AOAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.92339592
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.92339592
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.92339592
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.92339592
5modulation by symbiont of host immune response (GO:0052553)6.92339592
6positive regulation by symbiont of host defense response (GO:0052509)6.92339592
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.03055695
8negative regulation of cell killing (GO:0031342)6.03055695
9response to peptidoglycan (GO:0032494)5.87633968
10neutrophil activation involved in immune response (GO:0002283)5.64123125
11positive regulation of interferon-alpha production (GO:0032727)5.50844407
12regulation of interferon-alpha production (GO:0032647)5.30907985
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.11791542
14regulation of interferon-beta biosynthetic process (GO:0045357)4.90564051
15immunoglobulin mediated immune response (GO:0016064)4.89467212
16macrophage activation involved in immune response (GO:0002281)4.87132546
17positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.85073645
18response to host immune response (GO:0052572)4.76262492
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.76262492
20respiratory burst (GO:0045730)4.72519664
21antigen processing and presentation of endogenous antigen (GO:0019883)4.61112954
22regulation of gamma-delta T cell activation (GO:0046643)4.58080421
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47454909
24detection of bacterium (GO:0016045)4.44253580
25hydrogen peroxide biosynthetic process (GO:0050665)4.31225924
26microglial cell activation (GO:0001774)4.20147724
27response to host (GO:0075136)4.19918217
28response to host defenses (GO:0052200)4.19918217
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.19918217
30detection of external biotic stimulus (GO:0098581)4.17508995
31superoxide anion generation (GO:0042554)4.15951990
32granulocyte activation (GO:0036230)4.13626675
33eosinophil chemotaxis (GO:0048245)4.07075444
34positive regulation of chemokine biosynthetic process (GO:0045080)4.07041825
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06700216
36lipopolysaccharide-mediated signaling pathway (GO:0031663)4.06687176
37neutrophil activation (GO:0042119)4.05383001
38reactive oxygen species biosynthetic process (GO:1903409)4.04704884
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01928223
40regulation of gamma-delta T cell differentiation (GO:0045586)3.97983934
41positive regulation of interferon-beta production (GO:0032728)3.95884833
42cellular response to type I interferon (GO:0071357)3.93628177
43type I interferon signaling pathway (GO:0060337)3.93628177
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.89251418
45response to type I interferon (GO:0034340)3.89189147
46positive regulation of cellular amide metabolic process (GO:0034250)3.88497345
47response to muramyl dipeptide (GO:0032495)3.85170304
48detection of biotic stimulus (GO:0009595)3.80252662
49B cell mediated immunity (GO:0019724)3.78706543
50negative regulation of T cell mediated immunity (GO:0002710)3.78504118
51macrophage activation (GO:0042116)3.73904399
52eosinophil migration (GO:0072677)3.69825086
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.62506405
54natural killer cell mediated immunity (GO:0002228)3.60774935
55natural killer cell mediated cytotoxicity (GO:0042267)3.60774935
56positive regulation of heat generation (GO:0031652)3.59133293
57myeloid cell activation involved in immune response (GO:0002275)3.57655590
58production of molecular mediator involved in inflammatory response (GO:0002532)3.56472523
59response to interferon-alpha (GO:0035455)3.54885695
60negative regulation of leukocyte mediated immunity (GO:0002704)3.53426952
61positive regulation of antigen processing and presentation (GO:0002579)3.50887980
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.46441317
63regulation of chemokine biosynthetic process (GO:0045073)3.46311343
64regulation of interleukin-8 biosynthetic process (GO:0045414)3.42947302
65regulation of mononuclear cell migration (GO:0071675)3.42839219
66neutrophil mediated immunity (GO:0002446)3.40269755
67cellular extravasation (GO:0045123)3.39833903
68negative regulation of interleukin-12 production (GO:0032695)3.36797205
69detection of molecule of bacterial origin (GO:0032490)3.33824237
70lymphocyte chemotaxis (GO:0048247)3.33100538
71interferon-gamma-mediated signaling pathway (GO:0060333)3.32547558
72positive thymic T cell selection (GO:0045059)3.32317399
73leukocyte mediated cytotoxicity (GO:0001909)3.31538643
74positive regulation of B cell differentiation (GO:0045579)3.31422078
75positive regulation of mast cell activation (GO:0033005)3.28999434
