AP1AR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.47714027
2synaptic vesicle maturation (GO:0016188)5.39058638
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.29397605
4locomotory exploration behavior (GO:0035641)5.28095549
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06256085
6mitotic sister chromatid cohesion (GO:0007064)4.83174869
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.63572018
8nuclear pore organization (GO:0006999)4.60627612
9positive regulation of dendritic spine morphogenesis (GO:0061003)4.58305694
10nuclear pore complex assembly (GO:0051292)4.52939428
11regulation of synaptic vesicle exocytosis (GO:2000300)4.28124686
12glutamate secretion (GO:0014047)4.26642335
13vocalization behavior (GO:0071625)4.25522389
14synaptic vesicle exocytosis (GO:0016079)4.20120469
15regulation of Golgi to plasma membrane protein transport (GO:0042996)4.10280065
16exploration behavior (GO:0035640)4.09566122
17protein localization to synapse (GO:0035418)4.07058157
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.06613865
19ribosome assembly (GO:0042255)4.06368333
20regulation of dendritic spine morphogenesis (GO:0061001)4.06011130
21regulation of glutamate receptor signaling pathway (GO:1900449)4.01162412
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95942853
23DNA topological change (GO:0006265)3.95549373
24neuronal action potential propagation (GO:0019227)3.93905723
25DNA double-strand break processing (GO:0000729)3.91356337
26sodium ion export (GO:0071436)3.80339991
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.80153399
28cellular potassium ion homeostasis (GO:0030007)3.78549332
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.77786852
30regulation of synaptic vesicle transport (GO:1902803)3.77416883
31proline transport (GO:0015824)3.72663260
32negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.67460111
33regulation of neuronal synaptic plasticity (GO:0048168)3.65278054
34dendritic spine morphogenesis (GO:0060997)3.61087880
35neurotransmitter secretion (GO:0007269)3.58805290
36regulation of synapse structural plasticity (GO:0051823)3.57208108
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.53052223
38activation of protein kinase A activity (GO:0034199)3.52733718
39cell migration in hindbrain (GO:0021535)3.50275479
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.50077681
41regulation of ARF protein signal transduction (GO:0032012)3.46787213
42neuron cell-cell adhesion (GO:0007158)3.40384788
43glutamate receptor signaling pathway (GO:0007215)3.39678631
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38601606
45positive regulation of cell cycle checkpoint (GO:1901978)3.36459163
46neuromuscular process controlling balance (GO:0050885)3.35786199
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35002412
48regulation of centriole replication (GO:0046599)3.34267370
49attachment of spindle microtubules to kinetochore (GO:0008608)3.32949991
50establishment of integrated proviral latency (GO:0075713)3.32031109
51pore complex assembly (GO:0046931)3.31562574
52DNA ligation (GO:0006266)3.27840722
53mitotic metaphase plate congression (GO:0007080)3.26880448
54regulation of clathrin-mediated endocytosis (GO:2000369)3.26848707
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25890264
56cellular protein complex localization (GO:0034629)3.25487133
57vesicle transport along microtubule (GO:0047496)3.24902806
58positive regulation of dendritic spine development (GO:0060999)3.21318350
59prepulse inhibition (GO:0060134)3.20472399
60non-recombinational repair (GO:0000726)3.19985286
61double-strand break repair via nonhomologous end joining (GO:0006303)3.19985286
62positive regulation of synapse maturation (GO:0090129)3.19686219
63membrane repolarization (GO:0086009)3.18394456
64synaptic transmission, glutamatergic (GO:0035249)3.18364696
65cerebellar Purkinje cell differentiation (GO:0021702)3.17858750
66regulation of sister chromatid cohesion (GO:0007063)3.16915192
67cell communication by electrical coupling (GO:0010644)3.12011292
68regulation of dendritic spine development (GO:0060998)3.11633304
69membrane depolarization during action potential (GO:0086010)3.11001082
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08900878
71dendrite morphogenesis (GO:0048813)3.07947826
72transcription from mitochondrial promoter (GO:0006390)3.07826294
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06676224
74long-term memory (GO:0007616)3.06219546
75neuron-neuron synaptic transmission (GO:0007270)3.06193698
76COPII vesicle coating (GO:0048208)3.02579758
77dopamine receptor signaling pathway (GO:0007212)3.02271822
78neuron recognition (GO:0008038)3.01779921
79regulation of synaptic plasticity (GO:0048167)3.01318613
80protein localization to kinetochore (GO:0034501)3.00603138
81positive regulation of mitochondrial fission (GO:0090141)2.99352353
82protein complex localization (GO:0031503)2.97879289
83behavioral defense response (GO:0002209)2.97813071
84behavioral fear response (GO:0001662)2.97813071
85ribonucleoprotein complex disassembly (GO:0032988)2.95845002
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95548670
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94524999
88regulation of mitotic spindle checkpoint (GO:1903504)2.94524999
89regulation of postsynaptic membrane potential (GO:0060078)2.94287249
90negative regulation of DNA recombination (GO:0045910)2.92262021
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91041525
92gamma-aminobutyric acid transport (GO:0015812)2.90210126
93cell communication involved in cardiac conduction (GO:0086065)2.90081105
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.89545768
95innervation (GO:0060384)2.89425028
96positive regulation of neurotransmitter secretion (GO:0001956)2.88414647
97organelle disassembly (GO:1903008)2.87267842
98IMP biosynthetic process (GO:0006188)2.86952687
99peptidyl-histidine modification (GO:0018202)2.85937968
100protein localization to chromosome, centromeric region (GO:0071459)2.85926160
101spermatid nucleus differentiation (GO:0007289)2.85319506
102response to histamine (GO:0034776)2.85198983
103termination of RNA polymerase II transcription (GO:0006369)2.84836302
104establishment of nucleus localization (GO:0040023)2.84585541
105axonal fasciculation (GO:0007413)2.84416520
106regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.84403438
107dendritic spine organization (GO:0097061)2.84262161
108sister chromatid segregation (GO:0000819)2.83790988
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.83405958
110purine nucleobase biosynthetic process (GO:0009113)2.82150230
111regulation of Rac protein signal transduction (GO:0035020)2.81924842
