ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fucose catabolic process (GO:0019317)	5.11526818
2	L-fucose metabolic process (GO:0042354)	5.11526818
3	L-fucose catabolic process (GO:0042355)	5.11526818
4	DNA deamination (GO:0045006)	4.23857624
5	cell wall macromolecule metabolic process (GO:0044036)	4.10883812
6	negative regulation of thymocyte apoptotic process (GO:0070244)	3.96043140
7	tryptophan catabolic process (GO:0006569)	3.88663001
8	indole-containing compound catabolic process (GO:0042436)	3.88663001
9	indolalkylamine catabolic process (GO:0046218)	3.88663001
10	tryptophan metabolic process (GO:0006568)	3.67647034
11	positive regulation of granulocyte differentiation (GO:0030854)	3.66078472
12	indolalkylamine metabolic process (GO:0006586)	3.65645309
13	seminiferous tubule development (GO:0072520)	3.65015489
14	cilium or flagellum-dependent cell motility (GO:0001539)	3.47292628
15	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.46315586
16	mannosylation (GO:0097502)	3.45248452
17	axoneme assembly (GO:0035082)	3.39999024
18	detection of light stimulus involved in sensory perception (GO:0050962)	3.39976875
19	detection of light stimulus involved in visual perception (GO:0050908)	3.39976875
20	piRNA metabolic process (GO:0034587)	3.38461379
21	negative regulation of growth of symbiont in host (GO:0044130)	3.33206424
22	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	3.33206424
23	modulation of growth of symbiont involved in interaction with host (GO:0044144)	3.33206424
24	regulation of growth of symbiont in host (GO:0044126)	3.33206424
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.30312126
26	NADH dehydrogenase complex assembly (GO:0010257)	3.30312126
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.30312126
28	respiratory chain complex IV assembly (GO:0008535)	3.29511692
29	cell wall macromolecule catabolic process (GO:0016998)	3.23989252
30	protein complex biogenesis (GO:0070271)	3.23756200
31	amine catabolic process (GO:0009310)	3.23255049
32	cellular biogenic amine catabolic process (GO:0042402)	3.23255049
33	positive regulation of B cell differentiation (GO:0045579)	3.20370848
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.17590587
35	positive regulation of defense response to virus by host (GO:0002230)	3.08731116
36	cytochrome complex assembly (GO:0017004)	3.07642484
37	mast cell degranulation (GO:0043303)	3.04376740
38	mast cell activation involved in immune response (GO:0002279)	3.04376740
39	neutrophil mediated immunity (GO:0002446)	3.01267695
40	adenosine metabolic process (GO:0046085)	3.00101153
41	rRNA catabolic process (GO:0016075)	2.98731711
42	protein polyglutamylation (GO:0018095)	2.95101855
43	positive regulation of prostaglandin secretion (GO:0032308)	2.92387271
44	prenylation (GO:0097354)	2.92063759
45	protein prenylation (GO:0018342)	2.92063759
46	negative regulation of telomere maintenance (GO:0032205)	2.91917984
47	preassembly of GPI anchor in ER membrane (GO:0016254)	2.89873906
48	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86997452
49	DNA methylation involved in gamete generation (GO:0043046)	2.85447752
50	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.83574142
51	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.83574142
52	photoreceptor cell maintenance (GO:0045494)	2.81076494
53	behavioral response to nicotine (GO:0035095)	2.76566713
54	neural tube formation (GO:0001841)	2.76340390
55	ubiquinone biosynthetic process (GO:0006744)	2.76326641
56	cellular response to exogenous dsRNA (GO:0071360)	2.74011695
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73339409
58	amino acid salvage (GO:0043102)	2.72162339
59	L-methionine salvage (GO:0071267)	2.72162339
60	L-methionine biosynthetic process (GO:0071265)	2.72162339
61	regulation of female gonad development (GO:2000194)	2.71287081
62	kynurenine metabolic process (GO:0070189)	2.70212616
63	DNA double-strand break processing (GO:0000729)	2.69497785
64	negative regulation of phagocytosis (GO:0050765)	2.68937409
65	positive regulation of fatty acid transport (GO:2000193)	2.68635427
66	regulation of thymocyte apoptotic process (GO:0070243)	2.68484699
67	epithelial cilium movement (GO:0003351)	2.66036521
68	positive regulation of icosanoid secretion (GO:0032305)	2.62000249
69	negative regulation of B cell apoptotic process (GO:0002903)	2.60876521
