AOC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)9.49954203
2regulation of sequestering of triglyceride (GO:0010889)8.34539407
3triglyceride catabolic process (GO:0019433)7.84104220
4white fat cell differentiation (GO:0050872)7.48052508
5brown fat cell differentiation (GO:0050873)7.23545870
6neutral lipid catabolic process (GO:0046461)7.00637924
7acylglycerol catabolic process (GO:0046464)7.00637924
8valine metabolic process (GO:0006573)6.70908704
9biotin metabolic process (GO:0006768)6.41032191
10lipid particle organization (GO:0034389)5.83380440
11fatty acid transmembrane transport (GO:1902001)5.76576036
12regulation of cholesterol storage (GO:0010885)5.65618405
13positive regulation of fatty acid oxidation (GO:0046321)5.55411558
14positive regulation of fatty acid beta-oxidation (GO:0032000)5.54580072
15triglyceride biosynthetic process (GO:0019432)5.39474019
16protein heterotrimerization (GO:0070208)5.37208760
17negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.30815285
18carnitine shuttle (GO:0006853)5.27095957
19glycerolipid catabolic process (GO:0046503)5.19037130
20neutral lipid biosynthetic process (GO:0046460)5.17264176
21acylglycerol biosynthetic process (GO:0046463)5.17264176
22lipid storage (GO:0019915)4.77758935
23fatty acid beta-oxidation (GO:0006635)4.76124446
24ethanol oxidation (GO:0006069)4.69865638
25response to dietary excess (GO:0002021)4.52523200
26branched-chain amino acid metabolic process (GO:0009081)4.41548043
27polyol transport (GO:0015791)4.40611427
28ovulation from ovarian follicle (GO:0001542)4.40024696
29regulation of fatty acid oxidation (GO:0046320)4.33378718
30negative regulation of protein autophosphorylation (GO:0031953)4.26517673
31carnitine transmembrane transport (GO:1902603)4.23748972
32branched-chain amino acid catabolic process (GO:0009083)4.22340723
33triglyceride metabolic process (GO:0006641)4.20954662
34fatty acid oxidation (GO:0019395)4.17505361
35regulation of fatty acid beta-oxidation (GO:0031998)4.16212875
36fatty-acyl-CoA biosynthetic process (GO:0046949)4.14926483
37thioester biosynthetic process (GO:0035384)4.12068036
38acyl-CoA biosynthetic process (GO:0071616)4.12068036
39positive regulation of cellular response to insulin stimulus (GO:1900078)4.10195494
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.09622622
41lipid oxidation (GO:0034440)4.09443444
42regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.05138898
43fatty-acyl-CoA metabolic process (GO:0035337)4.04611357
44retina vasculature morphogenesis in camera-type eye (GO:0061299)4.03801454
45transcytosis (GO:0045056)4.02665604
46long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.01317121
47fatty acid catabolic process (GO:0009062)4.00239493
48coenzyme A biosynthetic process (GO:0015937)3.98937067
49acylglycerol metabolic process (GO:0006639)3.97309197
50negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.95225001
51positive regulation of fatty acid metabolic process (GO:0045923)3.95021188
52fatty acid homeostasis (GO:0055089)3.94937532
53negative regulation of granulocyte differentiation (GO:0030853)3.91572037
54neutral lipid metabolic process (GO:0006638)3.91545034
55regulation of macrophage derived foam cell differentiation (GO:0010743)3.91073091
56amino-acid betaine transport (GO:0015838)3.86887146
57carnitine transport (GO:0015879)3.86887146
58negative regulation of phagocytosis (GO:0050765)3.80377917
59plasma lipoprotein particle clearance (GO:0034381)3.79758953
60negative regulation of lipid storage (GO:0010888)3.79359149
61positive regulation of glucose import (GO:0046326)3.79148187
62negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.78829610
63regulation of cAMP-dependent protein kinase activity (GO:2000479)3.78151786
64positive regulation of lipid catabolic process (GO:0050996)3.76903335
65positive regulation of glomerulus development (GO:0090193)3.72781857
66cellular response to lithium ion (GO:0071285)3.72703857
67CDP-diacylglycerol metabolic process (GO:0046341)3.69764108
68alpha-linolenic acid metabolic process (GO:0036109)3.69525259
69positive regulation of lipid storage (GO:0010884)3.69016495
70ethanol metabolic process (GO:0006067)3.68618813
71growth hormone receptor signaling pathway (GO:0060396)3.64097827
72cellular response to epinephrine stimulus (GO:0071872)3.59802332
73tricarboxylic acid metabolic process (GO:0072350)3.57133024
74acetyl-CoA metabolic process (GO:0006084)3.54810415
75regulation of glycogen (starch) synthase activity (GO:2000465)3.53095601
76primary alcohol metabolic process (GO:0034308)3.51143497
77positive regulation of insulin receptor signaling pathway (GO:0046628)3.50510773
78response to phenylpropanoid (GO:0080184)3.50287718
79response to epinephrine (GO:0071871)3.47586741
80pentose-phosphate shunt (GO:0006098)3.44766944