112membrane budding (GO:0006900)2.81697533
113metaphase plate congression (GO:0051310)2.81123463
114neurotransmitter-gated ion channel clustering (GO:0072578)2.80345661
115mitotic spindle checkpoint (GO:0071174)2.80177030
116amino acid salvage (GO:0043102)2.80047227
117L-methionine salvage (GO:0071267)2.80047227
118L-methionine biosynthetic process (GO:0071265)2.80047227
119regulation of helicase activity (GO:0051095)2.80014777
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.79872450
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.79872450
122IMP metabolic process (GO:0046040)2.79444925
123positive regulation of cell size (GO:0045793)2.79186124
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78979095
125positive regulation of neurotransmitter transport (GO:0051590)2.78695944
126fear response (GO:0042596)2.78418439
127neural tube formation (GO:0001841)2.78029810
128spindle checkpoint (GO:0031577)2.77861241
129DNA damage response, detection of DNA damage (GO:0042769)2.77755791
130regulation of translational elongation (GO:0006448)2.77115091
131organelle transport along microtubule (GO:0072384)2.76632360
132neurotransmitter transport (GO:0006836)2.76595799
133adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.76414681
134intraspecies interaction between organisms (GO:0051703)2.75774685
135social behavior (GO:0035176)2.75774685
136positive regulation of membrane potential (GO:0045838)2.75085110
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.74331654
138negative regulation of sister chromatid segregation (GO:0033046)2.74331654
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74331654
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74331654
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74331654
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.74133510
143positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74133510
144positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74133510
145negative regulation of microtubule polymerization (GO:0031115)2.74131622
146formation of translation preinitiation complex (GO:0001731)2.73519000
147negative regulation of dendrite development (GO:2000171)2.73160130
148tRNA aminoacylation for protein translation (GO:0006418)2.73092282
149transmission of nerve impulse (GO:0019226)2.72828307
150synaptic vesicle endocytosis (GO:0048488)2.70521549
151amino acid activation (GO:0043038)2.70299856
152tRNA aminoacylation (GO:0043039)2.70299856
153pre-miRNA processing (GO:0031054)2.69553384
154negative regulation of chromosome segregation (GO:0051985)2.69498890
155negative regulation of sodium ion transport (GO:0010766)2.69087262
156regulation of sister chromatid segregation (GO:0033045)2.68157146
157regulation of mitotic sister chromatid separation (GO:0010965)2.68157146
158regulation of mitotic sister chromatid segregation (GO:0033047)2.68157146
159negative regulation of dendrite morphogenesis (GO:0050774)2.67529217
160suckling behavior (GO:0001967)2.67117734
161membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.66272121
162regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66095320
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.65701002
164regulation of neurotransmitter secretion (GO:0046928)2.65561603
165mating behavior (GO:0007617)2.65513047
166positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.64954947
167negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64798605
168ether lipid metabolic process (GO:0046485)2.64680708
169peptidyl-threonine phosphorylation (GO:0018107)2.63828583
170regulation of spindle organization (GO:0090224)2.63784376
171peptidyl-lysine dimethylation (GO:0018027)2.63711679
172clathrin coat assembly (GO:0048268)2.63610709
173mRNA 3-end processing (GO:0031124)2.63351164
174positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.61115502
175mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.61115502
176CENP-A containing nucleosome assembly (GO:0034080)2.58421691
177regulation of chromosome segregation (GO:0051983)2.57404633
178regulation of centrosome duplication (GO:0010824)2.56479689
179establishment of viral latency (GO:0019043)2.56151235
180response to lipoprotein particle (GO:0055094)2.55988691
181mitotic spindle assembly checkpoint (GO:0007094)2.55252390
182positive regulation of mRNA processing (GO:0050685)2.53562980
183C4-dicarboxylate transport (GO:0015740)2.53015109
184negative regulation of receptor activity (GO:2000272)2.52650154
185regulation of growth hormone secretion (GO:0060123)2.51867417
186magnesium ion transport (GO:0015693)2.50775630
187spindle assembly checkpoint (GO:0071173)2.50668825
188mitotic nuclear envelope disassembly (GO:0007077)2.49320816
189cholesterol biosynthetic process (GO:0006695)2.49193727
190chromatin remodeling at centromere (GO:0031055)2.48977862
191de novo protein folding (GO:0006458)2.48500748
192mitochondrial RNA metabolic process (GO:0000959)2.47597314
193mitochondrial fission (GO:0000266)2.46523929
194keratinocyte development (GO:0003334)2.46443780
195establishment of chromosome localization (GO:0051303)2.45521153
196regulation of mRNA splicing, via spliceosome (GO:0048024)2.43900818
197positive regulation of mRNA 3-end processing (GO:0031442)2.41227601
198regulation of pigment cell differentiation (GO:0050932)2.41118448
199de novo posttranslational protein folding (GO:0051084)2.39919929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40383804
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11111689
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.10002074
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95365561
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93165827
6IGF1R_20145208_ChIP-Seq_DFB_Human2.91924384
7PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.83860676
8E2F7_22180533_ChIP-Seq_HELA_Human2.81408648
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75125904
10ELK1_19687146_ChIP-ChIP_HELA_Human2.68185311
11AR_21909140_ChIP-Seq_LNCAP_Human2.62694880
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58071841
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.50489212
14FUS_26573619_Chip-Seq_HEK293_Human2.50046302
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49042946
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.37199113
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35642294
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.35626818
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35072456
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35072456
21REST_21632747_ChIP-Seq_MESCs_Mouse2.34323253
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.33266111
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.31769847
24EWS_26573619_Chip-Seq_HEK293_Human2.25971461
