AOX3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)5.61057570
2negative regulation of B cell apoptotic process (GO:0002903)4.86859870
3aggressive behavior (GO:0002118)4.19489682
4regulation of chemokine biosynthetic process (GO:0045073)4.12039970
5response to pheromone (GO:0019236)4.09195254
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.05456957
7mitochondrion transport along microtubule (GO:0047497)4.05456957
8disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.04337331
9killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.04337331
10sperm motility (GO:0030317)3.99777173
11definitive hemopoiesis (GO:0060216)3.93476145
12single strand break repair (GO:0000012)3.88617935
13grooming behavior (GO:0007625)3.87799520
14positive regulation of prostaglandin secretion (GO:0032308)3.85489807
15cellular response to exogenous dsRNA (GO:0071360)3.80095375
16mast cell degranulation (GO:0043303)3.72603624
17mast cell activation involved in immune response (GO:0002279)3.72603624
18purine deoxyribonucleotide catabolic process (GO:0009155)3.72194045
19regulation of female gonad development (GO:2000194)3.67962745
20positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.66652894
21negative regulation of growth of symbiont in host (GO:0044130)3.63610503
22negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.63610503
23modulation of growth of symbiont involved in interaction with host (GO:0044144)3.63610503
24regulation of growth of symbiont in host (GO:0044126)3.63610503
25DNA deamination (GO:0045006)3.60134228
26regulation of female receptivity (GO:0045924)3.59427819
27metallo-sulfur cluster assembly (GO:0031163)3.58001462
28iron-sulfur cluster assembly (GO:0016226)3.58001462
29female mating behavior (GO:0060180)3.57946819
30positive regulation of icosanoid secretion (GO:0032305)3.54053998
31cellular extravasation (GO:0045123)3.50042810
32regulation of B cell apoptotic process (GO:0002902)3.39232553
33positive regulation of fatty acid transport (GO:2000193)3.38637985
34purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.37869634
35establishment of mitochondrion localization (GO:0051654)3.34904067
36acrosome reaction (GO:0007340)3.31366869
37hyperosmotic salinity response (GO:0042538)3.30577857
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.29977862
39neutrophil mediated immunity (GO:0002446)3.29613983
40spermatid development (GO:0007286)3.27747149
41purinergic nucleotide receptor signaling pathway (GO:0035590)3.27696063
42purine deoxyribonucleotide metabolic process (GO:0009151)3.26220814
43NAD biosynthetic process (GO:0009435)3.23958981
44mature B cell differentiation involved in immune response (GO:0002313)3.19496318
45fusion of sperm to egg plasma membrane (GO:0007342)3.18242838
46cell wall macromolecule catabolic process (GO:0016998)3.15355907
47male meiosis I (GO:0007141)3.14014162
48piRNA metabolic process (GO:0034587)3.13666201
49centriole replication (GO:0007099)3.12153349
50protein polyglutamylation (GO:0018095)3.12074312
51deoxyribonucleotide catabolic process (GO:0009264)3.10643327
52deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.05486435
53spermatid nucleus differentiation (GO:0007289)3.04690094
54lysosome localization (GO:0032418)3.04049936
55regulation of prostaglandin secretion (GO:0032306)3.04009709
56long term synaptic depression (GO:0060292)3.03786434
57tRNA methylation (GO:0030488)3.00536005
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00028859
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.00028859
60NADH dehydrogenase complex assembly (GO:0010257)3.00028859
61drinking behavior (GO:0042756)2.97705799
62cilium or flagellum-dependent cell motility (GO:0001539)2.95374835
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94847600
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94847600
65deoxyribose phosphate catabolic process (GO:0046386)2.93485821
66cell wall macromolecule metabolic process (GO:0044036)2.93114994
67cellular ketone body metabolic process (GO:0046950)2.91982590
68regulation of icosanoid secretion (GO:0032303)2.91849095
69L-fucose catabolic process (GO:0042355)2.91169942
70fucose catabolic process (GO:0019317)2.91169942
