AOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.41287963
2drug catabolic process (GO:0042737)8.51007672
3omega-hydroxylase P450 pathway (GO:0097267)8.05071267
4L-phenylalanine catabolic process (GO:0006559)6.90141140
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90141140
6L-phenylalanine metabolic process (GO:0006558)6.60943516
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.60943516
8aromatic amino acid family catabolic process (GO:0009074)6.34813449
9tryptophan catabolic process (GO:0006569)5.92100618
10indole-containing compound catabolic process (GO:0042436)5.92100618
11indolalkylamine catabolic process (GO:0046218)5.92100618
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80582625
13kynurenine metabolic process (GO:0070189)5.79141173
14bile acid biosynthetic process (GO:0006699)5.69129966
15alpha-linolenic acid metabolic process (GO:0036109)5.65585507
16drug metabolic process (GO:0017144)5.62041716
17tryptophan metabolic process (GO:0006568)5.55472607
18complement activation, alternative pathway (GO:0006957)5.49332428
19opsonization (GO:0008228)5.46030522
20blood coagulation, intrinsic pathway (GO:0007597)5.35990372
21oxidative demethylation (GO:0070989)5.35931872
22glyoxylate metabolic process (GO:0046487)5.33131609
23regulation of protein activation cascade (GO:2000257)5.28871264
24urea cycle (GO:0000050)5.26209332
25urea metabolic process (GO:0019627)5.26209332
26sulfur amino acid catabolic process (GO:0000098)5.24109654
27glucocorticoid biosynthetic process (GO:0006704)5.17403988
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12766266
29peptidyl-glutamic acid carboxylation (GO:0017187)5.04530225
30protein carboxylation (GO:0018214)5.04530225
31negative regulation of fibrinolysis (GO:0051918)5.04409202
32regulation of complement activation (GO:0030449)5.02486503
33regulation of plasminogen activation (GO:0010755)4.96016105
34cysteine metabolic process (GO:0006534)4.92321241
35regulation of humoral immune response (GO:0002920)4.91124226
36regulation of fibrinolysis (GO:0051917)4.90447216
37high-density lipoprotein particle remodeling (GO:0034375)4.90196289
38negative regulation of protein activation cascade (GO:2000258)4.89772873
39bile acid metabolic process (GO:0008206)4.84793618
40nitrogen cycle metabolic process (GO:0071941)4.84216391
41regulation of triglyceride catabolic process (GO:0010896)4.82665627
42serine family amino acid catabolic process (GO:0009071)4.68968604
43coenzyme catabolic process (GO:0009109)4.65602347
44acute-phase response (GO:0006953)4.61287932
45ethanol metabolic process (GO:0006067)4.60784771
46acylglycerol homeostasis (GO:0055090)4.60432022
47triglyceride homeostasis (GO:0070328)4.60432022
48aromatic amino acid family metabolic process (GO:0009072)4.59163849
49amino-acid betaine metabolic process (GO:0006577)4.52154138
50negative regulation of hemostasis (GO:1900047)4.51375277
51negative regulation of blood coagulation (GO:0030195)4.51375277
52lysine metabolic process (GO:0006553)4.50481437
53lysine catabolic process (GO:0006554)4.50481437
54homocysteine metabolic process (GO:0050667)4.45032957
55tyrosine metabolic process (GO:0006570)4.40366502
56alpha-amino acid catabolic process (GO:1901606)4.39556217
57regulation of apoptotic cell clearance (GO:2000425)4.39375094
58reverse cholesterol transport (GO:0043691)4.38513626
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.35601157
60phenylpropanoid metabolic process (GO:0009698)4.33819855
61protein-lipid complex remodeling (GO:0034368)4.30828201
62macromolecular complex remodeling (GO:0034367)4.30828201
63plasma lipoprotein particle remodeling (GO:0034369)4.30828201
64plasma lipoprotein particle clearance (GO:0034381)4.29031870
65ethanol oxidation (GO:0006069)4.23767812
66indolalkylamine metabolic process (GO:0006586)4.23270440
67S-adenosylmethionine metabolic process (GO:0046500)4.22468691
68regulation of cholesterol esterification (GO:0010872)4.21013322
69intestinal cholesterol absorption (GO:0030299)4.18104344
70phospholipid efflux (GO:0033700)4.16242742
71negative regulation of coagulation (GO:0050819)4.15323171
72negative regulation of wound healing (GO:0061045)4.13512783
73cellular ketone body metabolic process (GO:0046950)4.12754545
74cellular amino acid catabolic process (GO:0009063)4.10671546
75bile acid and bile salt transport (GO:0015721)4.06543600
76amine catabolic process (GO:0009310)4.05571490
77cellular biogenic amine catabolic process (GO:0042402)4.05571490
78cellular glucuronidation (GO:0052695)4.03992621
79imidazole-containing compound metabolic process (GO:0052803)4.03396049
80androgen biosynthetic process (GO:0006702)4.03126581
81cellular modified amino acid catabolic process (GO:0042219)4.01220035
82acetyl-CoA metabolic process (GO:0006084)3.99131610
