ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.56759185
2	piRNA metabolic process (GO:0034587)	4.56735614
3	centriole replication (GO:0007099)	4.52890350
4	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.32781647
5	outer ear morphogenesis (GO:0042473)	4.29884259
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.14092414
7	multicellular organism reproduction (GO:0032504)	4.13759723
8	male meiosis (GO:0007140)	4.10582068
9	fucose catabolic process (GO:0019317)	3.80507753
10	L-fucose metabolic process (GO:0042354)	3.80507753
11	L-fucose catabolic process (GO:0042355)	3.80507753
12	cell wall macromolecule catabolic process (GO:0016998)	3.80439008
13	reflex (GO:0060004)	3.78226447
14	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.73410792
15	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.73410792
16	nonmotile primary cilium assembly (GO:0035058)	3.66566424
17	polyamine biosynthetic process (GO:0006596)	3.65917803
18	nephron epithelium morphogenesis (GO:0072088)	3.65525773
19	nephron tubule morphogenesis (GO:0072078)	3.65525773
20	artery development (GO:0060840)	3.61003079
21	monoubiquitinated protein deubiquitination (GO:0035520)	3.60355567
22	cellular biogenic amine biosynthetic process (GO:0042401)	3.57949635
23	epithelial cilium movement (GO:0003351)	3.52685827
24	regulation of cilium movement (GO:0003352)	3.46784334
25	cellular biogenic amine catabolic process (GO:0042402)	3.45340144
26	amine catabolic process (GO:0009310)	3.45340144
27	arachidonic acid secretion (GO:0050482)	3.41846382
28	icosanoid secretion (GO:0032309)	3.41846382
29	behavioral response to nicotine (GO:0035095)	3.40167001
30	protein polyglutamylation (GO:0018095)	3.39902657
31	DNA methylation involved in gamete generation (GO:0043046)	3.37721638
32	amine biosynthetic process (GO:0009309)	3.36969184
33	cilium morphogenesis (GO:0060271)	3.36824107
34	regulation of neurotransmitter uptake (GO:0051580)	3.35689614
35	cell morphogenesis involved in neuron differentiation (GO:0048667)	3.32645883
36	acrosome reaction (GO:0007340)	3.32240159
37	ubiquinone biosynthetic process (GO:0006744)	3.32067627
38	ubiquinone metabolic process (GO:0006743)	3.31069227
39	striatum development (GO:0021756)	3.26149305
40	negative regulation of telomere maintenance (GO:0032205)	3.22303702
41	cell wall macromolecule metabolic process (GO:0044036)	3.16085679
42	synapsis (GO:0007129)	3.14101071
43	inositol phosphate-mediated signaling (GO:0048016)	3.08498071
44	G-protein coupled receptor internalization (GO:0002031)	3.08099159
45	detection of light stimulus involved in sensory perception (GO:0050962)	3.06568018
46	detection of light stimulus involved in visual perception (GO:0050908)	3.06568018
47	negative regulation of glial cell differentiation (GO:0045686)	3.06566373
48	head development (GO:0060322)	2.94831526
49	neuron fate determination (GO:0048664)	2.94447555
50	sperm-egg recognition (GO:0035036)	2.93139048
51	indolalkylamine metabolic process (GO:0006586)	2.89459576
52	cilium organization (GO:0044782)	2.88365800
53	cilium assembly (GO:0042384)	2.87926366
54	auditory receptor cell stereocilium organization (GO:0060088)	2.85644116
55	behavioral response to cocaine (GO:0048148)	2.83728718
56	centriole assembly (GO:0098534)	2.80481702
57	cilium movement (GO:0003341)	2.80017674
58	spermatid development (GO:0007286)	2.78172242
59	quinone biosynthetic process (GO:1901663)	2.72882371
60	regulation of acrosome reaction (GO:0060046)	2.71529474
61	platelet dense granule organization (GO:0060155)	2.70841828
62	musculoskeletal movement (GO:0050881)	2.70279383
63	multicellular organismal movement (GO:0050879)	2.70279383
64	glomerular basement membrane development (GO:0032836)	2.70107319
65	protein import into peroxisome matrix (GO:0016558)	2.69191375
66	photoreceptor cell maintenance (GO:0045494)	2.66128694
67	recombinational repair (GO:0000725)	2.65584453
68	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.63940778
69	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.63940778
70	renal tubule morphogenesis (GO:0061333)	2.63785063
71	neuronal stem cell maintenance (GO:0097150)	2.63775491
72	cochlea development (GO:0090102)	2.61930472
73	meiotic chromosome segregation (GO:0045132)	2.60188456
74	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.58770963
