ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.31935322
2	exogenous drug catabolic process (GO:0042738)	5.97720660
3	drug catabolic process (GO:0042737)	5.69377911
4	negative regulation of cholesterol transport (GO:0032375)	5.04071696
5	negative regulation of sterol transport (GO:0032372)	5.04071696
6	response to pheromone (GO:0019236)	4.75171927
7	glyoxylate metabolic process (GO:0046487)	4.30500408
8	oxidative demethylation (GO:0070989)	4.14483297
9	positive regulation of fatty acid transport (GO:2000193)	4.04020982
10	indole-containing compound catabolic process (GO:0042436)	4.02667691
11	indolalkylamine catabolic process (GO:0046218)	4.02667691
12	tryptophan catabolic process (GO:0006569)	4.02667691
13	aromatic amino acid family catabolic process (GO:0009074)	3.97493843
14	L-phenylalanine catabolic process (GO:0006559)	3.91673264
15	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.91673264
16	arginine metabolic process (GO:0006525)	3.90443492
17	cellular ketone body metabolic process (GO:0046950)	3.88814833
18	intestinal cholesterol absorption (GO:0030299)	3.88364622
19	positive regulation of icosanoid secretion (GO:0032305)	3.85734992
20	positive regulation of prostaglandin secretion (GO:0032308)	3.78342407
21	omega-hydroxylase P450 pathway (GO:0097267)	3.75422973
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.72096094
23	serine family amino acid catabolic process (GO:0009071)	3.70503221
24	epoxygenase P450 pathway (GO:0019373)	3.67668792
25	regulation of fibrinolysis (GO:0051917)	3.62433187
26	regulation of triglyceride catabolic process (GO:0010896)	3.58675868
27	arginine catabolic process (GO:0006527)	3.58222576
28	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.57905784
29	complement activation, alternative pathway (GO:0006957)	3.52872069
30	S-adenosylmethionine metabolic process (GO:0046500)	3.46497275
31	negative regulation of fibrinolysis (GO:0051918)	3.44916609
32	ketone body metabolic process (GO:1902224)	3.43105230
33	regulation of glucokinase activity (GO:0033131)	3.42177315
34	regulation of hexokinase activity (GO:1903299)	3.42177315
35	regulation of protein activation cascade (GO:2000257)	3.41270096
36	imidazole-containing compound metabolic process (GO:0052803)	3.39672490
37	pyrimidine nucleobase catabolic process (GO:0006208)	3.37177579
38	alkaloid metabolic process (GO:0009820)	3.37056671
39	tryptophan metabolic process (GO:0006568)	3.36969015
40	blood coagulation, intrinsic pathway (GO:0007597)	3.32231420
41	high-density lipoprotein particle remodeling (GO:0034375)	3.31984965
42	ethanol oxidation (GO:0006069)	3.28410089
43	cysteine metabolic process (GO:0006534)	3.27659042
44	protein carboxylation (GO:0018214)	3.26675861
45	peptidyl-glutamic acid carboxylation (GO:0017187)	3.26675861
46	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23732112
47	regulation of complement activation (GO:0030449)	3.22852437
48	synaptic transmission, cholinergic (GO:0007271)	3.22737871
49	drug metabolic process (GO:0017144)	3.22636662
50	L-fucose catabolic process (GO:0042355)	3.20745092
51	fucose catabolic process (GO:0019317)	3.20745092
52	L-fucose metabolic process (GO:0042354)	3.20745092
53	regulation of prostaglandin secretion (GO:0032306)	3.20200130
54	bile acid biosynthetic process (GO:0006699)	3.17592550
55	triglyceride homeostasis (GO:0070328)	3.17581878
56	acylglycerol homeostasis (GO:0055090)	3.17581878
57	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.12078981
58	L-phenylalanine metabolic process (GO:0006558)	3.12078981
59	detection of light stimulus involved in sensory perception (GO:0050962)	3.11351249
60	detection of light stimulus involved in visual perception (GO:0050908)	3.11351249
61	indolalkylamine metabolic process (GO:0006586)	3.11003910
62	NAD biosynthetic process (GO:0009435)	3.07056083
63	kynurenine metabolic process (GO:0070189)	3.06834602
64	DNA deamination (GO:0045006)	3.05975825
65	positive regulation of organic acid transport (GO:0032892)	3.03973868
66	protein-lipid complex remodeling (GO:0034368)	3.03646649
67	macromolecular complex remodeling (GO:0034367)	3.03646649
68	plasma lipoprotein particle remodeling (GO:0034369)	3.03646649
69	sulfation (GO:0051923)	3.03174640
70	tyrosine metabolic process (GO:0006570)	2.98681529
71	nucleobase catabolic process (GO:0046113)	2.89884947
