AP2S1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.09404322
2DNA deamination (GO:0045006)5.07191839
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.90504613
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49171179
5sequestering of actin monomers (GO:0042989)4.32070933
6ATP synthesis coupled proton transport (GO:0015986)4.16267162
7energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16267162
8viral transcription (GO:0019083)4.15393956
9barbed-end actin filament capping (GO:0051016)4.08696244
10translational termination (GO:0006415)3.98047557
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96942213
12chaperone-mediated protein transport (GO:0072321)3.94315492
13translational elongation (GO:0006414)3.91461701
14regulation of protein heterodimerization activity (GO:0043497)3.84480728
152-deoxyribonucleotide biosynthetic process (GO:0009265)3.73488432
16deoxyribose phosphate biosynthetic process (GO:0046385)3.73488432
17negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.73197743
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.67592147
19respiratory electron transport chain (GO:0022904)3.65840937
20protein targeting to mitochondrion (GO:0006626)3.65474436
21pentose-phosphate shunt (GO:0006098)3.62569288
22formation of translation preinitiation complex (GO:0001731)3.56295278
23nucleobase-containing small molecule interconversion (GO:0015949)3.55040986
24protein targeting to ER (GO:0045047)3.54541740
25electron transport chain (GO:0022900)3.53910599
26cotranslational protein targeting to membrane (GO:0006613)3.49882893
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.49599094
28regulation of early endosome to late endosome transport (GO:2000641)3.49495242
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48213521
30antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.46680200
31purine-containing compound salvage (GO:0043101)3.46400075
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.46206271
33actin nucleation (GO:0045010)3.45087521
34nuclear envelope reassembly (GO:0031468)3.44355499
35mitotic nuclear envelope reassembly (GO:0007084)3.44355499
36viral life cycle (GO:0019058)3.42248847
37establishment of protein localization to mitochondrion (GO:0072655)3.41263131
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41126929
39protein localization to endoplasmic reticulum (GO:0070972)3.39184902
40protein neddylation (GO:0045116)3.37418017
41guanosine-containing compound biosynthetic process (GO:1901070)3.34522915
42galactose catabolic process (GO:0019388)3.32690482
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30522538
44establishment of viral latency (GO:0019043)3.29101589
45cellular protein complex disassembly (GO:0043624)3.27087576
46translational initiation (GO:0006413)3.26306656
47proteasome assembly (GO:0043248)3.25269442
48T cell apoptotic process (GO:0070231)3.25005432
49nucleoside salvage (GO:0043174)3.19625544
50purine nucleotide salvage (GO:0032261)3.19289132
51negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.16625170
52protein localization to mitochondrion (GO:0070585)3.16584500
53NADPH regeneration (GO:0006740)3.15746286
54regulation of cellular amino acid metabolic process (GO:0006521)3.14126493
55regulation of mitochondrial translation (GO:0070129)3.13875516
56establishment of integrated proviral latency (GO:0075713)3.13630404
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10917774
58negative regulation of ligase activity (GO:0051352)3.10917774
59GTP biosynthetic process (GO:0006183)3.09994216
60ribonucleoprotein complex biogenesis (GO:0022613)3.09887878
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08875002
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06847849
63nucleoside diphosphate biosynthetic process (GO:0009133)3.04269467
64UV protection (GO:0009650)3.03958525
65positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.03768251
66nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.01796332
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00406236
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.00227372
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99539503
70protein insertion into membrane (GO:0051205)2.99030012
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97342433
72deoxyribonucleotide biosynthetic process (GO:0009263)2.96797894
73UTP biosynthetic process (GO:0006228)2.95999484
74protein complex biogenesis (GO:0070271)2.95137405
75maturation of SSU-rRNA (GO:0030490)2.93363401
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93226156
77endosome to pigment granule transport (GO:0043485)2.91479659
78endosome to melanosome transport (GO:0035646)2.91479659
79positive regulation of lamellipodium assembly (GO:0010592)2.90390532
80cellular component biogenesis (GO:0044085)2.89812953
81protein complex disassembly (GO:0043241)2.89724545
82response to interferon-beta (GO:0035456)2.88022637
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87097604
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87077722
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87077722
86protein maturation by protein folding (GO:0022417)2.86950117
87negative regulation of microtubule polymerization (GO:0031115)2.86382814
88deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.85928577
89deoxyribonucleotide catabolic process (GO:0009264)2.84843137
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84674069
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84674069
92pentose metabolic process (GO:0019321)2.84521369
93protein retention in ER lumen (GO:0006621)2.84298553
94deoxyribose phosphate catabolic process (GO:0046386)2.83914085
95regulation of mitochondrial membrane potential (GO:0051881)2.82677395
96termination of RNA polymerase III transcription (GO:0006386)2.81397858
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.81397858
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81102767
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81102767
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81102767
101heme biosynthetic process (GO:0006783)2.80713326
102ribosomal small subunit biogenesis (GO:0042274)2.80497154
103macromolecular complex disassembly (GO:0032984)2.80248353
104COPI coating of Golgi vesicle (GO:0048205)2.80223129
105Golgi transport vesicle coating (GO:0048200)2.80223129
106translation (GO:0006412)2.79051319
107regulation of translational termination (GO:0006449)2.78876674
108DNA strand elongation involved in DNA replication (GO:0006271)2.77892532
109pinocytosis (GO:0006907)2.75583062
110negative regulation of mitochondrion organization (GO:0010823)2.74966447
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.74225679
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74225679
113cellular response to zinc ion (GO:0071294)2.73989377
114lymphocyte apoptotic process (GO:0070227)2.73885369
115lipopolysaccharide biosynthetic process (GO:0009103)2.73216774
116purine deoxyribonucleotide catabolic process (GO:0009155)2.72582133
117mitochondrial respiratory chain complex assembly (GO:0033108)2.72370996
118regulation of metalloenzyme activity (GO:0048552)2.70017297
119oxidative phosphorylation (GO:0006119)2.69447664
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69222931
121GDP-mannose metabolic process (GO:0019673)2.68106992
122signal transduction involved in cell cycle checkpoint (GO:0072395)2.66092077
123NADH dehydrogenase complex assembly (GO:0010257)2.65971083
124de novo protein folding (GO:0006458)2.63914851
125de novo posttranslational protein folding (GO:0051084)2.63642800
126nucleotide salvage (GO:0043173)2.63247656
127pyrimidine nucleoside salvage (GO:0043097)2.63096149
128pyrimidine-containing compound salvage (GO:0008655)2.63096149
129positive regulation of ligase activity (GO:0051351)2.61106462
130antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59286287
131DNA strand elongation (GO:0022616)2.56994655
132protein targeting to membrane (GO:0006612)2.55974936
133negative regulation of cell size (GO:0045792)2.55127059
134maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54228998
135deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.53743734
136immunoglobulin mediated immune response (GO:0016064)2.52949256
137* antigen processing and presentation of exogenous peptide antigen (GO:0002478)2.49897739
138* antigen processing and presentation of exogenous antigen (GO:0019884)2.49367591
139ribosomal large subunit biogenesis (GO:0042273)2.48711865
140telomere maintenance via semi-conservative replication (GO:0032201)2.48036126
141metallo-sulfur cluster assembly (GO:0031163)2.47185405
142iron-sulfur cluster assembly (GO:0016226)2.47185405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.43468443
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74298599
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.63165270
4E2F7_22180533_ChIP-Seq_HELA_Human2.41807666
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28609975
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.24571930
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19926434
8VDR_21846776_ChIP-Seq_THP-1_Human2.16282940
9MYC_22102868_ChIP-Seq_BL_Human2.13732260
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.11270692
11XRN2_22483619_ChIP-Seq_HELA_Human2.05639197
12* GABP_17652178_ChIP-ChIP_JURKAT_Human1.96223657
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91267317
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90379704
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89172129
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.88824167
17SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85868743
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85304138
19LXR_22292898_ChIP-Seq_THP-1_Human1.83895812
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83094421
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76795757
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75757602
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74254829
24* ELK3_25401928_ChIP-Seq_HUVEC_Human1.67536573
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.67473858
26* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66110182
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65846329
28* EST1_17652178_ChIP-ChIP_JURKAT_Human1.64620112
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64555093
30GABP_19822575_ChIP-Seq_HepG2_Human1.63022923
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62037098
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61627406
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.61309274
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57536289
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56155785
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55789714
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.52889509
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49837452
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47658874
40BCL6_27268052_Chip-Seq_Bcells_Human1.46981061
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45623224
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44004321
43* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43999389
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43972695
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43322509
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.42963010
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.40274905
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40068025
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.40041511
50CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39589871
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39074165
52VDR_23849224_ChIP-Seq_CD4+_Human1.37519564
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36297525
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36016544
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34730733
56* DCP1A_22483619_ChIP-Seq_HELA_Human1.33709837
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.33667625
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33617044
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33189022
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32328964
61SPI1_23547873_ChIP-Seq_NB4_Human1.32033839
62* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31640215
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30586088
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.29986622
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29689343
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27042282
67BCOR_27268052_Chip-Seq_Bcells_Human1.27036928
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26479301
69MAF_26560356_Chip-Seq_TH1_Human1.24905404
70VDR_24763502_ChIP-Seq_THP-1_Human1.24368008
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23215306
72* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23048692
73P68_20966046_ChIP-Seq_HELA_Human1.22935215
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.22445711
75MAF_26560356_Chip-Seq_TH2_Human1.22241716
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20684175
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20503601
78CIITA_25753668_ChIP-Seq_RAJI_Human1.20002652
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18764404
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18452891
81ZNF263_19887448_ChIP-Seq_K562_Human1.17439544
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17187882
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16500471
84* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16404032
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16385200
86* RUNX1_22412390_ChIP-Seq_EML_Mouse1.15962347
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15469658
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.15289783
89IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14490624
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14222667
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13800364
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13622144
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.13460120
94RACK7_27058665_Chip-Seq_MCF-7_Human1.12891388
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11915768
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11630071
97TFEB_21752829_ChIP-Seq_HELA_Human1.11367476
98UTX_26944678_Chip-Seq_JUKART_Human1.11034052
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10870154
100* TTF2_22483619_ChIP-Seq_HELA_Human1.10618058
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10306186
102OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10253786
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09925946
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09449036
105FOXM1_23109430_ChIP-Seq_U2OS_Human1.09404105
106ATF3_27146783_Chip-Seq_COLON_Human1.09310054
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09122476
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08766191
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.08589310
110FOXP1_21924763_ChIP-Seq_HESCs_Human1.08373268
111TCF7_22412390_ChIP-Seq_EML_Mouse1.08370608
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.08351374
113* FOXP3_21729870_ChIP-Seq_TREG_Human1.07905102
114TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07389810
115* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07177822
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06598080
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06576703
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06204286
119PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05329705
120MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04900623
121HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04696766
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03738812
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00894765
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99469096
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98712665
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98214411
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95169075
128CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94952225
129* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94468478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.03261552
2MP0003436_decreased_susceptibility_to2.92678132
3MP0009379_abnormal_foot_pigmentation2.88126607
4MP0005257_abnormal_intraocular_pressure2.87315472
5MP0002877_abnormal_melanocyte_morpholog2.86215866
6MP0003693_abnormal_embryo_hatching2.76160231
7MP0003303_peritoneal_inflammation2.74993485
8MP0003656_abnormal_erythrocyte_physiolo2.68077138
9MP0005058_abnormal_lysosome_morphology2.66078631
10MP0008438_abnormal_cutaneous_collagen2.61292727
11MP0001835_abnormal_antigen_presentation2.59669390
12MP0008260_abnormal_autophagy2.46444976
13MP0003186_abnormal_redox_activity2.36172538
14MP0004858_abnormal_nervous_system2.30556378
15MP0001542_abnormal_bone_strength2.29208547
16MP0009333_abnormal_splenocyte_physiolog2.27569164
17MP0009785_altered_susceptibility_to2.27196420
18MP0002148_abnormal_hypersensitivity_rea2.12535611
19MP0010030_abnormal_orbit_morphology2.10915668
20MP0003172_abnormal_lysosome_physiology2.08761768
21MP0005464_abnormal_platelet_physiology2.07204906
22MP0000685_abnormal_immune_system2.04381859
23MP0005025_abnormal_response_to1.98890641
24MP0001545_abnormal_hematopoietic_system1.94592632
25MP0005397_hematopoietic_system_phenotyp1.94592632
26MP0006054_spinal_hemorrhage1.93841652
27MP0005000_abnormal_immune_tolerance1.92964861
28MP0005451_abnormal_body_composition1.86351323
29MP0002419_abnormal_innate_immunity1.83994989
30MP0004957_abnormal_blastocyst_morpholog1.81694780
31MP0000750_abnormal_muscle_regeneration1.78418912
32MP0003191_abnormal_cellular_cholesterol1.75225307
33MP0003705_abnormal_hypodermis_morpholog1.69436655
34MP0000858_altered_metastatic_potential1.68432018
35MP0005165_increased_susceptibility_to1.66485999
36MP0000604_amyloidosis1.66321080
37MP0004510_myositis1.64002642
38MP0005083_abnormal_biliary_tract1.63740203
39MP0003329_amyloid_beta_deposits1.62518696
40MP0006082_CNS_inflammation1.60874120
41MP0002398_abnormal_bone_marrow1.60370013
42MP0001819_abnormal_immune_cell1.60072783
43MP0002452_abnormal_antigen_presenting1.60054824
44MP0002723_abnormal_immune_serum1.58061431
45MP0002420_abnormal_adaptive_immunity1.58041619
46MP0005501_abnormal_skin_physiology1.55906060
47MP0001853_heart_inflammation1.54283027
48MP0004859_abnormal_synaptic_plasticity1.53363270
49MP0000358_abnormal_cell_content/1.53040789
50MP0001533_abnormal_skeleton_physiology1.51655355
51MP0000343_altered_response_to1.46724613
52MP0008007_abnormal_cellular_replicative1.44525176
53MP0002722_abnormal_immune_system1.44217250
54MP0006036_abnormal_mitochondrial_physio1.43919976
55MP0000490_abnormal_crypts_of1.43838051
56MP0010352_gastrointestinal_tract_polyps1.43699808
57MP0008469_abnormal_protein_level1.43626204
58MP0002405_respiratory_system_inflammati1.42123153
59MP0003075_altered_response_to1.42090779
60MP0009053_abnormal_anal_canal1.42062864
61MP0000689_abnormal_spleen_morphology1.41959623
62MP0005167_abnormal_blood-brain_barrier1.40376782
63MP0005671_abnormal_response_to1.40349762
64MP0001845_abnormal_inflammatory_respons1.40081574
65MP0002735_abnormal_chemical_nociception1.40041391
66MP0003279_aneurysm1.39919072
67MP0002429_abnormal_blood_cell1.37196615
68MP0001790_abnormal_immune_system1.35840657
69MP0005387_immune_system_phenotype1.35840657
70MP0003786_premature_aging1.34884419
71MP0001800_abnormal_humoral_immune1.33991580
72MP0000716_abnormal_immune_system1.33660946
73MP0001849_ear_inflammation1.30554459
74MP0004233_abnormal_muscle_weight1.29157952
75MP0001968_abnormal_touch/_nociception1.29074700
76MP0003806_abnormal_nucleotide_metabolis1.28614754
77MP0003724_increased_susceptibility_to1.27985804
78MP0003453_abnormal_keratinocyte_physiol1.27779980
79MP0003111_abnormal_nucleus_morphology1.25804846
80MP0003866_abnormal_defecation1.25637739
81MP0004272_abnormal_basement_membrane1.25478379
82MP0004808_abnormal_hematopoietic_stem1.22784653
83MP0003763_abnormal_thymus_physiology1.22365353
84MP0002736_abnormal_nociception_after1.21698658
85MP0003077_abnormal_cell_cycle1.21086386
86MP0005166_decreased_susceptibility_to1.19709803
87MP0002396_abnormal_hematopoietic_system1.19144448
88MP0001727_abnormal_embryo_implantation1.17232481
89MP0010155_abnormal_intestine_physiology1.16607566
90MP0001348_abnormal_lacrimal_gland1.13086309
91MP0001905_abnormal_dopamine_level1.12184892
92MP0004947_skin_inflammation1.12064693
93MP0003300_gastrointestinal_ulcer1.08018475
94MP0002019_abnormal_tumor_incidence1.07545280
95MP0010307_abnormal_tumor_latency1.07405696
96MP0003950_abnormal_plasma_membrane1.07262251
97MP0005584_abnormal_enzyme/coenzyme_acti1.06573703
98MP0003566_abnormal_cell_adhesion1.06306667
99MP0009764_decreased_sensitivity_to1.06037052
100MP0005023_abnormal_wound_healing1.04087646
101MP0002733_abnormal_thermal_nociception1.03679847
102MP0002796_impaired_skin_barrier1.03348278
103MP0003448_altered_tumor_morphology1.03193308
104MP0002089_abnormal_postnatal_growth/wei1.02543280
105MP0005319_abnormal_enzyme/_coenzyme1.02198896
106MP0000313_abnormal_cell_death0.99127269
107MP0005636_abnormal_mineral_homeostasis0.98996389
108MP0002060_abnormal_skin_morphology0.97135186
109MP0000465_gastrointestinal_hemorrhage0.96159061
110MP0010368_abnormal_lymphatic_system0.95313484
111MP0005193_abnormal_anterior_eye0.94788927
112MP0003123_paternal_imprinting0.94333000
113MP0008873_increased_physiological_sensi0.92549078
114MP0003183_abnormal_peptide_metabolism0.91571718
115MP0000703_abnormal_thymus_morphology0.91531527
116MP0001756_abnormal_urination0.91237480
117MP0005310_abnormal_salivary_gland0.91169651
118MP0003315_abnormal_perineum_morphology0.90659750
119MP0003879_abnormal_hair_cell0.90230178
120MP0005670_abnormal_white_adipose0.89228309
121MP0009278_abnormal_bone_marrow0.88854931
122MP0003941_abnormal_skin_development0.87840438
123MP0005197_abnormal_uvea_morphology0.87412873
124MP0009643_abnormal_urine_homeostasis0.87385994
125MP0001663_abnormal_digestive_system0.86840194
126MP0000598_abnormal_liver_morphology0.84171668
127MP0005390_skeleton_phenotype0.83614391
128MP0004811_abnormal_neuron_physiology0.83331138
129MP0004147_increased_porphyrin_level0.82791401
130MP0005408_hypopigmentation0.81903581
131MP0000015_abnormal_ear_pigmentation0.80967399
132MP0008932_abnormal_embryonic_tissue0.80893783
133MP0006035_abnormal_mitochondrial_morpho0.79140338
134MP0001243_abnormal_dermal_layer0.78938663
135MP0005623_abnormal_meninges_morphology0.76296737
136MP0001881_abnormal_mammary_gland0.75593841
137MP0002295_abnormal_pulmonary_circulatio0.75139419
138MP0008874_decreased_physiological_sensi0.72316864
139MP0001216_abnormal_epidermal_layer0.70544278
140MP0002998_abnormal_bone_remodeling0.69525207
141MP0010771_integument_phenotype0.68216584
142MP0000749_muscle_degeneration0.67482901
143MP0005330_cardiomyopathy0.66502231
144MP0002163_abnormal_gland_morphology0.65476062
145MP0000681_abnormal_thyroid_gland0.65113182
146MP0005384_cellular_phenotype0.64905700
147MP0002090_abnormal_vision0.64254213
148MP0008004_abnormal_stomach_pH0.60863111
149MP0003795_abnormal_bone_structure0.60523785
150MP0005508_abnormal_skeleton_morphology0.59974748

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.19943122
2Abnormality of cells of the erythroid lineage (HP:0012130)3.91486915
3Abnormal number of erythroid precursors (HP:0012131)3.87130970
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.83343804
5Acute encephalopathy (HP:0006846)3.58296240
6Elevated erythrocyte sedimentation rate (HP:0003565)3.53455002
7Increased CSF lactate (HP:0002490)3.29729977
8Renal Fanconi syndrome (HP:0001994)3.29549632
9Premature rupture of membranes (HP:0001788)3.27087067
10Eczematoid dermatitis (HP:0000976)3.25571220
11Progressive macrocephaly (HP:0004481)3.13143020
12Rough bone trabeculation (HP:0100670)3.03854426
13Petechiae (HP:0000967)3.02781769
14Increased cerebral lipofuscin (HP:0011813)2.98163216
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.96152044
16Decreased activity of mitochondrial respiratory chain (HP:0008972)2.96152044
17Myokymia (HP:0002411)2.96096140
18Recurrent abscess formation (HP:0002722)2.95963949
19Prolonged neonatal jaundice (HP:0006579)2.95202835
20Increased intramyocellular lipid droplets (HP:0012240)2.92640367
21Vacuolated lymphocytes (HP:0001922)2.91935338
22Thrombocytosis (HP:0001894)2.87899617
23Diminished motivation (HP:0000745)2.78529630
24Poor head control (HP:0002421)2.76151644
25Dysostosis multiplex (HP:0000943)2.76048542
26Vertebral compression fractures (HP:0002953)2.72684413
27Recurrent bacterial skin infections (HP:0005406)2.64298374
28Abnormality of macrophages (HP:0004311)2.61969950
29Abnormality of liposaccharide metabolism (HP:0010968)2.60432293
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.60432293
31Abnormality of glycolipid metabolism (HP:0010969)2.60432293
32Multiple enchondromatosis (HP:0005701)2.60090003
33Increased muscle lipid content (HP:0009058)2.58234097
34Cerebral edema (HP:0002181)2.58085341
35Entropion (HP:0000621)2.54725343
36Respiratory failure (HP:0002878)2.53752466
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53637932
38Upper motor neuron abnormality (HP:0002127)2.53385356
39Hepatosplenomegaly (HP:0001433)2.52790759
40Hypercortisolism (HP:0001578)2.52469597
41Increased hepatocellular lipid droplets (HP:0006565)2.49935327
42Progressive neurologic deterioration (HP:0002344)2.48748161
43Abnormal trabecular bone morphology (HP:0100671)2.47339210
44Abnormality of the heme biosynthetic pathway (HP:0010472)2.46183419
45Reduced subcutaneous adipose tissue (HP:0003758)2.44322755
46Lactic acidosis (HP:0003128)2.42044521
47Loss of speech (HP:0002371)2.41849644
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.40243223
49Exercise intolerance (HP:0003546)2.37723495
50Microretrognathia (HP:0000308)2.37567129
51Apathy (HP:0000741)2.33816490
52Abnormality of the motor neurons (HP:0002450)2.33224618
53Abnormal neuron morphology (HP:0012757)2.33224618
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31172176
55Personality changes (HP:0000751)2.29500731
56Trismus (HP:0000211)2.29140611
57Cholecystitis (HP:0001082)2.28647371
58Abnormal gallbladder physiology (HP:0012438)2.28647371
59Pallor (HP:0000980)2.26359130
60Cellulitis (HP:0100658)2.26000262
61Recurrent gram-negative bacterial infections (HP:0005420)2.25002884
62Systemic lupus erythematosus (HP:0002725)2.23703461
63Autoimmune thrombocytopenia (HP:0001973)2.22518016
64Urinary glycosaminoglycan excretion (HP:0003541)2.22433910
65Mucopolysacchariduria (HP:0008155)2.22433910
66Hypokinesia (HP:0002375)2.22071323
67Interstitial pulmonary disease (HP:0006530)2.21952846
68Testicular atrophy (HP:0000029)2.20306528
69Reticulocytopenia (HP:0001896)2.20027364
70Exertional dyspnea (HP:0002875)2.19773237
71Mediastinal lymphadenopathy (HP:0100721)2.19765164
72Progressive muscle weakness (HP:0003323)2.19576291
73Aplastic anemia (HP:0001915)2.19359774
74Abnormality of the anterior horn cell (HP:0006802)2.18253191
75Degeneration of anterior horn cells (HP:0002398)2.18253191
76Increased serum lactate (HP:0002151)2.17924980
77Nuclear cataract (HP:0100018)2.16945157
78Lipid accumulation in hepatocytes (HP:0006561)2.16646166
79Beaking of vertebral bodies (HP:0004568)2.16456991
80Distal lower limb muscle weakness (HP:0009053)2.15347451
81Increased serum ferritin (HP:0003281)2.14210179
82Ragged-red muscle fibers (HP:0003200)2.13773016
83Hand muscle atrophy (HP:0009130)2.13762472
84Myositis (HP:0100614)2.11830040
85Atrophy/Degeneration involving motor neurons (HP:0007373)2.11780581
86Abnormality of the nasal mucosa (HP:0000433)2.11198612
87Hypertensive crisis (HP:0100735)2.09310699
883-Methylglutaconic aciduria (HP:0003535)2.07659117
89Urticaria (HP:0001025)2.07131958
90Neoplasm of head and neck (HP:0012288)2.05564962
91Esophageal neoplasm (HP:0100751)2.05564962
92Fasciculations (HP:0002380)2.03865518
93Nonimmune hydrops fetalis (HP:0001790)2.03692242
94Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.01409004
95Abnormality of reticulocytes (HP:0004312)2.00065275
96Congenital ichthyosiform erythroderma (HP:0007431)1.99561725
97Supranuclear gaze palsy (HP:0000605)1.99103746
98Delusions (HP:0000746)1.98489485
99Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98362915
100Respiratory difficulties (HP:0002880)1.97828576
101Short nail (HP:0001799)1.97603914
102Abnormality of polysaccharide metabolism (HP:0011012)1.97430329
103Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97430329
104Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97430329
105Growth hormone excess (HP:0000845)1.97008176
106Nasal polyposis (HP:0100582)1.96676220
107Abnormality of T cell physiology (HP:0011840)1.96264656
108Polygenic inheritance (HP:0010982)1.95588534
109Abnormality of the distal phalanges of the toes (HP:0010182)1.95194588
110Amyloidosis (HP:0011034)1.93952284
111Opisthotonus (HP:0002179)1.93930394
112Peritonitis (HP:0002586)1.91974672
113Basal ganglia calcification (HP:0002135)1.91408669
114Mutism (HP:0002300)1.90387606
115Sparse eyelashes (HP:0000653)1.90078419
116Cerebral hypomyelination (HP:0006808)1.89996287
117Reticulocytosis (HP:0001923)1.88836599
118Axonal loss (HP:0003447)1.88502790
119Abnormality of the umbilical cord (HP:0010881)1.87172725
120Macrocytic anemia (HP:0001972)1.86994142
121Hepatocellular necrosis (HP:0001404)1.85170294
122Large eyes (HP:0001090)1.84865060
123Achilles tendon contracture (HP:0001771)1.84219833
124Myocardial infarction (HP:0001658)1.83976513
125Recurrent fungal infections (HP:0002841)1.83763269
126Joint stiffness (HP:0001387)1.82625124
127Purpura (HP:0000979)1.81419681
128Obstructive lung disease (HP:0006536)1.78402776
129Chronic obstructive pulmonary disease (HP:0006510)1.78402776
130Abnormality of glycolysis (HP:0004366)1.77069933
131Recurrent skin infections (HP:0001581)1.76667958
132Emotional lability (HP:0000712)1.76265368
133Protrusio acetabuli (HP:0003179)1.76130532
134Progressive microcephaly (HP:0000253)1.75925802
135Abnormal platelet function (HP:0011869)1.75866423
136Impaired platelet aggregation (HP:0003540)1.75866423
137Hepatic necrosis (HP:0002605)1.75677531
138Abnormal delayed hypersensitivity skin test (HP:0002963)1.75270660
139Upper limb amyotrophy (HP:0009129)1.75197342
140Distal upper limb amyotrophy (HP:0007149)1.75197342
141Insomnia (HP:0100785)1.74957704
142Generalized aminoaciduria (HP:0002909)1.74763638
143Increased serum pyruvate (HP:0003542)1.73593547
144Nausea (HP:0002018)1.72878899
145Abnormality of the vocal cords (HP:0008777)1.72574498
146Reduced antithrombin III activity (HP:0001976)1.72573538
147Spastic paraparesis (HP:0002313)1.72454592
148Ankle contracture (HP:0006466)1.71815525
149Abnormal mitochondria in muscle tissue (HP:0008316)1.71126077
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70243738
151Abnormality of the Achilles tendon (HP:0005109)1.68703458
152Mitochondrial inheritance (HP:0001427)1.68014745
153Polycythemia (HP:0001901)1.67676845
154Papilloma (HP:0012740)1.67198402
155Verrucae (HP:0200043)1.67198402
156Carpal bone hypoplasia (HP:0001498)1.66418629
157Type I transferrin isoform profile (HP:0003642)1.66170582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.65066235
2TRIB33.51399439
3TESK23.44764196
4TESK13.40983031
5NME23.35045919
6ERN13.17321247
7IRAK33.14424777
8SCYL22.99706257
9KDR2.80759130
10ARAF2.71654693
11MAP3K112.45896426
12PKN22.39995953
13BUB12.31298115
14PIM22.28232052
15LIMK12.09735234
16MAP4K12.01555391
17BLK1.99284169
18NEK11.85142506
19MAP3K121.81960090
20ZAP701.65947735
21KSR21.62333641
22PBK1.56302216
23EPHA21.54225831
24TBK11.52432539
25ILK1.43899058
26LRRK21.42629056
27MAP3K91.41921651
28CAMKK11.41147282
29MAPKAPK31.38039464
30PAK41.33513785
31EPHB21.30410429
32CAMKK21.29383909
33DAPK31.28556052
34BRAF1.25390029
35TAOK11.24200247
36DAPK11.22314099
37BCKDK1.20691845
38EIF2AK11.19988966
39SMG11.18351672
40CDK191.16447469
41WEE11.13360080
42EEF2K1.12434697
43BRSK11.09260586
44MAP3K101.05423494
45MINK11.05409991
46DAPK21.04271308
47RPS6KA41.02004618
48MAP3K10.95752133
49PTK20.95243424
50PDK20.94930147
51MAP3K30.94453208
52LMTK20.92644495
53GRK60.92608280
54SYK0.88640095
55NEK20.88099224
56MAP3K80.88047189
57ABL20.85005902
58TGFBR20.83753639
59MAP2K60.82479190
60PAK10.81331408
61TYK20.81111644
62CSNK1G30.80675822
63JAK30.80183927
64VRK10.79738492
65ICK0.77626582
66STK160.74036382
67MAP2K30.72163646
68NTRK10.69805017
69EIF2AK30.69786496
70KIT0.68672618
71PRKG20.68459974
72MATK0.68075448
73AURKA0.65860142
74MAP2K20.64723835
75RAF10.63978328
76CDK140.63630230
77MAP2K70.61658047
78FLT30.61052571
79MAP2K10.59750180
80LATS20.59687573
81DMPK0.59581655
82BTK0.59063551
83ALK0.57871353
84CDK150.54114558
85CDK180.53950130
86CDK11A0.53548106
87GRK70.53495745
88CDK80.53185663
89CAMK2G0.53024786
90TLK10.52698077
91ERBB40.51608878
92MST1R0.51211777
93BMX0.50440529
94CCNB10.49607984
95PRKD30.48799100
96IKBKB0.47300497
97CSNK1A1L0.47087743
98RET0.46720417
99DDR20.46651445
100IRAK40.46301384
101GRK50.45495760
102TGFBR10.44836721
103AURKB0.44624562
104RIPK40.43803282
105SIK30.43326415
106MAP3K20.43265080
107MARK10.41888277
108CSNK1G20.41767897
109DYRK30.41360125
110RPS6KA20.40814451
111CDK70.40615261
112TTN0.40397358
113PRKCD0.40375157
114AKT20.39669535
115PRKCI0.39570383
116JAK20.39061437
117PLK10.38894370
118BRSK20.38564337
119RPS6KB20.38337314
120CHEK20.38244692
121CDC70.38025197
122STK100.35433849
123NEK90.34539971
124SIK10.33925548
125PAK20.33823668
126NME10.33560143
127RPS6KA50.33510205
128PIM10.33225078
129MYLK0.32776115
130MAP3K130.31834456
131TAOK20.31770630
132SIK20.31531246
133STK40.31412044
134CSNK2A10.31179512
135IRAK20.30924544
136MAP3K50.30359515
137DYRK20.30155912
138MOS0.30126080
139PAK60.29110944
140PRPF4B0.28329991
141CSNK1G10.28078961
142CSNK2A20.26617984
143ZAK0.26145708

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.41264389
2Ribosome_Homo sapiens_hsa030104.07539313
3DNA replication_Homo sapiens_hsa030303.44461581
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.17027660
5Sulfur relay system_Homo sapiens_hsa041222.02959212
6Shigellosis_Homo sapiens_hsa051311.89224144
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.87549572
8Pyrimidine metabolism_Homo sapiens_hsa002401.81154542
9Lysosome_Homo sapiens_hsa041421.75723089
10Parkinsons disease_Homo sapiens_hsa050121.75642332
11* Synaptic vesicle cycle_Homo sapiens_hsa047211.73601097
12Pentose phosphate pathway_Homo sapiens_hsa000301.71083800
13Base excision repair_Homo sapiens_hsa034101.65481175
14Leishmaniasis_Homo sapiens_hsa051401.65380348
15Fatty acid elongation_Homo sapiens_hsa000621.63124827
16Sulfur metabolism_Homo sapiens_hsa009201.62552918
17Folate biosynthesis_Homo sapiens_hsa007901.58402123
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51221014
19N-Glycan biosynthesis_Homo sapiens_hsa005101.50244071
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47507698
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47251429
22Legionellosis_Homo sapiens_hsa051341.45223464
23Oxidative phosphorylation_Homo sapiens_hsa001901.44833539
24Spliceosome_Homo sapiens_hsa030401.40409058
25Mismatch repair_Homo sapiens_hsa034301.39336620
26Galactose metabolism_Homo sapiens_hsa000521.38565848
27Other glycan degradation_Homo sapiens_hsa005111.37201152
28Salmonella infection_Homo sapiens_hsa051321.34549809
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34403929
30Vibrio cholerae infection_Homo sapiens_hsa051101.30696710
31Pertussis_Homo sapiens_hsa051331.29037573
32Antigen processing and presentation_Homo sapiens_hsa046121.25667064
33* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25550893
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24271662
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.23890398
36Apoptosis_Homo sapiens_hsa042101.21272776
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21234772
38RNA polymerase_Homo sapiens_hsa030201.20441825
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20231258
40Tuberculosis_Homo sapiens_hsa051521.17625326
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15680560
42Phagosome_Homo sapiens_hsa041451.15435812