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23958639
26DROSHA_22980978_ChIP-Seq_HELA_Human2.19726893
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.18116618
28MYC_18555785_ChIP-Seq_MESCs_Mouse2.14671934
29GBX2_23144817_ChIP-Seq_PC3_Human2.13331253
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08925611
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07199320
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06047348
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02413208
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01550559
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94908907
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.92172272
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87741318
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87409439
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86886583
40DCP1A_22483619_ChIP-Seq_HELA_Human1.84872206
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.83478760
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.82064334
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80657983
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79912091
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.77048189
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75753277
47TAF15_26573619_Chip-Seq_HEK293_Human1.75413616
48VDR_23849224_ChIP-Seq_CD4+_Human1.75175080
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73716174
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73395300
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73009098
52KDM2B_26808549_Chip-Seq_K562_Human1.72997344
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72772729
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69704294
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.69222465
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68400025
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68188759
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63603790
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63107150
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62500786
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.62465714
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.61359029
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60322979
64ZNF274_21170338_ChIP-Seq_K562_Hela1.59759868
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58961386
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58558659
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58162053
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58078688
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58041824
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58030278
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57687938
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55182965
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55042850
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.48387111
75ZNF263_19887448_ChIP-Seq_K562_Human1.48304825
76SMAD4_21799915_ChIP-Seq_A2780_Human1.47022216
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46935327
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.46325289
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45765830
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.45757249
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.45607010
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43323201
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43288992
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41756260
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41439281
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.41342723
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39536900
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38172565
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37860240
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37703308
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37532586
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37197066
93TP53_16413492_ChIP-PET_HCT116_Human1.36685691
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.35914573
95ETS1_20019798_ChIP-Seq_JURKAT_Human1.35773981
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.35411800
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.33913974
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33453490
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31749840
100AHR_22903824_ChIP-Seq_MCF-7_Human1.31624249
101NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31443827
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31407010
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.31367634
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30395045
105FOXP3_21729870_ChIP-Seq_TREG_Human1.29095349
106AR_19668381_ChIP-Seq_PC3_Human1.28873284
107IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28869349
108FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27365232
109MYC_18940864_ChIP-ChIP_HL60_Human1.26996769
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26129824
111KDM2B_26808549_Chip-Seq_DND41_Human1.26037930
112AR_21572438_ChIP-Seq_LNCaP_Human1.25968230
113HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25841323
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.25646675
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.25585532
116KDM2B_26808549_Chip-Seq_JURKAT_Human1.25306236
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25029723
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23437490
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23174048
120STAT3_23295773_ChIP-Seq_U87_Human1.23126215
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22969978
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22591829
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22369094
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21770997
125GABP_19822575_ChIP-Seq_HepG2_Human1.21246802
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20632587
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20617119
128PKCTHETA_26484144_Chip-Seq_BREAST_Human1.20403896
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.20031781
130E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19404843
131FOXM1_23109430_ChIP-Seq_U2OS_Human1.19093573
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18934063
133TTF2_22483619_ChIP-Seq_HELA_Human1.16991053
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16856120
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15907477
136ER_23166858_ChIP-Seq_MCF-7_Human1.14328076
137HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13205891