76regulation of tolerance induction (GO:0002643)3.28872838
77regulation of fever generation (GO:0031620)3.28238503
78response to interleukin-15 (GO:0070672)3.27537567
79regulation of T cell tolerance induction (GO:0002664)3.26148653
80negative T cell selection (GO:0043383)3.25966035
81negative thymic T cell selection (GO:0045060)3.25594644
82antigen processing and presentation via MHC class Ib (GO:0002475)3.24173192
83negative regulation of erythrocyte differentiation (GO:0045647)3.24073092
84activated T cell proliferation (GO:0050798)3.24054725
85negative regulation of viral genome replication (GO:0045071)3.22615893
86positive regulation of toll-like receptor signaling pathway (GO:0034123)3.22571241
87positive regulation of mast cell activation involved in immune response (GO:0033008)3.22285370
88positive regulation of mast cell degranulation (GO:0043306)3.22285370
89leukocyte aggregation (GO:0070486)3.22220177
90regulation of mast cell degranulation (GO:0043304)3.22139989
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.20379376
92T cell migration (GO:0072678)3.19575463
93B cell receptor signaling pathway (GO:0050853)3.17572677
94monocyte chemotaxis (GO:0002548)3.15738968
95regulation of B cell differentiation (GO:0045577)3.14573509
96myeloid leukocyte mediated immunity (GO:0002444)3.13315527
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.12022991
98I-kappaB phosphorylation (GO:0007252)3.10582882
99positive regulation of gamma-delta T cell activation (GO:0046645)3.09787346
100positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.07314145
101positive regulation of interleukin-1 beta secretion (GO:0050718)3.06293626
102regulation of B cell receptor signaling pathway (GO:0050855)3.06040924
103leukocyte migration involved in inflammatory response (GO:0002523)3.05535524
104positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05106389
105leukocyte degranulation (GO:0043299)3.04295745
106negative regulation of myeloid cell apoptotic process (GO:0033033)3.03663375
107regulation of mast cell activation involved in immune response (GO:0033006)3.03588735
108positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.03518998
109germinal center formation (GO:0002467)3.03044926
110cellular response to interleukin-15 (GO:0071350)3.02166728
111response to protozoan (GO:0001562)3.02041660
112defense response to protozoan (GO:0042832)3.01298312
113regulation of antigen processing and presentation (GO:0002577)3.00197870
114cellular response to virus (GO:0098586)3.00060045
115NIK/NF-kappaB signaling (GO:0038061)2.98469597
116regulation of natural killer cell mediated immunity (GO:0002715)2.97520255
117regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.97520255
118regulation of mast cell activation (GO:0033003)2.96169450
119positive T cell selection (GO:0043368)2.96150398
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95594290
121positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.94968670
122pinocytosis (GO:0006907)2.94004312
123regulation of leukocyte degranulation (GO:0043300)2.92868436
124T cell selection (GO:0045058)2.92591268
125interferon-gamma production (GO:0032609)2.91737499
126regulation of alpha-beta T cell proliferation (GO:0046640)2.91004390
127lymphocyte mediated immunity (GO:0002449)2.90778352
128cellular response to interferon-beta (GO:0035458)2.90459743
129positive regulation of lymphocyte migration (GO:2000403)2.89253350
130regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89249073
131positive regulation of monocyte chemotaxis (GO:0090026)2.88507752
132T-helper 1 type immune response (GO:0042088)2.86986209
133regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86323234
134response to interferon-beta (GO:0035456)2.85576732
135positive regulation of leukocyte degranulation (GO:0043302)2.84909364
136regulation of interferon-beta production (GO:0032648)2.84229547
137detection of other organism (GO:0098543)2.83196255
138basic amino acid transport (GO:0015802)2.82542465
139myeloid leukocyte activation (GO:0002274)2.82335727
140positive regulation of interleukin-1 secretion (GO:0050716)2.81961049
141neutrophil migration (GO:1990266)2.81501523
142neutrophil chemotaxis (GO:0030593)2.80312002
143cellular response to interferon-gamma (GO:0071346)2.78641963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.60128810
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.63636757
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.01999219
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.72595772
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.34315764
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30209414
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20664694
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.89512631
