AP1S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.41338934
2COPI coating of Golgi vesicle (GO:0048205)6.41338934
3synaptic vesicle maturation (GO:0016188)6.31433846
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.97879756
5synaptic vesicle exocytosis (GO:0016079)5.73806947
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.54709322
7locomotory exploration behavior (GO:0035641)5.21017787
8protein retention in ER lumen (GO:0006621)5.19784184
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15306395
10regulation of synapse structural plasticity (GO:0051823)5.13611393
11glutamate secretion (GO:0014047)5.04274067
12vocalization behavior (GO:0071625)5.02299949
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98176022
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.97996499
15regulation of synaptic vesicle exocytosis (GO:2000300)4.93176763
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.74805755
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.73394514
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.72655986
19regulation of neuronal synaptic plasticity (GO:0048168)4.63748547
20regulation of glutamate receptor signaling pathway (GO:1900449)4.53946454
21protein localization to endosome (GO:0036010)4.50760276
22protein localization to synapse (GO:0035418)4.40514200
23regulation of synaptic vesicle transport (GO:1902803)4.38974030
24negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.38748370
25protein maturation by protein folding (GO:0022417)4.25698582
26neurotransmitter secretion (GO:0007269)4.19623251
27proline biosynthetic process (GO:0006561)4.17166967
28neuronal action potential propagation (GO:0019227)4.15990662
29exploration behavior (GO:0035640)4.13001211
30negative regulation of microtubule polymerization (GO:0031115)4.05775605
31regulation of mammary gland epithelial cell proliferation (GO:0033599)4.05355921
32positive regulation of synapse maturation (GO:0090129)3.89154563
33adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.84952723
34positive regulation of neurotransmitter transport (GO:0051590)3.80296910
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.78665984
36layer formation in cerebral cortex (GO:0021819)3.78201251
37G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.75906805
38synaptic transmission, dopaminergic (GO:0001963)3.75396664
39regulation of synaptic plasticity (GO:0048167)3.70705804
40positive regulation of synaptic transmission, GABAergic (GO:0032230)3.70473572
41positive regulation of neurotransmitter secretion (GO:0001956)3.69490088
42positive regulation of membrane potential (GO:0045838)3.67078121
43dopamine receptor signaling pathway (GO:0007212)3.66732806
44activation of protein kinase A activity (GO:0034199)3.65583744
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.65130937
46neuromuscular process controlling balance (GO:0050885)3.61776790
47neurotransmitter-gated ion channel clustering (GO:0072578)3.60975811
48prepulse inhibition (GO:0060134)3.58148334
49synaptic transmission, glutamatergic (GO:0035249)3.57235895
50dendritic spine morphogenesis (GO:0060997)3.55951795
51cytoskeletal anchoring at plasma membrane (GO:0007016)3.51672025
52neuron-neuron synaptic transmission (GO:0007270)3.50680616
53hemidesmosome assembly (GO:0031581)3.50086670
54regulation of glutamate secretion (GO:0014048)3.49218143
55proline transport (GO:0015824)3.49088034
56negative regulation of cell size (GO:0045792)3.47281592
57regulation of early endosome to late endosome transport (GO:2000641)3.46841637
58adherens junction assembly (GO:0034333)3.46120610
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44247245
60cerebellar Purkinje cell layer development (GO:0021680)3.42851720
61positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.42547728
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41710912
63skin morphogenesis (GO:0043589)3.41615999
64activation of Rac GTPase activity (GO:0032863)3.41295083
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38784090
66focal adhesion assembly (GO:0048041)3.34828964
67cell-substrate adherens junction assembly (GO:0007045)3.34828964
68regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.34647050
69regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.34647050
70pentose-phosphate shunt (GO:0006098)3.33143532
71glucose 6-phosphate metabolic process (GO:0051156)3.32151264
72regulation of dendritic spine morphogenesis (GO:0061001)3.31912624
73barbed-end actin filament capping (GO:0051016)3.30149584
74neuron cell-cell adhesion (GO:0007158)3.26218796
75neuromuscular process controlling posture (GO:0050884)3.24614190
76cell-substrate junction assembly (GO:0007044)3.23699076
77nucleobase-containing small molecule interconversion (GO:0015949)3.22878983
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21587702
79auditory behavior (GO:0031223)3.21460141
80long-term synaptic potentiation (GO:0060291)3.20464249
81transferrin transport (GO:0033572)3.20197273
82mitotic nuclear envelope reassembly (GO:0007084)3.20113956
83nuclear envelope reassembly (GO:0031468)3.20113956
84regulation of vesicle fusion (GO:0031338)3.19827636
85positive regulation of vesicle fusion (GO:0031340)3.17437501
86long-term memory (GO:0007616)3.17138389
87semaphorin-plexin signaling pathway (GO:0071526)3.17110776
88regulation of translational fidelity (GO:0006450)3.15618260
89desmosome organization (GO:0002934)3.15402239
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.15237627
91ATP hydrolysis coupled proton transport (GO:0015991)3.15237627
92neurotransmitter transport (GO:0006836)3.14436371
93regulation of female receptivity (GO:0045924)3.14197301
94dendritic spine organization (GO:0097061)3.13233718
95regulation of postsynaptic membrane potential (GO:0060078)3.13200024
96positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.12915006
97regulation of neurotransmitter secretion (GO:0046928)3.09937875
98regulation of neurotransmitter levels (GO:0001505)3.07148887
99vesicle coating (GO:0006901)3.07100548
100maternal placenta development (GO:0001893)3.06766135
101negative regulation of dendrite morphogenesis (GO:0050774)3.05973832
