ANXA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.25412150
2keratinization (GO:0031424)8.90770735
3desmosome organization (GO:0002934)7.22734452
4hair cycle (GO:0042633)6.52093947
5molting cycle (GO:0042303)6.52093947
6multicellular organismal water homeostasis (GO:0050891)5.85247119
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.76776337
8detection of bacterium (GO:0016045)5.39433602
9ribosomal small subunit assembly (GO:0000028)5.34441264
10L-phenylalanine metabolic process (GO:0006558)5.32703871
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.32703871
12phospholipid efflux (GO:0033700)5.27267289
13viral transcription (GO:0019083)5.14129999
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08141211
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.08141211
16detection of other organism (GO:0098543)5.06471414
17hepatocyte apoptotic process (GO:0097284)5.01954874
18translational termination (GO:0006415)4.92235185
19keratinocyte differentiation (GO:0030216)4.90211929
20water homeostasis (GO:0030104)4.82956985
21sphingoid metabolic process (GO:0046519)4.78021186
22regulation of cell proliferation involved in kidney development (GO:1901722)4.74314872
23antigen processing and presentation via MHC class Ib (GO:0002475)4.73099470
24definitive hemopoiesis (GO:0060216)4.69215255
25regulation of cholesterol esterification (GO:0010872)4.57407737
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53629064
27L-phenylalanine catabolic process (GO:0006559)4.53629064
28phospholipid scrambling (GO:0017121)4.46771173
29negative regulation of fibrinolysis (GO:0051918)4.44478208
30ribosomal small subunit biogenesis (GO:0042274)4.40117251
31lipoxygenase pathway (GO:0019372)4.35804993
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34090682
33peptide cross-linking (GO:0018149)4.32576619
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.31086333
35regulation of fibrinolysis (GO:0051917)4.30119917
36protein targeting to ER (GO:0045047)4.24927798
37urea metabolic process (GO:0019627)4.23483720
38regulation of natural killer cell differentiation (GO:0032823)4.23016024
39cotranslational protein targeting to membrane (GO:0006613)4.22995284
40antigen processing and presentation of endogenous antigen (GO:0019883)4.17309225
41long-chain fatty acid biosynthetic process (GO:0042759)4.16862677
42epoxygenase P450 pathway (GO:0019373)4.16301372
43regulation of protein activation cascade (GO:2000257)4.15674382
44establishment of protein localization to endoplasmic reticulum (GO:0072599)4.09331636
45urea cycle (GO:0000050)4.06573865
46translational elongation (GO:0006414)4.04765325
47sphingosine metabolic process (GO:0006670)4.02880833
48protein localization to endoplasmic reticulum (GO:0070972)4.00248771
49epidermal cell differentiation (GO:0009913)3.97257742
50protein carboxylation (GO:0018214)3.96652319
51peptidyl-glutamic acid carboxylation (GO:0017187)3.96652319
52regulation of complement activation (GO:0030449)3.91578480
53positive regulation of keratinocyte differentiation (GO:0045618)3.91258515
54regulation of ruffle assembly (GO:1900027)3.90447939
55viral life cycle (GO:0019058)3.87334891
56glyoxylate metabolic process (GO:0046487)3.86990115
57DNA deamination (GO:0045006)3.86933983
58skin morphogenesis (GO:0043589)3.86344772
59COPI coating of Golgi vesicle (GO:0048205)3.84452286
60Golgi transport vesicle coating (GO:0048200)3.84452286
61nitrogen cycle metabolic process (GO:0071941)3.77760963
62cyclooxygenase pathway (GO:0019371)3.76715773
63negative regulation of stress fiber assembly (GO:0051497)3.72789757
64complement activation, alternative pathway (GO:0006957)3.71153758
65positive regulation of glomerulus development (GO:0090193)3.68611764
66positive regulation of cellular amine metabolic process (GO:0033240)3.62985541
67cellular protein complex disassembly (GO:0043624)3.59309394
68phenylpropanoid metabolic process (GO:0009698)3.57012252
69high-density lipoprotein particle remodeling (GO:0034375)3.56943808
70negative regulation of sterol transport (GO:0032372)3.56783102
71negative regulation of cholesterol transport (GO:0032375)3.56783102
72regulation of transforming growth factor beta1 production (GO:0032908)3.56657547
73very-low-density lipoprotein particle assembly (GO:0034379)3.53721006
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53121275
75interferon-gamma secretion (GO:0072643)3.51454706
76translational initiation (GO:0006413)3.49987792
77plasma lipoprotein particle assembly (GO:0034377)3.49038947
78diol metabolic process (GO:0034311)3.47712500
79omega-hydroxylase P450 pathway (GO:0097267)3.43951502
80regulation of cholesterol biosynthetic process (GO:0045540)3.43168741
81regulation of triglyceride catabolic process (GO:0010896)3.39164666
82glucose 6-phosphate metabolic process (GO:0051156)3.38933966
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.37726827
84maturation of SSU-rRNA (GO:0030490)3.37356863
85positive regulation of interleukin-8 secretion (GO:2000484)3.37353023
86fibrinolysis (GO:0042730)3.36079733
87intermediate filament organization (GO:0045109)3.33741006
88positive regulation of lipoprotein lipase activity (GO:0051006)3.31767516
89positive regulation of triglyceride lipase activity (GO:0061365)3.31767516
90epidermis development (GO:0008544)3.31685914
91amino sugar catabolic process (GO:0046348)3.28785145
92glucosamine-containing compound catabolic process (GO:1901072)3.27847298
93regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.27133708
94blood coagulation, intrinsic pathway (GO:0007597)3.25292999
95negative regulation of lipase activity (GO:0060192)3.24495447
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21197195
97reverse cholesterol transport (GO:0043691)3.18690458
98neutrophil activation involved in immune response (GO:0002283)3.16308387
99pentose-phosphate shunt (GO:0006098)3.16141664
100protein-lipid complex remodeling (GO:0034368)3.15869186
101macromolecular complex remodeling (GO:0034367)3.15869186
102plasma lipoprotein particle remodeling (GO:0034369)3.15869186
103regulation of necrotic cell death (GO:0010939)3.15619993
104proline metabolic process (GO:0006560)3.13839579
105alpha-linolenic acid metabolic process (GO:0036109)3.13202557
106cholesterol efflux (GO:0033344)3.10947975