81NADH metabolic process (GO:0006734)3.44128275
82intracellular lipid transport (GO:0032365)3.43025225
83phospholipid homeostasis (GO:0055091)3.41404805
84oxaloacetate metabolic process (GO:0006107)3.40304020
85negative regulation of macrophage differentiation (GO:0045650)3.40074663
86positive regulation of cholesterol efflux (GO:0010875)3.39648868
87NADPH regeneration (GO:0006740)3.38251015
88complement activation, alternative pathway (GO:0006957)3.36816117
89negative regulation of gluconeogenesis (GO:0045721)3.36665453
90cGMP-mediated signaling (GO:0019934)3.32906492
91acyl-CoA metabolic process (GO:0006637)3.32468262
92thioester metabolic process (GO:0035383)3.32468262
93positive regulation of cholesterol transport (GO:0032376)3.31004690
94positive regulation of sterol transport (GO:0032373)3.31004690
95triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30757941
96glycerol metabolic process (GO:0006071)3.29790235
97glomerular filtration (GO:0003094)3.29701020
98cellular response to growth hormone stimulus (GO:0071378)3.27448298
99regulation of lipid storage (GO:0010883)3.26146113
100L-serine transport (GO:0015825)3.25698657
101CDP-diacylglycerol biosynthetic process (GO:0016024)3.25101682
102positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.23524711
103regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.23480030
104triglyceride homeostasis (GO:0070328)3.22569419
105acylglycerol homeostasis (GO:0055090)3.22569419
106positive regulation of lipoprotein lipase activity (GO:0051006)3.21910418
107positive regulation of triglyceride lipase activity (GO:0061365)3.21910418
108negative regulation of DNA biosynthetic process (GO:2000279)3.21588945
109retinol metabolic process (GO:0042572)3.21040734
110positive regulation of glucose transport (GO:0010828)3.19529725
111phosphatidic acid metabolic process (GO:0046473)3.19142980
112phosphatidic acid biosynthetic process (GO:0006654)3.19142980
113diacylglycerol metabolic process (GO:0046339)3.18979072
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18491568
115negative regulation of metanephros development (GO:0072217)3.17674852
116positive regulation of glycolytic process (GO:0045821)3.17618311
117cellular response to vitamin (GO:0071295)3.14311495
118regulation of triglyceride catabolic process (GO:0010896)3.10628681
119long-chain fatty acid transport (GO:0015909)3.10133087
120fat cell differentiation (GO:0045444)3.09278627
121apoptotic cell clearance (GO:0043277)3.08634570
122negative regulation of smooth muscle cell migration (GO:0014912)3.06630356
123negative regulation of smooth muscle cell proliferation (GO:0048662)3.05370452
124linoleic acid metabolic process (GO:0043651)3.03813745
125tricarboxylic acid cycle (GO:0006099)3.03771955
126regulation of triglyceride metabolic process (GO:0090207)2.96348241
127protein localization to cell surface (GO:0034394)2.94818678
128endocrine hormone secretion (GO:0060986)2.94444152
129regulation of cholesterol efflux (GO:0010874)2.90382518
130positive regulation of triglyceride metabolic process (GO:0090208)2.87792384
131regulation of triglyceride biosynthetic process (GO:0010866)2.87040340
132regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.86961317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.02026052
2CLOCK_20551151_ChIP-Seq_293T_Human4.70274902
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.18588542
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.89071389
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56394045
6PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.52862272
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.28951511
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.28787970
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27665033
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.24070912
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.11237847
12CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.02862810
13* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.01289771
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse14.1508125
15PPARA_22158963_ChIP-Seq_LIVER_Mouse1.90979219
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80852501
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79829856
18PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70414005
19GATA1_22025678_ChIP-Seq_K562_Human1.67206770
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60797631
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52465905
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52334241
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46953977
24TBX20_22080862_ChIP-Seq_HEART_Mouse1.44879396
25TBX20_22328084_ChIP-Seq_HEART_Mouse1.44879396
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44203012