102basement membrane organization (GO:0071711)3.05620972
103glutamate receptor signaling pathway (GO:0007215)3.04688472
104glucose catabolic process (GO:0006007)3.04138851
105endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.04061172
106regulation of neurotransmitter transport (GO:0051588)3.03424419
107cell adhesion mediated by integrin (GO:0033627)3.03383428
108response to auditory stimulus (GO:0010996)3.03338375
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03092431
110response to amphetamine (GO:0001975)3.02722926
111peptidyl-arginine omega-N-methylation (GO:0035247)3.02215347
112striatum development (GO:0021756)3.00443245
113positive regulation of fibroblast migration (GO:0010763)2.99370643
114vesicle transport along microtubule (GO:0047496)2.96354017
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95558592
116behavioral defense response (GO:0002209)2.95356101
117behavioral fear response (GO:0001662)2.95356101
118positive regulation of synaptic transmission (GO:0050806)2.94709992
119epithelial cell-cell adhesion (GO:0090136)2.94287446
120regulation of synaptic transmission, glutamatergic (GO:0051966)2.94189741
121negative regulation of dendrite development (GO:2000171)2.94164442
122neuronal ion channel clustering (GO:0045161)2.92836192
123negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91976825
124regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.91839133
125trivalent inorganic cation transport (GO:0072512)2.91333302
126ferric iron transport (GO:0015682)2.91333302
127regulation of synaptic transmission, dopaminergic (GO:0032225)2.90594220
128stress fiber assembly (GO:0043149)2.89610918
129regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.89587143
130behavioral response to cocaine (GO:0048148)2.89326047
131NADPH regeneration (GO:0006740)2.89009885
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87946707
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87762685
134glycine transport (GO:0015816)2.86306096
135positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.85837099
136regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.85837099
137gamma-aminobutyric acid transport (GO:0015812)2.85766301
138response to histamine (GO:0034776)2.84679965
139positive regulation of nuclease activity (GO:0032075)2.84351648
140sodium ion export (GO:0071436)2.84312537
141proline metabolic process (GO:0006560)2.83692478
142neuromuscular process (GO:0050905)2.82602014
143regulation of synaptic transmission (GO:0050804)2.82473201
144regulation of neurotransmitter uptake (GO:0051580)2.81674520
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81413355
146negative regulation of amino acid transport (GO:0051956)2.79812167
147female mating behavior (GO:0060180)2.79120007
148peptidyl-proline hydroxylation (GO:0019511)2.78776982
149adenosine receptor signaling pathway (GO:0001973)2.78023215
150synaptic vesicle endocytosis (GO:0048488)2.77450938
151establishment of synaptic vesicle localization (GO:0097480)2.75975704
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.74656393
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69364664
154positive regulation of Cdc42 GTPase activity (GO:0043089)2.68475094
155endoplasmic reticulum unfolded protein response (GO:0030968)2.68100869
156GDP-mannose metabolic process (GO:0019673)2.67572000
157branching involved in mammary gland duct morphogenesis (GO:0060444)2.66776416
158apoptotic process involved in morphogenesis (GO:0060561)2.62709115
159endothelial cell chemotaxis (GO:0035767)2.60087590
160actin filament bundle organization (GO:0061572)2.59877443
161actin filament bundle assembly (GO:0051017)2.59877443
162protein hydroxylation (GO:0018126)2.58576111
163DNA unwinding involved in DNA replication (GO:0006268)2.58049883
164NADH metabolic process (GO:0006734)2.57203903
165mitochondrial fusion (GO:0008053)2.56878014
166ER-nucleus signaling pathway (GO:0006984)2.55604331
167positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54589641
168adenine nucleotide transport (GO:0051503)2.53315676
169vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.51830623
1704-hydroxyproline metabolic process (GO:0019471)2.50633045
171glutamine family amino acid biosynthetic process (GO:0009084)2.48919603
172regulation of cholesterol biosynthetic process (GO:0045540)2.48679512
173protein complex localization (GO:0031503)2.47741035
174regulation of nuclease activity (GO:0032069)2.47733741
175spliceosomal tri-snRNP complex assembly (GO:0000244)2.47280987
176cellular copper ion homeostasis (GO:0006878)2.46327793
177cellular response to unfolded protein (GO:0034620)2.46123916
178mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.43692841
179histone arginine methylation (GO:0034969)2.41569593
180positive regulation of keratinocyte differentiation (GO:0045618)2.40988731
181negative regulation of fatty acid transport (GO:2000192)2.40526790
182negative regulation of adherens junction organization (GO:1903392)2.39626191
183negative regulation of focal adhesion assembly (GO:0051895)2.39626191
184negative regulation of cell junction assembly (GO:1901889)2.39626191
185cell-cell junction maintenance (GO:0045217)2.37985443
186protein targeting to plasma membrane (GO:0072661)2.37927638
187peptidyl-arginine methylation (GO:0018216)2.37580304
188peptidyl-arginine N-methylation (GO:0035246)2.37580304
189vagina development (GO:0060068)2.36861039
190negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.36233299
191negative regulation of catenin import into nucleus (GO:0035414)2.34556919
192embryo implantation (GO:0007566)2.33951244
193cellular protein complex localization (GO:0034629)2.32419555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38871329
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.28572895
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.72879388
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.56152311
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.94889527
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.81767355
7REST_21632747_ChIP-Seq_MESCs_Mouse2.76536744
