48601349
60PDGFRB0.46311314
61MAPKAPK20.45514127
62PTK2B0.45137492
63BCR0.42202252
64ADRBK10.42028291
65PTK60.41929363
66PDK20.41795423
67MTOR0.41522927
68NEK10.40328257
69FGFR10.39907801
70BUB10.39395308
71KSR10.38920149
72RPS6KA20.38823915
73PRKCE0.38392937
74MOS0.37703387
75CSNK1A1L0.36265245
76DAPK10.35713429
77MAP3K80.34708034
78MAP2K60.31855968
79BRAF0.31754382
80PRKD20.31730893
81STK160.31488412
82AURKB0.29603266
83ROCK10.29376492
84WNK10.28504985
85LRRK20.27970668
86ROCK20.27475972
87ERBB20.27291726
88IKBKB0.26617114
89DAPK30.23886614
90MAPK150.23262621
91LIMK10.22376671
92NEK60.22366386
93CSNK1G30.20157571
94RET0.19836770
95ERBB30.19395147
96IGF1R0.19118356
97AURKA0.18154463
98TRIB30.16639349
99CAMK2B0.14788538
100CDC42BPA0.14539673

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.28280705
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.11372918
3Small cell lung cancer_Homo sapiens_hsa052222.65010747
4Sphingolipid metabolism_Homo sapiens_hsa006002.32546198
5Focal adhesion_Homo sapiens_hsa045102.30849921
6Adherens junction_Homo sapiens_hsa045202.16495604
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.14436304
8Phenylalanine metabolism_Homo sapiens_hsa003602.04322458
9p53 signaling pathway_Homo sapiens_hsa041152.03019195
10Proteasome_Homo sapiens_hsa030502.02820857
11Amoebiasis_Homo sapiens_hsa051461.90236499
12Galactose metabolism_Homo sapiens_hsa000521.83715770
13Fatty acid elongation_Homo sapiens_hsa000621.69423901
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66177805
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64015737
16Thyroid cancer_Homo sapiens_hsa052161.62658402
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.60913313
18Hippo signaling pathway_Homo sapiens_hsa043901.54416961
19Bladder cancer_Homo sapiens_hsa052191.52810863
20Proteoglycans in cancer_Homo sapiens_hsa052051.50207124
21Fructose and mannose metabolism_Homo sapiens_hsa000511.49282278
22Steroid biosynthesis_Homo sapiens_hsa001001.39227873
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38999855
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33242662
25Tight junction_Homo sapiens_hsa045301.31893380
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30537724
27Regulation of actin cytoskeleton_Homo sapiens_hsa048101.30109436
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.29806519
29Histidine metabolism_Homo sapiens_hsa003401.27952341
30Tyrosine metabolism_Homo sapiens_hsa003501.22802369
31Arachidonic acid metabolism_Homo sapiens_hsa005901.22386336
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19923223
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17149519
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.11285107
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10001909
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09038346
37Axon guidance_Homo sapiens_hsa043601.08224110
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06874061
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04608998
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03550970
41Chemical carcinogenesis_Homo sapiens_hsa052041.03296142
42Glutathione metabolism_Homo sapiens_hsa004801.02459798
43N-Glycan biosynthesis_Homo sapiens_hsa005101.02179979
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00949964
45Hedgehog signaling pathway_Homo sapiens_hsa043400.96558778
46MicroRNAs in cancer_Homo sapiens_hsa052060.96549625
47Shigellosis_Homo sapiens_hsa051310.94850486
48Pathways in cancer_Homo sapiens_hsa052000.94678776
49Pentose phosphate pathway_Homo sapiens_hsa000300.94188179
50Endocytosis_Homo sapiens_hsa041440.93528874
51Sulfur metabolism_Homo sapiens_hsa009200.93129522
52Basal cell carcinoma_Homo sapiens_hsa052170.92971907
53Ether lipid metabolism_Homo sapiens_hsa005650.92000116
54Ovarian steroidogenesis_Homo sapiens_hsa049130.91432738
55ErbB signaling pathway_Homo sapiens_hsa040120.89183589
56Salmonella infection_Homo sapiens_hsa051320.88821341
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88582919
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88463443
59Circadian rhythm_Homo sapiens_hsa047100.85929675
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.84805772
61Vibrio cholerae infection_Homo sapiens_hsa051100.84589484
62Retinol metabolism_Homo sapiens_hsa008300.82883190
63Linoleic acid metabolism_Homo sapiens_hsa005910.78583868
64Pancreatic cancer_Homo sapiens_hsa052120.70796644
65Dilated cardiomyopathy_Homo sapiens_hsa054140.69689328
66VEGF signaling pathway_Homo sapiens_hsa043700.69551106
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66786440
68Glioma_Homo sapiens_hsa052140.66604595
69GnRH signaling pathway_Homo sapiens_hsa049120.66312314
70Toxoplasmosis_Homo sapiens_hsa051450.63914095
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63259061
72beta-Alanine metabolism_Homo sapiens_hsa004100.62252557
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61522073
74Renal cell carcinoma_Homo sapiens_hsa052110.59221808
75Arginine biosynthesis_Homo sapiens_hsa002200.57798276
76Vitamin digestion and absorption_Homo sapiens_hsa049770.57551093
77Other glycan degradation_Homo sapiens_hsa005110.57258586
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56853054
79Folate biosynthesis_Homo sapiens_hsa007900.56661894
80Hepatitis C_Homo sapiens_hsa051600.55248639
81TGF-beta signaling pathway_Homo sapiens_hsa043500.54660246
82Chronic myeloid leukemia_Homo sapiens_hsa052200.53928666
83Starch and sucrose metabolism_Homo sapiens_hsa005000.51171897
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51155764
85Protein digestion and absorption_Homo sapiens_hsa049740.51074280
86Notch signaling pathway_Homo sapiens_hsa043300.47496092
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.46703400
88Inositol phosphate metabolism_Homo sapiens_hsa005620.45773975
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45660760
90Insulin signaling pathway_Homo sapiens_hsa049100.44991421
91Lysosome_Homo sapiens_hsa041420.43729590
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.41707271
93Pyruvate metabolism_Homo sapiens_hsa006200.41546306
94Melanogenesis_Homo sapiens_hsa049160.40478050
95Sulfur relay system_Homo sapiens_hsa041220.39638323
96Glycerolipid metabolism_Homo sapiens_hsa005610.38775598
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.37802099
98Phototransduction_Homo sapiens_hsa047440.37208416
99Nucleotide excision repair_Homo sapiens_hsa034200.37030712
100Dorso-ventral axis formation_Homo sapiens_hsa043200.36297353

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