AP3B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.77747791
2positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.77747791
3positive regulation of mitotic sister chromatid separation (GO:1901970)4.77747791
4negative regulation of DNA repair (GO:0045738)4.38716323
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.38333278
6protein localization to chromosome, centromeric region (GO:0071459)3.77414919
7cell adhesion mediated by integrin (GO:0033627)3.65847961
8positive regulation of chromosome segregation (GO:0051984)3.65228851
9positive regulation of gamma-delta T cell activation (GO:0046645)3.58197866
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57987240
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57987240
12monoubiquitinated protein deubiquitination (GO:0035520)3.56701528
13positive regulation of interferon-alpha production (GO:0032727)3.53576067
14antigen processing and presentation of endogenous antigen (GO:0019883)3.44033358
15protein K11-linked deubiquitination (GO:0035871)3.38461460
16regulation of centriole replication (GO:0046599)3.37071908
17positive regulation by symbiont of host defense response (GO:0052509)3.36676424
18modulation by symbiont of host defense response (GO:0052031)3.36676424
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36676424
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36676424
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.36676424
22modulation by symbiont of host immune response (GO:0052553)3.36676424
23protein localization to kinetochore (GO:0034501)3.36003578
24oligosaccharide catabolic process (GO:0009313)3.35078113
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34730051
26regulation of interferon-alpha production (GO:0032647)3.33628921
27COPII vesicle coating (GO:0048208)3.24768623
28immunoglobulin mediated immune response (GO:0016064)3.21371393
29establishment of chromosome localization (GO:0051303)3.17121598
30non-recombinational repair (GO:0000726)3.14327238
31double-strand break repair via nonhomologous end joining (GO:0006303)3.14327238
32nuclear pore complex assembly (GO:0051292)3.13670075
33sister chromatid segregation (GO:0000819)3.11430343
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10632951
35neutrophil activation involved in immune response (GO:0002283)3.10121320
36UDP-N-acetylglucosamine metabolic process (GO:0006047)3.09795842
37NIK/NF-kappaB signaling (GO:0038061)3.08117589
38response to X-ray (GO:0010165)3.03358612
39Golgi transport vesicle coating (GO:0048200)3.00648745
40COPI coating of Golgi vesicle (GO:0048205)3.00648745
41metaphase plate congression (GO:0051310)2.99727407
42mitotic metaphase plate congression (GO:0007080)2.98597833
43microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.96569022
44regulation of interferon-beta biosynthetic process (GO:0045357)2.95126027
45cellular response to vitamin D (GO:0071305)2.95031640
46mitotic sister chromatid segregation (GO:0000070)2.91997201
47B cell mediated immunity (GO:0019724)2.91826778
48regulation of sister chromatid cohesion (GO:0007063)2.90533971
49regulation of RNA export from nucleus (GO:0046831)2.89483162
50nuclear pore organization (GO:0006999)2.87202818
51positive regulation of B cell differentiation (GO:0045579)2.84643101
52mitotic G2/M transition checkpoint (GO:0044818)2.82913317
53hepatocyte apoptotic process (GO:0097284)2.82866852
54natural killer cell mediated cytotoxicity (GO:0042267)2.81955244
55natural killer cell mediated immunity (GO:0002228)2.81955244
56positive regulation of protein import into nucleus, translocation (GO:0033160)2.79449593
57response to interferon-alpha (GO:0035455)2.78647713
58cytoskeleton-dependent cytokinesis (GO:0061640)2.75684914
59histone-serine phosphorylation (GO:0035404)2.75423518
60spindle assembly involved in mitosis (GO:0090307)2.74948153
61pore complex assembly (GO:0046931)2.73729901
62regulation of interleukin-12 biosynthetic process (GO:0045075)2.73074269
63positive regulation of natural killer cell differentiation (GO:0032825)2.71923682
64negative regulation of fibroblast apoptotic process (GO:2000270)2.70910756
65cytokine secretion (GO:0050663)2.70849383
66response to peptidoglycan (GO:0032494)2.70801426
67positive regulation of interferon-beta production (GO:0032728)2.67894691
68DNA geometric change (GO:0032392)2.66941666
69regulation of gamma-delta T cell differentiation (GO:0045586)2.65968428
70wound healing, spreading of epidermal cells (GO:0035313)2.63899180
71DNA duplex unwinding (GO:0032508)2.63473033
72attachment of spindle microtubules to kinetochore (GO:0008608)2.62508304
73membrane raft organization (GO:0031579)2.62078233
74regulation of gamma-delta T cell activation (GO:0046643)2.59635186
75pinocytosis (GO:0006907)2.59359181
76mitotic G2 DNA damage checkpoint (GO:0007095)2.59275921
77response to muramyl dipeptide (GO:0032495)2.59247703
78regulation of RIG-I signaling pathway (GO:0039535)2.58250948
79positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.56794636
80embryonic process involved in female pregnancy (GO:0060136)2.56469398
81response to type I interferon (GO:0034340)2.54582133
82cellular response to interferon-alpha (GO:0035457)2.54069030
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.53556623
84production of molecular mediator involved in inflammatory response (GO:0002532)2.52700479
85signal peptide processing (GO:0006465)2.51997824
86type I interferon signaling pathway (GO:0060337)2.51386999
87cellular response to type I interferon (GO:0071357)2.51386999
88regulation of centrosome duplication (GO:0010824)2.50367493
89neutrophil activation (GO:0042119)2.49823690
90endosome to melanosome transport (GO:0035646)2.49677979
91endosome to pigment granule transport (GO:0043485)2.49677979
92regulation of centrosome cycle (GO:0046605)2.48657138
93snRNA transcription (GO:0009301)2.47436162
94regulation of integrin activation (GO:0033623)2.47347816
95positive regulation of protein autophosphorylation (GO:0031954)2.46058523
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45901035
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45901035