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10704666
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.10497154
140ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10016809
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08690284
142MYC_22102868_ChIP-Seq_BL_Human1.08193676
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08172592
144CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07972558
145* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07829916
146REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07209936
147NANOG_18555785_Chip-Seq_ESCs_Mouse1.07208502
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05584501
149DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04887706
150TCF4_23295773_ChIP-Seq_U87_Human1.04258095
151MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03887486
152AR_25329375_ChIP-Seq_VCAP_Human1.03753971
153BCAT_22108803_ChIP-Seq_LS180_Human1.02777076
154TCF4_18268006_ChIP-ChIP_LS174T_Human1.01792521
155TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01726687
156EZH2_27294783_Chip-Seq_NPCs_Mouse1.01090737
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00719047
158SOX17_20123909_ChIP-Seq_XEN_Mouse1.00508178
159TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00370531
160SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00175875
161RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99980802
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99405371
163ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98066972
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.97839459
165ELF5_23300383_ChIP-Seq_T47D_Human0.97612661
166ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97430838
167TFEB_21752829_ChIP-Seq_HELA_Human0.97197396
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96933253
169CREB1_26743006_Chip-Seq_LNCaP_Human0.95675973
170TCF7_22412390_ChIP-Seq_EML_Mouse0.95617872
171P300_19829295_ChIP-Seq_ESCs_Human0.95291427
172VDR_22108803_ChIP-Seq_LS180_Human0.94976542
173P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94713573
174EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94538545
175SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94205038
176CDX2_22108803_ChIP-Seq_LS180_Human0.93835721
177PIAS1_25552417_ChIP-Seq_VCAP_Human0.93645607
178THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93108412
179NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92511623
180P53_22387025_ChIP-Seq_ESCs_Mouse0.92397365
181TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91965761
182CMYC_18555785_Chip-Seq_ESCs_Mouse0.91549927
183NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91268783
184NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91268783
185KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90427431
186SOX2_16153702_ChIP-ChIP_HESCs_Human0.90334722
187CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89302752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.21051037
2MP0004270_analgesia4.10132551
3MP0009697_abnormal_copulation3.88461658
4MP0003635_abnormal_synaptic_transmissio3.62659921
5MP0001968_abnormal_touch/_nociception3.52048144
6MP0003880_abnormal_central_pattern3.28851748
7MP0002822_catalepsy3.27240202
8MP0008057_abnormal_DNA_replication3.21290333
9MP0000569_abnormal_digit_pigmentation3.02294472
10MP0002063_abnormal_learning/memory/cond2.86505183
11MP0002735_abnormal_chemical_nociception2.81661365
12MP0004957_abnormal_blastocyst_morpholog2.78701229
13MP0009745_abnormal_behavioral_response2.75532085
14MP0002736_abnormal_nociception_after2.74822021
15MP0003787_abnormal_imprinting2.74554520
16MP0002734_abnormal_mechanical_nocicepti2.54881797
17MP0010094_abnormal_chromosome_stability2.46950593
18MP0003693_abnormal_embryo_hatching2.42722312
19MP0003221_abnormal_cardiomyocyte_apopto2.27627786
20MP0002733_abnormal_thermal_nociception2.20684843
21MP0002064_seizures2.20030410
22MP0010234_abnormal_vibrissa_follicle2.18241447
23MP0006072_abnormal_retinal_apoptosis2.17793744
24MP0002572_abnormal_emotion/affect_behav2.14545372
25MP0008058_abnormal_DNA_repair1.98967394
26MP0002272_abnormal_nervous_system1.97397562
27MP0004811_abnormal_neuron_physiology1.92437467
28MP0002909_abnormal_adrenal_gland1.88401169
29MP0003077_abnormal_cell_cycle1.88375140
30MP0001970_abnormal_pain_threshold1.87628949
31MP0008961_abnormal_basal_metabolism1.86177029
32MP0001486_abnormal_startle_reflex1.84924527
33MP0003111_abnormal_nucleus_morphology1.78473081
34MP0002184_abnormal_innervation1.76924925
35MP0009046_muscle_twitch1.76902428
36MP0005394_taste/olfaction_phenotype1.74151972
37MP0005499_abnormal_olfactory_system1.74151972
38MP0008932_abnormal_embryonic_tissue1.67807862
39MP0010678_abnormal_skin_adnexa1.65426275
40MP0006276_abnormal_autonomic_nervous1.63874843
41MP0002067_abnormal_sensory_capabilities1.61596851
42MP0001501_abnormal_sleep_pattern1.61500379
43MP0002090_abnormal_vision1.59423162
44MP0005085_abnormal_gallbladder_physiolo1.59194369
45MP0000955_abnormal_spinal_cord1.58732199
46MP0001440_abnormal_grooming_behavior1.56463962
47MP0005187_abnormal_penis_morphology1.55346116
48MP0002009_preneoplasia1.54356362
49MP0003941_abnormal_skin_development1.53146803
50MP0006035_abnormal_mitochondrial_morpho1.51448093
51MP0004858_abnormal_nervous_system1.50529901
52MP0008569_lethality_at_weaning1.49119629
53MP0008995_early_reproductive_senescence1.47561023
54MP0003252_abnormal_bile_duct1.47476639
55MP0000537_abnormal_urethra_morphology1.47251872
56MP0004924_abnormal_behavior1.46129878
57MP0005386_behavior/neurological_phenoty1.46129878
58MP0000778_abnormal_nervous_system1.44901664
59MP0003567_abnormal_fetal_cardiomyocyte1.44627697
60MP0004197_abnormal_fetal_growth/weight/1.43171426
61MP0003195_calcinosis1.42850174
62MP0002557_abnormal_social/conspecific_i1.41427980
63MP0005423_abnormal_somatic_nervous1.39049990
64MP0003123_paternal_imprinting1.35852803
65MP0001730_embryonic_growth_arrest1.34356375
66MP0001727_abnormal_embryo_implantation1.33637151
67MP0008007_abnormal_cellular_replicative1.32513997
68MP0009780_abnormal_chondrocyte_physiolo1.32421582
69MP0000647_abnormal_sebaceous_gland1.31949300
70MP0003786_premature_aging1.31602780
71MP0005365_abnormal_bile_salt1.30762641
72MP0003937_abnormal_limbs/digits/tail_de1.30035967
73MP0002877_abnormal_melanocyte_morpholog1.29390471
74MP0003183_abnormal_peptide_metabolism1.29146650
75MP0001764_abnormal_homeostasis1.28341357
76MP0008789_abnormal_olfactory_epithelium1.27698906
77MP0005253_abnormal_eye_physiology1.27550087
78MP0001293_anophthalmia1.27446360
79MP0002233_abnormal_nose_morphology1.23611809
80MP0001984_abnormal_olfaction1.23252684
81MP0004133_heterotaxia1.20630244
82MP0003718_maternal_effect1.19511948
83MP0002796_impaired_skin_barrier1.17989274
