AP1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.45517764
2Golgi transport vesicle coating (GO:0048200)4.91659261
3COPI coating of Golgi vesicle (GO:0048205)4.91659261
4negative regulation of erythrocyte differentiation (GO:0045647)4.91247408
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.77084740
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73289992
7dicarboxylic acid biosynthetic process (GO:0043650)4.64037215
8sodium ion export (GO:0071436)4.41337228
9positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.35146112
10protein localization to endosome (GO:0036010)4.24387595
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.04191846
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.00618780
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99426868
14locomotory exploration behavior (GO:0035641)3.99000184
15mannose metabolic process (GO:0006013)3.94125646
16synaptic vesicle exocytosis (GO:0016079)3.86870770
17glycosphingolipid catabolic process (GO:0046479)3.86138864
18regulation of synaptic vesicle exocytosis (GO:2000300)3.78661372
19regulation of ARF protein signal transduction (GO:0032012)3.77936068
20activation of protein kinase A activity (GO:0034199)3.76404468
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.73761051
22response to peptidoglycan (GO:0032494)3.68924118
23cellular potassium ion homeostasis (GO:0030007)3.61842091
24pinocytosis (GO:0006907)3.61745128
25epithelial cell differentiation involved in prostate gland development (GO:0060742)3.61611638
26cell communication by electrical coupling (GO:0010644)3.56868621
27cerebellar Purkinje cell layer development (GO:0021680)3.52395812
28neurotransmitter secretion (GO:0007269)3.51203106
29regulation of leukocyte degranulation (GO:0043300)3.48573915
30glutamate secretion (GO:0014047)3.47894627
31regulation of synaptic vesicle transport (GO:1902803)3.47270844
32glycolipid catabolic process (GO:0019377)3.44801822
33potassium ion import (GO:0010107)3.41146209
34regulation of synapse structural plasticity (GO:0051823)3.31141248
35positive regulation by symbiont of host defense response (GO:0052509)3.29704391
36modulation by symbiont of host defense response (GO:0052031)3.29704391
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29704391
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29704391
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.29704391
40modulation by symbiont of host immune response (GO:0052553)3.29704391
41regulation of clathrin-mediated endocytosis (GO:2000369)3.29601214
42regulation of mast cell degranulation (GO:0043304)3.26624080
43regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23494646
44kynurenine metabolic process (GO:0070189)3.23320607
45regulation of ARF GTPase activity (GO:0032312)3.18861327
46adenosine receptor signaling pathway (GO:0001973)3.18449275
47amino sugar catabolic process (GO:0046348)3.17020109
48positive regulation of leukocyte degranulation (GO:0043302)3.16611078
49positive regulation of Cdc42 GTPase activity (GO:0043089)3.15566670
50NIK/NF-kappaB signaling (GO:0038061)3.14914561
51positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.13309495
52cellular response to thyroid hormone stimulus (GO:0097067)3.12098738
53response to muramyl dipeptide (GO:0032495)3.11906662
54proline transport (GO:0015824)3.11306795
55activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.09927484
56vesicle coating (GO:0006901)3.08932987
57glycine transport (GO:0015816)3.03466995
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.01713098
59macroautophagy (GO:0016236)3.01361521
60alanine transport (GO:0032328)3.01281043
61regulation of interferon-beta biosynthetic process (GO:0045357)2.99664406
62neuromuscular process controlling posture (GO:0050884)2.98386063
63negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.96697844
64modulation by symbiont of host cellular process (GO:0044068)2.96364205
65ceramide catabolic process (GO:0046514)2.96229574
66regulation of superoxide anion generation (GO:0032928)2.95895628
67positive regulation of nuclease activity (GO:0032075)2.94003672
68positive regulation of synapse maturation (GO:0090129)2.93726903
69L-alpha-amino acid transmembrane transport (GO:1902475)2.93485386
70pentose-phosphate shunt (GO:0006098)2.92976171
71N-acetylneuraminate metabolic process (GO:0006054)2.90733729
72signal complex assembly (GO:0007172)2.89724597
73synaptic vesicle endocytosis (GO:0048488)2.89501865
74neutrophil activation involved in immune response (GO:0002283)2.86500767
75positive regulation of gamma-delta T cell activation (GO:0046645)2.85704115
76immunoglobulin mediated immune response (GO:0016064)2.85110388
77negative regulation of cell killing (GO:0031342)2.85037693
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.85037693
79layer formation in cerebral cortex (GO:0021819)2.84431207
80negative regulation of granulocyte differentiation (GO:0030853)2.84421350
81regulation of neuronal synaptic plasticity (GO:0048168)2.83777141
82response to thyroid hormone (GO:0097066)2.83155112
83regulation of mast cell activation involved in immune response (GO:0033006)2.79970996
84adhesion of symbiont to host (GO:0044406)2.79505852
85regulation of regulated secretory pathway (GO:1903305)2.78164616
86positive regulation of mast cell activation involved in immune response (GO:0033008)2.77136678
87positive regulation of mast cell degranulation (GO:0043306)2.77136678
88apoptotic process involved in morphogenesis (GO:0060561)2.76967611
89sexual reproduction (GO:0019953)2.76144211
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.74952795
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74364479
92* antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.74083171
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.72088089
94* antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)2.70657915
95* antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002502.70657915
