AP1S3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.02598011
2central nervous system myelination (GO:0022010)6.02598011
3neuron cell-cell adhesion (GO:0007158)4.93188811
4histone H2B ubiquitination (GO:0033523)4.82683518
5behavioral response to nicotine (GO:0035095)4.71626691
6presynaptic membrane assembly (GO:0097105)4.44745305
7presynaptic membrane organization (GO:0097090)4.16831321
8response to pheromone (GO:0019236)4.14789744
9limb bud formation (GO:0060174)4.12422002
10kidney morphogenesis (GO:0060993)4.02919539
11water-soluble vitamin biosynthetic process (GO:0042364)3.99945019
12kynurenine metabolic process (GO:0070189)3.92369607
13fucose catabolic process (GO:0019317)3.89353128
14L-fucose metabolic process (GO:0042354)3.89353128
15L-fucose catabolic process (GO:0042355)3.89353128
16DNA deamination (GO:0045006)3.88135262
17long-chain fatty acid biosynthetic process (GO:0042759)3.85952320
18respiratory chain complex IV assembly (GO:0008535)3.80510062
19righting reflex (GO:0060013)3.80229056
20cell fate commitment involved in formation of primary germ layer (GO:0060795)3.73058349
21transmission of nerve impulse (GO:0019226)3.67866907
22platelet dense granule organization (GO:0060155)3.67254528
23dopamine transport (GO:0015872)3.62428389
24neuron remodeling (GO:0016322)3.60082186
25fatty acid elongation (GO:0030497)3.52339629
26indolalkylamine metabolic process (GO:0006586)3.51399216
27indole-containing compound catabolic process (GO:0042436)3.50366160
28indolalkylamine catabolic process (GO:0046218)3.50366160
29tryptophan catabolic process (GO:0006569)3.50366160
30protein-cofactor linkage (GO:0018065)3.48488479
31myelination (GO:0042552)3.42687567
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.41077611
33dendritic spine morphogenesis (GO:0060997)3.38382363
34ensheathment of neurons (GO:0007272)3.38276596
35axon ensheathment (GO:0008366)3.38276596
36neuron recognition (GO:0008038)3.35545879
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.34979026
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.34279445
39regulation of timing of cell differentiation (GO:0048505)3.31983987
40protein complex biogenesis (GO:0070271)3.31803075
41positive regulation of action potential (GO:0045760)3.30780012
42glycerophospholipid catabolic process (GO:0046475)3.30572603
43keratinocyte development (GO:0003334)3.30513294
44cytochrome complex assembly (GO:0017004)3.29476927
45positive regulation of synapse assembly (GO:0051965)3.29206181
46vocalization behavior (GO:0071625)3.28134276
47cerebral cortex radially oriented cell migration (GO:0021799)3.24066632
48postsynaptic membrane organization (GO:0001941)3.23765687
49glutamate receptor signaling pathway (GO:0007215)3.22828824
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.19355245
51NADH dehydrogenase complex assembly (GO:0010257)3.19355245
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19355245
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15951016
54maturation of 5.8S rRNA (GO:0000460)3.15545423
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14200677
56mitochondrial respiratory chain complex assembly (GO:0033108)3.13669682
57positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.13035186
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12701624
59tryptophan metabolic process (GO:0006568)3.12575223
60L-amino acid import (GO:0043092)3.12163979
61magnesium ion transport (GO:0015693)3.11976012
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09090551
63retina layer formation (GO:0010842)3.09077736
64import into cell (GO:0098657)3.07697889
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05183188
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04675873
67negative regulation of execution phase of apoptosis (GO:1900118)3.04640130
68replication fork processing (GO:0031297)3.04093252
69short-term memory (GO:0007614)3.03089721
70preassembly of GPI anchor in ER membrane (GO:0016254)3.02968600
71oligodendrocyte differentiation (GO:0048709)3.00912988
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.00577887
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00135787
74ATP synthesis coupled proton transport (GO:0015986)3.00135787
75eye photoreceptor cell differentiation (GO:0001754)3.00104798
76photoreceptor cell differentiation (GO:0046530)3.00104798
77neural tube formation (GO:0001841)2.98639355
78negative regulation of neurotransmitter transport (GO:0051589)2.98260804
79regulation of memory T cell differentiation (GO:0043380)2.97459347
80neuronal action potential propagation (GO:0019227)2.96690597
81regulation of feeding behavior (GO:0060259)2.95844345
82anterograde synaptic vesicle transport (GO:0048490)2.94137427
83startle response (GO:0001964)2.92308295
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88200123
85lateral sprouting from an epithelium (GO:0060601)2.88050948
86protein localization to synapse (GO:0035418)2.87865055
87rRNA catabolic process (GO:0016075)2.87468318
88negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85162351
89pseudouridine synthesis (GO:0001522)2.85002861
90negative regulation of protein localization to cell surface (GO:2000009)2.83282960
91protein K11-linked deubiquitination (GO:0035871)2.82689191
92negative regulation of mast cell activation (GO:0033004)2.81756771
93recombinational repair (GO:0000725)2.81292752
94cellular response to epinephrine stimulus (GO:0071872)2.81229708
95nonmotile primary cilium assembly (GO:0035058)2.81173467
96cranial nerve morphogenesis (GO:0021602)2.80966634
97reflex (GO:0060004)2.80421510
98double-strand break repair via homologous recombination (GO:0000724)2.78739707
99positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77914655
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.76452414
101negative regulation of neurotransmitter secretion (GO:0046929)2.75938407
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74037754
103regulation of development, heterochronic (GO:0040034)2.73935927
104reciprocal DNA recombination (GO:0035825)2.72985125
105reciprocal meiotic recombination (GO:0007131)2.72985125
106regulation of mRNA 3-end processing (GO:0031440)2.72902740
107cranial nerve development (GO:0021545)2.72657066
108organ growth (GO:0035265)2.71756935