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43206125
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.41214448
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39840520
30ZNF263_19887448_ChIP-Seq_K562_Human1.39594578
31CJUN_26792858_Chip-Seq_BT549_Human1.38550365
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36912567
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34849800
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34545493
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31235801
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.28291006
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.27744788
38LXR_22292898_ChIP-Seq_THP-1_Human1.22416810
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.20952123
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17395352
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10653927
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10220343
43VDR_24787735_ChIP-Seq_THP-1_Human1.07666785
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.06666243
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01816432
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01600617
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01572046
48SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00130408
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99069453
50SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98932546
51CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98454064
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98417725
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98038064
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98032935
55NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97738136
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97738136
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96988208
58EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96392573
59RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96392573
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94914232
61RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94559758
62SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94207106
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93713297
64P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91717707
65ERG_21242973_ChIP-ChIP_JURKAT_Human0.91458104
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91185559
67ESR1_21235772_ChIP-Seq_MCF-7_Human0.90869750
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90794519
69SA1_22415368_ChIP-Seq_MEFs_Mouse0.90702829
70EED_16625203_ChIP-ChIP_MESCs_Mouse0.88793976
71RXR_22108803_ChIP-Seq_LS180_Human0.88615562
72SMAD_19615063_ChIP-ChIP_OVARY_Human0.87379972
73GATA1_19941826_ChIP-Seq_K562_Human0.85777973
74FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.85169611
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83986530
76KDM2B_26808549_Chip-Seq_DND41_Human0.83827357
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82500491
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82393762
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.81721467
80FOXA2_19822575_ChIP-Seq_HepG2_Human0.81540474
81P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81296115
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81193738
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80099266
84SOX2_20726797_ChIP-Seq_SW620_Human0.80018950
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80010120
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79761020
87ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79535661
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78805364
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77703053
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77642540
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.77024546
92CTCF_27219007_Chip-Seq_Bcells_Human0.76825930
93TET1_21490601_ChIP-Seq_MESCs_Mouse0.76461433
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76247815
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.76171063
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75951266
97BCAT_22108803_ChIP-Seq_LS180_Human0.75592179
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75333336
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75218771
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74926270
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74228216
102KDM2B_26808549_Chip-Seq_K562_Human0.73780319
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73006026
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72740295
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70139768
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.70051555
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69880378