98negative thymic T cell selection (GO:0045060)2.45680839
99granulocyte activation (GO:0036230)2.44320760
100somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44305122
101isotype switching (GO:0045190)2.44305122
102somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44305122
103replication fork processing (GO:0031297)2.43384902
104mitotic cytokinesis (GO:0000281)2.42455271
105regulation of chromosome segregation (GO:0051983)2.42332210
106regulation of Rac protein signal transduction (GO:0035020)2.40712794
107sphingosine metabolic process (GO:0006670)2.40243306
108regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39253934
109nuclear envelope organization (GO:0006998)2.38393763
110response to UV-C (GO:0010225)2.37592562
111regulation of necroptotic process (GO:0060544)2.37477291
112actin nucleation (GO:0045010)2.36447839
113negative T cell selection (GO:0043383)2.35884035
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.35614445
115regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35052783
116folic acid-containing compound biosynthetic process (GO:0009396)2.34626991
117regulation of mitotic sister chromatid segregation (GO:0033047)2.34123022
118regulation of sister chromatid segregation (GO:0033045)2.34123022
119regulation of mitotic sister chromatid separation (GO:0010965)2.34123022
120regulation of B cell differentiation (GO:0045577)2.33502795
121negative regulation of B cell proliferation (GO:0030889)2.33455800
122natural killer cell differentiation (GO:0001779)2.33007246
123positive regulation of isotype switching (GO:0045830)2.32964179
124positive regulation of histone H3-K4 methylation (GO:0051571)2.32800817
125T-helper 1 type immune response (GO:0042088)2.31939558
126replicative senescence (GO:0090399)2.31215464
127cellular response to virus (GO:0098586)2.29813205
128Golgi organization (GO:0007030)2.29771322
129regulation of protein import into nucleus, translocation (GO:0033158)2.29683837
130spindle checkpoint (GO:0031577)2.29586002
131mitotic nuclear envelope disassembly (GO:0007077)2.29410526
132negative regulation of interleukin-12 production (GO:0032695)2.29255623
133macrophage activation involved in immune response (GO:0002281)2.29010150
134regulation of B cell receptor signaling pathway (GO:0050855)2.28870720
135cellular response to ethanol (GO:0071361)2.27732252
136phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27224647
137DNA conformation change (GO:0071103)2.25935218
138glomerular visceral epithelial cell development (GO:0072015)2.25475387
139myelin assembly (GO:0032288)2.25469140
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25243658
141positive regulation of antigen processing and presentation (GO:0002579)2.24983981
142regulation of interferon-beta production (GO:0032648)2.24873432
143somatic recombination of immunoglobulin gene segments (GO:0016447)2.24323146
144regulation of spindle organization (GO:0090224)2.23530435
145skin morphogenesis (GO:0043589)2.22538064
146leukocyte aggregation (GO:0070486)2.21568391
147histone mRNA catabolic process (GO:0071044)2.21027834
148cellular response to ionizing radiation (GO:0071479)2.20444683
149inner cell mass cell proliferation (GO:0001833)2.19993413
150pre-miRNA processing (GO:0031054)2.19977777
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19660211
152pericardium development (GO:0060039)2.19445645
153iron ion import (GO:0097286)2.19302699
154protein localization to chromosome (GO:0034502)2.19077308
155positive regulation of macrophage differentiation (GO:0045651)2.18837701
156cellular extravasation (GO:0045123)2.18796938
157positive regulation of defense response to virus by host (GO:0002230)2.18451197
158hemidesmosome assembly (GO:0031581)2.17771027
159ventricular cardiac muscle cell development (GO:0055015)2.17403213
160interkinetic nuclear migration (GO:0022027)2.16890480
161regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.16721084
162positive thymic T cell selection (GO:0045059)2.15147366
163positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.15043800
164mitotic sister chromatid cohesion (GO:0007064)2.14719674
165heterochromatin organization (GO:0070828)2.14686005
166T cell apoptotic process (GO:0070231)2.14681296
167low-density lipoprotein particle clearance (GO:0034383)2.12603208
168myeloid dendritic cell activation (GO:0001773)2.12068364
169apoptotic cell clearance (GO:0043277)2.11527186
170regulation of alpha-beta T cell proliferation (GO:0046640)2.11444371
171negative regulation of viral genome replication (GO:0045071)2.11420282
172nuclear envelope disassembly (GO:0051081)2.10454486
173membrane disassembly (GO:0030397)2.10454486
174negative regulation of granulocyte differentiation (GO:0030853)2.10019560
175leukocyte cell-cell adhesion (GO:0007159)2.09604465
176interferon-gamma-mediated signaling pathway (GO:0060333)2.07328162
177response to host immune response (GO:0052572)2.07255010
178response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.07255010
179regulation of cholesterol storage (GO:0010885)2.06393498
180regulation of response to interferon-gamma (GO:0060330)2.06020508
181regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.05661068
182regulation of dendritic cell antigen processing and presentation (GO:0002604)2.05295605
183positive regulation of alpha-beta T cell proliferation (GO:0046641)2.04925855
184response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.04473925
185response to host (GO:0075136)2.04473925
186response to host defenses (GO:0052200)2.04473925
187regulation of interleukin-12 production (GO:0032655)2.03487202
188mitotic chromosome condensation (GO:0007076)2.03290326
1893-UTR-mediated mRNA stabilization (GO:0070935)2.02922687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.76208504
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.30754864
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.11093615
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.62641810
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09584527
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91581465