109amino acid salvage (GO:0043102)2.71078675
110L-methionine salvage (GO:0071267)2.71078675
111L-methionine biosynthetic process (GO:0071265)2.71078675
112protein palmitoylation (GO:0018345)2.70858879
113indole-containing compound metabolic process (GO:0042430)2.70709314
114negative regulation of telomere maintenance (GO:0032205)2.70539465
115axonal fasciculation (GO:0007413)2.70354092
116somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.70302412
117isotype switching (GO:0045190)2.70302412
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.70302412
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70112869
120detection of light stimulus involved in visual perception (GO:0050908)2.70037055
121detection of light stimulus involved in sensory perception (GO:0050962)2.70037055
122cellular ketone body metabolic process (GO:0046950)2.69711206
123ubiquinone biosynthetic process (GO:0006744)2.68872671
124positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.68463604
125tRNA processing (GO:0008033)2.68141322
126regulation of hexokinase activity (GO:1903299)2.68077835
127regulation of glucokinase activity (GO:0033131)2.68077835
128head development (GO:0060322)2.67428818
129response to epinephrine (GO:0071871)2.66296519
130protein neddylation (GO:0045116)2.64837340
131nucleobase biosynthetic process (GO:0046112)2.62454689
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62417470
133adult feeding behavior (GO:0008343)2.61573610
134transcription elongation from RNA polymerase III promoter (GO:0006385)2.61018597
135termination of RNA polymerase III transcription (GO:0006386)2.61018597
136positive regulation of defense response to virus by host (GO:0002230)2.60183574
137base-excision repair, AP site formation (GO:0006285)2.59154504
138replicative senescence (GO:0090399)2.59009806
139neuronal ion channel clustering (GO:0045161)2.58837112
140regulation of synapse assembly (GO:0051963)2.58433974
141regulation of hippo signaling (GO:0035330)2.57988206
142mitochondrial RNA metabolic process (GO:0000959)2.57784938
143establishment of protein localization to mitochondrial membrane (GO:0090151)2.57431818
144amino acid import (GO:0043090)2.57228089
145DNA double-strand break processing (GO:0000729)2.56757368
146regulation of collateral sprouting (GO:0048670)2.56718893
147piRNA metabolic process (GO:0034587)2.56551978
148cellular response to exogenous dsRNA (GO:0071360)2.56398013
149dopamine biosynthetic process (GO:0042416)2.55355553
150positive regulation of dendritic spine development (GO:0060999)2.54915350
151DNA demethylation (GO:0080111)2.54099675
152meiotic chromosome segregation (GO:0045132)2.53250377
153mannosylation (GO:0097502)2.53210277
154regulation of somitogenesis (GO:0014807)2.52680179
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.52561637
156tRNA modification (GO:0006400)2.51441228
157ubiquinone metabolic process (GO:0006743)2.51328699
158lens fiber cell development (GO:0070307)2.51102068
159methionine biosynthetic process (GO:0009086)2.51051435
160adult walking behavior (GO:0007628)2.51022394
161polyol transport (GO:0015791)2.50149445
162neuron-neuron synaptic transmission (GO:0007270)2.49867985
163negative regulation of Rho protein signal transduction (GO:0035024)2.49217645
164regulation of glutamate secretion (GO:0014048)2.48968682
165response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.48719539
166peptidyl-histidine modification (GO:0018202)2.48182635
167ketone body metabolic process (GO:1902224)2.46608893
168G-protein coupled receptor internalization (GO:0002031)2.45223687
169regulation of platelet aggregation (GO:0090330)2.44548194
170positive regulation of meiosis (GO:0045836)2.44151336
171cell morphogenesis involved in neuron differentiation (GO:0048667)2.43415173
172serotonin metabolic process (GO:0042428)2.43017823
173regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.42681911
174tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42297510
175RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42297510
176GPI anchor metabolic process (GO:0006505)2.42285221
177somatic diversification of immune receptors via somatic mutation (GO:0002566)2.42155259
178somatic hypermutation of immunoglobulin genes (GO:0016446)2.42155259
179cilium movement (GO:0003341)2.41687785
180ventricular system development (GO:0021591)2.41359043
181spinal cord motor neuron differentiation (GO:0021522)2.40911611
182primary amino compound metabolic process (GO:1901160)2.40882097
183regulation of mesoderm development (GO:2000380)2.40528352
184opioid receptor signaling pathway (GO:0038003)2.40347255
185organelle disassembly (GO:1903008)2.40055723
186developmental pigmentation (GO:0048066)2.39940325
187RNA destabilization (GO:0050779)2.39697218
188regulation of glutamate receptor signaling pathway (GO:1900449)2.38900616
189mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38713558
190regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36827217
191synaptic transmission, glutamatergic (GO:0035249)2.36277418
192regulation of dendritic spine development (GO:0060998)2.33953850
193positive regulation of meiotic cell cycle (GO:0051446)2.33623002
194membrane assembly (GO:0071709)2.32966861
195axonemal dynein complex assembly (GO:0070286)2.32917475
196regulation of respiratory system process (GO:0044065)2.32415099
197regulation of excitatory postsynaptic membrane potential (GO:0060079)2.31554587
198neurotransmitter catabolic process (GO:0042135)2.31456273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.17074052
2ZNF274_21170338_ChIP-Seq_K562_Hela3.92815896
3GBX2_23144817_ChIP-Seq_PC3_Human3.47110638
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07486936
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.03998977
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83766036
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83144467
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61390850
9TAF15_26573619_Chip-Seq_HEK293_Human2.61024004
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54865588
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54755612
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.54478777
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47340246
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.46924048
15* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41668993
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40180687
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.35558907
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32683583
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29196215
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28541775
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25339467
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25339467
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22287823
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.22078663
25ELK1_19687146_ChIP-ChIP_HELA_Human2.19518374
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19089134
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14735900
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08615787
29MYC_18940864_ChIP-ChIP_HL60_Human2.01693664
30VDR_22108803_ChIP-Seq_LS180_Human2.00495563
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98825487
32AR_21572438_ChIP-Seq_LNCaP_Human1.96001709
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95971418
34* EZH2_27294783_Chip-Seq_ESCs_Mouse1.95086254
35VDR_23849224_ChIP-Seq_CD4+_Human1.94540774
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90478474
37* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88266959
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88266817
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86502203
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.85780976
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.83147954
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82272607
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78077303
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74464712
45* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72715183
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72630431
47P300_19829295_ChIP-Seq_ESCs_Human1.71143901
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70583537
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70269372
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68827245
51IRF1_19129219_ChIP-ChIP_H3396_Human1.68082461
52RNF2_27304074_Chip-Seq_NSC_Mouse1.67310889
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66193988
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.65853620
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65799067
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64081997
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62429463
58* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62056564
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.60694491
60* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58507857
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55872672
62CBP_20019798_ChIP-Seq_JUKART_Human1.55872672
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55274777
64* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54399004
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52924707
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.52728484
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52728484
68* FLI1_27457419_Chip-Seq_LIVER_Mouse1.52399280
69FUS_26573619_Chip-Seq_HEK293_Human1.51085838
70TP53_22573176_ChIP-Seq_HFKS_Human1.51060264
71SMAD4_21799915_ChIP-Seq_A2780_Human1.50025873
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.49863110
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49488785
74DROSHA_22980978_ChIP-Seq_HELA_Human1.48896210
75* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46862104
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44748976
77REST_21632747_ChIP-Seq_MESCs_Mouse1.44240069
78BCAT_22108803_ChIP-Seq_LS180_Human1.43982680
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41437951
80* NFE2_27457419_Chip-Seq_LIVER_Mouse1.41273105
81ER_23166858_ChIP-Seq_MCF-7_Human1.40802773
82* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38853291
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38680452
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38421720
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37512395
86* EZH2_27294783_Chip-Seq_NPCs_Mouse1.37195460
87IGF1R_20145208_ChIP-Seq_DFB_Human1.36564024
88* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32250211
89* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32194093
90* TCF4_22108803_ChIP-Seq_LS180_Human1.32127468
91HOXB7_26014856_ChIP-Seq_BT474_Human1.31440169
92* CMYC_18555785_Chip-Seq_ESCs_Mouse1.31364862
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30286469
94* P53_22387025_ChIP-Seq_ESCs_Mouse1.30076495
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29908012
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.29857239
97* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28831692
98AR_25329375_ChIP-Seq_VCAP_Human1.28276269
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.28003859
100* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27878260
101* P300_18555785_Chip-Seq_ESCs_Mouse1.27724597
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27421974
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26213895
104FOXP3_21729870_ChIP-Seq_TREG_Human1.26026096
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25505687
106SOX2_19829295_ChIP-Seq_ESCs_Human1.25393190
107NANOG_19829295_ChIP-Seq_ESCs_Human1.25393190
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23336878
109AR_20517297_ChIP-Seq_VCAP_Human1.22006303
110* STAT3_18555785_Chip-Seq_ESCs_Mouse1.21306912
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20574525
112NCOR_22424771_ChIP-Seq_293T_Human1.20249715
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18745249
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18075713
115* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17943439
116RUNX2_22187159_ChIP-Seq_PCA_Human1.17210020
117GATA3_21878914_ChIP-Seq_MCF-7_Human1.16549982
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16029174
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16029174
120* NMYC_18555785_Chip-Seq_ESCs_Mouse1.14379448
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14037847
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13723939
123* CDX2_22108803_ChIP-Seq_LS180_Human1.12905691
