Rank | Gene Set | Z-score |
---|---|---|
1 | modulation by symbiont of host defense response (GO:0052031) | 6.92339592 |
2 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 6.92339592 |
3 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 6.92339592 |
4 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 6.92339592 |
5 | modulation by symbiont of host immune response (GO:0052553) | 6.92339592 |
6 | positive regulation by symbiont of host defense response (GO:0052509) | 6.92339592 |
7 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.03055695 |
8 | negative regulation of cell killing (GO:0031342) | 6.03055695 |
9 | response to peptidoglycan (GO:0032494) | 5.87633968 |
10 | neutrophil activation involved in immune response (GO:0002283) | 5.64123125 |
11 | positive regulation of interferon-alpha production (GO:0032727) | 5.50844407 |
12 | regulation of interferon-alpha production (GO:0032647) | 5.30907985 |
13 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.11791542 |
14 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.90564051 |
15 | immunoglobulin mediated immune response (GO:0016064) | 4.89467212 |
16 | macrophage activation involved in immune response (GO:0002281) | 4.87132546 |
17 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 4.85073645 |
18 | response to host immune response (GO:0052572) | 4.76262492 |
19 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 4.76262492 |
20 | respiratory burst (GO:0045730) | 4.72519664 |
21 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.61112954 |
22 | regulation of gamma-delta T cell activation (GO:0046643) | 4.58080421 |
23 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.47454909 |
24 | detection of bacterium (GO:0016045) | 4.44253580 |
25 | hydrogen peroxide biosynthetic process (GO:0050665) | 4.31225924 |
26 | microglial cell activation (GO:0001774) | 4.20147724 |
27 | response to host (GO:0075136) | 4.19918217 |
28 | response to host defenses (GO:0052200) | 4.19918217 |
29 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 4.19918217 |
30 | detection of external biotic stimulus (GO:0098581) | 4.17508995 |
31 | superoxide anion generation (GO:0042554) | 4.15951990 |
32 | granulocyte activation (GO:0036230) | 4.13626675 |
33 | eosinophil chemotaxis (GO:0048245) | 4.07075444 |
34 | positive regulation of chemokine biosynthetic process (GO:0045080) | 4.07041825 |
35 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.06700216 |
36 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 4.06687176 |
37 | neutrophil activation (GO:0042119) | 4.05383001 |
38 | reactive oxygen species biosynthetic process (GO:1903409) | 4.04704884 |
39 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.01928223 |
40 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.97983934 |
41 | positive regulation of interferon-beta production (GO:0032728) | 3.95884833 |
42 | cellular response to type I interferon (GO:0071357) | 3.93628177 |
43 | type I interferon signaling pathway (GO:0060337) | 3.93628177 |
44 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.89251418 |
45 | response to type I interferon (GO:0034340) | 3.89189147 |
46 | positive regulation of cellular amide metabolic process (GO:0034250) | 3.88497345 |
47 | response to muramyl dipeptide (GO:0032495) | 3.85170304 |
48 | detection of biotic stimulus (GO:0009595) | 3.80252662 |
49 | B cell mediated immunity (GO:0019724) | 3.78706543 |
50 | negative regulation of T cell mediated immunity (GO:0002710) | 3.78504118 |
51 | macrophage activation (GO:0042116) | 3.73904399 |
52 | eosinophil migration (GO:0072677) | 3.69825086 |
53 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.62506405 |
54 | natural killer cell mediated immunity (GO:0002228) | 3.60774935 |
55 | natural killer cell mediated cytotoxicity (GO:0042267) | 3.60774935 |
56 | positive regulation of heat generation (GO:0031652) | 3.59133293 |
57 | myeloid cell activation involved in immune response (GO:0002275) | 3.57655590 |
58 | production of molecular mediator involved in inflammatory response (GO:0002532) | 3.56472523 |
59 | response to interferon-alpha (GO:0035455) | 3.54885695 |
60 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.53426952 |
61 | positive regulation of antigen processing and presentation (GO:0002579) | 3.50887980 |
62 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.46441317 |
63 | regulation of chemokine biosynthetic process (GO:0045073) | 3.46311343 |
64 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.42947302 |
65 | regulation of mononuclear cell migration (GO:0071675) | 3.42839219 |
66 | neutrophil mediated immunity (GO:0002446) | 3.40269755 |
67 | cellular extravasation (GO:0045123) | 3.39833903 |
68 | negative regulation of interleukin-12 production (GO:0032695) | 3.36797205 |
69 | detection of molecule of bacterial origin (GO:0032490) | 3.33824237 |
70 | lymphocyte chemotaxis (GO:0048247) | 3.33100538 |
71 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.32547558 |
72 | positive thymic T cell selection (GO:0045059) | 3.32317399 |
73 | leukocyte mediated cytotoxicity (GO:0001909) | 3.31538643 |
74 | positive regulation of B cell differentiation (GO:0045579) | 3.31422078 |
75 | positive regulation of mast cell activation (GO:0033005) | 3.28999434 |
76 | regulation of tolerance induction (GO:0002643) | 3.28872838 |
77 | regulation of fever generation (GO:0031620) | 3.28238503 |
78 | response to interleukin-15 (GO:0070672) | 3.27537567 |
79 | regulation of T cell tolerance induction (GO:0002664) | 3.26148653 |