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.86815142
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.78323773
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70521900
10ELK1_19687146_ChIP-ChIP_HELA_Human2.59980198
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56158692
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.46628940
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.46295155
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44793605
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43072854
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41989344
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39911950
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34497059
19MYC_22102868_ChIP-Seq_BL_Human2.26040697
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.24964966
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.23862467
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21416913
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16009332
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13394472
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11468608
26BRD4_25478319_ChIP-Seq_HGPS_Human2.07494603
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.04611539
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03921443
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00742315
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99489392
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88814643
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87231337
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.85877796
34SCL_19346495_ChIP-Seq_HPC-7_Human1.85693527
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83420356
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83220537
37MYB_26560356_Chip-Seq_TH2_Human1.80140188
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.80119231
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.78700386
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78285588
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77321047
42SPI1_23547873_ChIP-Seq_NB4_Human1.76877405
43VDR_21846776_ChIP-Seq_THP-1_Human1.73998711
44* MYB_26560356_Chip-Seq_TH1_Human1.72173549
45MAF_26560356_Chip-Seq_TH1_Human1.68576895
46* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67834414
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66142229
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65018048
49* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63682809
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63333085
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61399986
52SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61269649
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58377172
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55503798
55TCF7_22412390_ChIP-Seq_EML_Mouse1.52991211
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52863541
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.51415162
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.51312327
59FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50281252
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.48780111
61VDR_24763502_ChIP-Seq_THP-1_Human1.44157226
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42667449
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42298863
64RUNX_20019798_ChIP-Seq_JUKART_Human1.42201230
65UTX_26944678_Chip-Seq_JUKART_Human1.39418498
66* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32600367
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32534058
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32141967
69* SPI1_23127762_ChIP-Seq_K562_Human1.30468051
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.29353260
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28359359
72* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27850694
73TFEB_21752829_ChIP-Seq_HELA_Human1.27282250
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.26575323
75PU_27001747_Chip-Seq_BMDM_Mouse1.26279115
76* EWS_26573619_Chip-Seq_HEK293_Human1.26025582
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24197605
78AR_21909140_ChIP-Seq_LNCAP_Human1.24046453
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23428814
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22551539
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20314925
82FUS_26573619_Chip-Seq_HEK293_Human1.19416537
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19322988
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19283189
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18433998
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17180386
87CJUN_26792858_Chip-Seq_BT549_Human1.17055206
88* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16723723
89TP53_16413492_ChIP-PET_HCT116_Human1.14888572
90* VDR_23849224_ChIP-Seq_CD4+_Human1.14411747
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12591805
92* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11948835
93ELK3_25401928_ChIP-Seq_HUVEC_Human1.11942520
94DCP1A_22483619_ChIP-Seq_HELA_Human1.11390680
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11252236
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11030166
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08985531
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08747904
99CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08571370
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.07780713
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.06907214
102NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06313538
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06313538
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05515036
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05159468
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03691592
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03049168
108GATA3_27048872_Chip-Seq_THYMUS_Human1.02859528
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02534268