124STAT3_23295773_ChIP-Seq_U87_Human1.12808304
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12647047
126* TP53_18474530_ChIP-ChIP_U2OS_Human1.12563817
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12505484
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12325378
129* TAL1_26923725_Chip-Seq_HPCs_Mouse1.11903895
130* OCT4_18555785_Chip-Seq_ESCs_Mouse1.11784694
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11619508
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11002803
133* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10449883
134IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09837474
135TP53_16413492_ChIP-PET_HCT116_Human1.09604253
136* SOX2_18555785_Chip-Seq_ESCs_Mouse1.09333255
137KDM2B_26808549_Chip-Seq_REH_Human1.09084292
138* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08723331
139EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08532196
140* KLF4_18555785_Chip-Seq_ESCs_Mouse1.08518449
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07403967
142* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07297870
143EWS_26573619_Chip-Seq_HEK293_Human1.05504495
144WT1_19549856_ChIP-ChIP_CCG9911_Human1.05153429
145E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04934440
146P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04810413
147GATA3_26560356_Chip-Seq_TH2_Human1.04709194
148CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04673790
149* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04246357
150* SMAD4_21741376_ChIP-Seq_EPCs_Human1.03547191
151* ZFX_18555785_Chip-Seq_ESCs_Mouse1.03271389
152* TCF4_23295773_ChIP-Seq_U87_Human1.03115337
153E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00076631
154NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99668730
155ELK1_22589737_ChIP-Seq_MCF10A_Human0.99375164
156CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99207199
157* CRX_20693478_ChIP-Seq_RETINA_Mouse0.97318269
158ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96362522
159CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95996049
160FLI1_21867929_ChIP-Seq_TH2_Mouse0.94282172
161FOXH1_21741376_ChIP-Seq_EPCs_Human0.93603279
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92213625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.29397859
2MP0003136_yellow_coat_color3.33802634
3MP0002102_abnormal_ear_morphology3.02451357
4MP0005423_abnormal_somatic_nervous2.86771058
5MP0001188_hyperpigmentation2.72708347
6MP0001486_abnormal_startle_reflex2.65112799
7MP0003195_calcinosis2.63549190
8MP0004742_abnormal_vestibular_system2.57692092
9MP0008875_abnormal_xenobiotic_pharmacok2.56920237
10MP0005379_endocrine/exocrine_gland_phen2.54759842
11MP0005409_darkened_coat_color2.47437405
12MP0000569_abnormal_digit_pigmentation2.42023588
13MP0004381_abnormal_hair_follicle2.38081426
14MP0008877_abnormal_DNA_methylation2.36695512
15MP0009046_muscle_twitch2.30605439
16MP0002837_dystrophic_cardiac_calcinosis2.27366481
17MP0008058_abnormal_DNA_repair2.24439690
18MP0004270_analgesia2.24009072
19MP0009745_abnormal_behavioral_response2.21977246
20MP0001873_stomach_inflammation2.20222236
21MP0000566_synostosis2.18047016
22MP0002876_abnormal_thyroid_physiology2.16100991
23MP0008872_abnormal_physiological_respon2.14137956
24MP0001440_abnormal_grooming_behavior2.13951289
25MP0004142_abnormal_muscle_tone2.12852155
26MP0003635_abnormal_synaptic_transmissio2.12334082
27MP0002272_abnormal_nervous_system2.05700804
28MP0003718_maternal_effect2.04079948
29MP0002064_seizures2.01244327
30MP0006072_abnormal_retinal_apoptosis1.98578414
31MP0001968_abnormal_touch/_nociception1.98462155
32MP0000920_abnormal_myelination1.95898782
33MP0005451_abnormal_body_composition1.95506040
34MP0000462_abnormal_digestive_system1.95064889
35MP0006276_abnormal_autonomic_nervous1.94236428
36MP0001529_abnormal_vocalization1.93161793
37MP0000778_abnormal_nervous_system1.90866761
38MP0003646_muscle_fatigue1.89598470
39MP0002572_abnormal_emotion/affect_behav1.87622623
40MP0004859_abnormal_synaptic_plasticity1.86263073
41MP0000383_abnormal_hair_follicle1.80757904
42MP0005084_abnormal_gallbladder_morpholo1.75135163
43MP0002067_abnormal_sensory_capabilities1.73417534
44MP0006292_abnormal_olfactory_placode1.73035983
45MP0003252_abnormal_bile_duct1.72248926
46MP0002928_abnormal_bile_duct1.71714494
47MP0003938_abnormal_ear_development1.69122750
48MP0001905_abnormal_dopamine_level1.68410192
49MP0005645_abnormal_hypothalamus_physiol1.68232990
50MP0005551_abnormal_eye_electrophysiolog1.67966506
51MP0004043_abnormal_pH_regulation1.66965222
52MP0002734_abnormal_mechanical_nocicepti1.66008831
53MP0001727_abnormal_embryo_implantation1.63994849
54MP0009697_abnormal_copulation1.63257363
55MP0001501_abnormal_sleep_pattern1.61562731
56MP0002736_abnormal_nociception_after1.60157252
57MP0010094_abnormal_chromosome_stability1.58400510
58MP0005171_absent_coat_pigmentation1.57541101
59MP0002735_abnormal_chemical_nociception1.57284228
60MP0000026_abnormal_inner_ear1.57092739
61MP0008057_abnormal_DNA_replication1.57060362
62MP0002234_abnormal_pharynx_morphology1.56054064
63MP0002063_abnormal_learning/memory/cond1.55498329
64MP0001485_abnormal_pinna_reflex1.51722976
65MP0009379_abnormal_foot_pigmentation1.51173221
66MP0001963_abnormal_hearing_physiology1.46044639
67MP0002184_abnormal_innervation1.40298491
68MP0002938_white_spotting1.38369659
69MP0003693_abnormal_embryo_hatching1.37863559
70MP0002557_abnormal_social/conspecific_i1.37653141
71MP0002752_abnormal_somatic_nervous1.34635866
72MP0000631_abnormal_neuroendocrine_gland1.33817621
73MP0003786_premature_aging1.32532148
74MP0000372_irregular_coat_pigmentation1.32051567
75MP0002249_abnormal_larynx_morphology1.30769929
76MP0002277_abnormal_respiratory_mucosa1.29706913
77MP0010678_abnormal_skin_adnexa1.29407758
78MP0003011_delayed_dark_adaptation1.27025577
79MP0004885_abnormal_endolymph1.26746900
80MP0005389_reproductive_system_phenotype1.24802627
81MP0001970_abnormal_pain_threshold1.24140367
82MP0005623_abnormal_meninges_morphology1.23612804
83MP0002882_abnormal_neuron_morphology1.19593572
84MP0002160_abnormal_reproductive_system1.18510506
85MP0002138_abnormal_hepatobiliary_system1.17207679
86MP0000762_abnormal_tongue_morphology1.16179682