70	sperm motility (GO:0030317)	2.60405366
71	platelet dense granule organization (GO:0060155)	2.60351414
72	Peyers patch development (GO:0048541)	2.59908149
73	mucosal-associated lymphoid tissue development (GO:0048537)	2.59908149
74	killing of cells of other organism (GO:0031640)	2.59246642
75	disruption of cells of other organism (GO:0044364)	2.59246642
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.57878413
77	mast cell activation (GO:0045576)	2.55814585
78	replication fork processing (GO:0031297)	2.54895814
79	cardiolipin metabolic process (GO:0032048)	2.54603072
80	regulation of B cell apoptotic process (GO:0002902)	2.53515404
81	protein K11-linked deubiquitination (GO:0035871)	2.50686521
82	aromatic amino acid family catabolic process (GO:0009074)	2.50533325
83	reactive oxygen species biosynthetic process (GO:1903409)	2.50003306
84	peptidyl-histidine modification (GO:0018202)	2.49819184
85	DNA integration (GO:0015074)	2.49324947
86	regulation of granulocyte differentiation (GO:0030852)	2.48726907
87	DNA dealkylation (GO:0035510)	2.47754972
88	response to hydroperoxide (GO:0033194)	2.47638944
89	cellular response to ethanol (GO:0071361)	2.46763172
90	response to pheromone (GO:0019236)	2.46692722
91	centriole replication (GO:0007099)	2.46245775
92	DNA modification (GO:0006304)	2.45751397
93	regulation of telomere maintenance (GO:0032204)	2.45362410
94	purine deoxyribonucleotide catabolic process (GO:0009155)	2.45106598
95	cellular ketone body metabolic process (GO:0046950)	2.44865406
96	GPI anchor metabolic process (GO:0006505)	2.42925853
97	regulation of hexokinase activity (GO:1903299)	2.42685725
98	regulation of glucokinase activity (GO:0033131)	2.42685725
99	negative regulation of mast cell activation (GO:0033004)	2.40753891
100	myeloid leukocyte mediated immunity (GO:0002444)	2.39237041

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75123065
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.58028390
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20463975
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.85554567
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66875212
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.62905742
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.33838730
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28976987
9	VDR_22108803_ChIP-Seq_LS180_Human	2.26925113
10	EWS_26573619_Chip-Seq_HEK293_Human	2.26899205
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14634658
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09794996
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02817253
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.90974125
15	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.89464774
16	FUS_26573619_Chip-Seq_HEK293_Human	1.89369718
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.84294703
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83627718
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.81634894
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.81634894
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79793262
22	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.78981116
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78300504
24	P300_19829295_ChIP-Seq_ESCs_Human	1.77477273
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.75951169
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68198412
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.66972637
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60607873
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58735413
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.58434556
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56349764
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.53684358
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53166406
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47818061
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.44826240
36	SOX2_19829295_ChIP-Seq_ESCs_Human	1.43996873
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.43996873
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40430676
39	GATA3_26560356_Chip-Seq_TH2_Human	1.40127880
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38050057
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.37999111
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37474429