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00695504
111CDX2_22108803_ChIP-Seq_LS180_Human1.00181462
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99892655
113* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99493524
114MYC_18555785_ChIP-Seq_MESCs_Mouse0.99265293
115NCOR1_26117541_ChIP-Seq_K562_Human0.98991703
116* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98246255
117* FOXP3_21729870_ChIP-Seq_TREG_Human0.97971667
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.95507127
119PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95341269
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94990928
121MAF_26560356_Chip-Seq_TH2_Human0.94656558
122EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93652433
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92496276
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92020081
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91789084
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91700723
127RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.91524207
128* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91442242
129KDM2B_26808549_Chip-Seq_DND41_Human0.91085818
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90776488
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.90763495
132* ELF5_23300383_ChIP-Seq_T47D_Human0.90337531
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.90212697
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89583434
135* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88726252
136GATA6_25053715_ChIP-Seq_YYC3_Human0.88541324
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88454646
138ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88279273
139* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87598620
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87529820
141SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86761499
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85541971
143ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84902044
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84200657
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.84136824
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.83995610
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83898727
148PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83584116
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83335193
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82874236
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82858120
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82858120
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.82738821
154* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82274719
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82078043
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81569182
157GATA1_22025678_ChIP-Seq_K562_Human0.80356610
158NELFA_20434984_ChIP-Seq_ESCs_Mouse0.79477480
159NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78483517
160* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78267364
161GATA3_26560356_Chip-Seq_TH2_Human0.76631181
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75993590
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75175234
164KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74764652
165KDM5A_27292631_Chip-Seq_BREAST_Human0.74593988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.10007372
2MP0003950_abnormal_plasma_membrane2.98512134
3MP0003436_decreased_susceptibility_to2.36857998
4MP0000685_abnormal_immune_system2.27500703
5* MP0000569_abnormal_digit_pigmentation2.27001792
6MP0010352_gastrointestinal_tract_polyps2.26234596
7MP0009785_altered_susceptibility_to2.09836454
8MP0005671_abnormal_response_to2.05873802
9MP0009697_abnormal_copulation1.97669556
10MP0005000_abnormal_immune_tolerance1.97101255
11MP0010307_abnormal_tumor_latency1.96867015
12MP0002419_abnormal_innate_immunity1.94352376
13MP0003300_gastrointestinal_ulcer1.93802292
14MP0002452_abnormal_antigen_presenting1.93148878
15MP0005076_abnormal_cell_differentiation1.92806387
16MP0001800_abnormal_humoral_immune1.92273992
17MP0010678_abnormal_skin_adnexa1.92110437
18MP0002396_abnormal_hematopoietic_system1.91291047
19* MP0005025_abnormal_response_to1.89540332
20MP0002148_abnormal_hypersensitivity_rea1.89349319
21MP0009278_abnormal_bone_marrow1.86641473
22* MP0005408_hypopigmentation1.86540513
23MP0001790_abnormal_immune_system1.86067024
24MP0005387_immune_system_phenotype1.86067024
25MP0003566_abnormal_cell_adhesion1.83401862
26MP0006082_CNS_inflammation1.82897280
27MP0002166_altered_tumor_susceptibility1.81312884
28MP0003705_abnormal_hypodermis_morpholog1.81152096
29MP0004947_skin_inflammation1.79692458
30MP0004808_abnormal_hematopoietic_stem1.79493916
31MP0003941_abnormal_skin_development1.78708172
32MP0002723_abnormal_immune_serum1.77005612
33MP0003303_peritoneal_inflammation1.73098213
34MP0001545_abnormal_hematopoietic_system1.72158022
35MP0005397_hematopoietic_system_phenotyp1.72158022
36MP0003724_increased_susceptibility_to1.69554634
37MP0001819_abnormal_immune_cell1.67871825
38MP0002006_tumorigenesis1.67799229
39MP0004272_abnormal_basement_membrane1.66838328
40MP0002420_abnormal_adaptive_immunity1.66401694
41* MP0005464_abnormal_platelet_physiology1.59211469
42* MP0002398_abnormal_bone_marrow1.57092529
43* MP0002405_respiratory_system_inflammati1.56934032
44MP0010155_abnormal_intestine_physiology1.55866558
45MP0003448_altered_tumor_morphology1.54635966
46MP0000858_altered_metastatic_potential1.49247737
47* MP0005058_abnormal_lysosome_morphology1.46250027
48MP0008058_abnormal_DNA_repair1.44866984
49* MP0000716_abnormal_immune_system1.43225681
50MP0008057_abnormal_DNA_replication1.41243501
51MP0002060_abnormal_skin_morphology1.39942126
52MP0001845_abnormal_inflammatory_respons1.39273930
53MP0006054_spinal_hemorrhage1.38645047
54MP0002877_abnormal_melanocyte_morpholog1.37926249
55MP0003890_abnormal_embryonic-extraembry1.37764564
56MP0000427_abnormal_hair_cycle1.35897904
57MP0001533_abnormal_skeleton_physiology1.35206478
58MP0002009_preneoplasia1.34417529