83cytolysis (GO:0019835)3.98561614
84disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.96921143
85killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.96921143
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.94597690
87polyketide metabolic process (GO:0030638)3.93372371
88doxorubicin metabolic process (GO:0044598)3.93372371
89daunorubicin metabolic process (GO:0044597)3.93372371
90negative regulation of cholesterol transport (GO:0032375)3.92529506
91negative regulation of sterol transport (GO:0032372)3.92529506
92negative regulation of complement activation (GO:0045916)3.92462017
93fatty acid beta-oxidation (GO:0006635)3.89340486
94benzene-containing compound metabolic process (GO:0042537)3.89210526
95glucocorticoid metabolic process (GO:0008211)3.89048097
96hormone catabolic process (GO:0042447)3.88143765
97glycine metabolic process (GO:0006544)3.87398173
98positive regulation of lipid catabolic process (GO:0050996)3.86857152
99cholesterol efflux (GO:0033344)3.83198223
100glutamate metabolic process (GO:0006536)3.82531241
101fatty acid oxidation (GO:0019395)3.81558110
102phospholipid homeostasis (GO:0055091)3.81004499
103positive regulation of blood coagulation (GO:0030194)3.78676444
104positive regulation of hemostasis (GO:1900048)3.78676444
105short-chain fatty acid metabolic process (GO:0046459)3.77169515
106complement activation, classical pathway (GO:0006958)3.76063025
107lipid oxidation (GO:0034440)3.75288634
108valine metabolic process (GO:0006573)3.75116240
109dicarboxylic acid biosynthetic process (GO:0043650)3.73741538
110organic acid catabolic process (GO:0016054)3.73301638
111carboxylic acid catabolic process (GO:0046395)3.73301638
112complement activation (GO:0006956)3.72482262
113flavonoid metabolic process (GO:0009812)3.72152623
114serine family amino acid metabolic process (GO:0009069)3.71169576
115fatty acid catabolic process (GO:0009062)3.68708590
116negative regulation of lipase activity (GO:0060192)3.67834547
117response to mercury ion (GO:0046689)3.66977273
118cofactor catabolic process (GO:0051187)3.66737585
119monocarboxylic acid catabolic process (GO:0072329)3.64973154
120positive regulation of triglyceride lipase activity (GO:0061365)3.64524288
121positive regulation of lipoprotein lipase activity (GO:0051006)3.64524288
122fibrinolysis (GO:0042730)3.64236966
123plasma lipoprotein particle assembly (GO:0034377)3.59066952
124low-density lipoprotein particle remodeling (GO:0034374)3.58808605
1252-oxoglutarate metabolic process (GO:0006103)3.58513093
126protein activation cascade (GO:0072376)3.58199586
127ketone body metabolic process (GO:1902224)3.56807172
128xenobiotic metabolic process (GO:0006805)3.56232950
129uronic acid metabolic process (GO:0006063)3.53739232
130glucuronate metabolic process (GO:0019585)3.53739232
131arginine metabolic process (GO:0006525)3.53080168
132epoxygenase P450 pathway (GO:0019373)3.52865279
133very-low-density lipoprotein particle assembly (GO:0034379)3.52334119
134cholesterol homeostasis (GO:0042632)3.51862657
135positive regulation of coagulation (GO:0050820)3.51653038
136aminoglycoside antibiotic metabolic process (GO:0030647)3.51523879
137regulation of cholesterol homeostasis (GO:2000188)3.50180175
138fatty acid transmembrane transport (GO:1902001)3.47388651
139androgen metabolic process (GO:0008209)3.45596304
140alkaloid metabolic process (GO:0009820)3.45358826
141regulation of acute inflammatory response (GO:0002673)3.44235546
142acute inflammatory response (GO:0002526)3.33816557
143fat-soluble vitamin biosynthetic process (GO:0042362)3.30907661
144positive regulation of fatty acid biosynthetic process (GO:0045723)3.30212479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.75485355
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66943394
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.48123041
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.18707643
5* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.00173282
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.99537703
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.41334763
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.18325726
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.42481610
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58487976
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.34775586
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8054375
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91992586
14CLOCK_20551151_ChIP-Seq_293T_Human1.80379588
15GATA1_22025678_ChIP-Seq_K562_Human1.76516406
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66341376
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62921245
18HTT_18923047_ChIP-ChIP_STHdh_Human1.41813011