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73313700
9* REST_18959480_ChIP-ChIP_MESCs_Mouse2.72357417
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.63216477
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60772048
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60001448
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59245705
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.58082814
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.57882282
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44120913
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39817456
18* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38722089
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38333771
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38333771
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36462818
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.32521836
23* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.29906096
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25641149
25DNAJC2_21179169_ChIP-ChIP_NT2_Human2.19201401
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18551940
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16865442
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09347399
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06846138
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.04507393
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04032313
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03221226
33SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01723249
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99816132
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99523941
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.97093082
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.95764354
38* LXR_22292898_ChIP-Seq_THP-1_Human1.94578111
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94542339
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88297605
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.80980317
42DROSHA_22980978_ChIP-Seq_HELA_Human1.76477733
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.75986770
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75794583
45CLOCK_20551151_ChIP-Seq_293T_Human1.72708919
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.72069261
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71817740
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.68111280
49VDR_21846776_ChIP-Seq_THP-1_Human1.66295987
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64488074
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61965712
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61847573
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61481453
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61466096
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61112092
56MYC_22102868_ChIP-Seq_BL_Human1.60534066
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60265206
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60140116
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58213709
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.57107881
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56412870
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55183606
63POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54751726
64ATF3_27146783_Chip-Seq_COLON_Human1.52044604
65TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.49892992
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47600381
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47127898
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.46238924
69HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44357864
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.44169817
71* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43040168
72MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42926767
73KDM2B_26808549_Chip-Seq_K562_Human1.41815620
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41184214
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39296710
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.39038387
77MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38020676
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.37545212
79FOXM1_23109430_ChIP-Seq_U2OS_Human1.35859821
80TP53_22127205_ChIP-Seq_IMR90_Human1.35773838
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35453857
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.33015670
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.32746432
84* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31961194
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.31938099
86SMC4_20622854_ChIP-Seq_HELA_Human1.30905881
87CTCF_27219007_Chip-Seq_Bcells_Human1.30666558
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30027889
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27190895
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26165693
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25622878
92CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24477929
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23951470
94ZNF263_19887448_ChIP-Seq_K562_Human1.22939844
95E2F7_22180533_ChIP-Seq_HELA_Human1.22881924
96TCF7_22412390_ChIP-Seq_EML_Mouse1.22522572
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21441870
98KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21083876
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19586837
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18127708
101P68_20966046_ChIP-Seq_HELA_Human1.18116364
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17510703
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15097250
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.14940825
105* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14859962
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14776575
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.13606543
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.13468819
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13264154