80 | negative T cell selection (GO:0043383) | 3.25966035 |
81 | negative thymic T cell selection (GO:0045060) | 3.25594644 |
82 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.24173192 |
83 | negative regulation of erythrocyte differentiation (GO:0045647) | 3.24073092 |
84 | activated T cell proliferation (GO:0050798) | 3.24054725 |
85 | negative regulation of viral genome replication (GO:0045071) | 3.22615893 |
86 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.22571241 |
87 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 3.22285370 |
88 | positive regulation of mast cell degranulation (GO:0043306) | 3.22285370 |
89 | leukocyte aggregation (GO:0070486) | 3.22220177 |
90 | regulation of mast cell degranulation (GO:0043304) | 3.22139989 |
91 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.20379376 |
92 | T cell migration (GO:0072678) | 3.19575463 |
93 | B cell receptor signaling pathway (GO:0050853) | 3.17572677 |
94 | monocyte chemotaxis (GO:0002548) | 3.15738968 |
95 | regulation of B cell differentiation (GO:0045577) | 3.14573509 |
96 | myeloid leukocyte mediated immunity (GO:0002444) | 3.13315527 |
97 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.12022991 |
98 | I-kappaB phosphorylation (GO:0007252) | 3.10582882 |
99 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.09787346 |
100 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.07314145 |
101 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 3.06293626 |
102 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.06040924 |
103 | leukocyte migration involved in inflammatory response (GO:0002523) | 3.05535524 |
104 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 3.05106389 |
105 | leukocyte degranulation (GO:0043299) | 3.04295745 |
106 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.03663375 |
107 | regulation of mast cell activation involved in immune response (GO:0033006) | 3.03588735 |
108 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.03518998 |
109 | germinal center formation (GO:0002467) | 3.03044926 |
110 | cellular response to interleukin-15 (GO:0071350) | 3.02166728 |
111 | response to protozoan (GO:0001562) | 3.02041660 |
112 | defense response to protozoan (GO:0042832) | 3.01298312 |
113 | regulation of antigen processing and presentation (GO:0002577) | 3.00197870 |
114 | cellular response to virus (GO:0098586) | 3.00060045 |
115 | NIK/NF-kappaB signaling (GO:0038061) | 2.98469597 |
116 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.97520255 |
117 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.97520255 |
118 | regulation of mast cell activation (GO:0033003) | 2.96169450 |
119 | positive T cell selection (GO:0043368) | 2.96150398 |
120 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 2.95594290 |
121 | positive regulation of myeloid leukocyte mediated immunity (GO:0002888) | 2.94968670 |
122 | pinocytosis (GO:0006907) | 2.94004312 |
123 | regulation of leukocyte degranulation (GO:0043300) | 2.92868436 |
124 | T cell selection (GO:0045058) | 2.92591268 |
125 | interferon-gamma production (GO:0032609) | 2.91737499 |
126 | regulation of alpha-beta T cell proliferation (GO:0046640) | 2.91004390 |
127 | lymphocyte mediated immunity (GO:0002449) | 2.90778352 |
128 | cellular response to interferon-beta (GO:0035458) | 2.90459743 |
129 | positive regulation of lymphocyte migration (GO:2000403) | 2.89253350 |
130 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 2.89249073 |
131 | positive regulation of monocyte chemotaxis (GO:0090026) | 2.88507752 |
132 | T-helper 1 type immune response (GO:0042088) | 2.86986209 |
133 | regulation of myeloid leukocyte mediated immunity (GO:0002886) | 2.86323234 |
134 | response to interferon-beta (GO:0035456) | 2.85576732 |
135 | positive regulation of leukocyte degranulation (GO:0043302) | 2.84909364 |
136 | regulation of interferon-beta production (GO:0032648) | 2.84229547 |
137 | detection of other organism (GO:0098543) | 2.83196255 |
138 | basic amino acid transport (GO:0015802) | 2.82542465 |
139 | myeloid leukocyte activation (GO:0002274) | 2.82335727 |
140 | positive regulation of interleukin-1 secretion (GO:0050716) | 2.81961049 |
141 | neutrophil migration (GO:1990266) | 2.81501523 |
142 | neutrophil chemotaxis (GO:0030593) | 2.80312002 |
143 | cellular response to interferon-gamma (GO:0071346) | 2.78641963 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 7.60128810 |
2 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.63636757 |
3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 6.01999219 |
4 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.72595772 |
5 | * SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 4.34315764 |
6 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.30209414 |
7 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.20664694 |
8 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.89512631 |
9 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.60776273 |
10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.29012636 |
11 | * MYB_21317192_ChIP-Seq_ERMYB_Mouse | 3.13975105 |
12 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.99755910 |
13 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.85073503 |
14 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.69702805 |
15 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.60367665 |
16 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.53752608 |
17 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.52411201 |