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41119773
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35152464
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.34592537
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27543068
23TP53_18474530_ChIP-ChIP_U2OS_Human1.21594656
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20706755
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17720084
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17616344
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10927615
28CJUN_26792858_Chip-Seq_BT549_Human1.08937852
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08291118
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07203031
31* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02915515
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.01002878
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95981921
34ESR2_21235772_ChIP-Seq_MCF-7_Human0.95176334
35SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93881979
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93881196
37SMAD_19615063_ChIP-ChIP_OVARY_Human0.93615089
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91714852
39* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90812583
40ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90204706
41ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88630283
42ESR1_20079471_ChIP-ChIP_T-47D_Human0.88534562
43* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88143762
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87759066
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87679419
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86381069
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85343002
48TCF4_18268006_ChIP-ChIP_LS174T_Human0.84640872
49* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84412740
50* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84412740
51TP53_16413492_ChIP-PET_HCT116_Human0.82223666
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80432531
53AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80085024
54* GATA4_25053715_ChIP-Seq_YYC3_Human0.78736452
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78291964
56IRF8_22096565_ChIP-ChIP_GC-B_Human0.77966337
57AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77510680
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74243559
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73654359
60* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.73236533
61HNFA_21074721_ChIP-Seq_CACO-2_Human0.72198215
62PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71902594
63SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71279805
64* EZH2_27294783_Chip-Seq_NPCs_Mouse0.70351654
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.69951710
66* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69683199
67ESR1_21235772_ChIP-Seq_MCF-7_Human0.69490605
68GATA6_25053715_ChIP-Seq_YYC3_Human0.69422246
69NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68703729
70KAP1_22055183_ChIP-Seq_ESCs_Mouse0.68403749
71SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67423030
72* NFE2_27457419_Chip-Seq_LIVER_Mouse0.66927884
73SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66821590
74TP63_23658742_ChIP-Seq_EP156T_Human0.66768928
75FOXO3_23340844_ChIP-Seq_DLD1_Human0.66068381
76NFYA_21822215_ChIP-Seq_K562_Human0.65030873
77RARA_24833708_ChIP-Seq_LIVER_Mouse0.64564014
78CTNNB1_20460455_ChIP-Seq_HCT116_Human0.64066212
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62836652
80CDX2_20551321_ChIP-Seq_CACO-2_Human0.62752439
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.62697473
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62674569
83* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60908339
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60340543
85PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59020023
86NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58818213
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.58218515
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57894514
89PHF8_20622853_ChIP-Seq_HELA_Human0.57787131
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56920475
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.55821681
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.55821681
93RARB_24833708_ChIP-Seq_LIVER_Mouse0.55704424
94ESET_19884257_ChIP-Seq_ESCs_Mouse0.55546783
95* CEBPB_22108803_ChIP-Seq_LS180_Human0.55528052
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55196314
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.55193041
98* BCAT_22108803_ChIP-Seq_LS180_Human0.54760406
99* CRX_20693478_ChIP-Seq_RETINA_Mouse0.54633815
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.54405349