75	prepulse inhibition (GO:0060134)	2.58334033
76	primary amino compound metabolic process (GO:1901160)	2.58021137
77	icosanoid transport (GO:0071715)	2.57957785
78	fatty acid derivative transport (GO:1901571)	2.57957785
79	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.57002086
80	neuronal action potential (GO:0019228)	2.56179147
81	double-strand break repair via homologous recombination (GO:0000724)	2.55333365
82	phasic smooth muscle contraction (GO:0014821)	2.53678945
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.53154047
84	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.53154047
85	acrosome assembly (GO:0001675)	2.51657472
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.50273551
87	anterior/posterior axis specification, embryo (GO:0008595)	2.49923721
88	glomerular filtration (GO:0003094)	2.49614360
89	mitotic cell cycle arrest (GO:0071850)	2.48540757
90	regulation of telomere maintenance (GO:0032204)	2.45060013
91	cell-cell recognition (GO:0009988)	2.43425065
92	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.43226937
93	sperm motility (GO:0030317)	2.42801979
94	peristalsis (GO:0030432)	2.42541210
95	polyamine metabolic process (GO:0006595)	2.41720133
96	cytidine metabolic process (GO:0046087)	2.41705570
97	cytidine catabolic process (GO:0006216)	2.41705570
98	cytidine deamination (GO:0009972)	2.41705570
99	smooth muscle contraction (GO:0006939)	2.41379516
100	histone mRNA catabolic process (GO:0071044)	2.41285887

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.36163764
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.09352135
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.01131772
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.49362470
5	VDR_22108803_ChIP-Seq_LS180_Human	3.28393199
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.13579679
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.91088996
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.85152553
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44982234
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.41743007
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37472222
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.25658545
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.20262562
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.00841099
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.99992773
16	FUS_26573619_Chip-Seq_HEK293_Human	1.99151551
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94510808
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94181409
19	EWS_26573619_Chip-Seq_HEK293_Human	1.93139725
20	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.92291659
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.91373364
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.90989360
23	P300_19829295_ChIP-Seq_ESCs_Human	1.89137026
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.86241487
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.81011872
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77487297
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.63804485
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63587623
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62711914
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.62479198
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.62479198
32	STAT3_23295773_ChIP-Seq_U87_Human	1.59882803
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54280156
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54152657
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53255509
36	AR_25329375_ChIP-Seq_VCAP_Human	1.52450632
37	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.49713948
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.47364574
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46599009
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46599009
41	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45530165
42	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45530165
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.45485445
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43616087
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42684022
46	TCF4_23295773_ChIP-Seq_U87_Human	1.40942127
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.40547837