72	reverse cholesterol transport (GO:0043691)	2.89549276
73	amino-acid betaine metabolic process (GO:0006577)	2.87078173
74	alpha-amino acid catabolic process (GO:1901606)	2.85084731
75	aromatic amino acid family metabolic process (GO:0009072)	2.82314276
76	amine catabolic process (GO:0009310)	2.78732783
77	cellular biogenic amine catabolic process (GO:0042402)	2.78732783
78	regulation of icosanoid secretion (GO:0032303)	2.75374256
79	bile acid metabolic process (GO:0008206)	2.74757668
80	bile acid and bile salt transport (GO:0015721)	2.74104878
81	aldehyde catabolic process (GO:0046185)	2.73634590
82	heme transport (GO:0015886)	2.72146587
83	cholesterol efflux (GO:0033344)	2.72094105
84	peptidyl-glutamic acid modification (GO:0018200)	2.67979289
85	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.67125795
86	cellular glucuronidation (GO:0052695)	2.65601427
87	negative regulation of telomere maintenance (GO:0032205)	2.62303938
88	kidney morphogenesis (GO:0060993)	2.61541131
89	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.61204426
90	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.61204426
91	ethanol metabolic process (GO:0006067)	2.60874145
92	L-methionine salvage (GO:0071267)	2.60296922
93	L-methionine biosynthetic process (GO:0071265)	2.60296922
94	amino acid salvage (GO:0043102)	2.60296922
95	primary amino compound metabolic process (GO:1901160)	2.60020996
96	negative regulation of astrocyte differentiation (GO:0048712)	2.59048678
97	regulation of cholesterol esterification (GO:0010872)	2.58528530
98	indole-containing compound metabolic process (GO:0042430)	2.58440056
99	uronic acid metabolic process (GO:0006063)	2.57793328
100	glucuronate metabolic process (GO:0019585)	2.57793328

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.99816136
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.54122380
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.14384208
4	VDR_22108803_ChIP-Seq_LS180_Human	2.75552276
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.47011926
6	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.45380699
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27628826
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.12871217
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.98507320
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87848625
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.80037580
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.78655689
13	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71852620
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71111684
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64983525
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.64198307
17	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60916669
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58362455
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.58191007
20	FUS_26573619_Chip-Seq_HEK293_Human	1.57602872
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.54913785
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.54563120
23	P300_19829295_ChIP-Seq_ESCs_Human	1.48883752
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.47619136
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47292129
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.46492661
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45482463
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45309785
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.42344582
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.41178501
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.41178501
32	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.40665093
33	NCOR_22424771_ChIP-Seq_293T_Human	1.39933297
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.38866501
35	AR_20517297_ChIP-Seq_VCAP_Human	1.35579417
36	AR_25329375_ChIP-Seq_VCAP_Human	1.35453445
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34543562
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32072715
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32072715
40	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32011486
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31876130
42	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.31592781
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.31418743