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.60776273
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.29012636
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.13975105
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.99755910
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85073503
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69702805
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60367665
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53752608
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52411201
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.48373808
19* SPI1_23547873_ChIP-Seq_NB4_Human2.37637020
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.31246717
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25375126
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.98836574
23E2F7_22180533_ChIP-Seq_HELA_Human1.96396602
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91169477
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87815668
26* PU_27001747_Chip-Seq_BMDM_Mouse1.79710138
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.73594674
28CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72781060
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71825005
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71813567
31CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67615789
32SCL_19346495_ChIP-Seq_HPC-7_Human1.63417647
33SPI1_23127762_ChIP-Seq_K562_Human1.62846379
34VDR_24763502_ChIP-Seq_THP-1_Human1.61842833
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53214237
36* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50952780
37MYB_26560356_Chip-Seq_TH2_Human1.50114943
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49697164
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45471083
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44101844
41CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43598993
42VDR_24787735_ChIP-Seq_THP-1_Human1.43141975
43VDR_21846776_ChIP-Seq_THP-1_Human1.42785074
44* MAF_26560356_Chip-Seq_TH1_Human1.39959978
45MYB_26560356_Chip-Seq_TH1_Human1.36806227
46KDM2B_26808549_Chip-Seq_DND41_Human1.35609120
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33397135
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32123974
49GATA1_22025678_ChIP-Seq_K562_Human1.29911391
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27349173
51SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25246918
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24503064
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24272172
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20996471
55GATA3_26560356_Chip-Seq_TH2_Human1.20350509
56GATA1_19941826_ChIP-Seq_K562_Human1.17834648
57* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16638562
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15088417
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13764742
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12988244
61RUNX_20019798_ChIP-Seq_JUKART_Human1.12610736
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12119463
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11879687
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09745410
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06109694
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03929216
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.03886446
68TFEB_21752829_ChIP-Seq_HELA_Human1.03548911
69UTX_26944678_Chip-Seq_JUKART_Human1.03050937
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02947783
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02303553
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01976046
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01697179
74EGR1_19032775_ChIP-ChIP_M12_Human0.99374752
75IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99079139
76GATA2_19941826_ChIP-Seq_K562_Human0.97873789
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96712602
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93679039
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92752515
80GATA3_27048872_Chip-Seq_THYMUS_Human0.90891058
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89375635
82KDM2B_26808549_Chip-Seq_JURKAT_Human0.86998963
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86593497
84BCL6_27268052_Chip-Seq_Bcells_Human0.85806568
85SPI1_20517297_ChIP-Seq_HL60_Human0.82808273
86* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81098166
87GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80825291
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80662683
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80185462
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80041472