96modulation by virus of host process (GO:0019054)2.70349668
97clathrin coat assembly (GO:0048268)2.69774910
98stress fiber assembly (GO:0043149)2.68171834
99vocalization behavior (GO:0071625)2.68101837
100regulation of glutamate receptor signaling pathway (GO:1900449)2.67574299
101cellular sodium ion homeostasis (GO:0006883)2.66565803
102positive regulation of histone deacetylation (GO:0031065)2.65866827
103response to laminar fluid shear stress (GO:0034616)2.65005283
104positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.64362602
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63271277
106lysine metabolic process (GO:0006553)2.61597291
107lysine catabolic process (GO:0006554)2.61597291
108positive regulation of receptor recycling (GO:0001921)2.61460655
109cell communication involved in cardiac conduction (GO:0086065)2.60931595
110regulation of nuclease activity (GO:0032069)2.60719514
111regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.59767910
112adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59671850
113oxaloacetate metabolic process (GO:0006107)2.58760613
114negative regulation of interleukin-12 production (GO:0032695)2.58493756
115response to pheromone (GO:0019236)2.58261738
116activation of Rac GTPase activity (GO:0032863)2.57506125
117dopamine receptor signaling pathway (GO:0007212)2.57402229
118apoptotic cell clearance (GO:0043277)2.57330622
119regulation of early endosome to late endosome transport (GO:2000641)2.56884220
120germinal center formation (GO:0002467)2.56838269
121endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.56264520
122fatty acid homeostasis (GO:0055089)2.56179547
123adhesion of symbiont to host cell (GO:0044650)2.56141210
124virion attachment to host cell (GO:0019062)2.56141210
125neurotransmitter-gated ion channel clustering (GO:0072578)2.55363214
126glucose 6-phosphate metabolic process (GO:0051156)2.54798163
127proline biosynthetic process (GO:0006561)2.54691453
128cell-cell junction maintenance (GO:0045217)2.53169343
129amyloid precursor protein catabolic process (GO:0042987)2.52891570
130axon cargo transport (GO:0008088)2.52641419
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51679431
132response to acidic pH (GO:0010447)2.51559584
133regulation of cholesterol storage (GO:0010885)2.51448610
134NADPH regeneration (GO:0006740)2.49200696
135membrane repolarization (GO:0086009)2.47858000
136oligosaccharide catabolic process (GO:0009313)2.47848409
137protein retention in ER lumen (GO:0006621)2.46847102
138neuromuscular process controlling balance (GO:0050885)2.46845688
139cellular response to electrical stimulus (GO:0071257)2.46208283
140sphingolipid catabolic process (GO:0030149)2.46126938
141exploration behavior (GO:0035640)2.45765116
142negative regulation of cell size (GO:0045792)2.45390379
143neurotransmitter transport (GO:0006836)2.45363992
144peptide catabolic process (GO:0043171)2.44977642
145membrane lipid catabolic process (GO:0046466)2.44885572
146activation of MAPKKK activity (GO:0000185)2.44607686
147negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44539777
148* regulation of defense response to virus by virus (GO:0050690)2.44213441
149actin filament capping (GO:0051693)2.44176115
150positive regulation of exocytosis (GO:0045921)2.44111019
151semaphorin-plexin signaling pathway (GO:0071526)2.44081576
152regulation of NFAT protein import into nucleus (GO:0051532)2.43745949
153glucose catabolic process (GO:0006007)2.42819015
154cellular response to exogenous dsRNA (GO:0071360)2.42741410
155positive regulation of regulated secretory pathway (GO:1903307)2.42614385
156establishment of nucleus localization (GO:0040023)2.42270455
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.42102336
158positive regulation of cellular amide metabolic process (GO:0034250)2.41933568
159indole-containing compound catabolic process (GO:0042436)2.41820452
160indolalkylamine catabolic process (GO:0046218)2.41820452
161tryptophan catabolic process (GO:0006569)2.41820452
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41685192
163adaptation of signaling pathway (GO:0023058)2.40657342
164NADH metabolic process (GO:0006734)2.40466030
165endoplasmic reticulum unfolded protein response (GO:0030968)2.40370079
166positive regulation of mast cell activation (GO:0033005)2.39938270
167detection of other organism (GO:0098543)2.39450696
168potassium ion homeostasis (GO:0055075)2.38758940
169positive thymic T cell selection (GO:0045059)2.38012526
170modulation by virus of host morphology or physiology (GO:0019048)2.37412447
171regulation of T-helper 2 cell differentiation (GO:0045628)2.36922311
172B cell receptor signaling pathway (GO:0050853)2.36238331
173macrophage activation involved in immune response (GO:0002281)2.36055168
174barbed-end actin filament capping (GO:0051016)2.35308041
175G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.34903619
176intracellular estrogen receptor signaling pathway (GO:0030520)2.34457591
177membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34048289
178cortical actin cytoskeleton organization (GO:0030866)2.33259463
179regulation of MHC class II biosynthetic process (GO:0045346)2.33129993
180adherens junction assembly (GO:0034333)2.32566140
181positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32466987
182regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32077097
183low-density lipoprotein particle clearance (GO:0034383)2.31962489
184positive regulation of B cell differentiation (GO:0045579)2.31662547
185regulation of cholesterol homeostasis (GO:2000188)2.31444139
186regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31429854
187cellular response to glucagon stimulus (GO:0071377)2.30944505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.09111109
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.70276322
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.63732088
4* LXR_22292898_ChIP-Seq_THP-1_Human2.61138793