71L-fucose metabolic process (GO:0042354)2.91169942
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.90431135
73positive regulation of megakaryocyte differentiation (GO:0045654)2.86489257
74DNA methylation involved in gamete generation (GO:0043046)2.84882029
75regulation of germinal center formation (GO:0002634)2.83958139
76positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.82969480
77microtubule severing (GO:0051013)2.78956134
78positive regulation of B cell differentiation (GO:0045579)2.78729656
79cell differentiation involved in metanephros development (GO:0072202)2.77678938
80protein complex biogenesis (GO:0070271)2.77453227
81reactive oxygen species biosynthetic process (GO:1903409)2.76913302
82positive regulation of organic acid transport (GO:0032892)2.76821634
83meiosis I (GO:0007127)2.75126381
84mucosal-associated lymphoid tissue development (GO:0048537)2.74237670
85Peyers patch development (GO:0048541)2.74237670
86regulation of transmission of nerve impulse (GO:0051969)2.74016798
87multicellular organism reproduction (GO:0032504)2.73111667
88response to interferon-beta (GO:0035456)2.72834910
89mannosylation (GO:0097502)2.71179355
90estrogen biosynthetic process (GO:0006703)2.71067720
91mast cell activation (GO:0045576)2.67590091
92cellular response to interferon-beta (GO:0035458)2.66798472
93myeloid leukocyte mediated immunity (GO:0002444)2.66362541
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.61396549
95leukotriene biosynthetic process (GO:0019370)2.59563498
96regulation of protein kinase A signaling (GO:0010738)2.58680997
97regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.58089831
98positive regulation of granulocyte differentiation (GO:0030854)2.56847134
99mitochondrial calcium ion transport (GO:0006851)2.55823859
100negative regulation of interleukin-8 production (GO:0032717)2.55006263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.84064968
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.48787662
3SCL_19346495_ChIP-Seq_HPC-7_Human3.34605257
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19882216
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05220371
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.96095093
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.55068229
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.49756197
9VDR_21846776_ChIP-Seq_THP-1_Human2.29081403
10VDR_24763502_ChIP-Seq_THP-1_Human2.26466639
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.20515743
12ZNF274_21170338_ChIP-Seq_K562_Hela2.15317497
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14084985
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12875727
15EZH2_22144423_ChIP-Seq_EOC_Human1.98221555
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81738125
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79267442
18BCL6_27268052_Chip-Seq_Bcells_Human1.74759228
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.74364528
20MYB_26560356_Chip-Seq_TH2_Human1.69808857
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69055488
22SPI1_20517297_ChIP-Seq_HL60_Human1.68747633
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63488805
24E2F1_20622854_ChIP-Seq_HELA_Human1.62939862
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62453496
26P300_27268052_Chip-Seq_Bcells_Human1.61494331
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60993047
28YY1_22570637_ChIP-Seq_MALME-3M_Human1.60139126
29STAT1_20625510_ChIP-Seq_HELA_Human1.59447592
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57632976
31ERA_21632823_ChIP-Seq_H3396_Human1.55980878
32RUNX_20019798_ChIP-Seq_JUKART_Human1.55296373
33RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54286884
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53300713
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52566636
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50505774
37GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48420797
38BCOR_27268052_Chip-Seq_Bcells_Human1.47422303
39RAC3_21632823_ChIP-Seq_H3396_Human1.46897402
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42975616
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42412480