101* TBX20_22328084_ChIP-Seq_HEART_Mouse0.53615134
102* TBX20_22080862_ChIP-Seq_HEART_Mouse0.53615134
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.53599582
104AR_20517297_ChIP-Seq_VCAP_Human0.53074662
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53053593
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.52766303
107* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.52533165
108FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52082909
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.51161078
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.51020522
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.50776372
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50521369
113BP1_19119308_ChIP-ChIP_Hs578T_Human0.47705990
114CBP_21632823_ChIP-Seq_H3396_Human0.47277237
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.47275487
116STAT1_17558387_ChIP-Seq_HELA_Human0.45739311
117ZNF263_19887448_ChIP-Seq_K562_Human0.45165461
118GATA3_24758297_ChIP-Seq_MCF-7_Human0.45156150
119MYC_19915707_ChIP-ChIP_AK7_Human0.44140309
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43232787
121GATA2_19941826_ChIP-Seq_K562_Human0.42399639
122IRF1_19129219_ChIP-ChIP_H3396_Human0.41874181
123CDX2_22108803_ChIP-Seq_LS180_Human0.41349932
124LXR_22292898_ChIP-Seq_THP-1_Human0.41207822
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.41143654
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40950945
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40376727
128* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40066294
129SOX2_20726797_ChIP-Seq_SW620_Human0.39880555
130CSB_26484114_Chip-Seq_FIBROBLAST_Human0.39855891
131FOXH1_21741376_ChIP-Seq_EPCs_Human0.39671643
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39196133
133GATA1_19941826_ChIP-Seq_K562_Human0.39105289
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.39093388
135EGR1_19032775_ChIP-ChIP_M12_Human0.39020301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.02467756
2MP0005360_urolithiasis6.91284897
3MP0005085_abnormal_gallbladder_physiolo6.09233753
4MP0005365_abnormal_bile_salt6.08145912
5MP0008875_abnormal_xenobiotic_pharmacok4.62811110
6MP0003806_abnormal_nucleotide_metabolis4.10260684
7MP0003252_abnormal_bile_duct3.91911284
8MP0010329_abnormal_lipoprotein_level3.74323041
9MP0009840_abnormal_foam_cell2.82539574
10MP0005083_abnormal_biliary_tract2.80889419
11MP0005332_abnormal_amino_acid2.60952733
12MP0003195_calcinosis2.57568783
13MP0001666_abnormal_nutrient_absorption2.36910543
14MP0003191_abnormal_cellular_cholesterol2.36802635
15MP0002118_abnormal_lipid_homeostasis2.28228143
16MP0000609_abnormal_liver_physiology2.21004659
17MP0005670_abnormal_white_adipose2.09212353
18MP0005319_abnormal_enzyme/_coenzyme1.88893723
19MP0004019_abnormal_vitamin_homeostasis1.88619050
20MP0002138_abnormal_hepatobiliary_system1.75428065
21MP0003868_abnormal_feces_composition1.72624951
22MP0001764_abnormal_homeostasis1.55879140
23MP0005584_abnormal_enzyme/coenzyme_acti1.55832245
24MP0004130_abnormal_muscle_cell1.53762836
25MP0009697_abnormal_copulation1.53034148
26MP0003011_delayed_dark_adaptation1.50808945
27MP0002254_reproductive_system_inflammat1.41258036
28MP0004272_abnormal_basement_membrane1.40871955
29MP0003186_abnormal_redox_activity1.34336397
30MP0002837_dystrophic_cardiac_calcinosis1.33002414
31MP0003705_abnormal_hypodermis_morpholog1.31182294
32MP0005647_abnormal_sex_gland1.29516094
33MP0005666_abnormal_adipose_tissue1.23714338
34MP0002876_abnormal_thyroid_physiology1.20751454
35MP0005023_abnormal_wound_healing1.20329772
36MP0002971_abnormal_brown_adipose1.19605973
37MP0009643_abnormal_urine_homeostasis1.19152426
38MP0001915_intracranial_hemorrhage1.10578141
39MP0000598_abnormal_liver_morphology1.09569199
40MP0009764_decreased_sensitivity_to1.07773914
41MP0005334_abnormal_fat_pad1.05131161
42MP0010368_abnormal_lymphatic_system1.02197566
43MP0005451_abnormal_body_composition1.01327206
44MP0006036_abnormal_mitochondrial_physio1.01122620
45MP0008004_abnormal_stomach_pH0.99567658
46MP0002909_abnormal_adrenal_gland0.98790987
47MP0009763_increased_sensitivity_to0.98666676
48MP0003656_abnormal_erythrocyte_physiolo0.96341321
49MP0002078_abnormal_glucose_homeostasis0.96173280
50MP0001661_extended_life_span0.92049608
51MP0005535_abnormal_body_temperature0.91367991
52MP0003690_abnormal_glial_cell0.85691240
53MP0009780_abnormal_chondrocyte_physiolo0.84183903
54MP0009642_abnormal_blood_homeostasis0.82515055
55MP0003566_abnormal_cell_adhesion0.81184374
56MP0005376_homeostasis/metabolism_phenot0.81109888
57MP0008469_abnormal_protein_level0.79277717
58MP0000604_amyloidosis0.78513949
59MP0009115_abnormal_fat_cell0.78258834
60MP0005636_abnormal_mineral_homeostasis0.77382527