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40102342
49	GATA1_22025678_ChIP-Seq_K562_Human	1.35335344
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35149884
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33666688
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33300016
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33181131
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32833766
55	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.31206220
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.29294697
57	ELK1_19687146_ChIP-ChIP_HELA_Human	1.28983264
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27930132
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27829272
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27501537
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.27379969
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27008077
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26880937
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.23873563
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23058291
66	CDX2_22108803_ChIP-Seq_LS180_Human	1.22554038
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21668679
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20863357
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20249141
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18957739
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.18197871
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17062034
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16261416
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15984348
75	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.14277231
76	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.14048732
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.12405115
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11777243
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.11678972
80	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.10977190
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10948247
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09522083
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07749084
84	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.07519676
85	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06074814
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03262215
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02458772
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01397648
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.01096369
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00067616
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00067616
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99516733
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98917434
94	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98307754
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97802440
96	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.94742315
97	NCOR_22424771_ChIP-Seq_293T_Human	0.94155472
98	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.93953556
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93877975
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93460937

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001984_abnormal_olfaction	3.49528289
2	MP0008877_abnormal_DNA_methylation	3.48606985
3	MP0002653_abnormal_ependyma_morphology	3.25247306
4	MP0002102_abnormal_ear_morphology	2.81818238
5	MP0005360_urolithiasis	2.67963301
6	MP0005451_abnormal_body_composition	2.61111146
7	MP0003136_yellow_coat_color	2.55301230
8	MP0001485_abnormal_pinna_reflex	2.55034581
9	MP0005410_abnormal_fertilization	2.44279951
10	MP0004885_abnormal_endolymph	2.42744076
11	MP0003195_calcinosis	2.38527110
12	MP0005551_abnormal_eye_electrophysiolog	2.35695299
13	MP0010030_abnormal_orbit_morphology	2.34866688
14	MP0000569_abnormal_digit_pigmentation	2.34422710
15	MP0008789_abnormal_olfactory_epithelium	2.34102800
16	MP0003880_abnormal_central_pattern	2.29863977
17	MP0009046_muscle_twitch	2.17985238
18	MP0008872_abnormal_physiological_respon	2.13023898
19	MP0000631_abnormal_neuroendocrine_gland	2.00034661
20	MP0003718_maternal_effect	1.99093890
21	MP0000372_irregular_coat_pigmentation	1.96541966