59MP0003763_abnormal_thymus_physiology1.33194690
60MP0000689_abnormal_spleen_morphology1.32952886
61MP0002722_abnormal_immune_system1.32227999
62MP0000383_abnormal_hair_follicle1.32224311
63MP0003693_abnormal_embryo_hatching1.31815245
64MP0000490_abnormal_crypts_of1.30670312
65MP0003077_abnormal_cell_cycle1.29601793
66MP0004510_myositis1.27218928
67MP0008932_abnormal_embryonic_tissue1.26670268
68* MP0002429_abnormal_blood_cell1.26203343
69MP0001853_heart_inflammation1.25487976
70MP0005275_abnormal_skin_tensile1.23592406
71MP0009333_abnormal_splenocyte_physiolog1.23085790
72MP0010094_abnormal_chromosome_stability1.21894642
73MP0005023_abnormal_wound_healing1.21540940
74MP0003111_abnormal_nucleus_morphology1.21466211
75MP0001873_stomach_inflammation1.20691747
76* MP0000371_diluted_coat_color1.16857698
77MP0008469_abnormal_protein_level1.13316425
78MP0003984_embryonic_growth_retardation1.12113835
79MP0003806_abnormal_nucleotide_metabolis1.11591349
80MP0005310_abnormal_salivary_gland1.11313963
81MP0009780_abnormal_chondrocyte_physiolo1.11291861
82MP0002138_abnormal_hepatobiliary_system1.10622825
83MP0002088_abnormal_embryonic_growth/wei1.10562209
84MP0003656_abnormal_erythrocyte_physiolo1.10455776
85MP0001672_abnormal_embryogenesis/_devel1.09338554
86MP0005380_embryogenesis_phenotype1.09338554
87MP0001697_abnormal_embryo_size1.08808048
88MP0005257_abnormal_intraocular_pressure1.07617990
89MP0009840_abnormal_foam_cell1.06329227
90MP0008438_abnormal_cutaneous_collagen1.04924877
91MP0000703_abnormal_thymus_morphology1.04206093
92MP0003091_abnormal_cell_migration1.01039553
93MP0008007_abnormal_cellular_replicative1.00824718
94MP0002998_abnormal_bone_remodeling0.99644519
95MP0003453_abnormal_keratinocyte_physiol0.99566927
96* MP0003172_abnormal_lysosome_physiology0.99537100
97MP0000647_abnormal_sebaceous_gland0.99269654
98MP0004957_abnormal_blastocyst_morpholog0.98348192
99MP0009764_decreased_sensitivity_to0.97910298
100MP0002084_abnormal_developmental_patter0.97073486
101MP0001849_ear_inflammation0.96931494
102MP0002019_abnormal_tumor_incidence0.96438909
103MP0004264_abnormal_extraembryonic_tissu0.96340113
104MP0003191_abnormal_cellular_cholesterol0.96125021
105MP0001661_extended_life_span0.95263650
106MP0000465_gastrointestinal_hemorrhage0.95077868
107MP0001216_abnormal_epidermal_layer0.92498550
108MP0000350_abnormal_cell_proliferation0.91275198
109MP0003195_calcinosis0.90876255
110MP0000358_abnormal_cell_content/0.90559347
111MP0001243_abnormal_dermal_layer0.88600848
112MP0002254_reproductive_system_inflammat0.88152268
113MP0000377_abnormal_hair_follicle0.87997434
114MP0000733_abnormal_muscle_development0.87432021
115MP0003045_fibrosis0.86961223
116MP0002168_other_aberrant_phenotype0.86954251
117MP0000627_abnormal_mammary_gland0.83952522
118MP0002896_abnormal_bone_mineralization0.83857751
119MP0000343_altered_response_to0.83687595
120* MP0005174_abnormal_tail_pigmentation0.83426731
121MP0005395_other_phenotype0.82906340
122MP0002086_abnormal_extraembryonic_tissu0.82883688
123MP0001191_abnormal_skin_condition0.81117913
124MP0002933_joint_inflammation0.80105723
125MP0009763_increased_sensitivity_to0.79753631
126MP0005621_abnormal_cell_physiology0.79144018
127MP0000372_irregular_coat_pigmentation0.79099562
128MP0000598_abnormal_liver_morphology0.78816924
129MP0003828_pulmonary_edema0.78695491
130MP0008260_abnormal_autophagy0.78224378
131MP0003718_maternal_effect0.77064068
132MP0003866_abnormal_defecation0.76713378
133MP0005384_cellular_phenotype0.76165066
134MP0001915_intracranial_hemorrhage0.75389582
135MP0000767_abnormal_smooth_muscle0.74902905
136MP0001730_embryonic_growth_arrest0.74774281
137MP0005197_abnormal_uvea_morphology0.73958588
138MP0004233_abnormal_muscle_weight0.73395721
139MP0000313_abnormal_cell_death0.73337498
140* MP0001186_pigmentation_phenotype0.72731343
141MP0003252_abnormal_bile_duct0.72335100
142MP0001958_emphysema0.72171736
143MP0005390_skeleton_phenotype0.71807797
144MP0004197_abnormal_fetal_growth/weight/0.71434472
145MP0003186_abnormal_redox_activity0.71154677
146MP0010234_abnormal_vibrissa_follicle0.70880117
147MP0001881_abnormal_mammary_gland0.70665453
148MP0002080_prenatal_lethality0.69946015
149MP0003279_aneurysm0.69016926
150MP0002085_abnormal_embryonic_tissue0.67512518
151MP0003868_abnormal_feces_composition0.66735517
152MP0003786_premature_aging0.65751134
153MP0000428_abnormal_craniofacial_morphol0.64983725
154MP0005248_abnormal_Harderian_gland0.64482323
155MP0004883_abnormal_blood_vessel0.61890349

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.51781989
2Recurrent abscess formation (HP:0002722)4.01499370
3Chromsome breakage (HP:0040012)3.93930971
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.81324612
5Recurrent bacterial skin infections (HP:0005406)3.71154579
6Autoimmune thrombocytopenia (HP:0001973)3.58132064
7Papillary thyroid carcinoma (HP:0002895)3.54266132
8Recurrent gram-negative bacterial infections (HP:0005420)3.49944264
9Recurrent fungal infections (HP:0002841)3.23582324
10Premature rupture of membranes (HP:0001788)3.20638195
11Orthostatic hypotension (HP:0001278)3.01398461
12Recurrent viral infections (HP:0004429)3.00915024
13Rhabdomyosarcoma (HP:0002859)2.95649958
14Myositis (HP:0100614)2.88744227
15Abnormality of macrophages (HP:0004311)2.84897919
16Abnormality of chromosome stability (HP:0003220)2.84460212
17Mediastinal lymphadenopathy (HP:0100721)2.82654143
18Thyroid carcinoma (HP:0002890)2.79714807
19Abnormality of glycolipid metabolism (HP:0010969)2.76556461
20Abnormality of liposaccharide metabolism (HP:0010968)2.76556461
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.76556461
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.66730730
23Osteolytic defects of the hand bones (HP:0009699)2.66730730
24Thrombocytosis (HP:0001894)2.63110207
25Biliary tract neoplasm (HP:0100574)2.62700800
26Elevated erythrocyte sedimentation rate (HP:0003565)2.61893545
27Myocardial infarction (HP:0001658)2.60441514
28Orchitis (HP:0100796)2.58628072
29Arterial thrombosis (HP:0004420)2.55854220
30Abnormality of methionine metabolism (HP:0010901)2.53839647