84MP0004885_abnormal_endolymph1.17006237
85MP0003329_amyloid_beta_deposits1.17002582
86MP0002882_abnormal_neuron_morphology1.16186378
87MP0010307_abnormal_tumor_latency1.15942548
88MP0009672_abnormal_birth_weight1.15753922
89MP0001672_abnormal_embryogenesis/_devel1.14164171
90MP0005380_embryogenesis_phenotype1.14164171
91MP0001697_abnormal_embryo_size1.13643669
92MP0003121_genomic_imprinting1.13480526
93MP0001188_hyperpigmentation1.12148378
94MP0002234_abnormal_pharynx_morphology1.10937690
95MP0001340_abnormal_eyelid_morphology1.10101194
96MP0003879_abnormal_hair_cell1.09346559
97MP0005391_vision/eye_phenotype1.09238390
98MP0002152_abnormal_brain_morphology1.07900385
99MP0002066_abnormal_motor_capabilities/c1.07586416
100MP0004233_abnormal_muscle_weight1.07429882
101MP0003868_abnormal_feces_composition1.06577994
102MP0001177_atelectasis1.06336469
103MP0002177_abnormal_outer_ear1.06244771
104MP0003315_abnormal_perineum_morphology1.05288750
105MP0005409_darkened_coat_color1.03977816
106MP0002092_abnormal_eye_morphology1.02258188
107MP0002697_abnormal_eye_size1.02064464
108MP0000350_abnormal_cell_proliferation1.00886791
109MP0003984_embryonic_growth_retardation1.00221547
110MP0008877_abnormal_DNA_methylation1.00022188
111MP0000358_abnormal_cell_content/0.99728385
112MP0002088_abnormal_embryonic_growth/wei0.97337427
113MP0004782_abnormal_surfactant_physiolog0.96917049
114MP0000372_irregular_coat_pigmentation0.95134176
115MP0001666_abnormal_nutrient_absorption0.94770125
116MP0005501_abnormal_skin_physiology0.93000245
117MP0000383_abnormal_hair_follicle0.91265341
118MP0003861_abnormal_nervous_system0.90449443
119MP0000516_abnormal_urinary_system0.89448495
120MP0005367_renal/urinary_system_phenotyp0.89448495
121MP0000566_synostosis0.87856412
122MP0002085_abnormal_embryonic_tissue0.87490519
123MP0000015_abnormal_ear_pigmentation0.87282329
124MP0002080_prenatal_lethality0.87183391
125MP0003300_gastrointestinal_ulcer0.86447670
126MP0009053_abnormal_anal_canal0.85807969
127MP0001529_abnormal_vocalization0.85549663
128MP0008874_decreased_physiological_sensi0.84623337
129MP0001286_abnormal_eye_development0.83948628
130MP0005408_hypopigmentation0.83550983
131MP0003943_abnormal_hepatobiliary_system0.81684607
132MP0002086_abnormal_extraembryonic_tissu0.81609077
133MP0004043_abnormal_pH_regulation0.80175608
134MP0000427_abnormal_hair_cycle0.79253566
135MP0005248_abnormal_Harderian_gland0.78919818
136MP0005379_endocrine/exocrine_gland_phen0.78854038
137MP0003633_abnormal_nervous_system0.78507857
138MP0003122_maternal_imprinting0.78475213
139MP0005646_abnormal_pituitary_gland0.78440961
140MP0001485_abnormal_pinna_reflex0.75504311
141MP0001299_abnormal_eye_distance/0.74840604
142MP0005174_abnormal_tail_pigmentation0.74622306
143MP0003045_fibrosis0.74308326
144MP0010352_gastrointestinal_tract_polyps0.74230287
145MP0002928_abnormal_bile_duct0.70884437
146MP0005645_abnormal_hypothalamus_physiol0.69674872
147MP0004264_abnormal_extraembryonic_tissu0.69203520
148MP0001664_abnormal_digestion0.67592223
149MP0003119_abnormal_digestive_system0.67582201
150MP0004085_abnormal_heartbeat0.67408607
151MP0002069_abnormal_eating/drinking_beha0.67003273
152MP0008872_abnormal_physiological_respon0.66687159
153MP0000534_abnormal_ureter_morphology0.66553504
154MP0003890_abnormal_embryonic-extraembry0.65904611
155MP0003631_nervous_system_phenotype0.65371789
156MP0008770_decreased_survivor_rate0.64282498
157MP0005076_abnormal_cell_differentiation0.61157988
158MP0002081_perinatal_lethality0.60336566
159MP0002229_neurodegeneration0.60189818
160MP0003705_abnormal_hypodermis_morpholog0.59602741
161MP0002751_abnormal_autonomic_nervous0.58619108
162MP0010769_abnormal_survival0.58383500
163MP0002082_postnatal_lethality0.58010584
164MP0010770_preweaning_lethality0.58010584
165MP0003283_abnormal_digestive_organ0.56598119
166MP0002084_abnormal_developmental_patter0.56397440
167MP0001502_abnormal_circadian_rhythm0.55667722
168MP0010768_mortality/aging0.55282651
169MP0000631_abnormal_neuroendocrine_gland0.54567724
170MP0009703_decreased_birth_body0.54366102
171MP0002139_abnormal_hepatobiliary_system0.53728932
172MP0003866_abnormal_defecation0.53121128

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.65785108
2Focal motor seizures (HP:0011153)5.26231334
3Focal seizures (HP:0007359)4.66641333
4Visual hallucinations (HP:0002367)4.13272022
5Papilledema (HP:0001085)4.11410162
6Ankyloglossia (HP:0010296)3.59967181
7Action tremor (HP:0002345)3.53455006
8Termporal pattern (HP:0011008)3.46233920
9Insidious onset (HP:0003587)3.46233920
10Abnormality of the lower motor neuron (HP:0002366)3.40783653
11Cortical dysplasia (HP:0002539)3.38436454
12Atonic seizures (HP:0010819)3.36939492
13Absence seizures (HP:0002121)3.33515654
14Papillary thyroid carcinoma (HP:0002895)3.25271602
15Febrile seizures (HP:0002373)3.22933966
16Urinary bladder sphincter dysfunction (HP:0002839)3.05088627
17Impaired vibration sensation in the lower limbs (HP:0002166)2.98360411
18Dysmetric saccades (HP:0000641)2.93558187
19Progressive cerebellar ataxia (HP:0002073)2.88132152
20Postnatal microcephaly (HP:0005484)2.87363881
21Thyroid carcinoma (HP:0002890)2.86402132
22Generalized tonic-clonic seizures (HP:0002069)2.85440775
23Dialeptic seizures (HP:0011146)2.84892930
24Vertebral arch anomaly (HP:0008438)2.84029186
25Annular pancreas (HP:0001734)2.83265558
26Pointed chin (HP:0000307)2.78613972
27Hyperglycinemia (HP:0002154)2.72448901
28Methylmalonic acidemia (HP:0002912)2.69724642
29Epileptic encephalopathy (HP:0200134)2.66556229
30Excessive salivation (HP:0003781)2.65795524
31Drooling (HP:0002307)2.65795524
32Abnormality of the vitamin B12 metabolism (HP:0004341)2.60230417
33Abnormality of oral frenula (HP:0000190)2.58217077
34Gaze-evoked nystagmus (HP:0000640)2.57391619
35Urinary urgency (HP:0000012)2.54508669
36Impaired social interactions (HP:0000735)2.53999292
37Abnormal social behavior (HP:0012433)2.53999292
38Poor eye contact (HP:0000817)2.51676762
39Impaired smooth pursuit (HP:0007772)2.50478049
40Broad-based gait (HP:0002136)2.49672107
41Curly hair (HP:0002212)2.47401666
42Volvulus (HP:0002580)2.45127289
43Ventricular fibrillation (HP:0001663)2.43622878
44Hypoglycemic coma (HP:0001325)2.42709350
45Insomnia (HP:0100785)2.42081028
46Truncal ataxia (HP:0002078)2.41865463
47Abnormality of vitamin B metabolism (HP:0004340)2.41770455
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40763539
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.40763539
50Dysdiadochokinesis (HP:0002075)2.39772157
51Supranuclear gaze palsy (HP:0000605)2.36660407
52Abnormality of methionine metabolism (HP:0010901)2.34469669
53Megaloblastic anemia (HP:0001889)2.34052785
54Bundle branch block (HP:0011710)2.33532570