110* BCL6_27268052_Chip-Seq_Bcells_Human1.13231927
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13076373
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12740008
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11215399
114CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10547624
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09925109
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.09897886
117* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09050242
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08476366
119FOXP1_21924763_ChIP-Seq_HESCs_Human1.07102701
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07080815
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.05628593
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05605897
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05342772
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05286872
125* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05095431
126AR_21909140_ChIP-Seq_LNCAP_Human1.05077761
127UBF1/2_26484160_Chip-Seq_HMECs_Human1.04343004
128YY1_22570637_ChIP-Seq_MALME-3M_Human1.04283269
129NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03714414
130* RACK7_27058665_Chip-Seq_MCF-7_Human1.02370459
131* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01761000
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01303026
133CREB1_26743006_Chip-Seq_LNCaP_Human1.01035476
134RUNX1_27514584_Chip-Seq_MCF-7_Human1.00605425
135SA1_27219007_Chip-Seq_Bcells_Human1.00081363
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.99224508
137TRIM28_21343339_ChIP-Seq_HEK293_Human0.99192325
138TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96725554
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96000135
140SMAD4_21741376_ChIP-Seq_ESCs_Human0.95915508
141TP53_20018659_ChIP-ChIP_R1E_Mouse0.95910738
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95748408
143PHF8_20622854_ChIP-Seq_HELA_Human0.94597762
144YY1_21170310_ChIP-Seq_MESCs_Mouse0.92783081
145XRN2_22483619_ChIP-Seq_HELA_Human0.92729060
146OCT4_19829295_ChIP-Seq_ESCs_Human0.92532964
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92426812
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92258990
149* BCOR_27268052_Chip-Seq_Bcells_Human0.91204247
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90760090
151RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90366652
152TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89362364
153* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89182671
154KDM2B_26808549_Chip-Seq_DND41_Human0.87813065
155CTCF_20526341_ChIP-Seq_ESCs_Human0.87610819
156NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87321752
157CREB1_15753290_ChIP-ChIP_HEK293T_Human0.86918355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.23086640
2MP0002822_catalepsy5.28519538
3MP0003880_abnormal_central_pattern4.29409524
4MP0003635_abnormal_synaptic_transmissio4.20105021
5MP0008438_abnormal_cutaneous_collagen3.90126164
6MP0002063_abnormal_learning/memory/cond3.45650030
7MP0004270_analgesia3.42998895
8MP0002877_abnormal_melanocyte_morpholog3.33775074
9MP0009745_abnormal_behavioral_response3.31485049
10MP0001968_abnormal_touch/_nociception3.16770546
11MP0002064_seizures3.12869383
12MP0005257_abnormal_intraocular_pressure3.04887744
13MP0002736_abnormal_nociception_after2.76289355
14MP0003566_abnormal_cell_adhesion2.74161133
15MP0004858_abnormal_nervous_system2.70559941
16MP0002572_abnormal_emotion/affect_behav2.66852107
17MP0000537_abnormal_urethra_morphology2.65864295
18MP0009046_muscle_twitch2.62748399
19MP0002734_abnormal_mechanical_nocicepti2.45886258
20MP0005451_abnormal_body_composition2.44771775
21MP0003329_amyloid_beta_deposits2.35632250
22MP0004272_abnormal_basement_membrane2.35261753
23MP0001529_abnormal_vocalization2.31318646
24MP0001849_ear_inflammation2.30625644
25MP0002272_abnormal_nervous_system2.25357874
26MP0002733_abnormal_thermal_nociception2.21447176
27MP0002909_abnormal_adrenal_gland2.19951596
28MP0001970_abnormal_pain_threshold2.17491038
29MP0004811_abnormal_neuron_physiology2.09503249
30MP0009840_abnormal_foam_cell2.09340497
31MP0005423_abnormal_somatic_nervous2.08839736
32MP0002796_impaired_skin_barrier2.08024216
33MP0000013_abnormal_adipose_tissue1.99845256
34MP0002735_abnormal_chemical_nociception1.99284357
35MP0003879_abnormal_hair_cell1.94713051
36MP0001486_abnormal_startle_reflex1.92133829
37MP0001440_abnormal_grooming_behavior1.91921345
38MP0001501_abnormal_sleep_pattern1.91588097
39MP0009053_abnormal_anal_canal1.89342663
40MP0005501_abnormal_skin_physiology1.89107006
41MP0009780_abnormal_chondrocyte_physiolo1.88797383
42MP0010030_abnormal_orbit_morphology1.82804800
43MP0002060_abnormal_skin_morphology1.73159934
44MP0005409_darkened_coat_color1.70979212
45MP0004185_abnormal_adipocyte_glucose1.69901196
46MP0005386_behavior/neurological_phenoty1.63097784
47MP0004924_abnormal_behavior1.63097784
48MP0005076_abnormal_cell_differentiation1.62622289
49MP0002184_abnormal_innervation1.60964193
50MP0008569_lethality_at_weaning1.59603767
51MP0000579_abnormal_nail_morphology1.59368840
52MP0003453_abnormal_keratinocyte_physiol1.56375424
53MP0002557_abnormal_social/conspecific_i1.49116293
54MP0003191_abnormal_cellular_cholesterol1.48620600
55MP0003091_abnormal_cell_migration1.46595673
56MP0002067_abnormal_sensory_capabilities1.46037488
57MP0001905_abnormal_dopamine_level1.42981831
58MP0003075_altered_response_to1.42398697
59MP0000955_abnormal_spinal_cord1.39300393
60MP0000467_abnormal_esophagus_morphology1.36627466
61MP0002066_abnormal_motor_capabilities/c1.35237914
62MP0001984_abnormal_olfaction1.34144371
63MP0000762_abnormal_tongue_morphology1.32472895
64MP0004264_abnormal_extraembryonic_tissu1.31241722
65MP0003941_abnormal_skin_development1.29256812
66MP0000678_abnormal_parathyroid_gland1.25979810
67MP0006276_abnormal_autonomic_nervous1.25192041
68MP0002896_abnormal_bone_mineralization1.22509003
69MP0000604_amyloidosis1.22370600
70MP0002882_abnormal_neuron_morphology1.22070003
71MP0000858_altered_metastatic_potential1.16981096
72MP0000462_abnormal_digestive_system1.16853333