18 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.48373808 |
19 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.37637020 |
20 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.31246717 |
21 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 2.25375126 |
22 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.98836574 |
23 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.96396602 |
24 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.91169477 |
25 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.87815668 |
26 | * PU_27001747_Chip-Seq_BMDM_Mouse | 1.79710138 |
27 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.73594674 |
28 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.72781060 |
29 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.71825005 |
30 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71813567 |
31 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.67615789 |
32 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.63417647 |
33 | SPI1_23127762_ChIP-Seq_K562_Human | 1.62846379 |
34 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.61842833 |
35 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.53214237 |
36 | * PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.50952780 |
37 | MYB_26560356_Chip-Seq_TH2_Human | 1.50114943 |
38 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.49697164 |
39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45471083 |
40 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.44101844 |
41 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.43598993 |
42 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.43141975 |
43 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.42785074 |
44 | * MAF_26560356_Chip-Seq_TH1_Human | 1.39959978 |
45 | MYB_26560356_Chip-Seq_TH1_Human | 1.36806227 |
46 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.35609120 |
47 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.33397135 |
48 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.32123974 |
49 | GATA1_22025678_ChIP-Seq_K562_Human | 1.29911391 |
50 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27349173 |
51 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.25246918 |
52 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.24503064 |
53 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.24272172 |
54 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.20996471 |
55 | GATA3_26560356_Chip-Seq_TH2_Human | 1.20350509 |
56 | GATA1_19941826_ChIP-Seq_K562_Human | 1.17834648 |
57 | * GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.16638562 |
58 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.15088417 |
59 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.13764742 |
60 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.12988244 |
61 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.12610736 |
62 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12119463 |
63 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.11879687 |
64 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.09745410 |
65 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.06109694 |
66 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.03929216 |
67 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.03886446 |
68 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.03548911 |
69 | UTX_26944678_Chip-Seq_JUKART_Human | 1.03050937 |
70 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.02947783 |
71 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.02303553 |
72 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.01976046 |
73 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.01697179 |
74 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.99374752 |
75 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.99079139 |
76 | GATA2_19941826_ChIP-Seq_K562_Human | 0.97873789 |
77 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.96712602 |
78 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.93679039 |
79 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.92752515 |
80 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.90891058 |
81 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.89375635 |
82 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 0.86998963 |
83 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.86593497 |
84 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.85806568 |
85 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.82808273 |
86 | * RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81098166 |
87 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.80825291 |
88 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.80662683 |
89 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.80185462 |
90 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.80041472 |
91 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.78953296 |
92 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.78037216 |
93 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.77615352 |
94 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.76807943 |
95 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.75693173 |
96 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.74127032 |
97 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.71662448 |
98 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.71639042 |
99 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.71315242 |