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.40407087
43UTX_26944678_Chip-Seq_JUKART_Human1.35676854
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35266319
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34994118
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.32654606
47PHF8_20622854_ChIP-Seq_HELA_Human1.32303939
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31949825
49P68_20966046_ChIP-Seq_HELA_Human1.31522649
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30483029
51CIITA_25753668_ChIP-Seq_RAJI_Human1.29660387
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28761270
53NANOG_20526341_ChIP-Seq_ESCs_Human1.28407458
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25733856
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25733856
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24937785
57GATA3_27048872_Chip-Seq_THYMUS_Human1.24078223
58SPI1_23127762_ChIP-Seq_K562_Human1.23952205
59GATA3_26560356_Chip-Seq_TH2_Human1.22800814
60CBP_20019798_ChIP-Seq_JUKART_Human1.22408990
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22408990
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22056876
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.21702443
64SPI1_23547873_ChIP-Seq_NB4_Human1.17081604
65CTCF_20526341_ChIP-Seq_ESCs_Human1.16630332
66VDR_24787735_ChIP-Seq_THP-1_Human1.15069368
67MYC_19829295_ChIP-Seq_ESCs_Human1.14149440
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.11174730
69NANOG_19829295_ChIP-Seq_ESCs_Human1.10576030
70SOX2_19829295_ChIP-Seq_ESCs_Human1.10576030
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.09683172
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09618515
73MYB_26560356_Chip-Seq_TH1_Human1.07822011
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07719855
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07544292
76VDR_23849224_ChIP-Seq_CD4+_Human1.07046391
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06167986
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05967228
79CEBPB_22108803_ChIP-Seq_LS180_Human1.05735338
80ERG_20517297_ChIP-Seq_VCAP_Human1.05100013
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04865539
82OCT4_20526341_ChIP-Seq_ESCs_Human1.04488710
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04282870
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04029575
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.02410149
86FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02410149
87OCT4_19829295_ChIP-Seq_ESCs_Human1.00760459
88GATA1_19941826_ChIP-Seq_K562_Human1.00151905
89GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99766730
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98967378
91TAF2_19829295_ChIP-Seq_ESCs_Human0.98787147
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97047549
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97022387
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95524538
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.95475798
96NCOR_22424771_ChIP-Seq_293T_Human0.95446860
97MAF_26560356_Chip-Seq_TH2_Human0.93627377
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93531398
99ER_23166858_ChIP-Seq_MCF-7_Human0.93143256
100P53_21459846_ChIP-Seq_SAOS-2_Human0.93018221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.59700999
2MP0005410_abnormal_fertilization4.07409475
3MP0001545_abnormal_hematopoietic_system3.86739858
4MP0005397_hematopoietic_system_phenotyp3.86739858
5MP0000569_abnormal_digit_pigmentation2.99140962
6MP0005670_abnormal_white_adipose2.93890935
7MP0003303_peritoneal_inflammation2.43843524
8MP0005645_abnormal_hypothalamus_physiol2.36548249
9MP0008057_abnormal_DNA_replication2.27830890
10MP0002138_abnormal_hepatobiliary_system2.14152171
11MP0003718_maternal_effect2.11533378
12MP0008877_abnormal_DNA_methylation2.08170385
13MP0002822_catalepsy2.07747567
14MP0003806_abnormal_nucleotide_metabolis2.07413740
15MP0005084_abnormal_gallbladder_morpholo2.06048338
16MP0002396_abnormal_hematopoietic_system2.01604203
17MP0003183_abnormal_peptide_metabolism1.89060015
18MP0008058_abnormal_DNA_repair1.83269978
19MP0003191_abnormal_cellular_cholesterol1.72146583