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28889377
45	MYC_19829295_ChIP-Seq_ESCs_Human	1.28880290
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28330652
47	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.28130037
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.28041653
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27805481
50	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.27196396
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26576001
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26149556
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.25796811
54	ERA_21632823_ChIP-Seq_H3396_Human	1.25770605
55	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.25221452
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23140680
57	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23022919
58	DROSHA_22980978_ChIP-Seq_HELA_Human	1.22902117
59	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.21832604
60	STAT3_23295773_ChIP-Seq_U87_Human	1.21449833
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.20562881
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20436959
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20436959
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.19497341
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.19246486
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18613743
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18336751
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17372772
69	CBP_20019798_ChIP-Seq_JUKART_Human	1.17372772
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16826472
71	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.16612413
72	TCF4_23295773_ChIP-Seq_U87_Human	1.16541361
73	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16436284
74	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15508662
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14479901
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.14289497
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14192523
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12683417
79	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12362441
80	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12121451
81	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.10713757
82	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10224826
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09594807
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08548253
85	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08039107
86	EWS_26573619_Chip-Seq_HEK293_Human	1.07578067
87	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07271499
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.06139449
89	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05930974
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05893483
91	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05622440
92	OCT4_20526341_ChIP-Seq_ESCs_Human	1.05500341
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05477271
94	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05422758
95	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03007581
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.02613859
97	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.02582474
98	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02578655
99	MYC_18940864_ChIP-ChIP_HL60_Human	1.02377738
100	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.02205523

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.88890250
2	MP0002139_abnormal_hepatobiliary_system	4.17973924
3	MP0008875_abnormal_xenobiotic_pharmacok	3.94612084
4	MP0005085_abnormal_gallbladder_physiolo	3.25042220
5	MP0005360_urolithiasis	3.04656843
6	MP0002102_abnormal_ear_morphology	2.95222546
7	MP0005365_abnormal_bile_salt	2.93086722
8	MP0010329_abnormal_lipoprotein_level	2.41366916
9	MP0002638_abnormal_pupillary_reflex	2.30053608
10	MP0001968_abnormal_touch/_nociception	2.29665781
11	MP0005551_abnormal_eye_electrophysiolog	2.15455551
12	MP0005646_abnormal_pituitary_gland	1.96690787
13	MP0006292_abnormal_olfactory_placode	1.94531565
14	MP0002735_abnormal_chemical_nociception	1.92174323
15	MP0003011_delayed_dark_adaptation	1.90295955
16	MP0001986_abnormal_taste_sensitivity	1.89487456
17	MP0004885_abnormal_endolymph	1.85414664
18	MP0003252_abnormal_bile_duct	1.83707643
