AP1G2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.16260088
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.16260088
3antigen processing and presentation of endogenous antigen (GO:0019883)5.87321958
4positive regulation of gamma-delta T cell activation (GO:0046645)5.78984635
5ribosomal small subunit assembly (GO:0000028)4.74094174
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37226413
7regulation of gamma-delta T cell activation (GO:0046643)4.17330618
8regulation of B cell receptor signaling pathway (GO:0050855)4.16514882
9regulation of gamma-delta T cell differentiation (GO:0045586)4.13353295
10negative regulation of erythrocyte differentiation (GO:0045647)4.09285175
11interferon-gamma production (GO:0032609)3.82473820
12mannose metabolic process (GO:0006013)3.77695174
13regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.77398698
14detection of bacterium (GO:0016045)3.74240622
15viral transcription (GO:0019083)3.63428902
16positive regulation of B cell differentiation (GO:0045579)3.55000546
17positive thymic T cell selection (GO:0045059)3.54377650
18B cell receptor signaling pathway (GO:0050853)3.52424858
19tolerance induction (GO:0002507)3.50735307
20positive regulation of granulocyte differentiation (GO:0030854)3.50465742
21detection of other organism (GO:0098543)3.49577599
22antigen processing and presentation via MHC class Ib (GO:0002475)3.45113293
23negative thymic T cell selection (GO:0045060)3.44640343
24translational termination (GO:0006415)3.43330102
25regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.42935753
26negative T cell selection (GO:0043383)3.41501616
27regulation of B cell differentiation (GO:0045577)3.40570618
28response to type I interferon (GO:0034340)3.33666957
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.33542154
30type I interferon signaling pathway (GO:0060337)3.30004541
31cellular response to type I interferon (GO:0071357)3.30004541
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.28627127
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28137020
34regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19566555
35response to interleukin-15 (GO:0070672)3.18585795
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17947674
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17872878
38T cell migration (GO:0072678)3.16733298
39negative regulation of T cell mediated immunity (GO:0002710)3.15885683
40neutrophil activation involved in immune response (GO:0002283)3.15697691
41leukocyte aggregation (GO:0070486)3.14466999
42negative regulation of phagocytosis (GO:0050765)3.13498656
43NIK/NF-kappaB signaling (GO:0038061)3.13276326
44negative regulation of leukocyte mediated immunity (GO:0002704)3.12207353
45mucosal-associated lymphoid tissue development (GO:0048537)3.11092497
46Peyers patch development (GO:0048541)3.11092497
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08105177
48germinal center formation (GO:0002467)3.06904900
49thymic T cell selection (GO:0045061)3.05947483
50negative regulation of cell killing (GO:0031342)3.05579917
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.05579917
52positive regulation of antigen processing and presentation (GO:0002579)3.04425512
53negative regulation of innate immune response (GO:0045824)3.00003209
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99559319
55mature B cell differentiation (GO:0002335)2.99066592
56T cell homeostasis (GO:0043029)2.98975690
57protein targeting to ER (GO:0045047)2.98020969
58regulation of regulatory T cell differentiation (GO:0045589)2.97967040
59immunoglobulin mediated immune response (GO:0016064)2.97951019
60translational elongation (GO:0006414)2.97444133
61cotranslational protein targeting to membrane (GO:0006613)2.96914218
62ribosomal small subunit biogenesis (GO:0042274)2.95532237
63regulation of T cell receptor signaling pathway (GO:0050856)2.95336814
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91862061
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.91862061
66modulation by symbiont of host immune response (GO:0052553)2.91862061
67positive regulation by symbiont of host defense response (GO:0052509)2.91862061
68modulation by symbiont of host defense response (GO:0052031)2.91862061
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91862061
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91706762
71telomere maintenance via semi-conservative replication (GO:0032201)2.91175780
72mature B cell differentiation involved in immune response (GO:0002313)2.90986971
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89748582
74mast cell activation (GO:0045576)2.89202328
75defense response to protozoan (GO:0042832)2.88808662
76regulation of granulocyte differentiation (GO:0030852)2.87199139
77myeloid dendritic cell activation (GO:0001773)2.87154160
78cellular response to interleukin-15 (GO:0071350)2.86940199
79regulation of mast cell degranulation (GO:0043304)2.85018822