61MP0005266_abnormal_metabolism0.76830122
62MP0004185_abnormal_adipocyte_glucose0.75226284
63MP0006035_abnormal_mitochondrial_morpho0.75106103
64MP0003950_abnormal_plasma_membrane0.74671425
65MP0003879_abnormal_hair_cell0.73875559
66MP0005448_abnormal_energy_balance0.73583351
67MP0009765_abnormal_xenobiotic_induced0.69273348
68MP0005375_adipose_tissue_phenotype0.67752823
69MP0002132_abnormal_respiratory_system0.66965648
70MP0005084_abnormal_gallbladder_morpholo0.65563667
71MP0002970_abnormal_white_adipose0.64257396
72MP0004782_abnormal_surfactant_physiolog0.63297553
73MP0005220_abnormal_exocrine_pancreas0.60173796
74MP0008438_abnormal_cutaneous_collagen0.60115594
75MP0002282_abnormal_trachea_morphology0.59372418
76MP0005464_abnormal_platelet_physiology0.58748440
77MP0003724_increased_susceptibility_to0.58535508
78MP0004381_abnormal_hair_follicle0.58407050
79MP0005408_hypopigmentation0.57721681
80MP0001756_abnormal_urination0.57559430
81MP0005187_abnormal_penis_morphology0.55867961
82MP0002928_abnormal_bile_duct0.54143133
83MP0005257_abnormal_intraocular_pressure0.53321566
84MP0003953_abnormal_hormone_level0.49681679
85MP0002168_other_aberrant_phenotype0.48535768
86MP0000639_abnormal_adrenal_gland0.47977786
87MP0003279_aneurysm0.47760534
88MP0002128_abnormal_blood_circulation0.46634036
89MP0002269_muscular_atrophy0.46481756
90MP0003941_abnormal_skin_development0.46286096
91MP0002332_abnormal_exercise_endurance0.45676750
92MP0005058_abnormal_lysosome_morphology0.44200457
93MP0005395_other_phenotype0.44024507
94MP0005248_abnormal_Harderian_gland0.43508190
95MP0003959_abnormal_lean_body0.42972350
96MP0008874_decreased_physiological_sensi0.42220137
97MP0003638_abnormal_response/metabolism_0.42204677
98MP0009384_cardiac_valve_regurgitation0.41856099
99MP0005330_cardiomyopathy0.41382415
100MP0003300_gastrointestinal_ulcer0.40686054
101MP0000230_abnormal_systemic_arterial0.39584070
102MP0000579_abnormal_nail_morphology0.38899234
103MP0002136_abnormal_kidney_physiology0.38857604
104MP0002796_impaired_skin_barrier0.38506278
105MP0002060_abnormal_skin_morphology0.38417011
106MP0001881_abnormal_mammary_gland0.38152997
107MP0000249_abnormal_blood_vessel0.37906686
108MP0003091_abnormal_cell_migration0.37785812
109MP0002249_abnormal_larynx_morphology0.37606575
110MP0005275_abnormal_skin_tensile0.37348778
111MP0002896_abnormal_bone_mineralization0.36235668
112MP0005503_abnormal_tendon_morphology0.36218464
113MP0003329_amyloid_beta_deposits0.36081372
114MP0001958_emphysema0.36008286
115MP0005452_abnormal_adipose_tissue0.35999640
116MP0000467_abnormal_esophagus_morphology0.35488234
117MP0000427_abnormal_hair_cycle0.33830225
118MP0003646_muscle_fatigue0.32807018
119MP0005164_abnormal_response_to0.31891265
120MP0002295_abnormal_pulmonary_circulatio0.31263147
121MP0004883_abnormal_blood_vessel0.30854727
122MP0003075_altered_response_to0.30550683
123MP0005595_abnormal_vascular_smooth0.30550309
124MP0009053_abnormal_anal_canal0.30298253
125MP0009672_abnormal_birth_weight0.29806569
126MP0005075_abnormal_melanosome_morpholog0.29125237

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.07757816
2Deep venous thrombosis (HP:0002625)6.84271647
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.63483256
4Prolonged partial thromboplastin time (HP:0003645)6.15633758
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.03491995
6Xanthomatosis (HP:0000991)5.99161402
7Complement deficiency (HP:0004431)5.90686716
8Hypobetalipoproteinemia (HP:0003563)5.68308116
9Hyperlipoproteinemia (HP:0010980)5.28216713
10Hyperammonemia (HP:0001987)4.64331604
11Hypolipoproteinemia (HP:0010981)4.61506884
12Hyperglycinemia (HP:0002154)4.60565316
13Epidermoid cyst (HP:0200040)4.59547260
14Joint hemorrhage (HP:0005261)4.58434496
15Hyperglycinuria (HP:0003108)4.54001708
16Nephritis (HP:0000123)4.43397290
17Ketosis (HP:0001946)4.39459092
18Hypoglycemic coma (HP:0001325)4.36138801
19Hypoalphalipoproteinemia (HP:0003233)4.36021636
20Abnormality of serine family amino acid metabolism (HP:0010894)4.30931777
21Abnormality of glycine metabolism (HP:0010895)4.30931777
22Abnormality of complement system (HP:0005339)4.28775915
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27915869
24Abnormality of the common coagulation pathway (HP:0010990)4.10996860
25Fat malabsorption (HP:0002630)3.95588854
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.84536789
27Abnormality of the intrinsic pathway (HP:0010989)3.82871291
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.78516674
29Abnormality of methionine metabolism (HP:0010901)3.76326887
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.68698901
31Abnormality of fatty-acid metabolism (HP:0004359)3.63865959
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.52382411