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.49645155
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41873181
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33443714
8GATA1_22025678_ChIP-Seq_K562_Human2.31105163
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.28248209
10KDM2B_26808549_Chip-Seq_DND41_Human2.24575652
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20343681
12GATA1_19941827_ChIP-Seq_MEL_Mouse2.19483213
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13394952
14DROSHA_22980978_ChIP-Seq_HELA_Human2.10691783
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05483233
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01257016
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99933220
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.97317497
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.97043783
20EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.95905281
21SPI1_23127762_ChIP-Seq_K562_Human1.95210430
22TCF7_22412390_ChIP-Seq_EML_Mouse1.94659204
23VDR_21846776_ChIP-Seq_THP-1_Human1.94628198
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90660332
25KDM2B_26808549_Chip-Seq_K562_Human1.89099269
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88022956
27GATA1_19941826_ChIP-Seq_K562_Human1.85902013
28GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.83937927
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83681693
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83198005
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.79732137
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79578880
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79303701
34P68_20966046_ChIP-Seq_HELA_Human1.76216080
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73494009
36* REST_18959480_ChIP-ChIP_MESCs_Mouse1.70052310
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69772463
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.69389209
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.63238572
40SMC4_20622854_ChIP-Seq_HELA_Human1.57069279
41* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.55336008
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.53648994
43ZNF263_19887448_ChIP-Seq_K562_Human1.53311657
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.52794037
45* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52190561
46TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.52082653
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51406577
48* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50300972
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48742309
50UTX_26944678_Chip-Seq_JUKART_Human1.47687802
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.47630439
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.44380659
53REST_21632747_ChIP-Seq_MESCs_Mouse1.44345648
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.43823447
55MAF_26560356_Chip-Seq_TH1_Human1.43445791
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.42990773
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42890179
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42534259
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40445254
60BCL6_27268052_Chip-Seq_Bcells_Human1.38757708
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.38319130
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37742712
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37220829
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36702494
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.36080968
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35729472
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34181355
68BCOR_27268052_Chip-Seq_Bcells_Human1.33705015
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.33491266
70* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31949394
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.31087598
72IRF8_22096565_ChIP-ChIP_GC-B_Human1.30457560
73PHF8_20622854_ChIP-Seq_HELA_Human1.29909099
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29539608
75CLOCK_20551151_ChIP-Seq_293T_Human1.28506405
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28029442
77MAF_26560356_Chip-Seq_TH2_Human1.27708923
78* TET1_21451524_ChIP-Seq_MESCs_Mouse1.27219995
79* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26498080
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26305425
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26147625
82CREB1_26743006_Chip-Seq_LNCaP_Human1.25672633
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24696041
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23912970
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23810517
86NCOR1_26117541_ChIP-Seq_K562_Human1.23186868
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23098443
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21867112
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20211958
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19440814
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.19065569
92* SPI1_20517297_ChIP-Seq_HL60_Human1.18739174
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18560308
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17435922
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17371586
96GATA2_19941826_ChIP-Seq_K562_Human1.16937642
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16047226
98* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16044388
99* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15734288
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14584144
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14551955
102VDR_24763502_ChIP-Seq_THP-1_Human1.14195513
103CTCF_27219007_Chip-Seq_Bcells_Human1.13763789
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13688230
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12703839
106* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12653257
107CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12601037
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11321413
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10326112
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10218156
111SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09207024
112LXR_22158963_ChIP-Seq_LIVER_Mouse1.08558068
113* E2F1_20622854_ChIP-Seq_HELA_Human1.07816052
114* SPI1_23547873_ChIP-Seq_NB4_Human1.07543398
115TP53_22127205_ChIP-Seq_IMR90_Human1.06488335
116STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05958179
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05575181
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05048291
119RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04256864
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04076293
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02491274
122* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02483331
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02283698
124ATF3_27146783_Chip-Seq_COLON_Human1.02111446
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01887919
126BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01387542
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01304015
128HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.01216072
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00968083
130* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00873767
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00238490
132IRF8_27001747_Chip-Seq_BMDM_Mouse0.99707375
133CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99633544
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.98829154
135GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96579513
136OCT4_19829295_ChIP-Seq_ESCs_Human0.96571810
137SCL_19346495_ChIP-Seq_HPC-7_Human0.95985829
138SA1_27219007_Chip-Seq_Bcells_Human0.95739591
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95560265
140RUNX_20019798_ChIP-Seq_JUKART_Human0.95475540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.33360131
2MP0005058_abnormal_lysosome_morphology4.11337562
3MP0002909_abnormal_adrenal_gland3.01469409
4MP0003172_abnormal_lysosome_physiology2.94690180
5MP0005451_abnormal_body_composition2.81718002
6MP0008961_abnormal_basal_metabolism2.71694534
7MP0003283_abnormal_digestive_organ2.46278875
8MP0004510_myositis2.44150339
9MP0003300_gastrointestinal_ulcer2.38359531
10MP0008260_abnormal_autophagy2.35313484
11MP0009840_abnormal_foam_cell2.32125112
12MP0009278_abnormal_bone_marrow2.27734403
13MP0003635_abnormal_synaptic_transmissio2.25294224
14MP0003656_abnormal_erythrocyte_physiolo2.23339034
15MP0009780_abnormal_chondrocyte_physiolo2.21280894
16MP0001849_ear_inflammation2.21105572
17MP0000013_abnormal_adipose_tissue2.13398448
18MP0002822_catalepsy2.12887300
19MP0000604_amyloidosis1.99670776
20MP0003453_abnormal_keratinocyte_physiol1.95078101
21MP0002419_abnormal_innate_immunity1.89042029
22MP0004947_skin_inflammation1.88755124
23MP0003329_amyloid_beta_deposits1.86841651
24MP0000685_abnormal_immune_system1.85082789
25MP0000569_abnormal_digit_pigmentation1.84226111
26MP0003566_abnormal_cell_adhesion1.82385428
27MP0003011_delayed_dark_adaptation1.77541802
28MP0005025_abnormal_response_to1.68817264
29MP0005000_abnormal_immune_tolerance1.67198381
30MP0003183_abnormal_peptide_metabolism1.67012569
31MP0004147_increased_porphyrin_level1.64562027
32MP0002064_seizures1.64023558
33MP0002063_abnormal_learning/memory/cond1.60405816
34MP0003303_peritoneal_inflammation1.59687565
35MP0000858_altered_metastatic_potential1.57502911
36MP0000343_altered_response_to1.54605441
37MP0003191_abnormal_cellular_cholesterol1.54350030
38MP0005310_abnormal_salivary_gland1.52520726
39MP0004858_abnormal_nervous_system1.52234043
40MP0002452_abnormal_antigen_presenting1.51679458
41MP0003075_altered_response_to1.51271340
42MP0003091_abnormal_cell_migration1.49792777
43MP0002148_abnormal_hypersensitivity_rea1.47808292
44MP0004270_analgesia1.46925169
45MP0001835_abnormal_antigen_presentation1.46679264
46MP0009333_abnormal_splenocyte_physiolog1.44904758
47MP0002796_impaired_skin_barrier1.41488624
48MP0004043_abnormal_pH_regulation1.40981921
49MP0005409_darkened_coat_color1.39860761
50MP0004185_abnormal_adipocyte_glucose1.37293805
51MP0006082_CNS_inflammation1.37103822
52MP0001545_abnormal_hematopoietic_system1.35861122
53MP0005397_hematopoietic_system_phenotyp1.35861122
54MP0002723_abnormal_immune_serum1.35286590
55MP0004264_abnormal_extraembryonic_tissu1.35135085
56MP0001533_abnormal_skeleton_physiology1.34928880
57MP0002998_abnormal_bone_remodeling1.34793605
58MP0009745_abnormal_behavioral_response1.34450928
59MP0001800_abnormal_humoral_immune1.33005030
60MP0001853_heart_inflammation1.31388739
61MP0005671_abnormal_response_to1.31090439
62MP0001819_abnormal_immune_cell1.30540612
63MP0004130_abnormal_muscle_cell1.30285437
64MP0002420_abnormal_adaptive_immunity1.30241341
65MP0005365_abnormal_bile_salt1.29986397
66MP0002090_abnormal_vision1.29380452
67MP0003879_abnormal_hair_cell1.28962923
68MP0010155_abnormal_intestine_physiology1.28858378
69MP0000465_gastrointestinal_hemorrhage1.28588056
70MP0010329_abnormal_lipoprotein_level1.26676010
71MP0001756_abnormal_urination1.23667430
72MP0002078_abnormal_glucose_homeostasis1.23486674
73MP0004811_abnormal_neuron_physiology1.23140961
74MP0001968_abnormal_touch/_nociception1.21898252
75MP0008569_lethality_at_weaning1.21637810
76MP0002693_abnormal_pancreas_physiology1.19264683
77MP0005360_urolithiasis1.19010530
78MP0005551_abnormal_eye_electrophysiolog1.18620721
79MP0003633_abnormal_nervous_system1.18080116
80MP0000490_abnormal_crypts_of1.17843016
81MP0000003_abnormal_adipose_tissue1.16006573
82MP0005464_abnormal_platelet_physiology1.15760397
83MP0002837_dystrophic_cardiac_calcinosis1.15171752
84MP0000678_abnormal_parathyroid_gland1.15044517
85MP0003866_abnormal_defecation1.15011916