31Pustule (HP:0200039)2.53262537
32Abnormality of the fingertips (HP:0001211)2.51080768
33Nasal polyposis (HP:0100582)2.50071897
34Cutaneous melanoma (HP:0012056)2.47131780
35Cellulitis (HP:0100658)2.46505975
36Recurrent skin infections (HP:0001581)2.40955430
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40158349
38Abnormal biliary tract morphology (HP:0012440)2.39772609
39Interstitial pulmonary disease (HP:0006530)2.39615659
40IgM deficiency (HP:0002850)2.39098649
41Vacuolated lymphocytes (HP:0001922)2.38928605
42Hematochezia (HP:0002573)2.35964302
43Retrobulbar optic neuritis (HP:0100654)2.35795494
44Optic neuritis (HP:0100653)2.35795494
45Gingivitis (HP:0000230)2.34890870
46Curly hair (HP:0002212)2.34837852
47* Periodontitis (HP:0000704)2.34690672
48Gingival bleeding (HP:0000225)2.34252050
49Absent frontal sinuses (HP:0002688)2.33404530
50Deep philtrum (HP:0002002)2.32808605
51Entropion (HP:0000621)2.31945149
52Vasculitis (HP:0002633)2.30932437
53Syringomyelia (HP:0003396)2.30072044
54Spinal cord lesions (HP:0100561)2.30072044
55Recurrent bronchitis (HP:0002837)2.29805819
56Nephroblastoma (Wilms tumor) (HP:0002667)2.28583425
57Esophageal varix (HP:0002040)2.26822346
58Abnormality of T cell number (HP:0011839)2.25158348
59Systemic lupus erythematosus (HP:0002725)2.24272602
60Thoracolumbar scoliosis (HP:0002944)2.23415337
61Increased cerebral lipofuscin (HP:0011813)2.23258809
62IgA deficiency (HP:0002720)2.22644159
63Neoplasm of the small intestine (HP:0100833)2.22570756
64Volvulus (HP:0002580)2.20476461
65Asymmetry of the thorax (HP:0001555)2.19063416
66Embryonal renal neoplasm (HP:0011794)2.17264321
67Abnormality of the nasal mucosa (HP:0000433)2.16621844
68Chronic obstructive pulmonary disease (HP:0006510)2.14114120
69Obstructive lung disease (HP:0006536)2.14114120
70Cardiovascular calcification (HP:0011915)2.13715065
71Aortic dissection (HP:0002647)2.12859921
72Abnormality of T cells (HP:0002843)2.12858032
73B lymphocytopenia (HP:0010976)2.11677413
74Abnormality of B cell number (HP:0010975)2.11111935
75T lymphocytopenia (HP:0005403)2.10655268
76Bladder neoplasm (HP:0009725)2.09988207
77Bladder carcinoma (HP:0002862)2.09988207
78Neoplasm of the rectum (HP:0100743)2.09603304
79Abnormality of T cell physiology (HP:0011840)2.08523380
80Petechiae (HP:0000967)2.08321543
81Transitional cell carcinoma of the bladder (HP:0006740)2.07215254
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.06237784
83Amaurosis fugax (HP:0100576)2.05928250
84Ascites (HP:0001541)2.04709530
85Metaphyseal irregularity (HP:0003025)2.04231921
86Abnormal platelet volume (HP:0011876)2.03861455
87Leukocytosis (HP:0001974)2.03585630
88Prostate neoplasm (HP:0100787)2.02703934
89Agnosia (HP:0010524)2.02136669
90Neoplasm of striated muscle (HP:0009728)2.02023198
91Abnormal foot bone ossification (HP:0010675)2.01902138
92Recurrent cutaneous fungal infections (HP:0011370)1.98214535
93Chronic mucocutaneous candidiasis (HP:0002728)1.98214535
94Delayed closure of the anterior fontanelle (HP:0001476)1.96927427
95Soft skin (HP:0000977)1.95859496
96Acute myeloid leukemia (HP:0004808)1.94249599
97Osteomyelitis (HP:0002754)1.93859442
98Cone-rod dystrophy (HP:0000548)1.93854916
99Coarse hair (HP:0002208)1.92315454
100Arterial tortuosity (HP:0005116)1.91658086
101Eosinophilia (HP:0001880)1.91601895
102Gastrointestinal infarctions (HP:0005244)1.91063720
103Inflammation of the large intestine (HP:0002037)1.90685367
104Autoamputation (HP:0001218)1.90337313
105Prolonged bleeding time (HP:0003010)1.90216809
106Cervical subluxation (HP:0003308)1.89552563
107Vertebral compression fractures (HP:0002953)1.89363271
108Increased mean platelet volume (HP:0011877)1.88908704
109Pulmonary infiltrates (HP:0002113)1.88852601
110Gastrointestinal inflammation (HP:0004386)1.88776568
111Anhidrosis (HP:0000970)1.88142068
112Protrusio acetabuli (HP:0003179)1.87901840
113Abnormal platelet function (HP:0011869)1.87828209
114Impaired platelet aggregation (HP:0003540)1.87828209
115Pulmonic stenosis (HP:0001642)1.87455178
116Vascular tortuosity (HP:0004948)1.86875101
117Combined immunodeficiency (HP:0005387)1.86062946
118Anorexia (HP:0002039)1.85715326
119* Fair hair (HP:0002286)1.85680586
120Colitis (HP:0002583)1.84827190
121Subacute progressive viral hepatitis (HP:0006572)1.84713023
122Epistaxis (HP:0000421)1.84427830
123Aortic aneurysm (HP:0004942)1.84171500
124Intrahepatic cholestasis (HP:0001406)1.84029888
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82300005
126Renal cortical cysts (HP:0000803)1.82291734
127Poor head control (HP:0002421)1.81908889
128Granulocytopenia (HP:0001913)1.81744075
129Thin bony cortex (HP:0002753)1.81592682
130Chronic otitis media (HP:0000389)1.80925165
131Breast carcinoma (HP:0003002)1.80314900
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.79864935
133Chest pain (HP:0100749)1.79196600
134Meckel diverticulum (HP:0002245)1.79027648
135Symptomatic seizures (HP:0011145)1.78577066
136Vascular calcification (HP:0004934)1.77835947
137Spondylolisthesis (HP:0003302)1.77407765
138Meningitis (HP:0001287)1.76901747
139Barrel-shaped chest (HP:0001552)1.76226164
140Prominent nose (HP:0000448)1.75763231
141Mucopolysacchariduria (HP:0008155)1.74553909
142Urinary glycosaminoglycan excretion (HP:0003541)1.74553909
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.74517852
144Microglossia (HP:0000171)1.74246534
145High pitched voice (HP:0001620)1.73980369
146Degeneration of anterior horn cells (HP:0002398)1.73715646
147Abnormality of the anterior horn cell (HP:0006802)1.73715646
148Axonal loss (HP:0003447)1.73204363
149Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72202279
150Lower limb hyperreflexia (HP:0002395)1.71996403
151Ovarian neoplasm (HP:0100615)1.70758397
152Chronic diarrhea (HP:0002028)1.70729396
153Cystic hygroma (HP:0000476)1.70012782
154Autoimmune hemolytic anemia (HP:0001890)1.69899948
155Glioma (HP:0009733)1.69624956
156Cerebral aneurysm (HP:0004944)1.68936166
157Abnormality of the ileum (HP:0001549)1.68711848
158Decreased skull ossification (HP:0004331)1.68706321
