AP2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.32829909
2locomotory exploration behavior (GO:0035641)5.49842733
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43222018
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26694640
5sodium ion export (GO:0071436)4.83373148
6layer formation in cerebral cortex (GO:0021819)4.80725598
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.67528578
8glutamate secretion (GO:0014047)4.50129682
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.42314267
10synaptic vesicle exocytosis (GO:0016079)4.22527894
11regulation of synaptic vesicle exocytosis (GO:2000300)4.19678958
12regulation of synapse structural plasticity (GO:0051823)4.05751287
13cellular potassium ion homeostasis (GO:0030007)4.00594952
14cytoskeletal anchoring at plasma membrane (GO:0007016)3.98996786
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.98862332
16vocalization behavior (GO:0071625)3.98324845
17activation of protein kinase A activity (GO:0034199)3.94102363
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92502188
19cell communication by electrical coupling (GO:0010644)3.89788574
20exploration behavior (GO:0035640)3.80366149
21protein localization to endosome (GO:0036010)3.78592685
22regulation of glutamate receptor signaling pathway (GO:1900449)3.75509319
23neurotransmitter secretion (GO:0007269)3.74710920
24regulation of neuronal synaptic plasticity (GO:0048168)3.72717227
25neuromuscular process controlling balance (GO:0050885)3.71584705
26sperm capacitation (GO:0048240)3.70108925
27proline transport (GO:0015824)3.69388146
28positive regulation of synapse maturation (GO:0090129)3.66455522
29regulation of synaptic vesicle transport (GO:1902803)3.63476811
30regulation of ARF protein signal transduction (GO:0032012)3.63234703
31negative regulation of erythrocyte differentiation (GO:0045647)3.61552216
32cerebellar Purkinje cell layer development (GO:0021680)3.61157842
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53304689
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.52192062
35glycine transport (GO:0015816)3.48187609
36dendritic spine morphogenesis (GO:0060997)3.42803439
37adherens junction assembly (GO:0034333)3.37592915
38barbed-end actin filament capping (GO:0051016)3.32234375
39protein retention in ER lumen (GO:0006621)3.31600792
40cell-substrate adherens junction assembly (GO:0007045)3.27866798
41focal adhesion assembly (GO:0048041)3.27866798
42protein localization to synapse (GO:0035418)3.27417275
43chromosome condensation (GO:0030261)3.25436055
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.19097137
45fusion of sperm to egg plasma membrane (GO:0007342)3.19012131
46regulation of ARF GTPase activity (GO:0032312)3.18712066
47positive regulation of fibroblast migration (GO:0010763)3.14558663
48planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13904456
49cell-substrate junction assembly (GO:0007044)3.13548310
50cell migration in hindbrain (GO:0021535)3.13214308
51gamma-aminobutyric acid transport (GO:0015812)3.13097583
52regulation of clathrin-mediated endocytosis (GO:2000369)3.12405185
53neuromuscular process controlling posture (GO:0050884)3.12217157
54establishment of nucleus localization (GO:0040023)3.10531567
55vesicle transport along microtubule (GO:0047496)3.08516220
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.05242937
57negative regulation of microtubule polymerization (GO:0031115)3.03935465
58protein targeting to plasma membrane (GO:0072661)3.02874627
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.02508328
60cell-cell junction maintenance (GO:0045217)3.00740445
61negative regulation of cell size (GO:0045792)3.00274597
62insulin-like growth factor receptor signaling pathway (GO:0048009)2.99864649
63intracellular estrogen receptor signaling pathway (GO:0030520)2.99617229
64basement membrane organization (GO:0071711)2.99055963
65regulation of T-helper 2 cell differentiation (GO:0045628)2.98306399
66negative regulation of organelle assembly (GO:1902116)2.97928863
67potassium ion import (GO:0010107)2.97893461
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97624162
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96917932
70cerebellar Purkinje cell differentiation (GO:0021702)2.96734348
71regulation of NFAT protein import into nucleus (GO:0051532)2.94907397
72mannose metabolic process (GO:0006013)2.94491534
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.94319808
74plasma membrane repair (GO:0001778)2.93595147
75dendrite morphogenesis (GO:0048813)2.93481169
76cortical actin cytoskeleton organization (GO:0030866)2.93240251
77Golgi transport vesicle coating (GO:0048200)2.92529911
78COPI coating of Golgi vesicle (GO:0048205)2.92529911
79sexual reproduction (GO:0019953)2.89683098
80synaptic vesicle endocytosis (GO:0048488)2.88810906
81regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88267439
82regulation of early endosome to late endosome transport (GO:2000641)2.88127968
83membrane depolarization during action potential (GO:0086010)2.87886066
84peptidyl-lysine dimethylation (GO:0018027)2.87816883
85DNA packaging (GO:0006323)2.87470757
86neuronal action potential propagation (GO:0019227)2.86500230
87positive regulation of Rab GTPase activity (GO:0032851)2.85758075
88regulation of Rab GTPase activity (GO:0032313)2.85758075
89cellular sodium ion homeostasis (GO:0006883)2.85179962
90regulation of dendritic spine morphogenesis (GO:0061001)2.81352913
91long-term memory (GO:0007616)2.81065600
92regulation of translational termination (GO:0006449)2.80813594
93axon cargo transport (GO:0008088)2.80593986
94alanine transport (GO:0032328)2.78048528
95clathrin coat assembly (GO:0048268)2.77788344