86MP0003828_pulmonary_edema1.11537650
87MP0006054_spinal_hemorrhage1.10488518
88MP0009046_muscle_twitch1.10439783
89MP0009785_altered_susceptibility_to1.10137462
90MP0002877_abnormal_melanocyte_morpholog1.09852308
91MP0002572_abnormal_emotion/affect_behav1.08065088
92MP0001845_abnormal_inflammatory_respons1.07417592
93MP0002398_abnormal_bone_marrow1.07296607
94MP0005535_abnormal_body_temperature1.07124641
95MP0010234_abnormal_vibrissa_follicle1.07029842
96MP0005501_abnormal_skin_physiology1.05442765
97MP0000716_abnormal_immune_system1.04350391
98MP0002733_abnormal_thermal_nociception1.04236459
99MP0010386_abnormal_urinary_bladder1.03725684
100MP0005666_abnormal_adipose_tissue1.01135247
101MP0003763_abnormal_thymus_physiology1.00993425
102MP0002405_respiratory_system_inflammati1.00960653
103MP0008004_abnormal_stomach_pH1.00952321
104MP0005670_abnormal_white_adipose0.98872398
105MP0004019_abnormal_vitamin_homeostasis0.98723347
106MP0005076_abnormal_cell_differentiation0.98439817
107MP0004808_abnormal_hematopoietic_stem0.98044884
108MP0003279_aneurysm0.97851903
109MP0009643_abnormal_urine_homeostasis0.97747806
110MP0002229_neurodegeneration0.97308358
111MP0002429_abnormal_blood_cell0.96551160
112MP0008469_abnormal_protein_level0.96117805
113MP0000751_myopathy0.95780635
114MP0002736_abnormal_nociception_after0.95005073
115MP0003634_abnormal_glial_cell0.94671517
116MP0004885_abnormal_endolymph0.93034361
117MP0000609_abnormal_liver_physiology0.93018039
118MP0003448_altered_tumor_morphology0.92444319
119MP0005166_decreased_susceptibility_to0.92136061
120MP0002734_abnormal_mechanical_nocicepti0.90792214
121MP0005584_abnormal_enzyme/coenzyme_acti0.90071326
122MP0001348_abnormal_lacrimal_gland0.88162390
123MP0002722_abnormal_immune_system0.88007162
124MP0001970_abnormal_pain_threshold0.87855408
125MP0005023_abnormal_wound_healing0.87204320
126MP0000689_abnormal_spleen_morphology0.86786093
127MP0005621_abnormal_cell_physiology0.86641588
128MP0005375_adipose_tissue_phenotype0.86457109
129MP0002139_abnormal_hepatobiliary_system0.86028299
130MP0001666_abnormal_nutrient_absorption0.85777568
131MP0000747_muscle_weakness0.85361591
132MP0003436_decreased_susceptibility_to0.84754653
133MP0001765_abnormal_ion_homeostasis0.84296926
134MP0001216_abnormal_epidermal_layer0.83949475
135MP0010352_gastrointestinal_tract_polyps0.83373571
136MP0001944_abnormal_pancreas_morphology0.83347961
137MP0005083_abnormal_biliary_tract0.83244636
138MP0002396_abnormal_hematopoietic_system0.81048978
139MP0008872_abnormal_physiological_respon0.80205106
140MP0003045_fibrosis0.79600166
141MP0001915_intracranial_hemorrhage0.78749701
142MP0003724_increased_susceptibility_to0.78736503
143MP0003705_abnormal_hypodermis_morpholog0.78180837
144MP0005165_increased_susceptibility_to0.78087379
145MP0008874_decreased_physiological_sensi0.77933151
146MP0005257_abnormal_intraocular_pressure0.77911840
147MP0002272_abnormal_nervous_system0.77639834
148MP0004233_abnormal_muscle_weight0.77122465
149MP0005167_abnormal_blood-brain_barrier0.76540534
150MP0000920_abnormal_myelination0.76015950
151MP0002067_abnormal_sensory_capabilities0.75887855
152MP0001502_abnormal_circadian_rhythm0.75342799
153MP0001873_stomach_inflammation0.75059786
154MP0003631_nervous_system_phenotype0.74666241
155MP0002653_abnormal_ependyma_morphology0.74334644
156MP0002269_muscular_atrophy0.73530092
157MP0009931_abnormal_skin_appearance0.73156337
158MP0004381_abnormal_hair_follicle0.72432578
159MP0010307_abnormal_tumor_latency0.72337329
160MP0002234_abnormal_pharynx_morphology0.71664329
161MP0002089_abnormal_postnatal_growth/wei0.71646796
162MP0002069_abnormal_eating/drinking_beha0.70647497
163MP0002118_abnormal_lipid_homeostasis0.70484085
164MP0005646_abnormal_pituitary_gland0.69442744
165MP0005448_abnormal_energy_balance0.68125040
166MP0001790_abnormal_immune_system0.67891603
167MP0005387_immune_system_phenotype0.67891603
168MP0002138_abnormal_hepatobiliary_system0.66660981
169MP0005423_abnormal_somatic_nervous0.65826916
170MP0003690_abnormal_glial_cell0.65620906

Predicted human phenotypes

RankGene SetZ-score
1Visual hallucinations (HP:0002367)4.09227666
2Increased cerebral lipofuscin (HP:0011813)3.93348996
3Dysostosis multiplex (HP:0000943)3.85887360
4Urinary glycosaminoglycan excretion (HP:0003541)3.43667832
5Mucopolysacchariduria (HP:0008155)3.43667832
6Abnormality of mucopolysaccharide metabolism (HP:0011020)3.30762791
7Abnormality of polysaccharide metabolism (HP:0011012)3.30762791
8Abnormality of glycosaminoglycan metabolism (HP:0004371)3.30762791
9Myokymia (HP:0002411)3.25934651
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.13710769
11Axonal loss (HP:0003447)3.09459702
12Abnormality of macrophages (HP:0004311)3.00120780
13Supranuclear gaze palsy (HP:0000605)2.91653347
14Global brain atrophy (HP:0002283)2.90691265
15Abnormal delayed hypersensitivity skin test (HP:0002963)2.89653555
16Bundle branch block (HP:0011710)2.89433849
17Eczematoid dermatitis (HP:0000976)2.88297573
18Depression (HP:0000716)2.85946666
19Asymmetric septal hypertrophy (HP:0001670)2.85046600
20Recurrent abscess formation (HP:0002722)2.84551825
21Cellulitis (HP:0100658)2.84489957
22Colitis (HP:0002583)2.82817732
23Recurrent bacterial skin infections (HP:0005406)2.82097840
24Upper motor neuron abnormality (HP:0002127)2.79591966
25Insomnia (HP:0100785)2.75456735
26Vertebral compression fractures (HP:0002953)2.68687724
27Abnormality of the lower motor neuron (HP:0002366)2.67136386
28Ventricular fibrillation (HP:0001663)2.66361376
29Spontaneous hematomas (HP:0007420)2.63033843
30Papilledema (HP:0001085)2.62521918
31Central scotoma (HP:0000603)2.53546466
32Systemic lupus erythematosus (HP:0002725)2.52687185
33Failure to thrive in infancy (HP:0001531)2.52133894
34Panhypogammaglobulinemia (HP:0003139)2.48328771
35Neurofibrillary tangles (HP:0002185)2.46829051
36Distal lower limb amyotrophy (HP:0008944)2.46000402
37Postural instability (HP:0002172)2.45915365