19	MP0003646_muscle_fatigue	1.82649640
20	MP0002876_abnormal_thyroid_physiology	1.80174319
21	MP0005332_abnormal_amino_acid	1.73677373
22	MP0003122_maternal_imprinting	1.68757566
23	MP0005167_abnormal_blood-brain_barrier	1.61767329
24	MP0008872_abnormal_physiological_respon	1.59609971
25	MP0004147_increased_porphyrin_level	1.57326365
26	MP0009840_abnormal_foam_cell	1.55283751
27	MP0010386_abnormal_urinary_bladder	1.54156789
28	MP0004133_heterotaxia	1.53158200
29	MP0002909_abnormal_adrenal_gland	1.50983022
30	MP0009745_abnormal_behavioral_response	1.50339013
31	MP0000566_synostosis	1.46625583
32	MP0004043_abnormal_pH_regulation	1.43895419
33	MP0001666_abnormal_nutrient_absorption	1.39980958
34	MP0005645_abnormal_hypothalamus_physiol	1.38166571
35	MP0003136_yellow_coat_color	1.34520742
36	MP0008877_abnormal_DNA_methylation	1.32402990
37	MP0005448_abnormal_energy_balance	1.29404793
38	MP0004742_abnormal_vestibular_system	1.29323655
39	MP0006276_abnormal_autonomic_nervous	1.27318936
40	MP0004142_abnormal_muscle_tone	1.25056364
41	MP0004019_abnormal_vitamin_homeostasis	1.21372110
42	MP0002138_abnormal_hepatobiliary_system	1.20964108
43	MP0005084_abnormal_gallbladder_morpholo	1.19207694
44	MP0002938_white_spotting	1.18841722
45	MP0005253_abnormal_eye_physiology	1.17248646
46	MP0002118_abnormal_lipid_homeostasis	1.14764207
47	MP0001485_abnormal_pinna_reflex	1.14395032
48	MP0002557_abnormal_social/conspecific_i	1.14257422
49	MP0005410_abnormal_fertilization	1.11198732
50	MP0000372_irregular_coat_pigmentation	1.10595450
51	MP0004130_abnormal_muscle_cell	1.10038308
52	MP0001905_abnormal_dopamine_level	1.09485267
53	MP0008995_early_reproductive_senescence	1.08294233
54	MP0003879_abnormal_hair_cell	1.07690201
55	MP0003638_abnormal_response/metabolism_	1.07668280
56	MP0002736_abnormal_nociception_after	1.06012602
57	MP0002272_abnormal_nervous_system	1.05165229
58	MP0002837_dystrophic_cardiac_calcinosis	1.03891540
59	MP0002572_abnormal_emotion/affect_behav	1.02944870
60	MP0001486_abnormal_startle_reflex	1.02681785
61	MP0005377_hearing/vestibular/ear_phenot	1.02255165
62	MP0003878_abnormal_ear_physiology	1.02255165
63	MP0003787_abnormal_imprinting	1.01466278
64	MP0009379_abnormal_foot_pigmentation	1.01407408
65	MP0000230_abnormal_systemic_arterial	1.00914679
66	MP0001501_abnormal_sleep_pattern	1.00347281
67	MP0002733_abnormal_thermal_nociception	1.00113235
68	MP0005379_endocrine/exocrine_gland_phen	0.98418486
69	MP0001764_abnormal_homeostasis	0.96363809
70	MP0006072_abnormal_retinal_apoptosis	0.95190683
71	MP0002277_abnormal_respiratory_mucosa	0.92598304
72	MP0002064_seizures	0.91615245
73	MP0000026_abnormal_inner_ear	0.91191319
74	MP0005083_abnormal_biliary_tract	0.90695967
75	MP0001970_abnormal_pain_threshold	0.90386794
76	MP0002282_abnormal_trachea_morphology	0.90074646
77	MP0005386_behavior/neurological_phenoty	0.87639855
78	MP0004924_abnormal_behavior	0.87639855
79	MP0009643_abnormal_urine_homeostasis	0.86248617
80	MP0005670_abnormal_white_adipose	0.85257646
81	MP0003880_abnormal_central_pattern	0.83974731
82	MP0008775_abnormal_heart_ventricle	0.82960392
83	MP0005423_abnormal_somatic_nervous	0.82026656
84	MP0000427_abnormal_hair_cycle	0.82002577
85	MP0005195_abnormal_posterior_eye	0.78117495
86	MP0002067_abnormal_sensory_capabilities	0.77808978
87	MP0001984_abnormal_olfaction	0.77688924
88	MP0002063_abnormal_learning/memory/cond	0.77245227
89	MP0009046_muscle_twitch	0.77094303
90	MP0005636_abnormal_mineral_homeostasis	0.76972520
91	MP0003890_abnormal_embryonic-extraembry	0.76694049
92	MP0002653_abnormal_ependyma_morphology	0.75289745
93	MP0000631_abnormal_neuroendocrine_gland	0.74845725
94	MP0001440_abnormal_grooming_behavior	0.74192333
95	MP0003718_maternal_effect	0.73945681
96	MP0001963_abnormal_hearing_physiology	0.72367581
97	MP0002078_abnormal_glucose_homeostasis	0.72198817
98	MP0000639_abnormal_adrenal_gland	0.70232115
99	MP0002734_abnormal_mechanical_nocicepti	0.70109186
100	MP0009115_abnormal_fat_cell	0.69200549

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	4.30668679
2	Birth length less than 3rd percentile (HP:0003561)	4.16150181
3	Congenital stationary night blindness (HP:0007642)	3.92570834
4	Hyperlipoproteinemia (HP:0010980)	3.65937226
5	Attenuation of retinal blood vessels (HP:0007843)	3.51419482
6	Abnormality of midbrain morphology (HP:0002418)	3.48247161