96organelle transport along microtubule (GO:0072384)2.77297371
97regulation of synaptic plasticity (GO:0048167)2.76238142
98cell communication involved in cardiac conduction (GO:0086065)2.76086983
99semaphorin-plexin signaling pathway (GO:0071526)2.75175980
100neurotransmitter transport (GO:0006836)2.74316911
101positive regulation of receptor recycling (GO:0001921)2.73324368
102potassium ion homeostasis (GO:0055075)2.73115873
103prepulse inhibition (GO:0060134)2.71163494
104acrosome reaction (GO:0007340)2.70751130
105positive regulation of myotube differentiation (GO:0010831)2.70600912
106stress fiber assembly (GO:0043149)2.70023566
107neurotransmitter-gated ion channel clustering (GO:0072578)2.69818401
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69740241
109positive regulation of histone deacetylation (GO:0031065)2.68562601
110synaptic transmission, glutamatergic (GO:0035249)2.68313307
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68068557
112neuromuscular process (GO:0050905)2.67751505
113hyaluronan catabolic process (GO:0030214)2.65861706
114positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65654181
115positive regulation of membrane potential (GO:0045838)2.63868583
116activation of Rac GTPase activity (GO:0032863)2.63707379
117auditory behavior (GO:0031223)2.63622111
118neuronal ion channel clustering (GO:0045161)2.63445717
119signal complex assembly (GO:0007172)2.63326635
120regulation of histone H3-K27 methylation (GO:0061085)2.62696134
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.61270420
122glucose 6-phosphate metabolic process (GO:0051156)2.60847557
123cortical cytoskeleton organization (GO:0030865)2.60226798
124membrane repolarization (GO:0086009)2.58799526
125phosphatidylethanolamine biosynthetic process (GO:0006646)2.58650533
126apoptotic cell clearance (GO:0043277)2.57027948
127regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56492314
128regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54934218
129peptidyl-proline hydroxylation (GO:0019511)2.54729168
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54702726
131positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54516048
132dendritic spine organization (GO:0097061)2.54477017
133response to auditory stimulus (GO:0010996)2.53412434
134regulation of neurotransmitter levels (GO:0001505)2.53060787
135pre-miRNA processing (GO:0031054)2.52605781
136receptor recycling (GO:0001881)2.52409994
137positive regulation of Cdc42 GTPase activity (GO:0043089)2.51740568
138mitotic G1 DNA damage checkpoint (GO:0031571)2.49863511
139dopamine receptor signaling pathway (GO:0007212)2.49775992
140regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49495213
141actin filament capping (GO:0051693)2.46693054
142innervation (GO:0060384)2.45841676
143actin cytoskeleton reorganization (GO:0031532)2.45348020
144negative regulation of fatty acid transport (GO:2000192)2.45090122
145response to acidic pH (GO:0010447)2.44864874
146sperm motility (GO:0030317)2.44089606
147positive regulation of protein dephosphorylation (GO:0035307)2.44024886
148membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43153867
149positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43036540
150regulation of neurotransmitter secretion (GO:0046928)2.42379580
151regulation of postsynaptic membrane potential (GO:0060078)2.41922133
152regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41672095
153cerebellar granule cell differentiation (GO:0021707)2.41351602
154positive regulation of dendritic spine morphogenesis (GO:0061003)2.41257093
155nerve growth factor signaling pathway (GO:0038180)2.41036353
156histone H4 deacetylation (GO:0070933)2.40982745
157regulation of extracellular matrix disassembly (GO:0010715)2.40952066
158negative regulation of actin filament depolymerization (GO:0030835)2.40517861
159plasma membrane fusion (GO:0045026)2.40012246
160membrane protein ectodomain proteolysis (GO:0006509)2.38704142
161apoptotic process involved in morphogenesis (GO:0060561)2.38568157
162skin morphogenesis (GO:0043589)2.38495053
163negative regulation of inclusion body assembly (GO:0090084)2.38320675
164cell volume homeostasis (GO:0006884)2.38022080
165modulation by symbiont of host cellular process (GO:0044068)2.36828773
166cellular response to pH (GO:0071467)2.36035850
167actin filament bundle organization (GO:0061572)2.35405275
168actin filament bundle assembly (GO:0051017)2.35405275
169response to laminar fluid shear stress (GO:0034616)2.34604554
170epithelial cell-cell adhesion (GO:0090136)2.33036329
171tooth mineralization (GO:0034505)2.32729096
172modulation by virus of host process (GO:0019054)2.26115958
173atrioventricular valve morphogenesis (GO:0003181)2.25905777
174vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25723154
175regulation of glucose import in response to insulin stimulus (GO:2001273)2.25330418
176G1 DNA damage checkpoint (GO:0044783)2.22825040
177protein heterotrimerization (GO:0070208)2.22179429
178phosphatidylethanolamine metabolic process (GO:0046337)2.21633160
179mitotic G1/S transition checkpoint (GO:0044819)2.21501778
180hemidesmosome assembly (GO:0031581)2.21432512
181embryonic process involved in female pregnancy (GO:0060136)2.19508982
182protein-DNA complex disassembly (GO:0032986)2.19121427
183nucleosome disassembly (GO:0006337)2.19121427
184modulation by virus of host morphology or physiology (GO:0019048)2.18456498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65223455
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.58356048
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.90237922
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89690957