38Thoracic kyphosis (HP:0002942)2.44880744
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.42781213
40Nuclear cataract (HP:0100018)2.42438542
41Hand muscle atrophy (HP:0009130)2.40569392
42Focal seizures (HP:0007359)2.38737595
43Glomerulonephritis (HP:0000099)2.38538548
44Impaired smooth pursuit (HP:0007772)2.38369161
45Thin bony cortex (HP:0002753)2.37780415
46Hyperacusis (HP:0010780)2.37646933
47Mutism (HP:0002300)2.35273241
48Abnormality of the thoracic spine (HP:0100711)2.30410755
49Apathy (HP:0000741)2.29390857
50Purpura (HP:0000979)2.28312446
51Personality changes (HP:0000751)2.27890438
52Achilles tendon contracture (HP:0001771)2.27730107
53Neuronal loss in central nervous system (HP:0002529)2.27566871
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25270568
55J-shaped sella turcica (HP:0002680)2.25209887
56Ankle clonus (HP:0011448)2.24491357
57Centrally nucleated skeletal muscle fibers (HP:0003687)2.23419322
58Hemiplegia (HP:0002301)2.22490628
59Gastrointestinal inflammation (HP:0004386)2.19485287
60Agitation (HP:0000713)2.18500419
61Distal lower limb muscle weakness (HP:0009053)2.16798502
62Retinal atrophy (HP:0001105)2.16710908
63Mediastinal lymphadenopathy (HP:0100721)2.16395315
64Abnormality of ocular smooth pursuit (HP:0000617)2.16220360
65Dysmetric saccades (HP:0000641)2.16049481
66Ketoacidosis (HP:0001993)2.15222097
67Upper limb amyotrophy (HP:0009129)2.14539772
68Distal upper limb amyotrophy (HP:0007149)2.14539772
69Hypercortisolism (HP:0001578)2.14346887
70Inflammation of the large intestine (HP:0002037)2.13739553
71Cerebral aneurysm (HP:0004944)2.12714975
72Action tremor (HP:0002345)2.11226174
73Focal motor seizures (HP:0011153)2.11213151
74Long toe (HP:0010511)2.10100788
75Late onset (HP:0003584)2.09733257
76Abnormality of glycolipid metabolism (HP:0010969)2.09658590
77Abnormality of liposaccharide metabolism (HP:0010968)2.09658590
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.09658590
79Chronic obstructive pulmonary disease (HP:0006510)2.08971070
80Obstructive lung disease (HP:0006536)2.08971070
81Bone pain (HP:0002653)2.07684943
82Hemorrhage of the eye (HP:0011885)2.07483797
83Disinhibition (HP:0000734)2.07366458
84Oligomenorrhea (HP:0000876)2.06962960
85Myocardial infarction (HP:0001658)2.06510400
86Pathologic fracture (HP:0002756)2.06280560
87Abnormality of the Achilles tendon (HP:0005109)2.03288382
88Large eyes (HP:0001090)2.02304009
89Gingivitis (HP:0000230)2.01586022
90Hyperparathyroidism (HP:0000843)1.99723926
91Status epilepticus (HP:0002133)1.98673817
92Bony spicule pigmentary retinopathy (HP:0007737)1.98054784
93Cholelithiasis (HP:0001081)1.97865054
94Gastrointestinal stroma tumor (HP:0100723)1.97570586
95Recurrent viral infections (HP:0004429)1.97495636
96Generalized hyperpigmentation (HP:0007440)1.96035564
97Posterior subcapsular cataract (HP:0007787)1.95187139
98Pointed chin (HP:0000307)1.94997784
99Complement deficiency (HP:0004431)1.94600743
100Agammaglobulinemia (HP:0004432)1.90376199
101Absence seizures (HP:0002121)1.89200691
102Loss of speech (HP:0002371)1.88712459
103Cholecystitis (HP:0001082)1.87862423
104Abnormal gallbladder physiology (HP:0012438)1.87862423
105Vacuolated lymphocytes (HP:0001922)1.87667271
106EMG: neuropathic changes (HP:0003445)1.86827071
107Cerebral inclusion bodies (HP:0100314)1.86589550
108Congenital stationary night blindness (HP:0007642)1.86346459
109Poikilocytosis (HP:0004447)1.86202666
110Hypertensive crisis (HP:0100735)1.86173866
111Flat acetabular roof (HP:0003180)1.85565192
112Petechiae (HP:0000967)1.84974311
113Generalized tonic-clonic seizures (HP:0002069)1.84293645
114Deep palmar crease (HP:0006191)1.83796031
115Sensorimotor neuropathy (HP:0007141)1.82422766
116Reticulocytosis (HP:0001923)1.82030040
117Broad face (HP:0000283)1.81992293
118Interstitial pulmonary disease (HP:0006530)1.81416500
119Growth hormone excess (HP:0000845)1.81387301
120Striae distensae (HP:0001065)1.80949458
121Abnormal social behavior (HP:0012433)1.80415898
122Impaired social interactions (HP:0000735)1.80415898
123Hyperuricemia (HP:0002149)1.80341841
124Increased purine levels (HP:0004368)1.80341841
125Increased serum ferritin (HP:0003281)1.80194914
126Obstructive sleep apnea (HP:0002870)1.80124545
127Increased IgE level (HP:0003212)1.80060899
128Cardiomegaly (HP:0001640)1.79802136
129Hepatosplenomegaly (HP:0001433)1.79185910
130Increased connective tissue (HP:0009025)1.78711948
131Scotoma (HP:0000575)1.78406291
132Progressive neurologic deterioration (HP:0002344)1.77667463
133Hypoglycemic coma (HP:0001325)1.77091144
134Rapidly progressive (HP:0003678)1.75535512
135Villous atrophy (HP:0011473)1.75065852
136Abnormality of small intestinal villus morphology (HP:0011472)1.75065852
137Viral hepatitis (HP:0006562)1.74526498
138Abnormal gallbladder morphology (HP:0012437)1.74494804
139Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74309032
140Resting tremor (HP:0002322)1.74229362
141Alkalosis (HP:0001948)1.74075735
142Meningitis (HP:0001287)1.73980201
143Dementia (HP:0000726)1.73805146
144Hypoglycemic seizures (HP:0002173)1.73078733
145Recurrent gram-negative bacterial infections (HP:0005420)1.72048610
146Amyloidosis (HP:0011034)1.71174429
147Esophageal varix (HP:0002040)1.70650877
148Abnormal eating behavior (HP:0100738)1.70497955
149Increased CSF protein (HP:0002922)1.69901047
150Abnormality of complement system (HP:0005339)1.69143523
151Diminished motivation (HP:0000745)1.69080369
152Polycythemia (HP:0001901)1.68456282
153Polygenic inheritance (HP:0010982)1.68168898
154Prolonged neonatal jaundice (HP:0006579)1.67620335
155Recurrent skin infections (HP:0001581)1.67159696
156Ragged-red muscle fibers (HP:0003200)1.66756265
157Segmental peripheral demyelination/remyelination (HP:0003481)1.66239067
158Lower limb amyotrophy (HP:0007210)1.64816739
159Long palpebral fissure (HP:0000637)1.63783000
160Peripheral demyelination (HP:0011096)1.62672068
161Deformed sella turcica (HP:0002681)1.61780648