87MP0005167_abnormal_blood-brain_barrier1.14777666
88MP0002733_abnormal_thermal_nociception1.14681447
89MP0003690_abnormal_glial_cell1.13889460
90MP0006082_CNS_inflammation1.13308388
91MP0005253_abnormal_eye_physiology1.12083192
92MP0005410_abnormal_fertilization1.11850865
93MP0005332_abnormal_amino_acid1.10538895
94MP0002693_abnormal_pancreas_physiology1.10218270
95MP0002095_abnormal_skin_pigmentation1.08560490
96MP0001919_abnormal_reproductive_system1.08541566
97MP0003941_abnormal_skin_development1.07572449
98MP0000049_abnormal_middle_ear1.07179966
99MP0008961_abnormal_basal_metabolism1.07135072
100MP0001986_abnormal_taste_sensitivity1.06652103
101MP0000955_abnormal_spinal_cord1.05920722
102MP0002210_abnormal_sex_determination1.04845577
103MP0002229_neurodegeneration1.03650702
104MP0009250_abnormal_appendicular_skeleto1.03027153
105MP0001661_extended_life_span1.01209063
106MP0003806_abnormal_nucleotide_metabolis1.00986198
107MP0002066_abnormal_motor_capabilities/c0.99031631
108MP0004147_increased_porphyrin_level0.98241232
109MP0000613_abnormal_salivary_gland0.97656164
110MP0005367_renal/urinary_system_phenotyp0.97018731
111MP0000516_abnormal_urinary_system0.97018731
112MP0005646_abnormal_pituitary_gland0.96099268
113MP0000579_abnormal_nail_morphology0.95026730
114MP0001984_abnormal_olfaction0.93725112
115MP0005085_abnormal_gallbladder_physiolo0.93545882
116MP0005386_behavior/neurological_phenoty0.93474858
117MP0004924_abnormal_behavior0.93474858
118MP0003950_abnormal_plasma_membrane0.91933493
119MP0005671_abnormal_response_to0.91869825
120MP0000647_abnormal_sebaceous_gland0.91586305
121MP0003634_abnormal_glial_cell0.91195021
122MP0005310_abnormal_salivary_gland0.90518418
123MP0001293_anophthalmia0.88697423
124MP0003186_abnormal_redox_activity0.88369071
125MP0003937_abnormal_limbs/digits/tail_de0.88010961
126MP0004145_abnormal_muscle_electrophysio0.87990062
127MP0009764_decreased_sensitivity_to0.87485870
128MP0010386_abnormal_urinary_bladder0.85225947
129MP0005195_abnormal_posterior_eye0.84996903
130MP0008775_abnormal_heart_ventricle0.84352049
131MP0001929_abnormal_gametogenesis0.82637104
132MP0002653_abnormal_ependyma_morphology0.82330158
133MP0001764_abnormal_homeostasis0.82120691
134MP0001324_abnormal_eye_pigmentation0.81552834
135MP0001664_abnormal_digestion0.81305080
136MP0001502_abnormal_circadian_rhythm0.81078283
137MP0002152_abnormal_brain_morphology0.79637087
138MP0000427_abnormal_hair_cycle0.79376059
139MP0000653_abnormal_sex_gland0.79079032
140MP0000230_abnormal_systemic_arterial0.78323423
141MP0006036_abnormal_mitochondrial_physio0.77528728
142MP0002909_abnormal_adrenal_gland0.75843237
143MP0008569_lethality_at_weaning0.74977914
144MP0003890_abnormal_embryonic-extraembry0.74049642
145MP0001346_abnormal_lacrimal_gland0.73455367
146MP0005395_other_phenotype0.72419863
147MP0008995_early_reproductive_senescence0.72188536
148MP0001119_abnormal_female_reproductive0.71931839
149MP0008789_abnormal_olfactory_epithelium0.71685556
150MP0000538_abnormal_urinary_bladder0.71527712
151MP0003787_abnormal_imprinting0.70900646
152MP0003119_abnormal_digestive_system0.70646822
153MP0005391_vision/eye_phenotype0.70500723
154MP0002163_abnormal_gland_morphology0.66319125
155MP0003385_abnormal_body_wall0.66015968
156MP0002233_abnormal_nose_morphology0.65990714
157MP0005174_abnormal_tail_pigmentation0.63508316
158MP0000470_abnormal_stomach_morphology0.63240130
159MP0002177_abnormal_outer_ear0.63212956
160MP0002751_abnormal_autonomic_nervous0.60900819
161MP0004133_heterotaxia0.60464953
162MP0003122_maternal_imprinting0.59517950

Predicted human phenotypes

RankGene SetZ-score
1Upper limb muscle weakness (HP:0003484)5.12093734
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.55778328
3Absent/shortened dynein arms (HP:0200106)4.53263711
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.53263711
5Pancreatic cysts (HP:0001737)4.33073605
6Abnormal ciliary motility (HP:0012262)4.18259130
7Parakeratosis (HP:0001036)3.93962907
8Abnormality of the parathyroid morphology (HP:0011766)3.88791103
9True hermaphroditism (HP:0010459)3.85313712
10Pancreatic fibrosis (HP:0100732)3.82284449
11Abnormality of midbrain morphology (HP:0002418)3.80596427
12Molar tooth sign on MRI (HP:0002419)3.80596427
13Abnormal respiratory motile cilium physiology (HP:0012261)3.68058628
14Abnormal respiratory motile cilium morphology (HP:0005938)3.53598265
15Abnormal respiratory epithelium morphology (HP:0012253)3.53598265
16Focal motor seizures (HP:0011153)3.30764071
17Pendular nystagmus (HP:0012043)3.15714351
18Congenital, generalized hypertrichosis (HP:0004540)3.14152485
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.12675092
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12675092
21Febrile seizures (HP:0002373)3.05000791
22Abnormality of the axillary hair (HP:0100134)3.03730553
23Abnormality of secondary sexual hair (HP:0009888)3.03730553
24Congenital stationary night blindness (HP:0007642)2.97336087
25Medial flaring of the eyebrow (HP:0010747)2.96746410
26Abnormality of the renal cortex (HP:0011035)2.92976443
27Septo-optic dysplasia (HP:0100842)2.92680913
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91978334
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90371841
30Abnormality of alanine metabolism (HP:0010916)2.90371841
31Hyperalaninemia (HP:0003348)2.90371841
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.85819274
33Sensory axonal neuropathy (HP:0003390)2.85634575
34Concave nail (HP:0001598)2.80248214
35Type II lissencephaly (HP:0007260)2.78748727
36Tubular atrophy (HP:0000092)2.70793078
37Lipid accumulation in hepatocytes (HP:0006561)2.70423849
38Neurofibrillary tangles (HP:0002185)2.69545107
39Duplicated collecting system (HP:0000081)2.67730838
40Atelectasis (HP:0100750)2.67075831
41Abolished electroretinogram (ERG) (HP:0000550)2.63973976
42Abnormality of the pons (HP:0007361)2.60595638
43Chin dimple (HP:0010751)2.60316400
44Increased CSF lactate (HP:0002490)2.59735185
45Aplasia cutis congenita (HP:0001057)2.57293858
46Sclerocornea (HP:0000647)2.55088043
47Peripheral hypomyelination (HP:0007182)2.50397181
48Hypoplasia of the pons (HP:0012110)2.49165129
49Mitochondrial inheritance (HP:0001427)2.46293385
50Increased hepatocellular lipid droplets (HP:0006565)2.46136791