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36666239
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36666239
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36600192
46	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.36013831
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.35690225
48	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.32525967
49	MYC_18940864_ChIP-ChIP_HL60_Human	1.31546268
50	STAT3_23295773_ChIP-Seq_U87_Human	1.30933529
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29072334
52	TCF4_23295773_ChIP-Seq_U87_Human	1.28739380
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28059476
54	NCOR_22424771_ChIP-Seq_293T_Human	1.27741625
55	AR_20517297_ChIP-Seq_VCAP_Human	1.26172809
56	MYB_26560356_Chip-Seq_TH2_Human	1.26041757
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25267470
58	TCF4_22108803_ChIP-Seq_LS180_Human	1.23579756
59	AR_25329375_ChIP-Seq_VCAP_Human	1.23186513
60	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22734019
61	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22147716
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22009252
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.21919789
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20828746
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20828746
66	GATA3_27048872_Chip-Seq_THYMUS_Human	1.20499893
67	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.20186441
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18228182
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.17445344
70	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15587982
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14334756
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13795256
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.13344920
74	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.12187611
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11202166
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10182507
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10133469
78	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07863956
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07424570
80	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.07418640
81	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04607697
82	SCL_19346495_ChIP-Seq_HPC-7_Human	1.04065660
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03326240
84	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02180815
85	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00911035
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00113622
87	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99680645
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99435245
89	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98467675
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.97917258
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97730887
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96932946
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96454365
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95429457
95	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.93736197
96	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.93265128
97	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.92835908
98	ELK1_19687146_ChIP-ChIP_HELA_Human	0.92285759
99	SMRT_27268052_Chip-Seq_Bcells_Human	0.91754920
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.91492587

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009278_abnormal_bone_marrow	3.14178694
2	MP0008877_abnormal_DNA_methylation	2.90794995
3	MP0002876_abnormal_thyroid_physiology	2.65382773
4	MP0001986_abnormal_taste_sensitivity	2.46302900
5	MP0003787_abnormal_imprinting	2.33559618
6	MP0005075_abnormal_melanosome_morpholog	2.29546681
7	MP0008057_abnormal_DNA_replication	2.28897330
8	MP0005397_hematopoietic_system_phenotyp	2.25278746
9	MP0001545_abnormal_hematopoietic_system	2.25278746
10	MP0008872_abnormal_physiological_respon	2.13568134
11	MP0001968_abnormal_touch/_nociception	2.12611690
12	MP0000569_abnormal_digit_pigmentation	2.09026796
13	MP0000372_irregular_coat_pigmentation	2.04499140
14	MP0005671_abnormal_response_to	2.02285206
15	MP0008875_abnormal_xenobiotic_pharmacok	2.01147982
16	MP0006072_abnormal_retinal_apoptosis	1.99953164
17	MP0003195_calcinosis	1.94951717