91SMRT_27268052_Chip-Seq_Bcells_Human0.78953296
92BCOR_27268052_Chip-Seq_Bcells_Human0.78037216
93LXR_22292898_ChIP-Seq_THP-1_Human0.77615352
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76807943
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75693173
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74127032
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71662448
98FOXM1_23109430_ChIP-Seq_U2OS_Human0.71639042
99NCOR1_26117541_ChIP-Seq_K562_Human0.71315242
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71027950
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.69240262
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69195462
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.68868978
104MAF_26560356_Chip-Seq_TH2_Human0.68229191
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67443550
106TCF7_22412390_ChIP-Seq_EML_Mouse0.65965838
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.63712450
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.62255120
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.59214731
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.57112062
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.56967617
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56260850
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56027425
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.55767453
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.55545323
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.55308404
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.55021290
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.55021290
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.55021290
120MYC_22102868_ChIP-Seq_BL_Human0.54646685
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54002792
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.53984042
123TP63_17297297_ChIP-ChIP_HaCaT_Human0.53380463

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.18089554
2MP0005058_abnormal_lysosome_morphology3.80783793
3MP0009785_altered_susceptibility_to3.76370495
4MP0003436_decreased_susceptibility_to3.67506499
5MP0003303_peritoneal_inflammation3.42099916
6MP0002419_abnormal_innate_immunity3.27386805
7MP0002148_abnormal_hypersensitivity_rea3.19725662
8MP0006082_CNS_inflammation3.09832976
9MP0005000_abnormal_immune_tolerance2.95938577
10MP0005025_abnormal_response_to2.94990390
11MP0003724_increased_susceptibility_to2.91669075
12MP0001790_abnormal_immune_system2.71880218
13MP0005387_immune_system_phenotype2.71880218
14MP0005671_abnormal_response_to2.57210189
15MP0002452_abnormal_antigen_presenting2.50425237
16MP0003172_abnormal_lysosome_physiology2.47978438
17* MP0001800_abnormal_humoral_immune2.36676933
18MP0002723_abnormal_immune_serum2.34637633
19MP0009840_abnormal_foam_cell2.33741168
20MP0000685_abnormal_immune_system2.23804443
21MP0001533_abnormal_skeleton_physiology2.11712258
22MP0000343_altered_response_to2.09826137
23MP0003763_abnormal_thymus_physiology2.08631292
24MP0001819_abnormal_immune_cell2.07418179
25MP0004510_myositis2.06808144
26MP0002420_abnormal_adaptive_immunity2.04581823
27MP0005464_abnormal_platelet_physiology2.01479997
28MP0009764_decreased_sensitivity_to2.00201836
29MP0004947_skin_inflammation1.91860861
30MP0001845_abnormal_inflammatory_respons1.90905560
31MP0002405_respiratory_system_inflammati1.89946555
32MP0003075_altered_response_to1.87468992
33MP0009278_abnormal_bone_marrow1.84168188
34MP0000569_abnormal_digit_pigmentation1.83077945
35MP0008469_abnormal_protein_level1.82033971
36MP0003448_altered_tumor_morphology1.81996882
37MP0001853_heart_inflammation1.75858988
38MP0000604_amyloidosis1.75498192
39MP0003186_abnormal_redox_activity1.63567396
40MP0005310_abnormal_salivary_gland1.57474028
41MP0010155_abnormal_intestine_physiology1.57469360
42MP0005451_abnormal_body_composition1.50052616
43MP0000465_gastrointestinal_hemorrhage1.50047478
44MP0002998_abnormal_bone_remodeling1.48221887
45MP0000716_abnormal_immune_system1.46662523
46MP0003690_abnormal_glial_cell1.46325219
47MP0000858_altered_metastatic_potential1.45675577
48MP0003866_abnormal_defecation1.43905943
49MP0005167_abnormal_blood-brain_barrier1.43391077
50MP0010307_abnormal_tumor_latency1.39718509
51MP0002277_abnormal_respiratory_mucosa1.38226069
52MP0002398_abnormal_bone_marrow1.33192378
53MP0002132_abnormal_respiratory_system1.33094770
54MP0002006_tumorigenesis1.32411269
55MP0000689_abnormal_spleen_morphology1.29686087
56MP0005166_decreased_susceptibility_to1.26939982
57MP0009333_abnormal_splenocyte_physiolog1.25173948
58MP0000703_abnormal_thymus_morphology1.25119816
59MP0001545_abnormal_hematopoietic_system1.23542069
60MP0005397_hematopoietic_system_phenotyp1.23542069
61MP0003191_abnormal_cellular_cholesterol1.23019147