100 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.71027950 |
101 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.69240262 |
102 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.69195462 |
103 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.68868978 |
104 | MAF_26560356_Chip-Seq_TH2_Human | 0.68229191 |
105 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.67443550 |
106 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.65965838 |
107 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.63712450 |
108 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.62255120 |
109 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.59214731 |
110 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.57112062 |
111 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.56967617 |
112 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.56260850 |
113 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.56027425 |
114 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.55767453 |
115 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 0.55545323 |
116 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.55308404 |
117 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.55021290 |
118 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.55021290 |
119 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.55021290 |
120 | MYC_22102868_ChIP-Seq_BL_Human | 0.54646685 |
121 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.54002792 |
122 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.53984042 |
123 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.53380463 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0001835_abnormal_antigen_presentation | 4.18089554 |
2 | MP0005058_abnormal_lysosome_morphology | 3.80783793 |
3 | MP0009785_altered_susceptibility_to | 3.76370495 |
4 | MP0003436_decreased_susceptibility_to | 3.67506499 |
5 | MP0003303_peritoneal_inflammation | 3.42099916 |
6 | MP0002419_abnormal_innate_immunity | 3.27386805 |
7 | MP0002148_abnormal_hypersensitivity_rea | 3.19725662 |
8 | MP0006082_CNS_inflammation | 3.09832976 |
9 | MP0005000_abnormal_immune_tolerance | 2.95938577 |
10 | MP0005025_abnormal_response_to | 2.94990390 |
11 | MP0003724_increased_susceptibility_to | 2.91669075 |
12 | MP0001790_abnormal_immune_system | 2.71880218 |
13 | MP0005387_immune_system_phenotype | 2.71880218 |
14 | MP0005671_abnormal_response_to | 2.57210189 |
15 | MP0002452_abnormal_antigen_presenting | 2.50425237 |
16 | MP0003172_abnormal_lysosome_physiology | 2.47978438 |
17 | * MP0001800_abnormal_humoral_immune | 2.36676933 |
18 | MP0002723_abnormal_immune_serum | 2.34637633 |
19 | MP0009840_abnormal_foam_cell | 2.33741168 |
20 | MP0000685_abnormal_immune_system | 2.23804443 |
21 | MP0001533_abnormal_skeleton_physiology | 2.11712258 |
22 | MP0000343_altered_response_to | 2.09826137 |
23 | MP0003763_abnormal_thymus_physiology | 2.08631292 |
24 | MP0001819_abnormal_immune_cell | 2.07418179 |
25 | MP0004510_myositis | 2.06808144 |
26 | MP0002420_abnormal_adaptive_immunity | 2.04581823 |
27 | MP0005464_abnormal_platelet_physiology | 2.01479997 |
28 | MP0009764_decreased_sensitivity_to | 2.00201836 |
29 | MP0004947_skin_inflammation | 1.91860861 |
30 | MP0001845_abnormal_inflammatory_respons | 1.90905560 |
31 | MP0002405_respiratory_system_inflammati | 1.89946555 |
32 | MP0003075_altered_response_to | 1.87468992 |
33 | MP0009278_abnormal_bone_marrow | 1.84168188 |
34 | MP0000569_abnormal_digit_pigmentation | 1.83077945 |
35 | MP0008469_abnormal_protein_level | 1.82033971 |
36 | MP0003448_altered_tumor_morphology | 1.81996882 |
37 | MP0001853_heart_inflammation | 1.75858988 |
38 | MP0000604_amyloidosis | 1.75498192 |
39 | MP0003186_abnormal_redox_activity | 1.63567396 |
40 | MP0005310_abnormal_salivary_gland | 1.57474028 |
41 | MP0010155_abnormal_intestine_physiology | 1.57469360 |
42 | MP0005451_abnormal_body_composition | 1.50052616 |
43 | MP0000465_gastrointestinal_hemorrhage | 1.50047478 |
44 | MP0002998_abnormal_bone_remodeling | 1.48221887 |
45 | MP0000716_abnormal_immune_system | 1.46662523 |
46 | MP0003690_abnormal_glial_cell | 1.46325219 |
47 | MP0000858_altered_metastatic_potential | 1.45675577 |
48 | MP0003866_abnormal_defecation | 1.43905943 |
49 | MP0005167_abnormal_blood-brain_barrier | 1.43391077 |
50 | MP0010307_abnormal_tumor_latency | 1.39718509 |
51 | MP0002277_abnormal_respiratory_mucosa | 1.38226069 |
52 | MP0002398_abnormal_bone_marrow | 1.33192378 |
53 | MP0002132_abnormal_respiratory_system | 1.33094770 |
54 | MP0002006_tumorigenesis | 1.32411269 |
55 | MP0000689_abnormal_spleen_morphology | 1.29686087 |
56 | MP0005166_decreased_susceptibility_to | 1.26939982 |
57 | MP0009333_abnormal_splenocyte_physiolog | 1.25173948 |
58 | MP0000703_abnormal_thymus_morphology | 1.25119816 |
59 | MP0001545_abnormal_hematopoietic_system | 1.23542069 |
60 | MP0005397_hematopoietic_system_phenotyp | 1.23542069 |
61 | MP0003191_abnormal_cellular_cholesterol | 1.23019147 |
62 | MP0002429_abnormal_blood_cell | 1.21586270 |
63 | MP0003183_abnormal_peptide_metabolism | 1.20145236 |
64 | MP0003300_gastrointestinal_ulcer | 1.18535396 |
65 | MP0003195_calcinosis | 1.18497327 |
66 | MP0005164_abnormal_response_to | 1.17637975 |
67 | MP0002722_abnormal_immune_system | 1.14346794 |
68 | MP0004381_abnormal_hair_follicle | 1.11528182 |
69 | MP0009763_increased_sensitivity_to | 1.08112188 |
70 | MP0002136_abnormal_kidney_physiology | 1.04750601 |
71 | MP0004782_abnormal_surfactant_physiolog | 1.02757121 |