51Abnormal drinking behavior (HP:0030082)2.43338719
52Polydipsia (HP:0001959)2.43338719
53Onion bulb formation (HP:0003383)2.39897294
54Chromsome breakage (HP:0040012)2.36477711
55Progressive inability to walk (HP:0002505)2.36348537
56Absent septum pellucidum (HP:0001331)2.35868717
57Cystic liver disease (HP:0006706)2.34340197
583-Methylglutaconic aciduria (HP:0003535)2.32558028
59Atonic seizures (HP:0010819)2.32359839
60Broad-based gait (HP:0002136)2.32009618
61Congenital primary aphakia (HP:0007707)2.31855780
62Abnormal rod and cone electroretinograms (HP:0008323)2.31290744
63Gait imbalance (HP:0002141)2.30688340
64Nephroblastoma (Wilms tumor) (HP:0002667)2.29487461
65Chronic hepatic failure (HP:0100626)2.28859098
66Duplication of thumb phalanx (HP:0009942)2.25481907
67Increased serum lactate (HP:0002151)2.25257960
68Furrowed tongue (HP:0000221)2.25208828
69Cupped ear (HP:0000378)2.25081987
70Focal seizures (HP:0007359)2.24805040
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.24642187
72Congenital sensorineural hearing impairment (HP:0008527)2.24406207
73Hypothermia (HP:0002045)2.24058569
74Partial agenesis of the corpus callosum (HP:0001338)2.23660165
75Abnormality of the corticospinal tract (HP:0002492)2.23580162
76Overfolded helix (HP:0000396)2.23390273
77Acute necrotizing encephalopathy (HP:0006965)2.23146100
78Abnormality of the renal collecting system (HP:0004742)2.23082543
79Nephrogenic diabetes insipidus (HP:0009806)2.21170951
80Inability to walk (HP:0002540)2.20558695
81Decreased central vision (HP:0007663)2.20135718
82Hepatocellular necrosis (HP:0001404)2.19026821
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.17898079
84Alacrima (HP:0000522)2.17107445
85White forelock (HP:0002211)2.16069845
86Abnormality of the septum pellucidum (HP:0007375)2.15397109
87Embryonal renal neoplasm (HP:0011794)2.15081255
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13773318
89Hypophosphatemic rickets (HP:0004912)2.11437428
90Esotropia (HP:0000565)2.11293429
91Hyperventilation (HP:0002883)2.11273618
92Large for gestational age (HP:0001520)2.10515313
93Aplasia/hypoplasia of the uterus (HP:0008684)2.09532148
94Polyuria (HP:0000103)2.06252440
95Metabolic alkalosis (HP:0200114)2.06069526
96Acute encephalopathy (HP:0006846)2.05943684
97Chorioretinal atrophy (HP:0000533)2.04131813
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.02384587
99Absent speech (HP:0001344)2.02196051
100Cerebellar dysplasia (HP:0007033)2.02088283
101Lissencephaly (HP:0001339)2.02056428
102Nephronophthisis (HP:0000090)2.01889894
103Synostosis involving the elbow (HP:0003938)2.01817628
104Humeroradial synostosis (HP:0003041)2.01817628
105Hepatic necrosis (HP:0002605)2.01661102
106Decreased lacrimation (HP:0000633)2.01413677
107Patchy hypopigmentation of hair (HP:0011365)2.01065916
108Rhinitis (HP:0012384)2.00804035
109Generalized tonic-clonic seizures (HP:0002069)2.00684706
110Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99210459
111Fair hair (HP:0002286)1.98929015
112Severe muscular hypotonia (HP:0006829)1.98707103
113Renal cortical cysts (HP:0000803)1.98575052
114Aplasia involving bones of the upper limbs (HP:0009823)1.98391809
115Aplasia of the phalanges of the hand (HP:0009802)1.98391809
116Aplasia involving bones of the extremities (HP:0009825)1.98391809
117Hemiparesis (HP:0001269)1.98031978
118Anencephaly (HP:0002323)1.96229403
119Prostate neoplasm (HP:0100787)1.94843929
120Anomalous pulmonary venous return (HP:0010772)1.93775005
121Steppage gait (HP:0003376)1.93601048
122Abnormally folded helix (HP:0008544)1.93313294
123Hypoplasia of the uterus (HP:0000013)1.92550112
124Bile duct proliferation (HP:0001408)1.92030378
125Abnormal biliary tract physiology (HP:0012439)1.92030378
126Hypoplastic pelvis (HP:0008839)1.91801352
127Progressive macrocephaly (HP:0004481)1.91553121
128Epileptic encephalopathy (HP:0200134)1.90341126
129Methylmalonic acidemia (HP:0002912)1.90040113
130Osteomalacia (HP:0002749)1.89111555
131Cerebral inclusion bodies (HP:0100314)1.88983319
132Keratoconus (HP:0000563)1.88897411
133Increased corneal curvature (HP:0100692)1.88897411
134Mixed hearing impairment (HP:0000410)1.87423238
135Abnormal mitochondria in muscle tissue (HP:0008316)1.87171988
136Double outlet right ventricle (HP:0001719)1.86510422
137Congenital malformation of the right heart (HP:0011723)1.86510422
138Excessive salivation (HP:0003781)1.85459499
139Drooling (HP:0002307)1.85459499
140Abnormal sex determination (HP:0012244)1.84717203
141Sex reversal (HP:0012245)1.84717203
142Neoplasm of the adrenal cortex (HP:0100641)1.84588198
143Retinal dysplasia (HP:0007973)1.84143550
144Hypomagnesemia (HP:0002917)1.83700107
145Postaxial foot polydactyly (HP:0001830)1.83440333
146Optic nerve hypoplasia (HP:0000609)1.82656700
147Gaze-evoked nystagmus (HP:0000640)1.82269904
148Optic disc pallor (HP:0000543)1.81219750
149Asplenia (HP:0001746)1.81098555
150Delayed CNS myelination (HP:0002188)1.80582891
151Lactic acidosis (HP:0003128)1.79602777
152Methylmalonic aciduria (HP:0012120)1.79004733
153Hypoplasia of the iris (HP:0007676)1.78656497
154Absent thumb (HP:0009777)1.78556440
155Attenuation of retinal blood vessels (HP:0007843)1.78487323
156Genital tract atresia (HP:0001827)1.78237320
157Adrenal hypoplasia (HP:0000835)1.78016115
158Abnormality of the renal medulla (HP:0100957)1.77973715
159Abnormality of the ileum (HP:0001549)1.77878961
160Congenital hepatic fibrosis (HP:0002612)1.77653368
161Short tibia (HP:0005736)1.77487806
162Submucous cleft hard palate (HP:0000176)1.77446352
163Ulnar claw (HP:0001178)1.77123847
164Myelomeningocele (HP:0002475)1.76551584
165Vaginal atresia (HP:0000148)1.75834825
166Abnormality of binocular vision (HP:0011514)1.75420463
167Diplopia (HP:0000651)1.75420463
168Congenital ichthyosiform erythroderma (HP:0007431)1.74695008
169Thickened helices (HP:0000391)1.73901629
170Conical tooth (HP:0000698)1.73122095
171Meckel diverticulum (HP:0002245)1.73054255
172Male pseudohermaphroditism (HP:0000037)1.72423609
173Abnormality of the pulmonary veins (HP:0011718)1.72108656
174Dialeptic seizures (HP:0011146)1.71539942
175Bony spicule pigmentary retinopathy (HP:0007737)1.71310577
176Tachypnea (HP:0002789)1.70652145
177Preaxial hand polydactyly (HP:0001177)1.70322734
178Partial duplication of thumb phalanx (HP:0009944)1.69910515
179Hypoalbuminemia (HP:0003073)1.69722339
180Abnormal albumin level (HP:0012116)1.69722339
181Renal Fanconi syndrome (HP:0001994)1.68331227
182Microretrognathia (HP:0000308)1.67817440
183Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66136404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.06418845
2CASK4.23769079
3TNIK3.86402582
4ZAK3.47568782
5STK392.96009493
6PNCK2.88177386
7STK162.76653111
8GRK12.75644153
9BLK2.50412771
10ACVR1B2.38756799
11OXSR12.31176651
12NTRK32.29674250
13PKN12.28574138
14MAP4K22.23769788
15MST1R2.21271777
16EIF2AK31.93596017
17NUAK11.87513765
18EPHA41.83147445
19FGR1.76051856
20TXK1.70344861
21NEK61.67797502
22MAP3K121.62908553
23TAOK31.60946522
24GRK71.60903666
25FES1.57905462
26MAPK151.57001632
27MAPK131.53744436
28INSRR1.53464902
29TRIM281.53295564
30ADRBK21.46692609
31NTRK21.45638873
32MARK11.43537769
33BMPR1B1.42886749
34STK38L1.41554447
35BRSK21.40849358
36EPHB11.33083219
37ERBB31.32558143
38BCR1.28663402
39IRAK21.27452703
40SIK21.26829643
41PINK11.24640532
42MAP3K131.24096886
43EPHA21.23353322
44WNK41.20558207
45UHMK11.16851418
46EIF2AK21.15755434
47CAMK1G1.13004273
48BUB11.11920703
49MAPKAPK51.07410815
50MAP2K71.06557121
51MUSK1.03970143
52PRKCE1.03284129
53CAMK2B1.02383988
54TSSK61.01985082
55WNK11.01852353
56RIPK41.01498245
57CAMK2A1.01178922
58WEE10.98485601
59MAP3K40.97109404
60VRK10.97035703
61PLK30.96843513
62PRKCI0.96304487
63MKNK20.94245130
64PBK0.91791984
65CDK30.90388686
66PTK2B0.89873688
67CSNK1A1L0.88225855
68PIK3CA0.87951085
69STK30.87908763
70IRAK10.87319729
71ROCK20.87064861
72NME10.85174680
73TGFBR10.82286837
74YES10.81755813
75MARK20.81342300
76CAMK2D0.81279104
77FGFR20.81030620
78DYRK20.80645781
79TNK20.80061573
80CDK190.79167784
81NEK10.79153099
82NTRK10.78680782
83CHEK20.78297158
84CLK10.77175957
85PRKCQ0.76640390
86ITK0.73325662
87MAP3K90.72749123
88EPHB20.72582127
89GRK50.72504240
90CAMKK20.72447624
91BCKDK0.71267380
92NEK20.71130510
93IKBKB0.70569560
94CSNK1G30.70526916
95STK110.70429117
96CDC70.68320854
97CSNK1G10.67276507
98PLK40.66814756
99PLK10.64938009
100CDK50.64732329
101PRKG10.64611558
102MST40.63574294
103PHKG20.60121575
104PHKG10.60121575
105ADRBK10.58948099
106DAPK20.57441219
107FLT30.56577726
108BMPR20.56197695
109RPS6KA50.56121179
110SGK10.55400590
111CSNK1A10.54944631
112CAMK2G0.54896829
113PRKAA20.54835020
114DYRK1A0.54594126
115PRKD20.54087096
116PRKACA0.53897608
117FYN0.53782236
118PAK60.53678135
119PAK30.53442906
120ICK0.53354230
121BRD40.52937014
122PRKCG0.52852151
123MAPKAPK30.52732066
124CSNK1G20.50972820
125ERBB40.49190625
126EIF2AK10.48899802
127VRK20.48767258
128ATR0.47648521
129MKNK10.45893039
130TLK10.44906046
131PLK20.44639335
132FER0.43267527
133MAP2K60.41853180
134WNK30.41366024
135CHUK0.41021426
136AURKB0.40260753
137TYRO30.39480747
138SGK2230.39362194
139SGK4940.39362194
140MET0.38904566
141SRPK10.38844956
142CAMK10.38475725
143PRPF4B0.38078421
144CSNK1E0.37701966
145CSNK1D0.37621039
146DMPK0.37300350
147PRKCB0.36652799
148OBSCN0.35950738
149TTK0.34641462
150ATM0.34185498
151DAPK10.32296573
152TAF10.31707690
153MAP3K140.31095048
154FGFR10.30841350
155IGF1R0.29513212
156CSNK2A10.27895433

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.70116342
2Phototransduction_Homo sapiens_hsa047443.07869054
3Protein export_Homo sapiens_hsa030602.68737273
4RNA polymerase_Homo sapiens_hsa030202.52573255
5Homologous recombination_Homo sapiens_hsa034402.40637626
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.33274496
7Selenocompound metabolism_Homo sapiens_hsa004502.33071886
8Basal transcription factors_Homo sapiens_hsa030222.27643459
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25586310
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23944420
11Oxidative phosphorylation_Homo sapiens_hsa001902.19047139
12Serotonergic synapse_Homo sapiens_hsa047262.16559986
13Taste transduction_Homo sapiens_hsa047422.16186157
14Glutamatergic synapse_Homo sapiens_hsa047242.12913326
15Ether lipid metabolism_Homo sapiens_hsa005652.09395221
16Proteasome_Homo sapiens_hsa030502.08370923
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06105039
18Morphine addiction_Homo sapiens_hsa050322.02938561
19Fatty acid elongation_Homo sapiens_hsa000622.01751051
20Caffeine metabolism_Homo sapiens_hsa002321.96955482
21One carbon pool by folate_Homo sapiens_hsa006701.95028392
22Axon guidance_Homo sapiens_hsa043601.93479520
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88493023
24RNA degradation_Homo sapiens_hsa030181.83534110
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83254203
26GABAergic synapse_Homo sapiens_hsa047271.82661000
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.80759545
28Sphingolipid metabolism_Homo sapiens_hsa006001.79419758
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78848853
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.70001127
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64854813
32Nitrogen metabolism_Homo sapiens_hsa009101.62641736
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.56367373
34Tryptophan metabolism_Homo sapiens_hsa003801.52083275
35Alzheimers disease_Homo sapiens_hsa050101.50556311
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49936153
37Salivary secretion_Homo sapiens_hsa049701.49880234
38Collecting duct acid secretion_Homo sapiens_hsa049661.49831182
39Steroid biosynthesis_Homo sapiens_hsa001001.47352281
40Long-term depression_Homo sapiens_hsa047301.46365841
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43907282
42Calcium signaling pathway_Homo sapiens_hsa040201.42510868
43Amphetamine addiction_Homo sapiens_hsa050311.41939288
44Propanoate metabolism_Homo sapiens_hsa006401.39247709
45Cardiac muscle contraction_Homo sapiens_hsa042601.37150731
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36832964
47Pyrimidine metabolism_Homo sapiens_hsa002401.34747020
48Renin secretion_Homo sapiens_hsa049241.33016141
49Cocaine addiction_Homo sapiens_hsa050301.31467403
50Circadian entrainment_Homo sapiens_hsa047131.26393572
51Parkinsons disease_Homo sapiens_hsa050121.24281821
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22630487
53Gastric acid secretion_Homo sapiens_hsa049711.22249317
54Ribosome_Homo sapiens_hsa030101.21349406
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19409673
56Linoleic acid metabolism_Homo sapiens_hsa005911.19358303
57Dopaminergic synapse_Homo sapiens_hsa047281.15450532
58Nucleotide excision repair_Homo sapiens_hsa034201.12501656
59Purine metabolism_Homo sapiens_hsa002301.05201116
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.04167382
61Mismatch repair_Homo sapiens_hsa034301.03834512
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00936204
63Oxytocin signaling pathway_Homo sapiens_hsa049211.00844168
64Olfactory transduction_Homo sapiens_hsa047401.00631286
65RNA transport_Homo sapiens_hsa030130.99918938
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.99728453
67Type I diabetes mellitus_Homo sapiens_hsa049400.99221495
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98633636
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98026922
70Ovarian steroidogenesis_Homo sapiens_hsa049130.97124871
71Fatty acid biosynthesis_Homo sapiens_hsa000610.96937917
72Cholinergic synapse_Homo sapiens_hsa047250.96861638
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96379794
74Peroxisome_Homo sapiens_hsa041460.96324557
75Regulation of autophagy_Homo sapiens_hsa041400.96098121
76Huntingtons disease_Homo sapiens_hsa050160.95789652
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94822592
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.93169648
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92084715
80Long-term potentiation_Homo sapiens_hsa047200.89153839
81cAMP signaling pathway_Homo sapiens_hsa040240.86979756
82Allograft rejection_Homo sapiens_hsa053300.86504854
83Hedgehog signaling pathway_Homo sapiens_hsa043400.86208333
84Base excision repair_Homo sapiens_hsa034100.85921873
85Dorso-ventral axis formation_Homo sapiens_hsa043200.85744691
86Rheumatoid arthritis_Homo sapiens_hsa053230.84276775
87Arachidonic acid metabolism_Homo sapiens_hsa005900.83493921
88Autoimmune thyroid disease_Homo sapiens_hsa053200.83299499
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83120027
90Insulin secretion_Homo sapiens_hsa049110.82882473
91Ras signaling pathway_Homo sapiens_hsa040140.82267316
92Chemical carcinogenesis_Homo sapiens_hsa052040.82110277
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81868648
94Pancreatic secretion_Homo sapiens_hsa049720.80086895
95beta-Alanine metabolism_Homo sapiens_hsa004100.76853715
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76693909
97Synaptic vesicle cycle_Homo sapiens_hsa047210.76572895
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75057902
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73761040
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.73342034
101Wnt signaling pathway_Homo sapiens_hsa043100.73171380
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71749698
103Histidine metabolism_Homo sapiens_hsa003400.70601999
104Metabolic pathways_Homo sapiens_hsa011000.70519551
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.69798314
106Non-homologous end-joining_Homo sapiens_hsa034500.69262902
107Choline metabolism in cancer_Homo sapiens_hsa052310.69128368
108Melanogenesis_Homo sapiens_hsa049160.68807753
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68461872
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67789978
111GnRH signaling pathway_Homo sapiens_hsa049120.66441807
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65615608
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.65304886
114Retinol metabolism_Homo sapiens_hsa008300.65119283
115Fanconi anemia pathway_Homo sapiens_hsa034600.64664510
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62798080
117Circadian rhythm_Homo sapiens_hsa047100.62667150
118Basal cell carcinoma_Homo sapiens_hsa052170.61249457
119ErbB signaling pathway_Homo sapiens_hsa040120.60401482
120Butanoate metabolism_Homo sapiens_hsa006500.59676674
121Dilated cardiomyopathy_Homo sapiens_hsa054140.59219242
122MAPK signaling pathway_Homo sapiens_hsa040100.58074847
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58044848
124Gap junction_Homo sapiens_hsa045400.56902627
125Primary immunodeficiency_Homo sapiens_hsa053400.56817312
126African trypanosomiasis_Homo sapiens_hsa051430.56543137
127p53 signaling pathway_Homo sapiens_hsa041150.56354069
128Glycerolipid metabolism_Homo sapiens_hsa005610.56275491
129ECM-receptor interaction_Homo sapiens_hsa045120.56234386
130Spliceosome_Homo sapiens_hsa030400.55310400
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54114520
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53513807
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53235763
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51772313
135Antigen processing and presentation_Homo sapiens_hsa046120.51413961
136Mineral absorption_Homo sapiens_hsa049780.50226800
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.50199565
138ABC transporters_Homo sapiens_hsa020100.49181440
139Vibrio cholerae infection_Homo sapiens_hsa051100.49059447
140DNA replication_Homo sapiens_hsa030300.48452653
141Asthma_Homo sapiens_hsa053100.48236664
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.47545966
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46500167
144Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45375898
145Melanoma_Homo sapiens_hsa052180.45345827
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43357507
147Arginine and proline metabolism_Homo sapiens_hsa003300.42858201
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42364260
149Pyruvate metabolism_Homo sapiens_hsa006200.40332488
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39278770
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38997394
152Sulfur metabolism_Homo sapiens_hsa009200.37878308
153Vitamin B6 metabolism_Homo sapiens_hsa007500.37363281
154Protein digestion and absorption_Homo sapiens_hsa049740.36551057
155Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36219576
156Graft-versus-host disease_Homo sapiens_hsa053320.36140640
157Vitamin digestion and absorption_Homo sapiens_hsa049770.35960017
158Renal cell carcinoma_Homo sapiens_hsa052110.35476335
159Hematopoietic cell lineage_Homo sapiens_hsa046400.34125344

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