62MP0002429_abnormal_blood_cell1.21586270
63MP0003183_abnormal_peptide_metabolism1.20145236
64MP0003300_gastrointestinal_ulcer1.18535396
65MP0003195_calcinosis1.18497327
66MP0005164_abnormal_response_to1.17637975
67MP0002722_abnormal_immune_system1.14346794
68MP0004381_abnormal_hair_follicle1.11528182
69MP0009763_increased_sensitivity_to1.08112188
70MP0002136_abnormal_kidney_physiology1.04750601
71MP0004782_abnormal_surfactant_physiolog1.02757121
72MP0002138_abnormal_hepatobiliary_system1.01249888
73MP0003566_abnormal_cell_adhesion1.00266386
74MP0005174_abnormal_tail_pigmentation0.97881835
75MP0008260_abnormal_autophagy0.95551381
76MP0002166_altered_tumor_susceptibility0.95132526
77MP0004858_abnormal_nervous_system0.93767112
78MP0003828_pulmonary_edema0.93164392
79MP0010352_gastrointestinal_tract_polyps0.91323155
80MP0002254_reproductive_system_inflammat0.91102486
81MP0005390_skeleton_phenotype0.90423482
82MP0003806_abnormal_nucleotide_metabolis0.87714935
83MP0005076_abnormal_cell_differentiation0.87127876
84MP0000371_diluted_coat_color0.86776890
85MP0001663_abnormal_digestive_system0.84083884
86MP0002332_abnormal_exercise_endurance0.83857487
87MP0005075_abnormal_melanosome_morpholog0.82092826
88MP0000015_abnormal_ear_pigmentation0.79937712
89MP0009643_abnormal_urine_homeostasis0.79524269
90MP0004019_abnormal_vitamin_homeostasis0.79382158
91MP0001873_stomach_inflammation0.78263745
92MP0005319_abnormal_enzyme/_coenzyme0.77346776
93MP0005023_abnormal_wound_healing0.76149151
94MP0003795_abnormal_bone_structure0.74840843
95MP0001851_eye_inflammation0.73152056
96MP0002933_joint_inflammation0.73037598
97MP0009765_abnormal_xenobiotic_induced0.72635975
98MP0004883_abnormal_blood_vessel0.71789524
99MP0008004_abnormal_stomach_pH0.71334062
100MP0003656_abnormal_erythrocyte_physiolo0.71086604
101MP0000249_abnormal_blood_vessel0.71044662
102MP0001986_abnormal_taste_sensitivity0.70466191
103MP0002396_abnormal_hematopoietic_system0.68398493
104MP0003045_fibrosis0.67459627
105MP0003453_abnormal_keratinocyte_physiol0.65160246
106MP0001958_emphysema0.65154210
107MP0002009_preneoplasia0.63512562
108MP0000920_abnormal_myelination0.62319664
109MP0008874_decreased_physiological_sensi0.60936365
110MP0005584_abnormal_enzyme/coenzyme_acti0.59590757
111MP0000609_abnormal_liver_physiology0.59066348
112MP0006054_spinal_hemorrhage0.58574824
113MP0000490_abnormal_crypts_of0.56881441
114MP0005083_abnormal_biliary_tract0.56768660
115MP0004808_abnormal_hematopoietic_stem0.56764345
116MP0008873_increased_physiological_sensi0.56697533
117MP0005332_abnormal_amino_acid0.55487757
118MP0003329_amyloid_beta_deposits0.54061347
119MP0004130_abnormal_muscle_cell0.53993582
120MP0003091_abnormal_cell_migration0.53780338
121MP0003221_abnormal_cardiomyocyte_apopto0.52582899

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.69178423
2Recurrent bacterial skin infections (HP:0005406)6.93712135
3Eczematoid dermatitis (HP:0000976)6.82255141
4Recurrent gram-negative bacterial infections (HP:0005420)5.74527239
5Systemic lupus erythematosus (HP:0002725)5.57799372
6Abnormality of macrophages (HP:0004311)5.50959103
7Mediastinal lymphadenopathy (HP:0100721)4.90178553
8Vacuolated lymphocytes (HP:0001922)4.77997736
9Stomatitis (HP:0010280)4.49384146
10Autoimmune thrombocytopenia (HP:0001973)4.44411147
11Increased cerebral lipofuscin (HP:0011813)4.27587397
12Orchitis (HP:0100796)4.13589631
13Gingivitis (HP:0000230)4.08126151
14Myositis (HP:0100614)3.95941621
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.95209335
16Recurrent skin infections (HP:0001581)3.92310831
17Prostate neoplasm (HP:0100787)3.87338724
18Elevated erythrocyte sedimentation rate (HP:0003565)3.87256048
19T lymphocytopenia (HP:0005403)3.83568190
20Retrobulbar optic neuritis (HP:0100654)3.81844445
21Optic neuritis (HP:0100653)3.81844445
22Gastrointestinal infarctions (HP:0005244)3.81045514
23Obstructive lung disease (HP:0006536)3.75261244
24Chronic obstructive pulmonary disease (HP:0006510)3.75261244
25Glomerulonephritis (HP:0000099)3.61611355
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.61507624
27Abnormality of T cell number (HP:0011839)3.61260643
28Axonal loss (HP:0003447)3.48954876
29Recurrent fungal infections (HP:0002841)3.44488800
30Recurrent viral infections (HP:0004429)3.33314065
31Disinhibition (HP:0000734)3.30651292
32Dysostosis multiplex (HP:0000943)3.17021892
33Amyloidosis (HP:0011034)3.16650792
34Prolonged bleeding time (HP:0003010)3.08696324
35Vasculitis (HP:0002633)2.99422322
36Chest pain (HP:0100749)2.98681341
37Pustule (HP:0200039)2.98674649
38Periodontitis (HP:0000704)2.94558995
39Urticaria (HP:0001025)2.93597313
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.89658679
41Thick nail (HP:0001805)2.82184289
42Abnormality of T cells (HP:0002843)2.80060472