159Thyroiditis (HP:0100646)1.68618715
160Hypergammaglobulinemia (HP:0010702)1.68497666
161Abnormality of the prostate (HP:0008775)1.68317014
162Follicular hyperkeratosis (HP:0007502)1.68003832
163Natal tooth (HP:0000695)1.67873481
164Hemoptysis (HP:0002105)1.67668715
165Abnormality of the preputium (HP:0100587)1.67615700
166Abnormality of eosinophils (HP:0001879)1.67559145
167Abnormality of the astrocytes (HP:0100707)1.67043504
168Astrocytoma (HP:0009592)1.67043504
169Uterine neoplasm (HP:0010784)1.66536925
170Lymphopenia (HP:0001888)1.66171528
171Abnormality of the pancreatic islet cells (HP:0006476)1.65828834
172Abnormality of endocrine pancreas physiology (HP:0012093)1.65828834
173Disinhibition (HP:0000734)1.65696473
174Ectropion (HP:0000656)1.65330460
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65244010
176Ependymoma (HP:0002888)1.64348493
177Tetraparesis (HP:0002273)1.62770077
178Narrow palate (HP:0000189)1.61284569
179Overlapping toe (HP:0001845)1.61066882
180Myelodysplasia (HP:0002863)1.60448907
181Neoplasm of the colon (HP:0100273)1.58899522
182Stillbirth (HP:0003826)1.58327043
183Ankle contracture (HP:0006466)1.58314333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK22.86445016
2CDK122.79044280
3JAK32.61012918
4LATS12.55461657
5MAP4K12.51783638
6MAP3K142.37348830
7TYK22.27069999
8BLK2.21255897
9STK102.14978059
10TAOK32.14550449
11EIF2AK12.12758251
12PKN22.01434305
13NUAK12.00189852
14BUB11.98192388
15EEF2K1.94520825
16TBK11.91521510
17EIF2AK31.89157317
18TRIM281.87767849
19ZAP701.86001013
20FGFR41.84126333
21TRIB31.83069937
22MAP3K101.82021035
23ERN11.80463225
24NEK11.78382632
25IRAK31.66076203
26PIK3CG1.58266132
27KIT1.56367727
28JAK11.56028703
29NEK91.55535615
30SRPK11.54659278
31FLT31.54496098
32STK31.54108617
33IKBKB1.52213145
34NEK21.51990568
35BMPR21.49731228
36CHUK1.49423619
37TXK1.49103253
38MKNK11.46073134
39PLK31.45955813
40MKNK21.44939659
41ERBB41.43636376
42RPS6KA41.41104080
43LRRK21.40955303
44IRAK41.39459313
45PTK61.38898976
46IKBKE1.38634393
47FGFR31.37015024
48NLK1.34543670
49BMPR1B1.31551873
50CDK61.30447336
51PIM11.30320170
52STK241.28371950
53CSF1R1.27873598
54BTK1.20930525
55CSK1.19615977
56MST1R1.18542275
57PIM21.16803677
58STK41.15795080
59EPHB11.13034029
60SCYL21.09791184
61RIPK41.09671331
62CDC71.09459990
63ERBB31.09265029
64FER1.08719900
65CDK41.07725827
66RIPK11.06654993
67MET1.06148275
68STK38L1.04041865
69HCK0.99097564
70TEC0.97510273
71ZAK0.97157990
72PAK40.96845834
73ITK0.96827581
74SYK0.95065486
75TESK10.93875008
76MAP2K30.93772798
77MAP3K20.92820497
78PDK20.92602932
79EPHA30.92380172
80MOS0.91898441
81TGFBR20.89741938
82LCK0.88361157
83CAMK1G0.88310158
84CLK10.88056931
85MATK0.86637590
86KSR10.86454392
87MAP3K80.85330877
88ATR0.84677975
89PDGFRA0.84666209
90MST40.84502852
91FGFR10.83790759
92MTOR0.81692854
93TTN0.81473269
94JAK20.81462766
95SIK10.80971183
96CDK70.80891868
97NME20.79340598
98STK390.78726160
99PLK10.78266373
100RAF10.78038911
101ICK0.77326943
102EPHA20.76050592
103LYN0.74168372
104CHEK20.73690041
105BMX0.72819299
106ALK0.72296399
107CAMK1D0.70436082
108MARK30.70114131
109RPS6KB20.68605038
110IRAK10.66092515
111MYLK0.65528356
112PBK0.65205847
113TRPM70.64895965
114DYRK30.64371477
115MAP3K130.64180579
116WEE10.62746274
117FRK0.61343350
118PDGFRB0.59745691
119TSSK60.59420970
120TAF10.57850729
121CAMKK20.57594592
122EGFR0.57306568
123TNIK0.56521642
124TGFBR10.56418732
125EIF2AK20.56247305
126PTK20.55635640
127AKT30.54843710
128CDK90.54160883
129TTK0.53247808
130KDR0.53189113
131WNK10.52665843
132FGFR20.52601320
133YES10.52037316
134AURKB0.51870800
135BRD40.51235655
136GRK60.51171701
137CDK80.50236796
138DMPK0.47837387
139MELK0.47631419
140FGR0.47243375
141PASK0.46959408
142GRK70.46652126
143MAP4K20.46223894
144MAPKAPK20.43689391
145DDR20.43293451
146PLK20.42753942
147DYRK1B0.41602310
148BRSK10.41597766
149ATM0.40913438
150PAK20.40461584
151CHEK10.40405984
152ABL10.40191079
153MAPK110.40079927
154MAP3K50.39717154
155ACVR1B0.37703592

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.43296899
2Leishmaniasis_Homo sapiens_hsa051402.38572619
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24848998
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21382131
5Legionellosis_Homo sapiens_hsa051342.06877849
6Antigen processing and presentation_Homo sapiens_hsa046121.99539167
7Measles_Homo sapiens_hsa051621.98014401
8Staphylococcus aureus infection_Homo sapiens_hsa051501.94793737
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87223877
10Osteoclast differentiation_Homo sapiens_hsa043801.82616263
11Sulfur metabolism_Homo sapiens_hsa009201.78518425
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76501109
13Proteasome_Homo sapiens_hsa030501.74972029
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.71726725
15Nucleotide excision repair_Homo sapiens_hsa034201.67206599
16Herpes simplex infection_Homo sapiens_hsa051681.63602538
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61524032
18Influenza A_Homo sapiens_hsa051641.59071970
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58239145
20Basal transcription factors_Homo sapiens_hsa030221.58021411
21Graft-versus-host disease_Homo sapiens_hsa053321.57076654
22Allograft rejection_Homo sapiens_hsa053301.52459995
23Primary immunodeficiency_Homo sapiens_hsa053401.51705997
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51221405
25Toxoplasmosis_Homo sapiens_hsa051451.49142439
26TNF signaling pathway_Homo sapiens_hsa046681.47881676
27Pertussis_Homo sapiens_hsa051331.43235082
28B cell receptor signaling pathway_Homo sapiens_hsa046621.41732849
29Apoptosis_Homo sapiens_hsa042101.37282041
30Shigellosis_Homo sapiens_hsa051311.36113141
31Malaria_Homo sapiens_hsa051441.34092622
32Hepatitis B_Homo sapiens_hsa051611.34028818
33Hematopoietic cell lineage_Homo sapiens_hsa046401.31648093
34Tuberculosis_Homo sapiens_hsa051521.29665704
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.28930717
36Thyroid cancer_Homo sapiens_hsa052161.26852787
37DNA replication_Homo sapiens_hsa030301.25613900
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.25178003