18	MP0005645_abnormal_hypothalamus_physiol	1.88171408
19	MP0005551_abnormal_eye_electrophysiolog	1.85197249
20	MP0008058_abnormal_DNA_repair	1.78695015
21	MP0005646_abnormal_pituitary_gland	1.73223353
22	MP0001835_abnormal_antigen_presentation	1.73071730
23	MP0005410_abnormal_fertilization	1.71751350
24	MP0004147_increased_porphyrin_level	1.66846478
25	MP0003252_abnormal_bile_duct	1.56975529
26	MP0002736_abnormal_nociception_after	1.56504369
27	MP0003718_maternal_effect	1.54546750
28	MP0001764_abnormal_homeostasis	1.47854863
29	MP0009785_altered_susceptibility_to	1.46371760
30	MP0001501_abnormal_sleep_pattern	1.44245569
31	MP0005174_abnormal_tail_pigmentation	1.42879756
32	MP0002132_abnormal_respiratory_system	1.42181564
33	MP0002160_abnormal_reproductive_system	1.41216076
34	MP0002396_abnormal_hematopoietic_system	1.41023598
35	MP0001800_abnormal_humoral_immune	1.40225801
36	MP0003763_abnormal_thymus_physiology	1.39355161
37	MP0002837_dystrophic_cardiac_calcinosis	1.38679449
38	MP0003646_muscle_fatigue	1.37229987
39	MP0006292_abnormal_olfactory_placode	1.36552796
40	MP0002148_abnormal_hypersensitivity_rea	1.35461818
41	MP0002095_abnormal_skin_pigmentation	1.34436102
42	MP0010094_abnormal_chromosome_stability	1.33907098
43	MP0002138_abnormal_hepatobiliary_system	1.29994782
44	MP0004142_abnormal_muscle_tone	1.28883700
45	MP0002166_altered_tumor_susceptibility	1.26695942
46	MP0002653_abnormal_ependyma_morphology	1.26020035
47	MP0004043_abnormal_pH_regulation	1.25356603
48	MP0002735_abnormal_chemical_nociception	1.25070044
49	MP0009697_abnormal_copulation	1.24637274
50	MP0005253_abnormal_eye_physiology	1.23257673
51	MP0005389_reproductive_system_phenotype	1.21887803
52	MP0000685_abnormal_immune_system	1.20624485
53	MP0001984_abnormal_olfaction	1.19437570
54	MP0001486_abnormal_startle_reflex	1.17673850
55	MP0000427_abnormal_hair_cycle	1.17637606
56	MP0005084_abnormal_gallbladder_morpholo	1.12811024
57	MP0002420_abnormal_adaptive_immunity	1.11414677
58	MP0006276_abnormal_autonomic_nervous	1.09189114
59	MP0002723_abnormal_immune_serum	1.09028042
60	MP0001819_abnormal_immune_cell	1.08617002
61	MP0002006_tumorigenesis	1.07082641
62	MP0005025_abnormal_response_to	1.05811993
63	MP0005464_abnormal_platelet_physiology	1.04581273
64	MP0005266_abnormal_metabolism	1.04565591
65	MP0002452_abnormal_antigen_presenting	1.04313066
66	MP0009046_muscle_twitch	1.03256381
67	MP0009764_decreased_sensitivity_to	1.02947225
68	MP0009745_abnormal_behavioral_response	1.02600428
69	MP0005387_immune_system_phenotype	1.01164210
70	MP0001790_abnormal_immune_system	1.01164210
71	MP0002419_abnormal_innate_immunity	1.00791822
72	MP0001919_abnormal_reproductive_system	1.00333150
73	MP0005000_abnormal_immune_tolerance	0.98504155
74	MP0004885_abnormal_endolymph	0.97881556
75	MP0000689_abnormal_spleen_morphology	0.96366517
76	MP0002398_abnormal_bone_marrow	0.96082992
77	MP0000015_abnormal_ear_pigmentation	0.94876557
78	MP0000716_abnormal_immune_system	0.92970792
79	MP0003698_abnormal_male_reproductive	0.91659785
80	MP0002163_abnormal_gland_morphology	0.91215290
81	MP0006036_abnormal_mitochondrial_physio	0.89837509
82	MP0001929_abnormal_gametogenesis	0.86037630
83	MP0003724_increased_susceptibility_to	0.85947116
84	MP0008995_early_reproductive_senescence	0.85381319
85	MP0003136_yellow_coat_color	0.84790609
86	MP0002722_abnormal_immune_system	0.84249316
87	MP0001905_abnormal_dopamine_level	0.82470678
88	MP0001970_abnormal_pain_threshold	0.80189934
89	MP0002733_abnormal_thermal_nociception	0.79486083
90	MP0000465_gastrointestinal_hemorrhage	0.78662067
91	MP0010386_abnormal_urinary_bladder	0.77661193
92	MP0002272_abnormal_nervous_system	0.75636515
93	MP0003806_abnormal_nucleotide_metabolis	0.75004377
94	MP0003656_abnormal_erythrocyte_physiolo	0.74042524
95	MP0005379_endocrine/exocrine_gland_phen	0.73785032
96	MP0002693_abnormal_pancreas_physiology	0.73391770
97	MP0004742_abnormal_vestibular_system	0.73254649
98	MP0005386_behavior/neurological_phenoty	0.73226337
99	MP0004924_abnormal_behavior	0.73226337
100	MP0000631_abnormal_neuroendocrine_gland	0.72717318

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of B cell number (HP:0010975)	5.74944218
2	B lymphocytopenia (HP:0010976)	5.57951146
3	Severe combined immunodeficiency (HP:0004430)	4.88256977
4	Thyroiditis (HP:0100646)	4.66918202
5	Hypoproteinemia (HP:0003075)	4.28630095