43Pulmonary infiltrates (HP:0002113)2.79053601
44Basal ganglia calcification (HP:0002135)2.78941172
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78883227
46Epistaxis (HP:0000421)2.77265409
47Abnormality of liposaccharide metabolism (HP:0010968)2.76831157
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.76831157
49Abnormality of glycolipid metabolism (HP:0010969)2.76831157
50Agnosia (HP:0010524)2.74558386
51Increased IgE level (HP:0003212)2.74224011
52Mucopolysacchariduria (HP:0008155)2.74080267
53Urinary glycosaminoglycan excretion (HP:0003541)2.74080267
54Episodic fever (HP:0001954)2.70443779
55Inflammation of the large intestine (HP:0002037)2.64953517
56Pulmonary embolism (HP:0002204)2.63314843
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.60208510
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.60208510
59Abnormality of polysaccharide metabolism (HP:0011012)2.60208510
60Interstitial pulmonary disease (HP:0006530)2.58721120
61Cellulitis (HP:0100658)2.57177900
62Tetraparesis (HP:0002273)2.56459871
63Premature loss of primary teeth (HP:0006323)2.52824149
64Purpura (HP:0000979)2.52348680
65Gastrointestinal inflammation (HP:0004386)2.50476399
66Osteomyelitis (HP:0002754)2.48957024
67Nephritis (HP:0000123)2.48288861
68Gangrene (HP:0100758)2.47831302
69Panhypogammaglobulinemia (HP:0003139)2.47274583
70Abnormality of the prostate (HP:0008775)2.44922386
71Pathologic fracture (HP:0002756)2.44212694
72Joint hemorrhage (HP:0005261)2.43842674
73Granulocytopenia (HP:0001913)2.43590504
74Meningitis (HP:0001287)2.42034571
75Keratoconjunctivitis sicca (HP:0001097)2.36005087
76Progressive visual loss (HP:0000529)2.35527767
77Recurrent pneumonia (HP:0006532)2.34970250
78Leukocytosis (HP:0001974)2.34964700
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.34325543
80Peritonitis (HP:0002586)2.32942214
81Spontaneous hematomas (HP:0007420)2.31694906
82Hepatosplenomegaly (HP:0001433)2.26232715
83Nausea (HP:0002018)2.25437467
84Bone pain (HP:0002653)2.23628301
85Increased IgM level (HP:0003496)2.21367005
86Polyneuropathy (HP:0001271)2.19160876
87Vertigo (HP:0002321)2.18179918
88Increased serum ferritin (HP:0003281)2.15056705
89Poor head control (HP:0002421)2.14351488
90Osteolytic defects of the hand bones (HP:0009699)2.12553163
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.12553163
92Petechiae (HP:0000967)2.11872307
93Keratoconjunctivitis (HP:0001096)2.11346647
94Arterial thrombosis (HP:0004420)2.10137341
95Chronic mucocutaneous candidiasis (HP:0002728)2.08888411
96Recurrent cutaneous fungal infections (HP:0011370)2.08888411
97Hypochromic anemia (HP:0001931)2.08805322
98Hypochromic microcytic anemia (HP:0004840)2.08714607
99Glomerulopathy (HP:0100820)2.08287853
100Chronic otitis media (HP:0000389)2.07324379
101Autoimmune hemolytic anemia (HP:0001890)2.06940575
102Abnormality of iron homeostasis (HP:0011031)2.06207523
103Amaurosis fugax (HP:0100576)2.05665550
104Recurrent lower respiratory tract infections (HP:0002783)2.05463164
105Loss of speech (HP:0002371)2.05211085
106Abnormality of T cell physiology (HP:0011840)2.05205787
107Lymphopenia (HP:0001888)2.05010842
108Neoplasm of head and neck (HP:0012288)2.02641352
109Esophageal neoplasm (HP:0100751)2.02641352
110Sepsis (HP:0100806)2.01940912
111Colitis (HP:0002583)2.01914061
112Abnormality of complement system (HP:0005339)2.00094497
113Abnormality of the endocardium (HP:0004306)1.99815881
114Hematochezia (HP:0002573)1.99719033
115Abnormality of eosinophils (HP:0001879)1.97294741
116Eosinophilia (HP:0001880)1.94867726
117Anorexia (HP:0002039)1.94295386
118Myocardial infarction (HP:0001658)1.93925656
119Joint swelling (HP:0001386)1.93902257
120Acne (HP:0001061)1.93623788
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.92855369
122Complement deficiency (HP:0004431)1.92848733
123Slow saccadic eye movements (HP:0000514)1.90427865
124Abnormality of the peritoneum (HP:0002585)1.90249046
125Abnormality of the pleura (HP:0002103)1.88952778
126Keratitis (HP:0000491)1.88444112
127Gingival bleeding (HP:0000225)1.87524501
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86169572
129Mutism (HP:0002300)1.85485393
130Encephalitis (HP:0002383)1.83949415
131Metaphyseal cupping (HP:0003021)1.83549208
132Skin ulcer (HP:0200042)1.82173300
133Hemoptysis (HP:0002105)1.81905866
134Upper motor neuron abnormality (HP:0002127)1.81070118
135Vertebral compression fractures (HP:0002953)1.76928127
136Tetany (HP:0001281)1.76517836
137Hypergammaglobulinemia (HP:0010702)1.75263054
138Abnormality of transition element cation homeostasis (HP:0011030)1.73300042
139Abnormality of proline metabolism (HP:0010907)1.72264173
140Hydroxyprolinuria (HP:0003080)1.72264173

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.43118699
2BLK4.38935375
3MAP3K144.27819524
4IRAK34.12714425
5RIPK43.81721353
6TBK13.44847027
7IRAK43.33778945
8IKBKE3.07648910
9PBK3.00491607
10KIT2.38353971
11ERN12.35440440
12PRPF4B2.23143997
13JAK12.20410209
14IKBKB2.15591399
15TXK2.13755756
16MAP4K11.90336818
17TNK21.89637516
18CSK1.84269601
19JAK31.77483311
20EPHB11.69237646
21FGR1.59089847
22PIM21.58616753
23TAOK11.54293485
24MAP3K131.47189732
25TEC1.37774110
26HCK1.35009327
27STK101.33728697
28EIF2AK21.33433063
29CSF1R1.31039427
30TGFBR21.30852504
31LYN1.28495620
32TAOK31.27205807
33MAP3K11.21913246
34FES1.21220701
35SYK1.20660513
36CHUK1.13164359
37RPS6KA41.11805323
38LCK1.11610532
39JAK21.11499846
40BTK1.10691704
41ZAP701.10009021
42GRK71.09933002
43PIM11.09327955
44STK41.05401232
45MATK0.99748415
46MARK30.99584503
47CLK10.92346240
48IRAK20.89671018
49PDK10.89532418
50NEK90.88330155
51KSR20.86575993
52BMX0.85703363
53PIK3CG0.84141148
54FGFR40.84028448
55MARK20.82599309
56MAP3K50.81979371
57TRPM70.81584869
58YES10.81268264
59PRKCD0.80331128
60CAMKK20.79864099
61PAK40.77871788
62EGFR0.74544725
63ABL20.72992095
64MAP2K30.72852577
65BMPR20.72469463
66CDK120.71839102
67CDC42BPA0.69779741
68MAPK70.69467574
69MAP3K60.67707934
70PDPK10.67498823
71NME20.66569702
72EIF2AK10.65809820
73MAP3K20.62686739
74PTK60.62150157
75ABL10.61110828
76CDK190.61031799
77SIK20.60698836
78CAMK1D0.60357979
79PRKCQ0.59369187
80MAPK120.59064647
81MST40.58232729
82ARAF0.52921494
83FGFR30.51069988
84MAP3K110.50643668
85CDK60.49836465
86SGK30.48785075
87ACVR1B0.47973097
88PTK2B0.47868146
89EPHA30.46569048
90PRKD20.45479747
91MOS0.45461627
92TTN0.45391754
93LRRK20.45376133
94MAP3K70.43735913
95MAP2K60.43449005
96HIPK20.42935465
97PRKG20.42652816
98ITK0.41053231
99STK110.40648303
100ADRBK20.40125101
101CAMKK10.39076074
102MAPK110.38490117
103SIK30.38410893
104NLK0.37464585
105FYN0.37431594
106DYRK1B0.37382037
107SGK20.36514813
108MAP2K40.35518425
109GRK60.35277597
110MST1R0.35218430
111DAPK20.33750079
112ALK0.33591616
113ERBB30.33508883
114OXSR10.32801891
115RAF10.31712633
116KSR10.31649273
117RET0.31567914
118RPS6KA60.30178401
119WNK30.29174687
120STK30.28466998
121NEK20.27496679
122CDK40.26404707
123TAOK20.25360486
124RPS6KC10.25104052
125RPS6KL10.25104052
126EIF2AK30.24832158
127MAPK40.24350686
128IRAK10.22802536
129TESK10.22524319
130MAPKAPK20.22476336
131KDR0.20460877
132ATR0.19866575
133MAP3K30.19747562
134IGF1R0.19234023
135TESK20.17742843
136INSR0.17056557

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.06122032
2Leishmaniasis_Homo sapiens_hsa051403.53852271
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.97258009
4Graft-versus-host disease_Homo sapiens_hsa053322.76071394
5Legionellosis_Homo sapiens_hsa051342.63852726
6Pertussis_Homo sapiens_hsa051332.60335219
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.59335481
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56130957
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.39415588
10Osteoclast differentiation_Homo sapiens_hsa043802.35539915
11Tuberculosis_Homo sapiens_hsa051522.33780677
12Lysosome_Homo sapiens_hsa041422.32763220
13Allograft rejection_Homo sapiens_hsa053302.30408623
14Asthma_Homo sapiens_hsa053102.26728444
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19639350
16Measles_Homo sapiens_hsa051622.17918998
17Malaria_Homo sapiens_hsa051442.15232946
18Rheumatoid arthritis_Homo sapiens_hsa053232.08086326
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.03719634
20Other glycan degradation_Homo sapiens_hsa005111.99648987
21Influenza A_Homo sapiens_hsa051641.95260086
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91040411
23TNF signaling pathway_Homo sapiens_hsa046681.77876911
24Phagosome_Homo sapiens_hsa041451.77443425
25Salmonella infection_Homo sapiens_hsa051321.68593947
26Herpes simplex infection_Homo sapiens_hsa051681.68487230
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.66378931
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61374958
29Hematopoietic cell lineage_Homo sapiens_hsa046401.48301794
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47103171
31B cell receptor signaling pathway_Homo sapiens_hsa046621.45307722
32Toxoplasmosis_Homo sapiens_hsa051451.40966791
33African trypanosomiasis_Homo sapiens_hsa051431.40506352
34Antigen processing and presentation_Homo sapiens_hsa046121.36586830
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36523329
36Type I diabetes mellitus_Homo sapiens_hsa049401.36262377
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28557866
38Apoptosis_Homo sapiens_hsa042101.28441788
39Chemokine signaling pathway_Homo sapiens_hsa040621.24730218
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20150141
41Hepatitis C_Homo sapiens_hsa051601.18631426
42Shigellosis_Homo sapiens_hsa051311.12302961