20MP0003698_abnormal_male_reproductive1.60759641
21MP0008875_abnormal_xenobiotic_pharmacok1.59148367
22MP0002653_abnormal_ependyma_morphology1.52719245
23MP0001986_abnormal_taste_sensitivity1.52240720
24MP0001835_abnormal_antigen_presentation1.52164327
25MP0001929_abnormal_gametogenesis1.50624497
26MP0005025_abnormal_response_to1.50408109
27MP0005464_abnormal_platelet_physiology1.48846397
28MP0005075_abnormal_melanosome_morpholog1.47600602
29MP0006276_abnormal_autonomic_nervous1.47175518
30MP0003172_abnormal_lysosome_physiology1.39511282
31MP0001800_abnormal_humoral_immune1.37328171
32MP0009697_abnormal_copulation1.35646175
33MP0000465_gastrointestinal_hemorrhage1.35601033
34MP0002419_abnormal_innate_immunity1.35175513
35MP0004742_abnormal_vestibular_system1.33574728
36MP0003252_abnormal_bile_duct1.33288354
37MP0003436_decreased_susceptibility_to1.33284893
38MP0008872_abnormal_physiological_respon1.32393978
39MP0009840_abnormal_foam_cell1.28521267
40MP0001819_abnormal_immune_cell1.25269787
41MP0002420_abnormal_adaptive_immunity1.25247438
42MP0000716_abnormal_immune_system1.24944843
43MP0001764_abnormal_homeostasis1.23505330
44MP0002723_abnormal_immune_serum1.22606799
45MP0005174_abnormal_tail_pigmentation1.21002657
46MP0002148_abnormal_hypersensitivity_rea1.20970883
47MP0002398_abnormal_bone_marrow1.20355485
48MP0001968_abnormal_touch/_nociception1.19088680
49MP0003724_increased_susceptibility_to1.18649846
50MP0005266_abnormal_metabolism1.18068099
51MP0006036_abnormal_mitochondrial_physio1.15960093
52MP0001905_abnormal_dopamine_level1.15508644
53MP0008995_early_reproductive_senescence1.14058935
54MP0005000_abnormal_immune_tolerance1.12612635
55MP0001486_abnormal_startle_reflex1.10663374
56MP0005377_hearing/vestibular/ear_phenot1.10628652
57MP0003878_abnormal_ear_physiology1.10628652
58MP0003646_muscle_fatigue1.10308441
59MP0009785_altered_susceptibility_to1.09658046
60MP0002452_abnormal_antigen_presenting1.07049527
61MP0005646_abnormal_pituitary_gland1.06792650
62MP0005666_abnormal_adipose_tissue1.06486513
63MP0000689_abnormal_spleen_morphology1.04781980
64MP0009046_muscle_twitch1.04157607
65MP0002722_abnormal_immune_system1.02809620
66MP0005423_abnormal_somatic_nervous1.01130027
67MP0002429_abnormal_blood_cell0.98617501
68MP0009379_abnormal_foot_pigmentation0.95736497
69MP0003763_abnormal_thymus_physiology0.95726724
70MP0001485_abnormal_pinna_reflex0.94967228
71MP0005220_abnormal_exocrine_pancreas0.94675774
72MP0001853_heart_inflammation0.94486403
73MP0000685_abnormal_immune_system0.94384459
74MP0006292_abnormal_olfactory_placode0.93048700
75MP0000653_abnormal_sex_gland0.92996196
76MP0002160_abnormal_reproductive_system0.92659195
77MP0000230_abnormal_systemic_arterial0.92204198
78MP0005387_immune_system_phenotype0.91964451
79MP0001790_abnormal_immune_system0.91964451
80MP0009764_decreased_sensitivity_to0.91339374
81MP0008873_increased_physiological_sensi0.87484951
82MP0002019_abnormal_tumor_incidence0.87334735
83MP0005671_abnormal_response_to0.86118538
84MP0002735_abnormal_chemical_nociception0.85795382
85MP0001145_abnormal_male_reproductive0.85263458
86MP0002229_neurodegeneration0.82739373
87MP0002405_respiratory_system_inflammati0.81319611
88MP0003950_abnormal_plasma_membrane0.78443623
89MP0005376_homeostasis/metabolism_phenot0.78040289
90MP0004147_increased_porphyrin_level0.77316291
91MP0002161_abnormal_fertility/fecundity0.77219121
92MP0002210_abnormal_sex_determination0.75446509
93MP0004043_abnormal_pH_regulation0.75396146
94MP0008469_abnormal_protein_level0.73523851
95MP0002733_abnormal_thermal_nociception0.72586256
96MP0005058_abnormal_lysosome_morphology0.71694852
97MP0005551_abnormal_eye_electrophysiolog0.71600770
98MP0003880_abnormal_central_pattern0.71432292
99MP0002876_abnormal_thyroid_physiology0.71105105
100MP0002971_abnormal_brown_adipose0.70139292

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)6.52987869
2Abnormality of B cell number (HP:0010975)5.10972132
3Thrombocytosis (HP:0001894)4.84764092
4B lymphocytopenia (HP:0010976)4.65840959
5Microvesicular hepatic steatosis (HP:0001414)4.61972417
6Eosinophilia (HP:0001880)3.62276432
7Hypoplasia of the thymus (HP:0000778)3.59703408