39RNA degradation_Homo sapiens_hsa030181.24805579
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24619776
41TGF-beta signaling pathway_Homo sapiens_hsa043501.23920826
42p53 signaling pathway_Homo sapiens_hsa041151.22189367
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.21773273
44Chronic myeloid leukemia_Homo sapiens_hsa052201.21204868
45Small cell lung cancer_Homo sapiens_hsa052221.20983984
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20455307
47Dorso-ventral axis formation_Homo sapiens_hsa043201.19795224
48Viral myocarditis_Homo sapiens_hsa054161.18541854
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16974187
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.14975395
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13643219
52Viral carcinogenesis_Homo sapiens_hsa052031.11020069
53One carbon pool by folate_Homo sapiens_hsa006701.08356136
54Salmonella infection_Homo sapiens_hsa051321.08212126
55Acute myeloid leukemia_Homo sapiens_hsa052211.03558421
56Sphingolipid metabolism_Homo sapiens_hsa006001.03058707
57N-Glycan biosynthesis_Homo sapiens_hsa005101.02723690
58Cell cycle_Homo sapiens_hsa041101.01894117
59Other glycan degradation_Homo sapiens_hsa005111.00450182
60ECM-receptor interaction_Homo sapiens_hsa045121.00209489
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98865579
62Base excision repair_Homo sapiens_hsa034100.98249666
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97286972
64* Lysosome_Homo sapiens_hsa041420.97241928
65Steroid biosynthesis_Homo sapiens_hsa001000.96663244
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96487178
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96135677
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94424240
69Notch signaling pathway_Homo sapiens_hsa043300.90515425
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90381664
71MicroRNAs in cancer_Homo sapiens_hsa052060.90117218
72Adherens junction_Homo sapiens_hsa045200.90046325
73T cell receptor signaling pathway_Homo sapiens_hsa046600.88689927
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88155798
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87936454
76RNA transport_Homo sapiens_hsa030130.86909643
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86082510
78Asthma_Homo sapiens_hsa053100.85834983
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85765756
80Mismatch repair_Homo sapiens_hsa034300.85395400
81Epstein-Barr virus infection_Homo sapiens_hsa051690.85006164
82Non-homologous end-joining_Homo sapiens_hsa034500.83865691
83Pancreatic cancer_Homo sapiens_hsa052120.83571082
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81874221
85Selenocompound metabolism_Homo sapiens_hsa004500.81794705
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81750773
87Chemokine signaling pathway_Homo sapiens_hsa040620.80264015
88HTLV-I infection_Homo sapiens_hsa051660.79834763
89Hepatitis C_Homo sapiens_hsa051600.74078557
90Glutathione metabolism_Homo sapiens_hsa004800.73951386
91Proteoglycans in cancer_Homo sapiens_hsa052050.72986616
92Bladder cancer_Homo sapiens_hsa052190.70196127
93Amoebiasis_Homo sapiens_hsa051460.70149151
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69910776
95Platelet activation_Homo sapiens_hsa046110.67873144
96Type I diabetes mellitus_Homo sapiens_hsa049400.67326306
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67061459
98Renal cell carcinoma_Homo sapiens_hsa052110.65395212
99Complement and coagulation cascades_Homo sapiens_hsa046100.65085166
100Renin-angiotensin system_Homo sapiens_hsa046140.64168476
101Folate biosynthesis_Homo sapiens_hsa007900.63484346
102Caffeine metabolism_Homo sapiens_hsa002320.63278651
103HIF-1 signaling pathway_Homo sapiens_hsa040660.63256059
104Lysine degradation_Homo sapiens_hsa003100.61002720
105Prolactin signaling pathway_Homo sapiens_hsa049170.60507265
106Homologous recombination_Homo sapiens_hsa034400.60479707
107Pentose phosphate pathway_Homo sapiens_hsa000300.60030140
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.58256674
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58242979
110Pyrimidine metabolism_Homo sapiens_hsa002400.58110962
111Propanoate metabolism_Homo sapiens_hsa006400.57560842
112Insulin resistance_Homo sapiens_hsa049310.57399456
113Melanoma_Homo sapiens_hsa052180.56078582
114Fatty acid elongation_Homo sapiens_hsa000620.55688204
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55442286
116FoxO signaling pathway_Homo sapiens_hsa040680.54875356
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53680822
118Autoimmune thyroid disease_Homo sapiens_hsa053200.53496186
119Non-small cell lung cancer_Homo sapiens_hsa052230.53370217
120Phagosome_Homo sapiens_hsa041450.53124830
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53039486
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52237760
123mTOR signaling pathway_Homo sapiens_hsa041500.52153093
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.52121747
125Focal adhesion_Homo sapiens_hsa045100.51856280
126Rheumatoid arthritis_Homo sapiens_hsa053230.51341575
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.50686977
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.50660434
129Prostate cancer_Homo sapiens_hsa052150.50477216
130African trypanosomiasis_Homo sapiens_hsa051430.49819095
131Systemic lupus erythematosus_Homo sapiens_hsa053220.48598600
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48578970
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47136167
134mRNA surveillance pathway_Homo sapiens_hsa030150.46736287
135Inositol phosphate metabolism_Homo sapiens_hsa005620.46181358
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45253986
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43814657
138Fanconi anemia pathway_Homo sapiens_hsa034600.43619190
139Spliceosome_Homo sapiens_hsa030400.42898718
140Endometrial cancer_Homo sapiens_hsa052130.42658875
141Colorectal cancer_Homo sapiens_hsa052100.41478700
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40279685

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