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.69666045
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.69443238
110PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68531733
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.68347799
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68264095
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66447402
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66378062
115GATA2_19941826_ChIP-Seq_K562_Human0.66245624
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66231549
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.65854514
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.65792601
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65785717
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.65731521
121BRD4_25478319_ChIP-Seq_HGPS_Human0.65320276
122KLF4_19829295_ChIP-Seq_ESCs_Human0.65017844
123GATA3_24758297_ChIP-Seq_MCF-7_Human0.64858746
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.62942341
125DROSHA_22980978_ChIP-Seq_HELA_Human0.62198892
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62109390
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.62075207
128AHR_22903824_ChIP-Seq_MCF-7_Human0.61933940
129RACK7_27058665_Chip-Seq_MCF-7_Human0.61850670
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.61148821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.80903263
2MP0008438_abnormal_cutaneous_collagen5.33567837
3MP0005666_abnormal_adipose_tissue5.29309260
4MP0004130_abnormal_muscle_cell4.78919237
5MP0004185_abnormal_adipocyte_glucose4.70508389
6MP0005375_adipose_tissue_phenotype4.02765168
7MP0005275_abnormal_skin_tensile3.47353081
8MP0000013_abnormal_adipose_tissue3.36005901
9MP0002837_dystrophic_cardiac_calcinosis3.31781721
10MP0002971_abnormal_brown_adipose2.97793396
11MP0000003_abnormal_adipose_tissue2.95945202
12MP0009115_abnormal_fat_cell2.66481686
13MP0002876_abnormal_thyroid_physiology2.65933430
14MP0010329_abnormal_lipoprotein_level2.48597218
15MP0005334_abnormal_fat_pad2.36868924
16MP0004272_abnormal_basement_membrane2.32197007
17MP0003191_abnormal_cellular_cholesterol2.18099212
18MP0001661_extended_life_span2.16686131
19MP0003705_abnormal_hypodermis_morpholog2.15582160
20MP0002970_abnormal_white_adipose2.02880048
21MP0003011_delayed_dark_adaptation1.92961332
22MP0003868_abnormal_feces_composition1.78577785
23MP0002118_abnormal_lipid_homeostasis1.72671928
24MP0003959_abnormal_lean_body1.71383838
25MP0005535_abnormal_body_temperature1.67568099
26MP0004782_abnormal_surfactant_physiolog1.62750943
27MP0003724_increased_susceptibility_to1.59073648
28MP0000751_myopathy1.51323061
29MP0003828_pulmonary_edema1.44271123
30MP0006138_congestive_heart_failure1.43398377
31MP0005448_abnormal_energy_balance1.42947468
32MP0003690_abnormal_glial_cell1.34508425
33MP0010368_abnormal_lymphatic_system1.28338247
34MP0005452_abnormal_adipose_tissue1.27156162
35MP0002060_abnormal_skin_morphology1.27076985
36MP0008775_abnormal_heart_ventricle1.26782653
37MP0003186_abnormal_redox_activity1.18895930
38MP0009780_abnormal_chondrocyte_physiolo1.18343896
39MP0002166_altered_tumor_susceptibility1.16358007
40MP0001881_abnormal_mammary_gland1.15632697
41MP0000750_abnormal_muscle_regeneration1.15216936
42MP0002139_abnormal_hepatobiliary_system1.13851506
43MP0000767_abnormal_smooth_muscle1.12922789
44MP0003045_fibrosis1.12336979
45MP0002078_abnormal_glucose_homeostasis1.09775232
46MP0001544_abnormal_cardiovascular_syste1.08821889
47MP0005385_cardiovascular_system_phenoty1.08821889
48MP0005620_abnormal_muscle_contractility1.08676788
49MP0003566_abnormal_cell_adhesion1.08079924
50MP0000609_abnormal_liver_physiology1.07493649
51MP0000343_altered_response_to1.05961189
52MP0003950_abnormal_plasma_membrane1.04473504
53MP0003279_aneurysm1.01829168
54MP0005647_abnormal_sex_gland1.01740115
55MP0009840_abnormal_foam_cell0.99467308
56MP0004087_abnormal_muscle_fiber0.98478515
57MP0003646_muscle_fatigue0.97777527
58MP0002909_abnormal_adrenal_gland0.97480583
59MP0002933_joint_inflammation0.97218776
60MP0001958_emphysema0.96437087
61MP0005164_abnormal_response_to0.95927723
62MP0001501_abnormal_sleep_pattern0.94414496
63MP0001727_abnormal_embryo_implantation0.92420174
64MP0002006_tumorigenesis0.92142648
65MP0002254_reproductive_system_inflammat0.90721856
66MP0005503_abnormal_tendon_morphology0.90635542
67MP0002108_abnormal_muscle_morphology0.90154750
68MP0000759_abnormal_skeletal_muscle0.87840519
69MP0004215_abnormal_myocardial_fiber0.87192573
70MP0005365_abnormal_bile_salt0.86879171
71MP0001879_abnormal_lymphatic_vessel0.86545523
72MP0002796_impaired_skin_barrier0.83308658
73MP0002295_abnormal_pulmonary_circulatio0.82556997
74MP0002972_abnormal_cardiac_muscle0.81783690
75MP0005330_cardiomyopathy0.81712021