8Tubulointerstitial nephritis (HP:0001970)3.55623602
9Decreased central vision (HP:0007663)3.52900120
10Granulocytopenia (HP:0001913)3.47993828
11Elevated erythrocyte sedimentation rate (HP:0003565)3.42708878
12Abnormal rod and cone electroretinograms (HP:0008323)3.39453269
13Panhypogammaglobulinemia (HP:0003139)3.25459623
14Severe visual impairment (HP:0001141)3.24235792
15Severe combined immunodeficiency (HP:0004430)3.10929647
16Recurrent pneumonia (HP:0006532)3.06293572
17Abnormality of the prostate (HP:0008775)3.00130354
18Decreased electroretinogram (ERG) amplitude (HP:0000654)2.99821518
19Congenital stationary night blindness (HP:0007642)2.97169931
20Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87825710
21Chronic obstructive pulmonary disease (HP:0006510)2.85899588
22Obstructive lung disease (HP:0006536)2.85899588
23Meningitis (HP:0001287)2.85471664
24Genetic anticipation (HP:0003743)2.84140131
25Acute myeloid leukemia (HP:0004808)2.83519511
26Cellulitis (HP:0100658)2.80305829
27Papilloma (HP:0012740)2.79258983
28Verrucae (HP:0200043)2.79258983
29Acute lymphatic leukemia (HP:0006721)2.76062747
30Increased IgE level (HP:0003212)2.73089295
31Abnormality of eosinophils (HP:0001879)2.70204330
32Abnormal number of erythroid precursors (HP:0012131)2.65134253
33Hepatocellular necrosis (HP:0001404)2.64168557
34Type 2 muscle fiber atrophy (HP:0003554)2.59590076
35Attenuation of retinal blood vessels (HP:0007843)2.57577457
36Abnormal mitochondria in muscle tissue (HP:0008316)2.56772390
37Mitochondrial inheritance (HP:0001427)2.54579679
38Seborrheic dermatitis (HP:0001051)2.53814646
39Aplasia/Hypoplasia of the thymus (HP:0010515)2.47713940
40Acute necrotizing encephalopathy (HP:0006965)2.46740466
41Cerebral edema (HP:0002181)2.46145318
42Leukocytosis (HP:0001974)2.41968901
43Sepsis (HP:0100806)2.41445525
44Hepatic necrosis (HP:0002605)2.39450720
45Muscle fiber atrophy (HP:0100295)2.39400922
46Nephronophthisis (HP:0000090)2.36380885
47Type I transferrin isoform profile (HP:0003642)2.35302929
48Abnormality of cells of the erythroid lineage (HP:0012130)2.34412078
49Autoimmune thrombocytopenia (HP:0001973)2.33943121
50Skin rash (HP:0000988)2.30580341
51Periodontitis (HP:0000704)2.27989191
52Hyperthyroidism (HP:0000836)2.24864539
53Impulsivity (HP:0100710)2.23382932
54Abnormality of the columella (HP:0009929)2.23070690
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22677706
56Dicarboxylic aciduria (HP:0003215)2.22677706
57Abnormality of T cell physiology (HP:0011840)2.21775301
58Bony spicule pigmentary retinopathy (HP:0007737)2.21655377
59Hypergammaglobulinemia (HP:0010702)2.21624036
60Abnormal biliary tract physiology (HP:0012439)2.20890005
61Bile duct proliferation (HP:0001408)2.20890005
62Recurrent lower respiratory tract infections (HP:0002783)2.20724198
63Combined immunodeficiency (HP:0005387)2.19823422
64Progressive cerebellar ataxia (HP:0002073)2.18900324
65Progressive muscle weakness (HP:0003323)2.18570168
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17554697
67Abnormal protein N-linked glycosylation (HP:0012347)2.17554697
68Abnormal protein glycosylation (HP:0012346)2.17554697
69Abnormal glycosylation (HP:0012345)2.17554697
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.12136454
71Abnormality of the renal medulla (HP:0100957)2.12089958
72Thyroiditis (HP:0100646)2.11290776
73Abnormality of transition element cation homeostasis (HP:0011030)2.08274338
74Progressive microcephaly (HP:0000253)2.05374339
75Increased CSF lactate (HP:0002490)2.04465873
76Cerebral palsy (HP:0100021)2.02954338
77Progressive macrocephaly (HP:0004481)1.98714803
78Cone-rod dystrophy (HP:0000548)1.98211077
79Neutropenia (HP:0001875)1.97717463
80Chronic sinusitis (HP:0011109)1.96514750
81Increased serum ferritin (HP:0003281)1.91899181
82Osteomyelitis (HP:0002754)1.90550771
83Acute encephalopathy (HP:0006846)1.90346583
84Hypertensive crisis (HP:0100735)1.89658028
85Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89384909
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86821607
87Generalized aminoaciduria (HP:0002909)1.86094315
88Dynein arm defect of respiratory motile cilia (HP:0012255)1.85762159