22	MP0010386_abnormal_urinary_bladder	1.91614562
23	MP0005646_abnormal_pituitary_gland	1.78593015
24	MP0003950_abnormal_plasma_membrane	1.77392178
25	MP0004145_abnormal_muscle_electrophysio	1.74370297
26	MP0000538_abnormal_urinary_bladder	1.71632356
27	MP0001486_abnormal_startle_reflex	1.67516879
28	MP0002928_abnormal_bile_duct	1.64114292
29	MP0002735_abnormal_chemical_nociception	1.62524195
30	MP0002638_abnormal_pupillary_reflex	1.61935484
31	MP0009697_abnormal_copulation	1.61435827
32	MP0000427_abnormal_hair_cycle	1.55382573
33	MP0005394_taste/olfaction_phenotype	1.51631432
34	MP0005499_abnormal_olfactory_system	1.51631432
35	MP0002876_abnormal_thyroid_physiology	1.51179623
36	MP0001929_abnormal_gametogenesis	1.44334979
37	MP0006072_abnormal_retinal_apoptosis	1.44298007
38	MP0001502_abnormal_circadian_rhythm	1.41591354
39	MP0002736_abnormal_nociception_after	1.40162603
40	MP0000566_synostosis	1.40081292
41	MP0000383_abnormal_hair_follicle	1.37201383
42	MP0005395_other_phenotype	1.36965688
43	MP0002160_abnormal_reproductive_system	1.35290237
44	MP0008875_abnormal_xenobiotic_pharmacok	1.35071646
45	MP0005253_abnormal_eye_physiology	1.30380248
46	MP0006292_abnormal_olfactory_placode	1.26839740
47	MP0000049_abnormal_middle_ear	1.26415449
48	MP0005310_abnormal_salivary_gland	1.24912045
49	MP0005084_abnormal_gallbladder_morpholo	1.24845438
50	MP0009745_abnormal_behavioral_response	1.24333436
51	MP0004742_abnormal_vestibular_system	1.22943316
52	MP0003938_abnormal_ear_development	1.21898773
53	MP0002751_abnormal_autonomic_nervous	1.21894579
54	MP0008004_abnormal_stomach_pH	1.21242052
55	MP0004142_abnormal_muscle_tone	1.20898335
56	MP0000371_diluted_coat_color	1.19662535
57	MP0002272_abnormal_nervous_system	1.17556047
58	MP0003698_abnormal_male_reproductive	1.14485290
59	MP0002210_abnormal_sex_determination	1.14419319
60	MP0000013_abnormal_adipose_tissue	1.13330204
61	MP0002233_abnormal_nose_morphology	1.13298359
62	MP0001440_abnormal_grooming_behavior	1.12037359
63	MP0001986_abnormal_taste_sensitivity	1.11238494
64	MP0001501_abnormal_sleep_pattern	1.10282358
65	MP0001968_abnormal_touch/_nociception	1.10018424
66	MP0002168_other_aberrant_phenotype	1.09027627
67	MP0003315_abnormal_perineum_morphology	1.07240409
68	MP0002277_abnormal_respiratory_mucosa	1.05400081
69	MP0010094_abnormal_chromosome_stability	1.04783916
70	MP0001324_abnormal_eye_pigmentation	1.01690328
71	MP0000026_abnormal_inner_ear	0.99089796
72	MP0001970_abnormal_pain_threshold	0.98422982
73	MP0000653_abnormal_sex_gland	0.97636318
74	MP0004215_abnormal_myocardial_fiber	0.94139780
75	MP0005195_abnormal_posterior_eye	0.93553063
76	MP0002067_abnormal_sensory_capabilities	0.91992680
77	MP0000778_abnormal_nervous_system	0.90165676
78	MP0002282_abnormal_trachea_morphology	0.90088049
79	MP0002734_abnormal_mechanical_nocicepti	0.89612066
80	MP0002938_white_spotting	0.89341695
81	MP0005171_absent_coat_pigmentation	0.86920474
82	MP0001764_abnormal_homeostasis	0.86638191
83	MP0010307_abnormal_tumor_latency	0.86121106
84	MP0003755_abnormal_palate_morphology	0.85840173
85	MP0005389_reproductive_system_phenotype	0.85355710
86	MP0003186_abnormal_redox_activity	0.83511269
87	MP0001145_abnormal_male_reproductive	0.83347075
88	MP0008058_abnormal_DNA_repair	0.79316200
89	MP0000015_abnormal_ear_pigmentation	0.79241918
90	MP0004147_increased_porphyrin_level	0.78521068
91	MP0002572_abnormal_emotion/affect_behav	0.78511704
92	MP0010678_abnormal_skin_adnexa	0.77492829
93	MP0002234_abnormal_pharynx_morphology	0.75313652
94	MP0002837_dystrophic_cardiac_calcinosis	0.74982998
95	MP0002108_abnormal_muscle_morphology	0.74447031
96	MP0005174_abnormal_tail_pigmentation	0.73668589
97	MP0002069_abnormal_eating/drinking_beha	0.69411044
98	MP0001756_abnormal_urination	0.68808181
99	MP0000613_abnormal_salivary_gland	0.68366699
100	MP0008995_early_reproductive_senescence	0.68147304

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	5.28916172
2	Pancreatic fibrosis (HP:0100732)	4.77520968
3	True hermaphroditism (HP:0010459)	4.65531385
4	Abnormality of midbrain morphology (HP:0002418)	4.31419925
5	Molar tooth sign on MRI (HP:0002419)	4.31419925
6	Medial flaring of the eyebrow (HP:0010747)	3.90766226
7	Gait imbalance (HP:0002141)	3.80694032
8	Congenital primary aphakia (HP:0007707)	3.78965183