73MP0010352_gastrointestinal_tract_polyps1.15718875
74MP0003942_abnormal_urinary_system1.14509823
75MP0003122_maternal_imprinting1.14466968
76MP0002098_abnormal_vibrissa_morphology1.13821784
77MP0005646_abnormal_pituitary_gland1.13237603
78MP0000733_abnormal_muscle_development1.12458911
79MP0005023_abnormal_wound_healing1.11915733
80MP0000750_abnormal_muscle_regeneration1.11006189
81MP0001216_abnormal_epidermal_layer1.10846993
82MP0008872_abnormal_physiological_respon1.10322657
83MP0010771_integument_phenotype1.07274017
84MP0001730_embryonic_growth_arrest1.07145452
85MP0003172_abnormal_lysosome_physiology1.06828317
86MP0000778_abnormal_nervous_system1.06295522
87MP0004885_abnormal_endolymph1.06263818
88MP0004142_abnormal_muscle_tone1.05179633
89MP0003633_abnormal_nervous_system1.05016797
90MP0005623_abnormal_meninges_morphology1.04979310
91MP0009379_abnormal_foot_pigmentation0.99652520
92MP0003385_abnormal_body_wall0.97263580
93MP0000377_abnormal_hair_follicle0.95111307
94MP0002152_abnormal_brain_morphology0.93977041
95MP0002249_abnormal_larynx_morphology0.93769495
96MP0000751_myopathy0.93608710
97MP0003283_abnormal_digestive_organ0.93428346
98MP0003123_paternal_imprinting0.92829234
99MP0002069_abnormal_eating/drinking_beha0.91989374
100MP0009384_cardiac_valve_regurgitation0.91383691
101MP0004957_abnormal_blastocyst_morpholog0.91322181
102MP0003315_abnormal_perineum_morphology0.90734268
103MP0010386_abnormal_urinary_bladder0.90613617
104MP0008874_decreased_physiological_sensi0.88676383
105MP0005621_abnormal_cell_physiology0.87273008
106MP0002080_prenatal_lethality0.87230592
107MP0003631_nervous_system_phenotype0.86911112
108MP0008932_abnormal_embryonic_tissue0.86890454
109MP0003634_abnormal_glial_cell0.86146092
110MP0003279_aneurysm0.85816254
111MP0009672_abnormal_birth_weight0.85751681
112MP0003183_abnormal_peptide_metabolism0.85500793
113MP0005394_taste/olfaction_phenotype0.84672425
114MP0005499_abnormal_olfactory_system0.84672425
115MP0005275_abnormal_skin_tensile0.82012540
116MP0001243_abnormal_dermal_layer0.81638581
117MP0000627_abnormal_mammary_gland0.80944225
118MP0000350_abnormal_cell_proliferation0.80722754
119MP0005645_abnormal_hypothalamus_physiol0.80563931
120MP0005375_adipose_tissue_phenotype0.80519190
121MP0001727_abnormal_embryo_implantation0.79209057
122MP0005508_abnormal_skeleton_morphology0.79192042
123MP0005197_abnormal_uvea_morphology0.78549579
124MP0005058_abnormal_lysosome_morphology0.76142771
125MP0003111_abnormal_nucleus_morphology0.76002978
126MP0001664_abnormal_digestion0.74692390
127MP0004782_abnormal_surfactant_physiolog0.74185191
128MP0001177_atelectasis0.73941714
129MP0005384_cellular_phenotype0.73672825
130MP0001502_abnormal_circadian_rhythm0.73567617
131MP0003115_abnormal_respiratory_system0.72802149
132MP0002090_abnormal_vision0.72456410
133MP0000358_abnormal_cell_content/0.71360748
134MP0002751_abnormal_autonomic_nervous0.71119593
135MP0010234_abnormal_vibrissa_follicle0.70859500
136MP0001188_hyperpigmentation0.70510523
137MP0004233_abnormal_muscle_weight0.70382179
138MP0005666_abnormal_adipose_tissue0.69884440
139MP0000759_abnormal_skeletal_muscle0.69312734
140MP0002089_abnormal_postnatal_growth/wei0.68571429
141MP0005167_abnormal_blood-brain_barrier0.67980163
142MP0009931_abnormal_skin_appearance0.67673831
143MP0001340_abnormal_eyelid_morphology0.64845606
144MP0002086_abnormal_extraembryonic_tissu0.64618754
145MP0002229_neurodegeneration0.64409771
146MP0006035_abnormal_mitochondrial_morpho0.63561410
147MP0001915_intracranial_hemorrhage0.63053305
148MP0005193_abnormal_anterior_eye0.62925590
149MP0005408_hypopigmentation0.62391318
150MP0002085_abnormal_embryonic_tissue0.61985767
151MP0008260_abnormal_autophagy0.61303859
152MP0008961_abnormal_basal_metabolism0.61226714
153MP0002653_abnormal_ependyma_morphology0.58055891
154MP0003303_peritoneal_inflammation0.57677082
155MP0000747_muscle_weakness0.57163659
156MP0001299_abnormal_eye_distance/0.56737283
157MP0005166_decreased_susceptibility_to0.54288073
158MP0005535_abnormal_body_temperature0.54182875
159MP0001958_emphysema0.53685661
160MP0000534_abnormal_ureter_morphology0.52788833
161MP0003956_abnormal_body_size0.49754653
162MP0004085_abnormal_heartbeat0.49472509
163MP0000003_abnormal_adipose_tissue0.49187972
164MP0005084_abnormal_gallbladder_morpholo0.48053478
165MP0003632_abnormal_nervous_system0.47341892
166MP0001348_abnormal_lacrimal_gland0.47087131
167MP0000681_abnormal_thyroid_gland0.46641788
168MP0001542_abnormal_bone_strength0.46557133
169MP0001943_abnormal_respiration0.45303373
170MP0003705_abnormal_hypodermis_morpholog0.43950914
171MP0010769_abnormal_survival0.41804816

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.10678983
2Focal motor seizures (HP:0011153)5.87013687
3Visual hallucinations (HP:0002367)4.82660746
4Premature rupture of membranes (HP:0001788)4.61532691
5Focal seizures (HP:0007359)4.55541704
6Hyperacusis (HP:0010780)4.16045392
7Ankle clonus (HP:0011448)3.79136177
8Vertebral compression fractures (HP:0002953)3.62098325
9Atonic seizures (HP:0010819)3.61232887
10Absence seizures (HP:0002121)3.34652976
11Annular pancreas (HP:0001734)3.33259068
12Epileptic encephalopathy (HP:0200134)3.28945734
13Torticollis (HP:0000473)3.27261271
14Supranuclear gaze palsy (HP:0000605)3.24467697
15Focal dystonia (HP:0004373)3.22229963
16Pheochromocytoma (HP:0002666)3.20771168
17Delusions (HP:0000746)3.19720568
18Mutism (HP:0002300)3.18951626
19Depression (HP:0000716)3.15836555
20Abnormal eating behavior (HP:0100738)3.06534597
21Generalized tonic-clonic seizures (HP:0002069)3.03821019
22Neuroendocrine neoplasm (HP:0100634)3.03074780
23Papilledema (HP:0001085)3.02050209
24Abnormality of the lower motor neuron (HP:0002366)2.99435315
25Dialeptic seizures (HP:0011146)2.98477296
26Craniofacial dystonia (HP:0012179)2.97741938
27Poor eye contact (HP:0000817)2.96384181
28Anxiety (HP:0000739)2.94367009
29Neoplasm of the peripheral nervous system (HP:0100007)2.75116863
30J-shaped sella turcica (HP:0002680)2.73533510
31Short nail (HP:0001799)2.72112808
32Resting tremor (HP:0002322)2.71554489
33Asymmetry of the thorax (HP:0001555)2.70283963