162Osteomyelitis (HP:0002754)1.60881908

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.46833373
2PRPF4B3.21577433
3TAOK33.13882710
4TRIB33.08626880
5IRAK33.04744458
6PRKD32.95944972
7SCYL22.87685943
8ICK2.58021883
9MAP3K92.53173980
10NME22.50908461
11PKN22.41277778
12RIPK12.10928583
13CDC42BPA2.04552329
14NTRK32.04373280
15CAMKK11.99498028
16MINK11.94241908
17ERN11.88412735
18KSR21.85965675
19NEK11.85798274
20CDK121.84386873
21DAPK21.83645065
22TESK21.72866760
23LMTK21.71265787
24MAP3K101.70405823
25RET1.66055264
26EEF2K1.62969831
27TESK11.61998349
28FGFR41.53158665
29MAP2K41.48765858
30PAK61.43753125
31PRKCH1.36760302
32MAP3K41.35915607
33STK381.33419185
34TAOK11.32167078
35ARAF1.31981711
36MAP3K141.31928378
37JAK11.31119298
38MAP3K21.29166415
39MAP4K11.28245857
40NTRK11.27600298
41ALK1.25122590
42JAK21.21936485
43DAPK11.21475287
44KDR1.20877659
45TYK21.16609074
46MAP3K31.14807367
47TAOK21.13527832
48SGK31.13217343
49EPHA21.13160067
50MAP3K11.10193232
51PDK11.07293056
52RPS6KA21.07127605
53IRAK41.06986790
54MARK21.05358416
55MAP3K121.03926306
56MARK11.01408280
57TTN1.01299070
58FES1.00532820
59PIM20.99263659
60SIK20.99245838
61PRKD20.96718250
62KSR10.95860903
63MAP2K60.95184344
64TGFBR20.93277382
65PTK60.91735939
66ZAP700.91025832
67IRAK20.90549217
68NTRK20.89109026
69CAMKK20.88956080
70SIK30.88490938
71CDK50.87926411
72HIPK20.86024252
73PDGFRA0.84384131
74MAP3K110.83368933
75MTOR0.83328206
76BMX0.82890016
77MAP3K80.82640836
78PTK20.82148736
79BLK0.78228702
80JAK30.77069906
81SGK20.75393095
82SYK0.74044374
83PDPK10.73772489
84TNK20.72868103
85CDK40.72849676
86CSK0.70446200
87MAPK110.66491082
88CDK60.66322557
89RPS6KL10.66147752
90RPS6KC10.66147752
91CAMK1D0.65981259
92LRRK20.65788677
93UHMK10.63872555
94BCKDK0.63866105
95PINK10.63288807
96PTK2B0.62594420
97CAMK1G0.62319383
98MST1R0.61693376
99DDR20.61573797
100BTK0.61343344
101RIPK40.60987928
102PHKG20.60261692
103PHKG10.60261692
104BRAF0.58807866
105PASK0.58573135
106EPHB10.57659216
107MAP2K30.57036448
108FGFR30.56284932
109CAMK40.56075630
110FGR0.55963400
111MAP2K20.54764126
112MAP3K50.53965450
113CSF1R0.53646183
114SIK10.53033964
115NEK90.52981853
116MAP2K10.52636024
117SGK2230.52406515
118SGK4940.52406515
119INSRR0.52183872
120CDK90.52130427
121TYRO30.51742234
122MAP3K60.51605920
123EPHA40.51472133
124MAPK120.50603927
125BRSK10.50530378
126TBK10.50052452
127PRKG20.49929793
128PRKAA10.49398201
129PRKCG0.47342055
130STK110.47325952
131ERBB20.47100496
132MATK0.47081656
133MAP3K130.47073241
134FER0.45597979
135GRK50.45517948
136GRK60.45187532
137PRKACG0.44751535
138DYRK1B0.44517827
139IKBKE0.43797522
140FLT30.43545027
141HCK0.42736727
142RPS6KA60.42622158
143CDK70.41218545
144MOS0.40092823
145IKBKB0.40051228
146MAP2K70.39885168
147PAK40.39877721
148RPS6KB20.36289619
149ABL20.35814102
150STK100.33989402
151LYN0.32976814

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.09795372
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.62824325
3Nitrogen metabolism_Homo sapiens_hsa009102.48027629
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26866111
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26322904
6Insulin secretion_Homo sapiens_hsa049111.99418459
7Olfactory transduction_Homo sapiens_hsa047401.99136196
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.93397012
9Acute myeloid leukemia_Homo sapiens_hsa052211.84653334
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84536064
11Leishmaniasis_Homo sapiens_hsa051401.83240057
12Staphylococcus aureus infection_Homo sapiens_hsa051501.82539569
13Type II diabetes mellitus_Homo sapiens_hsa049301.81571968
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80041380
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.79465957
16* Lysosome_Homo sapiens_hsa041421.75891134
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.69029165
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.60784078
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60283952
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58982039
21Bladder cancer_Homo sapiens_hsa052191.58601639
22GABAergic synapse_Homo sapiens_hsa047271.51420264
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46163721
24Pentose phosphate pathway_Homo sapiens_hsa000301.41537382
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39258705
26Circadian entrainment_Homo sapiens_hsa047131.39240325
27Long-term potentiation_Homo sapiens_hsa047201.38819393
28Notch signaling pathway_Homo sapiens_hsa043301.35209461
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.33162701
30Toxoplasmosis_Homo sapiens_hsa051451.30691800
31Phagosome_Homo sapiens_hsa041451.26909859
32Other glycan degradation_Homo sapiens_hsa005111.24478436
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23767273
34Pancreatic cancer_Homo sapiens_hsa052121.22107838
35Dopaminergic synapse_Homo sapiens_hsa047281.20990545
36Morphine addiction_Homo sapiens_hsa050321.18443016
37Galactose metabolism_Homo sapiens_hsa000521.18017341
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17415394
39Cholinergic synapse_Homo sapiens_hsa047251.16185723
40Influenza A_Homo sapiens_hsa051641.14922937
41mTOR signaling pathway_Homo sapiens_hsa041501.14886829
42Salmonella infection_Homo sapiens_hsa051321.14136473
43Arginine biosynthesis_Homo sapiens_hsa002201.13112507
44Gastric acid secretion_Homo sapiens_hsa049711.10212609
45Insulin signaling pathway_Homo sapiens_hsa049101.07914325
46Apoptosis_Homo sapiens_hsa042101.06916384
47Pertussis_Homo sapiens_hsa051331.05970173
48Amphetamine addiction_Homo sapiens_hsa050311.05125124
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.04956310
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.04074565
51Phototransduction_Homo sapiens_hsa047441.03394358
52Hepatitis B_Homo sapiens_hsa051611.03253827
53Asthma_Homo sapiens_hsa053101.03001856
54Salivary secretion_Homo sapiens_hsa049701.02355378
55Antigen processing and presentation_Homo sapiens_hsa046121.01467861