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87703546
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.69984193
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.68666852
8DROSHA_22980978_ChIP-Seq_HELA_Human2.44594674
9KDM2B_26808549_Chip-Seq_K562_Human2.36530581
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31934653
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.26426666
12KDM2B_26808549_Chip-Seq_DND41_Human2.23814922
13LXR_22292898_ChIP-Seq_THP-1_Human2.20146580
14REST_21632747_ChIP-Seq_MESCs_Mouse2.13563407
15* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.13036976
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.08233199
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03641874
18REST_18959480_ChIP-ChIP_MESCs_Mouse1.99250692
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99006510
20DNAJC2_21179169_ChIP-ChIP_NT2_Human1.94232770
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92503166
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.89749297
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88025513
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84755815
25* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83051025
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81585570
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78707719
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76816528
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76213132
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73338300
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73338300
32GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72931505
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72238865
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71166559
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.66371295
36ZNF263_19887448_ChIP-Seq_K562_Human1.65378759
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64986219
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64975620
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64816468
40MYC_22102868_ChIP-Seq_BL_Human1.63939442
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63212751
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62570166
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62103576
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62058693
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60533896
46TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58619414
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.58496880
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58351566
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57990664
50TCF7_22412390_ChIP-Seq_EML_Mouse1.56483683
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56050881
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52297353
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.50585940
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.48648371
55SMC4_20622854_ChIP-Seq_HELA_Human1.47491299
56CREB1_26743006_Chip-Seq_LNCaP_Human1.45095424
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42739041
58CTCF_27219007_Chip-Seq_Bcells_Human1.40688973
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39595966
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38199992
61VDR_24763502_ChIP-Seq_THP-1_Human1.37046723
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33224026
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.32156242
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.32091981
65* BCOR_27268052_Chip-Seq_Bcells_Human1.32007633
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.31753052
67* P68_20966046_ChIP-Seq_HELA_Human1.31441546
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30465860
69RACK7_27058665_Chip-Seq_MCF-7_Human1.30387098
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30336701
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30141512
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29871406
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28283528
74* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26240191
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.26081123
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24491463
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23741586
78* BCL6_27268052_Chip-Seq_Bcells_Human1.21781233
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.21124631
80ELF1_20517297_ChIP-Seq_JURKAT_Human1.20463950
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20131504
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20032686
83OCT4_19829295_ChIP-Seq_ESCs_Human1.19587179
84NCOR1_26117541_ChIP-Seq_K562_Human1.19075381
85MAF_26560356_Chip-Seq_TH1_Human1.17987009
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17278529
87CLOCK_20551151_ChIP-Seq_293T_Human1.17234828
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17185550
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17100856
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16825461
91* ATF3_27146783_Chip-Seq_COLON_Human1.16622710
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15519678
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.15345346
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15161269
95KLF4_19829295_ChIP-Seq_ESCs_Human1.12617278
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12321095
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12094926
98* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11507309
99GATA1_19941826_ChIP-Seq_K562_Human1.10721592
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09567796
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.07601777
102* SPI1_23127762_ChIP-Seq_K562_Human1.07007837