34Amblyopia (HP:0000646)2.67980649
35Limb dystonia (HP:0002451)2.67019129
36Distal lower limb muscle weakness (HP:0009053)2.64631950
37Ventricular fibrillation (HP:0001663)2.59992602
38Impaired vibration sensation in the lower limbs (HP:0002166)2.59389651
39Pointed chin (HP:0000307)2.59011007
40Atrophic scars (HP:0001075)2.58881755
41Bladder diverticulum (HP:0000015)2.56124306
42Cervical subluxation (HP:0003308)2.55340654
43Overriding aorta (HP:0002623)2.53707197
44Abnormal social behavior (HP:0012433)2.53533603
45Impaired social interactions (HP:0000735)2.53533603
46Upper limb amyotrophy (HP:0009129)2.53011568
47Distal upper limb amyotrophy (HP:0007149)2.53011568
48Ankle contracture (HP:0006466)2.53001500
49Fragile skin (HP:0001030)2.51960957
50Distal lower limb amyotrophy (HP:0008944)2.51425975
51Urinary urgency (HP:0000012)2.49882460
52Apathy (HP:0000741)2.49368837
53Ulnar bowing (HP:0003031)2.49191704
54Action tremor (HP:0002345)2.44907985
55Cerebral hypomyelination (HP:0006808)2.43950620
56Spinal cord compression (HP:0002176)2.43093949
57Spinal rigidity (HP:0003306)2.42875798
58Elfin facies (HP:0004428)2.42032447
59Diminished motivation (HP:0000745)2.41435330
60Abnormality of the distal phalanges of the toes (HP:0010182)2.37037028
61Hypercortisolism (HP:0001578)2.36061462
62Megalencephaly (HP:0001355)2.35568322
63Unsteady gait (HP:0002317)2.35531973
64Long palpebral fissure (HP:0000637)2.34812755
65Febrile seizures (HP:0002373)2.34747496
66Stereotypic behavior (HP:0000733)2.33462817
67Progressive cerebellar ataxia (HP:0002073)2.32661379
68Back pain (HP:0003418)2.31183401
69Achilles tendon contracture (HP:0001771)2.29895053
70Thin bony cortex (HP:0002753)2.28780600
71Trismus (HP:0000211)2.28734735
72Renal duplication (HP:0000075)2.28029095
73Spinal canal stenosis (HP:0003416)2.27634090
74Elbow flexion contracture (HP:0002987)2.26320340
75Bradykinesia (HP:0002067)2.26259792
76Flat acetabular roof (HP:0003180)2.25863541
77Impaired pain sensation (HP:0007328)2.24995571
78Abnormality of pain sensation (HP:0010832)2.24995571
79Polyphagia (HP:0002591)2.23792837
80Ankyloglossia (HP:0010296)2.22411658
81Truncal ataxia (HP:0002078)2.21727965
82Urinary bladder sphincter dysfunction (HP:0002839)2.21540132
83Abnormality of dentin (HP:0010299)2.20575054
84Shallow orbits (HP:0000586)2.19262413
85Failure to thrive in infancy (HP:0001531)2.18368852
86Broad face (HP:0000283)2.16496523
87Long toe (HP:0010511)2.16487674
88Deep palmar crease (HP:0006191)2.16475622
89Wormian bones (HP:0002645)2.14335976
90Shoulder girdle muscle weakness (HP:0003547)2.13608656
91Poor suck (HP:0002033)2.11785004
92Hypoventilation (HP:0002791)2.11174353
93Mildly elevated creatine phosphokinase (HP:0008180)2.10744577
94Insomnia (HP:0100785)2.09719836
95Rapidly progressive (HP:0003678)2.08941855
96Mitral regurgitation (HP:0001653)2.08832687
97Cerebral aneurysm (HP:0004944)2.07812140
98Insidious onset (HP:0003587)2.06652804
99Termporal pattern (HP:0011008)2.06652804
100Increased connective tissue (HP:0009025)2.06340261
101Blue sclerae (HP:0000592)2.06066101
102Congenital glaucoma (HP:0001087)2.05650523
103Dysmetria (HP:0001310)2.05150230
104Polygenic inheritance (HP:0010982)2.04654941
105Dysdiadochokinesis (HP:0002075)2.04597580
106Cerebral inclusion bodies (HP:0100314)2.04596077
107Osteolytic defects of the hand bones (HP:0009699)2.04438098
108Osteolytic defects of the phalanges of the hand (HP:0009771)2.04438098
109Lower limb amyotrophy (HP:0007210)2.02161564
110Spastic gait (HP:0002064)2.00989828
111Athetosis (HP:0002305)1.98792432
112Generalized hypotonia (HP:0001290)1.98534784
113Postural instability (HP:0002172)1.96842206
114Emotional lability (HP:0000712)1.96133382
115Amyotrophic lateral sclerosis (HP:0007354)1.95568023
116Patellar dislocation (HP:0002999)1.92599037
117Natal tooth (HP:0000695)1.91650577
118Hand muscle atrophy (HP:0009130)1.91054617
119Abnormality of the Achilles tendon (HP:0005109)1.90424037
120Clonus (HP:0002169)1.90178981
121Biconcave vertebral bodies (HP:0004586)1.90100779
122Difficulty climbing stairs (HP:0003551)1.89370751
123Arterial tortuosity (HP:0005116)1.89103664
124Vascular tortuosity (HP:0004948)1.88156385
125Broad-based gait (HP:0002136)1.87917364
126Disproportionate tall stature (HP:0001519)1.86755111
127Generalized myoclonic seizures (HP:0002123)1.86418784
128Hypercalcemia (HP:0003072)1.85676120
129Generalized amyotrophy (HP:0003700)1.85230140
130Increased cerebral lipofuscin (HP:0011813)1.84561522
131Incomplete penetrance (HP:0003829)1.84386194
132Abnormality of the umbilical cord (HP:0010881)1.84368694
133Cholecystitis (HP:0001082)1.84351687
134Abnormal gallbladder physiology (HP:0012438)1.84351687
135Bundle branch block (HP:0011710)1.82967048
136Global brain atrophy (HP:0002283)1.82809862
137Neuronal loss in central nervous system (HP:0002529)1.82413438
138Advanced eruption of teeth (HP:0006288)1.81792965
139Entropion (HP:0000621)1.80304778
140Genu recurvatum (HP:0002816)1.80045229
141Renovascular hypertension (HP:0100817)1.79641842
142Epileptiform EEG discharges (HP:0011182)1.79075955
143Bowel diverticulosis (HP:0005222)1.78603014
144Flat cornea (HP:0007720)1.77937844
145Rigidity (HP:0002063)1.77910578
146Abnormality of oral frenula (HP:0000190)1.77578690
147Large eyes (HP:0001090)1.76103385
148Fetal akinesia sequence (HP:0001989)1.75833210
149Progressive muscle weakness (HP:0003323)1.75608003
150Hypsarrhythmia (HP:0002521)1.75286939
151Lower limb asymmetry (HP:0100559)1.75034419
152Microglossia (HP:0000171)1.74643282
153EEG with generalized epileptiform discharges (HP:0011198)1.74554325
154Multiple lipomas (HP:0001012)1.74383020
155Progressive inability to walk (HP:0002505)1.74355476
156Stridor (HP:0010307)1.74311517
157Axonal loss (HP:0003447)1.73942501
158Neurofibrillary tangles (HP:0002185)1.73808755
159Lower limb muscle weakness (HP:0007340)1.73783031
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.73633815
161Abnormal ossification of hand bones (HP:0005921)1.73454765
162Broad distal phalanx of finger (HP:0009836)1.73241928
163Abnormality of carpal bone ossification (HP:0006257)1.72393526
164Hyperparathyroidism (HP:0000843)1.70816707
165Protrusio acetabuli (HP:0003179)1.69971447
166Growth hormone excess (HP:0000845)1.68556267
167Selective tooth agenesis (HP:0001592)1.66974471
168Ragged-red muscle fibers (HP:0003200)1.65187607
169Syringomyelia (HP:0003396)1.64680530
170Spinal cord lesions (HP:0100561)1.64680530
171Arnold-Chiari malformation (HP:0002308)1.64145332
172Distal sensory impairment (HP:0002936)1.63587467
173Rough bone trabeculation (HP:0100670)1.63049517
174Hallux valgus (HP:0001822)1.62647117
175Centrally nucleated skeletal muscle fibers (HP:0003687)1.60967175
176Abdominal distention (HP:0003270)1.60212953
177Hypokinesia (HP:0002375)1.59915205
178Hyperextensible skin (HP:0000974)1.59816063
179Abnormality of glycosphingolipid metabolism (HP:0004343)1.56759847
180Abnormality of glycolipid metabolism (HP:0010969)1.56759847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.52394544
2MAP3K93.98782710
3ARAF3.49011310
4EPHA23.47629851
5NTRK33.32108378
6IRAK32.89535060
7SMG12.88761484
8MINK12.80189383
9KSR22.75939894
10SIK12.54714054
11EEF2K2.54323062
12DAPK22.42156242
13ICK2.40474011
14MAP3K122.39025969
15NEK12.24974569
16PRKD32.21259125
17CAMKK12.10835666
18DAPK12.03648048
19MARK11.99789609
20MST1R1.95884815
21TESK21.93777240
22NTRK11.91493993
23PRPF4B1.91459711
24PAK61.89575931
25TESK11.88056017
26LIMK11.80304499
27TAOK11.78222581
28TRIB31.74091376
29KSR11.72930664
30SCYL21.70499338
31CDK191.70289873
32ERN11.64325711
33PTK21.60423199
34RIPK41.53009512
35BRAF1.47216741
36RPS6KB21.42227007
37MAPKAPK31.39789658
38CDK51.39609206
39CAMKK21.37384531
40CDK141.37120055
41CDK181.36726451
42MET1.36248759
43RAF11.33153795
44CDK151.31537043
45BUB11.29724178
46MAP3K41.28452533
47TTN1.27938711
48BRSK11.27894176
49LATS21.27235390
50PLK21.22810715
51CDK11A1.19136938
52NTRK21.18398924
53MAP3K111.16962275
54MAP2K71.14366431
55GRK51.12614032
56PTK2B1.12491466
57UHMK11.08116415
58FES1.07917546
59MAP3K21.06974200
60EPHB21.06703763
61DAPK31.06502477
62TYRO31.01157350
63PRKCG1.01155921
64PTK60.98237648
65MAP3K130.96939940
66MAP2K10.96451334
67PIM20.96095248
68CCNB10.94615952
69MAP2K40.91986854
70PRKD20.86486670
71FGFR40.84231705
72MAP3K10.84132435
73PBK0.82939534
74CDK120.82749410
75MTOR0.81964602
76VRK20.81396308
77NME10.80646105
78PAK20.80492432
79ERBB40.79974651
80MOS0.79228384
81ALK0.75746565
82MAP2K20.74581823
83PRKG20.70716312
84MAP3K80.68816770
85SIK30.68800487
86PRKCI0.66323929
87CDK70.64649987
88RET0.64068043
89SIK20.63960159
90AKT20.63688367
91CAMK2B0.61300598
92STK380.60607533
93PKN20.58404369
94PDPK10.58235441
95CAMK10.55457350
96PAK10.54432548
97CAMK2A0.54271780
98LMTK20.53140116
99DDR20.52759554
100PAK30.52247015
101IRAK20.51847268
102MAP3K30.50745557
103ILK0.50724605
104MAPK130.50529025
105ROCK20.50072377
106ABL20.48256048
107PDGFRA0.47684718
108TAOK20.47067879
109CASK0.46715318
110PRKCH0.44008623
111FER0.42783017
112PDK10.42174036
113PRKCZ0.41128184
114MAP3K60.39161768
115CDK80.38337579
116RPS6KA20.38313851
117AURKA0.37722705
118EIF2AK10.36678730
119TNK20.35711188
120PAK40.35414719
121NEK60.34890856
122RPS6KA40.34782253
123CSNK1G20.34740892
124EPHB10.34740726
125TSSK60.31899573
126CAMK2G0.31196749
127MATK0.28623106
128BCR0.28322978
129PINK10.27952656
130NME20.27163739
131MAPK110.26984647
132CDC42BPA0.26910498
133MYLK0.26513987
134MAP2K30.26354989
135BMX0.26258531
136RIPK10.26154200
137CAMK2D0.26131226
138STK110.24895869
139FYN0.24825912
140TNIK0.24279309
141LRRK20.23682223

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.22673101
2Olfactory transduction_Homo sapiens_hsa047403.21150159
3Nicotine addiction_Homo sapiens_hsa050332.72934031
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.62148817
5Long-term potentiation_Homo sapiens_hsa047202.43780184
6Collecting duct acid secretion_Homo sapiens_hsa049662.40382780
7Amphetamine addiction_Homo sapiens_hsa050312.36316877
8GABAergic synapse_Homo sapiens_hsa047272.32506539
9Circadian entrainment_Homo sapiens_hsa047132.31047459
10Pentose phosphate pathway_Homo sapiens_hsa000302.28222623
11Dopaminergic synapse_Homo sapiens_hsa047282.18651709
12Biosynthesis of amino acids_Homo sapiens_hsa012302.13919776
13Morphine addiction_Homo sapiens_hsa050322.11981950
14Vibrio cholerae infection_Homo sapiens_hsa051102.10117104
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09279998
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02008678
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97767173
18Glutamatergic synapse_Homo sapiens_hsa047241.95905039
19Cocaine addiction_Homo sapiens_hsa050301.86490587
20Cholinergic synapse_Homo sapiens_hsa047251.79811990
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.70046360
22Other glycan degradation_Homo sapiens_hsa005111.66999384
23Salivary secretion_Homo sapiens_hsa049701.62416335
24Gap junction_Homo sapiens_hsa045401.60590638
25Sulfur relay system_Homo sapiens_hsa041221.58637087
26Gastric acid secretion_Homo sapiens_hsa049711.57295259
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.56707982
28Insulin secretion_Homo sapiens_hsa049111.55797663
29Chronic myeloid leukemia_Homo sapiens_hsa052201.51884789
30Parkinsons disease_Homo sapiens_hsa050121.49759323
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47534459
32Oxytocin signaling pathway_Homo sapiens_hsa049211.46274996
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.46083574
34Carbon metabolism_Homo sapiens_hsa012001.45962498
35Oxidative phosphorylation_Homo sapiens_hsa001901.43258107
36GnRH signaling pathway_Homo sapiens_hsa049121.38106792
37Glioma_Homo sapiens_hsa052141.37825724
38Oocyte meiosis_Homo sapiens_hsa041141.36950181
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35839786
40Proteasome_Homo sapiens_hsa030501.32269246
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30672638
42Long-term depression_Homo sapiens_hsa047301.30399750
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29545434
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22874758
45Serotonergic synapse_Homo sapiens_hsa047261.22625853
46Focal adhesion_Homo sapiens_hsa045101.18595971
47Proteoglycans in cancer_Homo sapiens_hsa052051.17050941