33Conjugated hyperbilirubinemia (HP:0002908)3.52044875
34Hypercholesterolemia (HP:0003124)3.51434378
35Ketoacidosis (HP:0001993)3.42689115
36Myocardial infarction (HP:0001658)3.20525037
37Abnormality of pyrimidine metabolism (HP:0004353)3.19346504
38Hypochromic microcytic anemia (HP:0004840)3.15896672
39Skin nodule (HP:0200036)3.13578198
40Abnormality of serum amino acid levels (HP:0003112)3.10526622
41Hyperbilirubinemia (HP:0002904)3.07333740
42Steatorrhea (HP:0002570)2.99284564
43Dicarboxylic aciduria (HP:0003215)2.92949833
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92949833
45Delayed CNS myelination (HP:0002188)2.86284126
46Abnormality of nucleobase metabolism (HP:0010932)2.85844903
47Metabolic acidosis (HP:0001942)2.82815245
48Systemic lupus erythematosus (HP:0002725)2.76328415
49Hepatocellular carcinoma (HP:0001402)2.74632126
50Hypoglycemic seizures (HP:0002173)2.74479819
51Abnormality of purine metabolism (HP:0004352)2.69094102
52Hyperinsulinemic hypoglycemia (HP:0000825)2.68427152
53Lethargy (HP:0001254)2.60468601
54Spontaneous abortion (HP:0005268)2.49680942
55Recurrent gram-negative bacterial infections (HP:0005420)2.46730069
56Abnormal gallbladder morphology (HP:0012437)2.45978202
57Cholelithiasis (HP:0001081)2.40815855
58Osteomalacia (HP:0002749)2.40438951
59Vascular calcification (HP:0004934)2.37959912
60Cerebral edema (HP:0002181)2.34557038
61Renal cortical cysts (HP:0000803)2.33085387
62Gout (HP:0001997)2.30579741
63Mitral stenosis (HP:0001718)2.29404427
64Hemorrhage of the eye (HP:0011885)2.27172181
65Amyloidosis (HP:0011034)2.23377858
66Pancreatitis (HP:0001733)2.21823170
67Neonatal onset (HP:0003623)2.20720724
68Sensorimotor neuropathy (HP:0007141)2.20478817
69Malnutrition (HP:0004395)2.17862462
70Cardiovascular calcification (HP:0011915)2.17356160
71Generalized aminoaciduria (HP:0002909)2.16739094
72Abnormal delivery (HP:0001787)2.15501096
73Purpura (HP:0000979)2.14181102
74Spastic diplegia (HP:0001264)2.13376925
75Vomiting (HP:0002013)2.13167515
76Abnormal cartilage morphology (HP:0002763)2.12497311
77Cholecystitis (HP:0001082)2.12051488
78Abnormal gallbladder physiology (HP:0012438)2.12051488
79Acanthocytosis (HP:0001927)2.11903896
80Irritability (HP:0000737)2.11728822
81Hyperglycemia (HP:0003074)2.11698179
82Enlarged kidneys (HP:0000105)2.10793582
83Esophageal varix (HP:0002040)2.09606549
84Myoglobinuria (HP:0002913)2.08618113
85Hypertriglyceridemia (HP:0002155)2.08054241
86Glomerulonephritis (HP:0000099)2.07915290
87Abnormality of proline metabolism (HP:0010907)2.07860631
88Hydroxyprolinuria (HP:0003080)2.07860631
89Late onset (HP:0003584)2.07401127
90Brushfield spots (HP:0001088)2.03175211
91Protrusio acetabuli (HP:0003179)1.99027005
92Abnormality of the gallbladder (HP:0005264)1.95155931
93Pulmonary embolism (HP:0002204)1.94561397
94Joint swelling (HP:0001386)1.93932185
95Gingival bleeding (HP:0000225)1.93271892
96Elevated alkaline phosphatase (HP:0003155)1.92213144
97Neonatal hypoglycemia (HP:0001998)1.91751393
98Opisthotonus (HP:0002179)1.85766921
99Elevated hepatic transaminases (HP:0002910)1.85377110
100Menorrhagia (HP:0000132)1.85115497
101Abnormality of the Achilles tendon (HP:0005109)1.84947697
102Bile duct proliferation (HP:0001408)1.80910272
103Abnormal biliary tract physiology (HP:0012439)1.80910272
104Symptomatic seizures (HP:0011145)1.80522807
105Abnormality of iron homeostasis (HP:0011031)1.79845035
106Rickets (HP:0002748)1.79632589
107Proximal tubulopathy (HP:0000114)1.77708870
108Reduced antithrombin III activity (HP:0001976)1.77495519
109Arthropathy (HP:0003040)1.76805076
110Increased mean platelet volume (HP:0011877)1.76740565
111Abnormality of vitamin metabolism (HP:0100508)1.76257274
112Abnormality of transition element cation homeostasis (HP:0011030)1.75410437
113Thrombophlebitis (HP:0004418)1.74413936
114Abnormal enzyme/coenzyme activity (HP:0012379)1.74406057
115Fair hair (HP:0002286)1.73483981
116Wrist flexion contracture (HP:0001239)1.72565296
117Decreased circulating renin level (HP:0003351)1.69901072
118Hyperphosphaturia (HP:0003109)1.69786353
119Abnormality of alkaline phosphatase activity (HP:0004379)1.69683474
120Atrioventricular block (HP:0001678)1.68751798
121Enlarged penis (HP:0000040)1.67928401
122Bifid scrotum (HP:0000048)1.57861457
123Glycosuria (HP:0003076)1.55175308
124Abnormality of urine glucose concentration (HP:0011016)1.55175308
125Back pain (HP:0003418)1.53111251
126Abnormal platelet volume (HP:0011876)1.52419158
127Abnormality of carpal bone ossification (HP:0006257)1.49369815
128Premature rupture of membranes (HP:0001788)1.48314640
129Hypophosphatemic rickets (HP:0004912)1.46907233
130Epistaxis (HP:0000421)1.46726221
131Periodontitis (HP:0000704)1.44930088
132Alkalosis (HP:0001948)1.43830511