76MP0001756_abnormal_urination0.78217100
77MP0003091_abnormal_cell_migration0.78003204
78MP0004883_abnormal_blood_vessel0.77565792
79MP0003948_abnormal_gas_homeostasis0.74894087
80MP0002168_other_aberrant_phenotype0.74803996
81MP0008961_abnormal_basal_metabolism0.74712245
82MP0002332_abnormal_exercise_endurance0.72833903
83MP0003221_abnormal_cardiomyocyte_apopto0.72655231
84MP0004147_increased_porphyrin_level0.72642889
85MP0005595_abnormal_vascular_smooth0.66786943
86MP0005584_abnormal_enzyme/coenzyme_acti0.65774292
87MP0003075_altered_response_to0.64486752
88MP0000858_altered_metastatic_potential0.64481156
89MP0000230_abnormal_systemic_arterial0.63839621
90MP0000249_abnormal_blood_vessel0.63618273
91MP0003953_abnormal_hormone_level0.63324760
92MP0002638_abnormal_pupillary_reflex0.63218440
93MP0006036_abnormal_mitochondrial_physio0.62007949
94MP0005319_abnormal_enzyme/_coenzyme0.61626238
95MP0005058_abnormal_lysosome_morphology0.60693532
96MP0010630_abnormal_cardiac_muscle0.60585184
97MP0002009_preneoplasia0.60051556
98MP0001177_atelectasis0.59790839
99MP0004036_abnormal_muscle_relaxation0.59277925
100MP0005388_respiratory_system_phenotype0.58593317
101MP0002133_abnormal_respiratory_system0.58593317
102MP0005409_darkened_coat_color0.58357505
103MP0005332_abnormal_amino_acid0.58331621
104MP0001851_eye_inflammation0.56510786
105MP0001764_abnormal_homeostasis0.55878927
106MP0005508_abnormal_skeleton_morphology0.55558665
107MP0002998_abnormal_bone_remodeling0.55510449
108MP0001614_abnormal_blood_vessel0.55475453
109MP0004084_abnormal_cardiac_muscle0.55225938
110MP0000749_muscle_degeneration0.55177344
111MP0004858_abnormal_nervous_system0.55098879
112MP0003448_altered_tumor_morphology0.54815263
113MP0002128_abnormal_blood_circulation0.54762853
114MP0001533_abnormal_skeleton_physiology0.54736041
115MP0005379_endocrine/exocrine_gland_phen0.54669312
116MP0003879_abnormal_hair_cell0.54057408
117MP0001542_abnormal_bone_strength0.53783355
118MP0009643_abnormal_urine_homeostasis0.52586012
119MP0005167_abnormal_blood-brain_barrier0.51811965
120MP0005369_muscle_phenotype0.45449275
121MP0009763_increased_sensitivity_to0.45424399
122MP0005076_abnormal_cell_differentiation0.45322618
123MP0009672_abnormal_birth_weight0.45247558
124MP0002106_abnormal_muscle_physiology0.44120737

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)7.96954002
2Acanthosis nigricans (HP:0000956)6.83488319
3Hypertriglyceridemia (HP:0002155)5.85741225
4Hyperglycinuria (HP:0003108)4.89359054
5Insulin-resistant diabetes mellitus (HP:0000831)4.32307137
6Ankle contracture (HP:0006466)4.27205281
7Difficulty running (HP:0009046)4.23610587
8Increased connective tissue (HP:0009025)4.22074451
9Complement deficiency (HP:0004431)3.99404674
10Abnormality of glycine metabolism (HP:0010895)3.89991075
11Abnormality of serine family amino acid metabolism (HP:0010894)3.89991075
12Type 1 muscle fiber predominance (HP:0003803)3.79126572
13Myoglobinuria (HP:0002913)3.74178303
14Broad metatarsal (HP:0001783)3.71751048
15Long foot (HP:0001833)3.64307764
16Bone cyst (HP:0012062)3.59254424
17Cerebral aneurysm (HP:0004944)3.56281024
18Increased variability in muscle fiber diameter (HP:0003557)3.50128556
19Follicular hyperkeratosis (HP:0007502)3.44313962
20Premature rupture of membranes (HP:0001788)3.40342269
21Reduced subcutaneous adipose tissue (HP:0003758)3.40212809
22Pigmentary retinal degeneration (HP:0001146)3.35058282
23Insulin resistance (HP:0000855)3.30780872
24Aortic dissection (HP:0002647)3.27910138
25Spinal rigidity (HP:0003306)3.22331137
26Growth hormone excess (HP:0000845)3.19271575
27Protrusio acetabuli (HP:0003179)3.15342566
28Polycythemia (HP:0001901)3.14242499
29Hemorrhage of the eye (HP:0011885)3.11353481
30Vertebral compression fractures (HP:0002953)3.09880796
31Abnormality of fatty-acid metabolism (HP:0004359)3.01845143
32Hydroxyprolinuria (HP:0003080)3.01619663
33Abnormality of proline metabolism (HP:0010907)3.01619663
34Aortic aneurysm (HP:0004942)3.00834952
35Subcapsular cataract (HP:0000523)2.97696563
36Abnormality of skeletal muscle fiber size (HP:0012084)2.96454205
37Muscle fiber splitting (HP:0003555)2.95566034
38Increased muscle lipid content (HP:0009058)2.94167258
39Hypoglycemic coma (HP:0001325)2.92072045
40Rhabdomyolysis (HP:0003201)2.89387515
41Hypoalphalipoproteinemia (HP:0003233)2.87464450
42Slender build (HP:0001533)2.87015100
43Myocardial infarction (HP:0001658)2.85553491
44Nausea (HP:0002018)2.82074360
45Abnormality of complement system (HP:0005339)2.79205864
46Epidermoid cyst (HP:0200040)2.79068195
47Ketoacidosis (HP:0001993)2.78575828
48Axonal loss (HP:0003447)2.77159307
49Lipoatrophy (HP:0100578)2.76907797
50Large hands (HP:0001176)2.72868204
51Hyperthyroidism (HP:0000836)2.72244887
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66329892