48Renin secretion_Homo sapiens_hsa049241.16759820
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16499517
50Calcium signaling pathway_Homo sapiens_hsa040201.14348157
51Cardiac muscle contraction_Homo sapiens_hsa042601.13876494
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12251629
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09186393
54Alzheimers disease_Homo sapiens_hsa050101.06882609
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06720215
56Taste transduction_Homo sapiens_hsa047421.05913566
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05151922
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02716316
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01680644
60VEGF signaling pathway_Homo sapiens_hsa043701.00917206
61Pancreatic cancer_Homo sapiens_hsa052120.99837329
62Estrogen signaling pathway_Homo sapiens_hsa049150.95578345
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95216686
64Small cell lung cancer_Homo sapiens_hsa052220.94879118
65Arginine biosynthesis_Homo sapiens_hsa002200.93883700
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.92806862
67ECM-receptor interaction_Homo sapiens_hsa045120.92779233
68AMPK signaling pathway_Homo sapiens_hsa041520.90070811
69ErbB signaling pathway_Homo sapiens_hsa040120.87605240
70Huntingtons disease_Homo sapiens_hsa050160.86656792
71Endocytosis_Homo sapiens_hsa041440.85283253
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84333092
73Hippo signaling pathway_Homo sapiens_hsa043900.82757532
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80757429
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80525756
76Adherens junction_Homo sapiens_hsa045200.79413973
77cAMP signaling pathway_Homo sapiens_hsa040240.79334348
78Acute myeloid leukemia_Homo sapiens_hsa052210.78528493
79Arginine and proline metabolism_Homo sapiens_hsa003300.77966151
80Notch signaling pathway_Homo sapiens_hsa043300.77632589
81Shigellosis_Homo sapiens_hsa051310.74709739
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74531234
83Phagosome_Homo sapiens_hsa041450.74395733
84Tight junction_Homo sapiens_hsa045300.73811961
85Melanogenesis_Homo sapiens_hsa049160.73582257
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72036849
87Bladder cancer_Homo sapiens_hsa052190.71818557
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.70179490
89Non-small cell lung cancer_Homo sapiens_hsa052230.69522711
90Folate biosynthesis_Homo sapiens_hsa007900.68305634
91Axon guidance_Homo sapiens_hsa043600.68083778
92Alcoholism_Homo sapiens_hsa050340.67569037
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67511027
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.66272684
95Apoptosis_Homo sapiens_hsa042100.65949315
96Amoebiasis_Homo sapiens_hsa051460.64505771
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64277701
98DNA replication_Homo sapiens_hsa030300.63955599
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63652170
100Prion diseases_Homo sapiens_hsa050200.62243371
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62208167
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61687726
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61646189
104Phenylalanine metabolism_Homo sapiens_hsa003600.61168545
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60964605
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60800454
107Thyroid hormone synthesis_Homo sapiens_hsa049180.59102684
108Thyroid cancer_Homo sapiens_hsa052160.58590114
109Glutathione metabolism_Homo sapiens_hsa004800.57825896
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.57532503
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57310193
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57047140
113MicroRNAs in cancer_Homo sapiens_hsa052060.56451007
114Type I diabetes mellitus_Homo sapiens_hsa049400.55083217
115Melanoma_Homo sapiens_hsa052180.54359464
116* Lysosome_Homo sapiens_hsa041420.54245261
117Fructose and mannose metabolism_Homo sapiens_hsa000510.54150745
118N-Glycan biosynthesis_Homo sapiens_hsa005100.53877877
119Rheumatoid arthritis_Homo sapiens_hsa053230.53825850
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53431953
121Pyruvate metabolism_Homo sapiens_hsa006200.52507624
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52204082
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51784096
124Rap1 signaling pathway_Homo sapiens_hsa040150.51002238
125Hepatitis C_Homo sapiens_hsa051600.50990505
126Inositol phosphate metabolism_Homo sapiens_hsa005620.50353532
127Viral carcinogenesis_Homo sapiens_hsa052030.49311623
128Sulfur metabolism_Homo sapiens_hsa009200.49102736
129Salmonella infection_Homo sapiens_hsa051320.48485632
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47852191
131Colorectal cancer_Homo sapiens_hsa052100.45575204
132Glucagon signaling pathway_Homo sapiens_hsa049220.45342202
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45131927
134Vitamin B6 metabolism_Homo sapiens_hsa007500.44831835
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.43014912
136Endometrial cancer_Homo sapiens_hsa052130.42759325
137Prostate cancer_Homo sapiens_hsa052150.42642842
138Type II diabetes mellitus_Homo sapiens_hsa049300.42569697
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.42385668
140HIF-1 signaling pathway_Homo sapiens_hsa040660.42274089
141Base excision repair_Homo sapiens_hsa034100.42060536
142mTOR signaling pathway_Homo sapiens_hsa041500.41012491
143Pancreatic secretion_Homo sapiens_hsa049720.40426902
144MAPK signaling pathway_Homo sapiens_hsa040100.40217808
145Dilated cardiomyopathy_Homo sapiens_hsa054140.39997335
146Regulation of autophagy_Homo sapiens_hsa041400.39077641
147Renal cell carcinoma_Homo sapiens_hsa052110.38782022
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38611195
149Ras signaling pathway_Homo sapiens_hsa040140.37277065
150Insulin signaling pathway_Homo sapiens_hsa049100.37042745
151Galactose metabolism_Homo sapiens_hsa000520.36515552
152Choline metabolism in cancer_Homo sapiens_hsa052310.35205084
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32144063

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