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06319454
104UBF1/2_26484160_Chip-Seq_HMECs_Human1.06072816
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05707416
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05235647
107MAF_26560356_Chip-Seq_TH2_Human1.05192173
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05167243
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04764746
110* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03626023
111MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03529733
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.03458324
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03219857
114* PHF8_20622854_ChIP-Seq_HELA_Human1.02416881
115UTX_26944678_Chip-Seq_JUKART_Human1.02407257
116* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02394205
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.01965187
118TP53_22127205_ChIP-Seq_IMR90_Human1.01889201
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.01173920
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00767542
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00315760
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00100976
123* AR_19668381_ChIP-Seq_PC3_Human1.00004317
124SA1_27219007_Chip-Seq_Bcells_Human0.99611819
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.99499816
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99305882
127* TP63_22573176_ChIP-Seq_HFKS_Human0.99142426
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97988457
129* E2F1_20622854_ChIP-Seq_HELA_Human0.97490869
130ZNF274_21170338_ChIP-Seq_K562_Hela0.97475706
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97163800
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96478073
133RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96087348
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.95502559
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94945867
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93394535
137SMAD4_21741376_ChIP-Seq_ESCs_Human0.91864099
138GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91555440
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.89702529
140RUNX1_27514584_Chip-Seq_MCF-7_Human0.89203476
141VDR_21846776_ChIP-Seq_THP-1_Human0.89131684
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88030214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.64464761
2MP0008438_abnormal_cutaneous_collagen4.27653952
3MP0003635_abnormal_synaptic_transmissio3.52590332
4MP0005451_abnormal_body_composition3.37616561
5MP0004270_analgesia3.27365565
6MP0003283_abnormal_digestive_organ2.95932602
7MP0004858_abnormal_nervous_system2.95857886
8MP0002063_abnormal_learning/memory/cond2.70605155
9MP0003566_abnormal_cell_adhesion2.67017731
10MP0009780_abnormal_chondrocyte_physiolo2.54437069
11MP0001958_emphysema2.40468840
12MP0002909_abnormal_adrenal_gland2.39403515
13MP0003279_aneurysm2.35061961
14MP0003880_abnormal_central_pattern2.34746328
15MP0002064_seizures2.34523488
16MP0009745_abnormal_behavioral_response2.33484710
17MP0003329_amyloid_beta_deposits2.25615428
18MP0009046_muscle_twitch2.25583485
19MP0008961_abnormal_basal_metabolism2.21878932
20MP0003705_abnormal_hypodermis_morpholog2.18339753
21MP0005423_abnormal_somatic_nervous2.13884269
22MP0002822_catalepsy2.09037858
23MP0005058_abnormal_lysosome_morphology2.06549702
24MP0005623_abnormal_meninges_morphology2.02999214
25MP0004811_abnormal_neuron_physiology2.00817050
26MP0004272_abnormal_basement_membrane1.99655415
27MP0005670_abnormal_white_adipose1.96151060
28MP0008260_abnormal_autophagy1.94670002
29MP0005257_abnormal_intraocular_pressure1.92587336
30MP0002734_abnormal_mechanical_nocicepti1.91554036
31MP0001968_abnormal_touch/_nociception1.89975665
32MP0004233_abnormal_muscle_weight1.89831060
33MP0002572_abnormal_emotion/affect_behav1.88160853
34MP0005377_hearing/vestibular/ear_phenot1.83555228
35MP0003878_abnormal_ear_physiology1.83555228
36MP0008569_lethality_at_weaning1.81754254
37MP0000751_myopathy1.79123360
38MP0000678_abnormal_parathyroid_gland1.78280944
39MP0009278_abnormal_bone_marrow1.74862331
40MP0002733_abnormal_thermal_nociception1.70974675
41MP0002653_abnormal_ependyma_morphology1.70823836
42MP0005275_abnormal_skin_tensile1.68956733
43MP0005409_darkened_coat_color1.66901858
44MP0000955_abnormal_spinal_cord1.66444749
45MP0004885_abnormal_endolymph1.65675306
46MP0002272_abnormal_nervous_system1.64176859
47MP0002249_abnormal_larynx_morphology1.60879865
48MP0009840_abnormal_foam_cell1.58928415
49MP0003191_abnormal_cellular_cholesterol1.56813618
50MP0001486_abnormal_startle_reflex1.52205055
51MP0003879_abnormal_hair_cell1.49740859
52MP0001970_abnormal_pain_threshold1.45331206
53MP0005410_abnormal_fertilization1.43335897
54MP0003172_abnormal_lysosome_physiology1.41303869
55MP0003436_decreased_susceptibility_to1.37441417
56MP0001440_abnormal_grooming_behavior1.36766111
57MP0010234_abnormal_vibrissa_follicle1.36473572
58MP0000013_abnormal_adipose_tissue1.36216855
59MP0002060_abnormal_skin_morphology1.33417886
60MP0003122_maternal_imprinting1.30155363
61MP0000569_abnormal_digit_pigmentation1.29111698
62MP0002184_abnormal_innervation1.28976672
63MP0003633_abnormal_nervous_system1.27954485
64MP0005076_abnormal_cell_differentiation1.26360103
65MP0002735_abnormal_chemical_nociception1.26123330
66MP0001348_abnormal_lacrimal_gland1.25945404
67MP0000747_muscle_weakness1.23363992
68MP0000767_abnormal_smooth_muscle1.21110315
69MP0002736_abnormal_nociception_after1.18148646
70MP0005023_abnormal_wound_healing1.18046694
71MP0000778_abnormal_nervous_system1.17828748
72MP0002882_abnormal_neuron_morphology1.17724169
73MP0005666_abnormal_adipose_tissue1.17715118
74MP0002066_abnormal_motor_capabilities/c1.17493185
75MP0000733_abnormal_muscle_development1.16855001
76MP0003075_altered_response_to1.16727481
77MP0002557_abnormal_social/conspecific_i1.15768759
78MP0002067_abnormal_sensory_capabilities1.15761614
79MP0005503_abnormal_tendon_morphology1.15616344
80MP0002152_abnormal_brain_morphology1.13748630
81MP0001501_abnormal_sleep_pattern1.13380266
82MP0000003_abnormal_adipose_tissue1.12661264
83MP0001849_ear_inflammation1.12548934
84MP0004947_skin_inflammation1.12344701
85MP0005167_abnormal_blood-brain_barrier1.09605487
86MP0002234_abnormal_pharynx_morphology1.08448070
87MP0002269_muscular_atrophy1.08388196
88MP0004145_abnormal_muscle_electrophysio1.07920593
89MP0003453_abnormal_keratinocyte_physiol1.07262473
90MP0004130_abnormal_muscle_cell1.06244649
91MP0005386_behavior/neurological_phenoty1.05749101
92MP0004924_abnormal_behavior1.05749101
93MP0002089_abnormal_postnatal_growth/wei1.05530345
94MP0005083_abnormal_biliary_tract1.04093414
95MP0003787_abnormal_imprinting1.02914944
96MP0003631_nervous_system_phenotype1.02081682
97MP0000604_amyloidosis1.01955746
98MP0002998_abnormal_bone_remodeling0.98393892
99MP0003123_paternal_imprinting0.96788998
100MP0003634_abnormal_glial_cell0.96534846
101MP0009384_cardiac_valve_regurgitation0.95580197
102MP0002896_abnormal_bone_mineralization0.93078973
103MP0010352_gastrointestinal_tract_polyps0.92627940
104MP0009053_abnormal_anal_canal0.92439659
105MP0004087_abnormal_muscle_fiber0.91661192
106MP0001533_abnormal_skeleton_physiology0.90788352
107MP0000534_abnormal_ureter_morphology0.88526207
108MP0003119_abnormal_digestive_system0.86576784
109MP0003303_peritoneal_inflammation0.86535161
110MP0000858_altered_metastatic_potential0.85822105
111MP0008770_decreased_survivor_rate0.85445399
112MP0003300_gastrointestinal_ulcer0.85176398
113MP0004185_abnormal_adipocyte_glucose0.84750190
114MP0001299_abnormal_eye_distance/0.84088330
115MP0002796_impaired_skin_barrier0.83312090
116MP0003861_abnormal_nervous_system0.81346562
117MP0005397_hematopoietic_system_phenotyp0.81231902
118MP0001545_abnormal_hematopoietic_system0.81231902
119MP0002877_abnormal_melanocyte_morpholog0.78793516
120MP0003656_abnormal_erythrocyte_physiolo0.78058781
121MP0003632_abnormal_nervous_system0.77611594
122MP0008874_decreased_physiological_sensi0.77513559
123MP0004085_abnormal_heartbeat0.77440359
124MP0004510_myositis0.77177134
125MP0003045_fibrosis0.77138222
126MP0005390_skeleton_phenotype0.77067221
127MP0001915_intracranial_hemorrhage0.76963578
128MP0000759_abnormal_skeletal_muscle0.75658695
129MP0003690_abnormal_glial_cell0.75324890
130MP0005621_abnormal_cell_physiology0.74925206
131MP0003828_pulmonary_edema0.74899517
132MP0003137_abnormal_impulse_conducting0.74399687
133MP0004084_abnormal_cardiac_muscle0.73977187
134MP0000750_abnormal_muscle_regeneration0.73351439
135MP0005508_abnormal_skeleton_morphology0.73016259
136MP0002069_abnormal_eating/drinking_beha0.72525198
137MP0010630_abnormal_cardiac_muscle0.72069895
138MP0001614_abnormal_blood_vessel0.72061920
139MP0000920_abnormal_myelination0.71449492
140MP0005375_adipose_tissue_phenotype0.71054361
141MP0006138_congestive_heart_failure0.70260806
142MP0005187_abnormal_penis_morphology0.69810605
143MP0001502_abnormal_circadian_rhythm0.69443683
144MP0000681_abnormal_thyroid_gland0.68982112
145MP0002229_neurodegeneration0.68039667
146MP0003115_abnormal_respiratory_system0.67509778
147MP0008872_abnormal_physiological_respon0.67330481
148MP0005595_abnormal_vascular_smooth0.66919781
149MP0000749_muscle_degeneration0.66587814
150MP0003698_abnormal_male_reproductive0.66552985
151MP0005501_abnormal_skin_physiology0.65895966
152MP0003091_abnormal_cell_migration0.65873071
153MP0005645_abnormal_hypothalamus_physiol0.64320456
154MP0000467_abnormal_esophagus_morphology0.63257117
155MP0002837_dystrophic_cardiac_calcinosis0.62533634
156MP0009931_abnormal_skin_appearance0.61052210
157MP0010368_abnormal_lymphatic_system0.60656122
158MP0010769_abnormal_survival0.60099247
159MP0002925_abnormal_cardiovascular_devel0.58685848

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.81253164
2Premature rupture of membranes (HP:0001788)4.30721145
3Abnormality of the lower motor neuron (HP:0002366)4.29693495
4Protrusio acetabuli (HP:0003179)4.19346432
5Visual hallucinations (HP:0002367)3.93784107
6Insomnia (HP:0100785)3.68869007
7Focal seizures (HP:0007359)3.51782804
8Supranuclear gaze palsy (HP:0000605)3.47895784
9Ankle clonus (HP:0011448)3.30177196
10Hyperacusis (HP:0010780)3.28566384
11Focal motor seizures (HP:0011153)3.23618849
12Asymmetric septal hypertrophy (HP:0001670)3.10367575
13Upper limb amyotrophy (HP:0009129)3.10093107
14Distal upper limb amyotrophy (HP:0007149)3.10093107
15Action tremor (HP:0002345)3.00572772
16Depression (HP:0000716)2.98976230
17Increased connective tissue (HP:0009025)2.94838131
18Pointed chin (HP:0000307)2.85605355
19Hand muscle atrophy (HP:0009130)2.81874520
20Distal lower limb amyotrophy (HP:0008944)2.78763575
21Postural instability (HP:0002172)2.72935422
22Broad face (HP:0000283)2.71674116
23Dysmetric saccades (HP:0000641)2.68530827
24Cervical subluxation (HP:0003308)2.64307868
25Impaired vibration sensation in the lower limbs (HP:0002166)2.64003219
26Annular pancreas (HP:0001734)2.63796192
27Peritonitis (HP:0002586)2.62718856
28Atrophic scars (HP:0001075)2.61800068
29Urinary urgency (HP:0000012)2.60671299
30Fragile skin (HP:0001030)2.56250229
31Spinal rigidity (HP:0003306)2.55512643
32Ankle contracture (HP:0006466)2.54947349
33Papilledema (HP:0001085)2.53934025
34Bundle branch block (HP:0011710)2.51685384
35Hemiplegia (HP:0002301)2.51657312
36Urinary bladder sphincter dysfunction (HP:0002839)2.50912141