80negative regulation of interleukin-12 production (GO:0032695)2.84005794
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83065602
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82635810
83DNA strand elongation involved in DNA replication (GO:0006271)2.81986641
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81161816
85regulation of T cell mediated cytotoxicity (GO:0001914)2.80474873
86positive regulation of isotype switching (GO:0045830)2.79770679
87T cell selection (GO:0045058)2.78788614
88antigen receptor-mediated signaling pathway (GO:0050851)2.78377634
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78133504
90T cell receptor signaling pathway (GO:0050852)2.78106038
91cellular response to interferon-beta (GO:0035458)2.77352693
92protein localization to endoplasmic reticulum (GO:0070972)2.77263078
93response to peptidoglycan (GO:0032494)2.76133001
94regulation of antigen processing and presentation (GO:0002577)2.76015837
95response to protozoan (GO:0001562)2.75406267
96lymphocyte homeostasis (GO:0002260)2.74749628
97regulation of natural killer cell mediated immunity (GO:0002715)2.73979540
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.73979540
99DNA strand elongation (GO:0022616)2.71450954
100positive T cell selection (GO:0043368)2.71253203
101viral life cycle (GO:0019058)2.71152568
102response to interferon-beta (GO:0035456)2.70657897
103cellular response to zinc ion (GO:0071294)2.67937775
104macrophage activation involved in immune response (GO:0002281)2.66886397
105positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66432871
106response to muramyl dipeptide (GO:0032495)2.66418285
107positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65142851
108regulation of interleukin-2 biosynthetic process (GO:0045076)2.63395351
109regulation of leukocyte degranulation (GO:0043300)2.63331617
110regulation of tolerance induction (GO:0002643)2.63303749
111interferon-gamma-mediated signaling pathway (GO:0060333)2.62220206
112negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.61776758
113regulation of interferon-beta biosynthetic process (GO:0045357)2.61754959
114pinocytosis (GO:0006907)2.60994169
115detection of external biotic stimulus (GO:0098581)2.60385572
116maturation of SSU-rRNA (GO:0030490)2.60320874
117regulation of alpha-beta T cell proliferation (GO:0046640)2.59652888
118regulation of response to interferon-gamma (GO:0060330)2.59613293
119regulation of T cell tolerance induction (GO:0002664)2.59527607
120B cell mediated immunity (GO:0019724)2.59447567
121regulation of ARF GTPase activity (GO:0032312)2.59113127
122telomere maintenance via recombination (GO:0000722)2.57944263
123negative regulation of T-helper cell differentiation (GO:0045623)2.56971480
124negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.56971480
125positive regulation of interleukin-4 production (GO:0032753)2.56774005
126regulation of necroptotic process (GO:0060544)2.56460182
127positive regulation of interferon-alpha production (GO:0032727)2.56053644
128B cell homeostasis (GO:0001782)2.55781884
129regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.55481828
130regulation of mast cell activation involved in immune response (GO:0033006)2.54447314
131regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.53632722
132positive regulation of humoral immune response (GO:0002922)2.53349567
133lymph node development (GO:0048535)2.53080008
134actin nucleation (GO:0045010)2.53069153
135cellular protein complex disassembly (GO:0043624)2.52854380
136negative regulation of cytokine production involved in immune response (GO:0002719)2.52434932
137negative regulation of bone resorption (GO:0045779)2.52004395
138neutrophil activation (GO:0042119)2.51667124
139natural killer cell activation (GO:0030101)2.50478029
140positive regulation of B cell activation (GO:0050871)2.50354612
141interferon-gamma secretion (GO:0072643)2.49888701
142positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.49538658
143positive regulation of DNA recombination (GO:0045911)2.47518777
144positive regulation of B cell mediated immunity (GO:0002714)2.47310865
145T cell costimulation (GO:0031295)2.47216770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.86572934
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.47305908
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42202597
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15132843
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.13285723
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02435246
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.91633868
8MYC_22102868_ChIP-Seq_BL_Human2.83077059
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.77465956
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62083574
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58354209
12VDR_21846776_ChIP-Seq_THP-1_Human2.53014968
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46601703
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40567451
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32488964
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.32288040
17LXR_22292898_ChIP-Seq_THP-1_Human2.25291186
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23178890
19SCL_19346495_ChIP-Seq_HPC-7_Human2.19431102
20KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17763286
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17112548
22MAF_26560356_Chip-Seq_TH1_Human2.15812036
23MYB_26560356_Chip-Seq_TH2_Human2.15681303
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.13858770
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12489520
26SPI1_23547873_ChIP-Seq_NB4_Human2.07998966
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.06837564
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03419619
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.02167864
30MYB_26560356_Chip-Seq_TH1_Human1.98933409
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.98806047
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98145185
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98054247
34KDM2B_26808549_Chip-Seq_DND41_Human1.97175475
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95791617
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93724566
37MYC_18555785_ChIP-Seq_MESCs_Mouse1.86131077
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.84630203
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84446490
40UTX_26944678_Chip-Seq_JUKART_Human1.83941368
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82536328
42VDR_24763502_ChIP-Seq_THP-1_Human1.81706171
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77706845
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76751540
45RUNX_20019798_ChIP-Seq_JUKART_Human1.73070754
46* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72186153
47GATA1_22025678_ChIP-Seq_K562_Human1.71602978
48CIITA_25753668_ChIP-Seq_RAJI_Human1.71409595
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.65847766
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65190540
51P68_20966046_ChIP-Seq_HELA_Human1.62857402
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59197578
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.57812816
54BCOR_27268052_Chip-Seq_Bcells_Human1.55037417
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.54677301
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54131405
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53536113
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53277324
59TCF7_22412390_ChIP-Seq_EML_Mouse1.52643801
60* MAF_26560356_Chip-Seq_TH2_Human1.51981186
61RACK7_27058665_Chip-Seq_MCF-7_Human1.50786263
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47373374
63GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.44158825
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42334374
65VDR_23849224_ChIP-Seq_CD4+_Human1.40129070
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38114513
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37036469
68FOXP3_21729870_ChIP-Seq_TREG_Human1.36703970
69* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35862386
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35419602
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.35040323
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34504766
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.32818292
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32195367
75SPI1_23127762_ChIP-Seq_K562_Human1.30328064
76SMC4_20622854_ChIP-Seq_HELA_Human1.29071739
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28523367
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28155925
79GATA3_27048872_Chip-Seq_THYMUS_Human1.26421755
80* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22635006
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21672396
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21504520
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20403889
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19761838
85NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19665080
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.19518076
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.19137991
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18546583
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.18213041
90TET1_21451524_ChIP-Seq_MESCs_Mouse1.17807733
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16945444
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16120123
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15878786
94XRN2_22483619_ChIP-Seq_HELA_Human1.15616324
95PU_27001747_Chip-Seq_BMDM_Mouse1.15178800
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15147870
97GATA1_19941826_ChIP-Seq_K562_Human1.15073382
98E2F1_20622854_ChIP-Seq_HELA_Human1.14622387
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.14501169
100RXR_22158963_ChIP-Seq_LIVER_Mouse1.12797763
101JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12560455
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.11706814
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10789310
104MYC_19030024_ChIP-ChIP_MESCs_Mouse1.10354284
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09677472
106PHF8_20622854_ChIP-Seq_HELA_Human1.09618087
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.08002703
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07767501
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06616659
110CREB1_26743006_Chip-Seq_LNCaP_Human1.05607803
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.03894505
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03861070
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02992140
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02285088
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02280927
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.02201010
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02009176
118FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01937079
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00798005
120TP63_17297297_ChIP-ChIP_HaCaT_Human0.97787856
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97667836
122ELK3_25401928_ChIP-Seq_HUVEC_Human0.96003267
123DCP1A_22483619_ChIP-Seq_HELA_Human0.95510590
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95380370
125PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94855400
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94846348
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94651665
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.94289329
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91536626
130GATA3_26560356_Chip-Seq_TH2_Human0.90052611
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89983149
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88609840
133TFEB_21752829_ChIP-Seq_HELA_Human0.88223163
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87423011
135BCL6_27268052_Chip-Seq_Bcells_Human0.87091389
136NCOR1_26117541_ChIP-Seq_K562_Human0.86511682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.16649809
2MP0003763_abnormal_thymus_physiology3.12871587
3MP0000685_abnormal_immune_system3.12236016
4MP0005671_abnormal_response_to3.11746969
5MP0001800_abnormal_humoral_immune3.03886095
6MP0005387_immune_system_phenotype2.93127660
7MP0001790_abnormal_immune_system2.93127660
8MP0002396_abnormal_hematopoietic_system2.87239942
9MP0005000_abnormal_immune_tolerance2.61585674
10MP0009785_altered_susceptibility_to2.60140283
11MP0002452_abnormal_antigen_presenting2.58332327
12MP0002723_abnormal_immune_serum2.53799724
13MP0002420_abnormal_adaptive_immunity2.52404580
14MP0001873_stomach_inflammation2.51312291
15MP0001819_abnormal_immune_cell2.50015047
16MP0002398_abnormal_bone_marrow2.49904289
17MP0003436_decreased_susceptibility_to2.47826971
18MP0005025_abnormal_response_to2.47703519
19MP0002148_abnormal_hypersensitivity_rea2.38332879
20MP0003303_peritoneal_inflammation2.22345377
21MP0002166_altered_tumor_susceptibility2.21294156
22MP0010155_abnormal_intestine_physiology2.19551170
23MP0000716_abnormal_immune_system2.19107080
24MP0002419_abnormal_innate_immunity2.15405358
25MP0002405_respiratory_system_inflammati2.10358764
26MP0009333_abnormal_splenocyte_physiolog2.08010048
27MP0000689_abnormal_spleen_morphology2.04402331
28MP0002722_abnormal_immune_system2.04055473
29MP0005464_abnormal_platelet_physiology1.96576046
30MP0003866_abnormal_defecation1.93222184
31MP0000490_abnormal_crypts_of1.92947050
32MP0004947_skin_inflammation1.91414321
33MP0002429_abnormal_blood_cell1.88916424
34MP0002006_tumorigenesis1.88157404
35MP0004808_abnormal_hematopoietic_stem1.88139355
36MP0003300_gastrointestinal_ulcer1.86415813
37MP0003724_increased_susceptibility_to1.84956217
38MP0000703_abnormal_thymus_morphology1.80927741
39MP0005397_hematopoietic_system_phenotyp1.79736031
40MP0001545_abnormal_hematopoietic_system1.79736031
41MP0008260_abnormal_autophagy1.77775056
42MP0001845_abnormal_inflammatory_respons1.73901947
43MP0005174_abnormal_tail_pigmentation1.67527639
44MP0000465_gastrointestinal_hemorrhage1.60723172
45MP0008057_abnormal_DNA_replication1.57954422
46MP0001853_heart_inflammation1.53537106
47MP0005451_abnormal_body_composition1.46833272
48MP0006082_CNS_inflammation1.46313987
49MP0005360_urolithiasis1.43242629
50MP0005075_abnormal_melanosome_morpholog1.36562672
51MP0009764_decreased_sensitivity_to1.33148761
52MP0009278_abnormal_bone_marrow1.33007665
53MP0005310_abnormal_salivary_gland1.32611701
54MP0003693_abnormal_embryo_hatching1.30505218
55MP0008469_abnormal_protein_level1.27423576
56MP0003183_abnormal_peptide_metabolism1.22269791
57MP0002132_abnormal_respiratory_system1.22171501
58MP0010094_abnormal_chromosome_stability1.21679633
59MP0005058_abnormal_lysosome_morphology1.20906049
60MP0000858_altered_metastatic_potential1.19640153
61MP0004510_myositis1.17967146
62MP0008058_abnormal_DNA_repair1.15410745
63MP0002019_abnormal_tumor_incidence1.13955621
64MP0003077_abnormal_cell_cycle1.13073635
65MP0001348_abnormal_lacrimal_gland1.12001108
66MP0005365_abnormal_bile_salt1.09748270
67MP0002933_joint_inflammation1.08544296
68MP0003111_abnormal_nucleus_morphology1.07217853
69MP0001533_abnormal_skeleton_physiology1.03227580
70MP0003045_fibrosis1.02424755
71MP0001851_eye_inflammation1.02219030
72MP0001663_abnormal_digestive_system0.98525448
73MP0010352_gastrointestinal_tract_polyps0.96552102
74MP0008007_abnormal_cellular_replicative0.95581412
75MP0002998_abnormal_bone_remodeling0.95165672
76MP0010307_abnormal_tumor_latency0.94902081
77MP0003172_abnormal_lysosome_physiology0.94508588
78MP0004957_abnormal_blastocyst_morpholog0.90586692
79MP0001765_abnormal_ion_homeostasis0.89666601
80MP0010329_abnormal_lipoprotein_level0.88132483
81MP0005409_darkened_coat_color0.87699035
82MP0001986_abnormal_taste_sensitivity0.87051325
83MP0003448_altered_tumor_morphology0.86859897
84MP0002095_abnormal_skin_pigmentation0.85951080
85MP0003191_abnormal_cellular_cholesterol0.84752902
86MP0009763_increased_sensitivity_to0.84274029
87MP0001849_ear_inflammation0.81795426
88MP0000371_diluted_coat_color0.80328043
89MP0008875_abnormal_xenobiotic_pharmacok0.80112530
90MP0009840_abnormal_foam_cell0.78877627
91MP0005166_decreased_susceptibility_to0.77803513
92MP0003075_altered_response_to0.74573345
93MP0000477_abnormal_intestine_morphology0.72885938
94MP0002139_abnormal_hepatobiliary_system0.72746593
95MP0002928_abnormal_bile_duct0.72614239
96MP0003656_abnormal_erythrocyte_physiolo0.72566987
97MP0000313_abnormal_cell_death0.72318214
98MP0004264_abnormal_extraembryonic_tissu0.72270738
99MP0002138_abnormal_hepatobiliary_system0.71486208
100MP0004381_abnormal_hair_follicle0.71385224
101MP0000015_abnormal_ear_pigmentation0.70932374
102MP0005076_abnormal_cell_differentiation0.70899270
103MP0009643_abnormal_urine_homeostasis0.70836478
104MP0000678_abnormal_parathyroid_gland0.70657882
105MP0002693_abnormal_pancreas_physiology0.70311134
106MP0009765_abnormal_xenobiotic_induced0.70157292
107MP0000604_amyloidosis0.68462686
108MP0002277_abnormal_respiratory_mucosa0.66230432
109MP0005670_abnormal_white_adipose0.65664431
110MP0000609_abnormal_liver_physiology0.64930512
111MP0000343_altered_response_to0.63862414
112MP0002136_abnormal_kidney_physiology0.63154295
113MP0002118_abnormal_lipid_homeostasis0.62976524
114MP0001764_abnormal_homeostasis0.62796321
115MP0003453_abnormal_keratinocyte_physiol0.62353788
116MP0001191_abnormal_skin_condition0.62067115
117MP0004185_abnormal_adipocyte_glucose0.62018448
118MP0001216_abnormal_epidermal_layer0.60696929
119MP0009642_abnormal_blood_homeostasis0.60321908
120MP0009931_abnormal_skin_appearance0.58878585
121MP0005023_abnormal_wound_healing0.58754502
122MP0008004_abnormal_stomach_pH0.58643978
123MP0005390_skeleton_phenotype0.58126889
124MP0002009_preneoplasia0.56827994
125MP0001666_abnormal_nutrient_absorption0.56361598
126MP0008874_decreased_physiological_sensi0.55975633
127MP0003795_abnormal_bone_structure0.54911295
128MP0003252_abnormal_bile_duct0.54687052
129MP0000598_abnormal_liver_morphology0.54346557

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.30118101
2Myositis (HP:0100614)4.29396111
3Chronic otitis media (HP:0000389)4.15800391
4Elevated erythrocyte sedimentation rate (HP:0003565)4.13302271
5Thrombocytosis (HP:0001894)4.11180291
6Recurrent abscess formation (HP:0002722)4.08760408
7Eczematoid dermatitis (HP:0000976)4.03935410
8Recurrent viral infections (HP:0004429)4.03904062
9Recurrent fungal infections (HP:0002841)3.90888239
10Recurrent bronchitis (HP:0002837)3.76348215
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.61514156
12Abnormal number of erythroid precursors (HP:0012131)3.50268121
13Recurrent bacterial skin infections (HP:0005406)3.47197460
14Pustule (HP:0200039)3.45147453
15Abnormality of T cells (HP:0002843)3.44502945
16Abnormality of cells of the erythroid lineage (HP:0012130)3.40611150
17Panhypogammaglobulinemia (HP:0003139)3.40231151
18Agammaglobulinemia (HP:0004432)3.39628731
19Abnormality of T cell physiology (HP:0011840)3.36476290
20T lymphocytopenia (HP:0005403)3.35654003
21Meningitis (HP:0001287)3.35196685
22Recurrent cutaneous fungal infections (HP:0011370)3.30504477
23Chronic mucocutaneous candidiasis (HP:0002728)3.30504477
24Abnormality of T cell number (HP:0011839)3.28435039
25Nasal polyposis (HP:0100582)3.23612993
26Inflammation of the large intestine (HP:0002037)3.20315968
27Abnormality of B cell number (HP:0010975)3.18851152
28B lymphocytopenia (HP:0010976)3.18851152
29Reticulocytopenia (HP:0001896)3.15965099
30Gastrointestinal inflammation (HP:0004386)3.14672923
31Retrobulbar optic neuritis (HP:0100654)3.12527186
32Optic neuritis (HP:0100653)3.12527186
33Autoimmune thrombocytopenia (HP:0001973)3.12301750
34Petechiae (HP:0000967)3.11636170
35Orchitis (HP:0100796)3.11079963
36Gastrointestinal infarctions (HP:0005244)3.10476568
37Lymphopenia (HP:0001888)2.99391262
38IgG deficiency (HP:0004315)2.95872220
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.95114564
40Vasculitis (HP:0002633)2.93372797
41Cellulitis (HP:0100658)2.91715745
42Recurrent skin infections (HP:0001581)2.87281052
43Mediastinal lymphadenopathy (HP:0100721)2.86312006
44Abnormality of the nasal mucosa (HP:0000433)2.85801431
45Vacuolated lymphocytes (HP:0001922)2.84849560
46Colitis (HP:0002583)2.83036214
47Prolonged bleeding time (HP:0003010)2.78236804
48Abnormality of the fingertips (HP:0001211)2.75290642
49Deep venous thrombosis (HP:0002625)2.75235564
50Dysostosis multiplex (HP:0000943)2.70397970
51Granulocytopenia (HP:0001913)2.66339555
52Combined immunodeficiency (HP:0005387)2.64153399
53Increased IgE level (HP:0003212)2.62250423
54Severe combined immunodeficiency (HP:0004430)2.59443630
55Encephalitis (HP:0002383)2.59067767
56Interstitial pulmonary disease (HP:0006530)2.57700978
57IgA deficiency (HP:0002720)2.54152585
58Seborrheic dermatitis (HP:0001051)2.53014694
59Hemorrhage of the eye (HP:0011885)2.52986887
60Chronic diarrhea (HP:0002028)2.50939824
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50920866
62Abnormality of polysaccharide metabolism (HP:0011012)2.50920866
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50920866
64Urinary glycosaminoglycan excretion (HP:0003541)2.50774442
65Mucopolysacchariduria (HP:0008155)2.50774442
66Recurrent sinusitis (HP:0011108)2.50408236
67Stomatitis (HP:0010280)2.50395390
68Lymphoma (HP:0002665)2.49190977
69Abnormality of macrophages (HP:0004311)2.47710391
70Obstructive lung disease (HP:0006536)2.44555262
71Chronic obstructive pulmonary disease (HP:0006510)2.44555262
72Hemoptysis (HP:0002105)2.44377600
73Pulmonary infiltrates (HP:0002113)2.44111619
74Eosinophilia (HP:0001880)2.43608330
75Gastrointestinal stroma tumor (HP:0100723)2.41004786
76Epistaxis (HP:0000421)2.40236697
77Pallor (HP:0000980)2.39831248
78Periodontitis (HP:0000704)2.39004369
79Joint swelling (HP:0001386)2.36572817
80Purpura (HP:0000979)2.34284145
81Papilledema (HP:0001085)2.30868496
82Thyroiditis (HP:0100646)2.30143011
83Cheilitis (HP:0100825)2.29125715
84Abnormal platelet function (HP:0011869)2.29114161
85Impaired platelet aggregation (HP:0003540)2.29114161
86Increased IgM level (HP:0003496)2.28768834
87Pulmonary embolism (HP:0002204)2.27845993
88Keratoconjunctivitis sicca (HP:0001097)2.27692347
89Leukocytosis (HP:0001974)2.27590028
90Spontaneous hematomas (HP:0007420)2.27415480
91Hypochromic anemia (HP:0001931)2.25665831
92Autoimmune hemolytic anemia (HP:0001890)2.24656100
93Abnormality of the pleura (HP:0002103)2.22809748
94Abnormality of eosinophils (HP:0001879)2.21273364
95Joint hemorrhage (HP:0005261)2.20646017
96J-shaped sella turcica (HP:0002680)2.18940188
97Broad face (HP:0000283)2.18328841
98Chronic sinusitis (HP:0011109)2.15615907
99Keratoconjunctivitis (HP:0001096)2.15005070
100Urticaria (HP:0001025)2.12872468
101Papilloma (HP:0012740)2.12620591
102Verrucae (HP:0200043)2.12620591
103Acute hepatic failure (HP:0006554)2.12354035
104Hypoplasia of the thymus (HP:0000778)2.11090928
105Hypergammaglobulinemia (HP:0010702)2.09754408
106Skin ulcer (HP:0200042)2.09212823
107Recurrent gram-negative bacterial infections (HP:0005420)2.08696810
108Leukopenia (HP:0001882)2.08388277
109Systemic lupus erythematosus (HP:0002725)2.07987515
110Arterial thrombosis (HP:0004420)2.07519181
111Osteomyelitis (HP:0002754)2.07490551
112Gingival bleeding (HP:0000225)2.07019857
113Gingivitis (HP:0000230)2.06026733
114Abnormality of the prostate (HP:0008775)2.04710418
115Microcytic anemia (HP:0001935)2.03709375
116Bronchitis (HP:0012387)2.02704869
117Myelodysplasia (HP:0002863)2.00752398
118Reduced antithrombin III activity (HP:0001976)1.99266788
119Emphysema (HP:0002097)1.98929507
120Increased serum ferritin (HP:0003281)1.98428294
121Chest pain (HP:0100749)1.97767955
122Neutropenia (HP:0001875)1.96630689
123Restrictive lung disease (HP:0002091)1.96137536
124Fatigue (HP:0012378)1.96093684
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.95236024
126Villous atrophy (HP:0011473)1.93590550
127Abnormality of small intestinal villus morphology (HP:0011472)1.93590550
128Increased cerebral lipofuscin (HP:0011813)1.93515674
129Menorrhagia (HP:0000132)1.93274881
130Polygenic inheritance (HP:0010982)1.91477355
131Malnutrition (HP:0004395)1.89664556
132Skin rash (HP:0000988)1.89478281

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.22815986
2TXK3.24797353
3TYK22.75302357
4ZAP702.34298638
5MAP3K142.32462219
6JAK32.27239573
7EEF2K2.19851158
8IRAK42.18575577
9KIT2.08649396
10BLK2.07712299
11TBK12.07673873
12STK102.01599960
13BTK2.00770585
14IKBKE1.99484432
15GRK61.95419525
16SIK11.85682783
17PRPF4B1.83683527
18TEC1.82745403
19SYK1.79165800
20NME21.72784808
21FLT31.71213814
22MAP3K131.67867140
23ERN11.67429494
24STK161.63074462
25ZAK1.60646284
26TAOK31.59763294
27ITK1.58523214
28IRAK31.54776278
29JAK11.50949279
30CSF1R1.49024736
31MAP3K101.47709836
32IKBKB1.46217738
33PIM21.41310438
34MST41.38651676
35LCK1.34719822
36SMG11.32809370
37FGFR41.30605145
38CSK1.28344881
39MARK21.22088170
40PIM11.21164385
41LRRK21.19604151
42RPS6KA41.17945527
43MAP2K31.13420257
44CDC42BPA1.13349159
45TLK11.10588563
46HCK1.10488065
47PASK1.09862679
48MATK1.09595538
49LYN1.09436076
50CHUK1.07469586
51RIPK11.02843250
52PKN21.02265025
53TGFBR21.02089640
54KDR0.99196090
55PRKD20.98956001
56PDK10.97609093
57CLK10.97491159
58TGFBR10.96501144
59NEK20.92139253
60NLK0.90911241
61CAMKK10.90704096
62FGR0.90259136
63FES0.89561364
64CDK120.87474959
65MAP3K30.87220460
66MAP2K20.86047456
67RIPK40.85864733
68MAP3K10.84214383
69RPS6KB20.83314276
70MAP3K70.82480804
71ICK0.82355194
72SIK20.81373196
73PDPK10.79304222
74CDK40.79236083
75MST1R0.75304144
76PRKCH0.75273121
77MAPK120.73492379
78MAPK110.71323538
79STK40.70219231
80ATR0.69139098
81BMX0.65470664
82HIPK20.64323351
83TAOK10.64255159
84TRPM70.63552988
85MARK30.61919625
86TTK0.61542419
87JAK20.59501041
88EIF2AK30.59323911
89PRKCQ0.58567069
90MAP3K60.57789537
91FGFR30.57109781
92PRKG20.54626395
93FYN0.53145743
94TNK20.52708221
95MAP2K60.52376678
96RET0.52336153
97AURKB0.51419463
98SCYL20.50882759
99TESK20.48946300
100MAP3K110.47936738
101VRK10.47883050
102MAPK70.46862554
103RPS6KA20.46601061
104EIF2AK10.46536987
105MAPKAPK30.46506434
106EPHB10.45581192
107CDC70.44395894
108MAP3K80.44048736
109DAPK20.43268241
110EPHA20.42465968
111MAPK30.40760173
112CDK70.40717712
113CDK90.40438916
114RPS6KA60.40365643
115CDK60.39864350
116PTK60.39502327
117DYRK1B0.37921310
118MAPK150.37339842
119CCNB10.37261091
120MAPKAPK20.37259367
121TRIB30.35205831
122SIK30.35154415
123WEE10.34553686
124ABL10.34508945
125MAPK40.33714135
126RPS6KC10.33281421
127RPS6KL10.33281421
128BCKDK0.33118944
129STK380.32593597
130TYRO30.31894497
131SGK30.31870820
132DAPK10.31866483
133PRKCD0.31487838
134PRKD10.28230218
135FGFR20.27818152
136MTOR0.26447403
137MAP3K20.26132948

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.88602479
2DNA replication_Homo sapiens_hsa030303.23927182
3Ribosome_Homo sapiens_hsa030102.80836318
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.48289144
5Leishmaniasis_Homo sapiens_hsa051402.29004837
6B cell receptor signaling pathway_Homo sapiens_hsa046622.28555388
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.26643654
8Measles_Homo sapiens_hsa051622.23046007
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23007811
10Mismatch repair_Homo sapiens_hsa034302.17449034
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14193910
12Hematopoietic cell lineage_Homo sapiens_hsa046402.08022555
13Base excision repair_Homo sapiens_hsa034102.07099196
14Antigen processing and presentation_Homo sapiens_hsa046122.04654809
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91182991
16Herpes simplex infection_Homo sapiens_hsa051681.82313604
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79878558
18Allograft rejection_Homo sapiens_hsa053301.79380105
19T cell receptor signaling pathway_Homo sapiens_hsa046601.70608571
20Osteoclast differentiation_Homo sapiens_hsa043801.67251575
21Homologous recombination_Homo sapiens_hsa034401.61315768
22Other glycan degradation_Homo sapiens_hsa005111.59761172
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56960284
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48345630
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47551677
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.45551191
27Influenza A_Homo sapiens_hsa051641.34794949
28Non-homologous end-joining_Homo sapiens_hsa034501.33363416
29Apoptosis_Homo sapiens_hsa042101.30496497
30Legionellosis_Homo sapiens_hsa051341.30307330
31One carbon pool by folate_Homo sapiens_hsa006701.24061323
32Graft-versus-host disease_Homo sapiens_hsa053321.23917746
33p53 signaling pathway_Homo sapiens_hsa041151.23050385
34Toxoplasmosis_Homo sapiens_hsa051451.20332977
35Spliceosome_Homo sapiens_hsa030401.17807783
36Acute myeloid leukemia_Homo sapiens_hsa052211.17336359
37Nucleotide excision repair_Homo sapiens_hsa034201.16875618
38Hepatitis B_Homo sapiens_hsa051611.15622939
39Non-small cell lung cancer_Homo sapiens_hsa052231.15148652
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.14585337
41Caffeine metabolism_Homo sapiens_hsa002321.10473998
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09264748
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07642639
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.06557934
45Shigellosis_Homo sapiens_hsa051311.05168461
46Pyrimidine metabolism_Homo sapiens_hsa002401.05167539
47Pertussis_Homo sapiens_hsa051331.04725810
48Folate biosynthesis_Homo sapiens_hsa007901.04159129
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02444499
50Fanconi anemia pathway_Homo sapiens_hsa034601.01958192
51VEGF signaling pathway_Homo sapiens_hsa043701.00431998
52Autoimmune thyroid disease_Homo sapiens_hsa053200.98764069
53Tuberculosis_Homo sapiens_hsa051520.98734074
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96500295
55Epstein-Barr virus infection_Homo sapiens_hsa051690.96195404
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91757718
57TNF signaling pathway_Homo sapiens_hsa046680.90507677
58Cell cycle_Homo sapiens_hsa041100.88540581
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.88115267
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87604930
61Staphylococcus aureus infection_Homo sapiens_hsa051500.86942660
62Viral myocarditis_Homo sapiens_hsa054160.86685942
63Asthma_Homo sapiens_hsa053100.86222477
64HTLV-I infection_Homo sapiens_hsa051660.85977319
65Chemokine signaling pathway_Homo sapiens_hsa040620.85697434
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85115067
67Pentose phosphate pathway_Homo sapiens_hsa000300.83370615
68Choline metabolism in cancer_Homo sapiens_hsa052310.82441075
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81433825
70Sulfur relay system_Homo sapiens_hsa041220.81024360
71RNA degradation_Homo sapiens_hsa030180.80192846
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80004226
73Complement and coagulation cascades_Homo sapiens_hsa046100.78599799
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.78330783
75Inositol phosphate metabolism_Homo sapiens_hsa005620.77980096
76Hepatitis C_Homo sapiens_hsa051600.76737606
77Rheumatoid arthritis_Homo sapiens_hsa053230.76204973
78Viral carcinogenesis_Homo sapiens_hsa052030.76113470
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75543670
80Chronic myeloid leukemia_Homo sapiens_hsa052200.73966925
81Platelet activation_Homo sapiens_hsa046110.73354728
82Insulin resistance_Homo sapiens_hsa049310.73297484
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.72911958
84mTOR signaling pathway_Homo sapiens_hsa041500.71159026
85Galactose metabolism_Homo sapiens_hsa000520.70892214
86Malaria_Homo sapiens_hsa051440.70451232
87African trypanosomiasis_Homo sapiens_hsa051430.68872762
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68538882
89Small cell lung cancer_Homo sapiens_hsa052220.67107236
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.64874510
91Prolactin signaling pathway_Homo sapiens_hsa049170.63785099
92ABC transporters_Homo sapiens_hsa020100.63142761
93GnRH signaling pathway_Homo sapiens_hsa049120.62706793
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61479684
95Endocytosis_Homo sapiens_hsa041440.59568366
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.57327871
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56491223
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56487566
99Vitamin digestion and absorption_Homo sapiens_hsa049770.54106073
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53563251
101RNA polymerase_Homo sapiens_hsa030200.53444582
102Pancreatic cancer_Homo sapiens_hsa052120.51482171
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50441422
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49574980
105Salmonella infection_Homo sapiens_hsa051320.47805711
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.47288009
107Protein export_Homo sapiens_hsa030600.47254768
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46658644
109Glycerolipid metabolism_Homo sapiens_hsa005610.46192372
110RNA transport_Homo sapiens_hsa030130.45911618
111Notch signaling pathway_Homo sapiens_hsa043300.45463318
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45456412
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.45171998
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44979767
115Regulation of autophagy_Homo sapiens_hsa041400.43967101
116Proteasome_Homo sapiens_hsa030500.43481982
117Type I diabetes mellitus_Homo sapiens_hsa049400.43146599
118Lysine degradation_Homo sapiens_hsa003100.42426897
119N-Glycan biosynthesis_Homo sapiens_hsa005100.42026779
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41825886
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39238773
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38764080
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36625215
124Fructose and mannose metabolism_Homo sapiens_hsa000510.35148090
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33988546
126Purine metabolism_Homo sapiens_hsa002300.33288368
127Insulin signaling pathway_Homo sapiens_hsa049100.32819331
128* Lysosome_Homo sapiens_hsa041420.32725538
129Phagosome_Homo sapiens_hsa041450.31928397
130MAPK signaling pathway_Homo sapiens_hsa040100.31782046
131Systemic lupus erythematosus_Homo sapiens_hsa053220.31501889
132Thyroid cancer_Homo sapiens_hsa052160.31061751
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27533755
134Arachidonic acid metabolism_Homo sapiens_hsa005900.27462158
135Ether lipid metabolism_Homo sapiens_hsa005650.26706475
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25212992
137FoxO signaling pathway_Homo sapiens_hsa040680.24197690
138Long-term potentiation_Homo sapiens_hsa047200.23436041

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