7	Molar tooth sign on MRI (HP:0002419)	3.48247161
8	Pancreatic cysts (HP:0001737)	3.33025977
9	Deep venous thrombosis (HP:0002625)	3.19594885
10	Complement deficiency (HP:0004431)	3.14221136
11	Joint hemorrhage (HP:0005261)	3.13613510
12	Abnormality of the renal cortex (HP:0011035)	3.11894202
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.10204965
14	Nephronophthisis (HP:0000090)	3.09609509
15	Pancreatic fibrosis (HP:0100732)	3.02164003
16	Hypobetalipoproteinemia (HP:0003563)	3.00730958
17	True hermaphroditism (HP:0010459)	2.97397867
18	Chronic hepatic failure (HP:0100626)	2.96491236
19	Hyperglycinuria (HP:0003108)	2.96227127
20	Hyperalaninemia (HP:0003348)	2.88709071
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88709071
22	Abnormality of alanine metabolism (HP:0010916)	2.88709071
23	Xanthomatosis (HP:0000991)	2.83986021
24	Hyperglycinemia (HP:0002154)	2.81308362
25	Abolished electroretinogram (ERG) (HP:0000550)	2.79567855
26	Generalized aminoaciduria (HP:0002909)	2.76699637
27	Abnormality of glycine metabolism (HP:0010895)	2.76602420
28	Abnormality of serine family amino acid metabolism (HP:0010894)	2.76602420
29	Abnormal biliary tract physiology (HP:0012439)	2.73601043
30	Bile duct proliferation (HP:0001408)	2.73601043
31	Abnormality of the renal medulla (HP:0100957)	2.72401641
32	Pendular nystagmus (HP:0012043)	2.69409282
33	Abnormal drinking behavior (HP:0030082)	2.65826726
34	Polydipsia (HP:0001959)	2.65826726
35	Renal cortical cysts (HP:0000803)	2.65688879
36	Concave nail (HP:0001598)	2.62626117
37	Bony spicule pigmentary retinopathy (HP:0007737)	2.49044689
38	Type II lissencephaly (HP:0007260)	2.48634563
39	Decreased circulating renin level (HP:0003351)	2.47324911
40	Delayed CNS myelination (HP:0002188)	2.43229593
41	Lissencephaly (HP:0001339)	2.43221373
42	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.41769722
43	Polyuria (HP:0000103)	2.33848403
44	Hyperventilation (HP:0002883)	2.32147060
45	Protruding tongue (HP:0010808)	2.30658469
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30093873
47	Absent/shortened dynein arms (HP:0200106)	2.30093873
48	Patellar aplasia (HP:0006443)	2.28292988
49	Medial flaring of the eyebrow (HP:0010747)	2.27380174
50	Tubular atrophy (HP:0000092)	2.26817277
51	Conjugated hyperbilirubinemia (HP:0002908)	2.26467189
52	Hypothermia (HP:0002045)	2.26358311
53	Arthropathy (HP:0003040)	2.24953674
54	Abnormal urine output (HP:0012590)	2.24139346
55	Abnormal respiratory epithelium morphology (HP:0012253)	2.23560017
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.23560017
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.18402774
58	Abnormality of urine glucose concentration (HP:0011016)	2.15613662
59	Glycosuria (HP:0003076)	2.15613662
60	Abnormality of proline metabolism (HP:0010907)	2.14548724
61	Hydroxyprolinuria (HP:0003080)	2.14548724
62	Aplasia/Hypoplasia of the patella (HP:0006498)	2.12971860
63	Inability to walk (HP:0002540)	2.11436065
64	Renal Fanconi syndrome (HP:0001994)	2.11231602
65	Increased corneal curvature (HP:0100692)	2.10452071
66	Keratoconus (HP:0000563)	2.10452071
67	Spontaneous abortion (HP:0005268)	2.10251485
68	Epidermoid cyst (HP:0200040)	2.08422573
69	Cystic liver disease (HP:0006706)	2.07966333
70	Decreased central vision (HP:0007663)	2.06662488
71	Hypoglycemic seizures (HP:0002173)	2.04646229
72	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.04392121
73	Abnormality of serum amino acid levels (HP:0003112)	2.00938965
74	Breast hypoplasia (HP:0003187)	1.98328591
75	Gait imbalance (HP:0002141)	1.97056358
76	Chorioretinal atrophy (HP:0000533)	1.90782301
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90376454
78	Stomach cancer (HP:0012126)	1.88730340
79	Optic disc pallor (HP:0000543)	1.87501378
80	Abnormality of the pons (HP:0007361)	1.87165264
81	Progressive inability to walk (HP:0002505)	1.85694853
82	Abnormality of renal excretion (HP:0011036)	1.84671013
83	Abnormal ciliary motility (HP:0012262)	1.84118108
84	Abnormality of complement system (HP:0005339)	1.83884601
85	Congenital sensorineural hearing impairment (HP:0008527)	1.83544685
86	Furrowed tongue (HP:0000221)	1.78878113
87	Congenital primary aphakia (HP:0007707)	1.78682620
88	Increased hepatocellular lipid droplets (HP:0006565)	1.78341853
89	Pigmentary retinal degeneration (HP:0001146)	1.77976286