6	Hypoplasia of the thymus (HP:0000778)	4.26049441
7	Panhypogammaglobulinemia (HP:0003139)	4.21930264
8	Eosinophilia (HP:0001880)	3.67943319
9	Combined immunodeficiency (HP:0005387)	3.60162321
10	Congenital stationary night blindness (HP:0007642)	3.39217431
11	Pancreatic cysts (HP:0001737)	3.37974109
12	Abnormality of eosinophils (HP:0001879)	3.25600080
13	Granulocytopenia (HP:0001913)	3.23135432
14	Pancreatic fibrosis (HP:0100732)	3.18062694
15	Attenuation of retinal blood vessels (HP:0007843)	3.15487365
16	Agammaglobulinemia (HP:0004432)	3.09249756
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.91335193
18	Abnormality of the renal cortex (HP:0011035)	2.88924162
19	Nephronophthisis (HP:0000090)	2.87682963
20	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86076013
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85483023
22	True hermaphroditism (HP:0010459)	2.80763693
23	Renal cortical cysts (HP:0000803)	2.78967785
24	T lymphocytopenia (HP:0005403)	2.75968828
25	Abnormality of the prostate (HP:0008775)	2.74904608
26	Abnormality of T cell number (HP:0011839)	2.68677026
27	Abnormality of the renal medulla (HP:0100957)	2.59618892
28	Medial flaring of the eyebrow (HP:0010747)	2.52129097
29	Abnormality of midbrain morphology (HP:0002418)	2.51192623
30	Molar tooth sign on MRI (HP:0002419)	2.51192623
31	IgG deficiency (HP:0004315)	2.47349883
32	Hepatocellular necrosis (HP:0001404)	2.47027648
33	Gaze-evoked nystagmus (HP:0000640)	2.39730233
34	Acute lymphatic leukemia (HP:0006721)	2.39696160
35	Thrombocytosis (HP:0001894)	2.34491468
36	Metaphyseal dysplasia (HP:0100255)	2.33973158
37	Stomach cancer (HP:0012126)	2.31428716
38	Hepatic necrosis (HP:0002605)	2.29554538
39	Chronic sinusitis (HP:0011109)	2.24945675
40	Mitochondrial inheritance (HP:0001427)	2.23726726
41	Decreased central vision (HP:0007663)	2.20857094
42	Recurrent fungal infections (HP:0002841)	2.20737801
43	Dicarboxylic aciduria (HP:0003215)	2.20306230
44	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.20306230
45	Leukocytosis (HP:0001974)	2.18246807
46	Chronic hepatic failure (HP:0100626)	2.17627258
47	Hypothermia (HP:0002045)	2.16626922
48	Constricted visual fields (HP:0001133)	2.16176510
49	Increased CSF lactate (HP:0002490)	2.15057693
50	Colon cancer (HP:0003003)	2.13637404
51	Methylmalonic aciduria (HP:0012120)	2.12154087
52	Type I transferrin isoform profile (HP:0003642)	2.09030932
53	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.08026681
54	Abnormal protein N-linked glycosylation (HP:0012347)	2.08026681
55	Abnormal protein glycosylation (HP:0012346)	2.08026681
56	Abnormal glycosylation (HP:0012345)	2.08026681
57	Hyperventilation (HP:0002883)	2.04379413
58	Dyschromatopsia (HP:0007641)	2.03296535
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00941329
60	Abnormality of T cells (HP:0002843)	2.00043952
61	Progressive cerebellar ataxia (HP:0002073)	1.98101482
62	Abolished electroretinogram (ERG) (HP:0000550)	1.97285576
63	Cystic liver disease (HP:0006706)	1.95304291
64	Methylmalonic acidemia (HP:0002912)	1.92693281
65	Ketosis (HP:0001946)	1.88361379
66	Tubulointerstitial nephritis (HP:0001970)	1.86495563
67	Stomatitis (HP:0010280)	1.86316265
68	Febrile seizures (HP:0002373)	1.85689007
69	Reduced antithrombin III activity (HP:0001976)	1.85584649
70	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.82526244
71	Abnormality of macular pigmentation (HP:0008002)	1.82391103
72	Abnormality of lateral ventricle (HP:0030047)	1.81442226
73	Meningitis (HP:0001287)	1.78402186
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.78318372
75	Central scotoma (HP:0000603)	1.77694913
76	Acute necrotizing encephalopathy (HP:0006965)	1.77388273
77	Prostate neoplasm (HP:0100787)	1.76621829
78	Erythroderma (HP:0001019)	1.75213122
79	Abnormality of male internal genitalia (HP:0000022)	1.74202010
80	Neutropenia (HP:0001875)	1.73683977
81	Albinism (HP:0001022)	1.73466407
82	Recurrent cutaneous fungal infections (HP:0011370)	1.73106147
83	Chronic mucocutaneous candidiasis (HP:0002728)	1.73106147
84	Progressive macrocephaly (HP:0004481)	1.73023629
85	Polydipsia (HP:0001959)	1.72310626
86	Abnormal drinking behavior (HP:0030082)	1.72310626
87	Microvesicular hepatic steatosis (HP:0001414)	1.72302404
88	Progressive microcephaly (HP:0000253)	1.70478580
89	Polyuria (HP:0000103)	1.70090824
90	Type II lissencephaly (HP:0007260)	1.69765227
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69470054
92	Chronic otitis media (HP:0000389)	1.69009004
93	Macular degeneration (HP:0000608)	1.68498424
94	Bile duct proliferation (HP:0001408)	1.68362484
95	Abnormal biliary tract physiology (HP:0012439)	1.68362484
96	Abnormal respiratory motile cilium morphology (HP:0005938)	1.67952477
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.67952477
98	Protruding tongue (HP:0010808)	1.67539209
99	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67481516
100	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.67218380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.27894663
2	MAP4K2	4.29078482
3	TXK	2.81137536
4	BCKDK	2.69900302
5	NUAK1	2.61546995
6	ZAK	2.59612820
7	PINK1	2.49343613
8	TAOK3	2.43675363
9	ADRBK2	2.42537910
10	KIT	2.26244190
11	PIK3CG	2.18094465
12	BMPR1B	2.05546714
13	FLT3	2.03715810
14	TNK2	2.00453629
15	VRK2	1.91917751
16	WNK3	1.88030545
17	GRK1	1.85937741
18	TEC	1.81590351
19	EIF2AK3	1.65091280
20	NLK	1.55290501
21	TLK1	1.49512184
22	MAPK13	1.48648191
23	MAP4K1	1.46412605
24	INSRR	1.37014968
25	STK38L	1.28445371
26	TRIM28	1.27132240
27	IKBKB	1.24451087
28	VRK1	1.18517568
29	SYK	1.16728032
30	BMPR2	1.16206423
31	TNIK	1.12935968
32	BTK	1.06922574
33	KDR	1.06335747
34	FES	1.03173928
35	ADRBK1	1.02919832
36	CSNK1A1L	0.97869360
37	CSNK1G3	0.97388449
38	PRKCE	0.96359493
39	MUSK	0.95315449
40	DYRK2	0.84065388
41	PRKCQ	0.83029026
42	RPS6KA5	0.82633101
43	CSNK1G2	0.79158413
44	MKNK1	0.77235837
45	OXSR1	0.76633580
46	ITK	0.75357727
47	CSNK1G1	0.74574940
48	DAPK2	0.73726208
49	MAPKAPK5	0.73322185
50	MAP3K12	0.72117158
51	MAP2K2	0.69638024
52	PLK4	0.69076205
53	LYN	0.69006401
54	PLK2	0.67233514
55	PIK3CA	0.67216007
56	MARK3	0.64706414
57	GRK6	0.63657423
58	DYRK3	0.63633018
59	CSF1R	0.60285261
60	ATR	0.59524909
61	TGFBR1	0.59069880
62	PTK2B	0.58950732
63	PIM2	0.58108378
64	RPS6KA4	0.57971332
65	IKBKE	0.56975935
66	GRK5	0.55231347
67	GRK7	0.51055732
68	MAP3K7	0.46154660
69	ACVR1B	0.45543893
70	CDK3	0.44473422
71	LCK	0.44233621
72	TESK2	0.42937921
73	PAK3	0.42776065
74	MAP2K7	0.41798402
75	CSNK1A1	0.40554336
76	CHEK2	0.39481581
77	FER	0.39380475
78	ABL2	0.38119321
79	ABL1	0.38103228
80	HCK	0.36380196
81	CASK	0.35659607
82	ATM	0.35653985
83	CAMK1	0.34949964
84	TBK1	0.34635517
85	RPS6KA6	0.34251490
86	PIM1	0.33747583
87	HIPK2	0.33685863
88	MAPKAPK3	0.32940198
89	CAMKK2	0.31731119
90	IGF1R	0.31639809
91	PRKCG	0.30568526
92	DYRK1A	0.30220870
93	MKNK2	0.30150946
94	CDK8	0.29615019
95	MAP3K11	0.29609523
96	PRKCI	0.29363515
97	SRPK1	0.29202150
98	CSNK1D	0.27951790
99	PRKACA	0.27899343
100	CDC7	0.27569222

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.39743714
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.14652346
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.04425151
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.92984187
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.87290732
6	Caffeine metabolism_Homo sapiens_hsa00232	2.57100361
7	Homologous recombination_Homo sapiens_hsa03440	2.15590197
8	Asthma_Homo sapiens_hsa05310	2.13730548
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.10161518
10	Butanoate metabolism_Homo sapiens_hsa00650	2.09061429
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08406640
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99351961
13	Fanconi anemia pathway_Homo sapiens_hsa03460	1.96041047
14	Olfactory transduction_Homo sapiens_hsa04740	1.70550477
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.70547179
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66608497
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.66487840
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.61687350
19	RNA polymerase_Homo sapiens_hsa03020	1.59485081
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.50775203
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.48014216
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.46110200
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.44841537
24	Protein export_Homo sapiens_hsa03060	1.36292133
25	Allograft rejection_Homo sapiens_hsa05330	1.36135465
26	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.34587469
27	Base excision repair_Homo sapiens_hsa03410	1.32503178
28	RNA degradation_Homo sapiens_hsa03018	1.27665617
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.26932988
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.26918091