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.09341939
44Autoimmune thyroid disease_Homo sapiens_hsa053201.02240557
45Hepatitis B_Homo sapiens_hsa051611.00309400
46Complement and coagulation cascades_Homo sapiens_hsa046100.92218606
47Non-small cell lung cancer_Homo sapiens_hsa052230.91228823
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87922782
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85382614
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84267285
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84116049
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.84023720
53Mineral absorption_Homo sapiens_hsa049780.81344603
54Collecting duct acid secretion_Homo sapiens_hsa049660.78305160
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78263996
56Amoebiasis_Homo sapiens_hsa051460.76785098
57Primary immunodeficiency_Homo sapiens_hsa053400.76087601
58Viral myocarditis_Homo sapiens_hsa054160.75815622
59VEGF signaling pathway_Homo sapiens_hsa043700.74692716
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73119960
61Prion diseases_Homo sapiens_hsa050200.67142818
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66293701
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60893809
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60300200
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60088080
66Renal cell carcinoma_Homo sapiens_hsa052110.59144862
67Dorso-ventral axis formation_Homo sapiens_hsa043200.57890573
68Caffeine metabolism_Homo sapiens_hsa002320.55845925
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54443985
70FoxO signaling pathway_Homo sapiens_hsa040680.53840479
71Epstein-Barr virus infection_Homo sapiens_hsa051690.53557541
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.52943842
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51615332
74Folate biosynthesis_Homo sapiens_hsa007900.50848994
75GnRH signaling pathway_Homo sapiens_hsa049120.50082938
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49207894
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.48497185
78HIF-1 signaling pathway_Homo sapiens_hsa040660.47916262
79HTLV-I infection_Homo sapiens_hsa051660.46711735
80T cell receptor signaling pathway_Homo sapiens_hsa046600.46670272
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46067706
82Renin-angiotensin system_Homo sapiens_hsa046140.45741494
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45223257
84Peroxisome_Homo sapiens_hsa041460.41829103
85Choline metabolism in cancer_Homo sapiens_hsa052310.39761133
86Sphingolipid metabolism_Homo sapiens_hsa006000.38951947
87mTOR signaling pathway_Homo sapiens_hsa041500.38619144
88Inositol phosphate metabolism_Homo sapiens_hsa005620.36802339
89Acute myeloid leukemia_Homo sapiens_hsa052210.35642179
90Regulation of autophagy_Homo sapiens_hsa041400.35094112
91MAPK signaling pathway_Homo sapiens_hsa040100.34748233
92Endometrial cancer_Homo sapiens_hsa052130.33848500
93Small cell lung cancer_Homo sapiens_hsa052220.33684549
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.31521568
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31039696
96Pancreatic cancer_Homo sapiens_hsa052120.28846990
97Platelet activation_Homo sapiens_hsa046110.28032776
98Chronic myeloid leukemia_Homo sapiens_hsa052200.27332085
99One carbon pool by folate_Homo sapiens_hsa006700.26771368
100Viral carcinogenesis_Homo sapiens_hsa052030.26515988
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25953095
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.25820197
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25538331
104Arachidonic acid metabolism_Homo sapiens_hsa005900.25121384
105Colorectal cancer_Homo sapiens_hsa052100.24887782
106Rap1 signaling pathway_Homo sapiens_hsa040150.24165456
107Histidine metabolism_Homo sapiens_hsa003400.23651324
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.23026508
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22782176
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22651051
111Notch signaling pathway_Homo sapiens_hsa043300.21587544
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21081231
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20882997
114Type II diabetes mellitus_Homo sapiens_hsa049300.19434361
115Fructose and mannose metabolism_Homo sapiens_hsa000510.18902694
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18703252
117p53 signaling pathway_Homo sapiens_hsa041150.18584350
118Galactose metabolism_Homo sapiens_hsa000520.18074669
119Endocytosis_Homo sapiens_hsa041440.17517676
120Insulin resistance_Homo sapiens_hsa049310.16915590
121beta-Alanine metabolism_Homo sapiens_hsa004100.15833286
122Prolactin signaling pathway_Homo sapiens_hsa049170.15811128

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