55Congenital primary aphakia (HP:0007707)2.32924462
56Stereotypic behavior (HP:0000733)2.32769419
57Genetic anticipation (HP:0003743)2.30230160
58Abnormality of ocular smooth pursuit (HP:0000617)2.28856448
59Medulloblastoma (HP:0002885)2.28337800
60Multiple enchondromatosis (HP:0005701)2.27895374
61Depression (HP:0000716)2.27283277
62Decreased testicular size (HP:0008734)2.25947825
63Nephroblastoma (Wilms tumor) (HP:0002667)2.25630007
64Obsessive-compulsive behavior (HP:0000722)2.24952142
65Embryonal renal neoplasm (HP:0011794)2.23101048
66Gait imbalance (HP:0002141)2.22140398
67Macroorchidism (HP:0000053)2.19403788
68Scanning speech (HP:0002168)2.18268137
69Medial flaring of the eyebrow (HP:0010747)2.17479264
70Hypothermia (HP:0002045)2.16643677
71Obstructive sleep apnea (HP:0002870)2.16273470
72Pelvic girdle muscle weakness (HP:0003749)2.15401551
73Epidermoid cyst (HP:0200040)2.14703693
74Abnormal lung lobation (HP:0002101)2.14671860
75Proximal tubulopathy (HP:0000114)2.13963428
76Pheochromocytoma (HP:0002666)2.12516572
77Postural instability (HP:0002172)2.12412834
78Lower limb asymmetry (HP:0100559)2.12031753
79Hyperacusis (HP:0010780)2.09818880
80Hypobetalipoproteinemia (HP:0003563)2.09028358
81Upper limb muscle weakness (HP:0003484)2.08698852
82Tubulointerstitial nephritis (HP:0001970)2.07624765
83Resting tremor (HP:0002322)2.06622338
84Genital tract atresia (HP:0001827)2.05535674
85Dysmetria (HP:0001310)2.05325990
86Overlapping toe (HP:0001845)2.05117856
87Hypoglycemic seizures (HP:0002173)2.04924284
88Amyotrophic lateral sclerosis (HP:0007354)2.04680835
89Nephrogenic diabetes insipidus (HP:0009806)2.04474983
90Abnormality of the anterior horn cell (HP:0006802)2.03099874
91Degeneration of anterior horn cells (HP:0002398)2.03099874
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.02075465
93Ankle clonus (HP:0011448)2.01902687
94Amblyopia (HP:0000646)2.01889943
95Abnormality of serum amino acid levels (HP:0003112)2.01249986
96Vaginal atresia (HP:0000148)2.00921659
97Impaired vibratory sensation (HP:0002495)2.00893935
98Inappropriate behavior (HP:0000719)1.99895340
99Deep palmar crease (HP:0006191)1.98586206
100Abnormality of vitamin metabolism (HP:0100508)1.98503316
101Hepatoblastoma (HP:0002884)1.98205501
102Abnormality of the musculature of the pelvis (HP:0001469)1.98160637
103Abnormality of the hip-girdle musculature (HP:0001445)1.98160637
104Abnormality of glycine metabolism (HP:0010895)1.97837385
105Abnormality of serine family amino acid metabolism (HP:0010894)1.97837385
106Sacral dimple (HP:0000960)1.97782598
107Aqueductal stenosis (HP:0002410)1.97414010
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.96552543
109Mutism (HP:0002300)1.96149017
110Achilles tendon contracture (HP:0001771)1.95462311
111Impaired pain sensation (HP:0007328)1.94893100
112Abnormality of pain sensation (HP:0010832)1.94893100
113Broad alveolar ridges (HP:0000187)1.93752688
114Heterotopia (HP:0002282)1.93323431
115Shoulder girdle muscle weakness (HP:0003547)1.93203227
116Abnormality of the corticospinal tract (HP:0002492)1.92837882
117Spastic gait (HP:0002064)1.90261019
118Muscular hypotonia of the trunk (HP:0008936)1.89637817
119Anxiety (HP:0000739)1.88835744
120Facial hemangioma (HP:0000329)1.87180559
121Broad foot (HP:0001769)1.86549690
122Progressive external ophthalmoplegia (HP:0000590)1.85600474
123Attention deficit hyperactivity disorder (HP:0007018)1.85566444
124Breast carcinoma (HP:0003002)1.84819499
125Lower limb amyotrophy (HP:0007210)1.83815289
126Neuroendocrine neoplasm (HP:0100634)1.83733796
127Fair hair (HP:0002286)1.82881879
128Freckling (HP:0001480)1.82387390
129Prominent metopic ridge (HP:0005487)1.81804449
130Scrotal hypoplasia (HP:0000046)1.81360169
131Absent eyebrow (HP:0002223)1.81120059
132Morphological abnormality of the pyramidal tract (HP:0002062)1.80972502
133Abnormality of the Achilles tendon (HP:0005109)1.80812328
134Megalencephaly (HP:0001355)1.80767928
135Dry hair (HP:0011359)1.80647838
136Cutaneous finger syndactyly (HP:0010554)1.79821246
137Abnormal biliary tract morphology (HP:0012440)1.79330866
138Abnormality of the metopic suture (HP:0005556)1.78534132
139Atrioventricular block (HP:0001678)1.78154445
140Thoracolumbar scoliosis (HP:0002944)1.77391183
141Septate vagina (HP:0001153)1.76010167
142Asymmetry of the thorax (HP:0001555)1.75604952
143Enlarged penis (HP:0000040)1.75386201
144Postural tremor (HP:0002174)1.74590073
145Poor coordination (HP:0002370)1.73618425
146Menstrual irregularities (HP:0000858)1.73022178
147Gonadotropin excess (HP:0000837)1.72862997
148Bradykinesia (HP:0002067)1.72852541
149Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72175740
150Abnormality of the fingertips (HP:0001211)1.72049383
151Delayed CNS myelination (HP:0002188)1.72007970
152Apathy (HP:0000741)1.70476442
153Microvesicular hepatic steatosis (HP:0001414)1.70010048
154Central scotoma (HP:0000603)1.69880160
155Symptomatic seizures (HP:0011145)1.69772511
156Bowel incontinence (HP:0002607)1.69368375
157Elfin facies (HP:0004428)1.69144974
158Truncal obesity (HP:0001956)1.68993234
159Horizontal nystagmus (HP:0000666)1.68562534
160Pancreatic islet-cell hyperplasia (HP:0004510)1.68020954
161Hyperinsulinemic hypoglycemia (HP:0000825)1.67581453
162Autism (HP:0000717)1.67368808
163Abnormal auditory evoked potentials (HP:0006958)1.66789922
164Torticollis (HP:0000473)1.66145512
165Biliary tract neoplasm (HP:0100574)1.66076170
166Brushfield spots (HP:0001088)1.65576148
167Status epilepticus (HP:0002133)1.65168281
168Rhabdomyosarcoma (HP:0002859)1.64971438
169Abnormality of salivation (HP:0100755)1.64886893
170Epiphyseal stippling (HP:0010655)1.64363236
171Progressive inability to walk (HP:0002505)1.64094137
172Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63424671
173Abnormal protein N-linked glycosylation (HP:0012347)1.63424671
174Abnormal protein glycosylation (HP:0012346)1.63424671
175Abnormal glycosylation (HP:0012345)1.63424671
176Autoamputation (HP:0001218)1.63352531
177Hyperventilation (HP:0002883)1.63258426
178Epileptiform EEG discharges (HP:0011182)1.63056730
179Diastasis recti (HP:0001540)1.62575216
180Intellectual disability, profound (HP:0002187)1.60182352
181Abnormal spermatogenesis (HP:0008669)1.59917419
182EEG with generalized epileptiform discharges (HP:0011198)1.59551860
183Ketoacidosis (HP:0001993)1.59426537
184Micropenis (HP:0000054)1.59339363
185Progressive sensorineural hearing impairment (HP:0000408)1.58925591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.18242169
2MAP3K94.17982332
3NTRK34.09371979
4SRPK14.05917370
5TRIM283.57639656
6ERBB33.49148406
7BCR3.38058911
8KSR23.22852373
9MAP3K42.81941039
10EIF2AK32.76777486
11MINK12.64691893