89Absent/shortened dynein arms (HP:0200106)1.85762159
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85039128
91Pancreatic cysts (HP:0001737)1.81683670
92Recurrent fungal infections (HP:0002841)1.80869011
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79342846
94Portal hypertension (HP:0001409)1.79210407
95Abnormality of the renal cortex (HP:0011035)1.75637873
96Severe global developmental delay (HP:0011344)1.75520983
97Abnormality of iron homeostasis (HP:0011031)1.74235729
98Prostate neoplasm (HP:0100787)1.73074680
99Abnormality of pyrimidine metabolism (HP:0004353)1.71731422
100Abnormality of the pleura (HP:0002103)1.71520059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.92062145
2VRK23.28988048
3KIT3.24955351
4MAP4K23.17406658
5KDR3.11380224
6SCYL23.02665302
7PIK3CG2.85666755
8NUAK12.74969622
9TAOK32.72287504
10BCKDK2.63798293
11MAP3K112.50942336
12FLT32.49203458
13FRK2.23132288
14MAP4K12.12184831
15PLK42.01343963
16ERN11.97359211
17INSRR1.97338427
18ZAK1.92472548
19TESK11.67650184
20MAPKAPK31.63163084
21GRK11.52985416
22TNK21.37045786
23CDK121.35226713
24SYK1.34912342
25PINK11.32031874
26PTK2B1.27813718
27TEC1.22302687
28VRK11.22075801
29ICK1.19240638
30MAPKAPK51.18226191
31MAPK111.14508353
32JAK31.12914704
33BTK1.03115463
34IKBKB0.97564045
35DDR20.96004514
36RPS6KA50.91241261
37FES0.89200319
38TAF10.84065705
39BMPR1B0.81993407
40BMPR20.81800470
41RPS6KA60.80842028
42STK380.80684717
43MAP3K130.80511495
44ABL20.75499936
45LYN0.73590539
46CCNB10.72193367
47RPS6KC10.71367995
48RPS6KL10.71367995
49DYRK1B0.67357589
50MAP2K20.64625702
51MAPK150.60075724
52CSF1R0.60022719
53OXSR10.57511921
54CDK90.57509747
55NME20.56449787
56LCK0.54298680
57PBK0.52530021
58TLK10.51574835
59RPS6KB20.50567153
60MAPK130.49796388
61ACVR1B0.49612862
62TIE10.48689110
63PDK10.46473500
64ATR0.44460986
65PRKCQ0.43761222
66CAMK10.43701061
67PIM20.43660650
68MARK30.43607489
69GRK60.42780873
70DYRK1A0.42424949
71TBK10.41766326
72MAPK30.41345029
73TXK0.40572459
74RIPK40.40550645
75PRKAA20.40416200
76HIPK20.39734738
77MAP3K70.38966176
78PIM10.38355592
79DAPK10.35977719
80SRPK10.35748978
81MAPK120.35030982
82CHEK20.34999435
83ITK0.34102637
84LIMK10.33563218
85PKN10.33332440
86MAPK10.32889224
87MAPK40.32571443
88CDK30.32536279
89ADRBK20.32523832
90CDK60.32321606
91PIK3CA0.32080301
92CDK70.30622181
93DAPK20.30367264
94STK390.30213363
95PDPK10.29985922
96PRKAA10.29395099
97PRKD20.29013225
98CDK40.27366408
99MATK0.27091440
100ARAF0.26110330

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.02222103
2Asthma_Homo sapiens_hsa053102.78099169
3Phototransduction_Homo sapiens_hsa047442.73354693
4Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.53525819
5Base excision repair_Homo sapiens_hsa034102.41607896
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.20131541
7Allograft rejection_Homo sapiens_hsa053302.18784742
8Olfactory transduction_Homo sapiens_hsa047402.17004043
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16262735
10Butanoate metabolism_Homo sapiens_hsa006502.09017341
11Graft-versus-host disease_Homo sapiens_hsa053321.91650922
12Autoimmune thyroid disease_Homo sapiens_hsa053201.78393148
13Antigen processing and presentation_Homo sapiens_hsa046121.78009882
14Type I diabetes mellitus_Homo sapiens_hsa049401.77904244
15Homologous recombination_Homo sapiens_hsa034401.74812398
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.74034676
17Systemic lupus erythematosus_Homo sapiens_hsa053221.68323837
18Fanconi anemia pathway_Homo sapiens_hsa034601.68147475
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67141365
20DNA replication_Homo sapiens_hsa030301.52263170
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51807312
22Ribosome_Homo sapiens_hsa030101.48208601
23Peroxisome_Homo sapiens_hsa041461.39876865
24Linoleic acid metabolism_Homo sapiens_hsa005911.39734340
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31792765
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30674646
27Salivary secretion_Homo sapiens_hsa049701.24055272
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23977572
29Tyrosine metabolism_Homo sapiens_hsa003501.23838180