90	Hypophosphatemic rickets (HP:0004912)	1.77483696
91	Pachygyria (HP:0001302)	1.77158955
92	Recurrent corneal erosions (HP:0000495)	1.75510547
93	Large for gestational age (HP:0001520)	1.74928216
94	Glomerulonephritis (HP:0000099)	1.74140771
95	Congenital, generalized hypertrichosis (HP:0004540)	1.72824390
96	Nephrogenic diabetes insipidus (HP:0009806)	1.72331652
97	Hypoplasia of the pons (HP:0012110)	1.70643295
98	Acute encephalopathy (HP:0006846)	1.69320829
99	Ketosis (HP:0001946)	1.67268523
100	Hyperphosphaturia (HP:0003109)	1.66681911

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.67326938
2	ADRBK2	3.62186159
3	ACVR1B	3.57713161
4	WNK4	3.50165190
5	INSRR	3.19860806
6	CASK	3.11612295
7	WNK3	3.09233891
8	ZAK	2.97737909
9	BMPR1B	2.70462455
10	PINK1	2.67908088
11	FRK	2.64052151
12	MAP4K2	2.29829242
13	TAOK3	2.20369259
14	GRK1	2.18739582
15	DAPK2	2.16445671
16	NTRK3	1.99439796
17	MARK1	1.97322077
18	TXK	1.81568139
19	STK39	1.74111196
20	MAPK13	1.65098711
21	PIK3CA	1.53529025
22	MUSK	1.50354357
23	ADRBK1	1.39418807
24	OXSR1	1.37471882
25	TGFBR1	1.27946371
26	NUAK1	1.23385536
27	MAP3K4	1.20137787
28	DYRK2	1.18393379
29	MAP2K6	1.17533772
30	SIK2	1.05481956
31	PAK3	0.99550552
32	FGFR2	0.97938301
33	ERBB2	0.97678021
34	PRKCG	0.97505959
35	TNIK	0.97298285
36	BCKDK	0.92073391
37	PHKG2	0.89836817
38	PHKG1	0.89836817
39	MAP2K7	0.88413987
40	PNCK	0.83306613
41	ABL2	0.81198029
42	MAP2K4	0.80177254
43	MAPKAPK3	0.79554053
44	TNK2	0.78277330
45	NTRK2	0.77147101
46	PRKAA2	0.76595872
47	TIE1	0.76574881
48	VRK1	0.75127859
49	EPHB2	0.72842169
50	CAMKK2	0.66829862
51	PRKACA	0.64122843
52	CAMKK1	0.63126125
53	RPS6KA5	0.61734488
54	NME1	0.60837826
55	MAPK15	0.60463166
56	STK11	0.57806138
57	CAMK1	0.57344931
58	DYRK1B	0.57208600
59	MAP2K1	0.56956152
60	PRKCE	0.56559308
61	PRKAA1	0.55465008
62	GRK7	0.55010697
63	OBSCN	0.53971887
64	PRKCZ	0.52785621
65	CAMK2A	0.52440006
66	PRKACG	0.52349845
67	TEC	0.51848124
68	DYRK1A	0.51453378
69	MAP2K2	0.51272470
70	PRKG1	0.51060973
71	EPHA4	0.46755903
72	MAP3K11	0.46379846
73	PRKCQ	0.45826489
74	IKBKB	0.45048674
75	PKN1	0.44793202
76	STK38L	0.44051012
77	CHUK	0.43839658
78	PRKD2	0.41907199
79	PRKACB	0.38418437
80	PRKG2	0.37479148
81	EPHA3	0.37291264
82	PTK2B	0.36066833
83	KIT	0.35683684
84	PRKCA	0.35475084
85	RPS6KA6	0.35217347
86	CSNK1A1	0.34868441
87	WNK1	0.33430009
88	PLK4	0.33177119
89	ITK	0.33028647
90	CAMK1D	0.32721719
91	MAPKAPK5	0.32719652
92	CSNK1D	0.31581273
93	IGF1R	0.30797568
94	CAMK1G	0.30723183
95	CSNK1E	0.28304497
96	NEK1	0.28303859
97	CLK1	0.27082333
98	SYK	0.25153014
99	MATK	0.24063868
100	LYN	0.23978657

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.63009652
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.14162949
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.82243028
4	Butanoate metabolism_Homo sapiens_hsa00650	2.67458820
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.54798139
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.53183657
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.52517593
8	Complement and coagulation cascades_Homo sapiens_hsa04610	2.47204769
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.45983840
10	Chemical carcinogenesis_Homo sapiens_hsa05204	2.35353957
11	Retinol metabolism_Homo sapiens_hsa00830	2.30620995
12	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.15025661
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.09837775
14	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.05091660
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.03634557
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.98975912
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93604521
18	Fat digestion and absorption_Homo sapiens_hsa04975	1.93391207
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.86327550
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.82948457
21	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.78135210
22	Phototransduction_Homo sapiens_hsa04744	1.66908517
23	Fatty acid degradation_Homo sapiens_hsa00071	1.63733838
24	Sulfur relay system_Homo sapiens_hsa04122	1.63568672
25	ABC transporters_Homo sapiens_hsa02010	1.61732802
26	Arginine biosynthesis_Homo sapiens_hsa00220	1.58690815
27	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.58163555
28	Histidine metabolism_Homo sapiens_hsa00340	1.54894756
29	Tyrosine metabolism_Homo sapiens_hsa00350	1.50691894
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.49675891
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46654830
32	Peroxisome_Homo sapiens_hsa04146	1.41518399
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.38480295
34	Bile secretion_Homo sapiens_hsa04976	1.35666068
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29862332
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.27557645
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27093535
38	Propanoate metabolism_Homo sapiens_hsa00640	1.25243556
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.24462875
40	Oxidative phosphorylation_Homo sapiens_hsa00190	1.22674755
41	PPAR signaling pathway_Homo sapiens_hsa03320	1.15488364
42	One carbon pool by folate_Homo sapiens_hsa00670	1.14422502
43	Phenylalanine metabolism_Homo sapiens_hsa00360	1.14392475
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.10951443
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07453481
46	Nicotine addiction_Homo sapiens_hsa05033	1.05886255
47	Selenocompound metabolism_Homo sapiens_hsa00450	1.03506547
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02904480
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99817712
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.97339994
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.95755155
52	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.90475719
53	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89491334
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88677850
55	Parkinsons disease_Homo sapiens_hsa05012	0.87328593
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.84170341
57	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84072385
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83567219
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.81807660
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.80531630
61	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79710456
62	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.78388156
63	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.71936754
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.71004721
65	Olfactory transduction_Homo sapiens_hsa04740	0.68744839
66	Serotonergic synapse_Homo sapiens_hsa04726	0.67490073
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66987922
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65841852
69	Taste transduction_Homo sapiens_hsa04742	0.65333034
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65172726
71	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62231179
72	Metabolic pathways_Homo sapiens_hsa01100	0.60775696
73	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58845590
74	Sulfur metabolism_Homo sapiens_hsa00920	0.55367981
75	Morphine addiction_Homo sapiens_hsa05032	0.54021023
76	GABAergic synapse_Homo sapiens_hsa04727	0.54018284
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53490757
78	Alzheimers disease_Homo sapiens_hsa05010	0.52702158
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52475540
80	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47629167
81	Circadian entrainment_Homo sapiens_hsa04713	0.46280604
82	Regulation of autophagy_Homo sapiens_hsa04140	0.43947042
83	Insulin secretion_Homo sapiens_hsa04911	0.42040488
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41831076
85	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.38957827
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.37850553
87	Ribosome_Homo sapiens_hsa03010	0.37639367
88	Huntingtons disease_Homo sapiens_hsa05016	0.35786667
89	Mineral absorption_Homo sapiens_hsa04978	0.35696149
90	RNA polymerase_Homo sapiens_hsa03020	0.35037273
91	Basal transcription factors_Homo sapiens_hsa03022	0.34649385
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.33662401
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29065970
94	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.28789887
95	Protein export_Homo sapiens_hsa03060	0.26919545
96	Cocaine addiction_Homo sapiens_hsa05030	0.25417734
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.21463213
98	Homologous recombination_Homo sapiens_hsa03440	0.18981919
99	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.15995979
100	Primary immunodeficiency_Homo sapiens_hsa05340	0.15914656

AOC4P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »