AP1M2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)6.49302059
2COPI coating of Golgi vesicle (GO:0048205)5.37123558
3Golgi transport vesicle coating (GO:0048200)5.37123558
4interferon-gamma secretion (GO:0072643)5.03052424
5regulation of water loss via skin (GO:0033561)4.60189464
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.45715117
7multicellular organismal water homeostasis (GO:0050891)4.19725479
8hemidesmosome assembly (GO:0031581)4.15471149
9calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.14569376
10negative regulation of keratinocyte proliferation (GO:0010839)4.13793828
11desmosome organization (GO:0002934)4.05832112
12establishment of skin barrier (GO:0061436)4.03347392
13L-serine metabolic process (GO:0006563)3.98600725
14glandular epithelial cell differentiation (GO:0002067)3.91119289
15keratinocyte development (GO:0003334)3.72240955
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65241165
17maturation of SSU-rRNA (GO:0030490)3.58663830
18L-alpha-amino acid transmembrane transport (GO:1902475)3.57542576
19establishment of integrated proviral latency (GO:0075713)3.56681887
20water homeostasis (GO:0030104)3.53342928
21tight junction assembly (GO:0070830)3.49419363
22protein complex localization (GO:0031503)3.45741893
23protein retention in ER lumen (GO:0006621)3.41322787
24regulation of keratinocyte proliferation (GO:0010837)3.40555691
25columnar/cuboidal epithelial cell development (GO:0002066)3.39719524
26ribosome assembly (GO:0042255)3.35539317
27formation of translation preinitiation complex (GO:0001731)3.32614109
28establishment of apical/basal cell polarity (GO:0035089)3.29471696
29sphingosine metabolic process (GO:0006670)3.28405689
30pteridine-containing compound biosynthetic process (GO:0042559)3.25571744
31mitotic metaphase plate congression (GO:0007080)3.25568876
32vitamin transmembrane transport (GO:0035461)3.23411448
33GDP-mannose metabolic process (GO:0019673)3.22444910
34diol metabolic process (GO:0034311)3.21842827
35sphingoid metabolic process (GO:0046519)3.16556596
36intestinal absorption (GO:0050892)3.14465084
37regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.10895772
38purine nucleobase biosynthetic process (GO:0009113)3.10574821
39positive regulation of epidermal cell differentiation (GO:0045606)3.10506707
40homocysteine metabolic process (GO:0050667)3.10187554
41nucleobase biosynthetic process (GO:0046112)3.08644088
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.08072143
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06926223
44NADPH regeneration (GO:0006740)3.04469077
45renal absorption (GO:0070293)2.98875174
46gap junction assembly (GO:0016264)2.98526729
47copper ion transport (GO:0006825)2.96625730
48COPII vesicle coating (GO:0048208)2.91892062
49serine family amino acid biosynthetic process (GO:0009070)2.89752583
50signal transduction involved in regulation of gene expression (GO:0023019)2.89406467
51protein autoprocessing (GO:0016540)2.88180062
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87373300
53biotin metabolic process (GO:0006768)2.86909594
54trophectodermal cell differentiation (GO:0001829)2.86562019
55cellular copper ion homeostasis (GO:0006878)2.84915540
56folic acid transport (GO:0015884)2.82974091
57UDP-N-acetylglucosamine metabolic process (GO:0006047)2.82439335
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.82379320
59folic acid metabolic process (GO:0046655)2.82254172
60regulation of cardioblast differentiation (GO:0051890)2.82102590
61endocrine pancreas development (GO:0031018)2.82044426
62ribosomal large subunit biogenesis (GO:0042273)2.81730766
63proline biosynthetic process (GO:0006561)2.81636228
64protein targeting to ER (GO:0045047)2.79663115
65regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.79013804
66cotranslational protein targeting to membrane (GO:0006613)2.76536196
67primary alcohol catabolic process (GO:0034310)2.75982788
68pyrimidine-containing compound transmembrane transport (GO:0072531)2.75307400
69rRNA modification (GO:0000154)2.74675621
70cellular protein complex localization (GO:0034629)2.74528394
71regulation of cellular amino acid metabolic process (GO:0006521)2.73269124
72NADH metabolic process (GO:0006734)2.72170339
73epithelial cell-cell adhesion (GO:0090136)2.72168522
74establishment of viral latency (GO:0019043)2.71999015
75protein maturation by protein folding (GO:0022417)2.71218499
76blastocyst development (GO:0001824)2.70884499
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69894542
78negative regulation of cell fate commitment (GO:0010454)2.69504253
79nucleotide-sugar biosynthetic process (GO:0009226)2.68489703
80folic acid-containing compound biosynthetic process (GO:0009396)2.67771376
81establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66351267
82regulation of gene silencing by miRNA (GO:0060964)2.65211958
83regulation of gene silencing by RNA (GO:0060966)2.65211958
84regulation of posttranscriptional gene silencing (GO:0060147)2.65211958
85hepatocyte apoptotic process (GO:0097284)2.64448685
86pentose-phosphate shunt (GO:0006098)2.63983234
87protein localization to endoplasmic reticulum (GO:0070972)2.62481955
88proline metabolic process (GO:0006560)2.61909787
89metaphase plate congression (GO:0051310)2.60642627
90regulation of keratinocyte differentiation (GO:0045616)2.60231946
91response to food (GO:0032094)2.58326404
92proteasome assembly (GO:0043248)2.57568487
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.56594706
94positive regulation of keratinocyte differentiation (GO:0045618)2.56365481
95regulation of hippo signaling (GO:0035330)2.55750622
96lung-associated mesenchyme development (GO:0060484)2.55491729
97rRNA methylation (GO:0031167)2.53501160
98ribosomal small subunit assembly (GO:0000028)2.52537143
99erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.52425156
100L-phenylalanine metabolic process (GO:0006558)2.52425156
101translational initiation (GO:0006413)2.51642121
102positive regulation of cellular amine metabolic process (GO:0033240)2.50371305
103negative regulation of epidermal cell differentiation (GO:0045605)2.49928819
104cell-cell junction assembly (GO:0007043)2.49578322
105negative regulation of ligase activity (GO:0051352)2.49383370
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49383370
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.48394370
108termination of RNA polymerase III transcription (GO:0006386)2.48394370
109antibacterial humoral response (GO:0019731)2.47890247
110glucose catabolic process (GO:0006007)2.46664994
111viral transcription (GO:0019083)2.45405504
112histone H2A monoubiquitination (GO:0035518)2.45280307
113translational termination (GO:0006415)2.44325993
114vitamin transport (GO:0051180)2.44260322
115regulation of translational fidelity (GO:0006450)2.43014341
116negative regulation of cell fate specification (GO:0009996)2.42291302
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.42106077
118establishment or maintenance of monopolar cell polarity (GO:0061339)2.41188747
119establishment of monopolar cell polarity (GO:0061162)2.41188747
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.40501704
121ribosomal small subunit biogenesis (GO:0042274)2.40422228
122glutathione derivative metabolic process (GO:1901685)2.39901481
123glutathione derivative biosynthetic process (GO:1901687)2.39901481
124cardiac right ventricle morphogenesis (GO:0003215)2.39310699
125branching involved in mammary gland duct morphogenesis (GO:0060444)2.37244683
126nucleobase-containing small molecule interconversion (GO:0015949)2.37180878
127epithelial cell maturation (GO:0002070)2.37027380
128antimicrobial humoral response (GO:0019730)2.36161623
129glutathione biosynthetic process (GO:0006750)2.35245317
130tricarboxylic acid cycle (GO:0006099)2.35227934
131notochord development (GO:0030903)2.35029317
132translational elongation (GO:0006414)2.34951395
133regulation of translation in response to stress (GO:0043555)2.34760973
134phosphatidylserine acyl-chain remodeling (GO:0036150)2.34348119
135translation (GO:0006412)2.34221568
136activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.34186085
137peptide catabolic process (GO:0043171)2.33999288
138DNA strand elongation involved in DNA replication (GO:0006271)2.33422383
139sequestering of metal ion (GO:0051238)2.33343727
140IMP biosynthetic process (GO:0006188)2.32285598
141cysteine metabolic process (GO:0006534)2.32251061
142maternal placenta development (GO:0001893)2.32176199
143nodal signaling pathway (GO:0038092)2.32004079
144membrane budding (GO:0006900)2.31254886
145ribonucleoprotein complex biogenesis (GO:0022613)2.31096477
146histone arginine methylation (GO:0034969)2.29821623
147regulation of transforming growth factor beta2 production (GO:0032909)2.29773539
148DNA replication checkpoint (GO:0000076)2.29501951
149positive regulation of nuclease activity (GO:0032075)2.29387768
150regulation of epidermal cell differentiation (GO:0045604)2.28858594
151keratinocyte proliferation (GO:0043616)2.27970531
152intestinal cholesterol absorption (GO:0030299)2.27883399
153rRNA transcription (GO:0009303)2.26907305
154regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.26507787
155DNA strand elongation (GO:0022616)2.26195943
156ribosome biogenesis (GO:0042254)2.25028045
157trivalent inorganic anion homeostasis (GO:0072506)2.24803486
158phosphate ion homeostasis (GO:0055062)2.24803486
159morphogenesis of embryonic epithelium (GO:0016331)2.24190848
160negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.24118859
161modified amino acid transport (GO:0072337)2.23493623
162protein localization to kinetochore (GO:0034501)2.22154314
163regulation of mitochondrial translation (GO:0070129)2.20023203
164establishment or maintenance of apical/basal cell polarity (GO:0035088)2.17869773
165establishment or maintenance of bipolar cell polarity (GO:0061245)2.17869773
166mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.17866649
167establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.17586700
168pteridine-containing compound metabolic process (GO:0042558)2.17380929
169polarized epithelial cell differentiation (GO:0030859)2.17340270
170nonribosomal peptide biosynthetic process (GO:0019184)2.16546190
171sulfur amino acid catabolic process (GO:0000098)2.16315345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.08165155
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08981661
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.04154331
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97832013
5E2F7_22180533_ChIP-Seq_HELA_Human2.80542370
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.71572804
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67240757
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.51909569
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47599508
10AR_21909140_ChIP-Seq_LNCAP_Human2.43636159
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41093445
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.37959965
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32917793
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20077754
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.17516997
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.15628087
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11417106
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.08388268
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.06304984
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.04896733
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02305486
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.01858742
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97502773
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.96290546
25NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94249985
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93865500
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85359034
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84866963
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78841370
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78841370
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78841370
32ZNF263_19887448_ChIP-Seq_K562_Human1.75575601
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74923049
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70742090
35GATA4_25053715_ChIP-Seq_YYC3_Human1.68200004
36GATA6_25053715_ChIP-Seq_YYC3_Human1.66391091
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66228596
38XRN2_22483619_ChIP-Seq_HELA_Human1.62659535
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.57976927
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52229691
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51259229
42ATF3_27146783_Chip-Seq_COLON_Human1.49342674
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48592018
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48559124
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47783004
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46327874
47VDR_23849224_ChIP-Seq_CD4+_Human1.45892146
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45372906
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44112417
50EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.43637771
51GABP_19822575_ChIP-Seq_HepG2_Human1.43580259
52CDX2_20551321_ChIP-Seq_CACO-2_Human1.43302543
53DCP1A_22483619_ChIP-Seq_HELA_Human1.42760941
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.41990593
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41639542
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41307567
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.38823499
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37416426
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36051150
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35933368
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34538748
62ELF5_23300383_ChIP-Seq_T47D_Human1.32661305
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32132289
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31409711
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31214546
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30195728
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29844013
68KDM5A_27292631_Chip-Seq_BREAST_Human1.28015805
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27209308
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25759668
71CHD1_26751641_Chip-Seq_LNCaP_Human1.24608471
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22775295
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22605692
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21326208
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19409669
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18299880
77* SOX2_20726797_ChIP-Seq_SW620_Human1.17838269
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.17325788
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16850645
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16747212
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.15799427
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.15773589
83E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14458856
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14196537
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.13712596
86TTF2_22483619_ChIP-Seq_HELA_Human1.12912695
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12516860
88RACK7_27058665_Chip-Seq_MCF-7_Human1.11875237
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11531747
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11170555
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10364195
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10319432
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08324896
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07140437
95* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06638615
96TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.06076037
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05548304
98NANOG_16153702_ChIP-ChIP_HESCs_Human1.05062508
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04979431
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04511672
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.03512406
102TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02125962
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01669636
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00502331
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00440119
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00440119
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.00283040
108KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00098894
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99844629
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99799464
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98568204
112PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98415485
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.98130166
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98069024
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97369280
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96707372
117KAP1_27257070_Chip-Seq_ESCs_Mouse0.96660107
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96139775
119MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95467587
120FOXP3_21729870_ChIP-Seq_TREG_Human0.95450620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.84849986
2MP0003693_abnormal_embryo_hatching3.83129671
3MP0004264_abnormal_extraembryonic_tissu3.33385135
4MP0002796_impaired_skin_barrier2.78828886
5MP0003941_abnormal_skin_development2.77753602
6MP0002098_abnormal_vibrissa_morphology2.59638230
7MP0004957_abnormal_blastocyst_morpholog2.44254059
8MP0003718_maternal_effect2.32793314
9MP0000462_abnormal_digestive_system2.23602720
10MP0002254_reproductive_system_inflammat2.23564878
11MP0010352_gastrointestinal_tract_polyps2.19065264
12MP0000537_abnormal_urethra_morphology2.14227119
13MP0009780_abnormal_chondrocyte_physiolo2.09627410
14MP0002877_abnormal_melanocyte_morpholog2.05180528
15MP0004043_abnormal_pH_regulation1.97823838
16MP0001666_abnormal_nutrient_absorption1.97424249
17MP0000678_abnormal_parathyroid_gland1.96982161
18MP0000613_abnormal_salivary_gland1.78666905
19MP0009672_abnormal_birth_weight1.78545256
20MP0003878_abnormal_ear_physiology1.78075547
21MP0005377_hearing/vestibular/ear_phenot1.78075547
22MP0000566_synostosis1.75897216
23MP0010678_abnormal_skin_adnexa1.75607840
24MP0005220_abnormal_exocrine_pancreas1.73816646
25MP0005408_hypopigmentation1.73104001
26MP0003300_gastrointestinal_ulcer1.67202287
27MP0005501_abnormal_skin_physiology1.66309948
28MP0003315_abnormal_perineum_morphology1.61242154
29MP0001756_abnormal_urination1.58151973
30MP0003111_abnormal_nucleus_morphology1.57394179
31MP0003705_abnormal_hypodermis_morpholog1.56461539
32MP0002060_abnormal_skin_morphology1.54004408
33MP0008789_abnormal_olfactory_epithelium1.52074744
34MP0002277_abnormal_respiratory_mucosa1.50816937
35MP0001216_abnormal_epidermal_layer1.49689729
36MP0002132_abnormal_respiratory_system1.45369033
37MP0004019_abnormal_vitamin_homeostasis1.43209543
38MP0000490_abnormal_crypts_of1.41368063
39MP0003119_abnormal_digestive_system1.41189015
40MP0001849_ear_inflammation1.39893785
41MP0010386_abnormal_urinary_bladder1.36916092
42MP0008004_abnormal_stomach_pH1.35128730
43MP0000383_abnormal_hair_follicle1.32733089
44MP0004782_abnormal_surfactant_physiolog1.32468989
45MP0003453_abnormal_keratinocyte_physiol1.32073562
46MP0010030_abnormal_orbit_morphology1.30638776
47MP0009643_abnormal_urine_homeostasis1.30508810
48MP0001346_abnormal_lacrimal_gland1.29021184
49MP0003077_abnormal_cell_cycle1.27238736
50MP0001730_embryonic_growth_arrest1.26885644
51MP0003890_abnormal_embryonic-extraembry1.25224234
52MP0000377_abnormal_hair_follicle1.25035059
53MP0000579_abnormal_nail_morphology1.23440654
54MP0001944_abnormal_pancreas_morphology1.23374858
55MP0000762_abnormal_tongue_morphology1.20895102
56MP0005395_other_phenotype1.18244561
57MP0002163_abnormal_gland_morphology1.18214787
58MP0003866_abnormal_defecation1.17986167
59MP0005360_urolithiasis1.17700783
60MP0003186_abnormal_redox_activity1.14256476
61MP0004185_abnormal_adipocyte_glucose1.14162754
62MP0000467_abnormal_esophagus_morphology1.13629359
63MP0002693_abnormal_pancreas_physiology1.13078774
64MP0003123_paternal_imprinting1.12728111
65MP0002234_abnormal_pharynx_morphology1.12325133
66MP0008058_abnormal_DNA_repair1.11645210
67MP0005083_abnormal_biliary_tract1.10581826
68MP0005275_abnormal_skin_tensile1.06259496
69MP0001485_abnormal_pinna_reflex1.06235035
70MP0003283_abnormal_digestive_organ1.05304508
71MP0003786_premature_aging1.05151343
72MP0005379_endocrine/exocrine_gland_phen1.04431890
73MP0001765_abnormal_ion_homeostasis1.01460335
74MP0000477_abnormal_intestine_morphology1.00910432
75MP0003566_abnormal_cell_adhesion1.00831924
76MP0010094_abnormal_chromosome_stability1.00430670
77MP0008932_abnormal_embryonic_tissue1.00297549
78MP0001697_abnormal_embryo_size0.98930340
79MP0002080_prenatal_lethality0.97103332
80MP0002909_abnormal_adrenal_gland0.96086806
81MP0009703_decreased_birth_body0.95645850
82MP0005332_abnormal_amino_acid0.95247191
83MP0005257_abnormal_intraocular_pressure0.95007893
84MP0000627_abnormal_mammary_gland0.94107871
85MP0005365_abnormal_bile_salt0.93976093
86MP0003806_abnormal_nucleotide_metabolis0.93620694
87MP0000647_abnormal_sebaceous_gland0.92915498
88MP0000538_abnormal_urinary_bladder0.92568457
89MP0005367_renal/urinary_system_phenotyp0.92428536
90MP0000516_abnormal_urinary_system0.92428536
91MP0002653_abnormal_ependyma_morphology0.91576459
92MP0002697_abnormal_eye_size0.91499423
93MP0004233_abnormal_muscle_weight0.90801775
94MP0002160_abnormal_reproductive_system0.90746426
95MP0001727_abnormal_embryo_implantation0.90042863
96MP0002086_abnormal_extraembryonic_tissu0.89557870
97MP0000350_abnormal_cell_proliferation0.89485284
98MP0005636_abnormal_mineral_homeostasis0.89211115
99MP0002085_abnormal_embryonic_tissue0.88465362
100MP0010771_integument_phenotype0.88341411
101MP0003984_embryonic_growth_retardation0.88282955
102MP0000470_abnormal_stomach_morphology0.88123721
103MP0002088_abnormal_embryonic_growth/wei0.87721273
104MP0001664_abnormal_digestion0.87134794
105MP0008875_abnormal_xenobiotic_pharmacok0.86478963
106MP0006054_spinal_hemorrhage0.85849684
107MP0001881_abnormal_mammary_gland0.85564823
108MP0002084_abnormal_developmental_patter0.85377670
109MP0005499_abnormal_olfactory_system0.84911377
110MP0005394_taste/olfaction_phenotype0.84911377
111MP0005380_embryogenesis_phenotype0.84576360
112MP0001672_abnormal_embryogenesis/_devel0.84576360
113MP0009379_abnormal_foot_pigmentation0.84265960
114MP0003936_abnormal_reproductive_system0.82262438
115MP0005389_reproductive_system_phenotype0.82100588
116MP0006035_abnormal_mitochondrial_morpho0.81609146
117MP0009053_abnormal_anal_canal0.81211666
118MP0002111_abnormal_tail_morphology0.80611690
119MP0000427_abnormal_hair_cycle0.80354299
120MP0002233_abnormal_nose_morphology0.79872853
121MP0008007_abnormal_cellular_replicative0.79870203
122MP0005076_abnormal_cell_differentiation0.79774050
123MP0002009_preneoplasia0.79669356
124MP0000003_abnormal_adipose_tissue0.79443545
125MP0004133_heterotaxia0.77219779
126MP0003937_abnormal_limbs/digits/tail_de0.75532939
127MP0003638_abnormal_response/metabolism_0.75311792
128MP0003183_abnormal_peptide_metabolism0.71665342
129MP0000358_abnormal_cell_content/0.69900906
130MP0008872_abnormal_physiological_respon0.66797452
131MP0005085_abnormal_gallbladder_physiolo0.65749754
132MP0002736_abnormal_nociception_after0.65535292

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)4.95549409
2Chronic bronchitis (HP:0004469)4.41084223
3Abnormality of chloride homeostasis (HP:0011422)4.36461581
4Right ventricular cardiomyopathy (HP:0011663)4.29939550
5Onycholysis (HP:0001806)3.97982137
6Abnormality of cochlea (HP:0000375)3.86695533
7Pili torti (HP:0003777)3.85511035
8Renal salt wasting (HP:0000127)3.65753500
9Hypokalemic alkalosis (HP:0001949)3.52472496
10Fragile nails (HP:0001808)3.42269736
11Ileus (HP:0002595)3.41034203
12Woolly hair (HP:0002224)3.31452281
13Abnormal biliary tract morphology (HP:0012440)3.19752400
14Hyperaldosteronism (HP:0000859)3.14126049
15Septate vagina (HP:0001153)3.04477917
16Hypoplastic labia majora (HP:0000059)3.02174090
17Lip pit (HP:0100267)2.96328023
18Abnormal pancreas size (HP:0012094)2.92180181
19Trismus (HP:0000211)2.91375731
20Hyperglycemia (HP:0003074)2.90864672
21Decreased circulating renin level (HP:0003351)2.86456946
22Abnormality of the distal phalanges of the toes (HP:0010182)2.84881470
23Male infertility (HP:0003251)2.83964697
24Plantar hyperkeratosis (HP:0007556)2.73283918
25Milia (HP:0001056)2.72665779
26Abnormality of the labia majora (HP:0012881)2.71248894
27Aplasia/hypoplasia of the uterus (HP:0008684)2.66836532
28Rectal prolapse (HP:0002035)2.59555626
29Breast carcinoma (HP:0003002)2.59138450
30Hypoplasia of the uterus (HP:0000013)2.57974944
31Carpal bone hypoplasia (HP:0001498)2.56249516
32Morphological abnormality of the inner ear (HP:0011390)2.55820460
33Breast hypoplasia (HP:0003187)2.55441237
34Stenosis of the external auditory canal (HP:0000402)2.53845664
35Intrahepatic cholestasis (HP:0001406)2.53046626
36Hypokalemia (HP:0002900)2.52308290
3711 pairs of ribs (HP:0000878)2.51713055
38Amelogenesis imperfecta (HP:0000705)2.51010117
39Gout (HP:0001997)2.48935498
40Multiple enchondromatosis (HP:0005701)2.45918498
41Hyponatremia (HP:0002902)2.43580812
42Rough bone trabeculation (HP:0100670)2.41839283
43Biliary tract neoplasm (HP:0100574)2.38880551
44Megaloblastic anemia (HP:0001889)2.38304677
45Popliteal pterygium (HP:0009756)2.37037272
46Abnormality of small intestinal villus morphology (HP:0011472)2.36218787
47Villous atrophy (HP:0011473)2.36218787
48Microretrognathia (HP:0000308)2.33899252
49Curly hair (HP:0002212)2.31790880
50Abnormality of methionine metabolism (HP:0010901)2.31004360
51Abnormality of renin-angiotensin system (HP:0000847)2.30123527
52Selective tooth agenesis (HP:0001592)2.28478559
53Symptomatic seizures (HP:0011145)2.28454702
54Spinal muscular atrophy (HP:0007269)2.27358345
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.25744415
56Insulin-resistant diabetes mellitus (HP:0000831)2.25506823
57Dehydration (HP:0001944)2.24715229
58Hyperphosphatemia (HP:0002905)2.23456553
59Abnormality of serine family amino acid metabolism (HP:0010894)2.22799362
60Abnormality of glycine metabolism (HP:0010895)2.22799362
61Congenital ichthyosiform erythroderma (HP:0007431)2.19119042
62Vascular calcification (HP:0004934)2.16279256
63Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15947769
64Hypokinesia (HP:0002375)2.14878303
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.13777485
66Abnormality of serum amino acid levels (HP:0003112)2.13749552
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12004005
68Facial cleft (HP:0002006)2.11135675
69Abdominal distention (HP:0003270)2.11047168
70Abnormality of the umbilical cord (HP:0010881)2.10417759
71Hypoplasia of dental enamel (HP:0006297)2.09310325
72Metabolic alkalosis (HP:0200114)2.07722541
73Conjugated hyperbilirubinemia (HP:0002908)2.07541823
74Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07071331
75Colon cancer (HP:0003003)2.06726624
76Secondary amenorrhea (HP:0000869)2.05341147
77Nail dystrophy (HP:0008404)2.04670889
78Testicular atrophy (HP:0000029)2.03758857
79Sparse eyelashes (HP:0000653)2.03514594
80Hypoglycemic coma (HP:0001325)2.00765448
81Absent eyebrow (HP:0002223)2.00433415
82Uterine neoplasm (HP:0010784)2.00302947
83Pterygium (HP:0001059)2.00041172
84Hyperparathyroidism (HP:0000843)1.99192129
85Hypotension (HP:0002615)1.99022680
86Abnormality of the salivary glands (HP:0010286)1.98694238
87Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97865295
88Absent eyelashes (HP:0000561)1.97579351
89Ependymoma (HP:0002888)1.96044592
90Exocrine pancreatic insufficiency (HP:0001738)1.95865552
91Osteomalacia (HP:0002749)1.95719816
92Abnormal trabecular bone morphology (HP:0100671)1.95134701
93Proximal tubulopathy (HP:0000114)1.94813386
94Hyperglycinuria (HP:0003108)1.94499704
95Abnormalities of placenta or umbilical cord (HP:0001194)1.94049261
96Abnormality of permanent molar morphology (HP:0011071)1.93652507
97Abnormality of the dental root (HP:0006486)1.93652507
98Taurodontia (HP:0000679)1.93652507
99Flat acetabular roof (HP:0003180)1.93087036
100Malnutrition (HP:0004395)1.91883394
101Congenital, generalized hypertrichosis (HP:0004540)1.90724761
102Abnormal hair laboratory examination (HP:0003328)1.90393693
103Anal stenosis (HP:0002025)1.89439786
104Progressive hearing impairment (HP:0001730)1.89374280
105Hyperinsulinemic hypoglycemia (HP:0000825)1.88549203
106Natal tooth (HP:0000695)1.88218825
107Abnormality of urine glucose concentration (HP:0011016)1.87980025
108Glycosuria (HP:0003076)1.87980025
109Death in infancy (HP:0001522)1.87939677
110Abnormal blistering of the skin (HP:0008066)1.87517590
111Alkalosis (HP:0001948)1.85984108
112Pustule (HP:0200039)1.85960961
113Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.85915939
114Shawl scrotum (HP:0000049)1.85901035
115Abnormality of sodium homeostasis (HP:0010931)1.85621094
116Hypoglycemic seizures (HP:0002173)1.85325922
117Ventricular fibrillation (HP:0001663)1.83321028
118Chromsome breakage (HP:0040012)1.83029672
119Aplasia/hypoplasia of the humerus (HP:0006507)1.82906802
120Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82527233
121Abnormal hemoglobin (HP:0011902)1.82347683
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81977663
123Spastic diplegia (HP:0001264)1.81348508
124Premature ovarian failure (HP:0008209)1.79622345
125Abnormality of potassium homeostasis (HP:0011042)1.78331173
126Micronodular cirrhosis (HP:0001413)1.78313228
127Hyperkalemia (HP:0002153)1.78122323
128Abnormality of the labia minora (HP:0012880)1.77456466
129Abnormality of the preputium (HP:0100587)1.76355809
130Spinal cord compression (HP:0002176)1.76348183
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75489832
132Missing ribs (HP:0000921)1.75237084
133Atrophic scars (HP:0001075)1.74710595
134Oral leukoplakia (HP:0002745)1.74494034
135Hypoplastic female external genitalia (HP:0012815)1.73886096
136Neoplasm of the adrenal gland (HP:0100631)1.73750734
137Abnormality of the gastric mucosa (HP:0004295)1.73414505
138Abnormality of nail color (HP:0100643)1.73341143
139Acute encephalopathy (HP:0006846)1.72872788
140Asymmetry of the thorax (HP:0001555)1.72666913
141Progressive sensorineural hearing impairment (HP:0000408)1.71876330
142Type I transferrin isoform profile (HP:0003642)1.71604488
143Lethargy (HP:0001254)1.71454745
144Absent radius (HP:0003974)1.71350806
145Degeneration of anterior horn cells (HP:0002398)1.71322359
146Abnormality of the anterior horn cell (HP:0006802)1.71322359
147Unilateral renal agenesis (HP:0000122)1.71256073
148Microglossia (HP:0000171)1.70000575
149Abnormality of alanine metabolism (HP:0010916)1.69370468
150Hyperalaninemia (HP:0003348)1.69370468
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69370468
152Choanal stenosis (HP:0000452)1.69095066
153Rhinitis (HP:0012384)1.67917815
154Tongue fasciculations (HP:0001308)1.67907427
155Advanced eruption of teeth (HP:0006288)1.67809538
156Malignant gastrointestinal tract tumors (HP:0006749)1.66739997
157Gastrointestinal carcinoma (HP:0002672)1.66739997
158Birth length less than 3rd percentile (HP:0003561)1.66448495
159Abnormality of molar (HP:0011077)1.65696872
160Abnormality of molar morphology (HP:0011070)1.65696872
161Hyperglycinemia (HP:0002154)1.65613299
162Esophageal varix (HP:0002040)1.64412925
163Hyperammonemia (HP:0001987)1.64169426
164Abnormality of homocysteine metabolism (HP:0010919)1.64165532
165Homocystinuria (HP:0002156)1.64165532
166Fasciculations (HP:0002380)1.63764305
167Palmoplantar hyperkeratosis (HP:0000972)1.63608663
168Abnormality of magnesium homeostasis (HP:0004921)1.63491041
169Distal lower limb muscle weakness (HP:0009053)1.63004250

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.16450046
2LMTK24.25066824
3PBK3.40426207
4STK38L3.10754161
5VRK23.09549716
6BUB13.04745148
7MAP3K22.95553805
8FRK2.91628040
9SMG12.85405389
10MST1R2.74919966
11LATS12.53521879
12MST42.52903438
13MAP3K122.40184235
14MAP3K32.37730353
15RPS6KB22.32606339
16TRIB32.31459628
17NME12.28041842
18MAP2K22.16541714
19TTK2.02266870
20AKT31.93480028
21PASK1.86873279
22MAPK151.82459079
23SIK11.74284192
24WEE11.73896390
25PKN21.67656646
26PLK41.63999981
27MAPKAPK31.59006032
28TRIM281.53039513
29TAF11.52606145
30PRKCI1.51525874
31MET1.50309574
32IRAK31.48267479
33INSRR1.47581457
34SRPK11.44405272
35FER1.39811842
36NUAK11.38346516
37EIF2AK31.29232006
38ILK1.22593937
39TESK11.18840583
40AURKB1.18181079
41MAP3K91.15005288
42BCKDK1.14902919
43WNK41.14304039
44TSSK61.10080240
45BRSK21.08516287
46PRKG21.06285680
47NEK21.05878123
48DYRK31.05273188
49MUSK1.04918187
50CDC71.04868147
51STK101.02286531
52NEK60.99766642
53STK390.98325559
54ERBB30.96315794
55DAPK10.94019077
56ZAK0.93452627
57MAP3K80.93412219
58STK30.92639693
59PTK20.92096028
60PTK60.90612855
61EEF2K0.90381584
62PLK10.90255554
63PDK20.88665956
64STK160.87676076
65AURKA0.87577535
66PLK30.86664141
67TESK20.85805098
68EIF2AK10.85798785
69BRAF0.85524804
70LATS20.84844572
71ERN10.84321356
72FGFR40.83114073
73WNK30.81457737
74MYLK0.79111340
75NLK0.78501711
76EPHB20.75928663
77NEK10.74205689
78OXSR10.70662778
79BMX0.70029855
80STK240.69284223
81PAK40.69117877
82NME20.68393822
83RPS6KA40.67375816
84MAP2K10.67230784
85CHEK20.65579318
86ACVR1B0.64615707
87MELK0.64019989
88LRRK20.63726526
89STK40.63427264
90BMPR20.63112541
91HIPK20.62882424
92KSR20.62154505
93TAOK10.59976187
94EPHA30.58334487
95SCYL20.56703980
96ALK0.56581151
97VRK10.52648949
98TNIK0.52405737
99CAMK2G0.51481459
100ARAF0.48975885
101CDK90.48315803
102TAOK30.47099104
103CDK70.45909214
104EIF2AK20.43594480
105PDK40.43116924
106PDK30.43116924
107BRSK10.41198086
108AKT20.40681113
109MKNK20.40322334
110CAMK2D0.40266025
111CSNK1E0.40144419
112BCR0.39634654
113DYRK1B0.39514413
114IRAK10.39512938
115PIK3CG0.38742031
116FGFR10.38432370
117MAP3K100.38128640
118TLK10.38005897
119PAK10.37453545
120GRK10.37092924
121BMPR1B0.36720404
122MAP3K110.35538907
123FGFR20.35334785
124CDK60.33922163
125MAP3K10.33768668
126SIK30.33436102
127RIPK10.32552538
128DAPK30.32115966
129MTOR0.29699910
130CHEK10.28864880
131MAP2K60.28193792
132PIK3CA0.28057380
133ATR0.27686103
134MAPKAPK20.27662636
135CSNK2A10.25512450
136CHUK0.25223912
137ERBB20.24216842
138ERBB40.23751498
139RPS6KA10.22332296
140ATM0.21398214

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.48746734
2Protein export_Homo sapiens_hsa030603.02228604
3RNA polymerase_Homo sapiens_hsa030202.90904340
4Proteasome_Homo sapiens_hsa030502.65266784
5Folate biosynthesis_Homo sapiens_hsa007902.64977887
6Ribosome_Homo sapiens_hsa030102.49075857
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.40024862
8Sulfur metabolism_Homo sapiens_hsa009202.37530323
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32480741
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11113455
11Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02399867
12RNA transport_Homo sapiens_hsa030132.02347592
13Mineral absorption_Homo sapiens_hsa049782.00723993
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88033415
15Pyrimidine metabolism_Homo sapiens_hsa002401.86630908
16Biosynthesis of amino acids_Homo sapiens_hsa012301.77935856
17Fat digestion and absorption_Homo sapiens_hsa049751.76544930
18Selenocompound metabolism_Homo sapiens_hsa004501.74613966
19Fatty acid elongation_Homo sapiens_hsa000621.70675201
20Arginine biosynthesis_Homo sapiens_hsa002201.53465204
21Glutathione metabolism_Homo sapiens_hsa004801.52762119
22Linoleic acid metabolism_Homo sapiens_hsa005911.51547812
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49235255
24Pyruvate metabolism_Homo sapiens_hsa006201.47970033
25Carbon metabolism_Homo sapiens_hsa012001.45266462
26Vibrio cholerae infection_Homo sapiens_hsa051101.44262028
27Steroid biosynthesis_Homo sapiens_hsa001001.43434156
28Tight junction_Homo sapiens_hsa045301.42457325
29Other glycan degradation_Homo sapiens_hsa005111.39885980
30DNA replication_Homo sapiens_hsa030301.37956853
31Arachidonic acid metabolism_Homo sapiens_hsa005901.36850081
32Regulation of autophagy_Homo sapiens_hsa041401.36752198
33Spliceosome_Homo sapiens_hsa030401.36492342
34Mismatch repair_Homo sapiens_hsa034301.35681677
35Cell cycle_Homo sapiens_hsa041101.34591068
36Homologous recombination_Homo sapiens_hsa034401.32503179
37Sphingolipid metabolism_Homo sapiens_hsa006001.30631437
38Basal transcription factors_Homo sapiens_hsa030221.29498606
39Vitamin digestion and absorption_Homo sapiens_hsa049771.29223748
40Galactose metabolism_Homo sapiens_hsa000521.23523780
41Fructose and mannose metabolism_Homo sapiens_hsa000511.21858956