53Multiple enchondromatosis (HP:0005701)2.64389860
54Back pain (HP:0003418)2.60794256
55Facial shape deformation (HP:0011334)2.60674812
56Potter facies (HP:0002009)2.60674812
57Facial diplegia (HP:0001349)2.58583637
58Lymphangioma (HP:0100764)2.56169043
59Ketosis (HP:0001946)2.48711524
60Hyporeflexia of lower limbs (HP:0002600)2.45155017
61Hyperpituitarism (HP:0010514)2.43690511
62Vascular tortuosity (HP:0004948)2.42495180
63Thyroid-stimulating hormone excess (HP:0002925)2.42471508
64Venous abnormality (HP:0002624)2.41354513
65Pulmonary artery stenosis (HP:0004415)2.40937015
66Glomerulonephritis (HP:0000099)2.39955640
67Skin nodule (HP:0200036)2.36226912
68Hyperlipoproteinemia (HP:0010980)2.34908318
69Soft skin (HP:0000977)2.34754018
70Shallow orbits (HP:0000586)2.34401932
71Wormian bones (HP:0002645)2.30153671
72Increased serum pyruvate (HP:0003542)2.29868005
73Infantile muscular hypotonia (HP:0008947)2.29493441
74Accelerated skeletal maturation (HP:0005616)2.27651716
75Dicarboxylic aciduria (HP:0003215)2.26700181
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26700181
77Right ventricular cardiomyopathy (HP:0011663)2.25949442
78Abnormal cartilage morphology (HP:0002763)2.24534449
79Neck muscle weakness (HP:0000467)2.21219289
80Prenatal maternal abnormality (HP:0002686)2.19558287
81Prominent supraorbital ridges (HP:0000336)2.19328273
82Esophageal varix (HP:0002040)2.18854475
83Decreased subcutaneous fat (HP:0001002)2.17161541
84Hyperglycinemia (HP:0002154)2.16808279
85Abnormal hemoglobin (HP:0011902)2.16205257
86Tetraparesis (HP:0002273)2.15467899
87Interstitial pulmonary disease (HP:0006530)2.15139395
88Aneurysm (HP:0002617)2.14713101
89Pancreatitis (HP:0001733)2.13302301
90Exercise-induced myalgia (HP:0003738)2.11106191
91Hyperammonemia (HP:0001987)2.10203407
92Enlarged penis (HP:0000040)2.08783454
93Cervical subluxation (HP:0003308)2.07603000
94Toxemia of pregnancy (HP:0100603)2.07455973
95Dilatation of the ascending aorta (HP:0005111)2.06909252
96Ileus (HP:0002595)2.06019880
97Joint hemorrhage (HP:0005261)2.05873007
98Amyloidosis (HP:0011034)2.05582225
99Mildly elevated creatine phosphokinase (HP:0008180)2.05152479
100Rectal prolapse (HP:0002035)2.05062438
101Venous insufficiency (HP:0005293)2.03703988
102Mitral valve prolapse (HP:0001634)2.02323186
103Muscle stiffness (HP:0003552)2.00520151
104Asymmetric septal hypertrophy (HP:0001670)2.00421691
105Arterial tortuosity (HP:0005116)2.00352834
106Easy fatigability (HP:0003388)1.98948178
107Abnormality of glycolysis (HP:0004366)1.97426624
108Striae distensae (HP:0001065)1.94571507
109Frequent falls (HP:0002359)1.93009555
110Testicular atrophy (HP:0000029)1.92371006
111Hyperglycemia (HP:0003074)1.92355151
112Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91010076
113Abnormality of the periventricular white matter (HP:0002518)1.90508118
114Abnormality of subcutaneous fat tissue (HP:0001001)1.89985067
115Proximal amyotrophy (HP:0007126)1.89646392
116Systemic lupus erythematosus (HP:0002725)1.89054514
117Xanthomatosis (HP:0000991)1.88857332
118Fragile skin (HP:0001030)1.88248325
119Myotonia (HP:0002486)1.88213192
120Hypoplasia of the iris (HP:0007676)1.87347667
121Colitis (HP:0002583)1.87316377
122Polar cataract (HP:0010696)1.86691871
123Hypercortisolism (HP:0001578)1.86153871
124Hypercholesterolemia (HP:0003124)1.85052294
125Gastrointestinal dysmotility (HP:0002579)1.84361988
126Abnormal eating behavior (HP:0100738)1.83228580
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.82417770
128Osteolytic defects of the hand bones (HP:0009699)1.82417770
129Cerebral inclusion bodies (HP:0100314)1.81995999
130Nephritis (HP:0000123)1.81461028
131Polygenic inheritance (HP:0010982)1.81394016
132Autoimmune thrombocytopenia (HP:0001973)1.79373344
133Ectopia lentis (HP:0001083)1.79181610
134Gowers sign (HP:0003391)1.77952586
135Fibular hypoplasia (HP:0003038)1.77686090
136Deep venous thrombosis (HP:0002625)1.72932539
137Stridor (HP:0010307)1.70413553
138Blue sclerae (HP:0000592)1.69631177
139Pulmonary hypertension (HP:0002092)1.69201575
140Wide anterior fontanel (HP:0000260)1.67445692
141Increased mean platelet volume (HP:0011877)1.67358940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D6.22496646
2TRIB35.35254239
3CAMK1G4.56543540
4SIK14.31369443
5BCKDK3.55110257
6PDK32.90481596
7PDK42.90481596
8RIPK12.72865388
9LMTK22.65777531
10ERN12.24325956
11MST1R2.06708463
12PDGFRA2.02743249
13MYLK2.00072485
14TESK11.93706299
15PRKAA21.82544966
16PDK21.79850626
17FRK1.65264993
18INSRR1.62692276
19FGFR21.59355051
20TTN1.58551378
21FGFR31.58548270
22CDK91.53727904
23MAPK41.50205962
24EPHB21.48512914
25PRPF4B1.41891988
26DDR21.37678755
27TIE11.33167416
28PIK3CA1.32943192
29NLK1.30233033
30TGFBR21.27056157
31PKN21.20911974
32CDC42BPA1.18935380
33LATS11.16416826