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19111060
31Purine metabolism_Homo sapiens_hsa002301.16858956
32Hematopoietic cell lineage_Homo sapiens_hsa046401.16764590
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.13133088
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12135872
35Staphylococcus aureus infection_Homo sapiens_hsa051501.11766290
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11354693
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11079673
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.10513815
39Caffeine metabolism_Homo sapiens_hsa002321.09004550
40Tryptophan metabolism_Homo sapiens_hsa003801.08916693
41Renin secretion_Homo sapiens_hsa049241.08323290
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.07460633
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06581116
44Arachidonic acid metabolism_Homo sapiens_hsa005901.05306337
45Fatty acid biosynthesis_Homo sapiens_hsa000611.02439874
46Chemical carcinogenesis_Homo sapiens_hsa052041.00202109
47ABC transporters_Homo sapiens_hsa020101.00105211
48Pyrimidine metabolism_Homo sapiens_hsa002401.00104014
49Platelet activation_Homo sapiens_hsa046110.99552279
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99318200
51Other glycan degradation_Homo sapiens_hsa005110.98749184
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.93957424
53Parkinsons disease_Homo sapiens_hsa050120.89937787
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89181041
55Retinol metabolism_Homo sapiens_hsa008300.87773899
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86909731
57Sulfur relay system_Homo sapiens_hsa041220.84857890
58Acute myeloid leukemia_Homo sapiens_hsa052210.84323424
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83662418
60African trypanosomiasis_Homo sapiens_hsa051430.83531361
61Renin-angiotensin system_Homo sapiens_hsa046140.82839805
62Leishmaniasis_Homo sapiens_hsa051400.82308436
63Huntingtons disease_Homo sapiens_hsa050160.78043664
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77926162
65Calcium signaling pathway_Homo sapiens_hsa040200.77731443
66Oxidative phosphorylation_Homo sapiens_hsa001900.75141348
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67947585
68Fatty acid metabolism_Homo sapiens_hsa012120.65968487
69Phenylalanine metabolism_Homo sapiens_hsa003600.65587613
70B cell receptor signaling pathway_Homo sapiens_hsa046620.65084161
71Non-homologous end-joining_Homo sapiens_hsa034500.64964408
72Fatty acid elongation_Homo sapiens_hsa000620.59105703
73Regulation of autophagy_Homo sapiens_hsa041400.58865433
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58217141
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55354584
76Proteasome_Homo sapiens_hsa030500.54189677
77Fatty acid degradation_Homo sapiens_hsa000710.54075996
78Ovarian steroidogenesis_Homo sapiens_hsa049130.53995898
79Metabolic pathways_Homo sapiens_hsa011000.51332463
80Taste transduction_Homo sapiens_hsa047420.51209517
81Ether lipid metabolism_Homo sapiens_hsa005650.50610763
82Influenza A_Homo sapiens_hsa051640.50513115
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50377921
84Propanoate metabolism_Homo sapiens_hsa006400.48922912
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47542495
86Rheumatoid arthritis_Homo sapiens_hsa053230.47509839
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44523759
88Nitrogen metabolism_Homo sapiens_hsa009100.43797853
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43640626
90beta-Alanine metabolism_Homo sapiens_hsa004100.43537794
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43233097
92Mismatch repair_Homo sapiens_hsa034300.42055297
93Glycerolipid metabolism_Homo sapiens_hsa005610.39177333
94Cardiac muscle contraction_Homo sapiens_hsa042600.38787084
95Herpes simplex infection_Homo sapiens_hsa051680.38590897
96Oxytocin signaling pathway_Homo sapiens_hsa049210.38079426
97Nucleotide excision repair_Homo sapiens_hsa034200.36590732
98RNA polymerase_Homo sapiens_hsa030200.34135155
99Alzheimers disease_Homo sapiens_hsa050100.32988748
100Lysine degradation_Homo sapiens_hsa003100.31795706

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »