AP2B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.97972809
2locomotory exploration behavior (GO:0035641)5.80518421
3layer formation in cerebral cortex (GO:0021819)5.38875165
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38412590
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11385265
6COPI coating of Golgi vesicle (GO:0048205)4.70056709
7Golgi transport vesicle coating (GO:0048200)4.70056709
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.57990497
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.54317232
10glutamate secretion (GO:0014047)4.42325313
11exploration behavior (GO:0035640)4.31690731
12vocalization behavior (GO:0071625)4.31170253
13regulation of synaptic vesicle exocytosis (GO:2000300)4.24218978
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.14851883
15synaptic vesicle exocytosis (GO:0016079)4.13947665
16sodium ion export (GO:0071436)4.11717193
17regulation of synapse structural plasticity (GO:0051823)4.02702082
18proline transport (GO:0015824)4.02476394
19regulation of glutamate receptor signaling pathway (GO:1900449)4.00066396
20dendritic spine morphogenesis (GO:0060997)3.87207852
21nuclear pore complex assembly (GO:0051292)3.78798213
22activation of protein kinase A activity (GO:0034199)3.78715269
23protein localization to synapse (GO:0035418)3.74252638
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73655405
25dendrite morphogenesis (GO:0048813)3.73033832
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70476717
27protein retention in ER lumen (GO:0006621)3.62036749
28neurotransmitter secretion (GO:0007269)3.61415369
29regulation of neuronal synaptic plasticity (GO:0048168)3.59885555
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59599957
31establishment of nucleus localization (GO:0040023)3.59078358
32regulation of synaptic vesicle transport (GO:1902803)3.58496326
33positive regulation of synapse maturation (GO:0090129)3.58163657
34regulation of ARF protein signal transduction (GO:0032012)3.58161153
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.54432619
36cellular potassium ion homeostasis (GO:0030007)3.53891503
37neuromuscular process controlling balance (GO:0050885)3.51661823
38cell migration in hindbrain (GO:0021535)3.44018041
39vesicle transport along microtubule (GO:0047496)3.37610768
40cell communication by electrical coupling (GO:0010644)3.30104119
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29265245
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.28989550
43gamma-aminobutyric acid transport (GO:0015812)3.25917875
44cerebellar Purkinje cell layer development (GO:0021680)3.16575621
45cerebellar granule cell differentiation (GO:0021707)3.15467890
46nuclear pore organization (GO:0006999)3.14443700
47regulation of dendritic spine morphogenesis (GO:0061001)3.12999217
48regulation of nucleobase-containing compound transport (GO:0032239)3.11843973
49adherens junction assembly (GO:0034333)3.10886791
50regulation of clathrin-mediated endocytosis (GO:2000369)3.10860821
51protein localization to endosome (GO:0036010)3.08351145
52regulation of translational fidelity (GO:0006450)3.07048148
53regulation of early endosome to late endosome transport (GO:2000641)3.06728861
54organelle transport along microtubule (GO:0072384)3.05826822
55protein localization to microtubule (GO:0035372)3.04834665
56regulation of RNA export from nucleus (GO:0046831)3.02903846
57paraxial mesoderm development (GO:0048339)2.99473764
58neurotransmitter-gated ion channel clustering (GO:0072578)2.98005492
59DNA unwinding involved in DNA replication (GO:0006268)2.97934861
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96228197
61axonal fasciculation (GO:0007413)2.95016084
62long-term memory (GO:0007616)2.94414557
63innervation (GO:0060384)2.93094124
64neuron cell-cell adhesion (GO:0007158)2.91836077
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91136317
66synaptic transmission, glutamatergic (GO:0035249)2.90879399
67axon cargo transport (GO:0008088)2.90520929
68negative regulation of microtubule polymerization (GO:0031115)2.89604127
69pyrimidine nucleobase catabolic process (GO:0006208)2.89155437
70axon extension (GO:0048675)2.88031267
71focal adhesion assembly (GO:0048041)2.87698781
72cell-substrate adherens junction assembly (GO:0007045)2.87698781
73regulation of ARF GTPase activity (GO:0032312)2.87208599
74nerve growth factor signaling pathway (GO:0038180)2.87007073
75prepulse inhibition (GO:0060134)2.86524049
76neuron recognition (GO:0008038)2.86124482
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84230024
78negative regulation of organelle assembly (GO:1902116)2.83585178
79positive regulation of dendritic spine morphogenesis (GO:0061003)2.83294594
80alanine transport (GO:0032328)2.80820270
81hemidesmosome assembly (GO:0031581)2.80797050
82positive regulation of fibroblast migration (GO:0010763)2.80352294
83regulation of NFAT protein import into nucleus (GO:0051532)2.78933365
84negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78866063
85regulation of synaptic plasticity (GO:0048167)2.78583978
86cell-substrate junction assembly (GO:0007044)2.78401200
87positive regulation of axon extension (GO:0045773)2.78217916
88regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76855363
89dendritic spine organization (GO:0097061)2.76023810
90cerebellar Purkinje cell differentiation (GO:0021702)2.75704643
91membrane depolarization during action potential (GO:0086010)2.74682043
92synaptic vesicle endocytosis (GO:0048488)2.74374553
93activation of Rac GTPase activity (GO:0032863)2.74208556
94central nervous system projection neuron axonogenesis (GO:0021952)2.72159812
95protein targeting to plasma membrane (GO:0072661)2.71123972
96amino acid import (GO:0043090)2.70999052
97cellular sodium ion homeostasis (GO:0006883)2.70963917
98glutamate receptor signaling pathway (GO:0007215)2.70805138
99cell adhesion mediated by integrin (GO:0033627)2.70319919
100regulation of mitotic spindle organization (GO:0060236)2.69965206
101glucocorticoid receptor signaling pathway (GO:0042921)2.69701763
102* vesicle coating (GO:0006901)2.69301158
103* clathrin coat assembly (GO:0048268)2.69262386
104positive regulation of membrane potential (GO:0045838)2.69056561
105glycine transport (GO:0015816)2.68305080
106neuron projection extension (GO:1990138)2.67700123
107auditory behavior (GO:0031223)2.67362506
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67147802
109regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66696691
110pore complex assembly (GO:0046931)2.64636615
111regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.64549662
112positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.64549662
113calcium ion-dependent exocytosis (GO:0017156)2.64314959
114dopamine receptor signaling pathway (GO:0007212)2.63797760
115response to auditory stimulus (GO:0010996)2.63710052
116neurotransmitter transport (GO:0006836)2.61834860
117glial cell proliferation (GO:0014009)2.61278118
118positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.61218344
119apical protein localization (GO:0045176)2.59466651
120semaphorin-plexin signaling pathway (GO:0071526)2.58776628
121neuron-neuron synaptic transmission (GO:0007270)2.58150940
122stress granule assembly (GO:0034063)2.56941602
123positive regulation of synaptic transmission, GABAergic (GO:0032230)2.56431858
124mitotic chromosome condensation (GO:0007076)2.55669498
125nucleobase catabolic process (GO:0046113)2.53422918
126regulation of postsynaptic membrane potential (GO:0060078)2.53188569
127neuromuscular process (GO:0050905)2.53155675
128skin morphogenesis (GO:0043589)2.53109107
129protein export from nucleus (GO:0006611)2.53059732
130positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.52681674
131regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.51818989
132regulation of neurotransmitter secretion (GO:0046928)2.51429294
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51327091
134mitochondrion transport along microtubule (GO:0047497)2.51327091
135cell communication involved in cardiac conduction (GO:0086065)2.49737908
136negative regulation of dendrite morphogenesis (GO:0050774)2.49307978
137social behavior (GO:0035176)2.48550781
138intraspecies interaction between organisms (GO:0051703)2.48550781
139positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.47185899
140regulation of glucose import in response to insulin stimulus (GO:2001273)2.44824227
141establishment of mitochondrion localization (GO:0051654)2.43985384
142mating behavior (GO:0007617)2.43573877
143regulation of calcium ion-dependent exocytosis (GO:0017158)2.42645139
144asymmetric protein localization (GO:0008105)2.42206310
145regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41919338
146camera-type eye morphogenesis (GO:0048593)2.38813104
147epithelial cell-cell adhesion (GO:0090136)2.35520624
148adherens junction organization (GO:0034332)2.30007285
149barbed-end actin filament capping (GO:0051016)2.29524676
150peptidyl-threonine modification (GO:0018210)2.28435600
151cellular response to prostaglandin stimulus (GO:0071379)2.27162141
152cellular protein complex localization (GO:0034629)2.26894169
153potassium ion homeostasis (GO:0055075)2.25960453
154hippo signaling (GO:0035329)2.25668143
155regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.25152938
156establishment or maintenance of apical/basal cell polarity (GO:0035088)2.24895624
157establishment or maintenance of bipolar cell polarity (GO:0061245)2.24895624
158cellular response to catecholamine stimulus (GO:0071870)2.24045368
159cellular response to monoamine stimulus (GO:0071868)2.24045368
160regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.21713596
161nucleosome disassembly (GO:0006337)2.21382203
162protein-DNA complex disassembly (GO:0032986)2.21382203
163negative regulation of catenin import into nucleus (GO:0035414)2.21382183
164neuronal ion channel clustering (GO:0045161)2.21081228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79007439
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.14273238
3E2F7_22180533_ChIP-Seq_HELA_Human2.98675180
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.86860308
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.70178974
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.68100396
7CLOCK_20551151_ChIP-Seq_293T_Human2.64170450
8DROSHA_22980978_ChIP-Seq_HELA_Human2.57131364
9* RARB_27405468_Chip-Seq_BRAIN_Mouse2.56768841
10REST_21632747_ChIP-Seq_MESCs_Mouse2.31425113
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13220981
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.02860925
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02696939
14* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99711991
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.99684908
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99181508
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99075133
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96564357
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92882344
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92882344
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92522107
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90252402
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89251076
24AR_21909140_ChIP-Seq_LNCAP_Human1.88480625
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.88429467
26KDM2B_26808549_Chip-Seq_K562_Human1.86988026
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84228469
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.81138933
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80515284
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75397293
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73674880
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.73381641
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.72782585
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72769568
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.72007197
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71908364
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71376724
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.70690728
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70239562
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68864584
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.68781030
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64692085
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64125137
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62918726
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61479916
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60883725
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60577853
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60244736
49ZNF274_21170338_ChIP-Seq_K562_Hela1.60169961
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59403909
51RACK7_27058665_Chip-Seq_MCF-7_Human1.57309413
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.56169929
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55655260
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54229106
55KDM2B_26808549_Chip-Seq_DND41_Human1.53272013
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52648117
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52434768
58GBX2_23144817_ChIP-Seq_PC3_Human1.52244805
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.51947143
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49197297
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48870283
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48607808
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46999721
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45367995
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45344757
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43693082
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43192789
68MYC_22102868_ChIP-Seq_BL_Human1.42992372
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41560082
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.39498887
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39251253
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38681873
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37998530
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37720561
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37622674
76HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36855852
77NANOG_21062744_ChIP-ChIP_HESCs_Human1.35915553
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34374230
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33883773
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32873491
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29793063
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.29513117
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28482818
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28411473
85* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24932424
86ZNF263_19887448_ChIP-Seq_K562_Human1.24688551
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23500776
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.22939272
89AR_21572438_ChIP-Seq_LNCaP_Human1.22182224
90* AR_19668381_ChIP-Seq_PC3_Human1.22013843
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17936438
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17785324
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17775325
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17378855
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16288261
96* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16211475
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15867317
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.14702160
99LXR_22292898_ChIP-Seq_THP-1_Human1.13446715
100* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12520818
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11650928
102AHR_22903824_ChIP-Seq_MCF-7_Human1.11635173
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10973665
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.09982740
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09972836
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09407764
107* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08776878
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.08686806
109* ATF3_27146783_Chip-Seq_COLON_Human1.07232528
110CHD1_26751641_Chip-Seq_LNCaP_Human1.06971236
111SMAD3_21741376_ChIP-Seq_ESCs_Human1.05535543
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05315482
113MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05168877
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04632988
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04391056
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04185142
117* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04037623
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.02933264
119* SMAD4_21799915_ChIP-Seq_A2780_Human1.02674582
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01902276
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01854865
122HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01054696
123TCF7_22412390_ChIP-Seq_EML_Mouse1.00955624
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00363592
125ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00160477
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99910167
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.99824744
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99766385
129* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99398915
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98943142
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98619713
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98570929
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98395255
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97824262
135TP53_22127205_ChIP-Seq_IMR90_Human0.97005285
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96754214
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95956665
138SMC4_20622854_ChIP-Seq_HELA_Human0.95432538
139CREB1_26743006_Chip-Seq_LNCaP_Human0.94860650
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.93519921
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93426483
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93426483
143* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92669803
144* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91238389
145KLF4_19829295_ChIP-Seq_ESCs_Human0.90534210
146* STAT3_23295773_ChIP-Seq_U87_Human0.89608403
147CTCF_27219007_Chip-Seq_Bcells_Human0.86822363
148EGR1_19374776_ChIP-ChIP_THP-1_Human0.86312478
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.86062594
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84641520
151OCT4_19829295_ChIP-Seq_ESCs_Human0.84306672
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81971440
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81911207
154* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81811800
155TP53_16413492_ChIP-PET_HCT116_Human0.81579475
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.81329720
157AR_25329375_ChIP-Seq_VCAP_Human0.80981830
158ISL1_27105846_Chip-Seq_CPCs_Mouse0.80478390
159ESR2_21235772_ChIP-Seq_MCF-7_Human0.80432918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.00829025
2MP0004270_analgesia3.79947885
3MP0003635_abnormal_synaptic_transmissio3.76509805
4MP0000569_abnormal_digit_pigmentation3.09603306
5MP0002063_abnormal_learning/memory/cond3.05330013
6MP0009780_abnormal_chondrocyte_physiolo2.87139907
7MP0004858_abnormal_nervous_system2.83353298
8MP0003566_abnormal_cell_adhesion2.52598981
9MP0009745_abnormal_behavioral_response2.52256407
10MP0005423_abnormal_somatic_nervous2.39676593
11MP0003880_abnormal_central_pattern2.36173621
12MP0009046_muscle_twitch2.35065510
13MP0002064_seizures2.34561373
14MP0002734_abnormal_mechanical_nocicepti2.29808897
15MP0003329_amyloid_beta_deposits2.28458494
16MP0010234_abnormal_vibrissa_follicle2.27792291
17MP0001968_abnormal_touch/_nociception2.25124198
18MP0005409_darkened_coat_color2.25088550
19MP0005410_abnormal_fertilization2.23046350
20MP0004811_abnormal_neuron_physiology2.19825570
21MP0002909_abnormal_adrenal_gland2.17661833
22MP0002572_abnormal_emotion/affect_behav2.11195735
23MP0008438_abnormal_cutaneous_collagen2.10108075
24MP0004272_abnormal_basement_membrane2.04137855
25MP0005623_abnormal_meninges_morphology2.03841163
26MP0000778_abnormal_nervous_system1.93784664
27MP0002733_abnormal_thermal_nociception1.90560987
28MP0004885_abnormal_endolymph1.81598129
29MP0008961_abnormal_basal_metabolism1.78270542
30MP0002735_abnormal_chemical_nociception1.78261907
31MP0003705_abnormal_hypodermis_morpholog1.74628756
32MP0005257_abnormal_intraocular_pressure1.70754713
33MP0000955_abnormal_spinal_cord1.70097277
34MP0001486_abnormal_startle_reflex1.68414742
35MP0002184_abnormal_innervation1.67004876
36MP0008569_lethality_at_weaning1.64941155
37MP0003283_abnormal_digestive_organ1.61064108
38MP0001440_abnormal_grooming_behavior1.56389746
39MP0000579_abnormal_nail_morphology1.55394002
40MP0001970_abnormal_pain_threshold1.54616727
41MP0005076_abnormal_cell_differentiation1.53091122
42MP0002822_catalepsy1.51546532
43MP0002736_abnormal_nociception_after1.50985989
44MP0000566_synostosis1.49592280
45MP0003303_peritoneal_inflammation1.48098786
46MP0004233_abnormal_muscle_weight1.47342602
47MP0002272_abnormal_nervous_system1.46294339
48MP0003787_abnormal_imprinting1.43058482
49MP0001730_embryonic_growth_arrest1.41761572
50MP0002557_abnormal_social/conspecific_i1.40943038
51MP0001348_abnormal_lacrimal_gland1.37964317
52MP0003385_abnormal_body_wall1.37141288
53MP0002882_abnormal_neuron_morphology1.30496941
54MP0002067_abnormal_sensory_capabilities1.30139805
55MP0009672_abnormal_birth_weight1.30042144
56MP0002152_abnormal_brain_morphology1.29729895
57MP0003633_abnormal_nervous_system1.28098566
58MP0005386_behavior/neurological_phenoty1.27983265
59MP0004924_abnormal_behavior1.27983265
60MP0000604_amyloidosis1.26301045
61MP0004185_abnormal_adipocyte_glucose1.24379197
62MP0001501_abnormal_sleep_pattern1.23034482
63MP0000537_abnormal_urethra_morphology1.22836775
64MP0003300_gastrointestinal_ulcer1.21646080
65MP0003172_abnormal_lysosome_physiology1.21433665
66MP0000762_abnormal_tongue_morphology1.21322626
67MP0005187_abnormal_penis_morphology1.20748596
68MP0001346_abnormal_lacrimal_gland1.19430941
69MP0003879_abnormal_hair_cell1.19272858
70MP0002066_abnormal_motor_capabilities/c1.18547855
71MP0000428_abnormal_craniofacial_morphol1.13990421
72MP0002653_abnormal_ependyma_morphology1.13592532
73MP0002084_abnormal_developmental_patter1.13089337
74MP0003942_abnormal_urinary_system1.12639764
75MP0003631_nervous_system_phenotype1.09953098
76MP0001299_abnormal_eye_distance/1.07487610
77MP0010352_gastrointestinal_tract_polyps1.07117089
78MP0005380_embryogenesis_phenotype1.04678683
79MP0001672_abnormal_embryogenesis/_devel1.04678683
80MP0000350_abnormal_cell_proliferation1.03968118
81MP0001915_intracranial_hemorrhage1.01694063
82MP0003111_abnormal_nucleus_morphology1.00923957
83MP0002080_prenatal_lethality1.00898099
84MP0008932_abnormal_embryonic_tissue1.00865993
85MP0004130_abnormal_muscle_cell1.00393247
86MP0003634_abnormal_glial_cell0.99807610
87MP0003984_embryonic_growth_retardation0.99669459
88MP0002085_abnormal_embryonic_tissue0.99308815
89MP0003861_abnormal_nervous_system0.99070882
90MP0005621_abnormal_cell_physiology0.99043786
91MP0002086_abnormal_extraembryonic_tissu0.98062792
92MP0003075_altered_response_to0.97852232
93MP0000534_abnormal_ureter_morphology0.97222414
94MP0002697_abnormal_eye_size0.96586733
95MP0003698_abnormal_male_reproductive0.96367384
96MP0003632_abnormal_nervous_system0.96320303
97MP0000462_abnormal_digestive_system0.96103341
98MP0003045_fibrosis0.94303733
99MP0002089_abnormal_postnatal_growth/wei0.94157501
100MP0009053_abnormal_anal_canal0.93427688
101MP0002088_abnormal_embryonic_growth/wei0.92428336
102MP0000747_muscle_weakness0.92358603
103MP0003941_abnormal_skin_development0.92328529
104MP0004197_abnormal_fetal_growth/weight/0.92258063
105MP0001849_ear_inflammation0.92208751
106MP0002060_abnormal_skin_morphology0.91884885
107MP0001177_atelectasis0.91743170
108MP0010030_abnormal_orbit_morphology0.90694602
109MP0000013_abnormal_adipose_tissue0.90373387
110MP0003091_abnormal_cell_migration0.90025899
111MP0002009_preneoplasia0.89398542
112MP0004957_abnormal_blastocyst_morpholog0.89117085
113MP0003453_abnormal_keratinocyte_physiol0.88194091
114MP0005451_abnormal_body_composition0.87320189
115MP0010630_abnormal_cardiac_muscle0.86946376
116MP0000751_myopathy0.86682406
117MP0003935_abnormal_craniofacial_develop0.85806088
118MP0005167_abnormal_blood-brain_barrier0.85013435
119MP0000678_abnormal_parathyroid_gland0.84773274
120MP0002249_abnormal_larynx_morphology0.83833872
121MP0003122_maternal_imprinting0.83678690
122MP0001697_abnormal_embryo_size0.81590425
123MP0001958_emphysema0.81191196
124MP0004087_abnormal_muscle_fiber0.81190387
125MP0004264_abnormal_extraembryonic_tissu0.80644033
126MP0009703_decreased_birth_body0.78572317
127MP0000759_abnormal_skeletal_muscle0.78133339
128MP0003119_abnormal_digestive_system0.76687199
129MP0002234_abnormal_pharynx_morphology0.75571153
130MP0000467_abnormal_esophagus_morphology0.75270586
131MP0008260_abnormal_autophagy0.74954856
132MP0003690_abnormal_glial_cell0.74890485
133MP0002069_abnormal_eating/drinking_beha0.74340123
134MP0003115_abnormal_respiratory_system0.73545275
135MP0004510_myositis0.72719782
136MP0002090_abnormal_vision0.70686055
137MP0008770_decreased_survivor_rate0.70600435
138MP0001984_abnormal_olfaction0.68675360
139MP0008874_decreased_physiological_sensi0.64718527
140MP0005248_abnormal_Harderian_gland0.63196559
141MP0001502_abnormal_circadian_rhythm0.62409661
142MP0003123_paternal_imprinting0.60983328
143MP0002229_neurodegeneration0.60480086
144MP0002896_abnormal_bone_mineralization0.60361733
145MP0002877_abnormal_melanocyte_morpholog0.57713197
146MP0002161_abnormal_fertility/fecundity0.57495217
147MP0001943_abnormal_respiration0.56028329
148MP0002081_perinatal_lethality0.55948823
149MP0010769_abnormal_survival0.55648062
150MP0000003_abnormal_adipose_tissue0.55492891
151MP0004085_abnormal_heartbeat0.54050314
152MP0000733_abnormal_muscle_development0.51389771

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.60139324
2Abnormality of the lower motor neuron (HP:0002366)3.88351991
3Visual hallucinations (HP:0002367)3.64937558
4Focal seizures (HP:0007359)3.50994044
5Supranuclear gaze palsy (HP:0000605)3.47264321
6Papilledema (HP:0001085)3.41651401
7Amyotrophic lateral sclerosis (HP:0007354)3.33893849
8Focal motor seizures (HP:0011153)3.20125750
9Protrusio acetabuli (HP:0003179)3.14465455
10Action tremor (HP:0002345)3.11653956
11Mutism (HP:0002300)3.11354563
12Premature rupture of membranes (HP:0001788)2.99177179
13Ankle clonus (HP:0011448)2.95482831
14Hyperacusis (HP:0010780)2.90560164
15Cerebral inclusion bodies (HP:0100314)2.82705905
16Impaired vibration sensation in the lower limbs (HP:0002166)2.82396297
17Insidious onset (HP:0003587)2.79774937
18Termporal pattern (HP:0011008)2.79774937
19Insomnia (HP:0100785)2.79118911
20Progressive cerebellar ataxia (HP:0002073)2.78571830
21Urinary bladder sphincter dysfunction (HP:0002839)2.77753064
22Urinary urgency (HP:0000012)2.71690385
23Arterial tortuosity (HP:0005116)2.67297629
24Pointed chin (HP:0000307)2.64408510
25Depression (HP:0000716)2.54143703
26Cortical dysplasia (HP:0002539)2.53653714
27Epileptic encephalopathy (HP:0200134)2.52838617
28Macroorchidism (HP:0000053)2.52536347
29Genetic anticipation (HP:0003743)2.51973605
30Distal lower limb amyotrophy (HP:0008944)2.48748249
31Vascular tortuosity (HP:0004948)2.46182619
32Postural instability (HP:0002172)2.45460404
33Hammertoe (HP:0001765)2.43758841
34Apathy (HP:0000741)2.41022707
35Neurofibrillary tangles (HP:0002185)2.40123770
36Elfin facies (HP:0004428)2.39870646
37Impaired smooth pursuit (HP:0007772)2.36366751
38Poor eye contact (HP:0000817)2.33805296
39Abnormal social behavior (HP:0012433)2.33178137
40Impaired social interactions (HP:0000735)2.33178137
41Inappropriate behavior (HP:0000719)2.32707734
42Dysmetric saccades (HP:0000641)2.31141738
43Megalencephaly (HP:0001355)2.29837933
44Atrophic scars (HP:0001075)2.27722465
45Abnormality of ocular smooth pursuit (HP:0000617)2.25320929
46Hand muscle atrophy (HP:0009130)2.25133866
47Upper limb amyotrophy (HP:0009129)2.24872384
48Distal upper limb amyotrophy (HP:0007149)2.24872384
49Hemiplegia (HP:0002301)2.22346011
50Abnormality of the corticospinal tract (HP:0002492)2.21757257
51Broad face (HP:0000283)2.20875276
52Heterotopia (HP:0002282)2.19926153
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19188073
54Ankyloglossia (HP:0010296)2.17385070
55Renovascular hypertension (HP:0100817)2.16499549
56Vertebral arch anomaly (HP:0008438)2.16451697
57Back pain (HP:0003418)2.16397380
58Diminished motivation (HP:0000745)2.15555089
59Ulnar bowing (HP:0003031)2.13066890
60Subacute progressive viral hepatitis (HP:0006572)2.12898000
61Shallow orbits (HP:0000586)2.12098937
62Truncal ataxia (HP:0002078)2.10947511
63Drooling (HP:0002307)2.10641034
64Excessive salivation (HP:0003781)2.10641034
65Long palpebral fissure (HP:0000637)2.09682947
66Bladder diverticulum (HP:0000015)2.07829186
67Spastic gait (HP:0002064)2.07517961
68Torticollis (HP:0000473)2.06302803
69Dysdiadochokinesis (HP:0002075)2.06052394
70Intellectual disability, profound (HP:0002187)2.04508593
71Absence seizures (HP:0002121)2.03998448
72Intention tremor (HP:0002080)2.03850381
73Diplopia (HP:0000651)2.01090732
74Abnormality of binocular vision (HP:0011514)2.01090732
75Aqueductal stenosis (HP:0002410)2.00904188
76Lower limb amyotrophy (HP:0007210)2.00553678
77Fragile skin (HP:0001030)2.00510979
78Enlarged penis (HP:0000040)2.00241941
79Increased nuchal translucency (HP:0010880)1.99891605
80Neuronal loss in central nervous system (HP:0002529)1.99549980
81Overriding aorta (HP:0002623)1.98154710
82Hemiparesis (HP:0001269)1.98150778
83Disinhibition (HP:0000734)1.96976708
84Abnormality of the astrocytes (HP:0100707)1.96456718
85Astrocytoma (HP:0009592)1.96456718
86Disproportionate tall stature (HP:0001519)1.95678182
87Generalized tonic-clonic seizures (HP:0002069)1.95131751
88Lower limb muscle weakness (HP:0007340)1.95010014
89Turricephaly (HP:0000262)1.94921373
90Atonic seizures (HP:0010819)1.94187501
91Decreased motor nerve conduction velocity (HP:0003431)1.93708751
92Renal duplication (HP:0000075)1.93082812
93Arnold-Chiari malformation (HP:0002308)1.92808027
94Resting tremor (HP:0002322)1.92790832
95Wormian bones (HP:0002645)1.92285844
96Abnormal eating behavior (HP:0100738)1.92101637
97Aplasia involving bones of the upper limbs (HP:0009823)1.90328710
98Aplasia of the phalanges of the hand (HP:0009802)1.90328710
99Aplasia involving bones of the extremities (HP:0009825)1.90328710
100Annular pancreas (HP:0001734)1.90275104
101Bowel diverticulosis (HP:0005222)1.90226179
102Spinal rigidity (HP:0003306)1.90170635
103Cerebral aneurysm (HP:0004944)1.89972698
104Bundle branch block (HP:0011710)1.89396633
105Mitral regurgitation (HP:0001653)1.87648304
106Relative macrocephaly (HP:0004482)1.86693660
107Absent/shortened dynein arms (HP:0200106)1.85387733
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.85387733
109Stereotypic behavior (HP:0000733)1.85378028
110Distal sensory impairment (HP:0002936)1.84741138
111Dysmetria (HP:0001310)1.84700375
112Neoplasm of the heart (HP:0100544)1.84207045
113Cholecystitis (HP:0001082)1.82815996
114Abnormal gallbladder physiology (HP:0012438)1.82815996
115Patellar dislocation (HP:0002999)1.82262051
116Obstructive sleep apnea (HP:0002870)1.82231141
117Abnormality of oral frenula (HP:0000190)1.81623833
118Rapidly progressive (HP:0003678)1.81412646
119Asymmetry of the thorax (HP:0001555)1.80719681
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.80469256
121Gaze-evoked nystagmus (HP:0000640)1.80289982
122Bradykinesia (HP:0002067)1.79957784
123Buphthalmos (HP:0000557)1.79363661
124Flat acetabular roof (HP:0003180)1.78929926
125Broad-based gait (HP:0002136)1.78336581
126Sacral dimple (HP:0000960)1.77821421
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.77411795
128Missing ribs (HP:0000921)1.76657875
129Bowel incontinence (HP:0002607)1.76258858
130Hypercortisolism (HP:0001578)1.76241326
131Reticulocytosis (HP:0001923)1.75724022
132Focal dystonia (HP:0004373)1.73909107
133Abnormality of the calcaneus (HP:0008364)1.73425386
134Ventricular fibrillation (HP:0001663)1.72478155
135Impaired vibratory sensation (HP:0002495)1.72068036
136Amblyopia (HP:0000646)1.72004712
137Agitation (HP:0000713)1.71936696
138Peripheral hypomyelination (HP:0007182)1.71531521
139Dialeptic seizures (HP:0011146)1.71221974
140Clonus (HP:0002169)1.70502949
141Bronchomalacia (HP:0002780)1.70468736
142Scanning speech (HP:0002168)1.70408013
143Absent frontal sinuses (HP:0002688)1.69572276
144Increased connective tissue (HP:0009025)1.69305180
145Abnormality of pain sensation (HP:0010832)1.67264405
146Impaired pain sensation (HP:0007328)1.67264405
147Trigonocephaly (HP:0000243)1.64902857
148Achilles tendon contracture (HP:0001771)1.64753432
149Deviation of the thumb (HP:0009603)1.63825645
150Mitral valve prolapse (HP:0001634)1.63283357
151Short nail (HP:0001799)1.62934560
152Abnormality of dentin (HP:0010299)1.62813887
153Overgrowth (HP:0001548)1.62479903
154Ankle contracture (HP:0006466)1.61873631
155Precocious puberty (HP:0000826)1.61452922
156Vertebral compression fractures (HP:0002953)1.60357924
157Flat cornea (HP:0007720)1.60320738
158Abnormal large intestine physiology (HP:0012700)1.58963061
159Cubitus valgus (HP:0002967)1.57779707
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.56805126
161Osteolytic defects of the hand bones (HP:0009699)1.56805126
162Foot dorsiflexor weakness (HP:0009027)1.56063547
163Hyperextensible skin (HP:0000974)1.55767461
164Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.54241882
165Advanced eruption of teeth (HP:0006288)1.53253971
166High anterior hairline (HP:0009890)1.52695891
167Hyperparathyroidism (HP:0000843)1.51858334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.42272957
2MAP3K94.03866307
3PRKD33.17513719
4NTRK32.93740336
5KSR22.43376060
6MINK12.36256704
7PAK62.35989139
8TRIB32.27930476
9EPHA42.17998290
10MAP3K42.15516636
11DAPK22.09595504
12CAMKK12.08309022
13SMG12.03913609
14MST1R1.91197199
15PRPF4B1.89250904
16LATS21.88015491
17NTRK21.83326680
18SCYL21.81857681
19RIPK11.76734213
20NTRK11.74041857
21MET1.72603726
22PKN21.72098054
23ICK1.68059316
24TYRO31.67394386
25EPHA21.65884212
26KSR11.64867095
27MAP3K21.63722306
28TESK11.62540312
29PDK31.57717319
30PDK41.57717319
31STK381.48847171
32ALK1.48402491
33RET1.44319130
34TAOK11.42651095
35EEF2K1.41441419
36SIK11.37076186
37SIK21.31292334
38CDK51.25153676
39LMTK21.24420145
40EPHB11.23954781
41EIF2AK11.23782418
42LATS11.22570638
43FGFR41.17697176
44MAP2K41.17585662
45PAK41.16426994
46PDGFRA1.14301441
47PHKG11.13230479
48PHKG21.13230479
49NEK11.10375241
50CAMK1G1.07001829
51BRD41.01367380
52MAP2K70.97775740
53PRKCH0.96475612
54DAPK10.93568586
55PNCK0.91236274
56EPHB20.90559807
57STK110.88447167
58CDK150.88339626
59ARAF0.87805550
60TSSK60.85618997
61CDK180.85294261
62PAK30.85220495
63CDK140.85108499
64MARK20.83267193
65BMX0.83242073
66PDK10.81316736
67PTK2B0.80967018
68PLK20.79310128
69TTK0.78620061
70ERBB40.78505459
71PRKCG0.76555244
72ERBB30.76196306
73DDR20.75289896
74BCR0.75274194
75CDK11A0.74874141
76PTK60.74211757
77ROCK20.71300892
78SGK30.70546478
79MOS0.66883949
80MAP3K60.66344720
81CSNK1G20.66151119
82UHMK10.65986559
83MAP3K100.65582816
84MAPK130.65463176
85RPS6KA20.63818823
86RIPK40.62680361
87PDK20.62348116
88CASK0.61966089
89IRAK30.61011288
90PDPK10.60888255
91FGFR20.59347007
92FER0.58682153
93PRKCZ0.57711618
94GRK50.57026888
95CDK60.56974568
96MAP3K80.55501801
97PDGFRB0.54996342
98CLK10.53779248
99PTK20.53511277
100FYN0.53494275
101CDC42BPA0.53380698
102MTOR0.52157459
103CAMK2B0.50462161
104BRAF0.49689892
105CAMK1D0.48975343
106CDK120.48575366
107DMPK0.48559305
108CAMKK20.47879747
109MAP3K70.47121189
110MAP3K130.46642903
111LIMK10.46005662
112FES0.45897953
113NEK60.45530522
114SGK10.44833081
115RPS6KA30.44376964
116MAP3K10.44135160
117MAP2K10.42568926
118FGFR10.42549536
119RAF10.40901776
120CDK90.40621016
121CAMK10.39872813
122BRSK10.39067427
123PAK20.38961633
124MAPK100.38846128
125AKT20.38822025
126SIK30.38484836
127WNK10.37218507
128CDK70.36450359
129SGK2230.35894613
130SGK4940.35894613
131TTN0.34878301
132MAPK80.34752930
133DYRK1A0.34732087
134FGFR30.34610774
135YES10.31594910
136NEK20.31116710
137CDK10.30371479
138CHEK10.30359174
139EPHA30.30006044

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28325311
2* Synaptic vesicle cycle_Homo sapiens_hsa047212.25904216
3Long-term potentiation_Homo sapiens_hsa047202.19732876
4* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13572991
5Circadian entrainment_Homo sapiens_hsa047132.03050739
6Olfactory transduction_Homo sapiens_hsa047402.02598695
7Nicotine addiction_Homo sapiens_hsa050331.93031168
8GABAergic synapse_Homo sapiens_hsa047271.78648736
9Glutamatergic synapse_Homo sapiens_hsa047241.78043590
10Amphetamine addiction_Homo sapiens_hsa050311.75151797
11Dopaminergic synapse_Homo sapiens_hsa047281.72588913
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.69182433
13Salivary secretion_Homo sapiens_hsa049701.64019792
14Morphine addiction_Homo sapiens_hsa050321.63868595
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62287575
16Gastric acid secretion_Homo sapiens_hsa049711.61829577
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59873818
18Cholinergic synapse_Homo sapiens_hsa047251.58783449
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56595510
20Thyroid cancer_Homo sapiens_hsa052161.56570962
21Glioma_Homo sapiens_hsa052141.55856043
22Insulin secretion_Homo sapiens_hsa049111.55788475
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53016737
24Type II diabetes mellitus_Homo sapiens_hsa049301.49399693
25Estrogen signaling pathway_Homo sapiens_hsa049151.49300519
26Oxytocin signaling pathway_Homo sapiens_hsa049211.39037655
27Renin secretion_Homo sapiens_hsa049241.38764431
28Dorso-ventral axis formation_Homo sapiens_hsa043201.38625842
29Gap junction_Homo sapiens_hsa045401.31607275
30Nitrogen metabolism_Homo sapiens_hsa009101.31304752
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30602381
32mTOR signaling pathway_Homo sapiens_hsa041501.29600426
33GnRH signaling pathway_Homo sapiens_hsa049121.29009185
34Axon guidance_Homo sapiens_hsa043601.23227973
35Endometrial cancer_Homo sapiens_hsa052131.23100848
36Long-term depression_Homo sapiens_hsa047301.22333536
37Cocaine addiction_Homo sapiens_hsa050301.19337540
38Biosynthesis of amino acids_Homo sapiens_hsa012301.16322493
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16219523
40ErbB signaling pathway_Homo sapiens_hsa040121.16088068
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.15963534
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14006992
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13508908
44Oocyte meiosis_Homo sapiens_hsa041141.12816265
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12626597
46ECM-receptor interaction_Homo sapiens_hsa045121.12178202
47VEGF signaling pathway_Homo sapiens_hsa043701.10537598
48MicroRNAs in cancer_Homo sapiens_hsa052061.10174800
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08533681
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07528919
51Vibrio cholerae infection_Homo sapiens_hsa051101.06711320
52Melanogenesis_Homo sapiens_hsa049161.04868167
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03542478
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02111043
55cAMP signaling pathway_Homo sapiens_hsa040241.01607663
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00890759
57Notch signaling pathway_Homo sapiens_hsa043300.99980652
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99794908
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98928834
60mRNA surveillance pathway_Homo sapiens_hsa030150.97566417
61Bladder cancer_Homo sapiens_hsa052190.96010253
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.95667003
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94403867
64Non-small cell lung cancer_Homo sapiens_hsa052230.93333779
65Calcium signaling pathway_Homo sapiens_hsa040200.92923057
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92396981
67Small cell lung cancer_Homo sapiens_hsa052220.91957891
68Colorectal cancer_Homo sapiens_hsa052100.90955648
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.90074177
70Pentose phosphate pathway_Homo sapiens_hsa000300.89125143
71Taste transduction_Homo sapiens_hsa047420.88608430
72Renal cell carcinoma_Homo sapiens_hsa052110.88314654
73Thyroid hormone synthesis_Homo sapiens_hsa049180.87386040
74Vitamin B6 metabolism_Homo sapiens_hsa007500.87244441
75Glucagon signaling pathway_Homo sapiens_hsa049220.87014352
76* Endocytosis_Homo sapiens_hsa041440.82583180
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82260632
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81898461
79Prostate cancer_Homo sapiens_hsa052150.80681987
80Chronic myeloid leukemia_Homo sapiens_hsa052200.80371836
81Insulin signaling pathway_Homo sapiens_hsa049100.78991149
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77974032
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77483236
84Choline metabolism in cancer_Homo sapiens_hsa052310.76896516
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76615233
86Serotonergic synapse_Homo sapiens_hsa047260.76457580
87MAPK signaling pathway_Homo sapiens_hsa040100.75270813
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74855802
89Rap1 signaling pathway_Homo sapiens_hsa040150.74678198
90Cell cycle_Homo sapiens_hsa041100.74103858
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73598165
92Acute myeloid leukemia_Homo sapiens_hsa052210.73333251
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72834542
94Dilated cardiomyopathy_Homo sapiens_hsa054140.72260671
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69919367
96Carbon metabolism_Homo sapiens_hsa012000.69572696
97Proteoglycans in cancer_Homo sapiens_hsa052050.68773120
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.67553830
99Bile secretion_Homo sapiens_hsa049760.67420292
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66655477
101Shigellosis_Homo sapiens_hsa051310.66032789
102Hippo signaling pathway_Homo sapiens_hsa043900.64838994
103Prolactin signaling pathway_Homo sapiens_hsa049170.64795458
104Focal adhesion_Homo sapiens_hsa045100.63620804
105Pathways in cancer_Homo sapiens_hsa052000.62982778
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.62478826
107Pancreatic secretion_Homo sapiens_hsa049720.62472979
108HIF-1 signaling pathway_Homo sapiens_hsa040660.61618286
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.60350966
110Melanoma_Homo sapiens_hsa052180.59652778
111Pancreatic cancer_Homo sapiens_hsa052120.59059799
112AMPK signaling pathway_Homo sapiens_hsa041520.58699841
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58546084
114Fatty acid biosynthesis_Homo sapiens_hsa000610.58183529
115Adherens junction_Homo sapiens_hsa045200.58066267
116Tight junction_Homo sapiens_hsa045300.57902925
117Ras signaling pathway_Homo sapiens_hsa040140.56276776
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56218602
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56147259
120Wnt signaling pathway_Homo sapiens_hsa043100.55703296
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54489241
122Alcoholism_Homo sapiens_hsa050340.54152348
123Prion diseases_Homo sapiens_hsa050200.53216064
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52949462
125Platelet activation_Homo sapiens_hsa046110.52756801
126Inositol phosphate metabolism_Homo sapiens_hsa005620.52577159
127Insulin resistance_Homo sapiens_hsa049310.51573595
128Chemokine signaling pathway_Homo sapiens_hsa040620.51517513
129Amoebiasis_Homo sapiens_hsa051460.51020142

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