9	Abnormality of the renal cortex (HP:0011035)	3.78581151
10	Cystic liver disease (HP:0006706)	3.68675828
11	Broad distal phalanx of finger (HP:0009836)	3.29414772
12	Nephrogenic diabetes insipidus (HP:0009806)	3.29023186
13	Nephronophthisis (HP:0000090)	3.24670908
14	Optic nerve hypoplasia (HP:0000609)	3.21470390
15	Abnormality of the renal medulla (HP:0100957)	3.06191489
16	Large for gestational age (HP:0001520)	3.06179901
17	Tubular atrophy (HP:0000092)	3.05918777
18	Type II lissencephaly (HP:0007260)	2.87569017
19	Sclerocornea (HP:0000647)	2.81487023
20	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.79052947
21	Poor coordination (HP:0002370)	2.77795374
22	Hypoplasia of the uterus (HP:0000013)	2.76682045
23	Male pseudohermaphroditism (HP:0000037)	2.76451843
24	Furrowed tongue (HP:0000221)	2.74679848
25	Genital tract atresia (HP:0001827)	2.73528636
26	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.72816966
27	Vaginal atresia (HP:0000148)	2.71391849
28	Renal cortical cysts (HP:0000803)	2.68889031
29	Septo-optic dysplasia (HP:0100842)	2.66821264
30	Intestinal atresia (HP:0011100)	2.65187193
31	Gaze-evoked nystagmus (HP:0000640)	2.64127455
32	Azoospermia (HP:0000027)	2.56161137
33	11 pairs of ribs (HP:0000878)	2.53970501
34	Abnormality of the fovea (HP:0000493)	2.49687586
35	Chronic hepatic failure (HP:0100626)	2.48660496
36	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.47409422
37	Inability to walk (HP:0002540)	2.46320444
38	Cerebellar dysplasia (HP:0007033)	2.43389398
39	Abnormal drinking behavior (HP:0030082)	2.41913056
40	Polydipsia (HP:0001959)	2.41913056
41	Hypoplastic labia majora (HP:0000059)	2.41071400
42	Occipital encephalocele (HP:0002085)	2.40405234
43	Polyuria (HP:0000103)	2.36924718
44	Congenital stationary night blindness (HP:0007642)	2.35413416
45	Irregular vertebral endplates (HP:0003301)	2.32315038
46	Bile duct proliferation (HP:0001408)	2.31016377
47	Abnormal biliary tract physiology (HP:0012439)	2.31016377
48	Hypoplasia of the fovea (HP:0007750)	2.26776341
49	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.26776341
50	Congenital hepatic fibrosis (HP:0002612)	2.26382930
51	Progressive cerebellar ataxia (HP:0002073)	2.24906312
52	Aplasia/Hypoplasia of the lens (HP:0008063)	2.22816971
53	Abnormality of the labia majora (HP:0012881)	2.22790969
54	Albinism (HP:0001022)	2.19579023
55	Progressive inability to walk (HP:0002505)	2.19114718
56	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.17798064
57	Aplasia/hypoplasia of the uterus (HP:0008684)	2.13522301
58	Anencephaly (HP:0002323)	2.12557655
59	Hypoplastic ischia (HP:0003175)	2.12037563
60	Genetic anticipation (HP:0003743)	2.10227524
61	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.08844135
62	Increased corneal curvature (HP:0100692)	2.06551217
63	Keratoconus (HP:0000563)	2.06551217
64	Broad foot (HP:0001769)	2.04325510
65	Left ventricular hypertrophy (HP:0001712)	2.04256702
66	Postaxial hand polydactyly (HP:0001162)	2.03998777
67	Highly arched eyebrow (HP:0002553)	2.03516992
68	Abnormal spermatogenesis (HP:0008669)	2.03093130
69	Abnormal pancreas size (HP:0012094)	2.01248947
70	Chorioretinal coloboma (HP:0000567)	2.00946640
71	Abnormality of renal excretion (HP:0011036)	1.98944782
72	Delayed gross motor development (HP:0002194)	1.98723123
73	Aganglionic megacolon (HP:0002251)	1.98483260
74	Tubulointerstitial fibrosis (HP:0005576)	1.97918940
75	Gastrointestinal atresia (HP:0002589)	1.92978779
76	Abnormal urine output (HP:0012590)	1.92477636
77	Retinal dysplasia (HP:0007973)	1.92017995
78	Abnormality of the vertebral endplates (HP:0005106)	1.91945934
79	Anophthalmia (HP:0000528)	1.91705378
80	Postaxial foot polydactyly (HP:0001830)	1.90715598
81	Abnormality of macular pigmentation (HP:0008002)	1.89221486
82	Preaxial hand polydactyly (HP:0001177)	1.87423553
83	Abnormality of renal resorption (HP:0011038)	1.87040628
84	Supernumerary spleens (HP:0009799)	1.85860673
85	Prominent supraorbital ridges (HP:0000336)	1.84752467
86	Sloping forehead (HP:0000340)	1.83589362
87	Mesangial abnormality (HP:0001966)	1.81796770
88	Multicystic kidney dysplasia (HP:0000003)	1.81396304
89	Generalized hypopigmentation of hair (HP:0011358)	1.80131712
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78876851