34CDK61.11639572
35MAP2K11.06614521
36PRKD31.05867863
37TYK21.05216695
38JAK11.02742040
39MET1.00593638
40PHKG20.96654228
41PHKG10.96654228
42PRKAA10.92311330
43RIPK40.87701399
44PDGFRB0.85453744
45MAP3K130.85021433
46PAK20.84846434
47FER0.84190769
48FGFR40.83083607
49DMPK0.82163155
50MAPK70.81598833
51PTK2B0.80107592
52PTK20.79488586
53NEK90.77710103
54PRKCH0.77592114
55LATS20.75681815
56PDPK10.75399691
57MAP3K60.73572077
58ZAP700.73025205
59STK380.70217598
60JAK20.69770296
61GRK50.69413188
62ILK0.68398107
63IRAK30.65628362
64MTOR0.65575134
65RET0.64765845
66STK38L0.64495402
67MAPK30.63822903
68MAP3K70.63090103
69CAMK10.62658102
70IGF1R0.62134958
71PRKD10.60839458
72MAP3K30.60725404
73GSK3A0.60554055
74FLT30.59352884
75AKT30.57843219
76TYRO30.56782877
77FGFR10.56539679
78PRKACG0.55686843
79MAP3K10.55202988
80CAMKK20.54887509
81PDK10.54526185
82TBK10.52654819
83SGK30.52347485
84MOS0.51440049
85RPS6KA20.51411815
86MAPK110.50677074
87SGK20.50113958
88INSR0.49770776
89BMX0.49521328
90JAK30.49335431
91PRKG10.48923131
92HIPK20.46311702
93PAK40.44994103
94MAP2K30.44459685
95EPHB10.44019174
96ADRBK10.43716244
97KSR20.43459469
98PRKD20.42887286
99SGK4940.42309247
100SGK2230.42309247
101YES10.42175517
102PRKG20.41791859
103DAPK30.41711478
104FES0.39706298
105MAPK10.38928884
106MAP2K40.38772416
107CLK10.38324978
108PINK10.38307443
109ABL20.38203041
110CDK40.37725561
111MARK20.37689566
112RPS6KA30.37136139
113ICK0.35860717
114SRC0.35833821
115KIT0.34746220
116MAPK120.34412692
117TRPM70.33230422
118CSK0.33207846
119EIF2AK20.33205427
120EPHA30.31953660
121RPS6KB10.30072613
122STK30.29192212
123ABL10.27629582
124PTK60.27482707
125ROCK10.27421872
126CSF1R0.27189641
127DAPK20.27178810
128KDR0.26849092
129MAPKAPK30.25825013
130IRAK10.25110809
131TNK20.23856450
132OBSCN0.23351948
133EEF2K0.23243951
134AKT10.20141718
135PIK3CG0.19370172
136PAK30.16875278
137STK110.16818246
138LRRK20.15865622

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.82416013
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.66137479
3PPAR signaling pathway_Homo sapiens_hsa033204.47901008
4Propanoate metabolism_Homo sapiens_hsa006404.46600291
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.74597899
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.49588331
7Fatty acid metabolism_Homo sapiens_hsa012123.48370385
8Glycerolipid metabolism_Homo sapiens_hsa005613.03049282
9Fatty acid degradation_Homo sapiens_hsa000712.86952968
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67714150
11Adipocytokine signaling pathway_Homo sapiens_hsa049202.29130804
12Pyruvate metabolism_Homo sapiens_hsa006202.21170089
13AMPK signaling pathway_Homo sapiens_hsa041522.13136312
14Histidine metabolism_Homo sapiens_hsa003401.90554587
15Carbon metabolism_Homo sapiens_hsa012001.70476522
16Fat digestion and absorption_Homo sapiens_hsa049751.68994414
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64443728
18Caffeine metabolism_Homo sapiens_hsa002321.63922167
19Insulin resistance_Homo sapiens_hsa049311.44044202
20ECM-receptor interaction_Homo sapiens_hsa045121.37439211
21Insulin signaling pathway_Homo sapiens_hsa049101.32721128
22Peroxisome_Homo sapiens_hsa041461.29849902
23Nitrogen metabolism_Homo sapiens_hsa009101.23463840
24* Phenylalanine metabolism_Homo sapiens_hsa003601.18665531
25Butanoate metabolism_Homo sapiens_hsa006501.16226577
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10151418
27Staphylococcus aureus infection_Homo sapiens_hsa051501.09231004
28Renin secretion_Homo sapiens_hsa049241.08057596
29Fatty acid elongation_Homo sapiens_hsa000621.05985727
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05702069
31Glucagon signaling pathway_Homo sapiens_hsa049221.02812604
32Protein digestion and absorption_Homo sapiens_hsa049741.02169593
33* Tyrosine metabolism_Homo sapiens_hsa003501.00564167
34Sulfur relay system_Homo sapiens_hsa041220.96105007
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95967479
36Focal adhesion_Homo sapiens_hsa045100.93643358
37Vitamin B6 metabolism_Homo sapiens_hsa007500.92686029
38* beta-Alanine metabolism_Homo sapiens_hsa004100.92188719
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82722870
40Type II diabetes mellitus_Homo sapiens_hsa049300.81093821
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.80634564
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80352519
43Pentose phosphate pathway_Homo sapiens_hsa000300.76850833
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76352409
45Glycerophospholipid metabolism_Homo sapiens_hsa005640.74096425
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73154980
47Tryptophan metabolism_Homo sapiens_hsa003800.73131809
48Central carbon metabolism in cancer_Homo sapiens_hsa052300.73078367
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60730055