56VEGF signaling pathway_Homo sapiens_hsa043701.00600270
57Bile secretion_Homo sapiens_hsa049760.99827913
58Hepatitis C_Homo sapiens_hsa051600.99805216
59Allograft rejection_Homo sapiens_hsa053300.99050325
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97441807
61Renal cell carcinoma_Homo sapiens_hsa052110.97387542
62Viral myocarditis_Homo sapiens_hsa054160.96541530
63Shigellosis_Homo sapiens_hsa051310.95603445
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.94858854
65Non-small cell lung cancer_Homo sapiens_hsa052230.94827194
66TNF signaling pathway_Homo sapiens_hsa046680.94624666
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.94320407
68Collecting duct acid secretion_Homo sapiens_hsa049660.93355200
69Fructose and mannose metabolism_Homo sapiens_hsa000510.93187963
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92721733
71Glioma_Homo sapiens_hsa052140.91410508
72Endocytosis_Homo sapiens_hsa041440.91176097
73Oxytocin signaling pathway_Homo sapiens_hsa049210.90749262
74GnRH signaling pathway_Homo sapiens_hsa049120.89519570
75Insulin resistance_Homo sapiens_hsa049310.89440466
76Rheumatoid arthritis_Homo sapiens_hsa053230.89207121
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88944496
78Cocaine addiction_Homo sapiens_hsa050300.88675371
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87818456
80Glucagon signaling pathway_Homo sapiens_hsa049220.87324879
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87154594
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.86664832
83Renin secretion_Homo sapiens_hsa049240.86646202
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86016277
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85782181
86Biosynthesis of amino acids_Homo sapiens_hsa012300.85415870
87ABC transporters_Homo sapiens_hsa020100.84638155
88Autoimmune thyroid disease_Homo sapiens_hsa053200.83586909
89Estrogen signaling pathway_Homo sapiens_hsa049150.83521231
90Glutamatergic synapse_Homo sapiens_hsa047240.81888312
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81170624
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80680953
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.80601800
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79800783
95Amoebiasis_Homo sapiens_hsa051460.79649781
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77759297
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77243928
98Selenocompound metabolism_Homo sapiens_hsa004500.76887306
99Thyroid cancer_Homo sapiens_hsa052160.76720695
100Thyroid hormone synthesis_Homo sapiens_hsa049180.73663099
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73535050
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73368194
103Tryptophan metabolism_Homo sapiens_hsa003800.73074198
104Herpes simplex infection_Homo sapiens_hsa051680.73005128
105Nicotine addiction_Homo sapiens_hsa050330.72651796
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71832092
107Chronic myeloid leukemia_Homo sapiens_hsa052200.70690862
108Viral carcinogenesis_Homo sapiens_hsa052030.70646374
109HIF-1 signaling pathway_Homo sapiens_hsa040660.70464363
110Graft-versus-host disease_Homo sapiens_hsa053320.70143583
111Pancreatic secretion_Homo sapiens_hsa049720.70060441
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.69631073
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69600123
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68991962
115Platelet activation_Homo sapiens_hsa046110.68117580
116Endometrial cancer_Homo sapiens_hsa052130.67721858
117Vibrio cholerae infection_Homo sapiens_hsa051100.67708735
118Carbon metabolism_Homo sapiens_hsa012000.67324579
119HTLV-I infection_Homo sapiens_hsa051660.66532893
120Legionellosis_Homo sapiens_hsa051340.64945175
121Prolactin signaling pathway_Homo sapiens_hsa049170.64733090
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64243726
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64113487
124Malaria_Homo sapiens_hsa051440.63153127
125Tuberculosis_Homo sapiens_hsa051520.62404317
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61506013
127Sphingolipid metabolism_Homo sapiens_hsa006000.61087922
128Epstein-Barr virus infection_Homo sapiens_hsa051690.60815015
129Hematopoietic cell lineage_Homo sapiens_hsa046400.59799542
130Prostate cancer_Homo sapiens_hsa052150.59762059
131Chemokine signaling pathway_Homo sapiens_hsa040620.58766224
132Gap junction_Homo sapiens_hsa045400.58364277
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.58204271
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58119855
135Osteoclast differentiation_Homo sapiens_hsa043800.56365804
136T cell receptor signaling pathway_Homo sapiens_hsa046600.56292094
137Measles_Homo sapiens_hsa051620.55724302
138Type I diabetes mellitus_Homo sapiens_hsa049400.55285756
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53848288
140B cell receptor signaling pathway_Homo sapiens_hsa046620.53469439
141Prion diseases_Homo sapiens_hsa050200.52950372
142AMPK signaling pathway_Homo sapiens_hsa041520.52741108
143cAMP signaling pathway_Homo sapiens_hsa040240.52334114
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51931286
145Proteoglycans in cancer_Homo sapiens_hsa052050.51629600
146Fat digestion and absorption_Homo sapiens_hsa049750.50666644
147Choline metabolism in cancer_Homo sapiens_hsa052310.50629911
148Taste transduction_Homo sapiens_hsa047420.48689487
149Dorso-ventral axis formation_Homo sapiens_hsa043200.47221423
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.46575294
151Circadian rhythm_Homo sapiens_hsa047100.43881590
152Colorectal cancer_Homo sapiens_hsa052100.43457904
153Inositol phosphate metabolism_Homo sapiens_hsa005620.43232484
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43031867
155ErbB signaling pathway_Homo sapiens_hsa040120.42786735
156Starch and sucrose metabolism_Homo sapiens_hsa005000.42567171

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