133Abnormal tarsal ossification (HP:0008369)1.42890541
134Aortic aneurysm (HP:0004942)1.38201302
135Vertebral compression fractures (HP:0002953)1.37014780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.09393795
2SIK14.60632867
3ERN14.16907498
4FGFR43.75338750
5INSRR3.58116498
6DDR22.67855099
7TAOK32.38094794
8ERBB42.36116590
9TRIB32.19624385
10MAP2K42.01053979
11CAMK1D1.99287716
12MST1R1.88926737
13ICK1.84559322
14LATS11.83730961
15PIK3CG1.83624935
16SCYL21.60559946
17FLT31.60333207
18TIE11.55813932
19MAPK111.55741278
20PINK11.52178733
21NEK91.51884616
22MELK1.50362914
23PRKAA21.47793682
24OBSCN1.43645480
25FRK1.42184925
26PRPF4B1.40530632
27PKN21.38038214
28FGFR21.35413894
29MAP3K71.34405532
30CAMK1G1.31580769
31NLK1.25949140
32PAK21.25315746
33TRPM71.24838494
34IRAK31.24004851
35TGFBR21.23419429
36FGFR31.22157006
37NTRK11.20389830
38JAK11.16067114
39TYK21.15787964
40FER1.12027878
41GRK11.11436488
42RIPK11.10191415
43PDK41.09050751
44PDK31.09050751
45JAK21.02938798
46STK38L1.01552458
47PDGFRB1.00944264
48MAP2K30.98159385
49PTK60.97772212
50STK380.97267720
51ABL20.95625483
52DAPK20.92938429
53MAPK120.92378946
54PRKAA10.92343505
55MAPK70.90630390
56MAP3K20.90164399
57GRK60.86367930
58EPHA30.82063696
59ERBB20.79914942
60MAP3K120.79666306
61CSF1R0.77578196
62MOS0.76807675
63TTN0.76378548
64PRKACG0.75563415
65MET0.73248739
66LMTK20.72898742
67SGK30.72744952
68PHKG20.72728655
69PHKG10.72728655
70KDR0.71105844
71MAP3K140.70861509
72MAPK150.69557273
73MAPK40.69280169
74MAP3K30.68119935
75EPHB10.66377076
76CSK0.66233513
77KSR20.65117917
78PDK20.64615345
79CDC42BPA0.64370458
80GSK3A0.64053858
81ZAP700.63883912
82EEF2K0.63697493
83CDK60.63342985
84PRKCZ0.62583878
85PIK3CA0.61745116
86CAMK2G0.61061932
87PDGFRA0.60888134
88CAMKK20.60574385
89GRK50.60215641
90AKT20.59440135
91SGK20.59203800
92TBK10.59080243
93IGF1R0.58167903
94CAMK40.57715371
95MAP2K60.54895605
96PRKCH0.52945822
97NTRK30.52452635
98PKN10.51876819
99PRKG10.51048515
100PAK40.50817491
101PDPK10.50274997
102MAP3K10.49711726
103MAPKAPK30.49599653
104ARAF0.47644152
105MAP3K60.47394086
106IRAK10.45862396
107MTOR0.45597835
108MAP2K10.45486909
109DYRK1B0.43861007
110LATS20.43542430
111AKT30.43008711
112MAP3K130.41477687
113ADRBK20.40642472
114PRKACA0.40524994
115PTK20.40248861
116CDK120.40221247
117IRAK20.39511406
118GRK70.38330415
119PRKCG0.37697569
120PRKG20.36998103
121MYLK0.36468796
122EPHB20.35490411
123PDK10.33206996
124TAOK20.32946217
125SGK4940.32922356
126SGK2230.32922356
127PRKCQ0.32714391
128SRC0.32622798
129ZAK0.32612209
130PRKD20.31746497
131PRKD10.29733121
132SGK10.29420011
133MAP3K50.29395391
134RPS6KA30.29085404
135EIF2AK20.28394694
136RET0.28119557

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45887049
2Nitrogen metabolism_Homo sapiens_hsa009103.30829411
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04739823
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97600124
5Arginine biosynthesis_Homo sapiens_hsa002202.84290871
6Fatty acid degradation_Homo sapiens_hsa000712.81682112
7Complement and coagulation cascades_Homo sapiens_hsa046102.72378177
8* Tryptophan metabolism_Homo sapiens_hsa003802.69187103
9* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63908211
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63192090
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57283679
12Propanoate metabolism_Homo sapiens_hsa006402.38765938
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34134713
14PPAR signaling pathway_Homo sapiens_hsa033202.25585049
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20230701
16Butanoate metabolism_Homo sapiens_hsa006502.20077565
17Peroxisome_Homo sapiens_hsa041462.17820726
18Fatty acid metabolism_Homo sapiens_hsa012122.15006305
19* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00527535
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.99572279
21Chemical carcinogenesis_Homo sapiens_hsa052041.94233725
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.87584575
23beta-Alanine metabolism_Homo sapiens_hsa004101.86919496
24Histidine metabolism_Homo sapiens_hsa003401.80020915
25Caffeine metabolism_Homo sapiens_hsa002321.73838919
26Staphylococcus aureus infection_Homo sapiens_hsa051501.69893968
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69762545
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66141635
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.60882821
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58839932
31* Retinol metabolism_Homo sapiens_hsa008301.56514024
32Phenylalanine metabolism_Homo sapiens_hsa003601.55018029
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50763934
34Pyruvate metabolism_Homo sapiens_hsa006201.50672495
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47778365