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15223728
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11269143
45Cardiac muscle contraction_Homo sapiens_hsa042601.10659538
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10336869
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10314214
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.09667207
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08018217
50Thyroid cancer_Homo sapiens_hsa052161.07239381
51Fructose and mannose metabolism_Homo sapiens_hsa000511.03811855
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.03583705
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.02398298
54Huntingtons disease_Homo sapiens_hsa050160.95784820
55Collecting duct acid secretion_Homo sapiens_hsa049660.91083512
56Alzheimers disease_Homo sapiens_hsa050100.89004052
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85631353
58Asthma_Homo sapiens_hsa053100.84885549
59Epstein-Barr virus infection_Homo sapiens_hsa051690.83554487
60Homologous recombination_Homo sapiens_hsa034400.83197997
61Nucleotide excision repair_Homo sapiens_hsa034200.82474557
62Bladder cancer_Homo sapiens_hsa052190.80363634
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79683682
64VEGF signaling pathway_Homo sapiens_hsa043700.79638688
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.79048888
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78940768
67Vitamin B6 metabolism_Homo sapiens_hsa007500.78659307
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78365087
69* Endocytosis_Homo sapiens_hsa041440.77898139
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77096669
71Acute myeloid leukemia_Homo sapiens_hsa052210.76514793
72Chronic myeloid leukemia_Homo sapiens_hsa052200.75401308
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75338268
74Osteoclast differentiation_Homo sapiens_hsa043800.75275143
75Biosynthesis of amino acids_Homo sapiens_hsa012300.74703133
76Prion diseases_Homo sapiens_hsa050200.74046444
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73795344
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73481898
79RNA transport_Homo sapiens_hsa030130.73026311
80Carbon metabolism_Homo sapiens_hsa012000.71216361
81Pyruvate metabolism_Homo sapiens_hsa006200.71181627
82Protein export_Homo sapiens_hsa030600.70766218
83Cell cycle_Homo sapiens_hsa041100.69549566
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69194988
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65625377
86Metabolic pathways_Homo sapiens_hsa011000.64932901
87B cell receptor signaling pathway_Homo sapiens_hsa046620.64778101
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64482310
89p53 signaling pathway_Homo sapiens_hsa041150.62479472
90Purine metabolism_Homo sapiens_hsa002300.60566004
91Hepatitis B_Homo sapiens_hsa051610.60228694
92Glutathione metabolism_Homo sapiens_hsa004800.57896011
93HIF-1 signaling pathway_Homo sapiens_hsa040660.57723914
94Viral carcinogenesis_Homo sapiens_hsa052030.56555017
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56515414
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55692416
97Measles_Homo sapiens_hsa051620.55248788
98Influenza A_Homo sapiens_hsa051640.54232426
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53913891
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.53173333
101Rheumatoid arthritis_Homo sapiens_hsa053230.51411845
102Oocyte meiosis_Homo sapiens_hsa041140.48679127
103Systemic lupus erythematosus_Homo sapiens_hsa053220.48356520
104Staphylococcus aureus infection_Homo sapiens_hsa051500.47022760
105TNF signaling pathway_Homo sapiens_hsa046680.46876242
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45661072
107Malaria_Homo sapiens_hsa051440.44414751
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44240821
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43754357
110Phenylalanine metabolism_Homo sapiens_hsa003600.43616360
111Primary immunodeficiency_Homo sapiens_hsa053400.43317074
112Alcoholism_Homo sapiens_hsa050340.42455024
113Non-small cell lung cancer_Homo sapiens_hsa052230.42250819
114Toxoplasmosis_Homo sapiens_hsa051450.41335052
115Olfactory transduction_Homo sapiens_hsa047400.41249836
116Regulation of autophagy_Homo sapiens_hsa041400.38696845
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36290919
118Viral myocarditis_Homo sapiens_hsa054160.34945242
119Tyrosine metabolism_Homo sapiens_hsa003500.33556717
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32133760
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29614962
122One carbon pool by folate_Homo sapiens_hsa006700.29118012
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28212286
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.24796262
125Mineral absorption_Homo sapiens_hsa049780.23492960
126Arginine and proline metabolism_Homo sapiens_hsa003300.21507297
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19764181
128Sphingolipid metabolism_Homo sapiens_hsa006000.19422564
129HTLV-I infection_Homo sapiens_hsa051660.16080208
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14157602
131Steroid biosynthesis_Homo sapiens_hsa001000.13874337

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