72 | MP0002138_abnormal_hepatobiliary_system | 1.01249888 |
73 | MP0003566_abnormal_cell_adhesion | 1.00266386 |
74 | MP0005174_abnormal_tail_pigmentation | 0.97881835 |
75 | MP0008260_abnormal_autophagy | 0.95551381 |
76 | MP0002166_altered_tumor_susceptibility | 0.95132526 |
77 | MP0004858_abnormal_nervous_system | 0.93767112 |
78 | MP0003828_pulmonary_edema | 0.93164392 |
79 | MP0010352_gastrointestinal_tract_polyps | 0.91323155 |
80 | MP0002254_reproductive_system_inflammat | 0.91102486 |
81 | MP0005390_skeleton_phenotype | 0.90423482 |
82 | MP0003806_abnormal_nucleotide_metabolis | 0.87714935 |
83 | MP0005076_abnormal_cell_differentiation | 0.87127876 |
84 | MP0000371_diluted_coat_color | 0.86776890 |
85 | MP0001663_abnormal_digestive_system | 0.84083884 |
86 | MP0002332_abnormal_exercise_endurance | 0.83857487 |
87 | MP0005075_abnormal_melanosome_morpholog | 0.82092826 |
88 | MP0000015_abnormal_ear_pigmentation | 0.79937712 |
89 | MP0009643_abnormal_urine_homeostasis | 0.79524269 |
90 | MP0004019_abnormal_vitamin_homeostasis | 0.79382158 |
91 | MP0001873_stomach_inflammation | 0.78263745 |
92 | MP0005319_abnormal_enzyme/_coenzyme | 0.77346776 |
93 | MP0005023_abnormal_wound_healing | 0.76149151 |
94 | MP0003795_abnormal_bone_structure | 0.74840843 |
95 | MP0001851_eye_inflammation | 0.73152056 |
96 | MP0002933_joint_inflammation | 0.73037598 |
97 | MP0009765_abnormal_xenobiotic_induced | 0.72635975 |
98 | MP0004883_abnormal_blood_vessel | 0.71789524 |
99 | MP0008004_abnormal_stomach_pH | 0.71334062 |
100 | MP0003656_abnormal_erythrocyte_physiolo | 0.71086604 |
101 | MP0000249_abnormal_blood_vessel | 0.71044662 |
102 | MP0001986_abnormal_taste_sensitivity | 0.70466191 |
103 | MP0002396_abnormal_hematopoietic_system | 0.68398493 |
104 | MP0003045_fibrosis | 0.67459627 |
105 | MP0003453_abnormal_keratinocyte_physiol | 0.65160246 |
106 | MP0001958_emphysema | 0.65154210 |
107 | MP0002009_preneoplasia | 0.63512562 |
108 | MP0000920_abnormal_myelination | 0.62319664 |
109 | MP0008874_decreased_physiological_sensi | 0.60936365 |
110 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.59590757 |
111 | MP0000609_abnormal_liver_physiology | 0.59066348 |
112 | MP0006054_spinal_hemorrhage | 0.58574824 |
113 | MP0000490_abnormal_crypts_of | 0.56881441 |
114 | MP0005083_abnormal_biliary_tract | 0.56768660 |
115 | MP0004808_abnormal_hematopoietic_stem | 0.56764345 |
116 | MP0008873_increased_physiological_sensi | 0.56697533 |
117 | MP0005332_abnormal_amino_acid | 0.55487757 |
118 | MP0003329_amyloid_beta_deposits | 0.54061347 |
119 | MP0004130_abnormal_muscle_cell | 0.53993582 |
120 | MP0003091_abnormal_cell_migration | 0.53780338 |
121 | MP0003221_abnormal_cardiomyocyte_apopto | 0.52582899 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Recurrent abscess formation (HP:0002722) | 7.69178423 |
2 | Recurrent bacterial skin infections (HP:0005406) | 6.93712135 |
3 | Eczematoid dermatitis (HP:0000976) | 6.82255141 |
4 | Recurrent gram-negative bacterial infections (HP:0005420) | 5.74527239 |
5 | Systemic lupus erythematosus (HP:0002725) | 5.57799372 |
6 | Abnormality of macrophages (HP:0004311) | 5.50959103 |
7 | Mediastinal lymphadenopathy (HP:0100721) | 4.90178553 |
8 | Vacuolated lymphocytes (HP:0001922) | 4.77997736 |
9 | Stomatitis (HP:0010280) | 4.49384146 |
10 | Autoimmune thrombocytopenia (HP:0001973) | 4.44411147 |
11 | Increased cerebral lipofuscin (HP:0011813) | 4.27587397 |
12 | Orchitis (HP:0100796) | 4.13589631 |
13 | Gingivitis (HP:0000230) | 4.08126151 |
14 | Myositis (HP:0100614) | 3.95941621 |
15 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.95209335 |
16 | Recurrent skin infections (HP:0001581) | 3.92310831 |
17 | Prostate neoplasm (HP:0100787) | 3.87338724 |
18 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.87256048 |
19 | T lymphocytopenia (HP:0005403) | 3.83568190 |
20 | Retrobulbar optic neuritis (HP:0100654) | 3.81844445 |
21 | Optic neuritis (HP:0100653) | 3.81844445 |
22 | Gastrointestinal infarctions (HP:0005244) | 3.81045514 |
23 | Obstructive lung disease (HP:0006536) | 3.75261244 |
24 | Chronic obstructive pulmonary disease (HP:0006510) | 3.75261244 |
25 | Glomerulonephritis (HP:0000099) | 3.61611355 |
26 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.61507624 |
27 | Abnormality of T cell number (HP:0011839) | 3.61260643 |
28 | Axonal loss (HP:0003447) | 3.48954876 |
29 | Recurrent fungal infections (HP:0002841) | 3.44488800 |
30 | Recurrent viral infections (HP:0004429) | 3.33314065 |
31 | Disinhibition (HP:0000734) | 3.30651292 |
32 | Dysostosis multiplex (HP:0000943) | 3.17021892 |
33 | Amyloidosis (HP:0011034) | 3.16650792 |
34 | Prolonged bleeding time (HP:0003010) | 3.08696324 |
35 | Vasculitis (HP:0002633) | 2.99422322 |
36 | Chest pain (HP:0100749) | 2.98681341 |
37 | Pustule (HP:0200039) | 2.98674649 |
38 | Periodontitis (HP:0000704) | 2.94558995 |
39 | Urticaria (HP:0001025) | 2.93597313 |
40 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.89658679 |
41 | Thick nail (HP:0001805) | 2.82184289 |
42 | Abnormality of T cells (HP:0002843) | 2.80060472 |
43 | Pulmonary infiltrates (HP:0002113) | 2.79053601 |
44 | Basal ganglia calcification (HP:0002135) | 2.78941172 |
45 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.78883227 |
46 | Epistaxis (HP:0000421) | 2.77265409 |
47 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.76831157 |
48 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.76831157 |
49 | Abnormality of glycolipid metabolism (HP:0010969) | 2.76831157 |
50 | Agnosia (HP:0010524) | 2.74558386 |
51 | Increased IgE level (HP:0003212) | 2.74224011 |
52 | Mucopolysacchariduria (HP:0008155) | 2.74080267 |
53 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.74080267 |
54 | Episodic fever (HP:0001954) | 2.70443779 |
55 | Inflammation of the large intestine (HP:0002037) | 2.64953517 |
56 | Pulmonary embolism (HP:0002204) | 2.63314843 |
57 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.60208510 |
58 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.60208510 |
59 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.60208510 |
60 | Interstitial pulmonary disease (HP:0006530) | 2.58721120 |
61 | Cellulitis (HP:0100658) | 2.57177900 |
62 | Tetraparesis (HP:0002273) | 2.56459871 |
63 | Premature loss of primary teeth (HP:0006323) | 2.52824149 |
64 | Purpura (HP:0000979) | 2.52348680 |
65 | Gastrointestinal inflammation (HP:0004386) | 2.50476399 |
66 | Osteomyelitis (HP:0002754) | 2.48957024 |
67 | Nephritis (HP:0000123) | 2.48288861 |
68 | Gangrene (HP:0100758) | 2.47831302 |
69 | Panhypogammaglobulinemia (HP:0003139) | 2.47274583 |
70 | Abnormality of the prostate (HP:0008775) | 2.44922386 |
71 | Pathologic fracture (HP:0002756) | 2.44212694 |
72 | Joint hemorrhage (HP:0005261) | 2.43842674 |
73 | Granulocytopenia (HP:0001913) | 2.43590504 |
74 | Meningitis (HP:0001287) | 2.42034571 |
75 | Keratoconjunctivitis sicca (HP:0001097) | 2.36005087 |
76 | Progressive visual loss (HP:0000529) | 2.35527767 |
77 | Recurrent pneumonia (HP:0006532) | 2.34970250 |
78 | Leukocytosis (HP:0001974) | 2.34964700 |
79 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 2.34325543 |
80 | Peritonitis (HP:0002586) | 2.32942214 |
81 | Spontaneous hematomas (HP:0007420) | 2.31694906 |
82 | Hepatosplenomegaly (HP:0001433) | 2.26232715 |
83 | Nausea (HP:0002018) | 2.25437467 |
84 | Bone pain (HP:0002653) | 2.23628301 |
85 | Increased IgM level (HP:0003496) | 2.21367005 |
86 | Polyneuropathy (HP:0001271) | 2.19160876 |
87 | Vertigo (HP:0002321) | 2.18179918 |
88 | Increased serum ferritin (HP:0003281) | 2.15056705 |
89 | Poor head control (HP:0002421) | 2.14351488 |
90 | Osteolytic defects of the hand bones (HP:0009699) | 2.12553163 |
91 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.12553163 |
92 | Petechiae (HP:0000967) | 2.11872307 |
93 | Keratoconjunctivitis (HP:0001096) | 2.11346647 |
94 | Arterial thrombosis (HP:0004420) | 2.10137341 |
95 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.08888411 |
96 | Recurrent cutaneous fungal infections (HP:0011370) | 2.08888411 |
97 | Hypochromic anemia (HP:0001931) | 2.08805322 |
98 | Hypochromic microcytic anemia (HP:0004840) | 2.08714607 |
99 | Glomerulopathy (HP:0100820) | 2.08287853 |
100 | Chronic otitis media (HP:0000389) | 2.07324379 |
101 | Autoimmune hemolytic anemia (HP:0001890) | 2.06940575 |
102 | Abnormality of iron homeostasis (HP:0011031) | 2.06207523 |
103 | Amaurosis fugax (HP:0100576) | 2.05665550 |
104 | Recurrent lower respiratory tract infections (HP:0002783) | 2.05463164 |
105 | Loss of speech (HP:0002371) | 2.05211085 |
106 | Abnormality of T cell physiology (HP:0011840) | 2.05205787 |
107 | Lymphopenia (HP:0001888) | 2.05010842 |
108 | Neoplasm of head and neck (HP:0012288) | 2.02641352 |
109 | Esophageal neoplasm (HP:0100751) | 2.02641352 |
110 | Sepsis (HP:0100806) | 2.01940912 |
111 | Colitis (HP:0002583) | 2.01914061 |
112 | Abnormality of complement system (HP:0005339) | 2.00094497 |
113 | Abnormality of the endocardium (HP:0004306) | 1.99815881 |
114 | Hematochezia (HP:0002573) | 1.99719033 |
115 | Abnormality of eosinophils (HP:0001879) | 1.97294741 |
116 | Eosinophilia (HP:0001880) | 1.94867726 |
117 | Anorexia (HP:0002039) | 1.94295386 |
118 | Myocardial infarction (HP:0001658) | 1.93925656 |
119 | Joint swelling (HP:0001386) | 1.93902257 |
120 | Acne (HP:0001061) | 1.93623788 |
121 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 1.92855369 |
122 | Complement deficiency (HP:0004431) | 1.92848733 |
123 | Slow saccadic eye movements (HP:0000514) | 1.90427865 |
124 | Abnormality of the peritoneum (HP:0002585) | 1.90249046 |
125 | Abnormality of the pleura (HP:0002103) | 1.88952778 |
126 | Keratitis (HP:0000491) | 1.88444112 |
127 | Gingival bleeding (HP:0000225) | 1.87524501 |
128 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.86169572 |
129 | Mutism (HP:0002300) | 1.85485393 |
130 | Encephalitis (HP:0002383) | 1.83949415 |
131 | Metaphyseal cupping (HP:0003021) | 1.83549208 |
132 | Skin ulcer (HP:0200042) | 1.82173300 |
133 | Hemoptysis (HP:0002105) | 1.81905866 |
134 | Upper motor neuron abnormality (HP:0002127) | 1.81070118 |
135 | Vertebral compression fractures (HP:0002953) | 1.76928127 |
136 | Tetany (HP:0001281) | 1.76517836 |
137 | Hypergammaglobulinemia (HP:0010702) | 1.75263054 |
138 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.73300042 |
139 | Abnormality of proline metabolism (HP:0010907) | 1.72264173 |
140 | Hydroxyprolinuria (HP:0003080) | 1.72264173 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TYK2 | 4.43118699 |
2 | BLK | 4.38935375 |
3 | MAP3K14 | 4.27819524 |
4 | IRAK3 | 4.12714425 |
5 | RIPK4 | 3.81721353 |
6 | TBK1 | 3.44847027 |
7 | IRAK4 | 3.33778945 |
8 | IKBKE | 3.07648910 |
9 | PBK | 3.00491607 |
10 | KIT | 2.38353971 |
11 | ERN1 | 2.35440440 |
12 | PRPF4B | 2.23143997 |
13 | JAK1 | 2.20410209 |
14 | IKBKB | 2.15591399 |
15 | TXK | 2.13755756 |
16 | MAP4K1 | 1.90336818 |
17 | TNK2 | 1.89637516 |
18 | CSK | 1.84269601 |
19 | JAK3 | 1.77483311 |
20 | EPHB1 | 1.69237646 |
21 | FGR | 1.59089847 |
22 | PIM2 | 1.58616753 |
23 | TAOK1 | 1.54293485 |
24 | MAP3K13 | 1.47189732 |
25 | TEC | 1.37774110 |
26 | HCK | 1.35009327 |
27 | STK10 | 1.33728697 |
28 | EIF2AK2 | 1.33433063 |
29 | CSF1R | 1.31039427 |
30 | TGFBR2 | 1.30852504 |
31 | LYN | 1.28495620 |
32 | TAOK3 | 1.27205807 |
33 | MAP3K1 | 1.21913246 |
34 | FES | 1.21220701 |
35 | SYK | 1.20660513 |
36 | CHUK | 1.13164359 |
37 | RPS6KA4 | 1.11805323 |
38 | LCK | 1.11610532 |
39 | JAK2 | 1.11499846 |
40 | BTK | 1.10691704 |
41 | ZAP70 | 1.10009021 |
42 | GRK7 | 1.09933002 |
43 | PIM1 | 1.09327955 |
44 | STK4 | 1.05401232 |
45 | MATK | 0.99748415 |
46 | MARK3 | 0.99584503 |
47 | CLK1 | 0.92346240 |
48 | IRAK2 | 0.89671018 |
49 | PDK1 | 0.89532418 |
50 | NEK9 | 0.88330155 |
51 | KSR2 | 0.86575993 |
52 | BMX | 0.85703363 |
53 | PIK3CG | 0.84141148 |
54 | FGFR4 | 0.84028448 |
55 | MARK2 | 0.82599309 |
56 | MAP3K5 | 0.81979371 |
57 | TRPM7 | 0.81584869 |
58 | YES1 | 0.81268264 |
59 | PRKCD | 0.80331128 |
60 | CAMKK2 | 0.79864099 |
61 | PAK4 | 0.77871788 |
62 | EGFR | 0.74544725 |
63 | ABL2 | 0.72992095 |
64 | MAP2K3 | 0.72852577 |
65 | BMPR2 | 0.72469463 |
66 | CDK12 | 0.71839102 |
67 | CDC42BPA | 0.69779741 |
68 | MAPK7 | 0.69467574 |
69 | MAP3K6 | 0.67707934 |
70 | PDPK1 | 0.67498823 |
71 | NME2 | 0.66569702 |
72 | EIF2AK1 | 0.65809820 |
73 | MAP3K2 | 0.62686739 |
74 | PTK6 | 0.62150157 |
75 | ABL1 | 0.61110828 |
76 | CDK19 | 0.61031799 |
77 | SIK2 | 0.60698836 |
78 | CAMK1D | 0.60357979 |
79 | PRKCQ | 0.59369187 |
80 | MAPK12 | 0.59064647 |
81 | MST4 | 0.58232729 |
82 | ARAF | 0.52921494 |
83 | FGFR3 | 0.51069988 |
84 | MAP3K11 | 0.50643668 |
85 | CDK6 | 0.49836465 |
86 | SGK3 | 0.48785075 |
87 | ACVR1B | 0.47973097 |
88 | PTK2B | 0.47868146 |
89 | EPHA3 | 0.46569048 |
90 | PRKD2 | 0.45479747 |
91 | MOS | 0.45461627 |
92 | TTN | 0.45391754 |
93 | LRRK2 | 0.45376133 |
94 | MAP3K7 | 0.43735913 |
95 | MAP2K6 | 0.43449005 |
96 | HIPK2 | 0.42935465 |
97 | PRKG2 | 0.42652816 |
98 | ITK | 0.41053231 |
99 | STK11 | 0.40648303 |
100 | ADRBK2 | 0.40125101 |
101 | CAMKK1 | 0.39076074 |
102 | MAPK11 | 0.38490117 |
103 | SIK3 | 0.38410893 |
104 | NLK | 0.37464585 |
105 | FYN | 0.37431594 |
106 | DYRK1B | 0.37382037 |
107 | SGK2 | 0.36514813 |
108 | MAP2K4 | 0.35518425 |
109 | GRK6 | 0.35277597 |
110 | MST1R | 0.35218430 |
111 | DAPK2 | 0.33750079 |
112 | ALK | 0.33591616 |
113 | ERBB3 | 0.33508883 |
114 | OXSR1 | 0.32801891 |
115 | RAF1 | 0.31712633 |
116 | KSR1 | 0.31649273 |
117 | RET | 0.31567914 |
118 | RPS6KA6 | 0.30178401 |
119 | WNK3 | 0.29174687 |
120 | STK3 | 0.28466998 |
121 | NEK2 | 0.27496679 |
122 | CDK4 | 0.26404707 |
123 | TAOK2 | 0.25360486 |
124 | RPS6KC1 | 0.25104052 |
125 | RPS6KL1 | 0.25104052 |
126 | EIF2AK3 | 0.24832158 |
127 | MAPK4 | 0.24350686 |
128 | IRAK1 | 0.22802536 |
129 | TESK1 | 0.22524319 |
130 | MAPKAPK2 | 0.22476336 |
131 | KDR | 0.20460877 |
132 | ATR | 0.19866575 |
133 | MAP3K3 | 0.19747562 |
134 | IGF1R | 0.19234023 |
135 | TESK2 | 0.17742843 |
136 | INSR | 0.17056557 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 4.06122032 |
2 | Leishmaniasis_Homo sapiens_hsa05140 | 3.53852271 |
3 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.97258009 |
4 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.76071394 |
5 | Legionellosis_Homo sapiens_hsa05134 | 2.63852726 |
6 | Pertussis_Homo sapiens_hsa05133 | 2.60335219 |
7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.59335481 |
8 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.56130957 |
9 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.39415588 |
10 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.35539915 |
11 | Tuberculosis_Homo sapiens_hsa05152 | 2.33780677 |
12 | Lysosome_Homo sapiens_hsa04142 | 2.32763220 |
13 | Allograft rejection_Homo sapiens_hsa05330 | 2.30408623 |
14 | Asthma_Homo sapiens_hsa05310 | 2.26728444 |
15 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.19639350 |
16 | Measles_Homo sapiens_hsa05162 | 2.17918998 |
17 | Malaria_Homo sapiens_hsa05144 | 2.15232946 |
18 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.08086326 |
19 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 2.03719634 |
20 | Other glycan degradation_Homo sapiens_hsa00511 | 1.99648987 |
21 | Influenza A_Homo sapiens_hsa05164 | 1.95260086 |
22 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.91040411 |
23 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.77876911 |
24 | Phagosome_Homo sapiens_hsa04145 | 1.77443425 |
25 | Salmonella infection_Homo sapiens_hsa05132 | 1.68593947 |
26 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.68487230 |
27 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.66378931 |
28 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.61374958 |
29 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.48301794 |
30 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.47103171 |
31 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.45307722 |
32 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.40966791 |
33 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.40506352 |
34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.36586830 |
35 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.36523329 |
36 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.36262377 |
37 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.28557866 |
38 | Apoptosis_Homo sapiens_hsa04210 | 1.28441788 |
39 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.24730218 |
40 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.20150141 |
41 | Hepatitis C_Homo sapiens_hsa05160 | 1.18631426 |
42 | Shigellosis_Homo sapiens_hsa05131 | 1.12302961 |
43 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.09341939 |
44 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.02240557 |
45 | Hepatitis B_Homo sapiens_hsa05161 | 1.00309400 |
46 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.92218606 |
47 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.91228823 |
48 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.87922782 |
49 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.85382614 |
50 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.84267285 |
51 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.84116049 |
52 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.84023720 |
53 | Mineral absorption_Homo sapiens_hsa04978 | 0.81344603 |
54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.78305160 |
55 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.78263996 |
56 | Amoebiasis_Homo sapiens_hsa05146 | 0.76785098 |
57 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.76087601 |
58 | Viral myocarditis_Homo sapiens_hsa05416 | 0.75815622 |
59 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.74692716 |
60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.73119960 |
61 | Prion diseases_Homo sapiens_hsa05020 | 0.67142818 |
62 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.66293701 |
63 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.60893809 |
64 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.60300200 |
65 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.60088080 |
66 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.59144862 |
67 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.57890573 |
68 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55845925 |
69 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.54443985 |
70 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.53840479 |
71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.53557541 |
72 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.52943842 |
73 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.51615332 |
74 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.50848994 |
75 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.50082938 |
76 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.49207894 |
77 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.48497185 |
78 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.47916262 |
79 | HTLV-I infection_Homo sapiens_hsa05166 | 0.46711735 |
80 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.46670272 |
81 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.46067706 |
82 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.45741494 |
83 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.45223257 |
84 | Peroxisome_Homo sapiens_hsa04146 | 0.41829103 |
85 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.39761133 |
86 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.38951947 |
87 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.38619144 |
88 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.36802339 |
89 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.35642179 |
90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.35094112 |
91 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34748233 |
92 | Endometrial cancer_Homo sapiens_hsa05213 | 0.33848500 |
93 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.33684549 |
94 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.31521568 |
95 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.31039696 |
96 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.28846990 |
97 | Platelet activation_Homo sapiens_hsa04611 | 0.28032776 |
98 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.27332085 |
99 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.26771368 |
100 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.26515988 |
101 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.25953095 |
102 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.25820197 |
103 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.25538331 |
104 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.25121384 |
105 | Colorectal cancer_Homo sapiens_hsa05210 | 0.24887782 |
106 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.24165456 |
107 | Histidine metabolism_Homo sapiens_hsa00340 | 0.23651324 |
108 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.23026508 |
109 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.22782176 |
110 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.22651051 |
111 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.21587544 |
112 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21081231 |
113 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.20882997 |
114 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.19434361 |
115 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.18902694 |
116 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.18703252 |
117 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.18584350 |
118 | Galactose metabolism_Homo sapiens_hsa00052 | 0.18074669 |
119 | Endocytosis_Homo sapiens_hsa04144 | 0.17517676 |
120 | Insulin resistance_Homo sapiens_hsa04931 | 0.16915590 |
121 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.15833286 |
122 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.15811128 |