36Fatty acid elongation_Homo sapiens_hsa000621.44531337
37Bile secretion_Homo sapiens_hsa049761.44301843
38Selenocompound metabolism_Homo sapiens_hsa004501.42716602
39Starch and sucrose metabolism_Homo sapiens_hsa005001.39205138
40* Tyrosine metabolism_Homo sapiens_hsa003501.33911171
41ABC transporters_Homo sapiens_hsa020101.32835583
42Sulfur metabolism_Homo sapiens_hsa009201.26640140
43Carbon metabolism_Homo sapiens_hsa012001.25582588
44Fat digestion and absorption_Homo sapiens_hsa049751.21007581
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.07151586
46Biosynthesis of amino acids_Homo sapiens_hsa012301.06834428
47Fatty acid biosynthesis_Homo sapiens_hsa000611.05738742
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04385082
49Folate biosynthesis_Homo sapiens_hsa007901.03968057
50Steroid biosynthesis_Homo sapiens_hsa001000.96890142
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.96306253
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92706367
53Lysine degradation_Homo sapiens_hsa003100.88659042
54Glycerolipid metabolism_Homo sapiens_hsa005610.87970750
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86936686
56Arginine and proline metabolism_Homo sapiens_hsa003300.84756525
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83467660
58Sulfur relay system_Homo sapiens_hsa041220.82892272
59Vitamin digestion and absorption_Homo sapiens_hsa049770.77358232
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72187836
61* Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69753134
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.64582850
63Glutathione metabolism_Homo sapiens_hsa004800.62675225
64Pertussis_Homo sapiens_hsa051330.56249679
65One carbon pool by folate_Homo sapiens_hsa006700.56092441
66Pentose phosphate pathway_Homo sapiens_hsa000300.53919427
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.47406369
68* Metabolic pathways_Homo sapiens_hsa011000.46066305
69Prion diseases_Homo sapiens_hsa050200.44322501
70Insulin resistance_Homo sapiens_hsa049310.41880349
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38515046
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38409619
73Fructose and mannose metabolism_Homo sapiens_hsa000510.36067676
74Galactose metabolism_Homo sapiens_hsa000520.35034023
75Linoleic acid metabolism_Homo sapiens_hsa005910.29268823
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.26455858
77AMPK signaling pathway_Homo sapiens_hsa041520.25059233
78Glucagon signaling pathway_Homo sapiens_hsa049220.24065666
79ECM-receptor interaction_Homo sapiens_hsa045120.21855836
80Systemic lupus erythematosus_Homo sapiens_hsa053220.17562919
81Renin-angiotensin system_Homo sapiens_hsa046140.13185167
82Other glycan degradation_Homo sapiens_hsa005110.12657787
83Ovarian steroidogenesis_Homo sapiens_hsa049130.09551514
84Insulin signaling pathway_Homo sapiens_hsa049100.07742916
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.05483368
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02620598
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02193470
88Arachidonic acid metabolism_Homo sapiens_hsa005900.01650223
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01544140
90Mineral absorption_Homo sapiens_hsa049780.00938236
91Protein digestion and absorption_Homo sapiens_hsa04974-0.2144531
92Circadian rhythm_Homo sapiens_hsa04710-0.2098655
93Ether lipid metabolism_Homo sapiens_hsa00565-0.2086074
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2043198
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.1688907
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1674238
97Amoebiasis_Homo sapiens_hsa05146-0.1615454
98PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.1555658
99African trypanosomiasis_Homo sapiens_hsa05143-0.1548822
100N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1545723
101Hepatitis C_Homo sapiens_hsa05160-0.1544542
102Prolactin signaling pathway_Homo sapiens_hsa04917-0.1376606
103Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1336977
104Sphingolipid metabolism_Homo sapiens_hsa00600-0.1238168
105Pancreatic secretion_Homo sapiens_hsa04972-0.0894630
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0859265
107Regulation of autophagy_Homo sapiens_hsa04140-0.0780148
108Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0725142
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0697347
110Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0607897
111Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0580258
112* Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0558995
113Focal adhesion_Homo sapiens_hsa04510-0.0272859
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0178700
115Serotonergic synapse_Homo sapiens_hsa04726-0.0016474

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