107regulation of hypersensitivity (GO:0002883)3.09481578
108amyloid precursor protein catabolic process (GO:0042987)3.08742948
109positive regulation of B cell differentiation (GO:0045579)3.07753845
110protein complex disassembly (GO:0043241)3.06731707
111xenobiotic catabolic process (GO:0042178)3.04605308
112epithelial cell differentiation involved in prostate gland development (GO:0060742)3.03445837
113G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.01904549
114positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99112663
115protein-lipid complex assembly (GO:0065005)2.98249935
116detection of external biotic stimulus (GO:0098581)2.97389047
117positive regulation of epidermal cell differentiation (GO:0045606)2.96013931
118negative regulation of erythrocyte differentiation (GO:0045647)2.95580520
119platelet dense granule organization (GO:0060155)2.94792038
120ribosomal large subunit biogenesis (GO:0042273)2.94127167
121NADPH regeneration (GO:0006740)2.92210927
122acute-phase response (GO:0006953)2.91636423
123positive regulation of lipid catabolic process (GO:0050996)2.91620661
124amyloid precursor protein metabolic process (GO:0042982)2.90543341
125biotin metabolic process (GO:0006768)2.90234319
126protein targeting to membrane (GO:0006612)2.89260420
127keratinocyte proliferation (GO:0043616)2.88623313
128fatty acid elongation (GO:0030497)2.87294950
129maternal placenta development (GO:0001893)2.85232266
130macromolecular complex disassembly (GO:0032984)2.85064650
131positive regulation of hormone metabolic process (GO:0032352)2.81684937
132negative regulation of blood coagulation (GO:0030195)2.81317192
133negative regulation of hemostasis (GO:1900047)2.81317192
134regulation of cholesterol metabolic process (GO:0090181)2.81138694
135negative regulation of kidney development (GO:0090185)2.81053271
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.80734945
137flavonoid metabolic process (GO:0009812)2.79412174
138citrulline biosynthetic process (GO:0019240)2.79339389
139positive regulation of antigen processing and presentation (GO:0002579)2.78416133
140plasma lipoprotein particle clearance (GO:0034381)2.76644650
141acute inflammatory response (GO:0002526)2.75664330
142negative regulation of protein activation cascade (GO:2000258)2.75260076
143response to interferon-alpha (GO:0035455)2.75152548
144plasma lipoprotein particle organization (GO:0071827)2.73306444
145megakaryocyte development (GO:0035855)2.72345167
146positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.70529079
147linoleic acid metabolic process (GO:0043651)2.70304497
148very long-chain fatty acid metabolic process (GO:0000038)2.69305631
149regulation of lipoprotein particle clearance (GO:0010984)2.69299629
150glucose catabolic process (GO:0006007)2.69113501
151regulation of necroptotic process (GO:0060544)2.66841324
152endosome to melanosome transport (GO:0035646)2.65561645
153endosome to pigment granule transport (GO:0043485)2.65561645
154L-fucose metabolic process (GO:0042354)2.63765483
155L-fucose catabolic process (GO:0042355)2.63765483
156fucose catabolic process (GO:0019317)2.63765483
157intestinal epithelial cell development (GO:0060576)2.63273617
158cellular glucuronidation (GO:0052695)2.61794296
159maintenance of gastrointestinal epithelium (GO:0030277)2.61164059
160regulation of cholesterol homeostasis (GO:2000188)2.59578539
161drug catabolic process (GO:0042737)2.58016792
162pentose metabolic process (GO:0019321)2.57899935
163glutamine family amino acid biosynthetic process (GO:0009084)2.57688506
164proline biosynthetic process (GO:0006561)2.56487976
165intestinal cholesterol absorption (GO:0030299)2.55944160
166low-density lipoprotein particle remodeling (GO:0034374)2.54600843
167negative regulation of coagulation (GO:0050819)2.54450090
168negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.54250454
169negative regulation of fatty acid metabolic process (GO:0045922)2.53969258
170nuclear-transcribed mRNA catabolic process (GO:0000956)2.53805868
171citrulline metabolic process (GO:0000052)2.53539343
172positive regulation of blood coagulation (GO:0030194)2.53368325
173positive regulation of hemostasis (GO:1900048)2.53368325
174detection of biotic stimulus (GO:0009595)2.52435909
175Arp2/3 complex-mediated actin nucleation (GO:0034314)2.52067415
176regulation of interleukin-8 secretion (GO:2000482)2.51861743
177interleukin-1-mediated signaling pathway (GO:0070498)2.51496970
178negative regulation of cell size (GO:0045792)2.50802827
179positive regulation of natural killer cell differentiation (GO:0032825)2.50612581
180negative regulation of fatty acid biosynthetic process (GO:0045717)2.50242708
181protein-lipid complex subunit organization (GO:0071825)2.50193195
182regulation of natural killer cell activation (GO:0032814)2.49836741
183negative regulation of actin filament bundle assembly (GO:0032232)2.45780074
184hemidesmosome assembly (GO:0031581)2.44616914
185positive regulation of megakaryocyte differentiation (GO:0045654)2.43724821
186mRNA catabolic process (GO:0006402)2.42777146
187translation (GO:0006412)2.42583035
188T cell homeostasis (GO:0043029)2.42060012
189regulation of antigen processing and presentation (GO:0002577)2.41441120
190negative regulation of necroptotic process (GO:0060546)2.40397307
191establishment of skin barrier (GO:0061436)10.2852638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.67426124
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.58327590
3ESR1_20079471_ChIP-ChIP_T-47D_Human4.57095962
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.22607134
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.00992743
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.96102561
7SCL_19346495_ChIP-Seq_HPC-7_Human3.38311010
8E2F7_22180533_ChIP-Seq_HELA_Human3.37454563
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.03060573
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86728893
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.83299153
12* RACK7_27058665_Chip-Seq_MCF-7_Human2.74615372
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54874256
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54682903
15* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.53822373
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.53399455
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.49749091
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.40878559
19RUNX1_27514584_Chip-Seq_MCF-7_Human2.18257889
20* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17601539
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15574561
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.11256845
23GATA1_22025678_ChIP-Seq_K562_Human2.09934534
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.04596767
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01491276
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99069232
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97310943
28ZNF263_19887448_ChIP-Seq_K562_Human1.97105577
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94637040
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.92046912
31LXR_22292898_ChIP-Seq_THP-1_Human1.85674735
32* GATA3_24758297_ChIP-Seq_MCF-7_Human1.78885100
33SPI1_23547873_ChIP-Seq_NB4_Human1.77966015
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76828528
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70370711
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70185670
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68164468
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67616161
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65784770
40* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65627341
41* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.64461376
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64147724
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62105601
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55897330
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54466920
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52351669
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.50818233
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50362043
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49401116
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.49056004
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.48262296
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.48262296
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47235873
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46392634
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45265355
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44952901
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44457243
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44410737
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44235359
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.43370990
61VDR_24763502_ChIP-Seq_THP-1_Human1.41980628
62VDR_21846776_ChIP-Seq_THP-1_Human1.41242902
63* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40799970
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39964983
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39271098
66* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37250177
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35908731
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33296727
69AHR_22903824_ChIP-Seq_MCF-7_Human1.33023142
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31218601
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30252024
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.28595327
73STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27058411
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.26723663
75MYB_26560356_Chip-Seq_TH2_Human1.24660936
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24532636
77SMC4_20622854_ChIP-Seq_HELA_Human1.23873639
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.22196324
79* MAF_26560356_Chip-Seq_TH1_Human1.21860514
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21412231
81TCF7_22412390_ChIP-Seq_EML_Mouse1.20893801
82CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20708789
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.20201190
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19787944
85* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19437954
86KDM2B_26808549_Chip-Seq_DND41_Human1.18404578
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.18169759
88FOXA2_19822575_ChIP-Seq_HepG2_Human1.18092186
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17725692
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17198674
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16635788
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16612615
93GATA4_25053715_ChIP-Seq_YYC3_Human1.16541795
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16197834
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16120462
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16104996
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15589779
98FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15569860
99* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14923035
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14907297
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14877724
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14091121
103P68_20966046_ChIP-Seq_HELA_Human1.13915487
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13534457
105CLOCK_20551151_ChIP-Seq_293T_Human1.13228265
106* ATF3_27146783_Chip-Seq_COLON_Human1.13207947
107MYB_26560356_Chip-Seq_TH1_Human1.12614133
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12304640
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10154533
110BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.10007358
111* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09356324
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08684214
113* UTX_26944678_Chip-Seq_JUKART_Human1.08350979
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.08121239
115CREB1_26743006_Chip-Seq_LNCaP_Human1.06653093
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06573930
117ELF5_23300383_ChIP-Seq_T47D_Human1.06555083
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06089534
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05721207
120* SOX2_20726797_ChIP-Seq_SW620_Human1.04672055
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04478781
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.02531949