37Neoplasm of the heart (HP:0100544)2.49984518
38Ulnar bowing (HP:0003031)2.49051654
39Cerebral aneurysm (HP:0004944)2.48554673
40Elfin facies (HP:0004428)2.47415450
41Ventricular fibrillation (HP:0001663)2.47270944
42Increased variability in muscle fiber diameter (HP:0003557)2.47194932
43Disproportionate tall stature (HP:0001519)2.47078074
44Cerebral inclusion bodies (HP:0100314)2.45358150
45Vertebral compression fractures (HP:0002953)2.44418371
46Impaired social interactions (HP:0000735)2.43678121
47Abnormal social behavior (HP:0012433)2.43678121
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43295740
49Poor eye contact (HP:0000817)2.41864822
50Distal lower limb muscle weakness (HP:0009053)2.41798817
51Hypercortisolism (HP:0001578)2.41065073
52Achilles tendon contracture (HP:0001771)2.37555277
53Amyotrophic lateral sclerosis (HP:0007354)2.37535585
54Resting tremor (HP:0002322)2.36250979
55Polycythemia (HP:0001901)2.31185906
56Abnormal gallbladder physiology (HP:0012438)2.29247294
57Cholecystitis (HP:0001082)2.29247294
58Progressive cerebellar ataxia (HP:0002073)2.28143098
59Renal duplication (HP:0000075)2.25631455
60Impaired smooth pursuit (HP:0007772)2.23306844
61Insidious onset (HP:0003587)2.22713625
62Termporal pattern (HP:0011008)2.22713625
63Dysdiadochokinesis (HP:0002075)2.22610870
64Overriding aorta (HP:0002623)2.22475322
65Epileptic encephalopathy (HP:0200134)2.20913601
66Dilatation of the ascending aorta (HP:0005111)2.20185896
67Lower limb amyotrophy (HP:0007210)2.20012793
68Torticollis (HP:0000473)2.19696009
69Rapidly progressive (HP:0003678)2.19240948
70Astrocytoma (HP:0009592)2.19081686
71Abnormality of the astrocytes (HP:0100707)2.19081686
72Renovascular hypertension (HP:0100817)2.18718735
73Generalized tonic-clonic seizures (HP:0002069)2.18011414
74Mutism (HP:0002300)2.16027050
75Wormian bones (HP:0002645)2.15915733
76Macroorchidism (HP:0000053)2.15540569
77Type 1 muscle fiber predominance (HP:0003803)2.15380494
78Vascular tortuosity (HP:0004948)2.15293723
79Ankyloglossia (HP:0010296)2.15015130
80Blue sclerae (HP:0000592)2.14982756
81Aneurysm (HP:0002617)2.14830699
82Bowel diverticulosis (HP:0005222)2.14736792
83Thin bony cortex (HP:0002753)2.13856628
84Megalencephaly (HP:0001355)2.13060235
85Abnormality of skeletal muscle fiber size (HP:0012084)2.12821464
86Genetic anticipation (HP:0003743)2.12506261
87Abnormality of the Achilles tendon (HP:0005109)2.11732323
88Difficulty running (HP:0009046)2.11027493
89Bell-shaped thorax (HP:0001591)2.10511704
90Aortic aneurysm (HP:0004942)2.09992819
91Mildly elevated creatine phosphokinase (HP:0008180)2.08702307
92Hemiparesis (HP:0001269)2.06284693
93Spastic gait (HP:0002064)2.05823737
94Mitral regurgitation (HP:0001653)2.05125568
95Aortic dissection (HP:0002647)2.04902245
96Arterial tortuosity (HP:0005116)2.04592215
97Broad metatarsal (HP:0001783)2.03414331
98Apathy (HP:0000741)2.03357332
99Turricephaly (HP:0000262)2.03188942
100Difficulty climbing stairs (HP:0003551)2.03144729
101Absence seizures (HP:0002121)2.01602751
102Abnormality of ocular smooth pursuit (HP:0000617)2.01587770
103Truncal ataxia (HP:0002078)2.01488052
104Neuronal loss in central nervous system (HP:0002529)1.99112030
105Bradykinesia (HP:0002067)1.98115238
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.97543489
107Slender build (HP:0001533)1.97192056
108Biconcave vertebral bodies (HP:0004586)1.97076496
109Stridor (HP:0010307)1.96561782
110Long palpebral fissure (HP:0000637)1.96034989
111Hyperextensible skin (HP:0000974)1.95654964
112Clonus (HP:0002169)1.94431829
113Cellulitis (HP:0100658)1.94284308
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94170598
115Lower limb muscle weakness (HP:0007340)1.92862852
116Shallow orbits (HP:0000586)1.92553591
117Dysmetria (HP:0001310)1.91645023
118Neurofibrillary tangles (HP:0002185)1.90806611
119Ependymoma (HP:0002888)1.89207975
120Intellectual disability, profound (HP:0002187)1.88756880
121Bladder diverticulum (HP:0000015)1.88037063
122Atonic seizures (HP:0010819)1.87873665
123Heterotopia (HP:0002282)1.87477214
124Focal dystonia (HP:0004373)1.86156412
125Abnormal eating behavior (HP:0100738)1.86154756
126Intention tremor (HP:0002080)1.85994272
127Joint laxity (HP:0001388)1.85863778
128Thin ribs (HP:0000883)1.84524965
129Neonatal short-limb short stature (HP:0008921)1.83898976
130Diminished motivation (HP:0000745)1.82716939
131Abnormality of dentin (HP:0010299)1.82401938
132EMG: neuropathic changes (HP:0003445)1.82204189
133Flat cornea (HP:0007720)1.81521189
134Amblyopia (HP:0000646)1.81274303
135Mitral valve prolapse (HP:0001634)1.80710643
136Short nail (HP:0001799)1.80047339
137Abnormality of binocular vision (HP:0011514)1.78353009
138Diplopia (HP:0000651)1.78353009
139Enlarged penis (HP:0000040)1.78106878
140Anxiety (HP:0000739)1.76555627
141Genu recurvatum (HP:0002816)1.76499759
142Dialeptic seizures (HP:0011146)1.76159111
143Global brain atrophy (HP:0002283)1.73788049
144Hammertoe (HP:0001765)1.73726861
145Cholelithiasis (HP:0001081)1.73334870
146Obstructive sleep apnea (HP:0002870)1.70214601
147Craniofacial dystonia (HP:0012179)1.69760177
148Abnormality of the acetabulum (HP:0003170)1.69147498
149Peripheral hypomyelination (HP:0007182)1.68215030
150Abnormality of oral frenula (HP:0000190)1.67726491
151Slow saccadic eye movements (HP:0000514)1.67667962
152Hypertriglyceridemia (HP:0002155)1.67520502
153Decreased motor nerve conduction velocity (HP:0003431)1.67216141
154Myocardial infarction (HP:0001658)1.66517385
155Ectopia lentis (HP:0001083)1.66002070
156Advanced eruption of teeth (HP:0006288)1.65599601
157Reticulocytosis (HP:0001923)1.65283571
158Arnold-Chiari malformation (HP:0002308)1.65278459
159Soft skin (HP:0000977)1.65065648
160Status epilepticus (HP:0002133)1.64989541
161Hemorrhage of the eye (HP:0011885)1.64584529
162Abnormality of the nasal mucosa (HP:0000433)1.63361809
163Easy fatigability (HP:0003388)1.62211600
164Atelectasis (HP:0100750)1.61576756
165Patellar dislocation (HP:0002999)1.58504889
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.57980610
167Osteolytic defects of the hand bones (HP:0009699)1.57980610
168Bowel incontinence (HP:0002607)1.57572888
169Acanthosis nigricans (HP:0000956)1.57461556
170Elbow flexion contracture (HP:0002987)1.54556881
171Precocious puberty (HP:0000826)1.54468092
172Venous abnormality (HP:0002624)1.53651796
173Metaphyseal cupping (HP:0003021)1.52801261
174Gingivitis (HP:0000230)1.51884251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.71142012
2MAP3K93.68134030
3PRPF4B3.15728822
4TRIB33.15609878
5NTRK32.76739211
6SMG12.64127819
7PAK62.61873737
8KSR22.55733005
9SIK12.37812278
10EPHA42.29638021
11ICK2.25743212
12MINK12.12497941
13PKN22.11840123
14CAMKK12.11801258
15MARK12.06158485
16NTRK11.96846074
17DAPK21.93256916
18TYRO31.89926354
19TAOK11.86472123
20RIPK11.84636900
21EEF2K1.75968884
22LATS21.75769176
23MAP3K41.69778239
24STK381.67544036
25ALK1.66441481
26NEK11.63760300
27SCYL21.56676867
28IRAK31.56067855
29MAP2K31.54410217
30NTRK21.49840432
31PDGFRA1.45074950
32MAP3K101.41081631
33KSR11.37511419
34FGFR41.37279962
35TAOK21.29282906
36LMTK21.28900545
37SIK21.28351869
38UHMK11.27129772
39MAP3K21.26302840
40PLK41.22645893
41RET1.21121669
42TESK11.20532298
43ARAF1.18525905
44CDK51.15344570
45PHKG21.15103743
46PHKG11.15103743
47EPHB11.13934767
48MAP2K41.12281930
49BMX1.12101726
50PRKCH1.09898450
51PRKG21.09060930
52MAP3K31.06362020
53DAPK11.05757923
54DDR21.05104075
55EPHA20.99307376
56MST1R0.96272379
57CDK120.95407522
58CDK150.92265954
59PDK30.91450712
60PDK40.91450712
61MARK20.89820825
62TESK20.89527182
63CDK180.87953766
64MAP3K10.85830704
65STK110.85326439
66CDK140.85318963
67BRAF0.84537070
68CDC42BPA0.84164337
69CAMK1G0.83764770
70CDK11A0.83349678
71PAK30.81519850
72TTN0.78742491
73MAP3K80.77696680
74RPS6KC10.75704059
75RPS6KL10.75704059
76BRSK10.75257332
77MAP3K60.74760789
78PDK10.74616333
79PTK2B0.73843028
80PTK60.73297585
81CDK190.73203553
82MAP3K70.69893543
83MTOR0.68616532
84PTK20.68422570
85PDPK10.68370313
86PRKCG0.67513203
87DMPK0.65850419
88MAPK110.63882172
89WNK10.62092724
90ERN10.60657479
91MOS0.60570044
92ZAP700.60419890
93BRD40.59185600
94JAK30.57989557
95CAMK10.55655486
96DAPK30.55100022
97CDK70.55096519
98MAP2K20.54972628
99SGK30.53465072
100RPS6KA20.52877811
101PAK20.52470140
102MAPK120.52130839
103MET0.51981415
104GRK50.51920444
105RPS6KA60.51751341
106HIPK20.50978438
107GRK60.50360733
108CAMKK20.50026160
109FER0.47903885
110RPS6KA30.47805835
111FES0.47686818
112MAPK100.47594838
113MAP2K10.46652513
114PRKD20.44621147
115RAF10.44440776
116PNCK0.43839409
117ROCK20.43535074
118ROCK10.42813834
119DYRK1B0.41910209
120CAMK40.41153435
121MAP3K110.41152365
122PDGFRB0.41109625
123CAMK1D0.40470385
124PRKD10.39720418
125PRKCZ0.39663088
126RIPK40.36429076
127SGK10.36340468
128BLK0.35887808
129IRAK40.35808000
130PRKAA10.35777239
131PINK10.35687880
132TYK20.34923733
133RPS6KA10.34817461
134MAP2K70.34378404
135PAK40.33871047
136MAP3K130.33795066
137FYN0.33571760
138MAPK80.33192175
139NEK60.31944557
140LIMK10.31391773
141JAK20.31188458
142MAPK70.30999103

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54041513
2* Synaptic vesicle cycle_Homo sapiens_hsa047212.48407460
3* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43540942
4Nitrogen metabolism_Homo sapiens_hsa009102.13002817
5Olfactory transduction_Homo sapiens_hsa047402.12999703
6Long-term potentiation_Homo sapiens_hsa047202.09940453
7Circadian entrainment_Homo sapiens_hsa047131.95483285
8Insulin secretion_Homo sapiens_hsa049111.84565821
9GABAergic synapse_Homo sapiens_hsa047271.80031378
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79235815
11Amphetamine addiction_Homo sapiens_hsa050311.75748056
12Acute myeloid leukemia_Homo sapiens_hsa052211.70529201
13Gastric acid secretion_Homo sapiens_hsa049711.69261928
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69214728
15Nicotine addiction_Homo sapiens_hsa050331.68038345
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68017012
17Glutamatergic synapse_Homo sapiens_hsa047241.67876740
18Dopaminergic synapse_Homo sapiens_hsa047281.65546222
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64865361
20Salivary secretion_Homo sapiens_hsa049701.64272737
21Type II diabetes mellitus_Homo sapiens_hsa049301.55263773
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54688840
23Morphine addiction_Homo sapiens_hsa050321.54131133
24Glioma_Homo sapiens_hsa052141.50954009
25Cholinergic synapse_Homo sapiens_hsa047251.49863636
26Other glycan degradation_Homo sapiens_hsa005111.45406146
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45280334
28Estrogen signaling pathway_Homo sapiens_hsa049151.44094694
29Oxytocin signaling pathway_Homo sapiens_hsa049211.43324390
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43275072
31Gap junction_Homo sapiens_hsa045401.40939264
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38026272
33GnRH signaling pathway_Homo sapiens_hsa049121.36234671
34mTOR signaling pathway_Homo sapiens_hsa041501.34288734
35ECM-receptor interaction_Homo sapiens_hsa045121.31107152
36Cocaine addiction_Homo sapiens_hsa050301.29055660
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.26555597
38Dorso-ventral axis formation_Homo sapiens_hsa043201.24035696
39Renin secretion_Homo sapiens_hsa049241.22066073
40Notch signaling pathway_Homo sapiens_hsa043301.19607720