12MKNK12.64195203
13MKNK22.52080399
14MST42.31825163
15TSSK62.27884808
16MAP3K22.09977051
17MAP2K42.07903619
18RPS6KA42.03528643
19NTRK12.02559152
20LATS21.98731727
21RIPK41.98100499
22MARK11.96004824
23PAK61.95306208
24DAPK21.94669159
25EIF2AK11.94355259
26KSR11.92299822
27BRSK21.91083423
28PBK1.86629133
29SIK21.85701307
30RET1.80790173
31BUB11.80328438
32CAMKK11.74956861
33TTK1.72820819
34CCNB11.69178266
35MAP4K21.64910850
36EPHA31.64300181
37TAOK11.64293126
38PKN21.62176938
39WEE11.60576333
40PINK11.59222883
41PLK31.47674328
42CASK1.46201417
43SIK31.45998688
44MAP2K71.42109187
45PRKD31.38822084
46STK381.36686416
47MAP3K101.36526574
48CDK121.33819078
49MST1R1.33467132
50CDC71.32532473
51TRIB31.31667194
52MAP3K61.28651916
53WNK31.28539873
54ALK1.26797416
55MAP3K71.22578414
56DAPK11.22271618
57CDK51.21815895
58DYRK31.21161312
59PLK41.19080739
60LATS11.18859705
61LMTK21.17787003
62CSNK1G31.16950820
63RIPK11.15780321
64RAF11.15363434
65CSNK1G11.14709418
66GRK51.13564218
67STK31.13417375
68CSNK1A1L1.09405032
69MAP3K121.08541978
70TYRO31.06864409
71MAPK131.06665596
72TAF11.05815381
73FRK1.05459247
74STK38L1.05433022
75SCYL21.04500456
76ACVR1B1.04233664
77PNCK1.04064757
78NTRK21.03124561
79FES1.02815526
80NUAK11.00663144
81NEK10.96042405
82PLK10.94107360
83PLK20.88811935
84STK110.88435254
85EIF2AK20.86963570
86TNIK0.86190368
87MAP3K130.85669174
88PAK30.85112483
89FGFR10.84307065
90EEF2K0.80387451
91UHMK10.79935342
92CDK30.75580154
93GRK60.74475907
94SGK30.72421501
95MAP3K10.71993421
96PRKCG0.70795490
97MARK20.70539798
98YES10.69241746
99MAP2K10.68823003
100CSNK1G20.67950836
101NME10.67118032
102CDK140.67012690
103MAPK100.66117611
104CAMKK20.65371046
105SGK10.65290584
106PRKCE0.64221200
107ERBB40.64215677
108GRK10.64157022
109STK240.62974902
110PTK2B0.62736210
111STK390.62303994
112MET0.62144511
113SGK20.61743507
114CSNK1E0.61417806
115EPHA20.61173203
116BRD40.58117345
117MAP3K50.57491942
118CAMK1G0.57241520
119FER0.57160588
120DYRK1B0.56132393
121PDK10.56082307
122PASK0.55622119
123CDK180.55513443
124CDK150.54216678
125CDK60.54187355
126AURKB0.54038050
127CAMK10.53896189
128FGFR20.52998923
129ZAK0.52468720
130PDGFRA0.52420395
131RPS6KA30.50149803
132ATM0.49755336
133NEK20.49527382
134BRSK10.48780947
135PRKCH0.47692158
136PHKG10.47614539
137PHKG20.47614539
138DYRK1A0.46596068
139DMPK0.46366105
140CDC42BPA0.46178919
141CDK11A0.45515143
142HIPK20.45410009
143PDPK10.44555915
144CAMK2A0.44462396
145ATR0.42515181
146CHEK10.40445635
147SGK4940.40295200
148SGK2230.40295200
149WNK10.40238438
150VRK10.39540413
151ARAF0.39118017
152CAMK40.38719329
153PRKCZ0.38693665
154GSK3B0.36875739
155CLK10.36208887
156RPS6KB10.35508856
157AKT30.35253024
158CHEK20.34817134
159NME20.34673139
160EGFR0.34514679
161MAPK80.34040508
162PRKCB0.33735946
163BMPR20.33219054
164CSNK1D0.31242416
165CSNK2A10.30967542
166MAP3K140.29296339
167FGFR30.28890194
168CSNK2A20.27402817

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.92274731
2Non-homologous end-joining_Homo sapiens_hsa034503.18052323
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.98734060
4Long-term potentiation_Homo sapiens_hsa047202.82539799
5Olfactory transduction_Homo sapiens_hsa047402.71868564
6Nicotine addiction_Homo sapiens_hsa050332.51528891
7RNA transport_Homo sapiens_hsa030132.47751644
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46056198
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.30296169
10Selenocompound metabolism_Homo sapiens_hsa004502.25229053
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22418806
12Amphetamine addiction_Homo sapiens_hsa050312.17035104
13Steroid biosynthesis_Homo sapiens_hsa001002.14710901
14Circadian entrainment_Homo sapiens_hsa047132.12234373
15Spliceosome_Homo sapiens_hsa030402.10815026
16Dopaminergic synapse_Homo sapiens_hsa047282.10703891
17Synaptic vesicle cycle_Homo sapiens_hsa047212.08475823
18Glutamatergic synapse_Homo sapiens_hsa047242.05789028
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.97944554
20Salivary secretion_Homo sapiens_hsa049701.92559094
21Morphine addiction_Homo sapiens_hsa050321.91442288
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82337470
23GABAergic synapse_Homo sapiens_hsa047271.81972502
24Cholinergic synapse_Homo sapiens_hsa047251.80925924
25Propanoate metabolism_Homo sapiens_hsa006401.80017426
26Gastric acid secretion_Homo sapiens_hsa049711.79242106
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77835184
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76839516
29Insulin secretion_Homo sapiens_hsa049111.76417567
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.71819064
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69149991
32Mismatch repair_Homo sapiens_hsa034301.68548045
33Basal transcription factors_Homo sapiens_hsa030221.68136074
34Glioma_Homo sapiens_hsa052141.67889750
35Cell cycle_Homo sapiens_hsa041101.65792630
36GnRH signaling pathway_Homo sapiens_hsa049121.63582759
37Proteasome_Homo sapiens_hsa030501.63428325
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63213715
39RNA degradation_Homo sapiens_hsa030181.63165571
40Taste transduction_Homo sapiens_hsa047421.62955235
41Oxytocin signaling pathway_Homo sapiens_hsa049211.60649865
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59079951
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.58694189
44Long-term depression_Homo sapiens_hsa047301.58305611
45Renin secretion_Homo sapiens_hsa049241.56198854
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52813215
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46540930
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45837355
49Dorso-ventral axis formation_Homo sapiens_hsa043201.45192571
50Fatty acid biosynthesis_Homo sapiens_hsa000611.43388814
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42928849
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39993365
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38739367
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36326922
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35315002
56Cocaine addiction_Homo sapiens_hsa050301.34475692
57Oocyte meiosis_Homo sapiens_hsa041141.34254011
58Nucleotide excision repair_Homo sapiens_hsa034201.33916518
59Gap junction_Homo sapiens_hsa045401.33836551
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31701747
61Estrogen signaling pathway_Homo sapiens_hsa049151.30108960
62Peroxisome_Homo sapiens_hsa041461.29655151
63Nitrogen metabolism_Homo sapiens_hsa009101.29651511
64Sulfur metabolism_Homo sapiens_hsa009201.28792861
65Calcium signaling pathway_Homo sapiens_hsa040201.26747828
66mTOR signaling pathway_Homo sapiens_hsa041501.26082430
67DNA replication_Homo sapiens_hsa030301.25589985
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24207192