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.02435166
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01383219
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01099026
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00772382
127* TET1_21451524_ChIP-Seq_MESCs_Mouse0.99894804
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99736284
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.98289676
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.98200207
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97690924
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97275957
133PU_27001747_Chip-Seq_BMDM_Mouse0.96899229
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96750152
135NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96708913
136* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96659954
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96316024
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.95989400
139* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95656871
140SPI1_23127762_ChIP-Seq_K562_Human0.94854134
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93860616
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.93770301
143VDR_23849224_ChIP-Seq_CD4+_Human0.93726866
144GATA1_19941826_ChIP-Seq_K562_Human0.93528978
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93205936
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.92802995
147VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91926125
148MYC_22102868_ChIP-Seq_BL_Human0.91335625
149KDM2B_26808549_Chip-Seq_K562_Human0.90953639
150PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90872363
151CEBPB_22108803_ChIP-Seq_LS180_Human0.90788976
152ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90275640
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.90060761
154BCOR_27268052_Chip-Seq_Bcells_Human0.89760402
155MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89554540
156BCL6_27268052_Chip-Seq_Bcells_Human0.89418958
157PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89266347
158KDM5A_27292631_Chip-Seq_BREAST_Human0.89208692
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88874786
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88854691
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88384637
162CHD1_26751641_Chip-Seq_LNCaP_Human0.87568777
163* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87265345
164PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87060877
165HNF4A_19822575_ChIP-Seq_HepG2_Human0.87048485
166GATA6_25053715_ChIP-Seq_YYC3_Human0.86851918
167KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86458395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.98939245
2MP0010234_abnormal_vibrissa_follicle5.19702946
3MP0005275_abnormal_skin_tensile4.71970646
4MP0005451_abnormal_body_composition4.50077261
5MP0005501_abnormal_skin_physiology4.40238078
6MP0003941_abnormal_skin_development3.99346459
7MP0004381_abnormal_hair_follicle3.44763318
8MP0002139_abnormal_hepatobiliary_system3.44580576
9MP0005365_abnormal_bile_salt3.07107208
10MP0004947_skin_inflammation2.91871597
11MP0002060_abnormal_skin_morphology2.87769053
12MP0001216_abnormal_epidermal_layer2.75451036
13MP0005083_abnormal_biliary_tract2.72050647
14MP0005360_urolithiasis2.60803758
15MP0001666_abnormal_nutrient_absorption2.56821052
16MP0002098_abnormal_vibrissa_morphology2.50434322
17MP0005085_abnormal_gallbladder_physiolo2.48435452
18MP0010678_abnormal_skin_adnexa2.47581334
19MP0010771_integument_phenotype2.46004172
20MP0000579_abnormal_nail_morphology2.41125634
21MP0008875_abnormal_xenobiotic_pharmacok2.39520223
22MP0000647_abnormal_sebaceous_gland2.35331825
23MP0003191_abnormal_cellular_cholesterol2.26630195
24MP0000383_abnormal_hair_follicle2.22455341
25MP0000465_gastrointestinal_hemorrhage2.17188348
26MP0003724_increased_susceptibility_to2.08262861
27MP0000377_abnormal_hair_follicle2.06702903
28MP0005408_hypopigmentation1.95536943
29MP0003195_calcinosis1.84534601
30MP0008260_abnormal_autophagy1.77169408
31MP0005075_abnormal_melanosome_morpholog1.73247197
32MP0003453_abnormal_keratinocyte_physiol1.72981495
33MP0010329_abnormal_lipoprotein_level1.71273835
34MP0005076_abnormal_cell_differentiation1.70914044
35MP0003878_abnormal_ear_physiology1.70076806
36MP0005377_hearing/vestibular/ear_phenot1.70076806
37MP0002138_abnormal_hepatobiliary_system1.69931914
38MP0004233_abnormal_muscle_weight1.69880367
39MP0003172_abnormal_lysosome_physiology1.68558692
40MP0009931_abnormal_skin_appearance1.67036531
41MP0001191_abnormal_skin_condition1.65504651
42MP0005248_abnormal_Harderian_gland1.57563559
43MP0003638_abnormal_response/metabolism_1.56368534
44MP0000427_abnormal_hair_cycle1.52130820
45MP0003868_abnormal_feces_composition1.51420178
46MP0000609_abnormal_liver_physiology1.50468395
47MP0001835_abnormal_antigen_presentation1.49855185
48MP0003183_abnormal_peptide_metabolism1.46220132
49MP0002166_altered_tumor_susceptibility1.45625977
50MP0003252_abnormal_bile_duct1.40901251
51MP0003806_abnormal_nucleotide_metabolis1.39452500
52MP0006054_spinal_hemorrhage1.38988212
53MP0003436_decreased_susceptibility_to1.36618261
54MP0002396_abnormal_hematopoietic_system1.36606679
55MP0009780_abnormal_chondrocyte_physiolo1.36537132
56MP0002009_preneoplasia1.34420412
57MP0001243_abnormal_dermal_layer1.34160197
58MP0000367_abnormal_coat/_hair1.31204768
59MP0005174_abnormal_tail_pigmentation1.29911740
60MP0001545_abnormal_hematopoietic_system1.27627859
61MP0005397_hematopoietic_system_phenotyp1.27627859
62MP0003566_abnormal_cell_adhesion1.25824783
63MP0009379_abnormal_foot_pigmentation1.22871484
64MP0002118_abnormal_lipid_homeostasis1.22243426
65MP0005025_abnormal_response_to1.22138540
66MP0000467_abnormal_esophagus_morphology1.19831982
67MP0002095_abnormal_skin_pigmentation1.19742846
68MP0004782_abnormal_surfactant_physiolog1.17780382
69MP0005464_abnormal_platelet_physiology1.16076794
70MP0001881_abnormal_mammary_gland1.15456987
71MP0002254_reproductive_system_inflammat1.12873957
72MP0004019_abnormal_vitamin_homeostasis1.11807120
73MP0002006_tumorigenesis1.11335445
74MP0003763_abnormal_thymus_physiology1.10053862
75MP0005000_abnormal_immune_tolerance1.09856325
76MP0002089_abnormal_postnatal_growth/wei1.09805596
77MP0000490_abnormal_crypts_of1.09761093
78MP0002148_abnormal_hypersensitivity_rea1.09497913
79MP0002419_abnormal_innate_immunity1.09092070
80MP0005319_abnormal_enzyme/_coenzyme1.08528212
81MP0004147_increased_porphyrin_level1.07956039
82MP0009785_altered_susceptibility_to1.07834502
83MP0002877_abnormal_melanocyte_morpholog1.06427108
84MP0009672_abnormal_birth_weight1.02460552
85MP0000462_abnormal_digestive_system1.01511080
86MP0001853_heart_inflammation1.01191425
87MP0002723_abnormal_immune_serum0.98358688
88MP0001800_abnormal_humoral_immune0.98029148
89MP0003123_paternal_imprinting0.97674457
90MP0004185_abnormal_adipocyte_glucose0.96626489
91MP0009643_abnormal_urine_homeostasis0.96070623
92MP0002452_abnormal_antigen_presenting0.95448959
93MP0000685_abnormal_immune_system0.95394258
94MP0003656_abnormal_erythrocyte_physiolo0.93966851
95MP0003693_abnormal_embryo_hatching0.93330888
96MP0005666_abnormal_adipose_tissue0.92808170
97MP0002420_abnormal_adaptive_immunity0.92131015
98MP0001819_abnormal_immune_cell0.91483551
99MP0009333_abnormal_splenocyte_physiolog0.90720760
100MP0010155_abnormal_intestine_physiology0.90208564
101MP0005332_abnormal_amino_acid0.89100838
102MP0002909_abnormal_adrenal_gland0.88154166
103MP0000598_abnormal_liver_morphology0.87515069
104MP0005671_abnormal_response_to0.87432995
105MP0001346_abnormal_lacrimal_gland0.85518569
106MP0009840_abnormal_foam_cell0.85068300
107MP0001533_abnormal_skeleton_physiology0.84698561
108MP0002132_abnormal_respiratory_system0.84506816
109MP0001851_eye_inflammation0.83793509
110MP0002398_abnormal_bone_marrow0.83479868
111MP0004808_abnormal_hematopoietic_stem0.79889916
112MP0002876_abnormal_thyroid_physiology0.79705640
113MP0005058_abnormal_lysosome_morphology0.78900673
114MP0004883_abnormal_blood_vessel0.78571251
115MP0003866_abnormal_defecation0.78226060
116MP0005636_abnormal_mineral_homeostasis0.78107207
117MP0002722_abnormal_immune_system0.77473615
118MP0001849_ear_inflammation0.72608018
119MP0001765_abnormal_ion_homeostasis0.72016280
120MP0001727_abnormal_embryo_implantation0.71423412
121MP0001764_abnormal_homeostasis0.71111661
122MP0003011_delayed_dark_adaptation0.70796891
123MP0000716_abnormal_immune_system0.70662390
124MP0003705_abnormal_hypodermis_morpholog0.70118913
125MP0000689_abnormal_spleen_morphology0.69384877
126MP0001845_abnormal_inflammatory_respons0.69104861
127MP0002429_abnormal_blood_cell0.68407751
128MP0005409_darkened_coat_color0.67796250
129MP0001188_hyperpigmentation0.67099682
130MP0000566_synostosis0.66753487
131MP0005584_abnormal_enzyme/coenzyme_acti0.66104604
132MP0000678_abnormal_parathyroid_gland0.66052324
133MP0001873_stomach_inflammation0.64883355
134MP0000627_abnormal_mammary_gland0.64177231
135MP0009642_abnormal_blood_homeostasis0.63295715
136MP0001919_abnormal_reproductive_system0.61469064
137MP0004957_abnormal_blastocyst_morpholog0.61300869
138MP0000762_abnormal_tongue_morphology0.61293976
139MP0003315_abnormal_perineum_morphology0.60813581
140MP0003075_altered_response_to0.60773850
141MP0001790_abnormal_immune_system0.60389916
142MP0005387_immune_system_phenotype0.60389916
143MP0002822_catalepsy0.59342517
144MP0008469_abnormal_protein_level0.59125244
145MP0010352_gastrointestinal_tract_polyps0.57196964
146MP0002019_abnormal_tumor_incidence0.55989402
147MP0010094_abnormal_chromosome_stability0.55600301
148MP0004264_abnormal_extraembryonic_tissu0.52682951
149MP0002405_respiratory_system_inflammati0.51749284
150MP0001784_abnormal_fluid_regulation0.50026017
151MP0000470_abnormal_stomach_morphology0.49665029
152MP0000858_altered_metastatic_potential0.47254002
153MP0003300_gastrointestinal_ulcer0.45740532

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.83952467
2Congenital ichthyosiform erythroderma (HP:0007431)7.13057735
3Deep venous thrombosis (HP:0002625)6.96482600
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.95797269
5Hypotrichosis (HP:0001006)5.78680959
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.38945323
7Abnormality of nail color (HP:0100643)5.28330059
8Erythema (HP:0010783)5.23636830
9Woolly hair (HP:0002224)4.84558441
10Erythroderma (HP:0001019)4.70018045
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.50662980
12Prolonged partial thromboplastin time (HP:0003645)4.35252426
13Eczematoid dermatitis (HP:0000976)4.21695775
14Gangrene (HP:0100758)4.16936698
15Parakeratosis (HP:0001036)4.01578248
16Hypobetalipoproteinemia (HP:0003563)3.97606331
17Ectropion (HP:0000656)3.96469285
18Lip pit (HP:0100267)3.89674745
19Onycholysis (HP:0001806)3.83393441
20Abnormality of cells of the erythroid lineage (HP:0012130)3.79693869
21Abnormal number of erythroid precursors (HP:0012131)3.78736025
22Palmoplantar hyperkeratosis (HP:0000972)3.78603933
23Pili torti (HP:0003777)3.75014819
24Petechiae (HP:0000967)3.73714850
25Pruritus (HP:0000989)3.58978685
26Plantar hyperkeratosis (HP:0007556)3.58557646
27Palmar hyperkeratosis (HP:0010765)3.56414246
28Corneal erosion (HP:0200020)3.54330506
29Joint hemorrhage (HP:0005261)3.53133187
30Menorrhagia (HP:0000132)3.43876239
31J-shaped sella turcica (HP:0002680)3.39724686
32Micronodular cirrhosis (HP:0001413)3.35959245
33Reticulocytopenia (HP:0001896)3.32629374
34Right ventricular cardiomyopathy (HP:0011663)3.23665870
35Abnormality of the common coagulation pathway (HP:0010990)3.12336676
36Recurrent gram-negative bacterial infections (HP:0005420)3.07493932
37Complement deficiency (HP:0004431)3.07182028
38Asymmetry of the thorax (HP:0001555)3.04662509
39Pallor (HP:0000980)3.00485388
40Sparse eyelashes (HP:0000653)2.95863419
41Septate vagina (HP:0001153)2.94907420
42Recurrent bacterial skin infections (HP:0005406)2.93737992
43Abnormal gallbladder physiology (HP:0012438)2.92430080
44Cholecystitis (HP:0001082)2.92430080
45Glomerulonephritis (HP:0000099)2.91094491
46Hypergammaglobulinemia (HP:0010702)2.90139421
47Chronic otitis media (HP:0000389)2.89559101
48Brittle hair (HP:0002299)2.84552559
49Recurrent abscess formation (HP:0002722)2.83278877
50Abnormality of pyrimidine metabolism (HP:0004353)2.82540794
51Vascular calcification (HP:0004934)2.80865881
52Urinary glycosaminoglycan excretion (HP:0003541)2.79954380
53Mucopolysacchariduria (HP:0008155)2.79954380
54Nail dystrophy (HP:0008404)2.77364527
55Elevated erythrocyte sedimentation rate (HP:0003565)2.77184550
56Abnormal blistering of the skin (HP:0008066)2.75627717
57Abnormal hair laboratory examination (HP:0003328)2.74641384
58Thick nail (HP:0001805)2.74319434
59Hemorrhage of the eye (HP:0011885)2.70816529
60Hypohidrosis (HP:0000966)2.70268936
61Thrombocytosis (HP:0001894)2.67586954
62Fragile nails (HP:0001808)2.61360496
63Abnormality of complement system (HP:0005339)2.59775024
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57494574
65Abnormality of polysaccharide metabolism (HP:0011012)2.57494574
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57494574
67Esophageal varix (HP:0002040)2.57339468
68Hyperammonemia (HP:0001987)2.53751719
69Reduced antithrombin III activity (HP:0001976)2.52011768
70Flat acetabular roof (HP:0003180)2.50972130
71Pustule (HP:0200039)2.50125920
72Xanthomatosis (HP:0000991)2.49856566
73Mitral stenosis (HP:0001718)2.49499081
74Distal lower limb muscle weakness (HP:0009053)2.47894346
75Systemic lupus erythematosus (HP:0002725)2.46523951
76Lack of skin elasticity (HP:0100679)2.46360812
77Prolonged bleeding time (HP:0003010)2.46233570
78Abnormality of the axillary hair (HP:0100134)2.45263325
79Abnormality of secondary sexual hair (HP:0009888)2.45263325
80Natal tooth (HP:0000695)2.40435777
81Macrocytic anemia (HP:0001972)2.38708195
82Intrahepatic cholestasis (HP:0001406)2.37218915
83Urticaria (HP:0001025)2.37203810
84Increased serum ferritin (HP:0003281)2.34647197
85Dysostosis multiplex (HP:0000943)2.34120520
86Sparse scalp hair (HP:0002209)2.33536293
87Blepharitis (HP:0000498)2.29657329
88Aplastic anemia (HP:0001915)2.29073368
89Germ cell neoplasia (HP:0100728)2.28940953
90Sepsis (HP:0100806)2.28156312
91Congenital, generalized hypertrichosis (HP:0004540)2.26433155
92Seborrheic dermatitis (HP:0001051)2.26361881
93Palmoplantar keratoderma (HP:0000982)2.26234324
94Cardiovascular calcification (HP:0011915)2.26021759
95Deformed sella turcica (HP:0002681)2.24903636
96Conjugated hyperbilirubinemia (HP:0002908)2.24590489
97Abdominal distention (HP:0003270)2.24542202
98Hypolipoproteinemia (HP:0010981)2.24425245
99Hyperlipoproteinemia (HP:0010980)2.23842140
100Increased neuronal autofluorescent lipopigment (HP:0002074)2.22597250
101Reticulocytosis (HP:0001923)2.21139832
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.20352167
103Vacuolated lymphocytes (HP:0001922)2.19863748
104Skin ulcer (HP:0200042)2.19533293
105Amelogenesis imperfecta (HP:0000705)2.15577711
106Abnormality of small intestinal villus morphology (HP:0011472)2.13118914
107Villous atrophy (HP:0011473)2.13118914
108Dehydration (HP:0001944)2.11702952
109Abnormality of the distal phalanges of the toes (HP:0010182)2.11575381
110Sparse lateral eyebrow (HP:0005338)2.10783017
111Testicular neoplasm (HP:0010788)2.10477950
112Osteolytic defects of the phalanges of the hand (HP:0009771)2.10027904
113Osteolytic defects of the hand bones (HP:0009699)2.10027904
114Epistaxis (HP:0000421)2.07934734
115Interstitial pulmonary disease (HP:0006530)2.06424919
116Widely patent fontanelles and sutures (HP:0004492)2.05235711
117Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02693343
118Areflexia of lower limbs (HP:0002522)2.02587990
119Recurrent skin infections (HP:0001581)2.01720522
120Dry skin (HP:0000958)2.01465940
121Hypophosphatemia (HP:0002148)1.99436172
122Cardiomegaly (HP:0001640)1.99171616
123Abnormality of iron homeostasis (HP:0011031)1.98834396
124Increased cerebral lipofuscin (HP:0011813)1.98714932
125Hypochromic anemia (HP:0001931)1.97923318
126Concave nail (HP:0001598)1.97921447
127Cellulitis (HP:0100658)1.96645946
128Conjunctival hamartoma (HP:0100780)1.96487472
129Hypoparathyroidism (HP:0000829)1.96421168
130Purpura (HP:0000979)1.96239420
131Abnormality of the Achilles tendon (HP:0005109)1.95439676
132Premature ovarian failure (HP:0008209)1.93527688
133Type I transferrin isoform profile (HP:0003642)1.92244795
134Skin rash (HP:0000988)1.91980908
135Curly hair (HP:0002212)1.91823796
136Recurrent fungal infections (HP:0002841)1.90712266
137Periodontitis (HP:0000704)1.89548711
138Acanthosis nigricans (HP:0000956)1.89371800
139Milia (HP:0001056)1.89182888
140Macroorchidism (HP:0000053)1.88940421
141Cervical subluxation (HP:0003308)1.88772011
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87190451
143Abnormality of macrophages (HP:0004311)1.86396711
144Cholelithiasis (HP:0001081)1.85886759
145Abnormal tarsal ossification (HP:0008369)1.85742359
146Oral leukoplakia (HP:0002745)1.85653533
147Hyporeflexia of lower limbs (HP:0002600)1.85632347
148Recurrent viral infections (HP:0004429)1.84807009
149Abnormality of the salivary glands (HP:0010286)1.83667137
150Chronic obstructive pulmonary disease (HP:0006510)1.82517297
151Obstructive lung disease (HP:0006536)1.82517297
152Amyloidosis (HP:0011034)1.82009124
153Thin bony cortex (HP:0002753)1.78750798
154Spontaneous abortion (HP:0005268)1.74952118
155Vertebral compression fractures (HP:0002953)1.74203753
156IgM deficiency (HP:0002850)1.73982851
157Advanced eruption of teeth (HP:0006288)1.73980170
158Gingival bleeding (HP:0000225)1.73780749
159Breast carcinoma (HP:0003002)1.73345400
160Myositis (HP:0100614)1.73252655
161Bone pain (HP:0002653)1.72986445
162Impaired platelet aggregation (HP:0003540)1.72716043
163Abnormal platelet function (HP:0011869)1.72716043
164Abnormal enzyme/coenzyme activity (HP:0012379)1.72709116
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72676924
166Patchy hypopigmentation of hair (HP:0011365)1.72449717
167Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72423505
168Microglossia (HP:0000171)1.71721999
169Abnormality of alkaline phosphatase activity (HP:0004379)1.71701307
170Elevated alkaline phosphatase (HP:0003155)1.70982167
171Ventricular tachycardia (HP:0004756)1.70374307
172Rickets (HP:0002748)1.68551823
173Cheilitis (HP:0100825)1.66710380
174Joint swelling (HP:0001386)1.66704104
175Abnormal gallbladder morphology (HP:0012437)1.66272536
176Abnormality of transition element cation homeostasis (HP:0011030)1.64793821
177Abnormal urine phosphate concentration (HP:0012599)1.64048566
178Hypokinesia (HP:0002375)1.63581580
179Axonal loss (HP:0003447)1.63237530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.91477554
2MST44.09950666
3SIK13.95947781
4MAPKAPK33.89829970
5NME23.38431497
6PKN22.81042185
7RPS6KB22.73178127
8PIM22.56806037
9TNIK2.56647194
10IRAK32.51418829
11GRK62.42956135
12BLK2.40451449
13FGFR42.34440687
14MAP3K32.31439884
15SMG12.26403115
16STK162.19013154
17TEC2.15829102
18TESK22.04561359
19MAPKAPK51.98504173
20LMTK21.98023165
21KIT1.97333395
22DYRK31.95912363
23EEF2K1.87911426
24TAOK31.82338010
25NEK91.82043363
26MAP2K31.81118212
27IRAK41.75331090
28CDK191.71590876
29TIE11.63026114
30WEE11.62758216
31TRPM71.60481876
32BTK1.54715455
33TYK21.53471843
34SIK31.52942566
35EPHB11.52482642
36RIPK11.48884245
37PAK41.45860953
38EIF2AK11.45202786
39TESK11.43571455
40ERN11.43130275
41MATK1.40978361
42ICK1.34224768
43EIF2AK31.29138547
44NLK1.27213723
45LRRK21.26342099
46TBK11.24307614
47MST1R1.23326346
48STK101.22825438
49JAK31.20167378
50TAOK11.16616568
51IKBKE1.14853403
52PDPK11.12451076
53MAP4K11.10386451
54RET1.10277528
55EPHA21.08663664
56MAP3K141.07847523
57IKBKB1.07279419
58PIK3CA1.06520772
59PIK3CG1.06201772
60MAP3K111.05060985
61SRPK11.04138722
62SYK1.03841448
63GRK10.97328202
64STK30.96820297
65CDK120.96343344
66NME10.94757575
67MAP2K10.94597335
68SCYL20.92005737
69MAP3K120.91491066
70PRPF4B0.90884948
71KSR20.88935548
72FGFR30.86953498
73BRSK20.86934709
74PRKG20.84808151
75PRKCI0.82745340
76NEK60.79897361
77ITK0.78119756
78DMPK0.77801426
79PRKD20.77766120
80FER0.77131678
81RIPK40.76550178
82EIF2AK20.74445797
83MAP3K20.74334897
84CHUK0.74273402
85PDK10.70165739
86RPS6KA40.70067993
87MAP3K10.69987945
88CDK70.69986965
89YES10.69322832
90MKNK10.67868280
91IRAK20.67507142
92MTOR0.66867637
93CLK10.66423272
94PIM10.65809499
95MAP3K60.65474890
96TNK20.64765296
97MAPK40.64736601
98LYN0.64403180
99MAPKAPK20.63297077
100TGFBR10.63198010
101HCK0.62078333
102HIPK20.61718432
103ILK0.61510740
104DYRK1B0.60841017
105VRK10.60155782
106STK380.59586311
107MAP2K20.59302193
108ZAP700.59137127
109MAP3K100.58889763
110RPS6KA20.58528018
111TGFBR20.58159469
112RPS6KB10.57139135
113MARK20.56051372
114LCK0.53392900
115TLK10.52713441
116BCKDK0.52457953
117RPS6KC10.52103603
118RPS6KL10.52103603
119PTK20.50496113
120CSK0.50447423
121JAK10.49815914
122CDK60.49077450
123PBK0.48966884
124RPS6KA60.47724877
125NEK20.47455895
126CSF1R0.46998541
127JAK20.46550611
128MAP2K60.46354462
129MAP2K40.46193512
130STK240.46076493
131BMPR1B0.45933523
132AKT30.45877661
133CAMK2G0.45485395
134AURKB0.44559003
135ABL20.44252256
136TAOK20.43744994
137CDK40.43541878
138ZAK0.42595273
139MUSK0.42309116
140SGK30.42112809
141TTN0.41483971
142FGFR20.41471124
143PRKD10.41361219
144AURKA0.40474558
145STK40.39719580
146LATS10.38375387
147KDR0.37666161
148PRKCZ0.37377184
149VRK20.37287335
150MAPK110.36012860
151PAK20.35689663
152PTK60.35340707
153PRKAA20.33456855
154MAP3K90.30307024
155CAMK2B0.30243573
156MARK30.29525355
157BMX0.27018556
158ALK0.25737348

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.04150862
2Sphingolipid metabolism_Homo sapiens_hsa006003.15107511
3Complement and coagulation cascades_Homo sapiens_hsa046103.08636032
4DNA replication_Homo sapiens_hsa030302.80991175
5Phenylalanine metabolism_Homo sapiens_hsa003602.48050323
6Arachidonic acid metabolism_Homo sapiens_hsa005902.37408889
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35721570
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.29947594
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.29405034
10Proteasome_Homo sapiens_hsa030502.28333573
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18249106
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10912225
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.09880245
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.04844279
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.03349257
16Chemical carcinogenesis_Homo sapiens_hsa052042.03321143
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.02076575
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.01998446
19Arginine biosynthesis_Homo sapiens_hsa002202.00807393
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96778258
21ABC transporters_Homo sapiens_hsa020101.92493114
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.90364140
23Retinol metabolism_Homo sapiens_hsa008301.85079316
24Caffeine metabolism_Homo sapiens_hsa002321.83399905
25Linoleic acid metabolism_Homo sapiens_hsa005911.76942211
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76254629
27Other glycan degradation_Homo sapiens_hsa005111.71909271
28Mismatch repair_Homo sapiens_hsa034301.64992874
29Hematopoietic cell lineage_Homo sapiens_hsa046401.63302266
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60433683
31Bile secretion_Homo sapiens_hsa049761.59095272
32Staphylococcus aureus infection_Homo sapiens_hsa051501.53877214
33Leishmaniasis_Homo sapiens_hsa051401.53353915
34Tyrosine metabolism_Homo sapiens_hsa003501.50954185
35Base excision repair_Homo sapiens_hsa034101.49087148
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48084003
37Acute myeloid leukemia_Homo sapiens_hsa052211.47038407
38Herpes simplex infection_Homo sapiens_hsa051681.46610325
39Measles_Homo sapiens_hsa051621.45591467
40Lysosome_Homo sapiens_hsa041421.44715435
41Antigen processing and presentation_Homo sapiens_hsa046121.44674592
42Pertussis_Homo sapiens_hsa051331.42208349
43Protein export_Homo sapiens_hsa030601.42051646
44Fructose and mannose metabolism_Homo sapiens_hsa000511.40760756
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39846734
46Fatty acid elongation_Homo sapiens_hsa000621.38877615
47Folate biosynthesis_Homo sapiens_hsa007901.38462573
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38408498
49Homologous recombination_Homo sapiens_hsa034401.34839742
50PPAR signaling pathway_Homo sapiens_hsa033201.33672801
51Galactose metabolism_Homo sapiens_hsa000521.32487633
52Fatty acid degradation_Homo sapiens_hsa000711.31632496
53RNA polymerase_Homo sapiens_hsa030201.29868981
54Starch and sucrose metabolism_Homo sapiens_hsa005001.29795693
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28789423
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.24588213
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22311312
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18742321
59Histidine metabolism_Homo sapiens_hsa003401.18124399
60Endometrial cancer_Homo sapiens_hsa052131.17628270
61Sulfur relay system_Homo sapiens_hsa041221.16465869
62SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16109412
63B cell receptor signaling pathway_Homo sapiens_hsa046621.15961305
64Platelet activation_Homo sapiens_hsa046111.15888400
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15110883
66p53 signaling pathway_Homo sapiens_hsa041151.13527364
67Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13335921
68Insulin resistance_Homo sapiens_hsa049311.11568275
69Non-small cell lung cancer_Homo sapiens_hsa052231.11453237
70Biosynthesis of amino acids_Homo sapiens_hsa012301.10988560
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.10220569
72Pyrimidine metabolism_Homo sapiens_hsa002401.09989725
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.09103588
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08568535
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08269309
76Non-homologous end-joining_Homo sapiens_hsa034501.07893480
77Ether lipid metabolism_Homo sapiens_hsa005651.07157528
78Osteoclast differentiation_Homo sapiens_hsa043801.05700438
79Tuberculosis_Homo sapiens_hsa051521.05353645
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03382981
81Primary immunodeficiency_Homo sapiens_hsa053401.02917599
82Legionellosis_Homo sapiens_hsa051341.01914102
83Insulin signaling pathway_Homo sapiens_hsa049101.01483510
84Leukocyte transendothelial migration_Homo sapiens_hsa046701.01072417
85Spliceosome_Homo sapiens_hsa030401.00443980
86AMPK signaling pathway_Homo sapiens_hsa041520.99666952
87Fatty acid metabolism_Homo sapiens_hsa012120.99665187
88Carbon metabolism_Homo sapiens_hsa012000.99592658
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98837480
90Hepatitis C_Homo sapiens_hsa051600.97292657
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.95717392
92Peroxisome_Homo sapiens_hsa041460.95553723
93Apoptosis_Homo sapiens_hsa042100.95494298
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95467016
95Epstein-Barr virus infection_Homo sapiens_hsa051690.92619881
96Thyroid cancer_Homo sapiens_hsa052160.92563210
97Steroid biosynthesis_Homo sapiens_hsa001000.88149657
98Pentose phosphate pathway_Homo sapiens_hsa000300.87804076
99Renal cell carcinoma_Homo sapiens_hsa052110.84699018
100Influenza A_Homo sapiens_hsa051640.84604503
101Vitamin digestion and absorption_Homo sapiens_hsa049770.81864464
102Toxoplasmosis_Homo sapiens_hsa051450.80958556
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79044334
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78965539
105Vibrio cholerae infection_Homo sapiens_hsa051100.76200092
106beta-Alanine metabolism_Homo sapiens_hsa004100.74568475
107mTOR signaling pathway_Homo sapiens_hsa041500.74477662
108Fanconi anemia pathway_Homo sapiens_hsa034600.74018973
109Nucleotide excision repair_Homo sapiens_hsa034200.71783136
110Malaria_Homo sapiens_hsa051440.70739820
111Prolactin signaling pathway_Homo sapiens_hsa049170.70133913
112Choline metabolism in cancer_Homo sapiens_hsa052310.70067660
113Glutathione metabolism_Homo sapiens_hsa004800.69109994
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68901990
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.68153932
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66021395
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65841287
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65712221
119Inositol phosphate metabolism_Homo sapiens_hsa005620.65175439
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64990293
121Hepatitis B_Homo sapiens_hsa051610.64344203
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63006475
123Rheumatoid arthritis_Homo sapiens_hsa053230.61868330
124Cell cycle_Homo sapiens_hsa041100.61507585
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61422089
126Salmonella infection_Homo sapiens_hsa051320.60767902
127Fat digestion and absorption_Homo sapiens_hsa049750.60042975
128Pancreatic cancer_Homo sapiens_hsa052120.58267562
129Viral carcinogenesis_Homo sapiens_hsa052030.57241698
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57014890
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56551240
132Prion diseases_Homo sapiens_hsa050200.56503428
133Asthma_Homo sapiens_hsa053100.56082859
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54226042
135ErbB signaling pathway_Homo sapiens_hsa040120.53607313
136Fatty acid biosynthesis_Homo sapiens_hsa000610.53271644
137Phagosome_Homo sapiens_hsa041450.53195904
138Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52640762
139TNF signaling pathway_Homo sapiens_hsa046680.51614315
140Bladder cancer_Homo sapiens_hsa052190.51279894
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50198948
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49936321
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49754645
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.49428584
145Small cell lung cancer_Homo sapiens_hsa052220.48411915
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48345500
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48280934
148Shigellosis_Homo sapiens_hsa051310.46601320
149Arginine and proline metabolism_Homo sapiens_hsa003300.45977281
150Tryptophan metabolism_Homo sapiens_hsa003800.44648241
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42502988
152HTLV-I infection_Homo sapiens_hsa051660.42415584
153Butanoate metabolism_Homo sapiens_hsa006500.42376842
154Glucagon signaling pathway_Homo sapiens_hsa049220.42065286
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40829424
156Pyruvate metabolism_Homo sapiens_hsa006200.40547786
157One carbon pool by folate_Homo sapiens_hsa006700.40168276
158Renin-angiotensin system_Homo sapiens_hsa046140.38135706
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.36963312
160Amoebiasis_Homo sapiens_hsa051460.36803282
161Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36078650
162Graft-versus-host disease_Homo sapiens_hsa053320.35043996
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34763198
164Endocytosis_Homo sapiens_hsa041440.34752742
165RNA transport_Homo sapiens_hsa030130.34387669
166N-Glycan biosynthesis_Homo sapiens_hsa005100.33949041
167Purine metabolism_Homo sapiens_hsa002300.33563202
168RNA degradation_Homo sapiens_hsa030180.31524430
169VEGF signaling pathway_Homo sapiens_hsa043700.30014634
170Chronic myeloid leukemia_Homo sapiens_hsa052200.24279138

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