41B cell receptor signaling pathway_Homo sapiens_hsa046621.19056703
42Pancreatic cancer_Homo sapiens_hsa052121.17318220
43VEGF signaling pathway_Homo sapiens_hsa043701.15916803
44Oocyte meiosis_Homo sapiens_hsa041141.15266837
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.13769432
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.13046682
47Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11217835
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09396884
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08614357
50ErbB signaling pathway_Homo sapiens_hsa040121.07790285
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.06780437
52Long-term depression_Homo sapiens_hsa047301.06586097
53Amoebiasis_Homo sapiens_hsa051461.06295359
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04353280
55cAMP signaling pathway_Homo sapiens_hsa040241.03859871
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02709820
57Calcium signaling pathway_Homo sapiens_hsa040201.01842793
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.01760197
59Melanogenesis_Homo sapiens_hsa049161.01285594
60Dilated cardiomyopathy_Homo sapiens_hsa054141.00935111
61Glucagon signaling pathway_Homo sapiens_hsa049220.99970227
62Pentose phosphate pathway_Homo sapiens_hsa000300.98743130
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96173209
64Endometrial cancer_Homo sapiens_hsa052130.94832910
65Osteoclast differentiation_Homo sapiens_hsa043800.93942911
66Thyroid cancer_Homo sapiens_hsa052160.93873477
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.93271497
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93245552
69Non-small cell lung cancer_Homo sapiens_hsa052230.92392170
70Insulin signaling pathway_Homo sapiens_hsa049100.91865432
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91758841
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88743796
73Axon guidance_Homo sapiens_hsa043600.87022311
74Adherens junction_Homo sapiens_hsa045200.86114190
75* Endocytosis_Homo sapiens_hsa041440.85809660
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85127425
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83804767
78Bile secretion_Homo sapiens_hsa049760.82647030
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82254987
80Thyroid hormone synthesis_Homo sapiens_hsa049180.80689298
81Taste transduction_Homo sapiens_hsa047420.80422747
82Chronic myeloid leukemia_Homo sapiens_hsa052200.80304933
83Fructose and mannose metabolism_Homo sapiens_hsa000510.77111451
84Renal cell carcinoma_Homo sapiens_hsa052110.77033217
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76613629
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.76487412
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75041980
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73935554
89Toxoplasmosis_Homo sapiens_hsa051450.73622733
90MAPK signaling pathway_Homo sapiens_hsa040100.73395202
91Biosynthesis of amino acids_Homo sapiens_hsa012300.73227467
92Prostate cancer_Homo sapiens_hsa052150.73018801
93Small cell lung cancer_Homo sapiens_hsa052220.72987209
94Choline metabolism in cancer_Homo sapiens_hsa052310.71790373
95Bladder cancer_Homo sapiens_hsa052190.71392275
96MicroRNAs in cancer_Homo sapiens_hsa052060.70942357
97Protein digestion and absorption_Homo sapiens_hsa049740.70938044
98Galactose metabolism_Homo sapiens_hsa000520.70331126
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70010230
100Rap1 signaling pathway_Homo sapiens_hsa040150.69278797
101AMPK signaling pathway_Homo sapiens_hsa041520.67924234
102Hepatitis B_Homo sapiens_hsa051610.67341816
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67121430
104Pancreatic secretion_Homo sapiens_hsa049720.66792508
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66583273
106Malaria_Homo sapiens_hsa051440.66507282
107Proteoglycans in cancer_Homo sapiens_hsa052050.65995050
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.64855130
109Prion diseases_Homo sapiens_hsa050200.63612808
110Vibrio cholerae infection_Homo sapiens_hsa051100.63582478
111Colorectal cancer_Homo sapiens_hsa052100.63105199
112Platelet activation_Homo sapiens_hsa046110.62012009
113Insulin resistance_Homo sapiens_hsa049310.60873361
114Fatty acid biosynthesis_Homo sapiens_hsa000610.59790937
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59786944
116Focal adhesion_Homo sapiens_hsa045100.59419536
117Shigellosis_Homo sapiens_hsa051310.59400599
118Hippo signaling pathway_Homo sapiens_hsa043900.59282239
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59154256
120Serotonergic synapse_Homo sapiens_hsa047260.58181256
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58033185
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57191545
123Hepatitis C_Homo sapiens_hsa051600.57102107
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56795645
125Lysosome_Homo sapiens_hsa041420.56326157
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.56311534
127Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55607986
128Chemokine signaling pathway_Homo sapiens_hsa040620.55198346
129Tight junction_Homo sapiens_hsa045300.55193771
130Apoptosis_Homo sapiens_hsa042100.54702145
131Prolactin signaling pathway_Homo sapiens_hsa049170.53710272
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.53218607
133Inositol phosphate metabolism_Homo sapiens_hsa005620.52783088
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.52515513
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50683744
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50143688
137Hedgehog signaling pathway_Homo sapiens_hsa043400.49564681
138HIF-1 signaling pathway_Homo sapiens_hsa040660.49364159

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