69Serotonergic synapse_Homo sapiens_hsa047261.23648705
70Non-small cell lung cancer_Homo sapiens_hsa052231.23483905
71Biosynthesis of amino acids_Homo sapiens_hsa012301.23408376
72Vitamin B6 metabolism_Homo sapiens_hsa007501.21446760
73Fanconi anemia pathway_Homo sapiens_hsa034601.21093619
74cAMP signaling pathway_Homo sapiens_hsa040241.20850086
75Type II diabetes mellitus_Homo sapiens_hsa049301.19901665
76VEGF signaling pathway_Homo sapiens_hsa043701.15400512
77ErbB signaling pathway_Homo sapiens_hsa040121.14897865
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14786656
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14672744
80Melanogenesis_Homo sapiens_hsa049161.13959249
81Neurotrophin signaling pathway_Homo sapiens_hsa047221.13696936
82Endometrial cancer_Homo sapiens_hsa052131.12357379
83Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10875291
84Butanoate metabolism_Homo sapiens_hsa006501.10730124
85Choline metabolism in cancer_Homo sapiens_hsa052311.10119661
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09286362
87cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08155840
88Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06055216
89Renin-angiotensin system_Homo sapiens_hsa046141.05237524
90Primary bile acid biosynthesis_Homo sapiens_hsa001201.03644698
91Pyruvate metabolism_Homo sapiens_hsa006200.99577519
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99318591
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.98262916
94Thyroid cancer_Homo sapiens_hsa052160.97737692
95Carbon metabolism_Homo sapiens_hsa012000.97144077
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97137440
97p53 signaling pathway_Homo sapiens_hsa041150.94096388
98Axon guidance_Homo sapiens_hsa043600.94087649
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93594898
100Sphingolipid metabolism_Homo sapiens_hsa006000.93542031
101Pancreatic secretion_Homo sapiens_hsa049720.93481397
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92838219
103Bile secretion_Homo sapiens_hsa049760.91340655
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.91244159
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90816942
106RNA polymerase_Homo sapiens_hsa030200.89677651
107Colorectal cancer_Homo sapiens_hsa052100.88512092
108Fatty acid metabolism_Homo sapiens_hsa012120.86467371
109Thyroid hormone synthesis_Homo sapiens_hsa049180.85865745
110Base excision repair_Homo sapiens_hsa034100.85537262
111N-Glycan biosynthesis_Homo sapiens_hsa005100.84872307
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84637915
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82470016
114Glucagon signaling pathway_Homo sapiens_hsa049220.81809647
115Alcoholism_Homo sapiens_hsa050340.81795860
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78574919
117Insulin signaling pathway_Homo sapiens_hsa049100.77839587
118MAPK signaling pathway_Homo sapiens_hsa040100.76748864
119Inositol phosphate metabolism_Homo sapiens_hsa005620.76335966
120Vitamin digestion and absorption_Homo sapiens_hsa049770.76278501
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75130467
122Starch and sucrose metabolism_Homo sapiens_hsa005000.73788123
123Purine metabolism_Homo sapiens_hsa002300.73228770
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.72223628
125Rap1 signaling pathway_Homo sapiens_hsa040150.71763120
126Arginine and proline metabolism_Homo sapiens_hsa003300.70798110
127Pyrimidine metabolism_Homo sapiens_hsa002400.69722877
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69081365
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67842995
130Circadian rhythm_Homo sapiens_hsa047100.67730199
131One carbon pool by folate_Homo sapiens_hsa006700.67716859
132Chronic myeloid leukemia_Homo sapiens_hsa052200.67536725
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67232580
134Wnt signaling pathway_Homo sapiens_hsa043100.62928800
135Fatty acid degradation_Homo sapiens_hsa000710.62473057
136Renal cell carcinoma_Homo sapiens_hsa052110.62057239
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61589092
138Fatty acid elongation_Homo sapiens_hsa000620.61493077
139Platelet activation_Homo sapiens_hsa046110.59465072
140FoxO signaling pathway_Homo sapiens_hsa040680.58732028
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.58513559
142Vibrio cholerae infection_Homo sapiens_hsa051100.58204348
143Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57239795
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.57184972
145Prolactin signaling pathway_Homo sapiens_hsa049170.54788756
146B cell receptor signaling pathway_Homo sapiens_hsa046620.54124670
147Ras signaling pathway_Homo sapiens_hsa040140.54103622
148beta-Alanine metabolism_Homo sapiens_hsa004100.53449815
149Legionellosis_Homo sapiens_hsa051340.52493123
150Histidine metabolism_Homo sapiens_hsa003400.52294294
151Folate biosynthesis_Homo sapiens_hsa007900.51771089
152Pancreatic cancer_Homo sapiens_hsa052120.51300663
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50355896
154Insulin resistance_Homo sapiens_hsa049310.48756872
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.47908157
156Metabolic pathways_Homo sapiens_hsa011000.46852046
157Galactose metabolism_Homo sapiens_hsa000520.44273248
158Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44247478
159Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44222469
160Endocytosis_Homo sapiens_hsa041440.42850143
161Dilated cardiomyopathy_Homo sapiens_hsa054140.41808185
162Proteoglycans in cancer_Homo sapiens_hsa052050.40962028
163Glutathione metabolism_Homo sapiens_hsa004800.39487728
164Shigellosis_Homo sapiens_hsa051310.39141072
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.37232621
166Hippo signaling pathway_Homo sapiens_hsa043900.37011684
167Cardiac muscle contraction_Homo sapiens_hsa042600.36262812
168Fat digestion and absorption_Homo sapiens_hsa049750.36177461
169Melanoma_Homo sapiens_hsa052180.35568273
170Ether lipid metabolism_Homo sapiens_hsa005650.35096683
171Adherens junction_Homo sapiens_hsa045200.35071795
172mRNA surveillance pathway_Homo sapiens_hsa030150.34729030
173AMPK signaling pathway_Homo sapiens_hsa041520.34581949
174Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34519190
175Retinol metabolism_Homo sapiens_hsa008300.34480935
176Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34082709
177TGF-beta signaling pathway_Homo sapiens_hsa043500.33278122
178Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32844008
179Bladder cancer_Homo sapiens_hsa052190.32618747
180Arginine biosynthesis_Homo sapiens_hsa002200.32127596
181Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32034003

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