50Retinol metabolism_Homo sapiens_hsa008300.60724577
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60113698
52Notch signaling pathway_Homo sapiens_hsa043300.54364157
53ABC transporters_Homo sapiens_hsa020100.53418879
54Steroid biosynthesis_Homo sapiens_hsa001000.53176198
55HIF-1 signaling pathway_Homo sapiens_hsa040660.52228096
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52123848
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51776599
58Amoebiasis_Homo sapiens_hsa051460.51762428
59Vitamin digestion and absorption_Homo sapiens_hsa049770.50201527
60Lysine degradation_Homo sapiens_hsa003100.50101363
61Starch and sucrose metabolism_Homo sapiens_hsa005000.49613801
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47931528
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46268114
64Complement and coagulation cascades_Homo sapiens_hsa046100.45449310
65Proteoglycans in cancer_Homo sapiens_hsa052050.45069377
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45007494
67cAMP signaling pathway_Homo sapiens_hsa040240.44413829
68Pertussis_Homo sapiens_hsa051330.42879566
69Bile secretion_Homo sapiens_hsa049760.42792296
70mTOR signaling pathway_Homo sapiens_hsa041500.41459691
71Other glycan degradation_Homo sapiens_hsa005110.41089584
72Small cell lung cancer_Homo sapiens_hsa052220.40710211
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40390564
74Dilated cardiomyopathy_Homo sapiens_hsa054140.39359429
75Acute myeloid leukemia_Homo sapiens_hsa052210.39085364
76Autoimmune thyroid disease_Homo sapiens_hsa053200.37823933
77Dorso-ventral axis formation_Homo sapiens_hsa043200.36706903
78Biosynthesis of amino acids_Homo sapiens_hsa012300.35879621
79Viral myocarditis_Homo sapiens_hsa054160.35419380
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33594416
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.33205447
82Melanoma_Homo sapiens_hsa052180.33066803
83Arginine and proline metabolism_Homo sapiens_hsa003300.33004177
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.32951473
85Adherens junction_Homo sapiens_hsa045200.29841421
86Fructose and mannose metabolism_Homo sapiens_hsa000510.29234519
87Toxoplasmosis_Homo sapiens_hsa051450.27939956
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27040228
89Platelet activation_Homo sapiens_hsa046110.26451608
90Arginine biosynthesis_Homo sapiens_hsa002200.25689699
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24802856
92Glutathione metabolism_Homo sapiens_hsa004800.24274527
93GnRH signaling pathway_Homo sapiens_hsa049120.24187388
94Chemical carcinogenesis_Homo sapiens_hsa052040.23931198
95Arachidonic acid metabolism_Homo sapiens_hsa005900.23271694
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22916490
97Salivary secretion_Homo sapiens_hsa049700.22899041
98Ovarian steroidogenesis_Homo sapiens_hsa049130.20849568
99Malaria_Homo sapiens_hsa051440.20116193
100Lysosome_Homo sapiens_hsa041420.19092548
101Linoleic acid metabolism_Homo sapiens_hsa005910.18704940
102Thyroid cancer_Homo sapiens_hsa052160.18218408
103Prion diseases_Homo sapiens_hsa050200.17387645
104Pathways in cancer_Homo sapiens_hsa052000.17292242
105Circadian rhythm_Homo sapiens_hsa047100.17048009
106FoxO signaling pathway_Homo sapiens_hsa040680.16990454
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16644870
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.16540869
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16172048
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.15988709
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15777897
112Renal cell carcinoma_Homo sapiens_hsa052110.15499208
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15497712
114Thyroid hormone synthesis_Homo sapiens_hsa049180.14067487
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14005056
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.13915564
117TGF-beta signaling pathway_Homo sapiens_hsa043500.13728421
118Renin-angiotensin system_Homo sapiens_hsa046140.13238312
119Glioma_Homo sapiens_hsa052140.12864745
120Prolactin signaling pathway_Homo sapiens_hsa049170.12815988
121Estrogen signaling pathway_Homo sapiens_hsa049150.10900154
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10819948
123Hepatitis C_Homo sapiens_hsa051600.10793085
124Chronic myeloid leukemia_Homo sapiens_hsa052200.10677204
125Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10320175
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.10046391
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.09981162
128Tight junction_Homo sapiens_hsa045300.09051141
129Sulfur metabolism_Homo sapiens_hsa009200.08568411
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08439250
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.08389028

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