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.26658957
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.26510727
33	Type I diabetes mellitus_Homo sapiens_hsa04940	1.23569995
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.22887958
35	Propanoate metabolism_Homo sapiens_hsa00640	1.22327838
36	Peroxisome_Homo sapiens_hsa04146	1.21367503
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19035800
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.17386392
39	Parkinsons disease_Homo sapiens_hsa05012	1.16318752
40	Regulation of autophagy_Homo sapiens_hsa04140	1.14205969
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13841042
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.13421394
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12155356
44	Selenocompound metabolism_Homo sapiens_hsa00450	1.10313388
45	Salivary secretion_Homo sapiens_hsa04970	1.07223370
46	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05078032
47	Basal transcription factors_Homo sapiens_hsa03022	0.99804873
48	Nicotine addiction_Homo sapiens_hsa05033	0.98005423
49	Retinol metabolism_Homo sapiens_hsa00830	0.97701829
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96773457
51	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96509495
52	Purine metabolism_Homo sapiens_hsa00230	0.94605770
53	ABC transporters_Homo sapiens_hsa02010	0.91315626
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90779652
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89511546
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86943780
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.86769979
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.85811273
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81552068
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.80093900
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.78507959
62	DNA replication_Homo sapiens_hsa03030	0.78470227
63	Taste transduction_Homo sapiens_hsa04742	0.77765935
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74297465
65	Huntingtons disease_Homo sapiens_hsa05016	0.70847154
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69084356
67	Circadian entrainment_Homo sapiens_hsa04713	0.68362468
68	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.66401625
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64048149
70	Metabolic pathways_Homo sapiens_hsa01100	0.63805081
71	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.62142966
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59021411
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58750987
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57989060
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57772271
76	Renin-angiotensin system_Homo sapiens_hsa04614	0.56915458
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56394454
78	Alzheimers disease_Homo sapiens_hsa05010	0.55628017
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.54104987
80	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52362970
81	Morphine addiction_Homo sapiens_hsa05032	0.49638611
82	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47782346
83	Fatty acid elongation_Homo sapiens_hsa00062	0.47215388
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.46827923
85	Mismatch repair_Homo sapiens_hsa03430	0.46104744
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45329349
87	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44952521
88	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.43690245
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.43441885
90	Serotonergic synapse_Homo sapiens_hsa04726	0.43079411
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42615826
92	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.42279601
93	Platelet activation_Homo sapiens_hsa04611	0.37724019
94	Sphingolipid metabolism_Homo sapiens_hsa00600	0.36029856
95	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.33942392
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33671050
97	Glutathione metabolism_Homo sapiens_hsa00480	0.32404802
98	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.32032039
99	Circadian rhythm_Homo sapiens_hsa04710	0.31236562
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30190817

AOX2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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