91	Absent/shortened dynein arms (HP:0200106)	1.78876851
92	Lip pit (HP:0100267)	1.78716170
93	Tubulointerstitial abnormality (HP:0001969)	1.77693082
94	Bicornuate uterus (HP:0000813)	1.76949738
95	Hyperventilation (HP:0002883)	1.73721326
96	Facial hemangioma (HP:0000329)	1.73070671
97	Abnormality of the labia minora (HP:0012880)	1.71852252
98	Hyperaldosteronism (HP:0000859)	1.69226067
99	Abolished electroretinogram (ERG) (HP:0000550)	1.68228927
100	Dandy-Walker malformation (HP:0001305)	1.67696249

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.07359236
2	ZAK	3.85206338
3	CASK	3.51474526
4	TLK1	3.26396557
5	PINK1	3.17577745
6	ACVR1B	3.08565725
7	ADRBK2	2.74351412
8	MST4	2.55491614
9	BMPR1B	2.52736136
10	MAPK13	2.31117094
11	GRK1	2.24771038
12	BRSK2	2.19059748
13	WEE1	2.16586959
14	NTRK3	2.12485854
15	MAP3K9	1.99101688
16	EIF2AK3	1.90718009
17	KSR1	1.81289325
18	NUAK1	1.80248484
19	STK39	1.70852246
20	TNK2	1.67661581
21	PAK3	1.61360159
22	BCKDK	1.50177589
23	OXSR1	1.47450462
24	RAF1	1.44839245
25	PKN1	1.31875879
26	WNK3	1.31685474
27	TRIM28	1.24839860
28	MUSK	1.24373605
29	KSR2	1.16608809
30	MARK3	1.16255445
31	MAP3K2	1.07124033
32	PIK3CA	1.00894399
33	WNK4	0.97098019
34	TGFBR1	0.96767972
35	STK38L	0.91912421
36	CSNK1G3	0.90554432
37	VRK1	0.90121756
38	ERBB3	0.90001481
39	MAP2K7	0.89633169
40	MAP4K2	0.89295936
41	MAP3K4	0.87910047
42	TRPM7	0.87499095
43	TNIK	0.85579953
44	CSNK1G1	0.85055663
45	PLK4	0.81382478
46	CSNK1G2	0.79451988
47	WNK1	0.79388961
48	PRKCE	0.76162628
49	PRKCQ	0.74588872
50	PAK6	0.73108689
51	TEC	0.72387979
52	MKNK2	0.71861971
53	EPHA4	0.69618336
54	LMTK2	0.69591081
55	RPS6KA5	0.68765178
56	ROCK1	0.68303442
57	PIM1	0.68007015
58	PLK3	0.65782317
59	NEK2	0.65654979
60	TIE1	0.65482724
61	CSNK1A1L	0.63990316
62	PLK2	0.63280805
63	STK24	0.63005977
64	TAOK3	0.61411791
65	DAPK2	0.61223784
66	DYRK2	0.60054679
67	STK3	0.57317670
68	PLK1	0.57088374
69	FGFR2	0.56940495
70	MELK	0.56480674
71	INSRR	0.55586694
72	PIK3CG	0.52812779
73	PRKAA1	0.51751789
74	IKBKB	0.50445543
75	MAPKAPK3	0.50281029
76	PRKCI	0.48024038
77	MAP3K13	0.47499728
78	PTK2B	0.45399352
79	ADRBK1	0.44152833
80	CHEK2	0.43563458
81	EPHB2	0.42731305
82	BCR	0.42203988
83	STK38	0.42182641
84	MARK1	0.41523698
85	CDK8	0.40705654
86	CDK3	0.34847643
87	CSNK1D	0.34721461
88	SGK2	0.33746502
89	ATM	0.32393283
90	MYLK	0.31845668
91	GRK7	0.31529264
92	BRSK1	0.30848881
93	FER	0.29948607
94	CCNB1	0.29169737
95	MINK1	0.27913995
96	IKBKE	0.27825563
97	CSNK1A1	0.27420100
98	CAMK1	0.27159033
99	CAMK2A	0.27007475
100	PRKAA2	0.26943428

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	4.49701585
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.04648488
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.80965126
4	Phototransduction_Homo sapiens_hsa04744	2.80215094
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.43888800
6	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.43583550
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.29652067
8	Butanoate metabolism_Homo sapiens_hsa00650	2.15912470
9	Propanoate metabolism_Homo sapiens_hsa00640	2.15678493
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15129823
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10468886
12	Regulation of autophagy_Homo sapiens_hsa04140	2.06266302
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.87136998
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.87043809
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86500233
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.76684326
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71666788
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67800787
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66900411
20	Taste transduction_Homo sapiens_hsa04742	1.63980468
21	Caffeine metabolism_Homo sapiens_hsa00232	1.61167766
22	Circadian rhythm_Homo sapiens_hsa04710	1.51939227
23	Protein export_Homo sapiens_hsa03060	1.49896458
24	Homologous recombination_Homo sapiens_hsa03440	1.46093765
25	Basal transcription factors_Homo sapiens_hsa03022	1.41009362
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.40600493
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.37701853
28	Mineral absorption_Homo sapiens_hsa04978	1.35093934
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.33306758
30	Peroxisome_Homo sapiens_hsa04146	1.32799084
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32776360
32	RNA degradation_Homo sapiens_hsa03018	1.30468037
33	Olfactory transduction_Homo sapiens_hsa04740	1.26700162
34	Nicotine addiction_Homo sapiens_hsa05033	1.26402431
35	ABC transporters_Homo sapiens_hsa02010	1.19604954
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17694775
37	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.17612249
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16413501
39	RNA polymerase_Homo sapiens_hsa03020	1.10565578
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08620165
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.08059974
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07793904
43	Base excision repair_Homo sapiens_hsa03410	1.07287704
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.05346435
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.03758073
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98447645
47	Retinol metabolism_Homo sapiens_hsa00830	0.94030825
48	Nucleotide excision repair_Homo sapiens_hsa03420	0.90123947
49	Oocyte meiosis_Homo sapiens_hsa04114	0.90106369
50	Insulin secretion_Homo sapiens_hsa04911	0.86849112
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.86674382
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.83749322
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.83362726
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81841603
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79230031
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77060698
57	Sulfur metabolism_Homo sapiens_hsa00920	0.76727999
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.75872286
59	Mismatch repair_Homo sapiens_hsa03430	0.74311395
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73979237
61	RNA transport_Homo sapiens_hsa03013	0.71549627
62	Cocaine addiction_Homo sapiens_hsa05030	0.67742740
63	Lysine degradation_Homo sapiens_hsa00310	0.65722280
64	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.57561790
65	Serotonergic synapse_Homo sapiens_hsa04726	0.57040267
66	p53 signaling pathway_Homo sapiens_hsa04115	0.55227512
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55032092
68	Salivary secretion_Homo sapiens_hsa04970	0.54282642
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53777661
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53359250
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.53254539
72	Gastric acid secretion_Homo sapiens_hsa04971	0.52842058
73	Morphine addiction_Homo sapiens_hsa05032	0.50234013
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50230194
75	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49257701
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.48255555
77	Glutathione metabolism_Homo sapiens_hsa00480	0.47855406
78	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.47274537
79	Purine metabolism_Homo sapiens_hsa00230	0.46685133
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.46565604
81	Fatty acid degradation_Homo sapiens_hsa00071	0.45181683
82	Metabolic pathways_Homo sapiens_hsa01100	0.41971300
83	Circadian entrainment_Homo sapiens_hsa04713	0.41967546
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.40775358
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39742332
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38664830
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.36802202
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36560349
89	GABAergic synapse_Homo sapiens_hsa04727	0.35520846
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.35352988
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.34613355
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34131865
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.33351690
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33140948
95	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31921854
96	Gap junction_Homo sapiens_hsa04540	0.30570735
97	Amphetamine addiction_Homo sapiens_hsa05031	0.30237248
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.29248217
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29067894
100	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.27955742

AP1B1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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