42p53 signaling pathway_Homo sapiens_hsa041151.19092533
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17702925
44RNA degradation_Homo sapiens_hsa030181.15777423
45Thyroid cancer_Homo sapiens_hsa052161.15072430
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08283028
47Oxidative phosphorylation_Homo sapiens_hsa001901.06675343
48Base excision repair_Homo sapiens_hsa034101.05979190
49Nucleotide excision repair_Homo sapiens_hsa034201.03266403
50Hippo signaling pathway_Homo sapiens_hsa043901.02433982
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.02264090
52Pancreatic secretion_Homo sapiens_hsa049721.01519165
53Purine metabolism_Homo sapiens_hsa002301.00846148
54Renin-angiotensin system_Homo sapiens_hsa046141.00733177
55Protein digestion and absorption_Homo sapiens_hsa049740.99444016
56Bladder cancer_Homo sapiens_hsa052190.98533072
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.97858509
58Vitamin B6 metabolism_Homo sapiens_hsa007500.96877088
59Propanoate metabolism_Homo sapiens_hsa006400.95399622
60Adherens junction_Homo sapiens_hsa045200.95123503
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94286466
62Histidine metabolism_Homo sapiens_hsa003400.94108523
63Starch and sucrose metabolism_Homo sapiens_hsa005000.93470281
64Tyrosine metabolism_Homo sapiens_hsa003500.92595546
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92183072
66One carbon pool by folate_Homo sapiens_hsa006700.90710860
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90703328
68N-Glycan biosynthesis_Homo sapiens_hsa005100.88998554
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86436966
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85096369
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84958098
72Caffeine metabolism_Homo sapiens_hsa002320.83197215
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82769577
74Glycerolipid metabolism_Homo sapiens_hsa005610.82503107
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82502893
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81160073
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80029923
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77809360
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.76201960
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75845517
81Sulfur relay system_Homo sapiens_hsa041220.74282623
82mRNA surveillance pathway_Homo sapiens_hsa030150.72815447
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72509605
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.72039508
85Fatty acid metabolism_Homo sapiens_hsa012120.69386333
86Parkinsons disease_Homo sapiens_hsa050120.68283889
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.64504704
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64421853
89Pentose phosphate pathway_Homo sapiens_hsa000300.63655914
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.60627705
91Peroxisome_Homo sapiens_hsa041460.59559280
92Arginine and proline metabolism_Homo sapiens_hsa003300.58459712
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56067244
94Circadian rhythm_Homo sapiens_hsa047100.55610648
95Tryptophan metabolism_Homo sapiens_hsa003800.54769436
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54380358
97Fanconi anemia pathway_Homo sapiens_hsa034600.53895355
98Metabolic pathways_Homo sapiens_hsa011000.53365866
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52555190
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52188103
101Epstein-Barr virus infection_Homo sapiens_hsa051690.51437722
102Fatty acid degradation_Homo sapiens_hsa000710.50491330
103Chemical carcinogenesis_Homo sapiens_hsa052040.50294754
104TGF-beta signaling pathway_Homo sapiens_hsa043500.50238887
105Ether lipid metabolism_Homo sapiens_hsa005650.49595972
106Basal cell carcinoma_Homo sapiens_hsa052170.46974554
107Non-homologous end-joining_Homo sapiens_hsa034500.45721075
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43791067
109Endometrial cancer_Homo sapiens_hsa052130.43554349
110Hepatitis C_Homo sapiens_hsa051600.43333950
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42615887
112Small cell lung cancer_Homo sapiens_hsa052220.41400717
113Retinol metabolism_Homo sapiens_hsa008300.41160902
114Phenylalanine metabolism_Homo sapiens_hsa003600.40909932
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40820782
116Alzheimers disease_Homo sapiens_hsa050100.40772498
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40490618
118Antigen processing and presentation_Homo sapiens_hsa046120.39584400
119beta-Alanine metabolism_Homo sapiens_hsa004100.38861554
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37987696
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37973943
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37283887
123Prostate cancer_Homo sapiens_hsa052150.37078059
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36132210
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35732321
126Fatty acid biosynthesis_Homo sapiens_hsa000610.35346791
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.34848068
128Collecting duct acid secretion_Homo sapiens_hsa049660.31693090
129Thyroid hormone synthesis_Homo sapiens_hsa049180.30987590
130Huntingtons disease_Homo sapiens_hsa050160.29177465

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